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Cell No. : Cell Name
RCB0027 : K562  update : 2022/10/04
CommentHuman cell line derived from chronic myelogenous leukemia. Sensitive to NK cells. Differentiate to erythroid cells.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Kanazawa, Satoshi
Originator Lozzio, C.B. & Lozzio, B.B.
Year of deposit 1986
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 53 years
Tissue pleural effusion
Disease name chronic myelogenous leukemia
Classification cancer
Lifespan infinite
Morphology lymphoblast-like
Cellosaurus(Expasy) CVCL_0004
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives HamF12 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HIV) (-)
Virus (HTLV-1) (-)
Isozyme LD, NP
Chromosome mode 59-68(50) : /63(5),64(7),65(6),66(8),67(16),68(5)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 73


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Reference
5042  Haruta Y, Seon BK.  Distinct human leukemia-associated cell surface glycoprotein GP160 defined by monoclonal antibody SN6.  Proc Natl Acad Sci U S A  1986  83(20):7898-902  PubMed ID: 3464004   DOI: 10.1073/pnas.83.20.7898
4603  Lozzio BB, Lozzio CB.  Properties and usefulness of the original K-562 human myelogenous leukemia cell line.  Leuk Res  1979  3(6):363-70  PubMed ID: 95026   DOI: 10.1016/0145-2126(79)90033-x
969  Rutherford TR, Clegg JB, Weatherall DJ.  K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin.  Nature  1979  280(5718):164-5  PubMed ID: 95354   DOI: 10.1038/280164a0
970  Andersson LC, Jokinen M, Gahmberg CG.  Induction of erythroid differentiation in the human leukaemia cell line K562.  Nature  1979  278(5702):364-5  PubMed ID: 570644   DOI: 10.1038/278364a0
4602  Lozzio CB, Lozzio BB.  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome.  Blood  1975  45(3):321-34  PubMed ID: 163658  

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User's Publication
13403  Takeuchi R, Suzuki M, Yasukawa T.  Electrorotation Rates of K562 Cells Accompanied with the Erythroid Differentiation Induced by Sodium Butyrate.  Anal Sci  2021    PubMed ID: 33390466   DOI: 10.2116/analsci.20C017
20082  Yoshimura A, Asahina Y, Chang LY, Angata T, Tanaka H, Kitajima K, Sato C.  Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells.  J Biol Chem  2021  100477  PubMed ID: 33640457   DOI: 10.1016/j.jbc.2021.100477
16204  Kondo S, Ferdousi F, Yamauchi K, Suidasari S, Yokozawa M, Harrabi MM, Tominaga KI, Isoda H.  Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells  J Cell Mol Med  2021  25(15):7229-7243  PubMed ID: 34180123   DOI: 10.1111/jcmm.16752
13052  Kawai S, Suzuki M, Arimoto S, Korenaga T, Yasukawa T.  Determination of membrane capacitance and cytoplasm conductivity by simultaneous electrorotation.  Analyst  2020    PubMed ID: 32462157   DOI: 10.1039/d0an00100g
13914  Takano M, Higashi M, Baba S, Kawami M, Yumoto R.  Transport of ribavirin in human myelogenous leukemia cell line K562  Pharmazie  2020  75(7):329-334  PubMed ID: 32635975   DOI: 10.1691/ph.2020.0440
14798  Kondo T, Ando M, Nagai N, Tomisato W, Srirat T, Liu B, Mise-Omata S, Ikeda M, Chikuma S, Nishimasu H, Nureki O, Ohmura M, Hayakawa N, Hishiki T, Uchibori R, Ozawa K, Yoshimura A.  The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells  Cancer Res  2020  80(3):471-483  PubMed ID: 31767627   DOI: 10.1158/0008-5472.CAN-19-1196
11537  Miura S, Kobune M, Horiguchi H, Kikuchi S, Iyama S, Murase K, Goto A, Ikeda H, Takada K, Miyanishi K, Kato J.  EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells.  Blood Cells Mol. Dis.  2019    PubMed ID: 31082798   DOI: 10.1016/j.bcmd.2019.04.014
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478   DOI: 10.1038/s41598-019-44817-9
11677  Ryohichi Sugimura, Ryo Ohta, Chihiro Mori, Emi Sano, Tatsuki Sugiyama, Takashi Nagasawa, Akira Niwa,  Angiocrine factors from HUVECs amplify erythroid cells  bioRxiv  2019      DOI: 10.1101/837823
11093  Abdelmoez MN, Iida K, Oguchi Y, Nishikii H, Yokokawa R, Kotera H, Uemura S, Santiago JG, Shintaku H.  SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.  Genome Biol.  2018  19(1):66  PubMed ID: 29871653   DOI: 10.1186/s13059-018-1446-9
4267  Kikuchi G, Kurita R, Ogasawara K, Isa K, Tsuneyama H, Nakamura Y, Yabe R, Shiba M, Tadokoro K, Nagai T, Satake M.  Application of immortalized human erythroid progenitor cell line in serologic tests to detect red blood cell alloantibodies.  Transfusion  2018    PubMed ID: 30180269   DOI: 10.1111/trf.14840
4270  Ichii M, Oritani K, Murase M, Komatsu K, Yamazaki M, Kyoden R, Kito N, Nozaki Y, Saito M, Iwamura H, Kanakura Y.  Molecular targeting of inosine-5'-monophosphate dehydrogenase by FF-10501 promotes erythropoiesis via ROS/MAPK pathway.  Leuk. Lymphoma  2018    PubMed ID: 28730859   DOI: 10.1080/10428194.2017.1339878
4378  Miyauchi M, Koya J, Arai S, Yamazaki S, Honda A, Kataoka K, Yoshimi A, Taoka K, Kumano K, Kurokawa M.  ADAM8 Is an Antigen of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia Cells Identified by Patient-Derived Induced Pluripotent Stem Cells.  Stem Cell Reports  2018  10(3):1115-1130  PubMed ID: 29429960   DOI: 10.1016/j.stemcr.2018.01.015
15049  Ureshino H, Shindo T, Kojima H, Kusunoki Y, Miyazaki Y, Tanaka H, Saji H, Kawaguchi A, Kimura S.  Allelic Polymorphisms of KIR s and HLA s Predict Favorable Responses to Tyrosine Kinase Inhibitors in CML  Cancer Immunol Res  2018  6(6):745-754  PubMed ID: 29695383   DOI: 10.1158/2326-6066.CIR-17-0462
14689  Takagishi T, Takehara M, Seike S, Miyamoto K, Kobayashi K, Nagahama M.  Clostridium perfringens α-toxin impairs erythropoiesis by inhibition of erythroid differentiation  Sci Rep  2017  7(1):5217  PubMed ID: 28701754   DOI: 10.1038/s41598-017-05567-8
14775  Mahmoud N. Abdelmoez, Kei Iida, Yusuke Oguchi, Hidekazu Nishikii, Ryuji Yokokawa, Hidetoshi Kotera, Sotaro Uemura, Juan G. Santiago, Hirofumi Shintaku  Correlation of gene expressions between nucleus and cytoplasm reflects single-cell physiology  bioRxiv  2017  October 20, 2017    DOI: 10.1101/206672
9546  Nakamura A, Monzen S, Takasugi Y, Wojcik A, Mariya Y.  Application of cell sorting for enhancing the performance of the cytokinesis-block micronucleus assay.  J. Radiat. Res.  2016  57:121-6  PubMed ID: 26826197   DOI: 10.1093/jrr/rrv103
5654  Sadahira Y, Sugihara T, Fujiwara H, Nishimura H, Suetsugu Y, Takeshita M, Okamura S, Goto M.  WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.  Virchows Arch  2015  466(3):343-50  PubMed ID: 25503078   DOI: 10.1007/s00428-014-1703-6
13879  Isoda H, Motojima H, Onaga S, Samet I, Villareal MO, Han J.  Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells  Chem Biol Interact  2014  220:269-77  PubMed ID: 25058688   DOI: 10.1016/j.cbi.2014.07.006
9087  Kenta Okamoto, Hitomi Kinoshita, Maria Del Carmen Parquet, Muhareva Raekiansyah, Daisuke Kimura, Katsuyuki Yui, Mohammed Alimul Islam, Futoshi Hasebe, Kouichi Morita  Dengue Virus Strain DEN2 16681 Utilizes a Specific Glycochain of syndecan-2 Proteoglycan as a Receptor  J Gen Virol  2012  93 (Pt 4), 761-770  PubMed ID: 22170634   DOI: 10.1099/vir.0.037853-0
9088  Haiyan Gong, Kyousuke Kobayashi, Tatsuki Sugi, Hitoshi Takemae, Hitomi Kurokawa, Taisuke Horimoto, Hiroomi Akashi, Kentaro Kato  A Novel PAN/apple Domain-Containing Protein From Toxoplasma Gondii: Characterization and Receptor Identification  PLoS One  2012  7 (1), e30169  PubMed ID: 22276154   DOI: 10.1371/journal.pone.0030169
10993  Soninkhishig Tsolmon, Eri Nakazaki, Junkyu Han, Hiroko Isoda  Apigetrin induces erythroid differentiation of human leukemia cells K562: proteomics approach  Mol Nutr Food Res  2011  55 Suppl 1:S93-S102  PubMed ID: 21480518   DOI: 10.1002/mnfr.201000650
12292  Yujiro Tanaka, Koji Kawahashi, Zen-Ichiro Katagiri, Yasuhiro Nakayama, Milind Mahajan, Dimitris Kioussis  Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression  PLoS One  2011  6(11):e28171  PubMed ID: 22140534   DOI: 10.1371/journal.pone.0028171
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9155  Soninkhishig Tsolmon, Junkyu Han, Hiroko Isoda  Inhibition of Cell Growth by Stellera Chamaejasme Extract Is Associated With Induction of Autophagy and Differentiation in Chronic Leukemia K562 Cells  J Biosci Bioeng  2010  110 (2), 262-8  PubMed ID: 20547324   DOI: 10.1016/j.jbiosc.2010.02.006
5396  Hosomi O, Misawa Y, Takeya A, Matahira Y, Sugahara K, Kubohara Y, Yamakura F, Kudo S.  Novel oligosaccharide has suppressive activity against human leukemia cell proliferation.  Glycoconj J  2009  26(2):189-98  PubMed ID: 18726690   DOI: 10.1007/s10719-008-9175-z
8795  Engelhardt P, Merilainen J, Zhao F, Uchiyama S, Fukui K, Lehto VP.  Whole-mount immunoelectron tomography of chromosomes and cells.  Methods Mol. Biol.  2007  369:387-405  PubMed ID: 17656761   DOI: 10.1007/978-1-59745-294-6_19
3407  Ito, Mikiko, Sakai, Yuko, Furumoto, Mari, Segawa, Hiroko, Haito, Sakiko, Yamanaka, Setsuko, Nakamura, Rie, Kuwahata, Masashi, Miyamoto, Ken-ichi  Vitamin D and phosphate regulate fibroblast growth factor-23 in K-562 cells.  Am J Physiol Endocrinol Metab  2005  288:E1101-9  PubMed ID: 15671080   DOI: 10.1152/ajpendo.00502.2004
9051  Tominaga K, Kagata T, Johmura Y, Hishida T, Nishizuka M, Imagawa M.  SLC39A14, a LZT protein, is induced in adipogenesis and transports zinc.  FEBS J.  2005  272:1590-9  PubMed ID: 15794747   DOI: 10.1111/j.1742-4658.2005.04580.x
3170  Harada H, Suzu S, Ito T, Okada S.  Selective expansion and engraftment of human CD16+ NK cells in NOD/SCID mice.  Eur J Immunol  2005  35(12):3599-609  PubMed ID: 16304638   DOI: 10.1002/eji.200535125
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
2706  Harada H, Watanabe S, Saijo K, Ishiwata I, Ohno T  A Wilms tumor cell line, HFWT, can greatly stimulate proliferation of CD56+ human natural killer cells and their novel precursors in blood mononuclear cells.  Exp Hematol  2004  32:614-21  PubMed ID: 15246157   DOI: 10.1016/j.exphem.2004.03.011
2848  Feng, Xingmin, Chuhjo, Tatsuya, Sugimori, Chiharu, Kotani, Takeharu, Lu, Xuzhang, Takami, Akiyoshi, Takamatsu, Hiroyuki, Yamazaki, Hirohito, Nakao, Shinji  Diazepam-binding inhibitor-related protein 1: a candidate autoantigen in acquired aplastic anemia patients harboring a minor population of paroxysmal nocturnal hemoglobinuria-type cells.  Blood  2004  104:2425-31  PubMed ID: 15217832   DOI: 10.1182/blood-2004-05-1839
2880  Okada M, Adachi S, Imai T, Watanabe K, Toyokuni SY, Ueno M, Zervos AS, Kroemer G, Nakahata T.  A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.  Blood  2004  103(6):2299-307  PubMed ID: 14645012   DOI: 10.1182/blood-2003-05-1605
2983  Kawano T, Horiguchi-Yamada J, Iwase S, Akiyama M, Furukawa Y, Kan Y, Yamada H.  Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect.  Anticancer Res  2004  24(5A):2705-12  PubMed ID: 15517875  
2984  Kawano T, Horiguchi-Yamada J, Saito S, Iwase S, Furukawa Y, Kano Y, Yamada H.  Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.  Leuk Res  2004  28(6):623-9  PubMed ID: 15120940   DOI: 10.1016/j.leukres.2003.10.022
2985  Kawano T, Horiguchi-Yamada J, Iwase S, Furukawa Y, Kano Y, Yamada H.  Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.  Mol Cell Biochem  2004  58(1-2):25-33  PubMed ID: 15030167   DOI: 10.1023/b:mcbi.0000012830.96393.b9
3118  Uchiyama S, Kobayashi S, Takata H, Ishihara T, Sone T, Matsunaga S, Fukui K.  Protein composition of human metaphase chromosomes analyzed by two-dimensional electrophoreses.  Cytogenet Genome Res  2004  107(1-2):49-54  PubMed ID: 15305056   DOI: 10.1159/000079571
9534  Shunji Aoki, Dexin Kong, Kouhei Matsui, Rachmaniar Rachmat, Motomasa Kobayashi  Sesquiterpene Aminoquinones, From a Marine Sponge, Induce Erythroid Differentiation in Human Chronic Myelogenous Leukemia, K562 Cells  Chem Pharm Bull (Tokyo)   2004  52(8):935-7  PubMed ID: 15304984   DOI: 10.1248/cpb.52.935
9559  Shunji Aoki, Dexin Kong, Kouhei Matsui, Motomasa Kobayashi  Erythroid Differentiation in K562 Chronic Myelogenous Cells Induced by Crambescidin 800, a Pentacyclic Guanidine Alkaloid  Anticancer Res  2004  24(4):2325-30.  PubMed ID: 15330179  
3979  Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.  Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.  J Nat Prod  2003  66(8):1124-7  PubMed ID: 12932141   DOI: 10.1021/np020546u
9586  Kazuko Yamazaki, Emiko Yamada, Yoshio Kanaji, Tetsuo Yanagisawa, Yoshiyuki Kato, Kanji Sato, Kazue Takano, Yuji Sakasegawa, Kiyotoshi Kaneko  Stimulation of Cellular Prion Protein Expression by TSH in Human Thyrocytes  Biochem Biophys Res Commun  2003  305(4):1034-9  PubMed ID: 12767934   DOI: 10.1016/s0006-291x(03)00801-5
13868  Kobayashi T, Yamanaka R, Homma J, Tsuchiya N, Yajima N, Yoshida S, Tanaka R.  Tumor mRNA-loaded dendritic cells elicit tumor-specific CD8(+) cytotoxic T cells in patients with malignant glioma  Cancer Immunol Immunother  2003  52(10):632-7  PubMed ID: 12827308   DOI: 10.1007/s00262-003-0408-5
14421  Takahashi T, Haraguchi K, Chiba S, Yasukawa M, Shibata Y, Hirai H.  Valpha24+ natural killer T-cell responses against T-acute lymphoblastic leukaemia cells: implications for immunotherapy  Br J Haematol  2003  122(2):231-9  PubMed ID: 12846891   DOI: 10.1046/j.1365-2141.2003.04429.x
14422  Ueda Y, Hagihara M, Gansuvd B, Yu Y, Masui A, Okamoto A, Higuchi A, Tazume K, Kato S, Hotta T.  The effects of alphaGalCer-induced TCRValpha24 Vbeta11(+) natural killer T cells on NK cell cytotoxicity in umbilical cord blood  Cancer Immunol Immunother  2003  52(10):625-31  PubMed ID: 12802518   DOI: 10.1007/s00262-003-0398-3
2549  Nagai, Fusako, Hiyoshi, Yasuko, Sugimachi, Kumiko, Tamura, Hiro-Omi  Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines.  Biol Pharm Bull  2002  25:383-5  PubMed ID: 11913539   DOI: 10.1248/bpb.25.383
4885  Sonoyama J, Matsumura I, Ezoe S, Satoh Y, Zhang X, Kataoka Y, Takai E, Mizuki M, Machii T, Wakao H, Kanakura Y.  Functional cooperation among Ras, STAT5, and phosphatidylinositol 3-kinase is required for full oncogenic activities of BCR/ABL in K562 cells.  J Biol Chem  2002  277(10):8076-82  PubMed ID: 11779872   DOI: 10.1074/jbc.M111501200
2979  Horiguchi-Yamada J, Fukumi S, Saito S, Nakayama R, Iwase S, Yamada H.  DNA topoisomerase II inhibitor, etoposide, induces p21WAF1/CIP1 through down-regulation of c-Myc in K562 cells.  Anticancer Res  2002  22(6C):3827-32  PubMed ID: 12553001  
13865  Jiang B, Hattori N, Liu B, Kitagawa K, Inagaki C.  Expression of swelling- and/or pH-regulated chloride channels (ClC-2, 3, 4 and 5) in human leukemic and normal immune cells  Life Sci  2002  70(12):1383-94  PubMed ID: 11883714   DOI: 10.1016/s0024-3205(01)01517-x
15668  Akiyama M, Yamada O, Kanda N, Akita S, Kawano T, Ohno T, Mizoguchi H, Eto Y, Anderson KC, Yamada H.  Telomerase overexpression in K562 leukemia cells protects against apoptosis by serum deprivation and double-stranded DNA break inducing agents, but not against DNA synthesis inhibitors  Cancer Lett  2002  178(2):187-97  PubMed ID: 11867204   DOI: 10.1016/s0304-3835(01)00838-2
2550  Tamura, H O, Taniguchi K, Hayashi E, Hiyoshi Y, Nagai F  Expression profiling of sulfotransferases in human cell lines derived from extra-hepatic tissues.  Biol Pharm Bull  2001  24:1258-62  PubMed ID: 11725959   DOI: 10.1248/bpb.24.1258
13866  Hattori N, Saito T, Yagyu T, Jiang BH, Kitagawa K, Inagaki C.  GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils  J Clin Endocrinol Metab  2001  86(9):4284-91  PubMed ID: 11549663   DOI: 10.1210/jcem.86.9.7866
13876  Aoki S, Higuchi K, Isozumi N, Matsui K, Miyamoto Y, Itoh N, Tanaka K, Kobayashi M.  Differentiation in chronic myelogenous leukemia cell K562 by spongean sesterterpene  Biochem Biophys Res Commun  2001  282(2):426-31  PubMed ID: 11401476   DOI: 10.1006/bbrc.2001.4588
14425  Hagihara M, Tsuchiya T, Ueda Y, Masui A, Gansuvd B, Munkhbat B, Inoue H, Hyodo O, Ando K, Kato S, Hotta T.  Successful in vitro generation of Epstein-Barr virus-specific cytotoxic T lymphocytes from severe chronic active EBV patients  Med Microbiol Immunol  2001  189(3):137-45  PubMed ID: 11388611   DOI: 10.1007/s430-001-8020-z
2986  Fukumi S, Horiguchi-Yamada J, Iwase S, Ohno T, Yamada H.  Concentration-dependent variable effects of etoposide on the cell cycle of CML cells.  Anticancer Res  2000  20(5A):3105-10  PubMed ID: 11062729  
2987  Akiyama M, Yamada O, Akita S, Urashima M, Horiguchi-Yamada J, Ohno T, Mizoguchi H, Eto Y, Yamada H.  Ectopic expression of c-myc fails to overcome downregulation of telomerase activity induced by herbimycin A, but ectopic hTERT expression overcomes it.  Leukemia  2000  14(7):1260-5  PubMed ID: 10914551   DOI: 10.1038/sj.leu.2401828
2988  Fukumi S, Horiguchi-Yamada J, Nakada S, Nagai M, Ohno T, Yamada H.  Differential responses of Bcl-2 family genes to etoposide in chronic myeloid leukemia K562 cells.  Mol Cell Biochem  2000  206(1-2):43-50  PubMed ID: 10839193   DOI: 10.1023/a:1007056727876
15583  Naito K, Takeshita A, Shigeno K, Nakamura S, Fujisawa S, Shinjo K, Yoshida H, Ohnishi K, Mori M, Terakawa S, Ohno R.  Calicheamicin-conjugated humanized anti-CD33 monoclonal antibody (gemtuzumab zogamicin, CMA-676) shows cytocidal effect on CD33-positive leukemia cell lines, but is inactive on P-glycoprotein-expressing sublines  Leukemia  2000  14(8):1436-43  PubMed ID: 10942240   DOI: 10.1038/sj.leu.2401851
2381  Suzuki K, Tsujitani S, Konishi I, Yamaguchi Y, Hirooka Y, Kaibara N.  Expression of MAGE genes and survival in patients with hepatocellular carcinoma.  Int J Oncol  1999  15(6):1227-32  PubMed ID: 10568832   DOI: 10.3892/ijo.15.6.1227
15584  Sekine K, Fujii H, Abe F.  Induction of apoptosis by bestatin (ubenimex) in human leukemic cell lines  Leukemia  1999  13(5):729-34  PubMed ID: 10374877   DOI: 10.1038/sj.leu.2401388
2991  Yamada H, Horiguchi-Yamada J, Nagai M, Takahara S, Sekikawa T, Kawano T, Itoh K, Fukumi S, Iwase S.  Biological effects of a relatively low concentration of 1-beta-D-arabinofuranosylcytosine in K562 cells: alterations of the cell cycle, erythroid-differentiation, and apoptosis.  Mol Cell Biochem  1998  187(1-2):211-20  PubMed ID: 9788759   DOI: 10.1023/a:1006874931249
2320  Kim C, Matsumura M, Saijo K, Ohno T.  In vitro induction of HLA-A2402-restricted and carcinoembryonic-antigen-specific cytotoxic T lymphocytes on fixed autologous peripheral blood cells.  Cancer Immunol Immunother.  1998  47(2):90-6  PubMed ID: 9769117   DOI: 10.1007/s002620050508
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15667  Chino M, Nishikawa K, Yamada A, Ohsono M, Sawa T, Hanaoka F, Ishizuka M, Takeuchi T.  Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth  J Antibiot (Tokyo)  1998  ;51(5):480-6  PubMed ID: 9666176   DOI: 10.7164/antibiotics.51.480
13863  Isoda H, Nakahara T.  Mannosylerythritol lipid induces granulocytic differentiation and inhibits the tyrosine phosphorylation of human myelogenous leukemia cell line K562  Cytotechnology  1997  25(1-3):191-5  PubMed ID: 22358891   DOI: 10.1023/A:1007982909932
2054  Enomoto K, Furuya K, Moore, R C, Yamagishi S, Oka T, Maeno T  Expression cloning and signal transduction pathway of P2U receptor in mammary tumor cells  Biological Signals  1996  5:9-21  PubMed ID: 8739319   DOI: 10.1159/000109169
2989  Yamada H, Iwase S, Nagai M, Nemoto T, Sekikawa T, Takahara S, Nakada S, Furukawa Y, Horiguchi-Yamada J.  Herbimycin A down-regulates messages of cyclin D1 and c-myc during erythroid differentiation of K562 cells.  Int J Hematol  1996  65(1):31-40  PubMed ID: 8990623   DOI: 10.1016/s0925-5710(96)00526-9
13880  Okada M, Sagawa T, Tominaga A, Kodama T, Hitsumoto Y.  Two mechanisms for platelet-mediated killing of tumour cells: one cyclo-oxygenase dependent and the other nitric oxide dependent  Immunology  1996  89(1):158-64  PubMed ID: 8911154   DOI: 10.1046/j.1365-2567.1996.d01-716.x
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