CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0098 : A549]

2114 Honma M, Hayashi M, Ohno T, Mizusawa H, Saijo K, Sofuni T. Heterogeneity of the Y chromosome following long-term culture of the human lung cancer cell line A549. In Vitro Cell Dev Biol Anim 1996 32(5):262-4 PubMed ID: 8792154

4609 Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 1976 17(1):62-70 PubMed ID: 175022 DOI: 10.1002/ijc.2910170110

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20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20391 Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H. Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs. J Biosci Bioeng 2022 PubMed ID: 34789413 DOI: 10.1016/j.jbiosc.2021.10.001

20408 Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K. Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology. Acta Cytol 2022 1-6 PubMed ID: 34644702 DOI: 10.1159/000519335

20410 Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T. Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells. Radiat Res 2022 PubMed ID: 34634126 DOI: 10.1667/RADE-21-00112.1

20486 Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y. Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells. Oncol Rep 2022 47(2) PubMed ID: 34935060 DOI: 10.3892/or.2021.8243

16353 Tsujiya Y, Hasegawa A, Yamamori M, Okamura N. Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines Biol Pharm Bull 2022 45(3):276-283 PubMed ID: 35228393 DOI: 10.1248/bpb.b21-00785

20590 Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T. High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells. Molecules 2022 27(4) PubMed ID: 35209077 DOI: 10.3390/molecules27041287

20595 Matsushige T, Sakabe T, Umekita Y. Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line. Yonago Acta Med 2022 65(1):44-52 PubMed ID: 35221759 DOI: 10.33160/yam.2022.02.006

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20674 Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y. The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets. Cell Rep 2022 39(4):110721 PubMed ID: 35476996 DOI: 10.1016/j.celrep.2022.110721

20684 Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O. Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis. Transl Oncol 2022 21:101431 PubMed ID: 35452996 DOI: 10.1016/j.tranon.2022.101431

16485 Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M. Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration Int J Mol Sci 2022 23(9):5047 PubMed ID: 35563439 DOI: 10.3390/ijms23095047

16496 Siswanto FM, Tamura A, Sakuma R, Imaoka S. Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway Mol Pharmacol 2022 101(4):257-273 PubMed ID: 35193967 DOI: 10.1124/molpharm.121.000475

16710 Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka A vitamin D C/D ring-derived compound with cytotoxicity Medicinal Chemistry Research 2022 1120-1125 DOI: 10.1007/s00044-021-02842-2

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20808 Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity Chemical and Pharmaceutical Bulletin 2022 477-482 PubMed ID: 35786566 DOI: 10.1248/cpb.c21-01087

16959 Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells Medicinal Chemistry Research 2022 31:1584-1593 DOI: 10.1007/s00044-022-02939-2

20884 Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T. Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells. In Vivo 2022 36(5):2116-2125 PubMed ID: 36099100 DOI: 10.21873/invivo.12937

20896 Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K. Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network. Acta Cytol 2022 1-9 PubMed ID: 36067744 DOI: 10.1159/000526098

20912 Kotani N, Nakano T, Kuwahara R. Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis. J Biol Chem 2022 298(11):102500 PubMed ID: 36152751 DOI: 10.1016/j.jbc.2022.102500

12851 Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M. Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M Bioorg Chem 2021 107:104627 PubMed ID: 33476868 DOI: 10.1016/j.bioorg.2021.104627

13332 Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K. Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer. Oncol Rep 2021 PubMed ID: 33155667 DOI: 10.3892/or.2020.7839

20016 Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T. Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells. Sci Rep 2021 11(1):1492 PubMed ID: 33452347 DOI: 10.1038/s41598-021-81077-y

20076 Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K. Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines. Biochem Biophys Rep 2021 26:100946 PubMed ID: 33644423 DOI: 10.1016/j.bbrep.2021.100946

13718 Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H. miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells Mol Biol Rep 2021 Mar 6 PubMed ID: 33675467 DOI: 10.1007/s11033-021-06255-7

13912 Yamamoto S, Nakanishi J. Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle Anal Sci 2021 37(5):741-745 PubMed ID: 33390415 DOI: 10.2116/analsci.20SCP16

20145 Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R. Screening for inhibitory effects of crude drugs on furin-like enzymatic activities. J Nat Med 2021 PubMed ID: 33928494 DOI: 10.1007/s11418-021-01519-9

20147 Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol 2021 4(1):490 PubMed ID: 33883697 DOI: 10.1038/s42003-021-02003-6

14339 Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S. GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection mBio 2021 e0326920 PubMed ID: 34061598 DOI: 10.1128/mBio.03269-20

20205 Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K. Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. Food Chem Toxicol 2021 154:112319 PubMed ID: 34087405 DOI: 10.1016/j.fct.2021.112319

20278 Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A. Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein. Eur J Med Chem 2021 215:113288 PubMed ID: 33640763 DOI: 10.1016/j.ejmech.2021.113288

15273 Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T. Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse Prostaglandins Other Lipid Mediat 2021 Jul 9 PubMed ID: 34252545 DOI: 10.1016/j.prostaglandins.2021.106580

15490 Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H. LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence Transl Oncol 2021 14(11):101212 PubMed ID: 34461558 DOI: 10.1016/j.tranon.2021.101212

15504 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency Nat Commun 2021 12(1):5041 PubMed ID: 34413299 DOI: 10.1038/s41467-021-25249-4

20362 Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H. Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells. Biochem Biophys Res Commun 2021 577:146-151 PubMed ID: 34517212 DOI: 10.1016/j.bbrc.2021.09.015

20363 Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C. Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin. Anticancer Res 2021 41(9):4321-4331 PubMed ID: 34475052 DOI: 10.21873/anticanres.15237

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

20423 Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T. Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells. Histochem Cell Biol 2021 155(6):637-653 PubMed ID: 33974136 DOI: 10.1007/s00418-021-01966-1

15879 Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K. 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2 iScience 2021 24(10):103120 PubMed ID: 34541466 DOI: 10.1016/j.isci.2021.103120

15881 Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS. SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis Nat Commun 2021 12(1):6602 PubMed ID: 34782627 DOI: 10.1038/s41467-021-26910-8

20510 Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N. Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device. Toxics 2021 9(12) PubMed ID: 34941765 DOI: 10.3390/toxics9120331

16119 Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y. Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation Pathol Int 2021 71(1):15-23 PubMed ID: 33112501 DOI: 10.1111/pin.13040

16128 Sato Y, Yoshino H, Kashiwakura I, Tsuruga E. DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells Int J Mol Sci 2021 22(1):420 PubMed ID: 33401559 DOI: 10.3390/ijms22010420

16219 Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma Cancer Sci 2021 112(12):5114-5126 PubMed ID: 34628698 DOI: 10.1111/cas.15160

16225 M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells Folia Biol (Praha) 2021 67(2):62-69. PubMed ID: 34624938

16231 Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A. Upregulation of Chemoresistance by Mg 2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells Cells 2021 10(5):1179 PubMed ID: 34066059 DOI: 10.3390/cells10051179

16523 Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis Particle & Particle Systems Characterization 2021 38:2100003 DOI: 10.1002/ppsc.202100003

6923 Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A. Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells. Biochim Biophys Acta Mol Cell Res. 2020 1867(4):118642 PubMed ID: 31923533 DOI: 10.1016/j.bbamcr.2019.118642

9729 Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts Exp Cell Res 2020 391(2):112010 PubMed ID: 32305327 DOI: 10.1016/j.yexcr.2020.112010

9819 Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis Biosci Biotechnol Biochem 2020 84(4):757-763 PubMed ID: 31868102 DOI: 10.1080/09168451.2019.1706442

11986 Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K. Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus. J. Radiat. Res. 2020 61(2):237-242. PubMed ID: 31904079 DOI: 10.1093/jrr/rrz098

12065 Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T. Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells. Biochim Biophys Acta Mol Cell Biol Lipids 2020 PubMed ID: 32112978 DOI: 10.1016/j.bbalip.2020.158675

12375 Morita S, Horii T, Kimura M, Hatada I. Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform Int J Mol Sci 2020 21(5):1574 PubMed ID: 32106616 DOI: 10.3390/ijms21051574

12376 Uddin M, Kawami M, Yumoto R, Takano M. Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells Naunyn Schmiedebergs Arch Pharmacol 2020 393(5):889-896 PubMed ID: 31900520 DOI: 10.1007/s00210-019-01802-3

12607 Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A. Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair Oncol Res 2020 28(2):161-175 PubMed ID: 31727206 DOI: 10.3727/096504019X15736439848765

12989 Endo M, Ohba K, Sato S, Yokota Y, Takahashi K. Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells. Genes Cells 2020 PubMed ID: 32314441 DOI: 10.1111/gtc.12776

12990 Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A. Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression. Nutrients 2020 PubMed ID: 32340376 DOI: 10.3390/nu12041190

12998 Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H. Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds. Appl Radiat Isot 2020 PubMed ID: 32561042 DOI: 10.1016/j.apradiso.2020.109201

13002 Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K. Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway. Respir Investig 2020 PubMed ID: 32359980 DOI: 10.1016/j.resinv.2020.01.003

13021 Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K. Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation. PLoS One 2020 PubMed ID: 32374749 DOI: 10.1371/journal.pone.0232724

13089 Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y. Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions. Sci Rep 2020 PubMed ID: 32612147 DOI: 10.1038/s41598-020-67488-3

13167 Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N. Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy. Biochem Biophys Res Commun 2020 PubMed ID: 32828300 DOI: 10.1016/j.bbrc.2020.07.082

13228 Togami K, Maruta Y, Nanbu M, Tada H, Chono S. Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis. Drug Dev Ind Pharm 2020 PubMed ID: 32940095 DOI: 10.1080/03639045.2020.1825473

13260 Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y. Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis. Immun Inflamm Dis 2020 PubMed ID: 33016012 DOI: 10.1002/iid3.355

13295 Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y. Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells. Oncol Lett 2020 PubMed ID: 33133262 DOI: 10.3892/ol.2020.12226

13342 Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N. Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity. Nanomaterials (Basel) 2020 PubMed ID: 33202926 DOI: 10.3390/nano10112250

13432 Kenta Shinha, Wataru Nihei, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies Biomicrofluidics 2020 DOI: 10.1063/5.0011545

13523 Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549 bioRxiv 2020 October 0４ DOI: 10.1101/2020.10.02.323881

13535 RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells DNA Repair (Amst) 2020 91-92:102872 PubMed ID: 32502756 DOI: 10.1016/j.dnarep.2020.102872

13568 Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI) Authorea Preprints 2020 DOI: 10.22541/au.158316431.10469346

13622 Sato Y, Yoshino H, Tsuruga E, Kashiwakura I. Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation Curr Cancer Drug Targets 2020 20(5):372-381 PubMed ID: 31951181 DOI: 10.2174/1568009620666200115161717

13767 Togami K, Yamaguchi K, Tada H, Chono S. Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis Pharmazie 2020 75(8):371-374 PubMed ID: 32758335 DOI: 10.1691/ph.2020.0048

13841 Eguchi R, Wakabayashi I. HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer Oncol Rep 2020 44(1):14-28 PubMed ID: 32319650 DOI: 10.3892/or.2020.7580

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14836 Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library Cell Chem Biol 2020 27(6):708-718.e1 PubMed ID: 32402240 DOI: 10.1016/j.chembiol.2020.04.007

14849 Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H. The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD Free Radic Res 2020 54(11-12):829-840 PubMed ID: 31809610 DOI: 10.1080/10715762.2019.1696965

11371 Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K. Formation of high molecular weight p62 by CORM-3. PLoS ONE 2019 PubMed ID: 30620762 DOI: 10.1371/journal.pone.0210474

4061 Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T. BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION. Radiat Prot Dosimetry 2019 PubMed ID: 30535060 DOI: 10.1093/rpd/ncy249

4759 Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity Molecules 2019 24:3535 PubMed ID: 31574910 DOI: 10.3390/molecules24193535

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11612 Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A. Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve. Genes Cells 2019 PubMed ID: 31234244 DOI: 10.1111/gtc.12712

11634 Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavichb A, Konishic T. Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation. Radiat. Res. 2019 PubMed ID: 30526323 DOI: 10.1667/RR15155.1

11675 Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging CHEMNANOMAT 2019 DOI: 10.1002/cnma.201900289

11808 Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M. Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer. Anticancer Res. 2019 PubMed ID: 31519584 DOI: 10.21873/anticanres.13667

11848 Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M. Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. Cancers (Basel) 2019 PubMed ID: 31614999 DOI: 10.3390/cancers11101550

11864 Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K. Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1. J. Org. Chem. 2019 PubMed ID: 31642324 DOI: 10.1021/acs.joc.9b02304

9758 Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line Oncol Lett 2019 17(2):2431-2440 PubMed ID: 30719114 DOI: 10.3892/ol.2018.9869

10357 Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors Eur J Med Chem 2019 82:111648 PubMed ID: 31493743 DOI: 10.1016/j.ejmech.2019.111648

12378 Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T. CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development Oncogene 2019 38(14):2580-2594 PubMed ID: 30531840 DOI: 10.1038/s41388-018-0603-7

12379 Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M. Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis Clin Cancer Res 2019 25(9):2809-2820 PubMed ID: 30728155 DOI: 10.1158/1078-0432.CCR-18-3631

12380 Chinnathambi S, Hanagata N. Photostability of quantum dot micelles under ultraviolet irradiation Luminescence 2019 34(5):472-479 PubMed ID: 30809921 DOI: 10.1002/bio.3618

12381 Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI. Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake Photodiagnosis Photodyn Ther 2019 27:327-335 PubMed ID: 31252141 DOI: 10.1016/j.pdpdt.2019.06.017

12382 Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F. Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma Cancer Sci 2019 110(2):726-733 PubMed ID: 30499156 DOI: 10.1111/cas.13895

9502 Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth. Cancer Cell 2018 33:355-367.e7 PubMed ID: 29533781 DOI: 10.1016/j.ccell.2018.02.004

10702 Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y. Mechanism of recipient cell-dependent differences in exosome uptake. BMC Cancer 2018 18:47 PubMed ID: 29306323 DOI: 10.1186/s12885-017-3958-1

10803 Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M. Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions. Lab Chip 2018 18:1378-1387 PubMed ID: 29658964 DOI: 10.1039/c7lc01280b

10805 Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H. Effects of cationic liposomes with stearylamine against virus infection. Int J Pharm 2018 543:311-317 PubMed ID: 29625169 DOI: 10.1016/j.ijpharm.2018.04.001

11049 Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection. J Infect Dis 2018 217(11):1740-1749 PubMed ID: 29529215 DOI: 10.1093/infdis/jiy081

11076 Toyama K, Nomura W, Kobayakawa T, Tamamura H. Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR. Bioconjug. Chem. 2018 29(6):2050-2057 PubMed ID: 29763296 DOI: 10.1021/acs.bioconjchem.8b00250

11177 Kobayashi A, Konishi T. Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells. J. Radiat. Res. 2018 59(6):754-759 PubMed ID: 30124879 DOI: 10.1093/jrr/rry065

11164 Mogi K, Hayashida K, Yamamoto T. Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel. Anal Sci 2018 34(8):875-880 PubMed ID: 30101880 DOI: 10.2116/analsci.17P462

4072 Takayuki Hirono et al MiR-301a/b function as oncomiRs in non-small-cell lung cancer Integr Mol Med 2018 5: 1-6 DOI: 10.15761/IMM.1000347

4097 Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H. Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay. Virus Res 2018 243:69-74 PubMed ID: 29074234 DOI: 10.1016/j.virusres.2017.10.015

4132 Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S. Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma. Cytotechnology 2018 PubMed ID: 28756527 DOI: 10.1007/s10616-017-0124-1

4133 Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K. Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis. Lung 2018 PubMed ID: 29926178 DOI: 10.1007/s00408-018-0134-6

4134 Sato Y, Yoshino H, Kazama Y, Kashiwakura I. Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer. Mol Med Rep 2018 PubMed ID: 30320341 DOI: 10.3892/mmr.2018.9536

4135 Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y. CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30448176 DOI: 10.1016/j.bbrc.2018.11.055

4136 Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S. Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells. Tohoku J. Exp. Med. 2018 PubMed ID: 29459573 DOI: 10.1620/tjem.244.133

4137 Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H. In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran. Int. J. Biol. Macromol. 2018 PubMed ID: 28964842 DOI: 10.1016/j.ijbiomac.2017.09.085

4138 Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O. Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30446226 DOI: 10.1016/j.bbrc.2018.11.035

4139 Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M. High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma. Pathol. Int. 2018 PubMed ID: 30320419 DOI: 10.1111/pin.12724

4141 Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C. Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells. Oncotarget 2018 PubMed ID: 30220973 DOI: 10.18632/oncotarget.25994

4468 Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y. A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells. Medchemcomm 2018 9(5):783-788 PubMed ID: 30108967 DOI: 10.1039/c8md00010g

7050 Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I. Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma. Oncotarget 2017 8:2890-2905 PubMed ID: 27926516 DOI: 10.18632/oncotarget.13761

10274 Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M. Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark. Chem. Biodivers. 2017 14: PubMed ID: 28425165 DOI: 10.1002/cbdv.201700105

10280 Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A. AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier. Oncol. Rep. 2017 37:3261-3269 PubMed ID: 28440492 DOI: 10.3892/or.2017.5594

10381 Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T. Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling. Mutat. Res. 2017 803-805:1-8 PubMed ID: 28689138 DOI: 10.1016/j.mrfmmm.2017.06.006

10924 Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin RSC Adv 2017 7, 2392-2402 DOI: 10.1039/C6RA26592H

4526 Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2017 818, 7-16 PubMed ID: 28477879 DOI: 10.1016/j.mrgentox.2017.04.002

9171 Haruhiko Fuwa, Mizuho Sato A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells Mar Drugs 2017 15 (10) PubMed ID: 29053565 DOI: 10.3390/md15100320

10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

12213 Cancer Lett Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells 2017 390:160-167 PubMed ID: 28093283 DOI: 10.1016/j.canlet.2017.01.006

12218 Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis J Pharmacol Toxicol Methods 2017 86:19-27. PubMed ID: 28259823 DOI: 10.1016/j.vascn.2017.02.023

14030 El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M. Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2 Biomed Pharmacother 2017 85:549-555 PubMed ID: 27889230 DOI: 10.1016/j.biopha.2016.11.063

14081 Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models Allergy 2017 72(7):1043-1053. PubMed ID: 27878831 DOI: 10.1111/all.13079

14432 Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M. miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma Cancer Sci 2017 108(3):536-542 PubMed ID: 28012229 DOI: 10.1111/cas.13148

14529 Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R. Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells Radiat Res 2017 188(5):591-594 PubMed ID: 28829673 DOI: 10.1667/RR14824.1

14665 Takahashi K, Ohta T. Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells Biochem Biophys Res Commun 2017 490(3):587-593 PubMed ID: 28629997 DOI: 10.1016/j.bbrc.2017.06.082

14674 Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y. Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy J Am Chem Soc 2017 139(39):13713-13719 PubMed ID: 28872304 DOI: 10.1021/jacs.7b05019

14730 Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T. Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells Sci Rep 2017 7(1):12317. PubMed ID: 28951614 DOI: 10.1038/s41598-017-12017-y

16608 Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C. Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents Anticancer Res 2017 37(11):6177-6188 PubMed ID: 29061799 DOI: 10.21873/anticanres.12067

7063 Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I. Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. Nat. Biotechnol. 2016 34:1060-1065 PubMed ID: 27571369 DOI: 10.1038/nbt.3658

7193 Yamazoe H, Hagihara Y, Kobayashi H. Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs. Tissue Eng Part C Methods 2016 22:20-9 PubMed ID: 26421875 DOI: 10.1089/ten.TEC.2015.0188

9581 Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A. Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells. Biochim. Biophys. Acta 2016 1863:1170-8 PubMed ID: 26919807 DOI: 10.1016/j.bbamcr.2016.02.015

9774 Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H. Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone. Virus Res. 2016 223:170-80 PubMed ID: 27485920 DOI: 10.1016/j.virusres.2016.07.011

9884 Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C. Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin. Anticancer Res. 2016 36:6083-6092 PubMed ID: 27793936 DOI: 10.21873/anticanres.11198

9117 Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis PLoS One 2016 11 (1), e0147957 PubMed ID: 26807591 DOI: 10.1371/journal.pone.0147957

10117 Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy Biomater Sci . 2016 4(5):826-38 PubMed ID: 26971562 DOI: 10.1039/c6bm00011h

12614 Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M. Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage J Biochem 2016 159(2):225-37 PubMed ID: 26378248 DOI: 10.1093/jb/mvv098

12629 Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C. Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine Anticancer Res 2016 36(12):6311-6318 PubMed ID: 27919951 DOI: 10.21873/anticanres.11227

12630 Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C. The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo Oncotarget 2016 7(19):27021-32 PubMed ID: 27027242 DOI: 10.18632/oncotarget.8395

12631 Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J. Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer Transl Oncol 2016 9(3):203-10 PubMed ID: 27267838 DOI: 10.1016/j.tranon.2016.03.007

12646 Husni RE, Shiba-Ishii A, Iiyama S, Shiozawa T, Kim Y, Nakagawa T, Sato T, Kano J, Minami Y, Noguchi M. DNMT3a expression pattern and its prognostic value in lung adenocarcinoma Lung Cancer 2016 97:59-65 PubMed ID: 27237029 DOI: 10.1016/j.lungcan.2016.04.018

12681 Toyama K, Mizuguchi T, Nomura W, Tamamura H. Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization Bioorg Med Chem 2016 24(16):3406-12 PubMed ID: 27283787 DOI: 10.1016/j.bmc.2016.05.026

12948 Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K. Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2 Cancer Sci 2016 107(9):1321-8 PubMed ID: 27324116 DOI: 10.1111/cas.12995

12949 Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I. p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines BMC Cancer 2016 16:521 PubMed ID: 27456853 DOI: 10.1186/s12885-016-2585-6

12974 Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation Part Fibre Toxicol 2016 13:16 PubMed ID: 27026438 DOI: 10.1186/s12989-016-0127-7

13469 Tanabe K. Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization Sci Rep 2016 6:25095 PubMed ID: 27117592 DOI: 10.1038/srep25095

13976 Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R. Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair Cancer Sci 2016 107(9):1250-5 PubMed ID: 27341700 DOI: 10.1111/cas.12998

13996 Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M. Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers Bioconjug Chem 2016 27(10):2307-2314 PubMed ID: 27580353 DOI: 10.1021/acs.bioconjchem.6b00255

14026 Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C. Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance Anticancer Res 2016 36(10):5153-5161 PubMed ID: 27798875 DOI: 10.21873/anticanres.11085

14028 Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H. A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam PLoS One 2016 11(11):e0166848 PubMed ID: 27875573 DOI: 10.1371/journal.pone.0166848

14041 Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T. Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark Chem Biodivers 2016 13(11):1601-1609 PubMed ID: 27492128 DOI: 10.1002/cbdv.201600247

14095 Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells Nanoscience and Nanotechnology Letters 2016 8:310-315 DOI: 10.1166/nnl.2016.2132

17169 Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y. Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae) J Nat Med 2016 70(2):241-52 PubMed ID: 26825781 DOI: 10.1007/s11418-016-0967-3

5653 Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H. Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems. Anticancer Res 2015 35(8):4411-7 PubMed ID: 26168480

14286 Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N. Prognostic significance of MYH9 expression in resected non-small cell lung cancer PLoS One 2015 10(3):e0121460 PubMed ID: 25826333 DOI: 10.1371/journal.pone.0121460

14460 Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I. Effects of X‑ray irradiation in combination with ascorbic acid on tumor control Mol Med Rep 2015 12(4):5449-54 PubMed ID: 26238154 DOI: 10.3892/mmr.2015.4108

14953 Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y. A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents Anticancer Res 2015 35(11):5851-5 PubMed ID: 26504007

15015 Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E. Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells Yonago Acta Med 2015 58(1):31-8 PubMed ID: 26190895

15069 Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T. Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels Chem Biodivers 2015 12(4):547-58 PubMed ID: 25879500 DOI: 10.1002/cbdv.201400424

15117 Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A. Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer Mol Cancer Ther 2015 14(11):2433-40 PubMed ID: 26351321 DOI: 10.1158/1535-7163.MCT-15-0050

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16547 Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, Suzuki T, Koike K, Akihisa R, Akihisa T. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities Chem Biodivers 2014 11(7):987-1000 PubMed ID: 25044585 DOI: 10.1002/cbdv.201400052

16548 Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T. Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities Chem Biodivers 2014 11(1):73-84 PubMed ID: 24443427 DOI: 10.1002/cbdv.201300266

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