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細胞番号 : 細胞名
RCB0027 : K562  update : 2024/02/19
細胞特性(Comment:英)Human cell line derived from chronic myelogenous leukemia. Can be a target of NK cells (reference). Can produce hemoglobin in the presence of NaB.
細胞特性(日)ヒト慢性骨髄性白血病由来細胞株。NK細胞の標的細胞になる(論文)。NaBの添加によりヘモグロビンを産生する。赤血球への分化が可能。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Kanazawa, Satoshi
樹立者 Lozzio, C.B. & Lozzio, B.B.
寄託日 1986
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Female
53 years
採取組織 pleural effusion
病名 chronic myelogenous leukemia
細胞分類 cancer
細胞寿命 infinite
細胞形態 lymphoblast-like
Cellosaurus(Expasy) CVCL_0004
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Suspension cells
培地 HamF12 + 10% FBS
培養方法 浮遊細胞の培養に関する一般的な注意
抗生物質 Free
継代方法 dilution
継代密度 1 : 10 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
ウィルス(HIV) (-)
ウィルス(HTLV-1) (-)
アイソザイム検査 LD, NP
染色体検査 59-68(50) : /63(5),64(7),65(6),66(8),67(16),68(5)
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 33件
Reference(日) 1件
利用者成果(英) 90件
利用者成果(日) 0件

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Reference(英)
117  Baker EJ, Ichiki AT, Day NE, Andrews RB, Bamberger EG, Lozzio CB.  Simultaneous flow cytometric measurement of K-562 megakaryocytic differentiation and CD56+ large granular lymphocyte cytotoxicity  J Immunol Methods  2001  253(1-2):37-44  PubMed ID: 11384667  
98  Baker EJ, Ichiki AT, Hodge JW, Sugantharaj D, Bamberger EG, Lozzio CB.  PMA-treated K-562 leukemia cells mediate a TH2-specific expansion of CD4+ T cells in vitro  Leuk Res  2000  24(12):1049-57.  PubMed ID: 11077119   DOI: 10.1016/s0145-2126(00)00082-5
97  Ichiki AT, Langenberg M, Baker EJ, Hodge JW, Bamberger EG, Gerard DA, Lozzio CB.  Differential regulation of interleukin-1alpha and interleukin-1beta in K-562 cells  J Interferon Cytokine Res  1998  18(12):1045-50  PubMed ID: 9877448   DOI: 10.1089/jir.1998.18.1045
101  Wust CJ, Hodge JW, Ichiki AT, Lozzio CB.  Cell death in the human leukemia cell line, K-562, induced by antiserum and monoclonal antibodies  Leuk Res  1991  15(6):497-506  PubMed ID: 1713636   DOI: 10.1016/0145-2126(91)90061-w
103  Ichiki AT, Sugantharaj DG, Hudson CS, Gerard DA, Barnhill MA, Bamberger EG, Wust CJ, Fuhr JE, Lozzio CB.  Lowered susceptibility of K-562 cells treated with gamma interferon in serum-free medium to natural killer cell-mediated cytolysis  Nat Immun Cell Growth Regul  1988  7(5-6):297-304  PubMed ID: 3146698  
106  Walter H, Krob EJ, Al-Romaihi FA, Johnson D, Lozzio CB.  Detection of surface differences between closely related cell populations by partitioning. Cultured K-562 cell sublines  Cell Biophys  1988  13(3):173-87  PubMed ID: 2465826   DOI: 10.1007/BF02918374
5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  83(20):7898-902  PubMed ID: 3464004   DOI: 10.1073/pnas.83.20.7898
95  Ichiki AT, Bamberger EG, Wust CJ, Lozzio CB.  Diversity of cell surface hematopoietic antigens on K-562 sublines identified with monoclonal antibodies  Leuk Res  1986  10(5):565-74  PubMed ID: 2940421   DOI: 10.1016/0145-2126(86)90092-5
96  Ichiki AT, Wust CJ, Lozzio CB.  Characterization of the Fc(IgG) receptor on the pluripotential leukaemia cell K-562  Clin Exp Immunol  1985  59(1):64-8  PubMed ID: 3971599  
116  Rowley PT, Ohlsson-Wilhelm BM, Wisniewski L, Lozzio CB, Lozzio BB.  K562 human leukemia cell passages differ in embryonic globin gene expression  Leuk Res  1984  8(1):45-54  PubMed ID: 6199625  
100  Lozzio BB, Machado EA, Mitchell J, Lozzio CB, Wust CJ, Golde DW.  Proliferation of human malignant hematopoietic cells in immunodeficient mice: suppression by antibody to pluripotent K-562 leukemia cells involves direct cytolysis and effector cells  Blood  1983  61(6):1045-53  PubMed ID: 6132631  
94  Wust CJ, Green M, Lozzio CB, Lozzio BB.  Antibody-dependent cytolysis of the human leukemia cell line K-562 in the absence of effector cells or complement  Blood  1982  59(1):133-40  PubMed ID: 7053760  
102  Ichiki AT, Lozzio BB, Wust CJ, Lozzio CB.  Relationship between the Fc receptor for IgG and the specific associated antigen of the pluripotential leukaemia cell line, K-562  Clin Exp Immunol  1982  50(2):360-5  PubMed ID: 6185259  
105  Machado EA, Gerard DA, Mitchell JR, Lozzio BB, Lozzio CB.  Arrest and extravasation of neoplastic cells. An electron microscopy study of serial sections at sequential stages  Virchows Arch A Pathol Anat Histol  1982  396(1):73-89  PubMed ID: 7123846   DOI: 10.1007/BF00428501
107  Lozzio CB, Lozzio BB, Wust CJ, Bamberger EG, Golde DW, Minowada J.  Antibody lysis of human hematopoietic cells in the absence of complement and effector cells  Exp Hematol  1982  10(8):698-707  PubMed ID: 6183138  
115  Perez RL, Mitchell JR, Lozzio BB.  Relevance of lipids to heterotransplantation of human malignancies  Oncology  1982  39(3):179-84  PubMed ID: 7043353   DOI: 10.1159/000225632
87  Lozzio BB, Lozzio CB, Bamberger EG, Feliu AS.  A multipotential leukemia cell line (K-562) of human origin  Proc Soc Exp Biol Med  1981  166(4):546-50  PubMed ID: 7194480   DOI: 10.3181/00379727-166-41106
93  Fuhr JE, Bamberger EG, Lozzio CB, Lozzio BB.  Induction of hemoglobin synthesis in original K 562 cell line  Blood Cells  1981  7(2):389-99  PubMed ID: 6170369  
108  Latif ZA, Lozzio BB, Wust CJ, Krauss S, Aggio MC, Lozzio CB.  Evaluation of drug-antibody conjugates in the treatment of human myelosarcomas transplanted in nude mice  Cancer  1980  45(6):1326-33  PubMed ID: 6928397   DOI: 10.1002/1097-0142(19800315)45:6<1326::aid-cncr2820450610>3.0.co;2-y
113  Lair SV, Lozzio BB.  Thymocyte reconstitution of athymic and athymic-asplenic mice: graft rejection and antibody synthesis  Exp Cell Biol  1980  48(6):439-44  PubMed ID: 6967835   DOI: 10.1159/000163010
4603  Lozzio BB, Lozzio CB.  Properties and usefulness of the original K-562 human myelogenous leukemia cell line.  Leuk Res  1979  3(6):363-70  PubMed ID: 95026   DOI: 10.1016/0145-2126(79)90033-x
969  Rutherford TR, Clegg JB, Weatherall DJ.  K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin.  Nature  1979  280(5718):164-5  PubMed ID: 95354   DOI: 10.1038/280164a0
970  Andersson LC, Jokinen M, Gahmberg CG.  Induction of erythroid differentiation in the human leukaemia cell line K562.  Nature  1979  278(5702):364-5  PubMed ID: 570644   DOI: 10.1038/278364a0
89  Lozzio BB, Machado EA, Lair SV, Lozzio CB.  Reproducible metastatic growth of K-562 human myelogenous leukemia cells in nude mice  J Natl Cancer Inst  1979  63(2):295-9  PubMed ID: 287825  
112  Lozzio CB, Lozzio BB, Wust CJ, Kim J.  Correlation of leukemia-associated antigens and Ph1 chromosome in fibroblastlike cells derived from bone marrow  Blood  1978  52(4):673-80  PubMed ID: 99197  
114  Lozzio BB, Lozzio CB, Bamberger EG.  Cytotoxicity of a factor from normal and abnormal human spleens for allogenic leukemia cells  Am J Hematol  1978  4(1):57-65  PubMed ID: 655158   DOI: 10.1002/ajh.2830040108
99  Collins JL, Wust CJ, Lozzio BB, Lozzio CB.  Characterization of an antigen from the myelogenous leukemia cell line K-562  J Natl Cancer Inst  1977  59(6):1667-74  PubMed ID: 72824   DOI: 10.1093/jnci/59.6.1667
109  Lozzio BB, Lozzio CB, Krauss S, Wust CJ, Girardi A.  Leukemia-associated antigens detected by a nonhuman primate antiserum to a Ph1+ myeologenous leukemia cell line  Blood  1977  50(1):115-24  PubMed ID: 68791  
111  Lozzio BB, Machado EA, Lair SA, Lozzio CB.  Suppression of human myelosarcoma growth in athymic mice by a primate antiserum  Cancer Treat Rep  1977  61(9):1679-84  PubMed ID: 271518  
88  Lozzio CB, Lozzio BB, Yang WK, Ichiki AT, Bamberger EG.  Absence of thymus-derived lymphocyte markers in myelogenous leukemia (Ph1+) cell line K-562  Cancer Res  1976  36(12):4657-62  PubMed ID: 63324  
104  Lozzio BB, Lozzi CB, Machado E.  Human myelogenous (Ph+) leukemia cell line: transplantation into athymic mice  J Natl Cancer Inst  1976  56(3):627-9  PubMed ID: 1062625   DOI: 10.1093/jnci/56.3.627
110  Lozzio BB, Machado EA, Lozzio CB, Lair S.  Hereditary asplenic-athymic mice: transplantation of human myelogenous leukemic cells  J Exp Med  1976  143(1):225-31  PubMed ID: 53268   DOI: 10.1084/jem.143.1.225
4602  Lozzio CB, Lozzio BB.  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.  Blood  1975  45(3):321-34  PubMed ID: 163658  

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Reference(日)
1222  角純子  バイオテクノロジ-素材としての培養細胞 細胞分化(I)  蛋白質 核酸 酵素  1988  33   

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利用者成果(英)
21543  Panyajai P, Viriyaadhammaa N, Tima S, Chiampanichayakul S, Dejkriengkraikul P, Okonogi S, Anuchapreeda S.  Anticancer activity of Curcuma aeroginosa essential oil and its nano-formulations: cytotoxicity, apoptosis and cell migration effects.  BMC Complement Med Ther  2024  24(1):16  PubMed ID: 38166788   DOI: 10.1186/s12906-023-04261-9
18161  Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Nogawa T, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Dohmae N, Osada H.  Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling  Oncol Res  2023  31(6):833-844  PubMed ID: 37744270   DOI: 10.32604/or.2023.030241
19942  Kondo S, Ferdousi F, Zhao J, Suidasari S, Yokozawa M, Yamauchi K, Tominaga KI, Isoda H.  Hematinic Potential of Olive Leaf Extract: Evidence from an In Vivo Study in Mice and a Pilot Study in Healthy Human Volunteers  Nutrients  2023  15(19):4095  PubMed ID: 37836379   DOI: 10.3390/nu15194095
21051  Hirosaki H, Maeda Y, Takeyoshi M.  Establishment of Cell-Based Assay System for Evaluating Cytotoxic Activity Modulated by the Blockade of PD-1 and PD-L1 Interactions with a Therapeutic Antibody.  Immunol Invest  2023  1-11  PubMed ID: 36731129   DOI: 10.1080/08820139.2023.2174442
21352  Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A.  SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine.  Cell Rep  2023  112940  PubMed ID: 37582370   DOI: 10.1016/j.celrep.2023.112940
21375  Tsuchiya M, Tachibana N, Hamachi I.  Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling.  STAR Protoc  2023  4(3):102525  PubMed ID: 37635353   DOI: 10.1016/j.xpro.2023.102525
17569  Hashino T, Matsubara H, Xu J, Tanaka R, Kusagawa E, Ueda Y, Yoshida H, Kataoka T.  PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy  Exp Cell Res  2022  420(1):113342  PubMed ID: 36075447   DOI: 10.1016/j.yexcr.2022.113342
13403  Takeuchi R, Suzuki M, Yasukawa T.  Electrorotation Rates of K562 Cells Accompanied with the Erythroid Differentiation Induced by Sodium Butyrate.  Anal Sci  2021    PubMed ID: 33390466   DOI: 10.2116/analsci.20C017
20082  Yoshimura A, Asahina Y, Chang LY, Angata T, Tanaka H, Kitajima K, Sato C.  Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.  J Biol Chem  2021  100477  PubMed ID: 33640457   DOI: 10.1016/j.jbc.2021.100477
16204  Kondo S, Ferdousi F, Yamauchi K, Suidasari S, Yokozawa M, Harrabi MM, Tominaga KI, Isoda H.  Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells  J Cell Mol Med  2021  25(15):7229-7243  PubMed ID: 34180123   DOI: 10.1111/jcmm.16752
21368  Soboleva S, Kurita R, Ek F, Åkerstrand H, Silvério-Alves R, Olsson R, Nakamura Y, Miharada K.  Identification of potential chemical compounds enhancing generation of enucleated cells from immortalized human erythroid cell lines  Commun Biol2021  2021  4(1):677  PubMed ID: 34083702   DOI: 10.1038/s42003-021-02202-1
13052  Kawai S, Suzuki M, Arimoto S, Korenaga T, Yasukawa T.  Determination of membrane capacitance and cytoplasm conductivity by simultaneous electrorotation.  Analyst  2020    PubMed ID: 32462157   DOI: 10.1039/d0an00100g
13914  Takano M, Higashi M, Baba S, Kawami M, Yumoto R.  Transport of ribavirin in human myelogenous leukemia cell line K562  Pharmazie  2020  75(7):329-334  PubMed ID: 32635975   DOI: 10.1691/ph.2020.0440
14798  Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, Nureki O, Ohmura M, Hayakawa N, Hishiki T, Uchibori R, Ozawa K, Yoshimura A.  The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells  Cancer Res  2020  80(3):471-483  PubMed ID: 31767627   DOI: 10.1158/0008-5472.CAN-19-1196
11537  Miura S, Kobune M, Horiguchi H, Kikuchi S, Iyama S, Murase K, Goto A, Ikeda H, Takada K, Miyanishi K, Kato J.  EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells.  Blood Cells Mol. Dis.  2019    PubMed ID: 31082798   DOI: 10.1016/j.bcmd.2019.04.014
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478   DOI: 10.1038/s41598-019-44817-9
11677  Ryohichi Sugimura, Ryo Ohta, Chihiro Mori, Emi Sano, Tatsuki Sugiyama, Takashi Nagasawa, Akira Niwa,  Angiocrine factors from HUVECs amplify erythroid cells  bioRxiv  2019      DOI: 10.1101/837823
11093  Abdelmoez MN, Iida K, Oguchi Y, Nishikii H, Yokokawa R, Kotera H, Uemura S, Santiago JG, Shintaku H.  SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.  Genome Biol.  2018  19(1):66  PubMed ID: 29871653   DOI: 10.1186/s13059-018-1446-9
4267  Kikuchi G, Kurita R, Ogasawara K, Isa K, Tsuneyama H, Nakamura Y, Yabe R, Shiba M, Tadokoro K, Nagai T, Satake M.  Application of immortalized human erythroid progenitor cell line in serologic tests to detect red blood cell alloantibodies.  Transfusion  2018    PubMed ID: 30180269   DOI: 10.1111/trf.14840
4270  Ichii M, Oritani K, Murase M, Komatsu K, Yamazaki M, Kyoden R, Kito N, Nozaki Y, Saito M, Iwamura H, Kanakura Y.  Molecular targeting of inosine-5'-monophosphate dehydrogenase by FF-10501 promotes erythropoiesis via ROS/MAPK pathway.  Leuk. Lymphoma  2018    PubMed ID: 28730859   DOI: 10.1080/10428194.2017.1339878
4378  Miyauchi M, Koya J, Arai S, Yamazaki S, Honda A, Kataoka K, Yoshimi A, Taoka K, Kumano K, Kurokawa M.  ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells.  Stem Cell Reports  2018  10(3):1115-1130  PubMed ID: 29429960   DOI: 10.1016/j.stemcr.2018.01.015
15049  Ureshino H, Shindo T, Kojima H, Kusunoki Y, Miyazaki Y, Tanaka H, Saji H, Kawaguchi A, Kimura S.  Allelic Polymorphisms of KIR s and HLA s Predict Favorable Responses to Tyrosine Kinase Inhibitors in CML  Cancer Immunol Res  2018  6(6):745-754  PubMed ID: 29695383   DOI: 10.1158/2326-6066.CIR-17-0462
14689  Takagishi T, Takehara M, Seike S, Miyamoto K, Kobayashi K, Nagahama M.  Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation  Sci Rep  2017  7(1):5217  PubMed ID: 28701754   DOI: 10.1038/s41598-017-05567-8
14775  Mahmoud N. Abdelmoez, Kei Iida, Yusuke Oguchi, Hidekazu Nishikii, Ryuji Yokokawa, Hidetoshi Kotera, Sotaro Uemura, Juan G. Santiago, Hirofumi Shintaku  Correlation of gene expressions between nucleus and cytoplasm reflects single-cell physiology  bioRxiv  2017  October 20, 2017    DOI: 10.1101/206672
9546  Nakamura A, Monzen S, Takasugi Y, Wojcik A, Mariya Y.  Application of cell sorting for enhancing the performance of the cytokinesis-block micronucleus assay.  J. Radiat. Res.  2016  57:121-6  PubMed ID: 26826197   DOI: 10.1093/jrr/rrv103
5654  Sadahira Y, Sugihara T, Fujiwara H, Nishimura H, Suetsugu Y, Takeshita M, Okamura S, Goto M.  WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.  Virchows Arch  2015  466(3):343-50  PubMed ID: 25503078   DOI: 10.1007/s00428-014-1703-6
17441  Shimizu K, Shinga J, Yamasaki S, Kawamura M, Dörrie J, Schaft N, Sato Y, Iyoda T, Fujii S.  Transfer of mRNA Encoding Invariant NKT Cell Receptors Imparts Glycolipid Specific Responses to T Cells and γδT Cells  PLoS One  2015  10(6):e0131477  PubMed ID: 26121617   DOI: 10.1371/journal.pone.0131477
13879  Isoda H, Motojima H, Onaga S, Samet I, Villareal MO, Han J.  Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells  Chem Biol Interact  2014  220:269-77  PubMed ID: 25058688   DOI: 10.1016/j.cbi.2014.07.006
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9088  Haiyan Gong, Kyousuke Kobayashi, Tatsuki Sugi, Hitoshi Takemae, Hitomi Kurokawa, Taisuke Horimoto, Hiroomi Akashi, Kentaro Kato  A Novel PAN/apple Domain-Containing Protein From Toxoplasma Gondii: Characterization and Receptor Identification  PLoS One  2012  7 (1), e30169  PubMed ID: 22276154   DOI: 10.1371/journal.pone.0030169
10993  Soninkhishig Tsolmon, Eri Nakazaki, Junkyu Han, Hiroko Isoda  Apigetrin induces erythroid differentiation of human leukemia cells K562: proteomics approach  Mol Nutr Food Res  2011  55 Suppl 1:S93-S102  PubMed ID: 21480518   DOI: 10.1002/mnfr.201000650
12292  Yujiro Tanaka, Koji Kawahashi, Zen-Ichiro Katagiri, Yasuhiro Nakayama, Milind Mahajan, Dimitris Kioussis  Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression  PLoS One  2011  6(11):e28171  PubMed ID: 22140534   DOI: 10.1371/journal.pone.0028171
18575  Nozaki H, Yanagida M, Koide K, Shiotani K, Kinoshita M, Kobayashi Y, Watarai S, Nakamura K, Suzuki A, Ariga T, Kushi Y.  Production and characterization of monoclonal antibodies specific to lactotriaosylceramide  Glycobiology  2010  20(12):1631-42  PubMed ID: 20693232   DOI: 10.1093/glycob/cwq117
6125  Shimahara A, Yamakawa N, Nishikata I, Morishita K.  Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.  J Biol Chem  2010  285(22):16967-77  PubMed ID: 20363750   DOI: 10.1074/jbc.M110.102046
9155  Soninkhishig Tsolmon, Junkyu Han, Hiroko Isoda  Inhibition of Cell Growth by Stellera Chamaejasme Extract Is Associated With Induction of Autophagy and Differentiation in Chronic Leukemia K562 Cells  J Biosci Bioeng  2010  110 (2), 262-8  PubMed ID: 20547324   DOI: 10.1016/j.jbiosc.2010.02.006
18822  Kondo N, Nishimura S.  MALDI-TOF mass-spectrometry-based versatile method for the characterization of protein kinases  Chemistry  2009  5(6):1413-21  PubMed ID: 19115309   DOI: 10.1002/chem.200801650
5396  Hosomi O, Misawa Y, Takeya A, Matahira Y, Sugahara K, Kubohara Y, Yamakura F, Kudo S.  Novel oligosaccharide has suppressive activity against human leukemia cell proliferation.  Glycoconj J  2009  26(2):189-98  PubMed ID: 18726690   DOI: 10.1007/s10719-008-9175-z
8795  Engelhardt P, Merilainen J, Zhao F, Uchiyama S, Fukui K, Lehto VP.  Whole-mount immunoelectron tomography of chromosomes and cells.  Methods Mol. Biol.  2007  369:387-405  PubMed ID: 17656761   DOI: 10.1007/978-1-59745-294-6_19
3407  Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi  Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.  Am J Physiol Endocrinol Metab  2005  288:E1101-9  PubMed ID: 15671080   DOI: 10.1152/ajpendo.00502.2004
9051  Tominaga K, Kagata T, Johmura Y, Hishida T, Nishizuka M, Imagawa M.  SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc.  FEBS J.  2005  272:1590-9  PubMed ID: 15794747   DOI: 10.1111/j.1742-4658.2005.04580.x
3170  Harada H, Suzu S, Ito T, Okada S.  Selective expansion and engraftment of human CD16+ NK cells in NOD/SCID mice.  Eur J Immunol  2005  35(12):3599-609  PubMed ID: 16304638   DOI: 10.1002/eji.200535125
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2983  Kawano T, Horiguchi-Yamada J, Iwase S, Akiyama M, Furukawa Y, Kan Y, Yamada H.  Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect.  Anticancer Res  2004  24(5A):2705-12  PubMed ID: 15517875  
2984  Kawano T, Horiguchi-Yamada J, Saito S, Iwase S, Furukawa Y, Kano Y, Yamada H.  Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.  Leuk Res  2004  28(6):623-9  PubMed ID: 15120940   DOI: 10.1016/j.leukres.2003.10.022
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