CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0098 : A549]

4609 Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 1976 17(1):62-70 PubMed ID: 175022 DOI: 10.1002/ijc.2910170110

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21542 Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. J Am Chem Soc 2024 PubMed ID: 38170469 DOI: 10.1021/jacs.3c09524

21618 Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. J Biol Chem 2024 300(1):105584 PubMed ID: 38141761 DOI: 10.1016/j.jbc.2023.105584

21652 Yoshida T, Goto K, Kodama A, Bolidong D, Seto T, Hanayama R. Extracellular vesicles promote silica nanoparticle aggregation that inhibits silica-induced cytotoxicity. Arch Biochem Biophys 2024 755:109964 PubMed ID: 38527699 DOI: 10.1016/j.abb.2024.109964

21806 Suzuki M, Kobayashi H, Hara D, Hanaoka H. Elimination of radiation-induced senescent cancer cells and stromal cells in vitro by near-infrared photoimmunotherapy. Cancer Med 2024 13(12):e7381 PubMed ID: 38888415 DOI: 10.1002/cam4.7381

21821 Ito T, Tamashiro S, Okuda H, Yamazoe E, Tahara K. Cryomilled electrospun nanofiber mats containing d-mannitol exhibit suitable for aerosol delivery of proteins. Int J Pharm 2024 661:124425 PubMed ID: 38971509 DOI: 10.1016/j.ijpharm.2024.124425

21833 Hata M, Kadoya Y, Ueno J, Taki M, Kodera M. Dicopper Complexes of p-Cresol-2,6-bis(amide-tether-dpa4-X) (X = MeO and Cl): Selective ROS Generation and Cytotoxicity Enhancement Controlled by Electronic and Hydrophobic Effects of the MeO and Cl Groups. Inorg Chem 2024 PubMed ID: 39011904 DOI: 10.1021/acs.inorgchem.4c01072

21878 Kimura R, Hashimoto S, Eguchi H, Morikawa Y, Suenami K, Yoshino Y, Matsunaga T, Endo S, Ikari A. Enhancement of chemoresistance by claudin-1-mediated formation of amino acid barriers in human lung adenocarcinoma A549 cells. Arch Biochem Biophys 2024 110106 PubMed ID: 39067558 DOI: 10.1016/j.abb.2024.110106

21889 Nii T, Hijii S, Kaneko R, Tanito K, Yamanaka K, Kishimura A, Mori T, Katayama Y. In vitro evaluation of novel SN-38 prodrug activated by α-rhamnosidase of exogenous enzyme. Anal Sci 2024 40(8):1529-1535 PubMed ID: 38748393 DOI: 10.1007/s44211-024-00593-9

22013 Takahashi K, Tanaka T, Ishihara A, Ohta T. Strobilurin X acts as an anticancer drug by inhibiting protein synthesis and suppressing mitochondrial respiratory chain activity. Discov Oncol 2024 15(1):177 PubMed ID: 38769217 DOI: 10.1007/s12672-024-01041-w

17622 Maruyama S, Sakabe N, Ito C, Shimoyama Y, Sato S, Ikeda K. Effect of Specimen Processing Technique on Cell Detection and Classification by Artificial Intelligence Am J Clin Pathol 2023 aqac178 PubMed ID: 36933198 DOI: 10.1093/ajcp/aqac178

17769 Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H. Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone Viruses 2023 15(4):845 PubMed ID: 37112827 DOI: 10.3390/v15040845

17785 Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K. Relationship between a deep learning model and liquid-based cytological processing techniques Cytopathology 2023 Apr 13 PubMed ID: 37051774 DOI: 10.1111/cyt.13235

17792 Ryo Doge, Yuki Nishino, Akiko Saito Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria BioChem 2023 3:61-77 DOI: 10.3390/biochem3020005

17808 Sato Y, Yoshino H, Sato K, Kashiwakura I, Tsuruga E. DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines J Radiat Res 2023 rrad016 PubMed ID: 37023702 DOI: 10.1093/jrr/rrad016

17814 Tamai M, Taba S, Mise T, Yamashita M, Ishikawa H, Shintake T. Ethanol vapor inhalation treatment inhibits lethal respiratory viral infection with Influenza A J Infect Dis 2023 jiad089 PubMed ID: 37101418 DOI: 10.1093/infdis/jiad089

17816 Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters EJNMMI Research 2023 13 DOI: 10.1186/s13550-023-00988-1

19547 Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Ishibashi S, Kawashima-Sonoyama Y, Matsuzaki Y, Taketani T. Extracellular Vesicles and Cx43-Gap Junction Channels Are the Main Routes for Mitochondrial Transfer from Ultra-Purified Mesenchymal Stem Cells, RECs Int J Mol Sci 2023 24(12):10294 PubMed ID: 37373439 DOI: 10.3390/ijms241210294

19548 Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade Nat Commun 2023 14(1):7490 PubMed ID: 37980406 DOI: 10.1038/s41467-023-43274-3

19549 Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses Proc Natl Acad Sci U S A 2023 120(42):e2304139120 PubMed ID: 37831739 DOI: 10.1073/pnas.2304139120

19550 Oka N, Shimada K, Ishii A, Kobayashi N, Kondo K. SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production iScience 2023 26(6):106954 PubMed ID: 37275532 DOI: 10.1016/j.isci.2023.106954

19554 Amma C, Inomata Y, Kohno R, Satake M, Furukawa A, Nagata Y, Sugiyama H, Seto T, Suzuki R. Copper in airborne fine particulate matter (PM2.5) from urban sites causes the upregulation of pro-inflammatory cytokine IL-8 in human lung epithelial A549 cells Environ Geochem Health 2023 45(8):5879-5891 PubMed ID: 37179508 DOI: 10.1007/s10653-023-01599-4

19555 Kobayashi A, Hiroyama Y, Mamiya T, Oikawa M, Konishi T. The COX-2/PGE2 Response Pathway Upregulates Radioresistance in A549 Human Lung Cancer Cells through Radiation-Induced Bystander Signaling Biology (Basel) 2023 12(11):1368 PubMed ID: 37997966 DOI: 10.3390/biology12111368

19605 Zhang D, Shimokawa T, Guo Q, Dan S, Miki Y, Sunada S. Discovery of novel DNA-damaging agents through phenotypic screening for DNA double-strand break Cancer Sci 2023 114(3):1108-1117. PubMed ID: 36385507 DOI: 10.1111/cas.15659

19918 Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I. Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation Toxicol Mech Methods 2023 33(9):741-754 PubMed ID: 37496379 DOI: 10.1080/15376516.2023.2238061

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

19976 Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer J Med Chem 2023 Dec 17 PubMed ID: 38105611 DOI: 10.1021/acs.jmedchem.3c01493

21065 Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A. Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly. J Am Chem Soc 2023 145(1):135-142 PubMed ID: 36538570 DOI: 10.1021/jacs.2c08974

21080 Miura K, Koyanagi-Aoi M, Maniwa Y, Aoi T. Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis. Cancer Cell Int 2023 23(1):34 PubMed ID: 36841751 DOI: 10.1186/s12935-023-02870-5

21168 Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T. Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer. Stem Cell Res Ther 2023 14(1):40 PubMed ID: 36927781 DOI: 10.1186/s13287-023-03274-y

21185 Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S. Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives. Drug Deliv 2023 30(1):2191891 PubMed ID: 36964673 DOI: 10.1080/10717544.2023.2191891

21259 Takata J, Kiura K, Nakasuka T, Hirabae A, Arimoto-Kobayashi S. Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice. Genes Environ 2023 45(1):19 PubMed ID: 37280663 DOI: 10.1186/s41021-023-00276-3

21379 Hata M, Ueno J, Hitomi Y, Kodera M. Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates. ACS Omega 2023 8(31):28690-28701 PubMed ID: 37576680 DOI: 10.1021/acsomega.3c03387

21380 Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I. Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia. Anticancer Res 2023 43(8):3429-3439 PubMed ID: 37500171 DOI: 10.21873/anticanres.16518

21514 Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat Commun 2023 14(1):8095 PubMed ID: 38092728 DOI: 10.1038/s41467-023-43630-3

21526 Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. Eur J Pharmacol 2023 960:176156 PubMed ID: 38059445 DOI: 10.1016/j.ejphar.2023.176156

21547 Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T. Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions. Biology (Basel) 2023 12(12) PubMed ID: 38132311 DOI: 10.3390/biology12121485

17494 Maeda A, Fujimura T, Hirakawa N, Baba K, Kawamoto S. A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells Biol Pharm Bull 2022 45(10):1581-1584 PubMed ID: 35979561 DOI: 10.1248/bpb.b22-00310

17595 Maki M, JeongMin H, Nakagawa T, Kawai H, Sakamoto N, Sato Y, Noguchi M. Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome Pathol Int 2022 72(10):496-505 PubMed ID: 35920378 DOI: 10.1111/pin.13262

17647 Tamari S, Menju T, Toyazaki T, Miyamoto H, Chiba N, Noguchi M, Ishikawa H, Miyata R, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Ohsumi A, Hamaji M, Date H. Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer Oncol Rep 2022 48(4):171 PubMed ID: 35959810 DOI: 10.3892/or.2022.8386

18224 Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S. Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53 Chem Res Toxicol 2022 35(9):1598-1603 PubMed ID: 36027604 DOI: 10.1021/acs.chemrestox.2c00202

13435 Funato N, Yanagisawa H. TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties Sci Rep 2022 12(1):20188 PubMed ID: 36418889 DOI: 10.1038/s41598-022-24604-9

20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20391 Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H. Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs. J Biosci Bioeng 2022 PubMed ID: 34789413 DOI: 10.1016/j.jbiosc.2021.10.001

20408 Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K. Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology. Acta Cytol 2022 1-6 PubMed ID: 34644702 DOI: 10.1159/000519335

20410 Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T. Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells. Radiat Res 2022 PubMed ID: 34634126 DOI: 10.1667/RADE-21-00112.1

20486 Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y. Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells. Oncol Rep 2022 47(2) PubMed ID: 34935060 DOI: 10.3892/or.2021.8243

16353 Tsujiya Y, Hasegawa A, Yamamori M, Okamura N. Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines Biol Pharm Bull 2022 45(3):276-283 PubMed ID: 35228393 DOI: 10.1248/bpb.b21-00785

20590 Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T. High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells. Molecules 2022 27(4) PubMed ID: 35209077 DOI: 10.3390/molecules27041287

20595 Matsushige T, Sakabe T, Umekita Y. Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line. Yonago Acta Med 2022 65(1):44-52 PubMed ID: 35221759 DOI: 10.33160/yam.2022.02.006

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20657 Fukumoto Y, Matsuhashi K, Tanaka YK, Suzuki N, Ogra Y. Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure. Biochem Biophys Rep 2022 29:101223 PubMed ID: 35146136 DOI: 10.1016/j.bbrep.2022.101223

20674 Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y. The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets. Cell Rep 2022 39(4):110721 PubMed ID: 35476996 DOI: 10.1016/j.celrep.2022.110721

20684 Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O. Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis. Transl Oncol 2022 21:101431 PubMed ID: 35452996 DOI: 10.1016/j.tranon.2022.101431

16485 Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M. Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration Int J Mol Sci 2022 23(9):5047 PubMed ID: 35563439 DOI: 10.3390/ijms23095047

16496 Siswanto FM, Tamura A, Sakuma R, Imaoka S. Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway Mol Pharmacol 2022 101(4):257-273 PubMed ID: 35193967 DOI: 10.1124/molpharm.121.000475

16710 Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka A vitamin D C/D ring-derived compound with cytotoxicity Medicinal Chemistry Research 2022 1120-1125 DOI: 10.1007/s00044-021-02842-2

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20808 Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity Chemical and Pharmaceutical Bulletin 2022 477-482 PubMed ID: 35786566 DOI: 10.1248/cpb.c21-01087

16959 Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells Medicinal Chemistry Research 2022 31:1584-1593 DOI: 10.1007/s00044-022-02939-2

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20896 Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K. Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network. Acta Cytol 2022 1-9 PubMed ID: 36067744 DOI: 10.1159/000526098

20912 Kotani N, Nakano T, Kuwahara R. Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis. J Biol Chem 2022 298(11):102500 PubMed ID: 36152751 DOI: 10.1016/j.jbc.2022.102500

20963 Takata J, Miyake N, Saiki Y, Tada M, Sasaki K, Kubo T, Kiura K, Arimoto-Kobayashi S. Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse. Genes Environ 2022 44(1):26 PubMed ID: 36494703 DOI: 10.1186/s41021-022-00255-0

12851 Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M. Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M Bioorg Chem 2021 107:104627 PubMed ID: 33476868 DOI: 10.1016/j.bioorg.2021.104627

13332 Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K. Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer. Oncol Rep 2021 PubMed ID: 33155667 DOI: 10.3892/or.2020.7839

20016 Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T. Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Sci Rep 2021 11(1):1492 PubMed ID: 33452347 DOI: 10.1038/s41598-021-81077-y

20076 Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K. Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. Biochem Biophys Rep 2021 26:100946 PubMed ID: 33644423 DOI: 10.1016/j.bbrep.2021.100946

13718 Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H. miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells Mol Biol Rep 2021 Mar 6 PubMed ID: 33675467 DOI: 10.1007/s11033-021-06255-7

13912 Yamamoto S, Nakanishi J. Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle Anal Sci 2021 37(5):741-745 PubMed ID: 33390415 DOI: 10.2116/analsci.20SCP16

20145 Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R. Screening for inhibitory effects of crude drugs on furin-like enzymatic activities. J Nat Med 2021 PubMed ID: 33928494 DOI: 10.1007/s11418-021-01519-9

20147 Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol 2021 4(1):490 PubMed ID: 33883697 DOI: 10.1038/s42003-021-02003-6

14339 Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection mBio 2021 e0326920 PubMed ID: 34061598 DOI: 10.1128/mBio.03269-20

20205 Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K. Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. Food Chem Toxicol 2021 154:112319 PubMed ID: 34087405 DOI: 10.1016/j.fct.2021.112319

20278 Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A. Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein. Eur J Med Chem 2021 215:113288 PubMed ID: 33640763 DOI: 10.1016/j.ejmech.2021.113288

15273 Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T. Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse Prostaglandins Other Lipid Mediat 2021 Jul 9 PubMed ID: 34252545 DOI: 10.1016/j.prostaglandins.2021.106580

15490 Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H. LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence Transl Oncol 2021 14(11):101212 PubMed ID: 34461558 DOI: 10.1016/j.tranon.2021.101212

15504 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency Nat Commun 2021 12(1):5041 PubMed ID: 34413299 DOI: 10.1038/s41467-021-25249-4

20362 Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H. Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells. Biochem Biophys Res Commun 2021 577:146-151 PubMed ID: 34517212 DOI: 10.1016/j.bbrc.2021.09.015

20363 Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C. Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin. Anticancer Res 2021 41(9):4321-4331 PubMed ID: 34475052 DOI: 10.21873/anticanres.15237

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

20423 Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T. Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells. Histochem Cell Biol 2021 155(6):637-653 PubMed ID: 33974136 DOI: 10.1007/s00418-021-01966-1

15879 Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K. 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2 iScience 2021 24(10):103120 PubMed ID: 34541466 DOI: 10.1016/j.isci.2021.103120

15881 Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Nat Commun 2021 12(1):6602 PubMed ID: 34782627 DOI: 10.1038/s41467-021-26910-8

20510 Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N. Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device. Toxics 2021 9(12) PubMed ID: 34941765 DOI: 10.3390/toxics9120331

16119 Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y. Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation Pathol Int 2021 71(1):15-23 PubMed ID: 33112501 DOI: 10.1111/pin.13040

16128 Sato Y, Yoshino H, Kashiwakura I, Tsuruga E. DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells Int J Mol Sci 2021 22(1):420 PubMed ID: 33401559 DOI: 10.3390/ijms22010420

16219 Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma Cancer Sci 2021 112(12):5114-5126 PubMed ID: 34628698 DOI: 10.1111/cas.15160

16225 M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells Folia Biol (Praha) 2021 67(2):62-69. PubMed ID: 34624938

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16523 Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis Particle & Particle Systems Characterization 2021 38:2100003 DOI: 10.1002/ppsc.202100003

17827 Hirofumi Kurita, Yoshie Minamijima, Kazunori Takashima Characterization of intracellular reactive species production stimulated by cold atmospheric pressure plasma irradiation Int. J. Plasma Environ. Sci. Technol 2020 14:e03003 (9pp) DOI: 10.34343/ijpest.2020.14.e03003

6923 Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A. Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochim Biophys Acta Mol Cell Res. 2020 1867(4):118642 PubMed ID: 31923533 DOI: 10.1016/j.bbamcr.2019.118642

9729 Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts Exp Cell Res 2020 391(2):112010 PubMed ID: 32305327 DOI: 10.1016/j.yexcr.2020.112010

9819 Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis Biosci Biotechnol Biochem 2020 84(4):757-763 PubMed ID: 31868102 DOI: 10.1080/09168451.2019.1706442

11986 Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K. Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus. J. Radiat. Res. 2020 61(2):237-242. PubMed ID: 31904079 DOI: 10.1093/jrr/rrz098

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12375 Morita S, Horii T, Kimura M, Hatada I. Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform Int J Mol Sci 2020 21(5):1574 PubMed ID: 32106616 DOI: 10.3390/ijms21051574

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12607 Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair Oncol Res 2020 28(2):161-175 PubMed ID: 31727206 DOI: 10.3727/096504019X15736439848765

12989 Endo M, Ohba K, Sato S, Yokota Y, Takahashi K. Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells 2020 PubMed ID: 32314441 DOI: 10.1111/gtc.12776

12990 Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A. Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression. Nutrients 2020 PubMed ID: 32340376 DOI: 10.3390/nu12041190

12998 Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H. Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds. Appl Radiat Isot 2020 PubMed ID: 32561042 DOI: 10.1016/j.apradiso.2020.109201

13002 Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K. Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway. Respir Investig 2020 PubMed ID: 32359980 DOI: 10.1016/j.resinv.2020.01.003

13021 Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K. Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation. PLoS One 2020 PubMed ID: 32374749 DOI: 10.1371/journal.pone.0232724

13089 Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y. Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions. Sci Rep 2020 PubMed ID: 32612147 DOI: 10.1038/s41598-020-67488-3

13167 Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N. Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy. Biochem Biophys Res Commun 2020 PubMed ID: 32828300 DOI: 10.1016/j.bbrc.2020.07.082

13228 Togami K, Maruta Y, Nanbu M, Tada H, Chono S. Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis. Drug Dev Ind Pharm 2020 PubMed ID: 32940095 DOI: 10.1080/03639045.2020.1825473

13260 Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y. Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis. Immun Inflamm Dis 2020 PubMed ID: 33016012 DOI: 10.1002/iid3.355

13295 Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y. Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells. Oncol Lett 2020 PubMed ID: 33133262 DOI: 10.3892/ol.2020.12226

13342 Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N. Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity. Nanomaterials (Basel) 2020 PubMed ID: 33202926 DOI: 10.3390/nano10112250

13523 Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549 bioRxiv 2020 October 0４ DOI: 10.1101/2020.10.02.323881

13535 RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells DNA Repair (Amst) 2020 91-92:102872 PubMed ID: 32502756 DOI: 10.1016/j.dnarep.2020.102872

13568 Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI) Authorea Preprints 2020 DOI: 10.22541/au.158316431.10469346

13622 Sato Y, Yoshino H, Tsuruga E, Kashiwakura I. Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation Curr Cancer Drug Targets 2020 20(5):372-381 PubMed ID: 31951181 DOI: 10.2174/1568009620666200115161717

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13841 Eguchi R, Wakabayashi I. HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer Oncol Rep 2020 44(1):14-28 PubMed ID: 32319650 DOI: 10.3892/or.2020.7580

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14836 Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library Cell Chem Biol 2020 27(6):708-718.e1 PubMed ID: 32402240 DOI: 10.1016/j.chembiol.2020.04.007

14849 Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H. The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD Free Radic Res 2020 54(11-12):829-840 PubMed ID: 31809610 DOI: 10.1080/10715762.2019.1696965

22039 Shinha K, Nihei W, Ono T, Nakazato R, Kimura H. A pharmacokinetic-pharmacodynamic model based on multi-organ-on-a-chip for drug-drug interaction studies. Biomicrofluidics 2020 PubMed ID: 34992705 DOI: 10.1063/5.0011545

11360 Futami K, Kimoto M, Lim YWS, Hirao I. Genetic Alphabet Expansion Provides Versatile Specificities and Activities of Unnatural-Base DNA Aptamers Targeting Cancer Cells. Mol Ther Nucleic Acids 2019 PubMed ID: 30594072 DOI: 10.1016/j.omtn.2018.11.011

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4061 Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T. BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION. Radiat Prot Dosimetry 2019 PubMed ID: 30535060 DOI: 10.1093/rpd/ncy249

4759 Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity Molecules 2019 24:3535 PubMed ID: 31574910 DOI: 10.3390/molecules24193535

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11612 Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A. Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve. Genes Cells 2019 PubMed ID: 31234244 DOI: 10.1111/gtc.12712

11634 Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavichb A, Konishic T. Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation. Radiat. Res. 2019 PubMed ID: 30526323 DOI: 10.1667/RR15155.1

11675 Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging CHEMNANOMAT 2019 DOI: 10.1002/cnma.201900289

11808 Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M. Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer. Anticancer Res. 2019 PubMed ID: 31519584 DOI: 10.21873/anticanres.13667

11848 Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M. Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. Cancers (Basel) 2019 PubMed ID: 31614999 DOI: 10.3390/cancers11101550

11864 Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K. Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1. J. Org. Chem. 2019 PubMed ID: 31642324 DOI: 10.1021/acs.joc.9b02304

9758 Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line Oncol Lett 2019 17(2):2431-2440 PubMed ID: 30719114 DOI: 10.3892/ol.2018.9869

10357 Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors Eur J Med Chem 2019 82:111648 PubMed ID: 31493743 DOI: 10.1016/j.ejmech.2019.111648

12378 Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development Oncogene 2019 38(14):2580-2594 PubMed ID: 30531840 DOI: 10.1038/s41388-018-0603-7

12379 Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M. Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis Clin Cancer Res 2019 25(9):2809-2820 PubMed ID: 30728155 DOI: 10.1158/1078-0432.CCR-18-3631

12380 Chinnathambi S, Hanagata N. Photostability of quantum dot micelles under ultraviolet irradiation Luminescence 2019 34(5):472-479 PubMed ID: 30809921 DOI: 10.1002/bio.3618

12381 Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI. Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake Photodiagnosis Photodyn Ther 2019 27:327-335 PubMed ID: 31252141 DOI: 10.1016/j.pdpdt.2019.06.017

12382 Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F. Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma Cancer Sci 2019 110(2):726-733 PubMed ID: 30499156 DOI: 10.1111/cas.13895

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10803 Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M. Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions. Lab Chip 2018 18:1378-1387 PubMed ID: 29658964 DOI: 10.1039/c7lc01280b

10805 Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H. Effects of cationic liposomes with stearylamine against virus infection. Int J Pharm 2018 543:311-317 PubMed ID: 29625169 DOI: 10.1016/j.ijpharm.2018.04.001

11049 Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection. J Infect Dis 2018 217(11):1740-1749 PubMed ID: 29529215 DOI: 10.1093/infdis/jiy081

11076 Toyama K, Nomura W, Kobayakawa T, Tamamura H. Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjug. Chem. 2018 29(6):2050-2057 PubMed ID: 29763296 DOI: 10.1021/acs.bioconjchem.8b00250

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11164 Mogi K, Hayashida K, Yamamoto T. Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel. Anal Sci 2018 34(8):875-880 PubMed ID: 30101880 DOI: 10.2116/analsci.17P462

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4132 Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology 2018 PubMed ID: 28756527 DOI: 10.1007/s10616-017-0124-1

4133 Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K. Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung 2018 PubMed ID: 29926178 DOI: 10.1007/s00408-018-0134-6

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4135 Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y. CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30448176 DOI: 10.1016/j.bbrc.2018.11.055

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10924 Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin RSC Adv 2017 7, 2392-2402 DOI: 10.1039/C6RA26592H

4526 Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017 818, 7-16 PubMed ID: 28477879 DOI: 10.1016/j.mrgentox.2017.04.002

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10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

12213 Cancer Lett Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells 2017 390:160-167 PubMed ID: 28093283 DOI: 10.1016/j.canlet.2017.01.006

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9884 Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C. Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin. Anticancer Res. 2016 36:6083-6092 PubMed ID: 27793936 DOI: 10.21873/anticanres.11198

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12630 Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C. The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo Oncotarget 2016 7(19):27021-32 PubMed ID: 27027242 DOI: 10.18632/oncotarget.8395

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14028 Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H. A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam PLoS One 2016 11(11):e0166848 PubMed ID: 27875573 DOI: 10.1371/journal.pone.0166848

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17210 Tsutomu Tsuruoka, Davaapurev Bekh-Ochir, Fumio Kato, Shatar Sanduin, Altantsetseg Shataryn, Amarjargal Ayurzana, Tadaaki Satou, Wei Li, Kazuo Koike The essential oil of MongolianNepeta sibirica: a single component and its biological activities Journal of Essential Oil Research 2012 24:555-559 DOI: 10.1080/10412905.2012.729925

17472 Ashinuma H, Takiguchi Y, Kitazono S, Kitazono-Saitoh M, Kitamura A, Chiba T, Tada Y, Kurosu K, Sakaida E, Sekine I, Tanabe N, Iwama A, Yokosuka O, Tatsumi K. Antiproliferative action of metformin in human lung cancer cell lines Oncol Rep 2012 28(1):8-14 PubMed ID: 22576795 DOI: 10.3892/or.2012.1763

7717 Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y. GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate. Chem. Res. Toxicol. 2011 24:1836-44 PubMed ID: 21827172 DOI: 10.1021/tx200025y

7765 Herlambang S, Kumagai M, Nomoto T, Horie S, Fukushima S, Oba M, Miyazaki K, Morimoto Y, Nishiyama N, Kataoka K. Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy. J Control Release 2011 155:449-57 PubMed ID: 21704092 DOI: 10.1016/j.jconrel.2011.06.019

7806 Hoshino A, Ishii G, Ito T, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A. Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression. Cancer Res. 2011 71:4769-79 PubMed ID: 21610106 DOI: 10.1158/0008-5472.CAN-10-3228

7900 Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y. Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery. Chem. Pharm. Bull. 2011 59:298-301 PubMed ID: 21372409 DOI: 10.1248/cpb.59.298

7951 Okamoto H. Hepatitis E virus cell culture models. Virus Res. 2011 161:65-77 PubMed ID: 21316402 DOI: 10.1016/j.virusres.2011.01.015

18332 Motoyama K, Nakashima Y, Aramaki Y, Hirayama F, Uekama K, Arima H. In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes J Drug Deliv 2011 2011:476137 PubMed ID: 21490752 DOI: 10.1155/2011/476137

8125 Ishigaki Y, Nakamura Y, Takehara T, Nemoto N, Kurihara T, Koga H, Nakagawa H, Takegami T, Tomosugi N, Miyazawa S, Kuwabata S. Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis. Microsc. Res. Tech. 2011 74:415-20 PubMed ID: 20830703 DOI: 10.1002/jemt.20924

8176 Haruki T, Shomori K, Hamamoto Y, Taniguchi Y, Nakamura H, Ito H. Geminin expression in small lung adenocarcinomas: implication of prognostic significance. Lung Cancer 2011 71:356-62 PubMed ID: 20650542 DOI: 10.1016/j.lungcan.2010.06.013

18789 Kikuchi T, Ishii K, Noto T, Takahashi A, Tabata K, Suzuki T, Akihisa T. Cytotoxic and apoptosis-inducing activities of limonoi J Nat Prod 2011 74(4):866-70 PubMed ID: 21381696 DOI: 10.1021/np100783k

19003 Horie M, Fukui H, Nishio K, Endoh S, Kato H, Fujita K, Miyauchi A, Nakamura A, Shichiri M, Ishida N, Kinugasa S, Morimoto Y, Niki E, Yoshida Y, Iwahashi H. Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro J Occup Health 2011 53(2):64-74 PubMed ID: 21233593 DOI: 10.1539/joh.l10121

19029 Kanamori-Katayama M, Kaiho A, Ishizu Y, Okamura-Oho Y, Hino O, Abe M, Kishimoto T, Sekihara H, Nakamura Y, Suzuki H, Forrest AR, Hayashizaki Y. LRRN4 and UPK3B are markers of primary mesothelial cells PLoS One 2011 6(10):e25391 PubMed ID: 21984916 DOI: 10.1371/journal.pone.0025391

5322 Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T. 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells. J Oleo Sci 2011 60(2):71-7 PubMed ID: 21263202 DOI: 10.5650/jos.60.71

5863 Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y. The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation. Biomaterials 2011 32(26):6052-8 PubMed ID: 21640378 DOI: 10.1016/j.biomaterials.2011.04.076

6008 Horie M, Kato H, Endoh S, Fujita K, Nishio K, Komaba LK, Fukui H, Nakamura A, Miyauchi A, Nakazato T, Kinugasa S, Yoshida Y, Hagihara Y, Morimoto Y, Iwahashi H. Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion. Metallomics 2011 3(11):1244-52 PubMed ID: 21804981 DOI: 10.1039/c1mt00060h

9083 Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis Infect Immun 2011 79 (11), 4353-60 PubMed ID: 21911469 DOI: 10.1128/IAI.05677-11

12748 Ikari A, Sato T, Takiguchi A, Atomi K, Yamazaki Y, Sugatani J. Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells Life Sci 2011 88(13-14):628-33 PubMed ID: 21315735 DOI: 10.1016/j.lfs.2011.02.002

16488 Shiba-Ishii A, Kano J, Morishita Y, Sato Y, Minami Y, Noguchi M. High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma Int J Cancer 2011 129(10):2445-53 PubMed ID: 21207417 DOI: 10.1002/ijc.25907

16552 Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N. ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer Br J Cancer 2011 104(4):700-6 PubMed ID: 21285982 DOI: 10.1038/sj.bjc.6606012

16553 Hayashi S, Kumai T, Matsuda Y, Aoki N, Sato K, Kimura S, Kitada M, Tateno M, Celis E, Kobayashi H. Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer J Transl Med 2011 9:191 PubMed ID: 22053850 DOI: 10.1186/1479-5876-9-191

18333 Horie M, Nishio K, Kato H, Shinohara N, Nakamura A, Fujita K, Kinugasa S, Endoh S, Yamamoto K, Yamamoto O, Niki E, Yoshida Y, Iwahashi H. In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion J Biochem 2010 148(3):289-98 PubMed ID: 20576621 DOI: 10.1093/jb/mvq068

8043 Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T. Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway. J. Pharmacol. Sci. 2010 114:420-32 PubMed ID: 21127389 DOI: 10.1254/jphs.10181fp

8186 Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y. Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion. Br. J. Cancer 2010 103:517-23 PubMed ID: 20628387 DOI: 10.1038/sj.bjc.6605786

8238 Horie M, Nishio K, Fujita K, Kato H, Endoh S, Suzuki M, Nakamura A, Miyauchi A, Kinugasa S, Yamamoto K, Iwahashi H, Murayama H, Niki E, Yoshida Y. Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less. Toxicol In Vitro 2010 24:1629-38 PubMed ID: 20541599 DOI: 10.1016/j.tiv.2010.06.003

8346 Ishikawa Y, Nagai J, Okada Y, Sato K, Yumoto R, Takano M. Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells. Biol. Pharm. Bull. 2010 33:504-11 PubMed ID: 20190417 DOI: 10.1248/bpb.33.504

19004 Masanori HORIE, Lilian Kaede KOMABA, Harushisa KATO, Sigehisa ENDOH, Katsuhide FUJITA, Keiko NISHIO, Ayako NAKAMURA, Arisa MIYAUCHI, Shinichi KINUGASA, Yoshihisa HAGIHARA, Yasukazu YOSHIDA, Hitoshi IWAHASHI In vitro Evaluation of Cellular Responses Induced by Al(OH)3-treated Rutile TiO2 anoparticles Nano Biomedicine 2010 2:182-193 DOI: 10.11344/nano.2.182

19529 Miyake K, Li F, Tezuka Y, Awale S, Kadota S. Cytotoxic activity of quassinoids from Eurycoma longifolia Nat Prod Commun 2010 5(7):1009-12 PubMed ID: 20734929

5870 Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H. Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth. Int J Cancer. 2010 126(7):1611-20 PubMed ID: 19711349 DOI: 10.1002/ijc.24865

12266 Kohei Tahara, Hiromitsu Yamamoto, Naohide Hirashima, Yoshiaki Kawashima Chitosan-modified poly(D,L-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects Eur J Pharm Biopharm 2010 74(3):421-6 PubMed ID: 20034563 DOI: 10.1016/j.ejpb.2009.12.007

6124 Nguyen Bich Thu　et al Screening of Vietnamese medicinal plants for cytotoxic activity Natural Product Sciences 2010 16(1)

11378 T. Ohnuma, T. Matsumoto, T. Komats, T. Nishiyama, K. Ogura, H. Iwata, A. Hiratsuka Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxiﬁcation of electrophiles and lung cancer chemotherapy. J Traditional Medicines 2010 27:122-133 DOI: 10.11339/jtm.27.122

13818 Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene Journal of Electromagnetic Analysis and Applications 2010 2:382-394 DOI: 10.4236/jemaa.2010.26050

16149 Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A. Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells Am J Pathol 2010 176(2):968-80 PubMed ID: 20035059 DOI: 10.2353/ajpath.2010.090299

16518 Li F, Awale S, Tezuka Y, Kadota S. Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines Nat Prod Commun 2010 5(10):1601-6. PubMed ID: 21121257

16551 Song X, Chen Z, Wu C, Zhao S. Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines Can J Neurol Sci 2010 37(4):504-11 PubMed ID: 20724260 DOI: 10.1017/s0317167100010544

18295 Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M. Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer Clin Cancer Res 2009 15(10):3423-32 PubMed ID: 19417020 DOI: 10.1158/1078-0432.CCR-08-2822

18297 Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I. Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth Invest New Drugs 2009 27(2):111-9 PubMed ID: 18551247 DOI: 10.1007/s10637-008-9141-4

18300 Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K. Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems Part Fibre Toxicol 2009 6:23 PubMed ID: 19725983 DOI: 10.1186/1743-8977-6-23

8436 Li F, Awale S, Tezuka Y, Kadota S. Cytotoxic constituents of propolis from Myanmar and their structure-activity relationship. Biol. Pharm. Bull. 2009 32:2075-8 PubMed ID: 19952433 DOI: 10.1248/bpb.32.2075

8489 Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T. Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf. J. Pharmacol. Sci. 2009 111:182-92 PubMed ID: 19783865 DOI: 10.1254/jphs.09201fp

8509 Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S. Cytotoxic constituents of Soymida febrifuga from Myanmar. J. Nat. Prod. 2009 72:1631-6 PubMed ID: 19689125 DOI: 10.1021/np9003323

8523 Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y. Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells. Int J Pharm 2009 382:198-204 PubMed ID: 19646519 DOI: 10.1016/j.ijpharm.2009.07.023

8596 Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y. The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus. Pediatr. Res. 2009 66:168-73 PubMed ID: 19390482 DOI: 10.1203/PDR.0b013e3181aa3b2e

8626 Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R. Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer. Cancer 2009 115:2580-93 PubMed ID: 19309748 DOI: 10.1002/cncr.24281

8659 Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M. Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells. Respir. Res. 2009 10:8 PubMed ID: 19192276 DOI: 10.1186/1465-9921-10-8

8688 Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells Journal of Health Science 2009 55:845-850 DOI: 10.1248/jhs.55.845

8698 Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A. Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice. J. Nutr. 2009 139:69-75 PubMed ID: 19056655 DOI: 10.3945/jn.108.092528

18451 Hannachi Imen E, Nakamura M, Mie M, Kobatake E. Construction of multifunctional proteins for tissue engineering: epidermal growth factor with collagen binding and cell adhesive activities J Biotechnol 2009 139(1):19-25 PubMed ID: 18984018 DOI: 10.1016/j.jbiotec.2008.09.011

19002 Horie M, Nishio K, Fujita K, Endoh S, Miyauchi A, Saito Y, Iwahashi H, Yamamoto K, Murayama H, Nakano H, Nanashima N, Niki E, Yoshida Y. Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells Chem Res Toxicol 2009 22(3):543-53 PubMed ID: 19216582 DOI: 10.1021/tx800289z

5877 Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. Biol Pharm Bull 2009 32(7):1148-54 PubMed ID: 19571376 DOI: 10.1248/bpb.32.1148

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

16646 Matsunami K, Otsuka H, Kondo K, Shinzato T, Kawahata M, Yamaguchi K, Takeda Y. Absolute configuration of (+)-pinoresinol 4-O-[6''-O-galloyl]-beta-D-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius Phytochemistry 2009 70(10):1277-85 PubMed ID: 19683319 DOI: 10.1016/j.phytochem.2009.07.020

18311 Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A. Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter J Nucl Med 2008 49(4):615-22 PubMed ID: 18344442 DOI: 10.2967/jnumed.107.048231

18334 Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T. Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release Biosci Biotechnol Biochem 2008 72(9):2481-4 PubMed ID: 18776661 DOI: 10.1271/bbb.80362

13878 Tanaka Y, Goto K, Matsumoto Y, Ueoka R. Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis Int J Pharm 2008 359(1-2):264-71 PubMed ID: 18511224 DOI: 10.1016/j.ijpharm.2008.03.045

16645 Li F, Awale S, Tezuka Y, Kadota S. Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship Bioorg Med Chem 2008 16(10):5434-40 PubMed ID: 18440233 DOI: 10.1016/j.bmc.2008.04.016

17238 Matsuda Y, Yamamoto T, Kudo M, Kawahara K, Kawamoto M, Nakajima Y, Koizumi K, Nakazawa N, Ishiwata T, Naito Z. Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma Int J Oncol 2008 33(6):1177-85 PubMed ID: 19020750

18608 Chen H, Zhang L, Jin Z, Jin E, Fujiwara M, Ghazizadeh M, Asoh S, Ohta S, Kawanami O. Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats Exp Mol Pathol 2007 83(3):377-84 PubMed ID: 17959170 DOI: 10.1016/j.yexmp.2007.08.016

3581 Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K. Biologically active triterpenoid saponins from Ardisia japonica. J Nat Prod 2007 70(2):179-87 PubMed ID: 17243725 DOI: 10.1021/np0604681

9059 Y-C Jung, E Mizuki, T Akao, J-C Côté Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells J Appl Microbiol 2007 103 (1), 65-79 PubMed ID: 17584453 DOI: 10.1111/j.1365-2672.2006.03260.x

16537 Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK. E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers Clin Cancer Res 2007 13(10):3043-50 PubMed ID: 17505007 DOI: 10.1158/1078-0432.CCR-06-2103

19312 Yabuta N, Onda H, Watanabe M, Yoshioka N, Nagamori I, Funatsu T, Toji S, Tamai K, Nojima H. Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest Nucleic Acids Res 2006 34(17):4878-92. PubMed ID: 16973895 DOI: 10.1093/nar/gkl651

6150 Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA. Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells. Oncogene 2006 25(8):1216-24 PubMed ID: 16247456 DOI: 10.1038/sj.onc.1209158

6458 Misumi T, Tanaka T, Mikawa K, Nishina K, Morikawa O, Obara H. Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells. J Anesth 2006 20(3):159-65 PubMed ID: 16897233 DOI: 10.1007/s00540-006-0391-z

9054 Naoko Asaoka, Yasuko Tanaka, Tatsuya Sakai, Yutaka Fujii, Reiko Ohuchi, Masanobu Ohuchi Low Growth Ability of Recent Influenza Clinical Isolates in MDCK Cells Is Due to Their Low Receptor Binding Affinities Microbes Infect 2006 8 (2), 511-9 PubMed ID: 16300986 DOI: 10.1016/j.micinf.2005.08.006

14324 Gene expression profile changes correlating with radioresistance in human cell lines Gene expression profile changes correlating with radioresistance in human cell lines Int J Radiat Oncol Biol Phys 2006 65(1):234-4 PubMed ID: 16618578 DOI: 10.1016/j.ijrobp.2005.12.048

16074 Kawauchi S, Sato S, Morimoto Y, Kikuchi M. Intracellular kinetics of ATX-S10.Na(II) and its correlation with photochemical reaction dynamics during a pulsed photosensitization process: effect of pulse repetition rate J Biomed Opt 2006 11(1):014005 PubMed ID: 16526882 DOI: 10.1117/1.2160387

3413 Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells. J Biochem 2005 138:663-72 PubMed ID: 16428294 DOI: 10.1093/jb/mvi177

2892 Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis J Biochem (Tokyo) 2005 137:17-25 PubMed ID: 15713879 DOI: 10.1093/jb/mvi003

3412 Okajima, Shuhei, Yamaguchi, Takeo, Sakai, Yasuyuki, Nakao, Shin-ichi Regulation of cell adhesion using a signal-responsive membrane substrate. Biotechnol Bioeng 2005 91:237-43 PubMed ID: 15892056 DOI: 10.1002/bit.20512

3409 Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer. Genes Chromosomes Cancer 2005 44:405-14 PubMed ID: 16114034 DOI: 10.1002/gcc.20253

3021 Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T. Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth. FEBS Lett 2005 579(17):3829-36 PubMed ID: 15978581 DOI: 10.1016/j.febslet.2005.06.004

3022 Yano Y, Satoh H, Fukumoto K, Kumadaki I, Ichikawa T, Yamada K, Hagiwara K, Yano T. Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol. Int J Cancer 2005 115(5):839-46 PubMed ID: 15723336 DOI: 10.1002/ijc.20809

9048 Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines J Agric Food Chem 2005 53 (16), 6313-8 PubMed ID: 16076112 DOI: 10.1021/jf0506129

16489 Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S. Proteomic signatures for histological types of lung cancer Proteomics 2005 5(11):2939-48 PubMed ID: 15996008 DOI: 10.1002/pmic.200401166

2894 Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells. J Biol Chem 2004 279:21282-6 PubMed ID: 15026424 DOI: 10.1074/jbc.M401881200

2708 Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T. Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells. J. Exp. Clin. Cancer Res. 2004 23:69-75 PubMed ID: 15149153

5416 Araki K, Hashimoto K, Ardyanto TD, Osaki M, Shomori K, Nakamura H, Ito H. Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas. Lung Cancer 2004 45(2):161-9 PubMed ID: 15246187 DOI: 10.1016/j.lungcan.2004.01.013

2931 Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, KeQin X, Masuda A, Takahashi T, Kitamura H. K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma. Am J Pathol 2004 164(1):91-100 PubMed ID: 14695323 DOI: 10.1016/S0002-9440(10)63100-8

3191 Akasaki K1, Nakamura N, Tsukui N, Yokota S, Murata S, Katoh R, Michihara A, Tsuji H, Marques ET Jr, August JT. Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes. Arch Biochem Biophys 2004 425(2):147-57 PubMed ID: 15111122 DOI: 10.1016/j.abb.2004.02.042

3333 Kawauchi S, Sato S, Morimoto Y, Kikuchi M. Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation time. Photochem Photobiol 2004 80(2):216-23 PubMed ID: 15244505 DOI: 10.1562/2004-03-27-RA-125

9043 Hironaga Kamiyama, Kunikazu Kurosaki, Masanori Kurimoto, Toyomasa Katagiri, Yusuke Nakamura, Masahiko Kurokawa, Hitoshi Sato, Shunro Endo, Kimiyasu Shiraki Herpes Simplex Virus-Induced, Death Receptor-Dependent Apoptosis and Regression of Transplanted Human Cancers Cancer Sci 2004 95 (12), 990-8 PubMed ID: 15596049 DOI: 10.1111/j.1349-7006.2004.tb03188.x

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