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Cell No. : Cell Name
RCB0135 : L5178Y  update : 2024/01/17
CommentRapidly growing lymphoma
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Kaneko, Ichiro
Year of deposit 1987
Animal _mouse < Mammals
Tissue lymph node
Disease name lymphoma
Classification other
History RIKEN.-K.Kaneko
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_2097
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Culture method
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
Chromosome mode 32-79(50) : /36(2),37(5),38(10),39(6),40(3),42(5)/
Reference information Reference 13
User's Publication 13

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2617  Applegate, M L, Moore, M M, Broder, C B, Burrell A, Juhn G, Kasweck, K L, Lin, P F, Wadhams A, Hozier, J C  Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells.  Proc Natl Acad Sci U S A  1990  87:51-5  PubMed ID: 1967496   DOI: 10.1073/pnas.87.1.51
2616  Chen, L P, Suzuki Y, Liu, C M, Wheelock, E F  Maintenance and cure of the L5178Y murine tumor-dormant state by interleukin 2: dependence of interleukin 2 on induced interferon-gamma and on tumor necrosis factor for its antitumor effects.  Cancer Res  1990  50:1368-74  PubMed ID: 2105837  
2619  Doerr, C L, Harrington-Brock K, Moore, M M  Micronucleus, chromosome aberration, and small-colony TK mutant analysis to quantitate chromosomal damage in L5178Y mouse lymphoma cells.  Mutat Res  1989  222:191-203  PubMed ID: 2466200   DOI: 10.1016/0165-1218(89)90135-3
2618  Furuno-Fukushi I, Ueno, A M, Matsudaira H  Mutation induction by very low dose rate gamma rays in cultured mouse leukemia cells L5178Y.  Radiat Res  1988  115:273-80  PubMed ID: 3406368  
2624  Hama-Inaba H, Hieda-Shiomi N, Shiomi T, Sato K  Isolation and characterization of mitomycin-C-sensitive mouse lymphoma cell mutants.  Mutat Res  1983  108:405-16  PubMed ID: 6403846   DOI: 10.1016/0027-5107(83)90136-7
2626  Sato K, Hieda-Shiomi N, Hama-Inaba H  X-ray-sensitive mutant mouse cells with various sensitivities to chemical mutagens.  Mutat Res  1983  121:281-5  PubMed ID: 6413855   DOI: 10.1016/0165-7992(83)90215-4
2622  Shiomi T, Hieda-Shiomi N, Sato K  Isolation of UV-sensitive mutants of mouse L5178Y cells by a cell suspension spotting method.  Somatic Cell Genet  1982  8:329-345  PubMed ID: 7112349   DOI: 10.1007/BF01538891
2623  Shiomi T, Hieda-Shiomi N, Sato K  A novel mutant of mouse lymphoma cells sensitive to alkylating agents and caffeine.  Mutat Res  1982  103:61-9  PubMed ID: 7057785   DOI: 10.1016/0165-7992(82)90088-4
2621  Sato K, Hieda N  Isolation of a mammalian cell mutant sensitive to 4-nitroquinoline-1-oxide.  Int J Radiat Biol Relat Stud Phys Chem Med  1979  35:83-7  PubMed ID: 109406   DOI: 10.1080/09553007914550071
2625  Sato K, Hieda N  Isolation and characterization of a mutant mouse lymphoma cell sensitive to methyl methanesulfonate and X rays.  Radiat Res  1979  78:167-71  PubMed ID: 221956  
238  Suzuki N, Okada S  Isolation of nutrient deficient mutants and quantitative mutation assay by reversion of alanine-requiring L5178Y cells.  Mutat Res  1976  34:489-505  PubMed ID: 817197   DOI: 10.1016/0027-5107(76)90225-6
2620  Alexander, P.  Mouse lymphoma cells with different radiosensitivities.  Nature  1961  192:572-573  PubMed ID: 13860357   DOI: 10.1038/192572a0
237  FISCHER, G A, WELCH, A D  Effect of citrovorum factor and peptones on mouse leukemia cells L-5178 in tissue culture.  Science  1957  126:1018-9  PubMed ID: 13486055   DOI: 10.1126/science.126.3281.1018

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User's Publication
11216  Amiri Moghani AR, Sharma MK, Matsumoto Y.  In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK.  J. Radiat. Res.  2018    PubMed ID: 30247612   DOI: 10.1093/jrr/rry072
3032  Wada, Seiichi, Kurahayashi, Hidemitsu, Kobayashi, Yasuhiko, Funayama, Tomoo, Yamamoto, Kazuo, Natsuhori, Masahiro, Ito, Nobuhiko  The relationship between cellular radiosensitivity and radiation-induced DNA damage measured by the comet assay.  J Vet Med Sci  2003  65:471-7  PubMed ID: 12736429   DOI: 10.1292/jvms.65.471
3031  Wada, Seiichi, Khoa, Tran Van, Kobayashi, Yasuhiko, Funayama, Tomoo, Yamamoto, Kazuo, Natsuhori, Masahiro, Ito, Nobuhiko  Detection of radiation-induced apoptosis using the comet assay.  J Vet Med Sci  2003  65:1161-6  PubMed ID: 14665742   DOI: 10.1292/jvms.65.1161
4076  Nonaka M, Ikeda H, Inokuchi T.  Effect of combined photodynamic and chemotherapeutic treatment on lymphoma cells in vitro  Cancer Lett  2002  184(2):171-8  PubMed ID: 12127689   DOI: 10.1016/s0304-3835(02)00208-2
2380  Yokota S, Yanagi H, Yura T, Kubota H  Cytosolic chaperonin is up-regulated during cell growth. Preferential expression and binding to tubulin at G(1)/S transition through early S phase.  J Biol Chem  1999  274:37070-8  PubMed ID: 10601265   DOI: 10.1074/jbc.274.52.37070
4067  TAKAHIRO SUZUKI TORU EZURE MASARU ISHIDA  In‐vitro Antitumour Activity of Extracts From Cyanobacteria  Pharmacy and Pharmacology Communications  1999  5:619-622    DOI: 10.1211/146080899128734244
2359  Suzuki T, Ezure T, Ishida M  Synergistic effects of some pairs of antioxidants and related agents on mouse leukaemia L5178Y cell growth in-vitro  J Pharm Pharmacol  1998  50:1173-1177  PubMed ID: 9821666   DOI: 10.1111/j.2042-7158.1998.tb03330.x
1944  Suzuki, T., and Ishida, M.  Application of Neural Networks in Quantitative Structure-activity Relationships of Cytotoxicity of Antioxidants  Pharmaceutical Sciences  1995  1:297-300   
5411  Nakamura M, Sakanaka C, Aoki Y, Ogasawara H, Tsuji T, Kodama H, Matsumoto T, Shimizu T, Noma M.  Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors.  J Biol Chem  1995  270(50):30102-10  PubMed ID: 8530415   DOI: 10.1074/jbc.270.50.30102
1850  Suzuki Takahiro, Ohtaguchi Kazuhisa and Koide Kozo  Modelling the cytotoxicity of antioxidants to mouse leukaemia L5178Y cells in vitro  Pharmaceutical Science Communications  1994  4:171-181   
1772  Suzuki, T., Ohtaguchi, K. and Koide, K.  Cell Growth Inhibition in Mouse Leukemia L5178Y Cells In Vitro by Crude Extracts from Freshwater Blue-Green Algae  J Chemical Engineering  1993  26:463-464    DOI: 10.1252/jcej.26.463
6251  Hye-Sook Chang , Daiji Endoh, Yushi Ishida, Hiroyuki Takahashi, Shuji Ozawa, Masanobu Hayashi, Akira Yabuki, Osamu Yamato  Radioprotective effect of alk(en)yl thiosulfates derived from allium vegetables against DNA damage caused by X-ray irradiation in cultured cells: antiradiation potential of onions and garlic  ScientificWorldJournal  2012  846750  PubMed ID: 22919357   DOI: 10.1100/2012/846750
5901  Masanobu Kawanishi, Katsuyuki Okuyama, Kazunori Shiraishi, Yatsuka Matsuda, Ryoichi Taniguchi, Nobuyuki Shiomi, Morio Yonezawa, Takashi Yagi  Growth retardation of Paramecium and mouse cells by shielding them from background radiation  J Radiat Res  2012  53(3):404-10  PubMed ID: 22739010   DOI: 10.1269/jrr.11145

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