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Cell No. : Cell Name
RCB0083 : HLC-1  update : 2023/01/26
CommentLung adenocarcinoma
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Okabe, Tetsuro
Originator Okabe, Tetsuro
Year of deposit 1986
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Unknown
Tissue lung
Disease name adenocarcinoma
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_5529
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium HamF12 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Isozyme LD, NP
Chromosome mode 65-235(50) : /91(3),92(5),93(1),94(4),95(2),96(1)/
STR(human) OK
deposit info
lot info
Reference information Reference 0
User's Publication 15

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User's Publication
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667   DOI: 10.3892/or.2020.7839
11379  Omoto K, Matsuda R, Nakai Y, Tatsumi Y, Nakazawa T, Tanaka Y, Shida Y, Murakami T, Nishimura F, Nakagawa I, Motoyama Y, Nakamura M, Fujimoto K, Hiroyuki N.  Expression of peptide transporter 1 has a positive correlation in protoporphyrin IX accumulation induced by 5-aminolevulinic acid with photodynamic detection of non-small cell lung cancer and metastatic brain tumor specimens originating from non-small cell lung cancer.  Photodiagnosis Photodyn Ther  2019    PubMed ID: 30639584   DOI: 10.1016/j.pdpdt.2019.01.009
10585  Homma S, Hayashi K, Yoshida K, Sagawa Y, Kamata Y, Ito M.  Nafamostat mesilate, a serine protease inhibitor, suppresses interferon-gamma-induced up-regulation of programmed cell death ligand 1 in human cancer cells.  Int. Immunopharmacol.  2018  54:39-45  PubMed ID: 29100036   DOI: 10.1016/j.intimp.2017.10.016
4231  Yamaura T, Ezaki J, Okabe N, Takagi H, Ozaki Y, Inoue T, Watanabe Y, Fukuhara M, Muto S, Matsumura Y, Hasegawa T, Hoshino M, Osugi J, Shio Y, Waguri S, Tamura H, Imai JI, Ito E, Yanagisawa Y, Honma R, Watanabe S, Suzuki H.  Family with sequence similarity 83, member B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild-type epidermal growth factor receptor.  Oncol Lett  2018    PubMed ID: 29434849   DOI: 10.3892/ol.2017.7517
10378  Tsubouchi H, Onomura H, Saito Y, Yanagi S, Miura A, Matsuo A, Matsumoto N, Nakazato M.  Ghrelin does not influence cancer progression in a lung adenocarcinoma cell line.  Endocr. J.  2017  64:S41-S46  PubMed ID: 28652543   DOI: 10.1507/endocrj.64.S41
17162  Kimura M, Naito H, Tojo T, Itaya-Hironaka A, Dohi Y, Yoshimura M, Nakagawara K, Takasawa S, Taniguchi S.  REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms  Oncol Rep  2013  30(6):2625-31  PubMed ID: 24065141   DOI: 10.3892/or.2013.2739
5867  Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H.  Secreted form of EphA7 in lung cancer.  Int J Oncol  2010  36(3):635-40  PubMed ID: 20126984  
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
17469  Takiguchi Y, Miyamoto T, Nagao K, Kuriyama T.  Assessment of the homogeneous efficacy of carbon ions in the spread-out Bragg peak for human lung cancer cell lines  Radiat Med  2007  25(6):272-7  PubMed ID: 17634880   DOI: 10.1007/s11604-007-0134-6
13698  Matsubara D, Niki T, Ishikawa S, Goto A, Ohara E, Yokomizo T, Heizmann CW, Aburatani H, Moriyama S, Moriyama H, Nishimura Y, Funata N, Fukayama M.  Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes  Cancer Sci  2005  96(12):844-57  PubMed ID: 16367903   DOI: 10.1111/j.1349-7006.2005.00121.x
16491  Nakanishi H, Suda T, Katoh M, Watanabe A, Igishi T, Kodani M, Matsumoto S, Nakamoto M, Shigeoka Y, Okabe T, Oshimura M, Shimizu E.  Loss of imprinting of PEG1/MEST in lung cancer cell lines  Oncol Rep  2004  12(6):1273-8  PubMed ID: 15547750  
13743  Niki T, Kohno T, Iba S, Moriya Y, Takahashi Y, Saito M, Maeshima A, Yamada T, Matsuno Y, Fukayama M, Yokota J, Hirohashi S.  Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas  Am J Pathol  2002  160(3):1129-41  PubMed ID: 11891209   DOI: 10.1016/s0002-9440(10)64933-4
2483  Niki T, Iba S, Tokunou M, Yamada T, Matsuno Y, Hirohashi S  Expression of vascular endothelial growth factors A, B, C, and D and their relationships to lymph node status in lung adenocarcinoma.  Clin Cancer Res  2000  6:2431-9  PubMed ID: 10873096  
18751  Sasaki Y, Takahashi T, Miyazaki H, Matsumoto A, Kato T, Nakamura K, Iho S, Okuno Y, Nakao K.  Production of thrombopoietin by human carcinomas and its novel isoforms  Blood  1999  94(6):1952-60  PubMed ID: 10477724  
17903  Oshima M, Sugiyama H, Kitagawa K, Taketo M.  APC gene messenger RNA: novel isoforms that lack exon 7  Cancer Res  1993  53(23):5589-91  PubMed ID: 8242607  

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