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細胞番号 : 細胞名
RCB0098 : A549  update : 2021/09/16
細胞特性(Comment:英)Human cell line derived from lung cancer.
細胞特性(日)ヒト肺癌由来細胞株。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Abe, Shin-ichiro
樹立者 Giard, D. J.
寄託日 1986
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
採取組織 lung
病名 adenocarcinoma
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0023
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP, G6PD
染色体検査 59-64(50) : 59(3),60(2),61(8),62(21),63(14),64(2)
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 2件
Reference(日) 1件
利用者成果(英) 200件
利用者成果(日) 0件

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Reference(英)
2114  Honma M, Hayashi M, Ohno T, Mizusawa H, Saijo K, Sofuni T.  Heterogeneity of the Y chromosome following long-term culture of the human lung cancer cell line A549.  In Vitro Cell Dev Biol Anim  1996  32(5):262-4  PubMed ID: 8792154
4609  Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G.  A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.  Int J Cancer  1976  17(1):62-70  PubMed ID: 175022

トップへページトップへ
Reference(日)
1708  清水信義  ヒト腺癌 : A549  生体の科学  1992  43:395 

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利用者成果(英)
15455  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells  Metallomics  2915  7(5):816-27  PubMed ID: 25781390
12851  Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M.  Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M  Bioorg Chem  2021  107:104627  PubMed ID: 33476868
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667
20016  Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T.  Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.  Sci Rep  2021  11(1):1492  PubMed ID: 33452347
20076  Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K.  Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines.  Biochem Biophys Rep  2021  26:100946  PubMed ID: 33644423
13718  Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H.  miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells  Mol Biol Rep  2021  Mar 6  PubMed ID: 33675467
13912  Yamamoto S, Nakanishi J.  Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle  Anal Sci  2021  37(5):741-745  PubMed ID: 33390415
20145  Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R.  Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.  J Nat Med  2021    PubMed ID: 33928494
20147  Kariya Y, Oyama M, Suzuki T, Kariya Y.  αvβ3 Integrin induces partial EMT independent of TGF-β signaling.  Commun Biol  2021  4(1):490  PubMed ID: 33883697
14339  Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S.  GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection  mBio  2021  e0326920  PubMed ID: 34061598
20205  Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K.  Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.  Food Chem Toxicol  2021  154:112319  PubMed ID: 34087405
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2021  e1485  PubMed ID: 34173723
20278  Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A.  Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.  Eur J Med Chem  2021  215:113288  PubMed ID: 33640763
15273  Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T.  Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse  Prostaglandins Other Lipid Mediat  2021  Jul 9  PubMed ID: 34252545
15415  Michihito Sasaki, Mai Kishimoto, Yukari Itakura, Koshiro Tabata, Kittiya Intaruck, Kentaro Uemura, Shinsuke Toba, Takao Sanaki, Akihiko Sato, William W. Hall, Yasuko Orba, Hirofumi Sawa  Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells  Biochemical and Biophysical Research Communications  2021  577:146-151 
13432  Kenta Shinha, Wataru Nihei, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies  Biomicrofluidics  2020/1/1   
6923  Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.  Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells.  Biochim Biophys Acta Mol Cell Res.  2020  1867(4):118642  PubMed ID: 31923533
9729  Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto  Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts  Exp Cell Res  2020  391(2):112010  PubMed ID: 32305327
9819  Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto  Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis  Biosci Biotechnol Biochem  2020  84(4):757-763  PubMed ID: 31868102
11986  Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K.  Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.  J. Radiat. Res.  2020  61(2):237-242.  PubMed ID: 31904079
12065  Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T.  Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2020    PubMed ID: 32112978
12375  Morita S, Horii T, Kimura M, Hatada I.  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform  Int J Mol Sci   2020  21(5):1574  PubMed ID: 32106616
12376  Uddin M, Kawami M, Yumoto R, Takano M.  Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells  Naunyn Schmiedebergs Arch Pharmacol  2020  393(5):889-896  PubMed ID: 31900520
12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206
12989  Endo M, Ohba K, Sato S, Yokota Y, Takahashi K.  Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells.  Genes Cells  2020    PubMed ID: 32314441
12990  Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A.  Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression.  Nutrients  2020    PubMed ID: 32340376
12998  Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H.  Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.  Appl Radiat Isot  2020    PubMed ID: 32561042
13002  Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K.  Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway.  Respir Investig  2020    PubMed ID: 32359980
13021  Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K.  Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation.  PLoS One  2020    PubMed ID: 32374749
13089  Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y.  Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.  Sci Rep  2020    PubMed ID: 32612147
13167  Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N.  Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy.  Biochem Biophys Res Commun  2020    PubMed ID: 32828300
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095
13260  Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y.  Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.  Immun Inflamm Dis  2020    PubMed ID: 33016012
13295  Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y.  Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells.  Oncol Lett  2020    PubMed ID: 33133262
13342  Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N.  Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity.  Nanomaterials (Basel)  2020    PubMed ID: 33202926
13523  Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori  Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549  bioRxiv  2020  October 04 
13535  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  DNA Repair (Amst)  2020  91-92:102872  PubMed ID: 32502756
13568  Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI)  Authorea Preprints  2020   
13622  Sato Y, Yoshino H, Tsuruga E, Kashiwakura I.  Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation  Curr Cancer Drug Targets  2020  20(5):372-381  PubMed ID: 31951181
13767  Togami K, Yamaguchi K, Tada H, Chono S.  Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis  Pharmazie  2020  75(8):371-374  PubMed ID: 32758335
13841  Eguchi R, Wakabayashi I.  HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer  Oncol Rep  2020  44(1):14-28  PubMed ID: 32319650
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677
14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240
14849  Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H.  The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD  Free Radic Res  2020  54(11-12):829-840  PubMed ID: 31809610
11371  Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K.  Formation of high molecular weight p62 by CORM-3.  PLoS ONE  2019    PubMed ID: 30620762
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060
4759  Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita  Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity  Molecules  2019  24:3535  PubMed ID: 31574910
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272
11675  Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi  Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging  CHEMNANOMAT  2019   
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114
10357  Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci  Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors  Eur J Med Chem  2019  82:111648  PubMed ID: 31493743
12378  Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.  CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development  Oncogene  2019  38(14):2580-2594  PubMed ID: 30531840
12379  Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M.  Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis  Clin Cancer Res  2019  25(9):2809-2820  PubMed ID: 30728155
12380  Chinnathambi S, Hanagata N.  Photostability of quantum dot micelles under ultraviolet irradiation  Luminescence  2019  34(5):472-479  PubMed ID: 30809921
12381  Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI.  Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake  Photodiagnosis Photodyn Ther  2019  27:327-335  PubMed ID: 31252141
12382  Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F.  Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma  Cancer Sci  2019  110(2):726-733  PubMed ID: 30499156
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323
10803  Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M.  Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions.  Lab Chip  2018  18:1378-1387  PubMed ID: 29658964
10805  Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H.  Effects of cationic liposomes with stearylamine against virus infection.  Int J Pharm  2018  543:311-317  PubMed ID: 29625169
11049  Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H  The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection.  J Infect Dis  2018  217(11):1740-1749  PubMed ID: 29529215
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296
11177  Kobayashi A, Konishi T.  Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells.  J. Radiat. Res.  2018  59(6):754-759  PubMed ID: 30124879
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880
4072  Takayuki Hirono et al  MiR-301a/b function as oncomiRs in non-small-cell lung cancer  Integr Mol Med  2018  5: 1-6 
4097  Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H.  Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay.  Virus Res  2018  243:69-74  PubMed ID: 29074234
4132  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.  Cytotechnology  2018    PubMed ID: 28756527
4133  Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K.  Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis.  Lung  2018    PubMed ID: 29926178
4134  Sato Y, Yoshino H, Kazama Y, Kashiwakura I.  Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer.  Mol Med Rep  2018    PubMed ID: 30320341
4135  Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y.  CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30448176
4136  Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.  Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.  Tohoku J. Exp. Med.  2018    PubMed ID: 29459573
4137  Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H.  In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.  Int. J. Biol. Macromol.  2018    PubMed ID: 28964842
4138  Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O.  Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30446226
4139  Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M.  High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma.  Pathol. Int.  2018    PubMed ID: 30320419
4141  Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C.  Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.  Oncotarget  2018    PubMed ID: 30220973
4468  Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y.  A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells.  Medchemcomm  2018  9(5):783-788  PubMed ID: 30108967
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165
10280  Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A.  AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier.  Oncol. Rep.  2017  37:3261-3269  PubMed ID: 28440492
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138
10924    Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin  RSC Adv  2017  7, 2392-2402 
4526  Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata  Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells  Mutation Research/Genetic Toxicology and Environmental Mutagenesis  2017  818, 7-16  PubMed ID: 28477879
9171  Haruhiko Fuwa, Mizuho Sato  A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells  Mar Drugs  2017  15 (10)  PubMed ID: 29053565
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625
12218  Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada  Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis  J Pharmacol Toxicol Methods  2017  86:19-27.  PubMed ID: 28259823
14030  El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M.  Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2  Biomed Pharmacother  2017  85:549-555  PubMed ID: 27889230
14081  Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H.  IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models  Allergy  2017  72(7):1043-1053.   PubMed ID: 27878831
14432  Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M.  miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma  Cancer Sci  2017  108(3):536-542  PubMed ID: 28012229
14529  Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R.  Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells  Radiat Res  2017  188(5):591-594  PubMed ID: 28829673
14665  Takahashi K, Ohta T.  Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells  Biochem Biophys Res Commun  2017  490(3):587-593  PubMed ID: 28629997
14674  Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y.  Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy  J Am Chem Soc  2017  139(39):13713-13719  PubMed ID: 28872304
14730  Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T.  Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells  Sci Rep  2017  7(1):12317.  PubMed ID: 28951614
14734  TOMOMI SANOMACHI et al  Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents  Anticancer Research  2017  37:6177-6188 
7063  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.  Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.  Nat. Biotechnol.  2016  34:1060-1065  PubMed ID: 27571369
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807
9774  Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H.  Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.  Virus Res.  2016  223:170-80  PubMed ID: 27485920
9884  Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C.  Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.  Anticancer Res.  2016  36:6083-6092  PubMed ID: 27793936
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591
10117  Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka  Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy  Biomater Sci .   2016  4(5):826-38  PubMed ID: 26971562
12614  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage  J Biochem  2016  159(2):225-37  PubMed ID: 26378248
12629  Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine  Anticancer Res  2016  36(12):6311-6318  PubMed ID: 27919951
12630  Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.  The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo  Oncotarget  2016  7(19):27021-32  PubMed ID: 27027242
12631  Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J.  Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer  Transl Oncol  2016  9(3):203-10  PubMed ID: 27267838
12646  Husni RE, Shiba-Ishii A, Iiyama S, Shiozawa T, Kim Y, Nakagawa T, Sato T, Kano J, Minami Y, Noguchi M.  DNMT3a expression pattern and its prognostic value in lung adenocarcinoma  Lung Cancer  2016  97:59-65  PubMed ID: 27237029
12681  Toyama K, Mizuguchi T, Nomura W, Tamamura H.  Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization  Bioorg Med Chem  2016  24(16):3406-12  PubMed ID: 27283787
12948  Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K.  Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2  Cancer Sci  2016  107(9):1321-8  PubMed ID: 27324116
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853
12974  Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M.  Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation  Part Fibre Toxicol  2016  13:16  PubMed ID: 27026438
13469  Tanabe K.  Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization  Sci Rep  2016  6:25095  PubMed ID: 27117592
13976  Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R.  Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair  Cancer Sci  2016  107(9):1250-5  PubMed ID: 27341700
13996  Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M.  Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers  Bioconjug Chem  2016  27(10):2307-2314  PubMed ID: 27580353
14026  Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance  Anticancer Res  2016  36(10):5153-5161  PubMed ID: 27798875
14028  Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.  A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam  PLoS One  2016  11(11):e0166848  PubMed ID: 27875573
14041  Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T.  Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark  Chem Biodivers  2016  13(11):1601-1609  PubMed ID: 27492128
14095  Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida  Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells  Nanoscience and Nanotechnology Letters  2016  8:310-315 
5653  Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H.  Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.  Anticancer Res  2015  35(8):4411-7  PubMed ID: 26168480
14286  Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N.  Prognostic significance of MYH9 expression in resected non-small cell lung cancer  PLoS One  2015  10(3):e0121460  PubMed ID: 25826333
14460  Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I.  Effects of X‑ray irradiation in combination with ascorbic acid on tumor control  Mol Med Rep  2015  12(4):5449-54  PubMed ID: 26238154
14953  Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y.  A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents  Anticancer Res  2015  35(11):5851-5  PubMed ID: 26504007
15015  Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E.  Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells  Yonago Acta Med  2015  58(1):31-8  PubMed ID: 26190895
15069  Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T.  Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels  Chem Biodivers  2015  12(4):547-58  PubMed ID: 25879500
15117  Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A.  Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer  Mol Cancer Ther  2015  14(11):2433-40  PubMed ID: 26351321
15198  Pauli G, Aepfelbacher M, Bauerfeind U, Blümel J, Burger R, Gärtner B, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Strobel J, Willkommen H, Baylis SA, German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’.  Hepatitis E Virus  Transfus Med Hemother  2015  2(4):247-65.  PubMed ID: 26557817
6014  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H.  Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.  J Gen Virol  2014  95(Pt 10):2166-75  PubMed ID: 24970738
13754  Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T.  Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma  Int J Oncol   2014  44(4):1118-30  PubMed ID: 24481417
3914  Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai  Cancer cells uptake porphyrins via heme carrier protein 1  Journal of Porphyrins and Phthalocyanines  2013  17:36-43 
5376  Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H.  Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.  Eur J Pharm Biopharm  2012  80(2):340-6  PubMed ID: 22036988
5620  Tabata A, Ohkubo Y, Sakakura E, Tomoyasu T, Ohkura K, Nagamune H.  Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool.  Anticancer Res  2012  32(6):2323-9  PubMed ID: 22641669
6432  Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H.  Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells.  Virus Res  2012  170(1-2):126-37  PubMed ID: 23041252
12718  Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.  Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells  Biochim Biophys Acta  2012  1823(6):1110-8  PubMed ID: 22546605
12726  Muroya M, Chang K, Uchida K, Bougaki M, Yamada Y.  Analysis of cytotoxicity induced by proinflammatory cytokines in the human alveolar epithelial cell line A549  Biosci Trends  2012  6(2):70-80  PubMed ID: 22621989
7717  Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y.  GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.  Chem. Res. Toxicol.  2011  24:1836-44  PubMed ID: 21827172
7806  Hoshino A, Ishii G, Ito T, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A.  Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.  Cancer Res.  2011  71:4769-79  PubMed ID: 21610106
7900  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery.  Chem. Pharm. Bull.  2011  59:298-301  PubMed ID: 21372409
7951  Okamoto H.  Hepatitis E virus cell culture models.  Virus Res.  2011  161:65-77  PubMed ID: 21316402
8125  Ishigaki Y, Nakamura Y, Takehara T, Nemoto N, Kurihara T, Koga H, Nakagawa H, Takegami T, Tomosugi N, Miyazawa S, Kuwabata S.  Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis.  Microsc. Res. Tech.  2011  74:415-20  PubMed ID: 20830703
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202
5863  Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y.  The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.  Biomaterials  2011  32(26):6052-8  PubMed ID: 21640378
6008  Horie M, Kato H, Endoh S, Fujita K, Nishio K, Komaba LK, Fukui H, Nakamura A, Miyauchi A, Nakazato T, Kinugasa S, Yoshida Y, Hagihara Y, Morimoto Y, Iwahashi H.  Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.  Metallomics  2011  3(11):1244-52  PubMed ID: 21804981
9083  Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai  Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis  Infect Immun  2011  79 (11), 4353-60  PubMed ID: 21911469
12748  Ikari A, Sato T, Takiguchi A, Atomi K, Yamazaki Y, Sugatani J.  Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells  Life Sci  2011  88(13-14):628-33  PubMed ID: 21315735
8043  Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T.  Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.  J. Pharmacol. Sci.  2010  114:420-32  PubMed ID: 21127389
8176  Haruki T, Shomori K, Hamamoto Y, Taniguchi Y, Nakamura H, Ito H.  Geminin expression in small lung adenocarcinomas: implication of prognostic significance.  Lung Cancer  2010  71:356-62  PubMed ID: 20650542
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387
8238  Horie M, Nishio K, Fujita K, Kato H, Endoh S, Suzuki M, Nakamura A, Miyauchi A, Kinugasa S, Yamamoto K, Iwahashi H, Murayama H, Niki E, Yoshida Y.  Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.  Toxicol In Vitro  2010  24:1629-38  PubMed ID: 20541599
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349
11378  T. Ohnuma, T. Matsumoto, T. Komats, T. Nishiyama, K. Ogura, H. Iwata, A. Hiratsuka  Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxification of electrophiles and lung cancer chemotherapy.  J Traditional Medicines  2010  27:122-133 
8436  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents of propolis from Myanmar and their structure-activity relationship.  Biol. Pharm. Bull.  2009  32:2075-8  PubMed ID: 19952433
8489  Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T.  Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.  J. Pharmacol. Sci.  2009  111:182-92  PubMed ID: 19783865
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8523  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.  Int J Pharm  2009  382:198-204  PubMed ID: 19646519
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8626  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.  Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.  Cancer  2009  115:2580-93  PubMed ID: 19309748
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8688  Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa  Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells  Journal of Health Science  2009  55:845-850 
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655
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