CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0098 : A549]

4609 Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 1976 17(1):62-70 PubMed ID: 175022 DOI: 10.1002/ijc.2910170110

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22418 Bo T, Osaki T, Fujii J. Dephosphorylation of branched-chain α-keto acid dehydrogenase E1α (BCKDHA) promotes branched-chain amino acid catabolism and renders cancer cells resistant to X-rays by mitigating DNA damage. Biochem Biophys Res Commun 2025 742:151154 PubMed ID: 39672007 DOI: 10.1016/j.bbrc.2024.151154

22500 Motoyama M, Shigefuku R, Tanaka N, Nishizawa M, Oshio K, Suhara Y, Yajima I. Acyclic Retinoid Inhibits the EGFR/AKT Signaling Pathway and Cancels Cisplatin-resistant Cell Characteristics. Anticancer Res 2025 45(2):433-443 PubMed ID: 39890166 DOI: 10.21873/anticanres.17432

22532 Toma T, Nakahara R, Otsuka M, Fujita M, Tateishi H. An anti-cell migration compound that binds to hnRNP U and suppresses nuclear deformation. Bioorg Chem 2025 156:108215 PubMed ID: 39899942 DOI: 10.1016/j.bioorg.2025.108215

22537 Ogawa K, Tagami T, Miyake S, Ozeki T. Choice of organic solvent affects function of mRNA-LNP; pyridine produces highly functional mRNA-LNP. Int J Pharm 2025 125367 PubMed ID: 39971169 DOI: 10.1016/j.ijpharm.2025.125367

22549 Eltigani SA, Ohta C, Nakamiya R, Yokono M, Bito T, Takahashi K, Yabuta Y, Eltayeb MM, Ohta T, Ishihara A. Exploring Volatiles and Biological Effects of Commiphora africana and Boswellia papyrifera Incense. Molecules 2025 PubMed ID: 39942603 DOI: 10.3390/molecules30030499

22561 Ishida F, Moriya S, Takahashi D, Toshima K. A novel porphyrin-based theranostic agent activated by cysteine over-expressed in cancer cells shows promise for tumour-targeted monitoring and phototherapy. Bioorg Med Chem 2025 121:118131 PubMed ID: 40024144 DOI: 10.1016/j.bmc.2025.118131

22584 Dziadosz-Brzezińska A, Kusiński S, Piróg A, Urban-Wójciuk Z, Padariya M, Kalathiya U, Kote S, Sznarkowska A. Considerations for antibody-based detection of NRF2 in human cells. Redox Biol 2025 81:103549 PubMed ID: 40043449 DOI: 10.1016/j.redox.2025.103549

22736 Zhao Y, Hisayoshi T, Zhang D, Suzuki S, Watanabe T, Kobayashi A, Guo Q, Momozawa Y, Shimokawa T, Kato S, Miki Y, Sunada S. Steroid-Modulated Transcription Synergistically Forms DNA Double-Strand Breaks With Topoisomerase II Inhibitor. Cancer Sci 2025 PubMed ID: 40231641 DOI: 10.1111/cas.70081

22789 Kamii M, Kamata R, Saito H, Yamamoto G, Mashima C, Yamauchi T, Nakao T, Sakae Y, Yamamori-Morita T, Nakai K, Hakozaki Y, Takenaka M, Okamoto A, Ohashi A. PARP inhibitors elicit a cellular senescence mediated inflammatory response in homologous recombination proficient cancer cells. Sci Rep 2025 15(1):15458 PubMed ID: 40316566 DOI: 10.1038/s41598-025-00336-4

22934 Roldán N, Verdugo M, Suzuki N, Zamora N, Quiroz W, Gonzalez A, Tognarelli J, Ogra Y. Toxicological effects of Sb(III), Sb(V), and NMG-Sb(V) in human lung, kidney, and liver cells: cytotoxicity and fibrotic factor induction. J Toxicol Sci 2025 50(6):283-292 PubMed ID: 40451857 DOI: 10.2131/jts.50.283

22976 Okano K, Aida R, Suwa H, Tanga N, Kishima K, Yalikun Y, Hosokawa Y, Hagiwara H. Gas Microbubble Formation via Near-Infrared Femtosecond Laser Ablation in Live Cells Chembiochem 2025 26(12):e202500086 PubMed ID: 40348583 DOI: 10.1002/cbic.202500086

22977 Masaharu Sakamoto, Seriha Kai, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka, Tanima Biswas, Takashi Sakamoto, Misaki Teshima, Misaki Iwanaga, Akiko Nishikawa, Arisa Sakamoto, Rie Shimozono, Hiroki Kameyama, Masami Nambu, Takuya Masunaga, Kensaku Anraku Oxaprozin and SB-431542 Hybrid Molecule Inhibits Fibrosis and Cancer Cell Migration Synlett 2025 DOI: 10.1055/a-2500-9552

22979 Miyata-Morita K, Kawashima A, Kiriya M, Dejima H, Saito K, Sakao Y, Suzuki K, Sasajima Y, Morita S. Perilipin 2 mediates progression of lung adenocarcinoma by modulating lipid metabolism. Am J Pathol 2025 PubMed ID: 40541711 DOI: 10.1016/j.ajpath.2025.05.016

22983 Hashimoto T, Saito S, Ohata M, Okuwaki M. The oncoprotein DEK controls growth-regulated gene expression by enhancing the DNA-binding activity of basic leucine zipper transcription factors FEBS J 2025 2025 May 2 PubMed ID: 40318137 DOI: 10.1111/febs.70124

22985 Sato K, Ogawa K, Tagami T, Ozeki T. Photothermal therapeutic effect by gold nanostars/extracellular vesicles nanocomplex on melanoma cells J Pharm Sci 2025 114(2):1391-1397 PubMed ID: 39694268 DOI: 10.1016/j.xphs.2024.12.014

22990 Hamabe M, Dewa W, Yuki M, Yamada E, Aiba T, Horikoshi K, Hamakubo T, Ohashi R, Okamoto A. Near-infrared photochemical internalization: design of a distorted zinc phthalocyanine for efficient intracellular delivery of immunotoxins RSC Med Chem 2025 16(6):2615-2626 PubMed ID: 40190421 DOI: 10.1039/d4md00931b

22994 Kobayashi T, Nishiyama T, Yamada K, Murata K, Okamoto H. Plasmid-Based Reverse Genetics System Enabling One-Step Generation of Genotype 3 Hepatitis E Virus Viruses 2025 17(5):669 PubMed ID: 40431681 DOI: 10.3390/v17050669

21542 Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. J Am Chem Soc 2024 PubMed ID: 38170469 DOI: 10.1021/jacs.3c09524

21618 Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. J Biol Chem 2024 300(1):105584 PubMed ID: 38141761 DOI: 10.1016/j.jbc.2023.105584

21652 Yoshida T, Goto K, Kodama A, Bolidong D, Seto T, Hanayama R. Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity. Arch Biochem Biophys 2024 755:109964 PubMed ID: 38527699 DOI: 10.1016/j.abb.2024.109964

21806 Suzuki M, Kobayashi H, Hara D, Hanaoka H. Elimination of radiation-induced senescent cancer cells and stromal cells in vitro by near-infrared photoimmunotherapy. Cancer Med 2024 13(12):e7381 PubMed ID: 38888415 DOI: 10.1002/cam4.7381

21821 Ito T, Tamashiro S, Okuda H, Yamazoe E, Tahara K. Cryomilled electrospun nanofiber mats containing d-mannitol exhibit suitable for aerosol delivery of proteins. Int J Pharm 2024 661:124425 PubMed ID: 38971509 DOI: 10.1016/j.ijpharm.2024.124425

21833 Hata M, Kadoya Y, Ueno J, Taki M, Kodera M. Dicopper Complexes of p-Cresol-2,6-bis(amide-tether-dpa4-X) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups. Inorg Chem 2024 PubMed ID: 39011904 DOI: 10.1021/acs.inorgchem.4c01072

21878 Kimura R, Hashimoto S, Eguchi H, Morikawa Y, Suenami K, Yoshino Y, Matsunaga T, Endo S, Ikari A. Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells. Arch Biochem Biophys 2024 110106 PubMed ID: 39067558 DOI: 10.1016/j.abb.2024.110106

21889 Nii T, Hijii S, Kaneko R, Tanito K, Yamanaka K, Kishimura A, Mori T, Katayama Y. In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme. Anal Sci 2024 40(8):1529-1535 PubMed ID: 38748393 DOI: 10.1007/s44211-024-00593-9

22013 Takahashi K, Tanaka T, Ishihara A, Ohta T. Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity. Discov Oncol 2024 15(1):177 PubMed ID: 38769217 DOI: 10.1007/s12672-024-01041-w

22181 Tomihari M, Iwasaki M, Ishikawa M. Propranolol and landiolol inhibit cell proliferation enhanced by noradrenaline in human lung adenocarcinoma cells. Biomed Res 2024 45(6):253-259 PubMed ID: 39581614 DOI: 10.2220/biomedres.45.253

22182 Pustimbara A, Umami RW, Prakoso NM, Rozaliyani A, Zaini J, Dwiranti A, Ogura SI, Bowolaksono A. Hemin Promotes Higher Effectiveness of Aminolevulinic-Photodynamic Therapy (ALA-PDT) in A549 Lung Cancer Cell Line by Interrupting ABCG2 Expression. Med Sci (Basel) 2024 12(4) PubMed ID: 39584916 DOI: 10.3390/medsci12040066

22273 Primadharsini PP, Takahashi M, Nishizawa T, Sato Y, Nagashima S, Murata K, Okamoto H. The Full-Genome Analysis and Generation of an Infectious cDNA Clone of a Genotype 6 Hepatitis E Virus Variant Obtained from a Japanese Wild Boar: In Vitro Cultivation in Human Cell Lines Viruses 2024 16(6):842 PubMed ID: 38932135 DOI: 10.3390/v16060842

22353 Akai M, Maeda Y, Kawami M, Yumoto R, Takano M, Uchida Y. miR-PAIR: microRNA-protein analysis of integrative relationship for the identification of significantly working miRNAs. Biochim Biophys Acta Gen Subj 2024 1869(2):130746 PubMed ID: 39706375 DOI: 10.1016/j.bbagen.2024.130746

22365 Eguchi H, Yu Y, Yoshino Y, Hara H, Tanaka H, Ikari A. Plasma-activated medium ameliorates the chemoresistance of human lung adenocarcinoma cells mediated via downregulation of claudin-2 expression Arch Biochem Biophys 2024 751:109846 PubMed ID: 38056686 DOI: 10.1016/j.abb.2023.109846

22533 Staining, magnification, and algorithmic conditions for highly accurate cell detection and cell classification by deep learning Staining, magnification, and algorithmic conditions for highly accurate cell detection and cell classification by deep learning Am J Clin Pathol 2024 161(4):399-410 PubMed ID: 38134350 DOI: 10.1093/ajcp/aqad162

22705 Sugimoto M, Sasaki E, Ohno H, Ikeno T, Yamada S, Hanaoka K. Development of a Fluorescence Probe for Detecting Nitroreductase Activity Based on Steric Repulsion-Induced Twisted Intramolecular Charge Transfer (sr-TICT) Chem Pharm Bull (Tokyo) 2024 72(9):810-816 PubMed ID: 39313385 DOI: 10.1248/cpb.c24-00486

22708 Miyazaki H, Chang B, Ogawa M, Shibuya R, Takata M, Nakamura S, Ubukata K, Miyazaki Y, Matsumoto T, Akeda Y. Bacteriological characteristics and changes of Streptococcus pneumoniae serotype 35B after vaccine implementation in Japan Epidemiol Infect 2024 152:e114 PubMed ID: 39363586 DOI: 10.1017/S0950268824001031

22771 Ryosuke Yoshida, Ryosei Kaguma, Ryosuke Kaneko, Ichiro Matuso, Makoto Yoritate, Go Hirai, Takamasa Teramoto, Yoshimitsu Kakuta, Kosuke Minamihata, Noriho Kamiya, Teruki Nii, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama Orthogonality of α-Sulfoquinovosidase in Human Cells and Development of Its Fluorescent Substrate Sensors and Materials 2024 36:3227 DOI: 10.18494/sam4816

22804 Koinuma Y, Mitsuishi Y, Winardi W, Hidayat M, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Hayashi T, Shimada N, Tajima K, Takamochi K, Takahashi F, Suzuki K, Takahashi K. Anti-Müllerian hormone type II receptor protein expression in non-small cell lung cancer and the effect of AMH/AMHR2 signaling on cancer cell proliferation Thorac Cancer 2024 15(29):2090-2099 PubMed ID: 39230026 DOI: 10.1111/1759-7714.15309

17622 Maruyama S, Sakabe N, Ito C, Shimoyama Y, Sato S, Ikeda K. Effect of Specimen Processing Technique on Cell Detection and Classification by Artificial Intelligence Am J Clin Pathol 2023 aqac178 PubMed ID: 36933198 DOI: 10.1093/ajcp/aqac178

17769 Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H. Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone Viruses 2023 15(4):845 PubMed ID: 37112827 DOI: 10.3390/v15040845

17785 Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K. Relationship between a deep learning model and liquid-based cytological processing techniques Cytopathology 2023 Apr 13 PubMed ID: 37051774 DOI: 10.1111/cyt.13235

17792 Ryo Doge, Yuki Nishino, Akiko Saito Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria BioChem 2023 3:61-77 DOI: 10.3390/biochem3020005

17808 Sato Y, Yoshino H, Sato K, Kashiwakura I, Tsuruga E. DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines J Radiat Res 2023 rrad016 PubMed ID: 37023702 DOI: 10.1093/jrr/rrad016

17814 Tamai M, Taba S, Mise T, Yamashita M, Ishikawa H, Shintake T. Ethanol vapor inhalation treatment inhibits lethal respiratory viral infection with Influenza A J Infect Dis 2023 jiad089 PubMed ID: 37101418 DOI: 10.1093/infdis/jiad089

17816 Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters EJNMMI Research 2023 13 PubMed ID: 37115356 DOI: 10.1186/s13550-023-00988-1

19547 Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Ishibashi S, Kawashima-Sonoyama Y, Matsuzaki Y, Taketani T. Extracellular Vesicles and Cx43-Gap Junction Channels Are the Main Routes for Mitochondrial Transfer from Ultra-Purified Mesenchymal Stem Cells, RECs Int J Mol Sci 2023 24(12):10294 PubMed ID: 37373439 DOI: 10.3390/ijms241210294

19548 Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade Nat Commun 2023 14(1):7490 PubMed ID: 37980406 DOI: 10.1038/s41467-023-43274-3

19549 Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses Proc Natl Acad Sci U S A 2023 120(42):e2304139120 PubMed ID: 37831739 DOI: 10.1073/pnas.2304139120

19550 Oka N, Shimada K, Ishii A, Kobayashi N, Kondo K. SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production iScience 2023 26(6):106954 PubMed ID: 37275532 DOI: 10.1016/j.isci.2023.106954

19554 Amma C, Inomata Y, Kohno R, Satake M, Furukawa A, Nagata Y, Sugiyama H, Seto T, Suzuki R. Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells Environ Geochem Health 2023 45(8):5879-5891 PubMed ID: 37179508 DOI: 10.1007/s10653-023-01599-4

19555 Kobayashi A, Hiroyama Y, Mamiya T, Oikawa M, Konishi T. The COX-2/PGE2 Response Pathway Upregulates Radioresistance in A549 Human Lung Cancer Cells through Radiation-Induced Bystander Signaling Biology (Basel) 2023 12(11):1368 PubMed ID: 37997966 DOI: 10.3390/biology12111368

19605 Zhang D, Shimokawa T, Guo Q, Dan S, Miki Y, Sunada S. Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break Cancer Sci 2023 114(3):1108-1117. PubMed ID: 36385507 DOI: 10.1111/cas.15659

19918 Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I. Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation Toxicol Mech Methods 2023 33(9):741-754 PubMed ID: 37496379 DOI: 10.1080/15376516.2023.2238061

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

19976 Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer J Med Chem 2023 Dec 17 PubMed ID: 38105611 DOI: 10.1021/acs.jmedchem.3c01493

21065 Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A. Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly. J Am Chem Soc 2023 145(1):135-142 PubMed ID: 36538570 DOI: 10.1021/jacs.2c08974

21080 Miura K, Koyanagi-Aoi M, Maniwa Y, Aoi T. Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis. Cancer Cell Int 2023 23(1):34 PubMed ID: 36841751 DOI: 10.1186/s12935-023-02870-5

21168 Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T. Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer. Stem Cell Res Ther 2023 14(1):40 PubMed ID: 36927781 DOI: 10.1186/s13287-023-03274-y

21185 Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S. Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives. Drug Deliv 2023 30(1):2191891 PubMed ID: 36964673 DOI: 10.1080/10717544.2023.2191891

21259 Takata J, Kiura K, Nakasuka T, Hirabae A, Arimoto-Kobayashi S. Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice. Genes Environ 2023 45(1):19 PubMed ID: 37280663 DOI: 10.1186/s41021-023-00276-3

21379 Hata M, Ueno J, Hitomi Y, Kodera M. Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates. ACS Omega 2023 8(31):28690-28701 PubMed ID: 37576680 DOI: 10.1021/acsomega.3c03387

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21514 Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat Commun 2023 14(1):8095 PubMed ID: 38092728 DOI: 10.1038/s41467-023-43630-3

21516 Wang H, Zhang H, Tamura R, Da B, Abdellatef SA, Watanabe I, Ishida N, Fujita D, Hanagata N, Nakagawa T, Nakanishi J. Mapping stress inside living cells by atomic force microscopy in response to environmental stimuli. Sci Technol Adv Mater 2023 24(1):2265434 PubMed ID: 37867575 DOI: 10.1080/14686996.2023.2265434

21526 Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. Eur J Pharmacol 2023 960:176156 PubMed ID: 38059445 DOI: 10.1016/j.ejphar.2023.176156

21547 Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T. Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions. Biology (Basel) 2023 12(12) PubMed ID: 38132311 DOI: 10.3390/biology12121485

22275 Jin G, Ma M, Yang C, Zhen L, Feng M. Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624-mediated PD-L1 pathway Thorac Cancer 2023 14(24):2493-2503 PubMed ID: 37423604 DOI: 10.1111/1759-7714.15034

17494 Maeda A, Fujimura T, Hirakawa N, Baba K, Kawamoto S. A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells Biol Pharm Bull 2022 45(10):1581-1584 PubMed ID: 35979561 DOI: 10.1248/bpb.b22-00310

17595 Maki M, JeongMin H, Nakagawa T, Kawai H, Sakamoto N, Sato Y, Noguchi M. Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome Pathol Int 2022 72(10):496-505 PubMed ID: 35920378 DOI: 10.1111/pin.13262

17647 Tamari S, Menju T, Toyazaki T, Miyamoto H, Chiba N, Noguchi M, Ishikawa H, Miyata R, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Ohsumi A, Hamaji M, Date H. Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer Oncol Rep 2022 48(4):171 PubMed ID: 35959810 DOI: 10.3892/or.2022.8386

18224 Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S. Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53 Chem Res Toxicol 2022 35(9):1598-1603 PubMed ID: 36027604 DOI: 10.1021/acs.chemrestox.2c00202

13435 Funato N, Yanagisawa H. TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties Sci Rep 2022 12(1):20188 PubMed ID: 36418889 DOI: 10.1038/s41598-022-24604-9

20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20391 Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H. Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs. J Biosci Bioeng 2022 PubMed ID: 34789413 DOI: 10.1016/j.jbiosc.2021.10.001

20408 Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K. Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology. Acta Cytol 2022 1-6 PubMed ID: 34644702 DOI: 10.1159/000519335

20410 Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T. Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells. Radiat Res 2022 PubMed ID: 34634126 DOI: 10.1667/RADE-21-00112.1

20486 Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y. Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells. Oncol Rep 2022 47(2) PubMed ID: 34935060 DOI: 10.3892/or.2021.8243

16353 Tsujiya Y, Hasegawa A, Yamamori M, Okamura N. Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines Biol Pharm Bull 2022 45(3):276-283 PubMed ID: 35228393 DOI: 10.1248/bpb.b21-00785

20590 Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T. High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells. Molecules 2022 27(4) PubMed ID: 35209077 DOI: 10.3390/molecules27041287

20595 Matsushige T, Sakabe T, Umekita Y. Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line. Yonago Acta Med 2022 65(1):44-52 PubMed ID: 35221759 DOI: 10.33160/yam.2022.02.006

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20657 Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y. Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure. Biochem Biophys Rep 2022 29:101223 PubMed ID: 35146136 DOI: 10.1016/j.bbrep.2022.101223

20674 Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y. The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets. Cell Rep 2022 39(4):110721 PubMed ID: 35476996 DOI: 10.1016/j.celrep.2022.110721

20684 Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O. Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis. Transl Oncol 2022 21:101431 PubMed ID: 35452996 DOI: 10.1016/j.tranon.2022.101431

16485 Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M. Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration Int J Mol Sci 2022 23(9):5047 PubMed ID: 35563439 DOI: 10.3390/ijms23095047

16496 Siswanto FM, Tamura A, Sakuma R, Imaoka S. Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway Mol Pharmacol 2022 101(4):257-273 PubMed ID: 35193967 DOI: 10.1124/molpharm.121.000475

16710 Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka A vitamin D C/D ring-derived compound with cytotoxicity Medicinal Chemistry Research 2022 1120-1125 DOI: 10.1007/s00044-021-02842-2

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20808 Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity Chemical and Pharmaceutical Bulletin 2022 477-482 PubMed ID: 35786566 DOI: 10.1248/cpb.c21-01087

16959 Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells Medicinal Chemistry Research 2022 31:1584-1593 DOI: 10.1007/s00044-022-02939-2

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20896 Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K. Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network. Acta Cytol 2022 1-9 PubMed ID: 36067744 DOI: 10.1159/000526098

20912 Kotani N, Nakano T, Kuwahara R. Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis. J Biol Chem 2022 298(11):102500 PubMed ID: 36152751 DOI: 10.1016/j.jbc.2022.102500

20963 Takata J, Miyake N, Saiki Y, Tada M, Sasaki K, Kubo T, Kiura K, Arimoto-Kobayashi S. Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse. Genes Environ 2022 44(1):26 PubMed ID: 36494703 DOI: 10.1186/s41021-022-00255-0

22969 Sumire Arai, Khulan Bidbayasakh, Atsushi Fukuda, Kazunori Takashima, Hirofumi Kurita Oxidative modification in nuclear and mitochondrial DNA and its removal in A549 human lung cancer cells exposed to cold atmospheric-pressure plasma Japanese Journal of Applied Physics 2022 61:096003 DOI: 10.35848/1347-4065/ac8536

12851 Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M. Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M Bioorg Chem 2021 107:104627 PubMed ID: 33476868 DOI: 10.1016/j.bioorg.2021.104627

13332 Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K. Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer. Oncol Rep 2021 PubMed ID: 33155667 DOI: 10.3892/or.2020.7839

13432 Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka K, Hayat F, Karim M, Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities Nat Commun 2021 12(1):6767 PubMed ID: 34799586 DOI: 10.1038/s41467-021-27080-3

20016 Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T. Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Sci Rep 2021 11(1):1492 PubMed ID: 33452347 DOI: 10.1038/s41598-021-81077-y

20076 Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K. Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. Biochem Biophys Rep 2021 26:100946 PubMed ID: 33644423 DOI: 10.1016/j.bbrep.2021.100946

13718 Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H. miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells Mol Biol Rep 2021 Mar 6 PubMed ID: 33675467 DOI: 10.1007/s11033-021-06255-7

13912 Yamamoto S, Nakanishi J. Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle Anal Sci 2021 37(5):741-745 PubMed ID: 33390415 DOI: 10.2116/analsci.20SCP16

20145 Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R. Screening for inhibitory effects of crude drugs on furin-like enzymatic activities. J Nat Med 2021 PubMed ID: 33928494 DOI: 10.1007/s11418-021-01519-9

20147 Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol 2021 4(1):490 PubMed ID: 33883697 DOI: 10.1038/s42003-021-02003-6

14339 Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection mBio 2021 e0326920 PubMed ID: 34061598 DOI: 10.1128/mBio.03269-20

20205 Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K. Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. Food Chem Toxicol 2021 154:112319 PubMed ID: 34087405 DOI: 10.1016/j.fct.2021.112319

20278 Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A. Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein. Eur J Med Chem 2021 215:113288 PubMed ID: 33640763 DOI: 10.1016/j.ejmech.2021.113288

15273 Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T. Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse Prostaglandins Other Lipid Mediat 2021 Jul 9 PubMed ID: 34252545 DOI: 10.1016/j.prostaglandins.2021.106580

15490 Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H. LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence Transl Oncol 2021 14(11):101212 PubMed ID: 34461558 DOI: 10.1016/j.tranon.2021.101212

15504 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency Nat Commun 2021 12(1):5041 PubMed ID: 34413299 DOI: 10.1038/s41467-021-25249-4

20362 Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H. Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells. Biochem Biophys Res Commun 2021 577:146-151 PubMed ID: 34517212 DOI: 10.1016/j.bbrc.2021.09.015

20363 Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C. Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin. Anticancer Res 2021 41(9):4321-4331 PubMed ID: 34475052 DOI: 10.21873/anticanres.15237

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

20423 Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T. Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells. Histochem Cell Biol 2021 155(6):637-653 PubMed ID: 33974136 DOI: 10.1007/s00418-021-01966-1

15879 Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K. 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2 iScience 2021 24(10):103120 PubMed ID: 34541466 DOI: 10.1016/j.isci.2021.103120

15881 Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Nat Commun 2021 12(1):6602 PubMed ID: 34782627 DOI: 10.1038/s41467-021-26910-8

20510 Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N. Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device. Toxics 2021 9(12) PubMed ID: 34941765 DOI: 10.3390/toxics9120331

16119 Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y. Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation Pathol Int 2021 71(1):15-23 PubMed ID: 33112501 DOI: 10.1111/pin.13040

16128 Sato Y, Yoshino H, Kashiwakura I, Tsuruga E. DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells Int J Mol Sci 2021 22(1):420 PubMed ID: 33401559 DOI: 10.3390/ijms22010420

16219 Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma Cancer Sci 2021 112(12):5114-5126 PubMed ID: 34628698 DOI: 10.1111/cas.15160

16225 M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells Folia Biol (Praha) 2021 67(2):62-69. PubMed ID: 34624938

16231 Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A. Upregulation of Chemoresistance by Mg 2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells Cells 2021 10(5):1179 PubMed ID: 34066059 DOI: 10.3390/cells10051179

16523 Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis Particle & Particle Systems Characterization 2021 38:2100003 DOI: 10.1002/ppsc.202100003

17827 Hirofumi Kurita, Yoshie Minamijima, Kazunori Takashima Characterization of intracellular reactive species production stimulated by cold atmospheric pressure plasma irradiation Int. J. Plasma Environ. Sci. Technol 2020 14:e03003 (9pp) DOI: 10.34343/ijpest.2020.14.e03003

6923 Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A. Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochim Biophys Acta Mol Cell Res. 2020 1867(4):118642 PubMed ID: 31923533 DOI: 10.1016/j.bbamcr.2019.118642

9729 Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts Exp Cell Res 2020 391(2):112010 PubMed ID: 32305327 DOI: 10.1016/j.yexcr.2020.112010

9819 Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis Biosci Biotechnol Biochem 2020 84(4):757-763 PubMed ID: 31868102 DOI: 10.1080/09168451.2019.1706442

11986 Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K. Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus. J. Radiat. Res. 2020 61(2):237-242. PubMed ID: 31904079 DOI: 10.1093/jrr/rrz098

12065 Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T. Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells. Biochim Biophys Acta Mol Cell Biol Lipids 2020 PubMed ID: 32112978 DOI: 10.1016/j.bbalip.2020.158675

12375 Morita S, Horii T, Kimura M, Hatada I. Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform Int J Mol Sci 2020 21(5):1574 PubMed ID: 32106616 DOI: 10.3390/ijms21051574

12376 Uddin M, Kawami M, Yumoto R, Takano M. Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells Naunyn Schmiedebergs Arch Pharmacol 2020 393(5):889-896 PubMed ID: 31900520 DOI: 10.1007/s00210-019-01802-3

12607 Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair Oncol Res 2020 28(2):161-175 PubMed ID: 31727206 DOI: 10.3727/096504019X15736439848765

12989 Endo M, Ohba K, Sato S, Yokota Y, Takahashi K. Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells 2020 PubMed ID: 32314441 DOI: 10.1111/gtc.12776

12990 Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A. Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression. Nutrients 2020 PubMed ID: 32340376 DOI: 10.3390/nu12041190

12998 Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H. Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds. Appl Radiat Isot 2020 PubMed ID: 32561042 DOI: 10.1016/j.apradiso.2020.109201

13002 Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K. Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway. Respir Investig 2020 PubMed ID: 32359980 DOI: 10.1016/j.resinv.2020.01.003

13021 Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K. Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation. PLoS One 2020 PubMed ID: 32374749 DOI: 10.1371/journal.pone.0232724

13089 Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y. Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions. Sci Rep 2020 PubMed ID: 32612147 DOI: 10.1038/s41598-020-67488-3

13167 Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N. Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy. Biochem Biophys Res Commun 2020 PubMed ID: 32828300 DOI: 10.1016/j.bbrc.2020.07.082

13228 Togami K, Maruta Y, Nanbu M, Tada H, Chono S. Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis. Drug Dev Ind Pharm 2020 PubMed ID: 32940095 DOI: 10.1080/03639045.2020.1825473

13260 Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y. Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis. Immun Inflamm Dis 2020 PubMed ID: 33016012 DOI: 10.1002/iid3.355

13295 Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y. Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells. Oncol Lett 2020 PubMed ID: 33133262 DOI: 10.3892/ol.2020.12226

13342 Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N. Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity. Nanomaterials (Basel) 2020 PubMed ID: 33202926 DOI: 10.3390/nano10112250

13523 Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549 bioRxiv 2020 October 0４ DOI: 10.1101/2020.10.02.323881

13535 RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells DNA Repair (Amst) 2020 91-92:102872 PubMed ID: 32502756 DOI: 10.1016/j.dnarep.2020.102872

13568 Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI) Authorea Preprints 2020 DOI: 10.22541/au.158316431.10469346

13622 Sato Y, Yoshino H, Tsuruga E, Kashiwakura I. Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation Curr Cancer Drug Targets 2020 20(5):372-381 PubMed ID: 31951181 DOI: 10.2174/1568009620666200115161717

13767 Togami K, Yamaguchi K, Tada H, Chono S. Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis Pharmazie 2020 75(8):371-374 PubMed ID: 32758335 DOI: 10.1691/ph.2020.0048

13841 Eguchi R, Wakabayashi I. HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer Oncol Rep 2020 44(1):14-28 PubMed ID: 32319650 DOI: 10.3892/or.2020.7580

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14836 Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library Cell Chem Biol 2020 27(6):708-718.e1 PubMed ID: 32402240 DOI: 10.1016/j.chembiol.2020.04.007

14849 Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H. The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD Free Radic Res 2020 54(11-12):829-840 PubMed ID: 31809610 DOI: 10.1080/10715762.2019.1696965

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11360 Futami K, Kimoto M, Lim YWS, Hirao I. Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells. Mol Ther Nucleic Acids 2019 PubMed ID: 30594072 DOI: 10.1016/j.omtn.2018.11.011

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4061 Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T. BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION. Radiat Prot Dosimetry 2019 PubMed ID: 30535060 DOI: 10.1093/rpd/ncy249

4759 Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity Molecules 2019 24:3535 PubMed ID: 31574910 DOI: 10.3390/molecules24193535

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11675 Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging CHEMNANOMAT 2019 DOI: 10.1002/cnma.201900289

11808 Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M. Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer. Anticancer Res. 2019 PubMed ID: 31519584 DOI: 10.21873/anticanres.13667

11848 Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M. Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. Cancers (Basel) 2019 PubMed ID: 31614999 DOI: 10.3390/cancers11101550

11864 Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K. Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1. J. Org. Chem. 2019 PubMed ID: 31642324 DOI: 10.1021/acs.joc.9b02304

9758 Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line Oncol Lett 2019 17(2):2431-2440 PubMed ID: 30719114 DOI: 10.3892/ol.2018.9869

10357 Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors Eur J Med Chem 2019 82:111648 PubMed ID: 31493743 DOI: 10.1016/j.ejmech.2019.111648

12378 Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development Oncogene 2019 38(14):2580-2594 PubMed ID: 30531840 DOI: 10.1038/s41388-018-0603-7

12379 Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M. Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis Clin Cancer Res 2019 25(9):2809-2820 PubMed ID: 30728155 DOI: 10.1158/1078-0432.CCR-18-3631

12380 Chinnathambi S, Hanagata N. Photostability of quantum dot micelles under ultraviolet irradiation Luminescence 2019 34(5):472-479 PubMed ID: 30809921 DOI: 10.1002/bio.3618

12381 Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI. Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake Photodiagnosis Photodyn Ther 2019 27:327-335 PubMed ID: 31252141 DOI: 10.1016/j.pdpdt.2019.06.017

12382 Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F. Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma Cancer Sci 2019 110(2):726-733 PubMed ID: 30499156 DOI: 10.1111/cas.13895

9502 Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell 2018 33:355-367.e7 PubMed ID: 29533781 DOI: 10.1016/j.ccell.2018.02.004

10702 Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y. Mechanism of recipient cell-dependent differences in exosome uptake. BMC Cancer 2018 18:47 PubMed ID: 29306323 DOI: 10.1186/s12885-017-3958-1

10803 Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M. Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions. Lab Chip 2018 18:1378-1387 PubMed ID: 29658964 DOI: 10.1039/c7lc01280b

10805 Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H. Effects of cationic liposomes with stearylamine against virus infection. Int J Pharm 2018 543:311-317 PubMed ID: 29625169 DOI: 10.1016/j.ijpharm.2018.04.001

11049 Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection. J Infect Dis 2018 217(11):1740-1749 PubMed ID: 29529215 DOI: 10.1093/infdis/jiy081

11076 Toyama K, Nomura W, Kobayakawa T, Tamamura H. Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjug. Chem. 2018 29(6):2050-2057 PubMed ID: 29763296 DOI: 10.1021/acs.bioconjchem.8b00250

11177 Kobayashi A, Konishi T. Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells. J. Radiat. Res. 2018 59(6):754-759 PubMed ID: 30124879 DOI: 10.1093/jrr/rry065

11164 Mogi K, Hayashida K, Yamamoto T. Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel. Anal Sci 2018 34(8):875-880 PubMed ID: 30101880 DOI: 10.2116/analsci.17P462

4072 Takayuki Hirono et al MiR-301a/b function as oncomiRs in non-small-cell lung cancer Integr Mol Med 2018 5: 1-6 DOI: 10.15761/IMM.1000347

4097 Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H. Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay. Virus Res 2018 243:69-74 PubMed ID: 29074234 DOI: 10.1016/j.virusres.2017.10.015

4132 Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology 2018 PubMed ID: 28756527 DOI: 10.1007/s10616-017-0124-1

4133 Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K. Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung 2018 PubMed ID: 29926178 DOI: 10.1007/s00408-018-0134-6

4134 Sato Y, Yoshino H, Kazama Y, Kashiwakura I. Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer. Mol Med Rep 2018 PubMed ID: 30320341 DOI: 10.3892/mmr.2018.9536

4135 Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y. CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30448176 DOI: 10.1016/j.bbrc.2018.11.055

4136 Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S. Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells. Tohoku J. Exp. Med. 2018 PubMed ID: 29459573 DOI: 10.1620/tjem.244.133

4137 Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H. In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran. Int. J. Biol. Macromol. 2018 PubMed ID: 28964842 DOI: 10.1016/j.ijbiomac.2017.09.085

4138 Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O. Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30446226 DOI: 10.1016/j.bbrc.2018.11.035

4139 Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M. High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma. Pathol. Int. 2018 PubMed ID: 30320419 DOI: 10.1111/pin.12724

4141 Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C. Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells. Oncotarget 2018 PubMed ID: 30220973 DOI: 10.18632/oncotarget.25994

4468 Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y. A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells. Medchemcomm 2018 9(5):783-788 PubMed ID: 30108967 DOI: 10.1039/c8md00010g

7050 Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I. Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma. Oncotarget 2017 8:2890-2905 PubMed ID: 27926516 DOI: 10.18632/oncotarget.13761

10274 Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M. Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark. Chem. Biodivers. 2017 14: PubMed ID: 28425165 DOI: 10.1002/cbdv.201700105

10280 Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A. AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier. Oncol. Rep. 2017 37:3261-3269 PubMed ID: 28440492 DOI: 10.3892/or.2017.5594

10381 Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T. Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling. Mutat. Res. 2017 803-805:1-8 PubMed ID: 28689138 DOI: 10.1016/j.mrfmmm.2017.06.006

10924 Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin RSC Adv 2017 7, 2392-2402 DOI: 10.1039/C6RA26592H

4526 Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017 818, 7-16 PubMed ID: 28477879 DOI: 10.1016/j.mrgentox.2017.04.002

9171 Haruhiko Fuwa, Mizuho Sato A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells Mar Drugs 2017 15 (10) PubMed ID: 29053565 DOI: 10.3390/md15100320

10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

12213 Cancer Lett Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells 2017 390:160-167 PubMed ID: 28093283 DOI: 10.1016/j.canlet.2017.01.006

12218 Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis J Pharmacol Toxicol Methods 2017 86:19-27. PubMed ID: 28259823 DOI: 10.1016/j.vascn.2017.02.023

14030 El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M. Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2 Biomed Pharmacother 2017 85:549-555 PubMed ID: 27889230 DOI: 10.1016/j.biopha.2016.11.063

14081 Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models Allergy 2017 72(7):1043-1053. PubMed ID: 27878831 DOI: 10.1111/all.13079

14432 Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M. miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma Cancer Sci 2017 108(3):536-542 PubMed ID: 28012229 DOI: 10.1111/cas.13148

14529 Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R. Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells Radiat Res 2017 188(5):591-594 PubMed ID: 28829673 DOI: 10.1667/RR14824.1

14665 Takahashi K, Ohta T. Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells Biochem Biophys Res Commun 2017 490(3):587-593 PubMed ID: 28629997 DOI: 10.1016/j.bbrc.2017.06.082

14674 Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y. Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy J Am Chem Soc 2017 139(39):13713-13719 PubMed ID: 28872304 DOI: 10.1021/jacs.7b05019

14730 Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T. Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells Sci Rep 2017 7(1):12317. PubMed ID: 28951614 DOI: 10.1038/s41598-017-12017-y

16608 Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C. Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents Anticancer Res 2017 37(11):6177-6188 PubMed ID: 29061799 DOI: 10.21873/anticanres.12067

7063 Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I. Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. Nat. Biotechnol. 2016 34:1060-1065 PubMed ID: 27571369 DOI: 10.1038/nbt.3658

7193 Yamazoe H, Hagihara Y, Kobayashi H. Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs. Tissue Eng Part C Methods 2016 22:20-9 PubMed ID: 26421875 DOI: 10.1089/ten.TEC.2015.0188

9581 Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta 2016 1863:1170-8 PubMed ID: 26919807 DOI: 10.1016/j.bbamcr.2016.02.015

9774 Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H. Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone. Virus Res. 2016 223:170-80 PubMed ID: 27485920 DOI: 10.1016/j.virusres.2016.07.011

9884 Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C. Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin. Anticancer Res. 2016 36:6083-6092 PubMed ID: 27793936 DOI: 10.21873/anticanres.11198

19389 Ohue Y, Kurose K, Nozawa R, Isobe M, Nishio Y, Tanaka T, Doki Y, Hori T, Fukuoka J, Oka M, Nakayama E. Survival of Lung Adenocarcinoma Patients Predicted from Expression of PD-L1, Galectin-9, and XAGE1 (GAGED2a) on Tumor Cells and Tumor-Infiltrating T Cells Cancer Immunol Res 2016 4(12):1049-1060 PubMed ID: 27799141 DOI: 10.1158/2326-6066.CIR-15-0266

9117 Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis PLoS One 2016 11 (1), e0147957 PubMed ID: 26807591 DOI: 10.1371/journal.pone.0147957

10117 Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy Biomater Sci . 2016 4(5):826-38 PubMed ID: 26971562 DOI: 10.1039/c6bm00011h

12614 Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M. Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage J Biochem 2016 159(2):225-37 PubMed ID: 26378248 DOI: 10.1093/jb/mvv098

12629 Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C. Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine Anticancer Res 2016 36(12):6311-6318 PubMed ID: 27919951 DOI: 10.21873/anticanres.11227

12630 Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C. The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo Oncotarget 2016 7(19):27021-32 PubMed ID: 27027242 DOI: 10.18632/oncotarget.8395

12631 Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J. Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer Transl Oncol 2016 9(3):203-10 PubMed ID: 27267838 DOI: 10.1016/j.tranon.2016.03.007

12646 Husni RE, Shiba-Ishii A, Iiyama S, Shiozawa T, Kim Y, Nakagawa T, Sato T, Kano J, Minami Y, Noguchi M. DNMT3a expression pattern and its prognostic value in lung adenocarcinoma Lung Cancer 2016 97:59-65 PubMed ID: 27237029 DOI: 10.1016/j.lungcan.2016.04.018

12681 Toyama K, Mizuguchi T, Nomura W, Tamamura H. Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization Bioorg Med Chem 2016 24(16):3406-12 PubMed ID: 27283787 DOI: 10.1016/j.bmc.2016.05.026

12948 Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K. Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2 Cancer Sci 2016 107(9):1321-8 PubMed ID: 27324116 DOI: 10.1111/cas.12995

12949 Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I. p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines BMC Cancer 2016 16:521 PubMed ID: 27456853 DOI: 10.1186/s12885-016-2585-6

12974 Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation Part Fibre Toxicol 2016 13:16 PubMed ID: 27026438 DOI: 10.1186/s12989-016-0127-7

13469 Tanabe K. Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization Sci Rep 2016 6:25095 PubMed ID: 27117592 DOI: 10.1038/srep25095

13976 Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair Cancer Sci 2016 107(9):1250-5 PubMed ID: 27341700 DOI: 10.1111/cas.12998

13996 Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M. Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers Bioconjug Chem 2016 27(10):2307-2314 PubMed ID: 27580353 DOI: 10.1021/acs.bioconjchem.6b00255

14026 Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C. Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance Anticancer Res 2016 36(10):5153-5161 PubMed ID: 27798875 DOI: 10.21873/anticanres.11085

14028 Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H. A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam PLoS One 2016 11(11):e0166848 PubMed ID: 27875573 DOI: 10.1371/journal.pone.0166848

14041 Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T. Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark Chem Biodivers 2016 13(11):1601-1609 PubMed ID: 27492128 DOI: 10.1002/cbdv.201600247

14095 Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells Nanoscience and Nanotechnology Letters 2016 8:310-315 DOI: 10.1166/nnl.2016.2132

17169 Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y. Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae) J Nat Med 2016 70(2):241-52 PubMed ID: 26825781 DOI: 10.1007/s11418-016-0967-3

5653 Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H. Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems. Anticancer Res 2015 35(8):4411-7 PubMed ID: 26168480

14286 Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N. Prognostic significance of MYH9 expression in resected non-small cell lung cancer PLoS One 2015 10(3):e0121460 PubMed ID: 25826333 DOI: 10.1371/journal.pone.0121460

14460 Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I. Effects of X‑ray irradiation in combination with ascorbic acid on tumor control Mol Med Rep 2015 12(4):5449-54 PubMed ID: 26238154 DOI: 10.3892/mmr.2015.4108

14953 Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y. A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents Anticancer Res 2015 35(11):5851-5 PubMed ID: 26504007

15015 Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E. Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells Yonago Acta Med 2015 58(1):31-8 PubMed ID: 26190895

15069 Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T. Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels Chem Biodivers 2015 12(4):547-58 PubMed ID: 25879500 DOI: 10.1002/cbdv.201400424

15117 Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A. Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer Mol Cancer Ther 2015 14(11):2433-40 PubMed ID: 26351321 DOI: 10.1158/1535-7163.MCT-15-0050

15198 Pauli G, Aepfelbacher M, Bauerfeind U, Blümel J, Burger R, Gärtner B, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Strobel J, Willkommen H, Baylis SA, German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’. Hepatitis E Virus Transfus Med Hemother 2015 2(4):247-65. PubMed ID: 26557817 DOI: 10.1159/000431191

15455 Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M. In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells Metallomics 2015 7(5):816-27 PubMed ID: 25781390 DOI: 10.1039/c5mt00031a

5612 Yamada A, Aki T, Unuma K, Funakoshi T, Uemura K. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells PLoS One 2015 10(3):e0120192 PubMed ID: 25799450 DOI: 10.1371/journal.pone.0120192

17443 Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T. An on-chip small intestine-liver model for pharmacokinetic studies J Lab Autom 2015 20(3):265-73 PubMed ID: 25385717 DOI: 10.1177/2211068214557812

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