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Cell No. : Cell Name
RCB0041 : HL60  update : 2020/09/24
CommentDifferentiate to granulocytes and monocytes
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, a prior written permission of the DEPOSITOR or the RIKEN BRC is necessary.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Ohno, Tadao
Year of deposit 1986
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Tissue blood
Case history promyelocytic leukemia
Classification cancer
History Tokyo Uni.
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 44-175(50) : 44(8),45(15),46(4),87(1),88(6)/
Images
deposit info
lot info
Reference information Reference 7
User's Publication 108


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Reference
1468  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  A Gene Coding for a Zinc Finger Protein Is Induced during 12-O-Tetradecanoylphorbol-13-Acetate-Stimulated HL-60 Cell Differentiation  J Biochem  1992  111:272-277  PubMed ID: 1569051
1467  Oguro K, Sakamoto K, Kitajima K, Oda T, Hirano T, Shimizu N, Utiyama H  Determination of Transcriptional Activities of Typical Gene Promoters in HL-60  J Biochem  1992  111:103-108  PubMed ID: 1607356
1466  Shimizu N, Ohta M, Fujiwara C, Sagara J, Mochizuki N, Oda T, Utiyama H  Expression of a novel immediate early gene during 12-O-tetradecanoylphorbol-13-acetate-induced macrophagic differentiation of HL-60 cells.  J Biol Chem  1991  266:12157-61  PubMed ID: 2061303
2033  Drexler, H G, Otsuka K, Gaedicke G, Minowada J  Changes in isoenzyme profiles during induction of differentiation in human myelomonocytic leukemia cell lines.  Cancer Res  1986  46:6078-82  PubMed ID: 2946400
5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  83(20):7898-902  PubMed ID: 3464004
697  Hozumi M  Established leukemia cell lines: their role in the understanding and control of leukemia proliferation.  Crit Rev Oncol Hematol  1985  3:235-77  PubMed ID: 3899390
973  Collins, S J, Gallo, R C, Gallagher, R E  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture.  Nature  1977  270:347-9  PubMed ID: 271272

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User's Publication
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
11329  Umehara T, Mori R, Mace KA, Murase T, Abe Y, Yamamoto T, Ikematsu K.  Identification of Specific miRNAs in Neutrophils of Type 2 Diabetic Mice: Overexpression of miRNA-129-2-3p Accelerates Diabetic Wound Healing.  Diabetes  2019    PubMed ID: 30523028
11627  Kawashima H, Toyooka N, Okada T, Nguyen HD, Nishikawa Y, Miura Y, Inoue N, Kimura KI.  Identification and Total Synthesis of Two Previously Unreported Odd-Chain Bis-Methylene-Interrupted Fatty Acids with a Terminal Olefin that Activate Protein Phosphatase, Mg2+/Mn2+-Dependent 1A (PPM1A) in Ovaries of the Limpet Cellana toreuma.  Mar Drugs  2019    PubMed ID: 31336763
11652  Tomoki Nakamura, Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Takako Aboshi, Tetsuya Murayama, Ari Widiyantoro, Rikhsan Kurniatuhadi, Abdul Malik, Suwardi Annas, Desi Harneti, Rani Maharani, Unang Supratman, Junpei Abe, Naoaki Kurisawa, Ken-ich Kimura, Yoshihito Shiono  Meroterpenoids produced by Pseudocosmospora sp. Bm-1-1 isolated from Acanthus ebracteatus Vahl  Phytochemistry Letters  2019   
11712  Shota Uesugi, Yuna Honmura, Mami Nishiyama, Kazuaki Kusakabe, Akio Tonouchi, Tetsuro Yamashita, Masaru Hashimoto, Ken-ichi Kimura  Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors  Bioorganic & Medicinal Chemistry  2019    PubMed ID: 31732281
6943  Yamamoto M, Matsumura R, Hirata Y, Nagamune H.  A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods.  Toxicol In Vitro  2019  54:75-81  PubMed ID: 30240708
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478
10497  Tchoukoua A, Kuiate Tabopda T, Konga Simo I, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Shiono Y, Ngadjui BT.  Albidosides H and I, two new triterpene saponins from the barks of Acacia albida Del. (Mimosaceae).  Nat. Prod. Res.  2018  32:924-932  PubMed ID: 28868920
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040
10778  Monzen S, Chiba M, Ueno T, Morino Y, Terada K, Yamaya H, Hosokawa Y.  A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression.  Oncol Lett  2018  15:6709-6714  PubMed ID: 29616132
10799  Kawai C, Yamauchi A, Kuribayashi F.  Monoclonal antibody 7D5 recognizes the R147 epitope on the gp91phox , phagocyte flavocytochrome b558 large subunit.  Microbiol. Immunol.  2018  62:269-280  PubMed ID: 29573449
11008    New Triterpene saponins from the stem of Acacia kamerunensis (Mimosaceae)  Phytochemistry Letters  2018  23, 21-25 
11119  Tanimura A, Miyoshi K, Horiguchi T, Hagita H, Fujisawa K, Noma T.  Mitochondrial Activity and Unfolded Protein Response are Required for Neutrophil Differentiation.  Cell. Physiol. Biochem.  2018  47(5):1936-1950  PubMed ID: 29972819
6831  de Kerckhove M, Tanaka K, Umehara T, Okamoto M, Kanematsu S, Hayashi H, Yano H, Nishiura S, Tooyama S, Matsubayashi Y, Komatsu T, Park S, Okada Y, Takahashi R, Kawano Y, Hanawa T, Iwasaki K, Nozaki T, Torigoe H, Ikematsu K, Suzuki Y, Tanaka K, Martin P, Shimokawa I, Mori R.  Targeting miR-223 in neutrophils enhances the?clearance of Staphylococcus aureus in infected?wounds.  EMBO Mol Med  2018    PubMed ID: 30171089
6902  Kozako T, Mellini P, Ohsugi T, Aikawa A, Uchida YI, Honda SI, Suzuki T.  Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines.  BMC Cancer  2018    PubMed ID: 30081901
4095    Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues  RSC Adv  2018  8, 36895-36902 
4229  Ariefta NR, Kristiana P, Aboshi T, Murayama T, Tawaraya K, Koseki T, Kurisawa N, Kimura KI, Shiono Y.  New isocoumarins, naphthoquinones, and a cleistanthane-type diterpene from Nectria pseudotrichia 120-1NP.  Fitoterapia  2018    PubMed ID: 29621598
4230  Okimura C, Sakumura Y, Shimabukuro K, Iwadate Y.  Sensing of substratum rigidity and directional migration by fast-crawling cells.  Phys Rev E  2018    PubMed ID: 29906928
10047  Tchoukoua A, Tabopda TK, Uesugi S, Ohno M, Kimura KI, Kwon E, Momma H, Horo I, Çalişkan ÖA, Shiono Y, Ngadjui BT.  Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).  Phytochemistry  2017  136:31-38  PubMed ID: 28043655
10126  Yoshida J, Uesugi S, Kawamura T, Kimura KI, Hu D, Xia S, Toyooka N, Ohnishi M, Kawashima H.  (4Z,15Z)-Octadecadienoic Acid Inhibits Glycogen Synthase Kinase-3β and Glucose Production in H4IIE Cells.  Lipids  2017  52:295-301  PubMed ID: 28194557
10267  Tsunaka M, Shinki H, Koyama T.  Cell-based evaluation of changes in coagulation activity induced by antineoplastic drugs for the treatment of acute myeloid leukemia.  PLoS ONE  2017  12:e0175765  PubMed ID: 28406995
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165
10483  Mukai M, Suruga N, Saeki N, Ogawa K.  EphA receptors and ephrin-A ligands are upregulated by monocytic differentiation/maturation and promote cell adhesion and protrusion formation in HL60 monocytes.  BMC Cell Biol.  2017  18:28  PubMed ID: 28851287
10907  Hosokawa Y, Saga R, Monzen S, Terashima S, Tsuruga E.  Ascorbic acid does not reduce the anticancer effect of radiotherapy  Biomed Rep  2017  6:103-107  PubMed ID: 28123717
9126  Abdou Tchoukoua, Turibio Kuiate Tabopda, Narandulam Usukhbayar, Ken-Ichi Kimura, Eunsang Kwon, Hiroyuki Momma, Takuya Koseki, Yoshihito Shiono, Bonaventure Tchaleu Ngadjui   New Triterpene Saponins From the Roots of Acacia Macrostachya (Mimosaceae)  Biosci Biotechnol Biochem  2017  81 (12), 2261-2267  PubMed ID: 29052455
7093  Monzen S, Chiba M, Hosokawa Y.  Genetic network profiles associated with established resistance to ionizing radiation in acute promyelocytic leukemia cells and their extracellular vesicles.  Oncol. Rep.  2016  35:749-56  PubMed ID: 26718911
10882    Yeast Ca2 +-signal transduction inhibitors isolated from Dominican amber prevent the degranulation of RBL-2H3 cells through the inhibition of Ca2 +-influx  Fitoterapia  2016  113, 188-194  PubMed ID: 27491756
7138  Nagashima H.  Rubratoxin-B-induced secretion of chemokine ligands of cysteine-cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells.  Environ. Toxicol. Pharmacol.  2015  40:997-1000  PubMed ID: 26595743
7166  Uesugi S, Fujisawa N, Yoshida J, Watanabe M, Dan S, Yamori T, Shiono Y, Kimura K.  Pyrrocidine A, a metabolite of endophytic fungi, has a potent apoptosis-inducing activity against HL60 cells through caspase activation via the Michael addition.  J. Antibiot.  2015  69:133-40  PubMed ID: 26506860
7568  Tung NH, Uto T, Morinaga O, Shoyama Y  Chemical Constituents from the Aerial Parts of Bupleurum falcatum L. and Biological Evidences.  Natural Product Sciences  2015  21:71-75 
4991  Tsubaki M, Ogawa N, Takeda T, Sakamoto K, Shimaoka H, Fujita A, Itoh T, Imano M, Satou T, Nishida S.  Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP.  Biomed Pharmacother  2014  68(8):999-1005  PubMed ID: 25443417
4993  Tsubaki M, Itoh T, Satou T, Imano M, Komai M, Ogawa N, Mukai J, Nishida S.  Nitrogen-containing bisphosphonates induce apoptosis of hematopoietic tumor cells via inhibition of Ras signaling pathways and Bim-mediated activation of the intrinsic apoptotic pathway.  Biochem Pharmacol  2013  85(2):163-72  PubMed ID: 23085435
5329  Miyoshi N, Iwasaki N, Tomono S, Higashi T, Ohshima H.  Occurrence of cytotoxic 9-oxononanoyl secosterol aldehydes in human low-density lipoprotein.  Free Radic Biol Med  2013  60:73-9  PubMed ID: 23395781
5631  Uto T, Sakamoto A, Tung NH, Fujiki T, Kishihara K, Oiso S, Kariyazono H, Morinaga O, Shoyama Y.  Anti-Proliferative Activities and Apoptosis Induction by Triterpenes Derived from Eriobotrya japonica in Human Leukemia Cell Lines.  Int J Mol Sci  2013  14(2):4106-20  PubMed ID: 23429195
6085  Monzen S, Takimura K, Kashiwakura I, Hosokawa Y.  Acute promyelocytic leukemia mutated to radioresistance suppressed monocyte lineage differentiation by phorbol 12-myristate 13-acetate.  Leuk Res  2013  37(9):1162-9  PubMed ID: 23773897
7690  Abe N, Abe H, Nagai C, Harada M, Hatakeyama H, Harashima H, Ohshiro T, Nishihara M, Furukawa K, Maeda M, Tsuneda S, Ito Y.  Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference.  Bioconjug. Chem.  2011  22:2082-92  PubMed ID: 21899349
7741  Nagashima H, Kushiro M, Nakagawa H.  Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.  Environ. Toxicol. Pharmacol.  2011  31:258-61  PubMed ID: 21787693
7829  Shoji K, Tsubaki M, Yamazoe Y, Satou T, Itoh T, Kidera Y, Tanimori Y, Yanae M, Matsuda H, Taga A, Nakamura H, Nishida S.  Mangiferin induces apoptosis by suppressing Bcl-xL and XIAP expressions and nuclear entry of NF-κB in HL-60 cells.  Arch. Pharm. Res.  2011  34:469-75  PubMed ID: 21547680
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202
8307  Okada M, Nadanaka S, Shoji N, Tamura J, Kitagawa H.  Biosynthesis of heparan sulfate in EXT1-deficient cells.  Biochem. J.  2010  428:463-71  PubMed ID: 20377530
8340  Aburai N, Yoshida M, Ohnishi M, Kimura K.  Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells.  Biosci. Biotechnol. Biochem.  2010  74:548-52  PubMed ID: 20208361
8362  Aburai N, Yoshida M, Ohnishi M, Kimura K.  Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.  Phytomedicine  2010  17:782-8  PubMed ID: 20153620
4869  Kitagawa J, Hara T, Tsurumi H, Kanemura N, Kasahara S, Shimizu M, Moriwaki H.  Cell cycle-dependent priming action of granulocyte colony-stimulating factor (G-CSF) enhances in vitro apoptosis induction by cytarabine and etoposide in leukemia cell lines.  J Clin Exp Hematop  2010  50(2):99-105  PubMed ID: 21123967
9080  Akihiro Unno, Katsuya Kitoh, Yasuhiro Takashima  Up-regulation of Hyaluronan Receptors in Toxoplasma Gondii-Infected Monocytic Cells  Biochem Biophys Res Commun  2010  391 (1), 477-80  PubMed ID: 19914206
8461  Tokiwano T, Satoh H, Obara T, Hirota H, Yoshizawa Y, Yamamoto Y.  A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.  Biosci. Biotechnol. Biochem.  2009  73:2525-7  PubMed ID: 19897905
8582  Zhang G, Wu H, Zhu B, Shimoishi Y, Nakamura Y, Murata Y.  Induction of apoptosis by beta-carotene and dimethyl tetrasulfide assisted by UVA irradiation in HL-60 cells.  Biosci. Biotechnol. Biochem.  2009  73:1014-20  PubMed ID: 19420723
8603  Furukawa K, Abe H, Hibino K, Sako Y, Tsuneda S, Ito Y.  Reduction-triggered fluorescent amplification probe for the detection of endogenous RNAs in living human cells.  Bioconjug. Chem.  2009  20:1026-36  PubMed ID: 19374406
8615  Matsuda H, Akaki J, Nakamura S, Okazaki Y, Kojima H, Tamesada M, Yoshikawa M.  Apoptosis-inducing effects of sterols from the dried powder of cultured mycelium of Cordyceps sinensis.  Chem. Pharm. Bull.  2009  57:411-4  PubMed ID: 19336939
5419  Saegusa S, Totsuka M, Kaminogawa S, Hosoi T.  Saccharomyces cerevisiae and Candida albicans stimulate cytokine secretion from human neutrophil-like HL-60 cells differentiated with retinoic acid or dimethylsulfoxide.  Biosci Biotechnol Biochem  2009  73(12):2600-8  PubMed ID: 19966493
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360
9187  Tomohiro Itoh, Kenji Ohguchi, Yoshinori Nozawa, Yukihiro Akao  Intracellular Glutathione Regulates Sesquiterpene Lactone-Induced Conversion of Autophagy to Apoptosis in Human Leukemia HL60 Cells  Anticancer Res  2009  29 (4), 1449-57  PubMed ID: 19414401
9130  Tomohiro Itoh, Yuko Ito, Kenji Ohguchi, Masayoshi Ohyama, Munekazu Iinuma, Yoshinori Otsuki, Yoshinori Nozawa, Yukihiro Akao  Eupalinin A Isolated From Eupatorium Chinense L. Induces Autophagocytosis in Human Leukemia HL60 Cells  Bioorg Med Chem  2008  16 (2), 721-31  PubMed ID: 17980607
8814  Roy MK, Nakahara K, Na TV, Trakoontivakorn G, Takenaka M, Isobe S, Tsushida T.  Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis.  Pharmazie  2007  62:149-53  PubMed ID: 17341037
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453
3583  Tomoyuki Mochida Reiko Torigoe Takeo Koinuma Chika Asano Tadaaki Satou Kazuo Koike Tamotsu Nikaido  Platinum-Group Chelate Complexes with 9-Hydroxyphenalenone Derivatives: Synthesis, Structures, Spectroscopic Properties and Cytotoxic Activities  Eur J Inorg Chem   2006  558–565 
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879
3391  Matsumoto, Yoko, Iwamoto, Yasunori, Matsushita, Taku, Ueoka, Ryuichi  Novel mechanism of hybrid liposomes-induced apoptosis in human tumor cells.  Int J Cancer  2005  115:377-82  PubMed ID: 15700314
3071  Suzuki, Takuji, Koyama, Yu, Ichikawa, Hiroyasu, Tsushima, Koji, Abe, Kouichi, Hayakawa, Sumio, Kuruto-Niwa, Ryoko, Nozawa, Ryushi, Isemura, Mamoru  1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells  Cell Struct Funct  2005  30:1-6  PubMed ID: 15951637
6875  Atsumi T, Murakami Y, Shibuya K, Tonosaki K, Fujisawa S.  Induction of cytotoxicity and apoptosis and inhibition of cyclooxygenase-2 gene expression, by curcumin and its analog, alpha-diisoeugenol.  Anticancer Res  2005  25(6B):4029-36  PubMed ID: 16309195
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112
9186  Risa Takeuchi, Hiroshi Hoshijima, Noriko Onuki, Hiroshi Nagasaka, Shahead Ali Chowdhury, Masami Kawase, Hiroshi Sakagami  Effect of Anticancer Agents on Codeinone-Induced Apoptosis in Human Cancer Cell Lines  Anticancer Res  2005  25 (6B), 4037-41  PubMed ID: 16309196
2905  Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Sumita K, Inagaki C  Expression and roles of Cl- channel ClC-5 in cell cycles of myeloid cells.  Biochem Biophys Res Commun  2004  317:192-7  PubMed ID: 15047167
2924  Jiang B, Hattori N, Liu B, Nakayama Y, Kitagawa K, Inagaki C  Suppression of cell proliferation with induction of p21 by Cl(-) channel blockers in human leukemic cells.  Eur J Pharmacol  2004  488:27-34  PubMed ID: 15044032
2670  Yamaguchi, Noboru, Kubo, Chie, Masuhiro, Yoshikazu, Lally, Edward T, Koga, Toshihiko, Hanazawa, Shigemasa  Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression.  Infect Immun  2004  72:269-76  PubMed ID: 14688105
3341  Nonaka, Mihoko, Ikeda, Hisazumi, Inokuchi, Tsugio  Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy in vitro.  Photochem Photobiol  2004  79:94-8  PubMed ID: 14982037
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424
2968  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1132-5  PubMed ID: 12834294
2969  Iwata, Keiko, Ogata, Shin, Okumura, Katsuzumi, Taguchi, Hiroshi  Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.  Biosci Biotechnol Biochem  2003  67:1836-9  PubMed ID: 12951526
3979  Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.  Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.  J Nat Prod  2003  66(8):1124-7  PubMed ID: 12932141
2516  Yamaguchi T, Okada T, Takeuchi K, Tonda T, Ohtaki M, Shinoda S, Masuzawa T, Ozawa K, Inaba T.  Enhancement of thymidine kinase-mediated killing of malignant glioma by BimS, a BH3-only cell death activator.  Gene Ther  2003  10(5):375-85  PubMed ID: 12601392
9038  Masahiro Nagahama, Shinya Hayashi, Shinsuke Morimitsu, Jun Sakurai  Biological Activities and Pore Formation of Clostridium Perfringens Beta Toxin in HL 60 Cells  J Biol Chem  2003  278 (38), 36934-41  PubMed ID: 12851396
2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539
2980  Horiguchi-Yamada J et al  An intermediate dose of X-ray irradiation induces apoptosis following G2 arrest in human leukemia HL60 cells  Jikeikai Med.  2001  48:27-38 
2965  Kohda A, Taguchi H, Okumura K  Visualization of biallelic expression of the imprinted SNRPN gene induced by inhibitors of DNA methylation and histone deacetylation.  Biosci Biotechnol Biochem  2001  65:1236-9  PubMed ID: 11440148
2966  Kohda A, Taguchi H, Okumura K  Preparation of extended metaphase chromosomes from human cultured cells using a topoisomerase II inhibitor, ICRF-193.  Biosci Biotechnol Biochem  2001  65:1248-51  PubMed ID: 11440151
2550  Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62  PubMed ID: 11725959
2967  Ogata S, Inoue K, Iwata K, Okumura K, Taguchi H  Apoptosis induced by picolinic acid-related compounds in HL-60 cells.  Biosci Biotechnol Biochem  2001  65:2337-9  PubMed ID: 11758936
2994  Nogami M, Nogami O, Kagotani K, Okumura M, Taguchi H, Ikemura T, Okumura K  Intranuclear arrangement of human chromosome 12 correlates to large-scale replication domains.  Chromosoma  2000  108:514-22  PubMed ID: 10794573
2960  Ogata S, Takeuchi M, Fujita H, Shibata K, Okumura K, Taguchi H  Apoptosis induced by nicotinamide-related compounds and quinolinic acid in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:327-32  PubMed ID: 10737189
2961  Ogata S, Okumura K, Taguchi H  A simple and rapid method for the detection of poly(ADP-ribose) by flow cytometry.  Biosci Biotechnol Biochem  2000  64:510-5  PubMed ID: 10803947
2964  Nogami M, Kohda A, Taguchi H, Nakao M, Ikemura T, Okumura K  Relative locations of the centromere and imprinted SNRPN gene within chromosome 15 territories during the cell cycle in HL60 cells  J Cell Sci  2000  113:2157-5165  PubMed ID: 10825289
2962  Ogata S, Miyake Y, Yamamoto K, Okumura K, Taguchi H  Apoptosis induced by the flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites in HL-60 cells.  Biosci Biotechnol Biochem  2000  64:1075-8  PubMed ID: 10879486
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