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細胞番号 : 細胞名
RCB0098 : A549  update : 2024/10/17
細胞特性(Comment:英)Human cell line derived from lung cancer.
細胞特性(日)ヒト肺癌由来細胞株。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Abe, Shin-ichiro
樹立者 Giard, D. J.
寄託日 1986
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
採取組織 lung
病名 adenocarcinoma
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0023
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
アイソザイム検査 LD, NP, G6PD
染色体検査 59-64(50) : 59(3),60(2),61(8),62(21),63(14),64(2)
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 1件
Reference(日) 1件
利用者成果(英) 375件
利用者成果(日) 0件

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Reference(英)
4609  Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G.  A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.  Int J Cancer  1976  17(1):62-70  PubMed ID: 175022   DOI: 10.1002/ijc.2910170110

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Reference(日)
1708  清水信義  ヒト腺癌 : A549  生体の科学  1992  43:395   

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利用者成果(英)
22181  Tomihari M, Iwasaki M, Ishikawa M.  Propranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells.  Biomed Res  2024:253-259  45(6)  PubMed ID: 39581614   DOI: 10.2220/biomedres.45.253
21542  Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A.  RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality.  J Am Chem Soc  2024    PubMed ID: 38170469   DOI: 10.1021/jacs.3c09524
21618  Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T.  PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.  J Biol Chem  2024  300(1):105584  PubMed ID: 38141761   DOI: 10.1016/j.jbc.2023.105584
21652  Yoshida T, Goto K, Kodama A, Bolidong D, Seto T, Hanayama R.  Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity.  Arch Biochem Biophys  2024  755:109964  PubMed ID: 38527699   DOI: 10.1016/j.abb.2024.109964
21806  Suzuki M, Kobayashi H, Hara D, Hanaoka H.  Elimination of radiation-induced senescent cancer cells and stromal cells in vitro by near-infrared photoimmunotherapy.  Cancer Med  2024  13(12):e7381  PubMed ID: 38888415   DOI: 10.1002/cam4.7381
21821  Ito T, Tamashiro S, Okuda H, Yamazoe E, Tahara K.  Cryomilled electrospun nanofiber mats containing d-mannitol exhibit suitable for aerosol delivery of proteins.  Int J Pharm  2024  661:124425  PubMed ID: 38971509   DOI: 10.1016/j.ijpharm.2024.124425
21833  Hata M, Kadoya Y, Ueno J, Taki M, Kodera M.  Dicopper Complexes of p-Cresol-2,6-bis(amide-tether-dpa4-X) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups.  Inorg Chem  2024    PubMed ID: 39011904   DOI: 10.1021/acs.inorgchem.4c01072
21878  Kimura R, Hashimoto S, Eguchi H, Morikawa Y, Suenami K, Yoshino Y, Matsunaga T, Endo S, Ikari A.  Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells.  Arch Biochem Biophys  2024  110106  PubMed ID: 39067558   DOI: 10.1016/j.abb.2024.110106
21889  Nii T, Hijii S, Kaneko R, Tanito K, Yamanaka K, Kishimura A, Mori T, Katayama Y.  In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme.  Anal Sci  2024  40(8):1529-1535  PubMed ID: 38748393   DOI: 10.1007/s44211-024-00593-9
22013  Takahashi K, Tanaka T, Ishihara A, Ohta T.  Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity.  Discov Oncol  2024  15(1):177  PubMed ID: 38769217   DOI: 10.1007/s12672-024-01041-w
22182  Pustimbara A, Umami RW, Prakoso NM, Rozaliyani A, Zaini J, Dwiranti A, Ogura SI, Bowolaksono A.  Hemin Promotes Higher Effectiveness of Aminolevulinic-Photodynamic Therapy (ALA-PDT) in A549 Lung Cancer Cell Line by Interrupting ABCG2 Expression.  Med Sci (Basel)  2024  12(4)  PubMed ID: 39584916   DOI: 10.3390/medsci12040066
17622  Maruyama S, Sakabe N, Ito C, Shimoyama Y, Sato S, Ikeda K.  Effect of Specimen Processing Technique on Cell Detection and Classification by Artificial Intelligence  Am J Clin Pathol  2023  aqac178  PubMed ID: 36933198   DOI: 10.1093/ajcp/aqac178
17769  Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H.  Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone  Viruses  2023  15(4):845  PubMed ID: 37112827   DOI: 10.3390/v15040845
17785  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K.  Relationship between a deep learning model and liquid-based cytological processing techniques  Cytopathology  2023  Apr 13  PubMed ID: 37051774   DOI: 10.1111/cyt.13235
17792  Ryo Doge, Yuki Nishino, Akiko Saito  Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria  BioChem  2023  3:61-77    DOI: 10.3390/biochem3020005
17808  Sato Y, Yoshino H, Sato K, Kashiwakura I, Tsuruga E.  DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines  J Radiat Res  2023  rrad016  PubMed ID: 37023702   DOI: 10.1093/jrr/rrad016
17814  Tamai M, Taba S, Mise T, Yamashita M, Ishikawa H, Shintake T.  Ethanol vapor inhalation treatment inhibits lethal respiratory viral infection with Influenza A  J Infect Dis  2023  jiad089  PubMed ID: 37101418   DOI: 10.1093/infdis/jiad089
17816  Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe  In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters  EJNMMI Research  2023  13  PubMed ID: 37115356   DOI: 10.1186/s13550-023-00988-1
19547  Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Ishibashi S, Kawashima-Sonoyama Y, Matsuzaki Y, Taketani T.  Extracellular Vesicles and Cx43-Gap Junction Channels Are the Main Routes for Mitochondrial Transfer from Ultra-Purified Mesenchymal Stem Cells, RECs  Int J Mol Sci  2023  24(12):10294  PubMed ID: 37373439   DOI: 10.3390/ijms241210294
19548  Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A.  CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade  Nat Commun  2023  14(1):7490  PubMed ID: 37980406   DOI: 10.1038/s41467-023-43274-3
19549  Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K.  2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses  Proc Natl Acad Sci U S A  2023  120(42):e2304139120  PubMed ID: 37831739   DOI: 10.1073/pnas.2304139120
19550  Oka N, Shimada K, Ishii A, Kobayashi N, Kondo K.  SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production  iScience  2023  26(6):106954  PubMed ID: 37275532   DOI: 10.1016/j.isci.2023.106954
19554  Amma C, Inomata Y, Kohno R, Satake M, Furukawa A, Nagata Y, Sugiyama H, Seto T, Suzuki R.  Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells  Environ Geochem Health  2023  45(8):5879-5891  PubMed ID: 37179508   DOI: 10.1007/s10653-023-01599-4
19555  Kobayashi A, Hiroyama Y, Mamiya T, Oikawa M, Konishi T.  The COX-2/PGE2 Response Pathway Upregulates Radioresistance in A549 Human Lung Cancer Cells through Radiation-Induced Bystander Signaling  Biology (Basel)  2023  12(11):1368  PubMed ID: 37997966   DOI: 10.3390/biology12111368
19605  Zhang D, Shimokawa T, Guo Q, Dan S, Miki Y, Sunada S.  Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break  Cancer Sci  2023  114(3):1108-1117.  PubMed ID: 36385507   DOI: 10.1111/cas.15659
19918  Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I.  Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation  Toxicol Mech Methods  2023  33(9):741-754  PubMed ID: 37496379   DOI: 10.1080/15376516.2023.2238061
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
19976  Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK.  Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer  J Med Chem  2023  Dec 17  PubMed ID: 38105611   DOI: 10.1021/acs.jmedchem.3c01493
21065  Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A.  Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.  J Am Chem Soc  2023  145(1):135-142  PubMed ID: 36538570   DOI: 10.1021/jacs.2c08974
21080  Miura K, Koyanagi-Aoi M, Maniwa Y, Aoi T.  Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis.  Cancer Cell Int  2023  23(1):34  PubMed ID: 36841751   DOI: 10.1186/s12935-023-02870-5
21168  Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T.  Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer.  Stem Cell Res Ther  2023  14(1):40  PubMed ID: 36927781   DOI: 10.1186/s13287-023-03274-y
21185  Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S.  Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.  Drug Deliv  2023  30(1):2191891  PubMed ID: 36964673   DOI: 10.1080/10717544.2023.2191891
21259  Takata J, Kiura K, Nakasuka T, Hirabae A, Arimoto-Kobayashi S.  Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice.  Genes Environ  2023  45(1):19  PubMed ID: 37280663   DOI: 10.1186/s41021-023-00276-3
21379  Hata M, Ueno J, Hitomi Y, Kodera M.  Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.  ACS Omega  2023  8(31):28690-28701  PubMed ID: 37576680   DOI: 10.1021/acsomega.3c03387
21380  Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I.  Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia.  Anticancer Res  2023  43(8):3429-3439  PubMed ID: 37500171   DOI: 10.21873/anticanres.16518
21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3
21516  Wang H, Zhang H, Tamura R, Da B, Abdellatef SA, Watanabe I, Ishida N, Fujita D, Hanagata N, Nakagawa T, Nakanishi J.  Mapping stress inside living cells by atomic force microscopy in response to environmental stimuli.  Sci Technol Adv Mater  2023  24(1):2265434  PubMed ID: 37867575   DOI: 10.1080/14686996.2023.2265434
21526  Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H.  Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells.  Eur J Pharmacol  2023  960:176156  PubMed ID: 38059445   DOI: 10.1016/j.ejphar.2023.176156
21547  Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T.  Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions.  Biology (Basel)  2023  12(12)  PubMed ID: 38132311   DOI: 10.3390/biology12121485
17494  Maeda A, Fujimura T, Hirakawa N, Baba K, Kawamoto S.  A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells  Biol Pharm Bull  2022  45(10):1581-1584  PubMed ID: 35979561   DOI: 10.1248/bpb.b22-00310
17595  Maki M, JeongMin H, Nakagawa T, Kawai H, Sakamoto N, Sato Y, Noguchi M.  Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome  Pathol Int  2022  72(10):496-505  PubMed ID: 35920378   DOI: 10.1111/pin.13262
17647  Tamari S, Menju T, Toyazaki T, Miyamoto H, Chiba N, Noguchi M, Ishikawa H, Miyata R, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Ohsumi A, Hamaji M, Date H.  Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer  Oncol Rep  2022  48(4):171  PubMed ID: 35959810   DOI: 10.3892/or.2022.8386
18224  Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S.  Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53  Chem Res Toxicol  2022  35(9):1598-1603  PubMed ID: 36027604   DOI: 10.1021/acs.chemrestox.2c00202
13435  Funato N, Yanagisawa H.  TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties  Sci Rep  2022  12(1):20188  PubMed ID: 36418889   DOI: 10.1038/s41598-022-24604-9
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2022  e1485  PubMed ID: 34173723   DOI: 10.1002/cnr2.1485
20391  Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H.  Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs.  J Biosci Bioeng  2022    PubMed ID: 34789413   DOI: 10.1016/j.jbiosc.2021.10.001
20408  Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K.  Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology.  Acta Cytol  2022  1-6  PubMed ID: 34644702   DOI: 10.1159/000519335
20410  Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.  Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.  Radiat Res  2022    PubMed ID: 34634126   DOI: 10.1667/RADE-21-00112.1
20486  Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y.  Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.  Oncol Rep  2022  47(2)  PubMed ID: 34935060   DOI: 10.3892/or.2021.8243
16353  Tsujiya Y, Hasegawa A, Yamamori M, Okamura N.  Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines  Biol Pharm Bull  2022  45(3):276-283  PubMed ID: 35228393   DOI: 10.1248/bpb.b21-00785
20590  Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T.  High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells.  Molecules  2022  27(4)  PubMed ID: 35209077   DOI: 10.3390/molecules27041287
20595  Matsushige T, Sakabe T, Umekita Y.  Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line.  Yonago Acta Med  2022  65(1):44-52  PubMed ID: 35221759   DOI: 10.33160/yam.2022.02.006
20613  Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.  Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.  Analyst  2022    PubMed ID: 35297918   DOI: 10.1039/d2an00052k
20657  Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y.  Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.  Biochem Biophys Rep  2022  29:101223  PubMed ID: 35146136   DOI: 10.1016/j.bbrep.2022.101223
20674  Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y.  The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets.  Cell Rep  2022  39(4):110721  PubMed ID: 35476996   DOI: 10.1016/j.celrep.2022.110721
20684  Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O.  Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis.  Transl Oncol  2022  21:101431  PubMed ID: 35452996   DOI: 10.1016/j.tranon.2022.101431
16485  Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M.  Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration  Int J Mol Sci  2022  23(9):5047  PubMed ID: 35563439   DOI: 10.3390/ijms23095047
16496  Siswanto FM, Tamura A, Sakuma R, Imaoka S.  Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway  Mol Pharmacol  2022  101(4):257-273  PubMed ID: 35193967   DOI: 10.1124/molpharm.121.000475
16710  Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka  A vitamin D C/D ring-derived compound with cytotoxicity  Medicinal Chemistry Research  2022  1120-1125    DOI: 10.1007/s00044-021-02842-2
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20808  Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka  A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity  Chemical and Pharmaceutical Bulletin  2022  477-482  PubMed ID: 35786566   DOI: 10.1248/cpb.c21-01087
16959  Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita  Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells  Medicinal Chemistry Research  2022  31:1584-1593    DOI: 10.1007/s00044-022-02939-2
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20896  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K.  Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network.  Acta Cytol  2022  1-9  PubMed ID: 36067744   DOI: 10.1159/000526098
20912  Kotani N, Nakano T, Kuwahara R.  Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis.  J Biol Chem  2022  298(11):102500  PubMed ID: 36152751   DOI: 10.1016/j.jbc.2022.102500
20963  Takata J, Miyake N, Saiki Y, Tada M, Sasaki K, Kubo T, Kiura K, Arimoto-Kobayashi S.  Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse.  Genes Environ  2022  44(1):26  PubMed ID: 36494703   DOI: 10.1186/s41021-022-00255-0
12851  Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M.  Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M  Bioorg Chem  2021  107:104627  PubMed ID: 33476868   DOI: 10.1016/j.bioorg.2021.104627
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667   DOI: 10.3892/or.2020.7839
13432  Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T.  BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities  Nat Commun  2021  12(1):6767  PubMed ID: 34799586   DOI: 10.1038/s41467-021-27080-3
20016  Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T.  Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.  Sci Rep  2021  11(1):1492  PubMed ID: 33452347   DOI: 10.1038/s41598-021-81077-y
20076  Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K.  Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines.  Biochem Biophys Rep  2021  26:100946  PubMed ID: 33644423   DOI: 10.1016/j.bbrep.2021.100946
13718  Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H.  miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells  Mol Biol Rep  2021  Mar 6  PubMed ID: 33675467   DOI: 10.1007/s11033-021-06255-7
13912  Yamamoto S, Nakanishi J.  Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle  Anal Sci  2021  37(5):741-745  PubMed ID: 33390415   DOI: 10.2116/analsci.20SCP16
20145  Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R.  Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.  J Nat Med  2021    PubMed ID: 33928494   DOI: 10.1007/s11418-021-01519-9
20147  Kariya Y, Oyama M, Suzuki T, Kariya Y.  αvβ3 Integrin induces partial EMT independent of TGF-β signaling.  Commun Biol  2021  4(1):490  PubMed ID: 33883697   DOI: 10.1038/s42003-021-02003-6
14339  Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S.  GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection  mBio  2021  e0326920  PubMed ID: 34061598   DOI: 10.1128/mBio.03269-20
20205  Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K.  Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.  Food Chem Toxicol  2021  154:112319  PubMed ID: 34087405   DOI: 10.1016/j.fct.2021.112319
20278  Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A.  Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.  Eur J Med Chem  2021  215:113288  PubMed ID: 33640763   DOI: 10.1016/j.ejmech.2021.113288
15273  Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T.  Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse  Prostaglandins Other Lipid Mediat  2021  Jul 9  PubMed ID: 34252545   DOI: 10.1016/j.prostaglandins.2021.106580
15490  Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.  LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence  Transl Oncol  2021  14(11):101212  PubMed ID: 34461558   DOI: 10.1016/j.tranon.2021.101212
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20362  Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H.  Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells.  Biochem Biophys Res Commun  2021  577:146-151  PubMed ID: 34517212   DOI: 10.1016/j.bbrc.2021.09.015
20363  Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C.  Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin.  Anticancer Res  2021  41(9):4321-4331  PubMed ID: 34475052   DOI: 10.21873/anticanres.15237
20367  Kariya Y, Oyama M, Kariya Y, Hashimoto Y.  Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.  Biomolecules  2021  11(9)  PubMed ID: 34572536   DOI: 10.3390/biom11091323
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032   DOI: 10.1016/j.heliyon.2021.e08318
20423  Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T.  Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells.  Histochem Cell Biol  2021  155(6):637-653  PubMed ID: 33974136   DOI: 10.1007/s00418-021-01966-1
15879  Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.  5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2  iScience  2021  24(10):103120  PubMed ID: 34541466   DOI: 10.1016/j.isci.2021.103120
15881  Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS.  SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis  Nat Commun  2021  12(1):6602  PubMed ID: 34782627   DOI: 10.1038/s41467-021-26910-8
20510  Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N.  Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device.  Toxics  2021  9(12)  PubMed ID: 34941765   DOI: 10.3390/toxics9120331
16119  Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y.  Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation  Pathol Int  2021  71(1):15-23  PubMed ID: 33112501   DOI: 10.1111/pin.13040
16128  Sato Y, Yoshino H, Kashiwakura I, Tsuruga E.  DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells  Int J Mol Sci  2021  22(1):420  PubMed ID: 33401559   DOI: 10.3390/ijms22010420
16219  Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto  Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma  Cancer Sci  2021  112(12):5114-5126  PubMed ID: 34628698   DOI: 10.1111/cas.15160
16225  M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki  Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells  Folia Biol (Praha)  2021  67(2):62-69.  PubMed ID: 34624938  
16231  Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A.  Upregulation of Chemoresistance by Mg 2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells  Cells  2021  10(5):1179  PubMed ID: 34066059   DOI: 10.3390/cells10051179
16523  Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami  Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis  Particle & Particle Systems Characterization  2021  38:2100003    DOI: 10.1002/ppsc.202100003
17827  Hirofumi Kurita, Yoshie Minamijima, Kazunori Takashima  Characterization of intracellular reactive species production stimulated by cold atmospheric pressure plasma irradiation  Int. J. Plasma Environ. Sci. Technol  2020  14:e03003 (9pp)    DOI: 10.34343/ijpest.2020.14.e03003
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9729  Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto  Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts  Exp Cell Res  2020  391(2):112010  PubMed ID: 32305327   DOI: 10.1016/j.yexcr.2020.112010
9819  Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto  Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis  Biosci Biotechnol Biochem  2020  84(4):757-763  PubMed ID: 31868102   DOI: 10.1080/09168451.2019.1706442
11986  Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K.  Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.  J. Radiat. Res.  2020  61(2):237-242.  PubMed ID: 31904079   DOI: 10.1093/jrr/rrz098
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12375  Morita S, Horii T, Kimura M, Hatada I.  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform  Int J Mol Sci   2020  21(5):1574  PubMed ID: 32106616   DOI: 10.3390/ijms21051574
12376  Uddin M, Kawami M, Yumoto R, Takano M.  Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells  Naunyn Schmiedebergs Arch Pharmacol  2020  393(5):889-896  PubMed ID: 31900520   DOI: 10.1007/s00210-019-01802-3
12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206   DOI: 10.3727/096504019X15736439848765
12989  Endo M, Ohba K, Sato S, Yokota Y, Takahashi K.  Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells.  Genes Cells  2020    PubMed ID: 32314441   DOI: 10.1111/gtc.12776
12990  Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A.  Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression.  Nutrients  2020    PubMed ID: 32340376   DOI: 10.3390/nu12041190
12998  Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H.  Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.  Appl Radiat Isot  2020    PubMed ID: 32561042   DOI: 10.1016/j.apradiso.2020.109201
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13021  Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K.  Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation.  PLoS One  2020    PubMed ID: 32374749   DOI: 10.1371/journal.pone.0232724
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13167  Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N.  Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy.  Biochem Biophys Res Commun  2020    PubMed ID: 32828300   DOI: 10.1016/j.bbrc.2020.07.082
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095   DOI: 10.1080/03639045.2020.1825473
13260  Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y.  Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.  Immun Inflamm Dis  2020    PubMed ID: 33016012   DOI: 10.1002/iid3.355
13295  Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y.  Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells.  Oncol Lett  2020    PubMed ID: 33133262   DOI: 10.3892/ol.2020.12226
13342  Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N.  Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity.  Nanomaterials (Basel)  2020    PubMed ID: 33202926   DOI: 10.3390/nano10112250
13523  Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori  Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549  bioRxiv  2020  October 04    DOI: 10.1101/2020.10.02.323881
13535  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  DNA Repair (Amst)  2020  91-92:102872  PubMed ID: 32502756   DOI: 10.1016/j.dnarep.2020.102872
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13622  Sato Y, Yoshino H, Tsuruga E, Kashiwakura I.  Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation  Curr Cancer Drug Targets  2020  20(5):372-381  PubMed ID: 31951181   DOI: 10.2174/1568009620666200115161717
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14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240   DOI: 10.1016/j.chembiol.2020.04.007
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10357  Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci  Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors  Eur J Med Chem  2019  82:111648  PubMed ID: 31493743   DOI: 10.1016/j.ejmech.2019.111648
12378  Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.  CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development  Oncogene  2019  38(14):2580-2594  PubMed ID: 30531840   DOI: 10.1038/s41388-018-0603-7
12379  Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M.  Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis  Clin Cancer Res  2019  25(9):2809-2820  PubMed ID: 30728155   DOI: 10.1158/1078-0432.CCR-18-3631
12380  Chinnathambi S, Hanagata N.  Photostability of quantum dot micelles under ultraviolet irradiation  Luminescence  2019  34(5):472-479  PubMed ID: 30809921   DOI: 10.1002/bio.3618
12381  Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI.  Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake  Photodiagnosis Photodyn Ther  2019  27:327-335  PubMed ID: 31252141   DOI: 10.1016/j.pdpdt.2019.06.017
12382  Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F.  Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma  Cancer Sci  2019  110(2):726-733  PubMed ID: 30499156   DOI: 10.1111/cas.13895
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323   DOI: 10.1186/s12885-017-3958-1
10803  Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M.  Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions.  Lab Chip  2018  18:1378-1387  PubMed ID: 29658964   DOI: 10.1039/c7lc01280b
10805  Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H.  Effects of cationic liposomes with stearylamine against virus infection.  Int J Pharm  2018  543:311-317  PubMed ID: 29625169   DOI: 10.1016/j.ijpharm.2018.04.001
11049  Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H  The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection.  J Infect Dis  2018  217(11):1740-1749  PubMed ID: 29529215   DOI: 10.1093/infdis/jiy081
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296   DOI: 10.1021/acs.bioconjchem.8b00250
11177  Kobayashi A, Konishi T.  Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells.  J. Radiat. Res.  2018  59(6):754-759  PubMed ID: 30124879   DOI: 10.1093/jrr/rry065
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880   DOI: 10.2116/analsci.17P462
4072  Takayuki Hirono et al  MiR-301a/b function as oncomiRs in non-small-cell lung cancer  Integr Mol Med  2018  5: 1-6    DOI: 10.15761/IMM.1000347
4097  Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H.  Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay.  Virus Res  2018  243:69-74  PubMed ID: 29074234   DOI: 10.1016/j.virusres.2017.10.015
4132  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.  Cytotechnology  2018    PubMed ID: 28756527   DOI: 10.1007/s10616-017-0124-1
4133  Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K.  Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis.  Lung  2018    PubMed ID: 29926178   DOI: 10.1007/s00408-018-0134-6
4134  Sato Y, Yoshino H, Kazama Y, Kashiwakura I.  Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer.  Mol Med Rep  2018    PubMed ID: 30320341   DOI: 10.3892/mmr.2018.9536
4135  Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y.  CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30448176   DOI: 10.1016/j.bbrc.2018.11.055
4136  Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.  Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.  Tohoku J. Exp. Med.  2018    PubMed ID: 29459573   DOI: 10.1620/tjem.244.133
4137  Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H.  In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.  Int. J. Biol. Macromol.  2018    PubMed ID: 28964842   DOI: 10.1016/j.ijbiomac.2017.09.085
4138  Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O.  Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30446226   DOI: 10.1016/j.bbrc.2018.11.035
4139  Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M.  High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma.  Pathol. Int.  2018    PubMed ID: 30320419   DOI: 10.1111/pin.12724
4141  Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C.  Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.  Oncotarget  2018    PubMed ID: 30220973   DOI: 10.18632/oncotarget.25994
4468  Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y.  A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells.  Medchemcomm  2018  9(5):783-788  PubMed ID: 30108967   DOI: 10.1039/c8md00010g
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516   DOI: 10.18632/oncotarget.13761
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165   DOI: 10.1002/cbdv.201700105
10280  Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A.  AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier.  Oncol. Rep.  2017  37:3261-3269  PubMed ID: 28440492   DOI: 10.3892/or.2017.5594
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138   DOI: 10.1016/j.mrfmmm.2017.06.006
10924    Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin  RSC Adv  2017  7, 2392-2402    DOI: 10.1039/C6RA26592H
4526  Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata  Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells  Mutation Research/Genetic Toxicology and Environmental Mutagenesis  2017  818, 7-16  PubMed ID: 28477879   DOI: 10.1016/j.mrgentox.2017.04.002
9171  Haruhiko Fuwa, Mizuho Sato  A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells  Mar Drugs  2017  15 (10)  PubMed ID: 29053565   DOI: 10.3390/md15100320
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625   DOI: 10.3892/ijo.2017.3859
12213  Cancer Lett  Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells    2017  390:160-167  PubMed ID: 28093283   DOI: 10.1016/j.canlet.2017.01.006
12218  Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada  Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis  J Pharmacol Toxicol Methods  2017  86:19-27.  PubMed ID: 28259823   DOI: 10.1016/j.vascn.2017.02.023
14030  El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M.  Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2  Biomed Pharmacother  2017  85:549-555  PubMed ID: 27889230   DOI: 10.1016/j.biopha.2016.11.063
14081  Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H.  IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models  Allergy  2017  72(7):1043-1053.   PubMed ID: 27878831   DOI: 10.1111/all.13079
14432  Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M.  miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma  Cancer Sci  2017  108(3):536-542  PubMed ID: 28012229   DOI: 10.1111/cas.13148
14529  Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R.  Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells  Radiat Res  2017  188(5):591-594  PubMed ID: 28829673   DOI: 10.1667/RR14824.1
14665  Takahashi K, Ohta T.  Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells  Biochem Biophys Res Commun  2017  490(3):587-593  PubMed ID: 28629997   DOI: 10.1016/j.bbrc.2017.06.082
14674  Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y.  Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy  J Am Chem Soc  2017  139(39):13713-13719  PubMed ID: 28872304   DOI: 10.1021/jacs.7b05019
14730  Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T.  Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells  Sci Rep  2017  7(1):12317.  PubMed ID: 28951614   DOI: 10.1038/s41598-017-12017-y
16608  Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C.  Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents  Anticancer Res  2017  37(11):6177-6188  PubMed ID: 29061799   DOI: 10.21873/anticanres.12067
7063  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.  Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.  Nat. Biotechnol.  2016  34:1060-1065  PubMed ID: 27571369   DOI: 10.1038/nbt.3658
7193  Yamazoe H, Hagihara Y, Kobayashi H.  Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs.  Tissue Eng Part C Methods  2016  22:20-9  PubMed ID: 26421875   DOI: 10.1089/ten.TEC.2015.0188
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807   DOI: 10.1016/j.bbamcr.2016.02.015
9774  Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H.  Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.  Virus Res.  2016  223:170-80  PubMed ID: 27485920   DOI: 10.1016/j.virusres.2016.07.011
9884  Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C.  Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.  Anticancer Res.  2016  36:6083-6092  PubMed ID: 27793936   DOI: 10.21873/anticanres.11198
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591   DOI: 10.1371/journal.pone.0147957
10117  Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka  Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy  Biomater Sci .   2016  4(5):826-38  PubMed ID: 26971562   DOI: 10.1039/c6bm00011h
12614  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage  J Biochem  2016  159(2):225-37  PubMed ID: 26378248   DOI: 10.1093/jb/mvv098
12629  Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine  Anticancer Res  2016  36(12):6311-6318  PubMed ID: 27919951   DOI: 10.21873/anticanres.11227
12630  Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.  The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo  Oncotarget  2016  7(19):27021-32  PubMed ID: 27027242   DOI: 10.18632/oncotarget.8395
12631  Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J.  Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer  Transl Oncol  2016  9(3):203-10  PubMed ID: 27267838   DOI: 10.1016/j.tranon.2016.03.007
12646  Husni RE, Shiba-Ishii A, Iiyama S, Shiozawa T, Kim Y, Nakagawa T, Sato T, Kano J, Minami Y, Noguchi M.  DNMT3a expression pattern and its prognostic value in lung adenocarcinoma  Lung Cancer  2016  97:59-65  PubMed ID: 27237029   DOI: 10.1016/j.lungcan.2016.04.018
12681  Toyama K, Mizuguchi T, Nomura W, Tamamura H.  Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization  Bioorg Med Chem  2016  24(16):3406-12  PubMed ID: 27283787   DOI: 10.1016/j.bmc.2016.05.026
12948  Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K.  Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2  Cancer Sci  2016  107(9):1321-8  PubMed ID: 27324116   DOI: 10.1111/cas.12995
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853   DOI: 10.1186/s12885-016-2585-6
12974  Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M.  Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation  Part Fibre Toxicol  2016  13:16  PubMed ID: 27026438   DOI: 10.1186/s12989-016-0127-7
13469  Tanabe K.  Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization  Sci Rep  2016  6:25095  PubMed ID: 27117592   DOI: 10.1038/srep25095
13976  Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R.  Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair  Cancer Sci  2016  107(9):1250-5  PubMed ID: 27341700   DOI: 10.1111/cas.12998
13996  Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M.  Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers  Bioconjug Chem  2016  27(10):2307-2314  PubMed ID: 27580353   DOI: 10.1021/acs.bioconjchem.6b00255
14026  Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance  Anticancer Res  2016  36(10):5153-5161  PubMed ID: 27798875   DOI: 10.21873/anticanres.11085
14028  Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.  A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam  PLoS One  2016  11(11):e0166848  PubMed ID: 27875573   DOI: 10.1371/journal.pone.0166848
14041  Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T.  Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark  Chem Biodivers  2016  13(11):1601-1609  PubMed ID: 27492128   DOI: 10.1002/cbdv.201600247
14095  Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida  Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells  Nanoscience and Nanotechnology Letters  2016  8:310-315    DOI: 10.1166/nnl.2016.2132
17169  Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y.  Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)  J Nat Med  2016  70(2):241-52  PubMed ID: 26825781   DOI: 10.1007/s11418-016-0967-3
5653  Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H.  Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.  Anticancer Res  2015  35(8):4411-7  PubMed ID: 26168480  
14286  Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N.  Prognostic significance of MYH9 expression in resected non-small cell lung cancer  PLoS One  2015  10(3):e0121460  PubMed ID: 25826333   DOI: 10.1371/journal.pone.0121460
14460  Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I.  Effects of X‑ray irradiation in combination with ascorbic acid on tumor control  Mol Med Rep  2015  12(4):5449-54  PubMed ID: 26238154   DOI: 10.3892/mmr.2015.4108
14953  Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y.  A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents  Anticancer Res  2015  35(11):5851-5  PubMed ID: 26504007  
15015  Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E.  Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells  Yonago Acta Med  2015  58(1):31-8  PubMed ID: 26190895  
15069  Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T.  Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels  Chem Biodivers  2015  12(4):547-58  PubMed ID: 25879500   DOI: 10.1002/cbdv.201400424
15117  Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A.  Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer  Mol Cancer Ther  2015  14(11):2433-40  PubMed ID: 26351321   DOI: 10.1158/1535-7163.MCT-15-0050
15198  Pauli G, Aepfelbacher M, Bauerfeind U, Blümel J, Burger R, Gärtner B, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Strobel J, Willkommen H, Baylis SA, German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’.  Hepatitis E Virus  Transfus Med Hemother  2015  2(4):247-65.  PubMed ID: 26557817   DOI: 10.1159/000431191
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19157  Ono K, Fujiwara T, Saito K, Nishizawa H, Takahashi N, Suzuki C, Ochi T, Kato H, Ishii Y, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Yamada R, Nakamura Y, Igarashi K, Harigae H.  Cytotoxic and melanogenesis-inhibitory activities of limonoids from the leaves of Azadirachta indica (Neem)  Chem Biodivers  2014  11(3):451-68  PubMed ID: 24634075   DOI: 10.1002/cbdv.201300348
19328  Ono H, Motoi N, Nagano H, Miyauchi E, Ushijima M, Matsuura M, Okumura S, Nishio M, Hirose T, Inase N, Ishikawa Y.  Long noncoding RNA HOTAIR is relevant to cellular proliferation, invasiveness, and clinical relapse in small-cell lung cancer  Cancer Med  2014  3(3):632-42  PubMed ID: 24591352   DOI: 10.1002/cam4.220
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10200  Masanori Horie, Keiko Nishio, Haruhisa Kato, Shigehisa Endoh, Katsuhide Fujita, Ayako Nakamura, Shinichi Kinugasa, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi   Evaluation of Cellular Influences Caused by Calcium Carbonate Nanoparticles  Chem Biol Interact .  2014  210:64-76  PubMed ID: 24412303   DOI: 10.1016/j.cbi.2013.12.013
10254  Toshiko Suzuki-Yamamoto, Sayuri Tanaka, Izumi Tsukayama, Miki Takafuji, Takae Hanada, Toshiya Arakawa, Yuki Kawakami, Masumi Kimoto, Yoshitaka Takahashi  Dioscorea Japonica Extract Down-Regulates Prostaglandin E2 Synthetic Pathway and Induces Apoptosis in Lung Cancer Cells  J Clin Biochem Nutr  2014  55(3):162-7  PubMed ID: 25411520   DOI: 10.3164/jcbn.14-25
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8523  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.  Int J Pharm  2009  382:198-204  PubMed ID: 19646519   DOI: 10.1016/j.ijpharm.2009.07.023
8596  Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y.  The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus.  Pediatr. Res.  2009  66:168-73  PubMed ID: 19390482   DOI: 10.1203/PDR.0b013e3181aa3b2e
8626  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.  Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.  Cancer  2009  115:2580-93  PubMed ID: 19309748   DOI: 10.1002/cncr.24281
8659  Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M.  Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.  Respir. Res.  2009  10:8  PubMed ID: 19192276   DOI: 10.1186/1465-9921-10-8
8688  Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa  Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells  Journal of Health Science  2009  55:845-850    DOI: 10.1248/jhs.55.845
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655   DOI: 10.3945/jn.108.092528
18451  Hannachi Imen E, Nakamura M, Mie M, Kobatake E.  Construction of multifunctional proteins for tissue engineering: epidermal growth factor with collagen binding and cell adhesive activities  J Biotechnol  2009  139(1):19-25  PubMed ID: 18984018   DOI: 10.1016/j.jbiotec.2008.09.011
19002  Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nakano H, Nanashima N, Niki E, Yoshida Y.  Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells  Chem Res Toxicol  2009  22(3):543-53  PubMed ID: 19216582   DOI: 10.1021/tx800289z
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
16646  Matsunami K, Otsuka H, Kondo K, Shinzato T, Kawahata M, Yamaguchi K, Takeda Y.  Absolute configuration of (+)-pinoresinol 4-O-[6''-O-galloyl]-beta-D-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius  Phytochemistry  2009  70(10):1277-85  PubMed ID: 19683319   DOI: 10.1016/j.phytochem.2009.07.020
18311  Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A.  Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter  J Nucl Med  2008  49(4):615-22  PubMed ID: 18344442   DOI: 10.2967/jnumed.107.048231
18334  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T.  Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release  Biosci Biotechnol Biochem  2008  72(9):2481-4  PubMed ID: 18776661   DOI: 10.1271/bbb.80362
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16645  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship  Bioorg Med Chem  2008  16(10):5434-40  PubMed ID: 18440233   DOI: 10.1016/j.bmc.2008.04.016
17238  Matsuda Y, Yamamoto T, Kudo M, Kawahara K, Kawamoto M, Nakajima Y, Koizumi K, Nakazawa N, Ishiwata T, Naito Z.  Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma  Int J Oncol  2008  33(6):1177-85  PubMed ID: 19020750  
18608  Chen H, Zhang L, Jin Z, Jin E, Fujiwara M, Ghazizadeh M, Asoh S, Ohta S, Kawanami O.  Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats  Exp Mol Pathol  2007  83(3):377-84  PubMed ID: 17959170   DOI: 10.1016/j.yexmp.2007.08.016
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16537  Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK.  E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers  Clin Cancer Res  2007  13(10):3043-50  PubMed ID: 17505007   DOI: 10.1158/1078-0432.CCR-06-2103
19312  Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H.  Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest  Nucleic Acids Res  2006  34(17):4878-92.  PubMed ID: 16973895   DOI: 10.1093/nar/gkl651
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158
6458  Misumi T, Tanaka T, Mikawa K, Nishina K, Morikawa O, Obara H.  Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.  J Anesth  2006  20(3):159-65  PubMed ID: 16897233   DOI: 10.1007/s00540-006-0391-z
9054  Naoko Asaoka, Yasuko Tanaka, Tatsuya Sakai, Yutaka Fujii, Reiko Ohuchi, Masanobu Ohuchi  Low Growth Ability of Recent Influenza Clinical Isolates in MDCK Cells Is Due to Their Low Receptor Binding Affinities  Microbes Infect  2006  8 (2), 511-9  PubMed ID: 16300986   DOI: 10.1016/j.micinf.2005.08.006
14324  Gene expression profile changes correlating with radioresistance in human cell lines  Gene expression profile changes correlating with radioresistance in human cell lines  Int J Radiat Oncol Biol Phys  2006  65(1):234-4  PubMed ID: 16618578   DOI: 10.1016/j.ijrobp.2005.12.048
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3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294   DOI: 10.1093/jb/mvi177
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879   DOI: 10.1093/jb/mvi003
3412  Okajima, Shuhei, Yamaguchi, Takeo, Sakai, Yasuyuki, Nakao, Shin-ichi  Regulation of cell adhesion using a signal-responsive membrane substrate.  Biotechnol Bioeng  2005  91:237-43  PubMed ID: 15892056   DOI: 10.1002/bit.20512
3409  Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.  Genes Chromosomes Cancer  2005  44:405-14  PubMed ID: 16114034   DOI: 10.1002/gcc.20253
3021  Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T.  Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.  FEBS Lett  2005  579(17):3829-36  PubMed ID: 15978581   DOI: 10.1016/j.febslet.2005.06.004
3022  Yano Y, Satoh H, Fukumoto K, Kumadaki I, Ichikawa T, Yamada K, Hagiwara K, Yano T.  Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol.  Int J Cancer  2005  115(5):839-46  PubMed ID: 15723336   DOI: 10.1002/ijc.20809
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
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2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424   DOI: 10.1074/jbc.M401881200
2708  Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153  
5416  Araki K, Hashimoto K, Ardyanto TD, Osaki M, Shomori K, Nakamura H, Ito H.  Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas.  Lung Cancer  2004  45(2):161-9  PubMed ID: 15246187   DOI: 10.1016/j.lungcan.2004.01.013
2931  Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, KeQin X, Masuda A, Takahashi T, Kitamura H.  K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.  Am J Pathol  2004  164(1):91-100  PubMed ID: 14695323   DOI: 10.1016/S0002-9440(10)63100-8
3191  Akasaki K1, Nakamura N, Tsukui N, Yokota S, Murata S, Katoh R, Michihara A, Tsuji H, Marques ET Jr, August JT.  Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes.  Arch Biochem Biophys  2004  425(2):147-57  PubMed ID: 15111122   DOI: 10.1016/j.abb.2004.02.042
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9043  Hironaga Kamiyama, Kunikazu Kurosaki, Masanori Kurimoto, Toyomasa Katagiri, Yusuke Nakamura, Masahiko Kurokawa, Hitoshi Sato, Shunro Endo, Kimiyasu Shiraki  Herpes Simplex Virus-Induced, Death Receptor-Dependent Apoptosis and Regression of Transplanted Human Cancers  Cancer Sci  2004  95 (12), 990-8  PubMed ID: 15596049   DOI: 10.1111/j.1349-7006.2004.tb03188.x
12847  Ishii T, Teramoto S, Matsuse T.  GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells  Cancer Lett  2004  216(1):89-102  PubMed ID: 15500952   DOI: 10.1016/j.canlet.2004.05.018
16491  Nakanishi H, Suda T, Katoh M, Watanabe A, Igishi T, Kodani M, Matsumoto S, Nakamoto M, Shigeoka Y, Okabe T, Oshimura M, Shimizu E.  Loss of imprinting of PEG1/MEST in lung cancer cell lines  Oncol Rep  2004  12(6):1273-8  PubMed ID: 15547750  
16648  Konishi J, Yamazaki K, Yokouchi H, Shinagawa N, Iwabuchi K, Nishimura M.  The characteristics of human NKT cells in lung cancer--CD1d independent cytotoxicity against lung cancer cells by NKT cells and decreased human NKT cell response in lung cancer patients  Hum Immunol  2004  65(11):1377-88  PubMed ID: 15556688   DOI: 10.1016/j.humimm.2004.09.003
18706  Simamura E, Hirai K, Shimada H, Pan J, Koyama J.  Mitochondrial damage prior to apoptosis in furanonaphthoquinone treated lung cancer cells  Cancer Detect Prev  2003  27(1):5-13  PubMed ID: 12600411   DOI: 10.1016/s0361-090x(02)00174-5
2659  Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA.  E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.  Mol Cancer Res  2003  1(6):438-44  PubMed ID: 12692263  
6401  Tsuchiya Y, Nakajima M, Itoh S, Iwanari M, Yokoi T.  Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines.  Toxicol Sci  2003  72(2):253-9  PubMed ID: 12655030   DOI: 10.1093/toxsci/kfg022
3594  Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E.  Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.  Int J Oncol  2003  23(4):1079-85  PubMed ID: 12963988  
3592  Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, Kitamura T, Murakami Y.  Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.  Oncogene  2003  22(40):6160-5  PubMed ID: 13679854   DOI: 10.1038/sj.onc.1206744
9039  Masako Tanabe, Mitsue Kurita-Taniguchi, Kaoru Takeuchi, Makoto Takeda, Minoru Ayata, Hisashi Ogura, Misako Matsumoto, Tsukasa Seya  Mechanism of Up-Regulation of Human Toll-like Receptor 3 Secondary to Infection of Measles Virus-Attenuated Strains  Biochem Biophys Res Commun  2003  311 (1), 39-48  PubMed ID: 14575692   DOI: 10.1016/j.bbrc.2003.09.159
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16535  Matsuoka K, Isowa N, Yoshimura T, Liu M, Wada H.  Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells  Cytokine  2002  18(5):266-73  PubMed ID: 12161102   DOI: 10.1006/cyto.2002.1038
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