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Cell No. : Cell Name
RCB0098 : A549  update : 2024/05/21
CommentHuman cell line derived from lung cancer.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Abe, Shin-ichiro
Originator Giard, D. J.
Year of deposit 1986
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Tissue lung
Disease name adenocarcinoma
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0023
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP, G6PD
Chromosome mode 59-64(50) : 59(3),60(2),61(8),62(21),63(14),64(2)
STR(human) OK
deposit info
lot info
Reference information Reference 1
User's Publication 355

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4609  Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G.  A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.  Int J Cancer  1976  17(1):62-70  PubMed ID: 175022   DOI: 10.1002/ijc.2910170110

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User's Publication
21542  Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A.  RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality.  J Am Chem Soc  2024    PubMed ID: 38170469   DOI: 10.1021/jacs.3c09524
21618  Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T.  PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.  J Biol Chem  2024  300(1):105584  PubMed ID: 38141761   DOI: 10.1016/j.jbc.2023.105584
21652  Yoshida T, Goto K, Kodama A, Bolidong D, Seto T, Hanayama R.  Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity.  Arch Biochem Biophys  2024  755:109964  PubMed ID: 38527699   DOI: 10.1016/
17622  Maruyama S, Sakabe N, Ito C, Shimoyama Y, Sato S, Ikeda K.  Effect of Specimen Processing Technique on Cell Detection and Classification by Artificial Intelligence  Am J Clin Pathol  2023  aqac178  PubMed ID: 36933198   DOI: 10.1093/ajcp/aqac178
17769  Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H.  Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone  Viruses  2023  15(4):845  PubMed ID: 37112827   DOI: 10.3390/v15040845
17785  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K.  Relationship between a deep learning model and liquid-based cytological processing techniques  Cytopathology  2023  Apr 13  PubMed ID: 37051774   DOI: 10.1111/cyt.13235
17792  Ryo Doge, Yuki Nishino, Akiko Saito  Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria  BioChem  2023  3:61-77    DOI: 10.3390/biochem3020005
17808  Sato Y, Yoshino H, Sato K, Kashiwakura I, Tsuruga E.  DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines  J Radiat Res  2023  rrad016  PubMed ID: 37023702   DOI: 10.1093/jrr/rrad016
17814  Tamai M, Taba S, Mise T, Yamashita M, Ishikawa H, Shintake T.  Ethanol vapor inhalation treatment inhibits lethal respiratory viral infection with Influenza A  J Infect Dis  2023  jiad089  PubMed ID: 37101418   DOI: 10.1093/infdis/jiad089
17816  Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe  In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters  EJNMMI Research  2023  13    DOI: 10.1186/s13550-023-00988-1
19547  Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Ishibashi S, Kawashima-Sonoyama Y, Matsuzaki Y, Taketani T.  Extracellular Vesicles and Cx43-Gap Junction Channels Are the Main Routes for Mitochondrial Transfer from Ultra-Purified Mesenchymal Stem Cells, RECs  Int J Mol Sci  2023  24(12):10294  PubMed ID: 37373439   DOI: 10.3390/ijms241210294
19548  Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A.  CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade  Nat Commun  2023  14(1):7490  PubMed ID: 37980406   DOI: 10.1038/s41467-023-43274-3
19549  Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K.  2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses  Proc Natl Acad Sci U S A  2023  120(42):e2304139120  PubMed ID: 37831739   DOI: 10.1073/pnas.2304139120
19550  Oka N, Shimada K, Ishii A, Kobayashi N, Kondo K.  SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production  iScience  2023  26(6):106954  PubMed ID: 37275532   DOI: 10.1016/j.isci.2023.106954
19554  Amma C, Inomata Y, Kohno R, Satake M, Furukawa A, Nagata Y, Sugiyama H, Seto T, Suzuki R.  Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells  Environ Geochem Health  2023  45(8):5879-5891  PubMed ID: 37179508   DOI: 10.1007/s10653-023-01599-4
19555  Kobayashi A, Hiroyama Y, Mamiya T, Oikawa M, Konishi T.  The COX-2/PGE2 Response Pathway Upregulates Radioresistance in A549 Human Lung Cancer Cells through Radiation-Induced Bystander Signaling  Biology (Basel)  2023  12(11):1368  PubMed ID: 37997966   DOI: 10.3390/biology12111368
19605  Zhang D, Shimokawa T, Guo Q, Dan S, Miki Y, Sunada S.  Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break  Cancer Sci  2023  114(3):1108-1117.  PubMed ID: 36385507   DOI: 10.1111/cas.15659
19918  Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I.  Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation  Toxicol Mech Methods  2023  33(9):741-754  PubMed ID: 37496379   DOI: 10.1080/15376516.2023.2238061
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
19976  Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK.  Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer  J Med Chem  2023  Dec 17  PubMed ID: 38105611   DOI: 10.1021/acs.jmedchem.3c01493
21065  Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A.  Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.  J Am Chem Soc  2023  145(1):135-142  PubMed ID: 36538570   DOI: 10.1021/jacs.2c08974
21080  Miura K, Koyanagi-Aoi M, Maniwa Y, Aoi T.  Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis.  Cancer Cell Int  2023  23(1):34  PubMed ID: 36841751   DOI: 10.1186/s12935-023-02870-5
21168  Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T.  Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer.  Stem Cell Res Ther  2023  14(1):40  PubMed ID: 36927781   DOI: 10.1186/s13287-023-03274-y
21185  Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S.  Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.  Drug Deliv  2023  30(1):2191891  PubMed ID: 36964673   DOI: 10.1080/10717544.2023.2191891
21259  Takata J, Kiura K, Nakasuka T, Hirabae A, Arimoto-Kobayashi S.  Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice.  Genes Environ  2023  45(1):19  PubMed ID: 37280663   DOI: 10.1186/s41021-023-00276-3
21379  Hata M, Ueno J, Hitomi Y, Kodera M.  Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.  ACS Omega  2023  8(31):28690-28701  PubMed ID: 37576680   DOI: 10.1021/acsomega.3c03387
21380  Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I.  Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia.  Anticancer Res  2023  43(8):3429-3439  PubMed ID: 37500171   DOI: 10.21873/anticanres.16518
21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3
21526  Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H.  Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells.  Eur J Pharmacol  2023  960:176156  PubMed ID: 38059445   DOI: 10.1016/j.ejphar.2023.176156
21547  Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T.  Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions.  Biology (Basel)  2023  12(12)  PubMed ID: 38132311   DOI: 10.3390/biology12121485
17494  Maeda A, Fujimura T, Hirakawa N, Baba K, Kawamoto S.  A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells  Biol Pharm Bull  2022  45(10):1581-1584  PubMed ID: 35979561   DOI: 10.1248/bpb.b22-00310
17595  Maki M, JeongMin H, Nakagawa T, Kawai H, Sakamoto N, Sato Y, Noguchi M.  Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome  Pathol Int  2022  72(10):496-505  PubMed ID: 35920378   DOI: 10.1111/pin.13262
17647  Tamari S, Menju T, Toyazaki T, Miyamoto H, Chiba N, Noguchi M, Ishikawa H, Miyata R, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Ohsumi A, Hamaji M, Date H.  Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer  Oncol Rep  2022  48(4):171  PubMed ID: 35959810   DOI: 10.3892/or.2022.8386
18224  Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S.  Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53  Chem Res Toxicol  2022  35(9):1598-1603  PubMed ID: 36027604   DOI: 10.1021/acs.chemrestox.2c00202
13435  Funato N, Yanagisawa H.  TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties  Sci Rep  2022  12(1):20188  PubMed ID: 36418889   DOI: 10.1038/s41598-022-24604-9
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2022  e1485  PubMed ID: 34173723   DOI: 10.1002/cnr2.1485
20391  Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H.  Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs.  J Biosci Bioeng  2022    PubMed ID: 34789413   DOI: 10.1016/j.jbiosc.2021.10.001
20408  Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K.  Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology.  Acta Cytol  2022  1-6  PubMed ID: 34644702   DOI: 10.1159/000519335
20410  Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.  Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.  Radiat Res  2022    PubMed ID: 34634126   DOI: 10.1667/RADE-21-00112.1
20486  Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y.  Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.  Oncol Rep  2022  47(2)  PubMed ID: 34935060   DOI: 10.3892/or.2021.8243
16353  Tsujiya Y, Hasegawa A, Yamamori M, Okamura N.  Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines  Biol Pharm Bull  2022  45(3):276-283  PubMed ID: 35228393   DOI: 10.1248/bpb.b21-00785
20590  Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T.  High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells.  Molecules  2022  27(4)  PubMed ID: 35209077   DOI: 10.3390/molecules27041287
20595  Matsushige T, Sakabe T, Umekita Y.  Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line.  Yonago Acta Med  2022  65(1):44-52  PubMed ID: 35221759   DOI: 10.33160/yam.2022.02.006
20613  Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.  Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.  Analyst  2022    PubMed ID: 35297918   DOI: 10.1039/d2an00052k
20674  Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y.  The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets.  Cell Rep  2022  39(4):110721  PubMed ID: 35476996   DOI: 10.1016/j.celrep.2022.110721
20684  Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O.  Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis.  Transl Oncol  2022  21:101431  PubMed ID: 35452996   DOI: 10.1016/j.tranon.2022.101431
16485  Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M.  Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration  Int J Mol Sci  2022  23(9):5047  PubMed ID: 35563439   DOI: 10.3390/ijms23095047
16496  Siswanto FM, Tamura A, Sakuma R, Imaoka S.  Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway  Mol Pharmacol  2022  101(4):257-273  PubMed ID: 35193967   DOI: 10.1124/molpharm.121.000475
16710  Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka  A vitamin D C/D ring-derived compound with cytotoxicity  Medicinal Chemistry Research  2022  1120-1125    DOI: 10.1007/s00044-021-02842-2
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20808  Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka  A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity  Chemical and Pharmaceutical Bulletin  2022  477-482  PubMed ID: 35786566   DOI: 10.1248/cpb.c21-01087
16959  Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita  Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells  Medicinal Chemistry Research  2022  31:1584-1593    DOI: 10.1007/s00044-022-02939-2
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20896  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K.  Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network.  Acta Cytol  2022  1-9  PubMed ID: 36067744   DOI: 10.1159/000526098
20912  Kotani N, Nakano T, Kuwahara R.  Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis.  J Biol Chem  2022  298(11):102500  PubMed ID: 36152751   DOI: 10.1016/j.jbc.2022.102500
20963  Takata J, Miyake N, Saiki Y, Tada M, Sasaki K, Kubo T, Kiura K, Arimoto-Kobayashi S.  Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse.  Genes Environ  2022  44(1):26  PubMed ID: 36494703   DOI: 10.1186/s41021-022-00255-0
12851  Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M.  Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M  Bioorg Chem  2021  107:104627  PubMed ID: 33476868   DOI: 10.1016/j.bioorg.2021.104627
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667   DOI: 10.3892/or.2020.7839
20016  Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T.  Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.  Sci Rep  2021  11(1):1492  PubMed ID: 33452347   DOI: 10.1038/s41598-021-81077-y
20076  Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K.  Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines.  Biochem Biophys Rep  2021  26:100946  PubMed ID: 33644423   DOI: 10.1016/j.bbrep.2021.100946
13718  Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H.  miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells  Mol Biol Rep  2021  Mar 6  PubMed ID: 33675467   DOI: 10.1007/s11033-021-06255-7
13912  Yamamoto S, Nakanishi J.  Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle  Anal Sci  2021  37(5):741-745  PubMed ID: 33390415   DOI: 10.2116/analsci.20SCP16
20145  Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R.  Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.  J Nat Med  2021    PubMed ID: 33928494   DOI: 10.1007/s11418-021-01519-9
20147  Kariya Y, Oyama M, Suzuki T, Kariya Y.  αvβ3 Integrin induces partial EMT independent of TGF-β signaling.  Commun Biol  2021  4(1):490  PubMed ID: 33883697   DOI: 10.1038/s42003-021-02003-6
14339  Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S.  GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection  mBio  2021  e0326920  PubMed ID: 34061598   DOI: 10.1128/mBio.03269-20
20205  Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K.  Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.  Food Chem Toxicol  2021  154:112319  PubMed ID: 34087405   DOI: 10.1016/j.fct.2021.112319
20278  Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A.  Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.  Eur J Med Chem  2021  215:113288  PubMed ID: 33640763   DOI: 10.1016/j.ejmech.2021.113288
15273  Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T.  Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse  Prostaglandins Other Lipid Mediat  2021  Jul 9  PubMed ID: 34252545   DOI: 10.1016/j.prostaglandins.2021.106580
15490  Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.  LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence  Transl Oncol  2021  14(11):101212  PubMed ID: 34461558   DOI: 10.1016/j.tranon.2021.101212
15504  Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y.  DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency  Nat Commun  2021  12(1):5041  PubMed ID: 34413299   DOI: 10.1038/s41467-021-25249-4
20362  Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H.  Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells.  Biochem Biophys Res Commun  2021  577:146-151  PubMed ID: 34517212   DOI: 10.1016/j.bbrc.2021.09.015
20363  Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C.  Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin.  Anticancer Res  2021  41(9):4321-4331  PubMed ID: 34475052   DOI: 10.21873/anticanres.15237
20367  Kariya Y, Oyama M, Kariya Y, Hashimoto Y.  Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.  Biomolecules  2021  11(9)  PubMed ID: 34572536   DOI: 10.3390/biom11091323
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032   DOI: 10.1016/j.heliyon.2021.e08318
20423  Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T.  Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells.  Histochem Cell Biol  2021  155(6):637-653  PubMed ID: 33974136   DOI: 10.1007/s00418-021-01966-1
15879  Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.  5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2  iScience  2021  24(10):103120  PubMed ID: 34541466   DOI: 10.1016/j.isci.2021.103120
15881  Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS.  SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis  Nat Commun  2021  12(1):6602  PubMed ID: 34782627   DOI: 10.1038/s41467-021-26910-8
20510  Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N.  Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device.  Toxics  2021  9(12)  PubMed ID: 34941765   DOI: 10.3390/toxics9120331
16119  Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y.  Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation  Pathol Int  2021  71(1):15-23  PubMed ID: 33112501   DOI: 10.1111/pin.13040
16128  Sato Y, Yoshino H, Kashiwakura I, Tsuruga E.  DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells  Int J Mol Sci  2021  22(1):420  PubMed ID: 33401559   DOI: 10.3390/ijms22010420
16219  Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto  Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma  Cancer Sci  2021  112(12):5114-5126  PubMed ID: 34628698   DOI: 10.1111/cas.15160
16225  M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki  Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells  Folia Biol (Praha)  2021  67(2):62-69.  PubMed ID: 34624938  
16231  Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A.  Upregulation of Chemoresistance by Mg 2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells  Cells  2021  10(5):1179  PubMed ID: 34066059   DOI: 10.3390/cells10051179
16523  Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami  Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis  Particle & Particle Systems Characterization  2021  38:2100003    DOI: 10.1002/ppsc.202100003
17827  Hirofumi Kurita, Yoshie Minamijima, Kazunori Takashima  Characterization of intracellular reactive species production stimulated by cold atmospheric pressure plasma irradiation  Int. J. Plasma Environ. Sci. Technol  2020  14:e03003 (9pp)    DOI: 10.34343/ijpest.2020.14.e03003
6923  Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.  Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells.  Biochim Biophys Acta Mol Cell Res.  2020  1867(4):118642  PubMed ID: 31923533   DOI: 10.1016/j.bbamcr.2019.118642
9729  Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto  Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts  Exp Cell Res  2020  391(2):112010  PubMed ID: 32305327   DOI: 10.1016/j.yexcr.2020.112010
9819  Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto  Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis  Biosci Biotechnol Biochem  2020  84(4):757-763  PubMed ID: 31868102   DOI: 10.1080/09168451.2019.1706442
11986  Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K.  Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.  J. Radiat. Res.  2020  61(2):237-242.  PubMed ID: 31904079   DOI: 10.1093/jrr/rrz098
12065  Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T.  Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2020    PubMed ID: 32112978   DOI: 10.1016/j.bbalip.2020.158675
12375  Morita S, Horii T, Kimura M, Hatada I.  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform  Int J Mol Sci   2020  21(5):1574  PubMed ID: 32106616   DOI: 10.3390/ijms21051574
12376  Uddin M, Kawami M, Yumoto R, Takano M.  Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells  Naunyn Schmiedebergs Arch Pharmacol  2020  393(5):889-896  PubMed ID: 31900520   DOI: 10.1007/s00210-019-01802-3
12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206   DOI: 10.3727/096504019X15736439848765
12989  Endo M, Ohba K, Sato S, Yokota Y, Takahashi K.  Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells.  Genes Cells  2020    PubMed ID: 32314441   DOI: 10.1111/gtc.12776
12990  Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A.  Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression.  Nutrients  2020    PubMed ID: 32340376   DOI: 10.3390/nu12041190
12998  Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H.  Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.  Appl Radiat Isot  2020    PubMed ID: 32561042   DOI: 10.1016/j.apradiso.2020.109201
13002  Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K.  Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway.  Respir Investig  2020    PubMed ID: 32359980   DOI: 10.1016/j.resinv.2020.01.003
13021  Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K.  Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation.  PLoS One  2020    PubMed ID: 32374749   DOI: 10.1371/journal.pone.0232724
13089  Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y.  Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.  Sci Rep  2020    PubMed ID: 32612147   DOI: 10.1038/s41598-020-67488-3
13167  Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N.  Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy.  Biochem Biophys Res Commun  2020    PubMed ID: 32828300   DOI: 10.1016/j.bbrc.2020.07.082
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095   DOI: 10.1080/03639045.2020.1825473
13260  Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y.  Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.  Immun Inflamm Dis  2020    PubMed ID: 33016012   DOI: 10.1002/iid3.355
13295  Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y.  Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells.  Oncol Lett  2020    PubMed ID: 33133262   DOI: 10.3892/ol.2020.12226
13342  Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N.  Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity.  Nanomaterials (Basel)  2020    PubMed ID: 33202926   DOI: 10.3390/nano10112250
13432  Kenta Shinha, Wataru Nihei, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies  Biomicrofluidics  2020      DOI: 10.1063/5.0011545
13523  Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori  Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549  bioRxiv  2020  October 04    DOI: 10.1101/2020.10.02.323881
13535  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  DNA Repair (Amst)  2020  91-92:102872  PubMed ID: 32502756   DOI: 10.1016/j.dnarep.2020.102872
13568  Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI)  Authorea Preprints  2020      DOI: 10.22541/au.158316431.10469346
13622  Sato Y, Yoshino H, Tsuruga E, Kashiwakura I.  Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation  Curr Cancer Drug Targets  2020  20(5):372-381  PubMed ID: 31951181   DOI: 10.2174/1568009620666200115161717
13767  Togami K, Yamaguchi K, Tada H, Chono S.  Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis  Pharmazie  2020  75(8):371-374  PubMed ID: 32758335   DOI: 10.1691/ph.2020.0048
13841  Eguchi R, Wakabayashi I.  HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer  Oncol Rep  2020  44(1):14-28  PubMed ID: 32319650   DOI: 10.3892/or.2020.7580
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240   DOI: 10.1016/j.chembiol.2020.04.007
14849  Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H.  The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD  Free Radic Res  2020  54(11-12):829-840  PubMed ID: 31809610   DOI: 10.1080/10715762.2019.1696965
11371  Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K.  Formation of high molecular weight p62 by CORM-3.  PLoS ONE  2019    PubMed ID: 30620762   DOI: 10.1371/journal.pone.0210474
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060   DOI: 10.1093/rpd/ncy249
4759  Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita  Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity  Molecules  2019  24:3535  PubMed ID: 31574910   DOI: 10.3390/molecules24193535
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272   DOI: 10.1016/j.molcel.2019.09.009
11612  Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.  Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.  Genes Cells  2019    PubMed ID: 31234244   DOI: 10.1111/gtc.12712
11634  Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavichb A, Konishic T.  Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation.  Radiat. Res.  2019    PubMed ID: 30526323   DOI: 10.1667/RR15155.1
11675  Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi  Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging  CHEMNANOMAT  2019      DOI: 10.1002/cnma.201900289
11808  Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M.  Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer.  Anticancer Res.  2019    PubMed ID: 31519584   DOI: 10.21873/anticanres.13667
11848  Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M.  Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs.  Cancers (Basel)  2019    PubMed ID: 31614999   DOI: 10.3390/cancers11101550
11864  Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K.  Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1.  J. Org. Chem.  2019    PubMed ID: 31642324   DOI: 10.1021/acs.joc.9b02304
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114   DOI: 10.3892/ol.2018.9869
10357  Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci  Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors  Eur J Med Chem  2019  82:111648  PubMed ID: 31493743   DOI: 10.1016/j.ejmech.2019.111648
12378  Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.  CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development  Oncogene  2019  38(14):2580-2594  PubMed ID: 30531840   DOI: 10.1038/s41388-018-0603-7
12379  Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M.  Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis  Clin Cancer Res  2019  25(9):2809-2820  PubMed ID: 30728155   DOI: 10.1158/1078-0432.CCR-18-3631
12380  Chinnathambi S, Hanagata N.  Photostability of quantum dot micelles under ultraviolet irradiation  Luminescence  2019  34(5):472-479  PubMed ID: 30809921   DOI: 10.1002/bio.3618
12381  Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI.  Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake  Photodiagnosis Photodyn Ther  2019  27:327-335  PubMed ID: 31252141   DOI: 10.1016/j.pdpdt.2019.06.017
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10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323   DOI: 10.1186/s12885-017-3958-1
10803  Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M.  Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions.  Lab Chip  2018  18:1378-1387  PubMed ID: 29658964   DOI: 10.1039/c7lc01280b
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10924    Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin  RSC Adv  2017  7, 2392-2402    DOI: 10.1039/C6RA26592H
4526  Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata  Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells  Mutation Research/Genetic Toxicology and Environmental Mutagenesis  2017  818, 7-16  PubMed ID: 28477879   DOI: 10.1016/j.mrgentox.2017.04.002
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12213  Cancer Lett  Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells    2017  390:160-167  PubMed ID: 28093283   DOI: 10.1016/j.canlet.2017.01.006
12218  Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada  Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis  J Pharmacol Toxicol Methods  2017  86:19-27.  PubMed ID: 28259823   DOI: 10.1016/j.vascn.2017.02.023
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14674  Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y.  Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy  J Am Chem Soc  2017  139(39):13713-13719  PubMed ID: 28872304   DOI: 10.1021/jacs.7b05019
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16608  Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C.  Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents  Anticancer Res  2017  37(11):6177-6188  PubMed ID: 29061799   DOI: 10.21873/anticanres.12067
7063  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.  Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.  Nat. Biotechnol.  2016  34:1060-1065  PubMed ID: 27571369   DOI: 10.1038/nbt.3658
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9774  Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H.  Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.  Virus Res.  2016  223:170-80  PubMed ID: 27485920   DOI: 10.1016/j.virusres.2016.07.011
9884  Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C.  Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.  Anticancer Res.  2016  36:6083-6092  PubMed ID: 27793936   DOI: 10.21873/anticanres.11198
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591   DOI: 10.1371/journal.pone.0147957
10117  Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka  Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy  Biomater Sci .   2016  4(5):826-38  PubMed ID: 26971562   DOI: 10.1039/c6bm00011h
12614  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage  J Biochem  2016  159(2):225-37  PubMed ID: 26378248   DOI: 10.1093/jb/mvv098
12629  Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine  Anticancer Res  2016  36(12):6311-6318  PubMed ID: 27919951   DOI: 10.21873/anticanres.11227
12630  Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.  The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo  Oncotarget  2016  7(19):27021-32  PubMed ID: 27027242   DOI: 10.18632/oncotarget.8395
12631  Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J.  Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer  Transl Oncol  2016  9(3):203-10  PubMed ID: 27267838   DOI: 10.1016/j.tranon.2016.03.007
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12948  Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K.  Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2  Cancer Sci  2016  107(9):1321-8  PubMed ID: 27324116   DOI: 10.1111/cas.12995
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853   DOI: 10.1186/s12885-016-2585-6
12974  Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M.  Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation  Part Fibre Toxicol  2016  13:16  PubMed ID: 27026438   DOI: 10.1186/s12989-016-0127-7
13469  Tanabe K.  Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization  Sci Rep  2016  6:25095  PubMed ID: 27117592   DOI: 10.1038/srep25095
13976  Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R.  Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair  Cancer Sci  2016  107(9):1250-5  PubMed ID: 27341700   DOI: 10.1111/cas.12998
13996  Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M.  Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers  Bioconjug Chem  2016  27(10):2307-2314  PubMed ID: 27580353   DOI: 10.1021/acs.bioconjchem.6b00255
14026  Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance  Anticancer Res  2016  36(10):5153-5161  PubMed ID: 27798875   DOI: 10.21873/anticanres.11085
14028  Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.  A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam  PLoS One  2016  11(11):e0166848  PubMed ID: 27875573   DOI: 10.1371/journal.pone.0166848
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14095  Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida  Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells  Nanoscience and Nanotechnology Letters  2016  8:310-315    DOI: 10.1166/nnl.2016.2132
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14286  Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N.  Prognostic significance of MYH9 expression in resected non-small cell lung cancer  PLoS One  2015  10(3):e0121460  PubMed ID: 25826333   DOI: 10.1371/journal.pone.0121460
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14953  Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y.  A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents  Anticancer Res  2015  35(11):5851-5  PubMed ID: 26504007  
15015  Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E.  Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells  Yonago Acta Med  2015  58(1):31-8  PubMed ID: 26190895  
15069  Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T.  Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels  Chem Biodivers  2015  12(4):547-58  PubMed ID: 25879500   DOI: 10.1002/cbdv.201400424
15117  Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A.  Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer  Mol Cancer Ther  2015  14(11):2433-40  PubMed ID: 26351321   DOI: 10.1158/1535-7163.MCT-15-0050
15198  Pauli G, Aepfelbacher M, Bauerfeind U, Blümel J, Burger R, Gärtner B, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Strobel J, Willkommen H, Baylis SA, German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’.  Hepatitis E Virus  Transfus Med Hemother  2015  2(4):247-65.  PubMed ID: 26557817   DOI: 10.1159/000431191
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6014  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H.  Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.  J Gen Virol  2014  95(Pt 10):2166-75  PubMed ID: 24970738   DOI: 10.1099/vir.0.066910-0
10200  Masanori Horie, Keiko Nishio, Haruhisa Kato, Shigehisa Endoh, Katsuhide Fujita, Ayako Nakamura, Shinichi Kinugasa, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi   Evaluation of Cellular Influences Caused by Calcium Carbonate Nanoparticles  Chem Biol Interact .  2014  210:64-76  PubMed ID: 24412303   DOI: 10.1016/j.cbi.2013.12.013
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15845  Kitamura K, Seike M, Okano T, Matsuda K, Miyanaga A, Mizutani H, Noro R, Minegishi Y, Kubota K, Gemma A.  MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells  Mol Cancer Ther  2014  13(2):444-53  PubMed ID: 24258346   DOI: 10.1158/1535-7163.MCT-13-0448
16547  Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, Suzuki T, Koike K, Akihisa R, Akihisa T.  Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities  Chem Biodivers  2014  11(7):987-1000  PubMed ID: 25044585   DOI: 10.1002/cbdv.201400052
16548  Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T.  Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities  Chem Biodivers  2014  11(1):73-84  PubMed ID: 24443427   DOI: 10.1002/cbdv.201300266
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17137  Mamdouh N. Samy, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Mohamed S. Kamel  One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande  Phytochemistry Letters  2014  10:86-90    DOI: 10.1016/j.phytol.2014.08.009
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15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110
16601  Ukiya M, Sawada S, Kikuchi T, Kushi Y, Fukatsu M, Akihisa T.  Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines  Chem Biodivers  2013  10(2):177-88  PubMed ID: 23418165   DOI: 10.1002/cbdv.201200406
18586  Matsuo K, Nakagawa H, Adachi Y, Kameda E, Aizawa K, Tsumoto H, Suzuki T, Miyata N.  Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor  Chem Pharm Bull (Tokyo)  2012  60(8):1055-62  PubMed ID: 22863710   DOI: 10.1248/cpb.c12-00348
18765  Sumitomo T, Nakata M, Yamaguchi M, Terao Y, Kawabata S.  S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells  J Med Microbiol  2012  61(Pt 1):101-108  PubMed ID: 21890513   DOI: 10.1099/jmm.0.033688-0
5376  Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H.  Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.  Eur J Pharm Biopharm  2012  80(2):340-6  PubMed ID: 22036988   DOI: 10.1016/j.ejpb.2011.10.011
5620  Tabata A, Ohkubo Y, Sakakura E, Tomoyasu T, Ohkura K, Nagamune H.  Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool.  Anticancer Res  2012  32(6):2323-9  PubMed ID: 22641669  
6432  Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H.  Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells.  Virus Res  2012  170(1-2):126-37  PubMed ID: 23041252   DOI: 10.1016/j.virusres.2012.09.015
12718  Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.  Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells  Biochim Biophys Acta  2012  1823(6):1110-8  PubMed ID: 22546605   DOI: 10.1016/j.bbamcr.2012.04.005
16032  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H.  A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food  Arch Virol  2012  157(2):235-46.  PubMed ID: 22048607   DOI: 10.1007/s00705-011-1153-2
16490  Shiba-Ishii A, Noguchi M.  Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma  Am J Pathol  2012  180(4):1653-62  PubMed ID: 22310466   DOI: 10.1016/j.ajpath.2011.12.014
16596  Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K.  Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors  Cancer Sci  2012  103(11):1946-54  PubMed ID: 22863020   DOI: 10.1111/j.1349-7006.2012.02408.x
16599  Yamadori T, Ishii Y, Homma S, Morishima Y, Kurishima K, Itoh K, Yamamoto M, Minami Y, Noguchi M, Hizawa N.  Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers  Oncogene  2012  31(45):4768-77  PubMed ID: 22249257   DOI: 10.1038/onc.2011.628
17472  Ashinuma H, Takiguchi Y, Kitazono S, Kitazono-Saitoh M, Kitamura A, Chiba T, Tada Y, Kurosu K, Sakaida E, Sekine I, Tanabe N, Iwama A, Yokosuka O, Tatsumi K.  Antiproliferative action of metformin in human lung cancer cell lines  Oncol Rep  2012  28(1):8-14  PubMed ID: 22576795   DOI: 10.3892/or.2012.1763
7717  Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y.  GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.  Chem. Res. Toxicol.  2011  24:1836-44  PubMed ID: 21827172   DOI: 10.1021/tx200025y
7765  Herlambang S, Kumagai M, Nomoto T, Horie S, Fukushima S, Oba M, Miyazaki K, Morimoto Y, Nishiyama N, Kataoka K.  Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy.  J Control Release  2011  155:449-57  PubMed ID: 21704092   DOI: 10.1016/j.jconrel.2011.06.019
7806  Hoshino A, Ishii G, Ito T, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A.  Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.  Cancer Res.  2011  71:4769-79  PubMed ID: 21610106   DOI: 10.1158/0008-5472.CAN-10-3228
7900  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery.  Chem. Pharm. Bull.  2011  59:298-301  PubMed ID: 21372409   DOI: 10.1248/cpb.59.298
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18332  Motoyama K, Nakashima Y, Aramaki Y, Hirayama F, Uekama K, Arima H.  In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes  J Drug Deliv  2011  2011:476137  PubMed ID: 21490752   DOI: 10.1155/2011/476137
8125  Ishigaki Y, Nakamura Y, Takehara T, Nemoto N, Kurihara T, Koga H, Nakagawa H, Takegami T, Tomosugi N, Miyazawa S, Kuwabata S.  Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis.  Microsc. Res. Tech.  2011  74:415-20  PubMed ID: 20830703   DOI: 10.1002/jemt.20924
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18789  Kikuchi T, Ishii K, Noto T, Takahashi A, Tabata K, Suzuki T, Akihisa T.  Cytotoxic and apoptosis-inducing activities of limonoi  J Nat Prod  2011  74(4):866-70  PubMed ID: 21381696   DOI: 10.1021/np100783k
19003  Horie M, Fukui H, Nishio K, Endoh S, Kato H, Fujita K, Miyauchi A, Nakamura A, Shichiri M, Ishida N, Kinugasa S, Morimoto Y, Niki E, Yoshida Y, Iwahashi H.  Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro  J Occup Health  2011  53(2):64-74  PubMed ID: 21233593   DOI: 10.1539/joh.l10121
19029  Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y.  LRRN4 and UPK3B are markers of primary mesothelial cells  PLoS One  2011  6(10):e25391  PubMed ID: 21984916   DOI: 10.1371/journal.pone.0025391
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202   DOI: 10.5650/jos.60.71
5863  Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y.  The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.  Biomaterials  2011  32(26):6052-8  PubMed ID: 21640378   DOI: 10.1016/j.biomaterials.2011.04.076
6008  Horie M, Kato H, Endoh S, Fujita K, Nishio K, Komaba LK, Fukui H, Nakamura A, Miyauchi A, Nakazato T, Kinugasa S, Yoshida Y, Hagihara Y, Morimoto Y, Iwahashi H.  Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.  Metallomics  2011  3(11):1244-52  PubMed ID: 21804981   DOI: 10.1039/c1mt00060h
9083  Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai  Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis  Infect Immun  2011  79 (11), 4353-60  PubMed ID: 21911469   DOI: 10.1128/IAI.05677-11
12748  Ikari A, Sato T, Takiguchi A, Atomi K, Yamazaki Y, Sugatani J.  Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells  Life Sci  2011  88(13-14):628-33  PubMed ID: 21315735   DOI: 10.1016/j.lfs.2011.02.002
16488  Shiba-Ishii A, Kano J, Morishita Y, Sato Y, Minami Y, Noguchi M.  High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma  Int J Cancer  2011  129(10):2445-53  PubMed ID: 21207417   DOI: 10.1002/ijc.25907
16552  Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N.  ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer  Br J Cancer  2011  104(4):700-6  PubMed ID: 21285982   DOI: 10.1038/sj.bjc.6606012
16553  Hayashi S, Kumai T, Matsuda Y, Aoki N, Sato K, Kimura S, Kitada M, Tateno M, Celis E, Kobayashi H.  Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer  J Transl Med  2011  9:191  PubMed ID: 22053850   DOI: 10.1186/1479-5876-9-191
18333  Horie M, Nishio K, Kato H, Shinohara N, Nakamura A, Fujita K, Kinugasa S, Endoh S, Yamamoto K, Yamamoto O, Niki E, Yoshida Y, Iwahashi H.  In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion  J Biochem  2010  148(3):289-98  PubMed ID: 20576621   DOI: 10.1093/jb/mvq068
8043  Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T.  Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.  J. Pharmacol. Sci.  2010  114:420-32  PubMed ID: 21127389   DOI: 10.1254/jphs.10181fp
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387   DOI: 10.1038/sj.bjc.6605786
8238  Horie M, Nishio K, Fujita K, Kato H, Endoh S, Suzuki M, Nakamura A, Miyauchi A, Kinugasa S, Yamamoto K, Iwahashi H, Murayama H, Niki E, Yoshida Y.  Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.  Toxicol In Vitro  2010  24:1629-38  PubMed ID: 20541599   DOI: 10.1016/j.tiv.2010.06.003
8346  Ishikawa Y, Nagai J, Okada Y, Sato K, Yumoto R, Takano M.  Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.  Biol. Pharm. Bull.  2010  33:504-11  PubMed ID: 20190417   DOI: 10.1248/bpb.33.504
19004  Masanori HORIE, Lilian Kaede KOMABA, Harushisa KATO, Sigehisa ENDOH, Katsuhide FUJITA, Keiko NISHIO, Ayako NAKAMURA, Arisa MIYAUCHI, Shinichi KINUGASA, Yoshihisa HAGIHARA, Yasukazu YOSHIDA, Hitoshi IWAHASHI  In vitro Evaluation of Cellular Responses Induced by Al(OH)3-treated Rutile TiO2 anoparticles  Nano Biomedicine  2010  2:182-193    DOI: 10.11344/nano.2.182
19529  Miyake K, Li F, Tezuka Y, Awale S, Kadota S.  Cytotoxic activity of quassinoids from Eurycoma longifolia  Nat Prod Commun  2010  5(7):1009-12  PubMed ID: 20734929  
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349   DOI: 10.1002/ijc.24865
12266  Kohei Tahara, Hiromitsu Yamamoto, Naohide Hirashima, Yoshiaki Kawashima  Chitosan-modified poly(D,L-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects  Eur J Pharm Biopharm  2010  74(3):421-6  PubMed ID: 20034563   DOI: 10.1016/j.ejpb.2009.12.007
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11378  T. Ohnuma, T. Matsumoto, T. Komats, T. Nishiyama, K. Ogura, H. Iwata, A. Hiratsuka  Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxification of electrophiles and lung cancer chemotherapy.  J Traditional Medicines  2010  27:122-133    DOI: 10.11339/jtm.27.122
13818  Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura  Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene  Journal of Electromagnetic Analysis and Applications  2010  2:382-394    DOI: 10.4236/jemaa.2010.26050
16149  Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A.  Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells  Am J Pathol  2010  176(2):968-80  PubMed ID: 20035059   DOI: 10.2353/ajpath.2010.090299
16518  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines  Nat Prod Commun  2010  5(10):1601-6.  PubMed ID: 21121257  
16551  Song X, Chen Z, Wu C, Zhao S.  Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines  Can J Neurol Sci  2010  37(4):504-11  PubMed ID: 20724260   DOI: 10.1017/s0317167100010544
18295  Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M.  Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer  Clin Cancer Res  2009  15(10):3423-32  PubMed ID: 19417020   DOI: 10.1158/1078-0432.CCR-08-2822
18297  Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I.  Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth  Invest New Drugs  2009  27(2):111-9  PubMed ID: 18551247   DOI: 10.1007/s10637-008-9141-4
18300  Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K.  Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems  Part Fibre Toxicol  2009  6:23  PubMed ID: 19725983   DOI: 10.1186/1743-8977-6-23
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8489  Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T.  Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.  J. Pharmacol. Sci.  2009  111:182-92  PubMed ID: 19783865   DOI: 10.1254/jphs.09201fp
8509  Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S.  Cytotoxic constituents of Soymida febrifuga from Myanmar.  J. Nat. Prod.  2009  72:1631-6  PubMed ID: 19689125   DOI: 10.1021/np9003323
8523  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.  Int J Pharm  2009  382:198-204  PubMed ID: 19646519   DOI: 10.1016/j.ijpharm.2009.07.023
8596  Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y.  The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus.  Pediatr. Res.  2009  66:168-73  PubMed ID: 19390482   DOI: 10.1203/PDR.0b013e3181aa3b2e
8626  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.  Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.  Cancer  2009  115:2580-93  PubMed ID: 19309748   DOI: 10.1002/cncr.24281
8659  Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M.  Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.  Respir. Res.  2009  10:8  PubMed ID: 19192276   DOI: 10.1186/1465-9921-10-8
8688  Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa  Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells  Journal of Health Science  2009  55:845-850    DOI: 10.1248/jhs.55.845
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655   DOI: 10.3945/jn.108.092528
18451  Hannachi Imen E, Nakamura M, Mie M, Kobatake E.  Construction of multifunctional proteins for tissue engineering: epidermal growth factor with collagen binding and cell adhesive activities  J Biotechnol  2009  139(1):19-25  PubMed ID: 18984018   DOI: 10.1016/j.jbiotec.2008.09.011
19002  Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nakano H, Nanashima N, Niki E, Yoshida Y.  Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells  Chem Res Toxicol  2009  22(3):543-53  PubMed ID: 19216582   DOI: 10.1021/tx800289z
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
16646  Matsunami K, Otsuka H, Kondo K, Shinzato T, Kawahata M, Yamaguchi K, Takeda Y.  Absolute configuration of (+)-pinoresinol 4-O-[6''-O-galloyl]-beta-D-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius  Phytochemistry  2009  70(10):1277-85  PubMed ID: 19683319   DOI: 10.1016/j.phytochem.2009.07.020
18311  Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A.  Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter  J Nucl Med  2008  49(4):615-22  PubMed ID: 18344442   DOI: 10.2967/jnumed.107.048231
18334  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T.  Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release  Biosci Biotechnol Biochem  2008  72(9):2481-4  PubMed ID: 18776661   DOI: 10.1271/bbb.80362
13878  Tanaka Y, Goto K, Matsumoto Y, Ueoka R.  Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis  Int J Pharm  2008  359(1-2):264-71  PubMed ID: 18511224   DOI: 10.1016/j.ijpharm.2008.03.045
16645  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship  Bioorg Med Chem  2008  16(10):5434-40  PubMed ID: 18440233   DOI: 10.1016/j.bmc.2008.04.016
17238  Matsuda Y, Yamamoto T, Kudo M, Kawahara K, Kawamoto M, Nakajima Y, Koizumi K, Nakazawa N, Ishiwata T, Naito Z.  Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma  Int J Oncol  2008  33(6):1177-85  PubMed ID: 19020750  
18608  Chen H, Zhang L, Jin Z, Jin E, Fujiwara M, Ghazizadeh M, Asoh S, Ohta S, Kawanami O.  Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats  Exp Mol Pathol  2007  83(3):377-84  PubMed ID: 17959170   DOI: 10.1016/j.yexmp.2007.08.016
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725   DOI: 10.1021/np0604681
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453   DOI: 10.1111/j.1365-2672.2006.03260.x
16537  Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK.  E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers  Clin Cancer Res  2007  13(10):3043-50  PubMed ID: 17505007   DOI: 10.1158/1078-0432.CCR-06-2103
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158
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9054  Naoko Asaoka, Yasuko Tanaka, Tatsuya Sakai, Yutaka Fujii, Reiko Ohuchi, Masanobu Ohuchi  Low Growth Ability of Recent Influenza Clinical Isolates in MDCK Cells Is Due to Their Low Receptor Binding Affinities  Microbes Infect  2006  8 (2), 511-9  PubMed ID: 16300986   DOI: 10.1016/j.micinf.2005.08.006
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