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Cell No. : Cell Name
RCB0041 : HL60  update : 2024/08/14
CommentHuman cell line derived from promyelocytic leukemia. Differentiates to granulocytes and macrophages.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Ohno, Tadao
Year of deposit 1986
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Tissue blood
Disease name promyelocytic leukemia
Classification cancer
History Tokyo Uni.
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_0002
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture method 浮遊細胞の培養に関する一般的な注意(Japanese)
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Virus (HIV) (-)
Virus (HTLV-1) (-)
Chromosome mode 44-175(50) : 44(8),45(15),46(4),87(1),88(6)/
STR(human) OK
Images
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lot info
Reference information Reference 10
User's Publication 259


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Reference
146  Huang XJ, Wiernik PH, Klein RS, Gallagher RE.  Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases  Med Oncol  1999  16(1):58-64  PubMed ID: 10382944   DOI: 10.1007/BF02787360
1468  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  A Gene Coding for a Zinc Finger Protein Is Induced during 12-O-Tetradecanoylphorbol-13-Acetate-Stimulated HL-60 Cell Differentiation  J Biochem  1992  111:272-277  PubMed ID: 1569051   DOI: 10.1093/oxfordjournals.jbchem.a123748
1467  Oguro K, Sakamoto K, Kitajima K, Oda T, Hirano T, Shimizu N, Utiyama H  Determination of Transcriptional Activities of Typical Gene Promoters in HL-60  J Biochem  1992  111:103-108  PubMed ID: 1607356   DOI: 10.1093/oxfordjournals.jbchem.a123704
1466  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells.  J Biol Chem  1991  266:12157-61  PubMed ID: 2061303  
2033  Drexler, H G, Otsuka K, Gaedicke G, Minowada J  Changes in isoenzyme profiles during induction of differentiation in human myelomonocytic leukemia cell lines.  Cancer Res  1986  46:6078-82  PubMed ID: 2946400  
5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  83(20):7898-902  PubMed ID: 3464004   DOI: 10.1073/pnas.83.20.7898
697  Hozumi M  Established leukemia cell lines: their role in the understanding and control of leukemia proliferation.  Crit Rev Oncol Hematol  1985  3:235-77  PubMed ID: 3899390   DOI: 10.1016/s1040-8428(85)80028-7
145  Gallagher RE, Ferrari AC, Zulich AW, Testa JR.  Variable differentiative response of 6-thioguanine-resistant HL60 sublines: possible relationship to double-minute chromosomes  Prog Nucleic Acid Res Mol Biol  1983  29:283-6  PubMed ID: 6582531  
144  Gallagher R, Collins S, Trujillo J, McCredie K, Ahearn M, Tsai S, Metzgar R, Aulakh G, Ting R, Ruscetti F, Gallo R.  Characterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia  Blood  1979  54(3):713-33  PubMed ID: 288488  
973  Collins, S J, Gallo, R C, Gallagher, R E  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.  Nature  1977  270:347-9  PubMed ID: 271272   DOI: 10.1038/270347a0

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User's Publication
21604  Nishimori M, Hayasaka N, Otsui K, Inoue N, Asakura J, Nagao M, Toh R, Ishida T, Hirata KI, Furuyashiki T, Shinohara M.  Stress-induced stenotic vascular remodeling via reduction of plasma omega-3 fatty acid metabolite 4-oxoDHA by noradrenaline.  Sci Rep  2024  14(1):4178  PubMed ID: 38378892   DOI: 10.1038/s41598-024-54867-3
21818  Morino Y, Sugiyama H, Yamane K, Kikuchi M, Yamanaka T, Honda K, Monzen S.vvv  Additive antitumor effect of arsenic trioxide with exposure to ionizing radiation to human acute promyelocytic leukemia HL‑60 cells.  Oncol Rep  2024  52(2)  PubMed ID: 38963046   DOI: 10.3892/or.2024.8768
19746  Usukhbayar N, Takano Y, Uesugi S, Muroi M, Osada H, Kimura KI.  3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation  Free Radic Res  2023  57(3):208-222  PubMed ID: 37347979   DOI: 10.1080/10715762.2023.2229005
21228  Paulin DA, Koseki T, Usukhbayar N, Kimura KI, Shiono Y.  Cytotoxicity and Induction of G1 Phase Cell Cycle Arrest in human acute promyelocytic leukemia HL60 cells by indole alkaloids isolated from Dialium corbisieri seeds.  Biosci Biotechnol Biochem  2023    PubMed ID: 37245061   DOI: 10.1093/bbb/zbad067
21504  Yamazoe H.  Multifunctional Micromachines Constructed by Combining Multiple Protein-Based Components with Different Functions.  ACS Appl Mater Interfaces  2023    PubMed ID: 38078429   DOI: 10.1021/acsami.3c12912
17587  Horiguchi T, Tanimura A, Miyoshi K, Hagita H, Minami H, Noma T.  The Effect of Heterozygous Mutation of Adenylate Kinase 2 Gene on Neutrophil Differentiation  Int J Mol Sci  2022  23(24):16089  PubMed ID: 36555730   DOI: 10.3390/ijms232416089
20533  Kozako T, Kato N, Ohsugi T, Uchida YI, Yoshimitsu M, Ishitsuka K, Higaki Y, Sato H, Aikawa A, Honda SI.  SRT1720 induces SIRT1-independent cell death in adult T-cell leukemia/lymphoma.  FEBS J  2022    PubMed ID: 35029032   DOI: 10.1111/febs.16353
20562  Okue S, Yaguchi M, Miura A, Ozaki-Masuzawa Y, Hosono T, Seki T.  The garlic-derived organosulfur compound diallyl trisulphide suppresses tissue factor function.  Food Funct  2022  13(3):1246-1255  PubMed ID: 35022635   DOI: 10.1039/d1fo02206g
16357  Futokoro R, Hijioka M, Arata M, Kitamura Y.  Lipoxin A 4 Receptor Stimulation Attenuates Neuroinflammation in a Mouse Model of Intracerebral Hemorrhage  Brain Sci   2022  12(2):162  PubMed ID: 35203926   DOI: 10.3390/brainsci12020162
20776  Miyoshi K, Hagita H, Horiguchi T, Tanimura A, Noma T.  Redefining GBA gene structure unveils the ability of Cap-independent, IRES-dependent gene regulation.  Commun Biol  2022  5(1):639  PubMed ID: 35831491   DOI: 10.1038/s42003-022-03577-5
20895  Yoneda Y, Yahagi T, Harada K, Okamoto Y, Motai S, Matsuzaki K, Kubo M, Fukuyama Y, Ohsaki A.  Anchietins A-E: 30-norfriedelane-type triterpenes from Anchietea pyrifolia.  Phytochemistry  2022  203:113388  PubMed ID: 36075316   DOI: 10.1016/j.phytochem.2022.113388
20135  Saitoh Y, Kawasaki N, Eguchi N, Ikeshima M.  Combined treatment with dissolved hydrogen molecule and platinum nanocolloid exerts carcinostatic/carcinocidal effects by increasing hydrogen peroxide generation and cell death in the human gastric cancer cell line NUGC-4.  Free Radic Res  2021  1-10  PubMed ID: 33929281   DOI: 10.1080/10715762.2021.1902514
14478  Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y.  Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on β-Glucan-Specific Antibody Production in Healthy Human Volunteers  Int J Med Mushrooms  2021  23(2):13-28  PubMed ID: 33639078   DOI: 10.1615/IntJMedMushrooms.2020037471
14523  Yamakawa H, Setoguchi S, Goto S, Watase D, Terada K, Nagata-Akaho N, Toki E, Koga M, Matsunaga K, Karube Y, Takata J.  Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K 2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line  Pharmaceutics  2021  13(5):758  PubMed ID: 34065416   DOI: 10.3390/pharmaceutics13050758
15169  Imoto D, Saito N, Nakajima A, Honda G, Ishida M, Sugita T, Ishihara S, Katagiri K, Okimura C, Iwadate Y, Sawai S.  Comparative mapping of crawling-cell morphodynamics in deep learning-based feature space  PLoS Comput Biol  2021  17(8):e1009237  PubMed ID: 34383753   DOI: 10.1371/journal.pcbi.1009237
16280  Marutani T, Nishino K, Miyaji T, Kamada K, Ohura K, Kiso Y, Mukai H.  Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2-Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages  Int J Mol Sci  2021  22(8):4084  PubMed ID: 33920954   DOI: 10.3390/ijms22084084
16716  Kazuyuki Todoroki, Mariko Funasaki, Tadahiro Etoh, Keiichi Matsuzaki, Ayumi Ohsaki  Two Erythrina alkaloids and three diarylpropanoids from Erythrina velutina  Tetrahedron  2021  9:132383    DOI: 10.1016/j.tet.2021.132383
16735  Okada H, Mimura M, Tomita S, Kurita R.  Affinity Diversification of a Polymer Probe for Pattern-recognition-based Biosensing Using Chemical Additives  Anal Sci   2021  37(5):713-719  PubMed ID: 33518589   DOI: 10.2116/analsci.20SCP23
13017  Aoki S, Aboshi T, Shiono Y, Kimura KI, Murata T, Arai D, Iizuka Y, Murayama T.  Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus.  Chem Pharm Bull (Tokyo)  2020    PubMed ID: 32378541   DOI: 10.1248/cpb.c19-01009
13313  Sugihara K, Yamaguchi Y, Usui S, Nashimoto Y, Hanada S, Kiyokawa E, Uemura A, Yokokawa R, Nishiyama K, Miura T.  A new perfusion culture method with a self-organized capillary network.  PLoS One  2020    PubMed ID: 33112918   DOI: 10.1371/journal.pone.0240552
13489  Shoko Ogushi, Shuji Ikemoto, Nobuhiko Miura, Tsuyoshi Nakanishi, Tomoki Kimura  Cadmium Inhibits All-Trans-Retinoic Acid-Induced Increase of Nitroblue Tetrazolium Reduction Activity and Induces Metallothionein 1G Expression in Human Acute Myelocytic Leukemia HL-60 Cells  BPB Reports  2020  3:34-38    DOI: 10.1248/bpbreports.3.1_34
14863  Manami Oyama, Tetsuo Tokiwano, Hiromi Ota, Kouichi Mizuno, Keimei Oh, Satoru Kawaii, Yuko Yoshizawa  β-Sitosterol Oxides From the Dried Stem of Salix gilgiana Inhibit the Proliferation of HL-60 Leukemic Cells  Current Bioactive Compounds  2020  16:329-334    DOI: 10.2174/1573407214666181026110106
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549   DOI: 10.1038/s41467-019-09028-w
11329  Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, Ikematsu K.  Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing.  Diabetes  2019    PubMed ID: 30523028   DOI: 10.2337/db18-0313
11627  Kawashima H, Toyooka N, Okada T, Nguyen HD, Nishikawa Y, Miura Y, Inoue N, Kimura KI.  Identification and Total Synthesis of Two Previously Unreported Odd-Chain Bis-Methylene-Interrupted Fatty Acids with a Terminal Olefin that Activate Protein Phosphatase, Mg2+/Mn2+-Dependent 1A (PPM1A) in Ovaries of the Limpet Cellana toreuma.  Mar Drugs  2019    PubMed ID: 31336763   DOI: 10.3390/md17070410
11652  Tomoki Nakamura, Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Ari Widiyantoro, Rikhsan Kurniatuhadi, Abdul Malik, Suwardi Annas, Desi Harneti, Rani Maharani, Unang Supratman, Junpei Abe, Naoaki Kurisawa, Ken-ich Kimura, Yoshihito Shiono  Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl  Phytochemistry Letters  2019      DOI: 10.1016/j.phytol.2019.03.014
11712  Shota Uesugi, Yuna Honmura, Mami Nishiyama, Kazuaki Kusakabe, Akio Tonouchi, Tetsuro Yamashita, Masaru Hashimoto, Ken-ichi Kimura  Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors  Bioorganic & Medicinal Chemistry  2019    PubMed ID: 31732281   DOI: 10.1016/j.bmc.2019.115161
6943  Yamamoto M, Matsumura R, Hirata Y, Nagamune H.  A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods.  Toxicol In Vitro  2019  54:75-81  PubMed ID: 30240708   DOI: 10.1016/j.tiv.2018.09.009
9810  Junko Shibato, Fumiko Takenoya, Takahiro Hirabayashi, Ai Kimura, Yusuke Iwasaki, Yoko Toyoda, Motohide Hori, Shigeru Tamogami, Randeep Rakwal, Seiji Shioda  Towards Identification of Bioactive Compounds in Cold Vacuum Extracted Double Cherry Blossom (Gosen-Sakura) Leaves  Plant Signal Behav  2019  14(10):e1644594  PubMed ID: 31342859   DOI: 10.1080/15592324.2019.1644594
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478   DOI: 10.1038/s41598-019-44817-9
12283  Masaya Yamaguchi, Yujiro Hirose, Moe Takemura, Masayuki Ono, Tomoko Sumitomo, Masanobu Nakata, Yutaka Terao, Shigetada Kawabata  Streptococcus pneumoniae Evades Host Cell Phagocytosis and Limits Host Mortality Through Its Cell Wall Anchoring Protein PfbA  Front Cell Infect Microbiol  2019  Aug 20;9:301  PubMed ID: 31482074   DOI: 10.3389/fcimb.2019.00301
10497  Tchoukoua A, Kuiate Tabopda T, Konga Simo I, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Shiono Y, Ngadjui BT.  Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae).  Nat. Prod. Res.  2018  32:924-932  PubMed ID: 28868920   DOI: 10.1080/14786419.2017.1371156
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040   DOI: 10.1016/j.biomaterials.2017.10.045
19299  Sano E, Mori C, Nashimoto Y, Yokokawa R, Kotera H, Torisawa YS.  Engineering of vascularized 3D cell constructs to model cellular interactions through a vascular network  Biomicrofluidics  2018  12(4):042204  PubMed ID: 29861815   DOI: 10.1063/1.5027183
10778  Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H, Hosokawa Y.  A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression.  Oncol Lett  2018  15:6709-6714  PubMed ID: 29616132   DOI: 10.3892/ol.2018.8099
10799  Kawai C, Yamauchi A, Kuribayashi F.  Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit.  Microbiol. Immunol.  2018  62:269-280  PubMed ID: 29573449   DOI: 10.1111/1348-0421.12584
11008    New Triterpene saponins from the stem of Acacia kamerunensis (Mimosaceae)  Phytochemistry Letters  2018  23, 21-25    DOI: 10.1016/j.phytol.2017.11.004
11119  Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T.  Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation.  Cell. Physiol. Biochem.  2018  47(5):1936-1950  PubMed ID: 29972819   DOI: 10.1159/000491464
6831  de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu T, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R.  Targeting miR-223 in neutrophils enhances the?clearance of Staphylococcus aureus in infected?wounds.  EMBO Mol Med  2018    PubMed ID: 30171089   DOI: 10.15252/emmm.201809024
6902  Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T.  Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.  BMC Cancer  2018    PubMed ID: 30081901   DOI: 10.1186/s12885-018-4710-1
4095    Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues  RSC Adv  2018  8, 36895-36902  PubMed ID: 35558920   DOI: 10.1039/C8RA07879C
4229  Ariefta NR, Kristiana P, Aboshi T, Murayama T, Tawaraya K, Koseki T, Kurisawa N, Kimura KI, Shiono Y.  New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP.  Fitoterapia  2018    PubMed ID: 29621598   DOI: 10.1016/j.fitote.2018.03.012
4230  Okimura C, Sakumura Y, Shimabukuro K, Iwadate Y.  Sensing of substratum rigidity and directional migration by fast-crawling cells.  Phys Rev E  2018    PubMed ID: 29906928   DOI: 10.1103/PhysRevE.97.052401
14545  Yoshihito Shiono, Mariko Furukawa, Takuya Koseki, Eunsang Kwon, Andreas Hendracipta Kurniawan, Satoru Sato, Desi Harneti, Rani Maharani, Unang Supratman, Shota Uesugi, Ken-ichi Kimura  A pyrrocidine derivative produced by fungus Neonectria ramulariae In-2 isolated from a Beetle Holotrichia picea  Phytochemistry Letters  2018  26:120-124    DOI: 10.1016/j.phytol.2018.05.030
10047  Tchoukoua A, Tabopda TK, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Horo I, Çalişkan ÖA, Shiono Y, Ngadjui BT.  Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).  Phytochemistry  2017  136:31-38  PubMed ID: 28043655   DOI: 10.1016/j.phytochem.2016.12.019
10126  Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557   DOI: 10.1007/s11745-017-4236-3
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165   DOI: 10.1002/cbdv.201700105
10483  Mukai M, Suruga N, Saeki N, Ogawa K.  EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes.  BMC Cell Biol.  2017  18:28  PubMed ID: 28851287   DOI: 10.1186/s12860-017-0144-x
10907  Hosokawa Y, Saga R, Monzen S, Terashima S, Tsuruga E.  Ascorbic acid does not reduce the anticancer effect of radiotherapy  Biomed Rep  2017  6:103-107  PubMed ID: 28123717   DOI: 10.3892/br.2016.819
9126  Abdou Tchoukoua, Turibio Kuiate Tabopda, Narandulam Usukhbayar, Ken-Ichi Kimura, Eunsang Kwon, Hiroyuki Momma, Takuya Koseki, Yoshihito Shiono, Bonaventure Tchaleu Ngadjui   New Triterpene Saponins From the Roots of Acacia Macrostachya (Mimosaceae)  Biosci Biotechnol Biochem  2017  81 (12), 2261-2267  PubMed ID: 29052455   DOI: 10.1080/09168451.2017.1390393
14385  Hattori T, Yamada T, Morikawa H, Marutani T, Tsutsumi K, Nishino K, Shimizu T, Nishi Y, Kiso Y, Mukai H.  Generation of monoclonal antibodies against mitocryptide-2: toward a new strategy to investigate the biological roles of cryptides  J Pept Sci  2017  23(7-8):610-617  PubMed ID: 28370673   DOI: 10.1002/psc.3000
13899  Fujiwara D, Tsubaki M, Takeda T, Tomonari Y, Koumoto YI, Sakaguchi K, Nishida S.  Statins induce apoptosis through inhibition of Ras signaling pathways and enhancement of Bim and p27 expression in human hematopoietic tumor cells  Tumour Biol  2017  1010428317734947  PubMed ID: 28990465   DOI: 10.1177/1010428317734947
7093  Monzen S, Chiba M, Hosokawa Y.  Genetic network profiles associated with established resistance to ionizing radiation in acute promyelocytic leukemia cells and their extracellular vesicles.  Oncol. Rep.  2016  35:749-56  PubMed ID: 26718911   DOI: 10.3892/or.2015.4471
7166  Uesugi S, Fujisawa N, Yoshida J, Watanabe M, Dan S, Yamori T, Shiono Y, Kimura K.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.  J. Antibiot.  2016  69:133-40  PubMed ID: 26506860   DOI: 10.1038/ja.2015.103
10882    Yeast Ca2 +-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2 +-influx  Fitoterapia  2016  113, 188-194  PubMed ID: 27491756   DOI: 10.1016/j.fitote.2016.07.018
10914  Regina Appiah-Opong et al  Antiproliferative, antioxidant activities and apoptosis induction by Morinda lucida and Taraxacum officinale in human HL-60 leukemia cells  Journal of Global Biosciences  2016  7, 4281-4291   
12626  Yutaro Asaba, Shoichiro Asayama & Hiroyoshi Kawakami   Design of epigenetics control carrier for simultaneous transfection of histone acetyltransferase with histone deacetylase inhibitor to continuous histone   Polymer Journal  2016  48:561–564    DOI: 10.1038/pj.2015.129
12649  Shikama Y, Cao M, Ono T, Feng X, Noji H, Kimura H, Ogawa K, Suzuki Y, Ikeda K, Takeishi Y, Kimura J.  Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients  PLoS One  2016  11(8):e0158527.  PubMed ID: 27513856   DOI: 10.1371/journal.pone.0158527
6632  Nakayama T, Saitoh N, Morotomi-Yano K, Yano K, Nakao M, Saitoh H.  Nuclear extrusion precedes discharge of genomic DNA fibers during tunicamycin-induced neutrophil extracellular trap-osis (NETosis)-like cell death in cultured human leukemia cells  Cell Biol Int  2016  40(5):597-602  PubMed ID: 26888435   DOI: 10.1002/cbin.10594
12970  Okimura C, Ueda K, Sakumura Y, Iwadate Y.  Fast-crawling cell types migrate to avoid the direction of periodic substratum stretching  Cell Adh Migr  2016  10(4):331-41  PubMed ID: 26980079   DOI: 10.1080/19336918.2015.1129482
14041  Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T.  Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark  Chem Biodivers  2016  13(11):1601-1609  PubMed ID: 27492128   DOI: 10.1002/cbdv.201600247
14043  Abdou Tchoukoua, Turibio Kuiate Tabopda, Shota Uesugi, Ken-ichi Kimura, Eunsang Kwon, Hiroyuki Momma, Bonaventure Tchaleu Ngadjui, Takuya Koseki, Yoshihito Shiono  Two new 5-deoxyflavan-3,4-diol glucosides from roots of Albizia chevalieri  Magnetic Resonance in Chemistry  2016  54:893-896  PubMed ID: 27546306   DOI: 10.1002/mrc.4504
15303  Yoshihito Shiono, Nozomi Miyazaki, Tetsuya Murayama, Takuya Koseki, Harizon, Dewa Gede Katja, Unang Supratman, Juri Nakata, Yoshito Kakihara, Makio Saeki, Jun Yoshida, Shota Uesugi, Ken-ichi Kimura  GSK-3β inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant  Phytochemistry Letters  2016  18:122-127    DOI: 10.1016/j.phytol.2016.09.007
16390  Nakajima A, Ishida M, Fujimori T, Wakamoto Y, Sawai S.  The microfluidic lighthouse: an omnidirectional gradient generator  Lab Chip  2016  16(22):4382-4394  PubMed ID: 27735954   DOI: 10.1039/c6lc00898d
7138  Nagashima H.  Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.  Environ. Toxicol. Pharmacol.  2015  40:997-1000  PubMed ID: 26595743   DOI: 10.1016/j.etap.2015.10.012
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15069  Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T.  Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels  Chem Biodivers  2015  12(4):547-58  PubMed ID: 25879500   DOI: 10.1002/cbdv.201400424
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17465  Kitai Y, Hayashi K, Otsuka M, Nishiwaki H, Senoo T, Ishii T, Sakane G, Sugiura M, Tamura H.  New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines  J Agric Food Chem  2015  63(50):10856-61  PubMed ID: 26576855   DOI: 10.1021/acs.jafc.5b05229
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4991  Tsubaki M, Ogawa N, Takeda T, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Satou T, Nishida S.  Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP.  Biomed Pharmacother  2014  68(8):999-1005  PubMed ID: 25443417   DOI: 10.1016/j.biopha.2014.09.009
5633  Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y.  Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica.  Am J Chin Med  2014  42(5):1245-60  PubMed ID: 25178281   DOI: 10.1142/S0192415X14500785
16548  Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T.  Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities  Chem Biodivers  2014  11(1):73-84  PubMed ID: 24443427   DOI: 10.1002/cbdv.201300266
18791  Nakazaki E, Tsolmon S, Han J, Isoda H.  Proteomic study of granulocytic differentiation induced by apigenin 7-glucoside in human promyelocytic leukemia HL-60 cells  Eur J Nutr  2013  52(1):25-35  PubMed ID: 22113421   DOI: 10.1007/s00394-011-0282-4
19011  Akihisa T, Pan X, Nakamura Y, Kikuchi T, Takahashi N, Matsumoto M, Ogihara E, Fukatsu M, Koike K, Tokuda H.  Limonoids from the fruits of Melia azedarach and their cytotoxic activities  Phytochemistry  2013  89:59-70  PubMed ID: 23465718   DOI: 10.1016/j.phytochem.2013.01.015
19078  Kikuchi T, Pan X, Ishii K, Nakamura Y, Ogihara E, Koike K, Tanaka R, Akihisa T.  Cytotoxic and apoptosis-inducing activities of 12-O-Acetylazedarachin B from the fruits of Melia azedarach in human cancer cell lines  Biol Pharm Bull  2013  36(1):135-9  PubMed ID: 23302647   DOI: 10.1248/bpb.b12-00795
19173  Akihisa T, Kawashima K, Orido M, Akazawa H, Matsumoto M, Yamamoto A, Ogihara E, Fukatsu M, Tokuda H, Fuji J.  Antioxidative and melanogenesis-inhibitory activities of caffeoylquinic acids and other compounds from moxa  Chem Biodivers  2013  10(3):313-27  PubMed ID: 23495149   DOI: 10.1002/cbdv.201200357
19293  Kakiuchi Y, Hirohashi N, Murakami-Murofushi K.  The macroscopic structure of RADA16 peptide hydrogel stimulates monocyte/macrophage differentiation in HL60 cells via cholesterol synthesis  Biochem Biophys Res Commun  2013  433(3):298-304  PubMed ID: 23518074   DOI: 10.1016/j.bbrc.2013.02.105
19298  Nishiura H, Zhao R, Chen J, Taniguchi K, Yamamoto T.  Involvement of regional neutrophil apoptosis promotion by ribosomal protein S19 oligomers in resolution of experimental acute inflammation  Pathol Int  2013  63(12):581-90  PubMed ID: 24422954   DOI: 10.1111/pin.12115
4990  Ukiya M, Kawaguchi T, Ishii K, Ogihara E, Tachi Y, Kurita M, Ezaki Y, Fukatsu M, Kushi Y, Akihisa T.  Cytotoxic activities of amino acid-conjugate derivatives of abietane-type diterpenoids against human cancer cell lines.  Chem Biodivers  2013  10(7):1260-8  PubMed ID: 23847070   DOI: 10.1002/cbdv.201300043
4993  Tsubaki M, Itoh T, Satou T, Imano M, Komai M, Ogawa N, Mukai J, Nishida S.  Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.  Biochem Pharmacol  2013  85(2):163-72  PubMed ID: 23085435   DOI: 10.1016/j.bcp.2012.10.009
5329  Miyoshi N, Iwasaki N, Tomono S, Higashi T, Ohshima H.  Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.  Free Radic Biol Med  2013  60:73-9  PubMed ID: 23395781   DOI: 10.1016/j.freeradbiomed.2013.01.029
5631  Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.  Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines.  Int J Mol Sci  2013  14(2):4106-20  PubMed ID: 23429195   DOI: 10.3390/ijms14024106
5110  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061  
6069  Koh T, Machino M, Murakami Y, Umemura N, Sakagami H.  Cytotoxicity of dental compounds towards human oral squamous cell carcinoma and normal oral cells.  In Vivo  2013  27(1):85-95  PubMed ID: 23239856  
6085  Monzen S, Takimura K, Kashiwakura I, Hosokawa Y.  Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate.  Leuk Res  2013  37(9):1162-9  PubMed ID: 23773897   DOI: 10.1016/j.leukres.2013.04.027
9097  Masahiro Nagahama, Masahiro Shibutani, Soshi Seike, Mami Yonezaki, Teruhisa Takagishi, Masataka Oda, Keiko Kobayashi, Jun Sakurai  The p38 MAPK and JNK Pathways Protect Host Cells Against Clostridium Perfringens Beta-Toxin  Infect Immun  2013  81 (10), 3703-8  PubMed ID: 23876806   DOI: 10.1128/IAI.00579-13
15768  Yamasaki M, Motonaga C, Yokoyama M, Ikezaki A, Kakihara T, Hayasegawa R, Yamasaki K, Sakono M, Sakakibara Y, Suiko M, Nishiyama K.  Induction of apoptotic cell death in HL-60 cells by jacaranda seed oil derived fatty acids  J Oleo Sci  2013  62(11):925-32  PubMed ID: 24200941   DOI: 10.5650/jos.62.925
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17158  Zhu JS, Nakagawa S, Chen W, Adachi I, Jia YM, Hu XG, Fleet GW, Wilson FX, Nitoda T, Horne G, van Well R, Kato A, Yu CY.  Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases  J Org Chem  2013  78(20):10298-309  PubMed ID: 24032658   DOI: 10.1021/jo401694e
18271  Matsumoto T, Jimi S, Hara S, Takamatsu Y, Suzumiya J, Tamura K.  Importance of inducible multidrug resistance 1 expression in HL-60 cells resistant to gemtuzumab ozogamicin  Leuk Lymphoma  2012  53(7):1399-405  PubMed ID: 22242821   DOI: 10.3109/10428194.2012.656102
18587  Akihisa T, Takeda A, Akazawa H, Kikuchi T, Yokokawa S, Ukiya M, Fukatsu M, Watanabe K.  Melanogenesis-inhibitory and cytotoxic activities of diarylheptanoids from Acer nikoense bark and their derivatives  Chem Biodivers  2012  9(8):1475-89  PubMed ID: 22899608   DOI: 10.1002/cbdv.201200024
18794  Akihisa T, Motoi T, Seki A, Kikuchi T, Fukatsu M, Tokuda H, Suzuki N, Kimura Y.  Cytotoxic activities and anti-tumor-promoting effects of microbial transformation products of prenylated chalcones from Angelica keiskei  Chem Biodivers  2012  9(2):318-30  PubMed ID: 22344908   DOI: 10.1002/cbdv.201100255
19182  Nagashima H, Nakagawa H, Kushiro M.  Opposite effects of two trichothecene mycotoxins, deoxynivalenol and nivalenol, on the levels of macrophage inflammatory protein (MIP)-1α and MIP-1β in HL60 cells  Environ Toxicol Pharmacol  2012  34(3):1014-7  PubMed ID: 22964157   DOI: 10.1016/j.etap.2012.07.008
19290  Hazawa M, Hosokawa Y, Monzen S, Yoshino H, Kashiwakura I.  Regulation of DNA damage response and cell cycle in radiation-resistant HL60 myeloid leukemia cells  Oncol Rep  2012  28(1):55-61  PubMed ID: 22576796   DOI: 10.3892/or.2012.1771
19296  Kok YY, Mooi LY, Ahmad K, Sukari MA, Mat N, Rahmani M, Ali AM.  Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S  Molecules  2012  17(4):4651-60.  PubMed ID: 22522395   DOI: 10.3390/molecules17044651
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19301  Palimkar SS, Uenishi J, Ii H.  Total synthesis and biological evaluation of (-)-apicularen A and its analogues  J Org Chem  2012  ;77(1):388-99  PubMed ID: 22118352   DOI: 10.1021/jo2019762
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16550  Yamasaki M, Kawabe A, Nishimoto K, Madhyastha H, Sakakibara Y, Suiko M, Okamoto T, Suda T, Uehira K, Nishiyama K.  Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid  In Vitro Cell Dev Biol Anim  2009  45(5-6):275-80  PubMed ID: 19118438   DOI: 10.1007/s11626-008-9164-3
16890  Ryo-taro Yamaguchi, Ayumi Hirano-Iwata, Yasuo Kimura, Michio Niwano, Ko-ichiro Miyamoto, Hiroko Isoda, Hitoshi Miyazaki  In situ real-time monitoring of apoptosis on leukemia cells by surface infrared spectroscopy  Journal of Applied Physics  2009  105:024701    DOI: 10.1063/1.3068203
18306  Kong D, Aoki S, Sowa Y, Sakai T, Kobayashi M.  Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells  Mar Drugs  2008  6(3):480-8  PubMed ID: 19005580   DOI: 10.3390/md20080023
18319  Kanemura N, Tsurumi H, Okuno M, Matsushima-Nishiwaki R, Shimizu M, Moriwaki H.  Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells  Leuk Res  2008  32(6):884-92  PubMed ID: 18082883   DOI: 10.1016/j.leukres.2007.11.005
19285  Hitoshi Nagashima, Hiroyuki Nakagawa, Keiko Iwashita  Mycotoxin Nivalenol Induces Apoptosis and Intracellular Calcium Ion-Dependent Interleukin-8 Secretion but Does Not Exert Mutagenicity  Animal Cell Technology: Basic & Applied Aspects  2008  301-306    DOI: 10.1007/978-1-4020-9646-4_46
19287  Fujikawa Y, Urano Y, Komatsu T, Hanaoka K, Kojima H, Terai T, Inoue H, Nagano T.  Design and synthesis of highly sensitive fluorogenic substrates for glutathione S-transferase and application for activity imaging in living cells  J Am Chem Soc  2008  130(44):14533-43  PubMed ID: 18841967   DOI: 10.1021/ja802423n
3900  Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E.  Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis.  Anticancer Res  2008  28(2B):1169-79  PubMed ID: 18505053  
9130  Tomohiro Itoh, Yuko Ito, Kenji Ohguchi, Masayoshi Ohyama, Munekazu Iinuma, Yoshinori Otsuki, Yoshinori Nozawa, Yukihiro Akao  Eupalinin A Isolated From Eupatorium Chinense L. Induces Autophagocytosis in Human Leukemia HL60 Cells  Bioorg Med Chem  2008  16 (2), 721-31  PubMed ID: 17980607   DOI: 10.1016/j.bmc.2007.10.033
16549  Yumita N, Han QS, Kitazumi I, Umemura S.  Sonodynamically-induced apoptosis, necrosis, and active oxygen generation by mono-l-aspartyl chlorin e6  Cancer Sci  2008  99(1):166-72  PubMed ID: 17970784   DOI: 10.1111/j.1349-7006.2007.00653.x
18167  Jun-ichi Kitagawa, Takeshi Hara, Hisashi Tsurumi, Nobuhiro Kanemura, Masahito Shimizu, Hisataka Moriwai  Priming Effect with G-CSF Enhances In Vitro Apoptosis by Treatment with Ara-C and VP-16 in Leukemic Cell Line  Blood  2007  110:4333-4333    DOI: 10.1182/blood.v110.11.4333.4333
8814  Roy MK, Nakahara K, Na TV, Trakoontivakorn G, Takenaka M, Isobe S, Tsushida T.  Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis.  Pharmazie  2007  62:149-53  PubMed ID: 17341037  
18606  Nagasawa M, Nakagawa Y, Tanaka S, Kojima I.  Chemotactic peptide fMetLeuPhe induces translocation of the TRPV2 channel in macrophages  J Cell Physiol  2007  210(3):692-702  PubMed ID: 17154364   DOI: 10.1002/jcp.20883
18790  Efdi M, Itoh T, Akao Y, Nozawa Y, Koketsu M, Ishihara H.  The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium  Bioorg Med Chem  2007  15(11):3667-71  PubMed ID: 17400462   DOI: 10.1016/j.bmc.2007.03.051
18909  Ryo-taro Yamaguchi, Ayumi Hirano-Iwata, Yasuo Kimura, Michio Niwano, Ko-ichiro Miyamoto, Hiroko Isoda, Hitoshi Miyazaki  Real-time monitoring of cell death by surface infrared spectroscopy  Applied Physics Letters  2007  91    DOI: 10.1063/1.2813013
18976  Kurata R, Adachi M, Yamakawa O, Yoshimoto M.  Growth suppression of human cancer cells by polyphenolics from sweetpotato (Ipomoea batatas L.) leaves  J Agric Food Chem  2007  55(1):185-90  PubMed ID: 17199331   DOI: 10.1021/jf0620259
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725   DOI: 10.1021/np0604681
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453   DOI: 10.1111/j.1365-2672.2006.03260.x
13871  Jimi S, Mashima K, Matsumoto T, Hara S, Suzumiya J, Tamura K.  RARalpha is a regulatory factor for Am-80-induced cell growth inhibition of hematologic malignant cells  Int J Oncol  2007  31(2):397-404  PubMed ID: 17611697  
15555  Takehito Suzuki, Setsuo Ushikoshi, Hidetoshi Morita, Hideo Fukuoka  Aqueous Extracts of Rhizopus oryzae Induce Apoptosis in Human Promyelocytic Leukemia Cell Line HL-60  Journal of Health Science  2007  53:760-765    DOI: 10.1248/jhs.53.760
18792  Suzuki T, Tazoe H, Taguchi K, Koyama Y, Ichikawa H, Hayakawa S, Munakata H, Isemura M.  DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells  Biomed Res  2006  27(3):99-109  PubMed ID: 16847355   DOI: 10.2220/biomedres.27.99
19142  Yamaguchi T, Saneyoshi M, Takahashi H, Hirokawa S, Amano R, Liu X, Inomata M, Maruyama T.  Synthetic nucleosides and nucleotides. 43. Inhibition of vertebrate telomerases by carbocyclic oxetanocin g (C.OXT-G) triphosphate analogues and influence of C.OXT-G treatment on telomere length in human HL60 cells  Nucleosides Nucleotides Nucleic Acids  2006  25(4-6):539-51  PubMed ID: 16838844   DOI: 10.1080/15257770600684217
3583  Tomoyuki Mochida Reiko Torigoe Takeo Koinuma Chika Asano Tadaaki Satou Kazuo Koike Tamotsu Nikaido  Platinum-Group Chelate Complexes with 9-Hydroxyphenalenone Derivatives:Synthesis, Structures, Spectroscopic Properties and Cytotoxic Activities  Eur J Inorg Chem   2006  558–565    DOI: 10.1002/ejic.200500778
17370  F. W. YIP, Y. FARINA, S. G. TEOH, S. H. INAYAT-HUSSAIN, BOHARI M. YAMIN, I. BABA AND A. M. ALI  EFFECT OF ADDITIONAL METHYLENE GROUPS OF TRIPHENYLTIN(IV) COMPLEX DERIVATIVES OF DICARBOXYLIC ACIDS ON CYTOTOXICITY TESTS ON HUMAN PROMYELOCYTIC LEUKEMIC CELLS AND 119Sn NMR RESONANCE  Malaysian Journal of Pharmaceutical Sciences  2006  4:33-47   
17380  Hitoshi NAGASHIMA, Hiroyuki NAKAGAWA and Keiko IWASHITA  Cytotoxic effects of nivalenol on HL60 cells  Mycotoxins  2006  56:65-70   
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294   DOI: 10.1093/jb/mvi177
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879   DOI: 10.1093/jb/mvi003
3391  Matsumoto, Yoko, Iwamoto, Yasunori, Matsushita, Taku, Ueoka, Ryuichi  Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.  Int J Cancer  2005  115:377-82  PubMed ID: 15700314   DOI: 10.1002/ijc.20882
3071  Suzuki, Takuji, Koyama, Yu, Ichikawa, Hiroyasu, Tsushima, Koji, Abe, Kouichi, Hayakawa, Sumio, Kuruto-Niwa, Ryoko, Nozawa, Ryushi, Isemura, Mamoru  1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells  Cell Struct Funct  2005  30:1-6  PubMed ID: 15951637   DOI: 10.1247/csf.30.1
18635  Hong J, Ishihara K, Zee O, Ohuchi K.  Induction of apoptosis by apicularen A in human promyelocytic leukemia cell line HL-60  Planta Med  2005  71(4):306-12  PubMed ID: 15856405   DOI: 10.1055/s-2005-864095
19286  Satou T, Horiuchi A, Akao N, Koike K, Fujita K, Nikaido T.  Toxocara canis: search for a potential drug amongst beta-carboline alkaloids--in vitro and mouse studies  Exp Parasitol  2005  110(2):134-9.  PubMed ID: 15888295   DOI: 10.1016/j.exppara.2005.02.006
6875  Atsumi T, Murakami Y, Shibuya K, Tonosaki K, Fujisawa S.  Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol.  Anticancer Res  2005  25(6B):4029-36  PubMed ID: 16309195  
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
9186  Risa Takeuchi, Hiroshi Hoshijima, Noriko Onuki, Hiroshi Nagasaka, Shahead Ali Chowdhury, Masami Kawase, Hiroshi Sakagami  Effect of Anticancer Agents on Codeinone-Induced Apoptosis in Human Cancer Cell Lines  Anticancer Res  2005  25 (6B), 4037-41  PubMed ID: 16309196  
15551  Hirohisa Matsushita, Hiroaki Kuwabara, Satoko Ishikawa, Masataka Mochizuki  Apoptosis Induced in Human Cell Lines by a Butanol Extract from Chlorophytum comosum Roots  Journal of Health Science  2005  51:341-345    DOI: 10.1248/jhs.51.341
15612  Yuko Yoshizawa, Kenji Sakurai, Satoru Kawaii, Masayoshi Asari, Junichi Soejima, Noboru Murofushi  Comparison of Antiproliferative and Antioxidant Properties among Nineteen Apple Cultivars  HortScience  2005  40:1204-1207    DOI: 10.21273/hortsci.40.5.1204
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16806  Wei Li, Yoshihisa Asada, Kazuo Koike, Tamotsu Nikaido, Tsutomu Furuya, Takafumi Yoshikawa  Bellisosides A–F, six novel acylated triterpenoid saponins from Bellis perennis (compositae)  Tetrahedron  2005  61:2921-2929    DOI: 10.1016/j.tet.2005.01.026
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2924  Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Inagaki C  Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells.  Eur J Pharmacol  2004  488:27-34  PubMed ID: 15044032   DOI: 10.1016/j.ejphar.2004.02.008
2670  Yamaguchi, Noboru, Kubo, Chie, Masuhiro, Yoshikazu, Lally, Edward T, Koga, Toshihiko, Hanazawa, Shigemasa  Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.  Infect Immun  2004  72:269-76  PubMed ID: 14688105   DOI: 10.1128/iai.72.1.269-276.2004
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2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424   DOI: 10.1074/jbc.M401881200
18735  Roy MK, Thalang VN, Trakoontivakorn G, Nakahara K.  Mechanism of mahanine-induced apoptosis in human leukemia cells (HL-60)  Biochem Pharmacol  2004  67(1):41-51  PubMed ID: 14667927   DOI: 10.1016/j.bcp.2003.07.021
6738  Kawaii S, Lansky EP  Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.  J Med Food  2004  7(1):13-8  PubMed ID: 15117547   DOI: 10.1089/109662004322984644
15689  Yuko YOSHIZAWA, Kenji SAKURAI, Satoru KAWAII, Junichi SOEJIMA, Noboru MUROFUSHI  Antiproliferative and Antioxidant Properties of Crabapple Juices  Food Science and Technology Research  2004  10:278-281    DOI: 10.3136/fstr.10.278
2968  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1132-5  PubMed ID: 12834294   DOI: 10.1271/bbb.67.1132
2969  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1836-9  PubMed ID: 12951526   DOI: 10.1271/bbb.67.1836
18643  Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, Yamauchi K, Hashizume K.  The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells  J Biol Chem  2003  278(51):51685-92  PubMed ID: 14530287   DOI: 10.1074/jbc.M308016200
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2516  Yamaguchi T, Okada T, Takeuchi K, Tonda T, Ohtaki M, Shinoda S, Masuzawa T, Ozawa K, Inaba T.  Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.  Gene Ther  2003  10(5):375-85  PubMed ID: 12601392   DOI: 10.1038/sj.gt.3301897
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15544  MAKOTO NOGUCHI, ICHIRO ARIFUKU, AKIMICHI YAMASHITA, KENZO SATO  Induction of hepatocyte growth factor and inhibition of proliferationby extracellular matrix component derived from fish skin of Reinhararditushippoglossoides  Fisheries Science  2003  69:401-407    DOI: 10.1046/j.1444-2906.2003.00635.x
17300  Hong J, Ishihara K, Yamaki K, Hiraizumi K, Ohno T, Ahn JW, Zee O, Ohuchi K.  Apicidin, a histone deacetylase inhibitor, induces differentiation of HL-60 cells  Cancer Lett  2003  189(2):197-206  PubMed ID: 12490313   DOI: 10.1016/s0304-3835(02)00500-1
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2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539   DOI: 10.1248/bpb.25.383
18722  Nakahara K, Trakoontivakorn G, Alzoreky NS, Ono H, Onishi-Kameyama M, Yoshida M.  Antimutagenicity of some edible Thai plants, and a bioactive carbazole alkaloid, mahanine, isolated from Micromelum minutum  J Agric Food Chem  2002  50(17):4796-802  PubMed ID: 12166962   DOI: 10.1021/jf025564w
18902  Kondo T, Suzuki Y, Kitano T, Iwai K, Watanabe M, Umehara H, Daido N, Domae N, Tashima M, Uchiyama T, Okazaki T.  Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis  Mol Pharmacol  2002  61(3):620-7  PubMed ID: 11854443   DOI: 10.1124/mol.61.3.620
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2965  Kohda A, Taguchi H, Okumura K  Visualization of biallelic expression of the imprinted SNRPN gene induced by inhibitors of DNA methylation and histone deacetylation.  Biosci Biotechnol Biochem  2001  65:1236-9  PubMed ID: 11440148   DOI: 10.1271/bbb.65.1236
2966  Kohda A, Taguchi H, Okumura K  Preparation of extended metaphase chromosomes from human cultured cells using a topoisomerase II inhibitor, ICRF-193.  Biosci Biotechnol Biochem  2001  65:1248-51  PubMed ID: 11440151   DOI: 10.1271/bbb.65.1248
2550  Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62  PubMed ID: 11725959   DOI: 10.1248/bpb.24.1258
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16909  Nagashima H, Nakamura K, Goto T.  Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells.  Biochem Biophys Res Commun  2001  287(4):287(4)  PubMed ID: 11573937   DOI: 10.1006/bbrc.2001.5657
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