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細胞番号 : 細胞名
RCB0009 : PC-12  update : 2024/03/08
細胞特性(Comment:英)Pheochromocytoma, differentiate by NGF stimulation. Application consideration
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Noda, Makoto
樹立者 L. Green & A. Tischler
寄託日 1986
動物種 _rat < Mammals
属名 Rattus
種名 norvegicus
採取組織 pheochromocytoma
細胞分類 cancer
入手歴 Mitubishi-Seimeiken-T.Amano
細胞寿命 infinite
細胞形態 other
Cellosaurus(Expasy) CVCL_0481
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS + 10% HS (GIBCO)
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 4-8 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
文献情報 Reference(英) 4件
Reference(日) 2件
利用者成果(英) 336件
利用者成果(日) 1件

1726  Satoh M, Takeuchi M  Establishment of HPRT-deficient cell lines from mouse neuroblastoma Neuro-2a and rat pheochromocytoma PC12.  Res Commun Inst Ferment  1993  16:6-17  PubMed ID: 7763725  
1078  Levi A, Eldridge, J D, Paterson, B M  Molecular cloning of a gene sequence regulated by nerve growth factor.  Science  1985  229:393-5  PubMed ID: 3839317   DOI: 10.1126/science.3839317
1079  Biocca S, Cattaneo A, Calissano P  A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).  EMBO J  1983  2:643-8  PubMed ID: 6641712   DOI: 10.1002/j.1460-2075.1983.tb01478.x
1318  Greene, L A, Tischler, A S  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.  Proc Natl Acad Sci U S A  1976  73:2424-8  PubMed ID: 1065897   DOI: 10.1073/pnas.73.7.2424

1716  畠中寛  ラット : PC12  生体の科学  1992  43:420   
1237  畠中寛  バイオテクノロジ-素材としての培養細胞 増殖因子  蛋白質 核酸 酵素  1988  33:1227-1238   

19537  Kazuo Nakazawa, Minako Matsuo, Yo Kikuchi, Yoshihiro Nakajima, Rika Numano  Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock  Frontiers in Neuroscience  2024  18    DOI: 10.3389/fnins.2024.1186677
21545  Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K.  Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice.  PLoS One  2024  19(1):e0296750  PubMed ID: 38181010   DOI: 10.1371/journal.pone.0296750
21590  Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, Inoue A, Maruyama T, Kudo TA, Hirata Y, Shindo S, Uchida Y, Hwang GW, Matsuzawa A.  Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos.  Cell Death Discov  2024  10(1):74  PubMed ID: 38346947   DOI: 10.1038/s41420-024-01838-2
21719  Chuma S, Kiyosue K, Akiyama T, Kinoshita M, Shimazaki Y, Uchiyama S, Sotoma S, Okabe K, Harada Y.  Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature.  Nat Commun  2024  15(1):3473  PubMed ID: 38724563   DOI: 10.1038/s41467-024-47542-8
19538  Okami H, Kawaharada R, Yoshizaki H, Toriumi A, Tsutsumi S, Nakamura A.  Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model  Nutrients  2023  15(15):3434  PubMed ID: 37571372   DOI: 10.3390/nu15153434
19564  Sasayama Y, Mamiya T, Qi J, Shibata T, Uchida K, Nabeshima T, Ojika M.  Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-acceler  Bioorg Med Chem  2023  78:117144  PubMed ID: 36577328   DOI: 10.1016/j.bmc.2022.117144
19648  Florence Hui Ping Tan, Andrew Chung Jie Ting, Nazalan Najimudin, Nobumoto Watanabe, Shaharum Shamsuddin, Azalina Zainuddin, Hiroyuki Osada, Ghows Azzam  3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer’s Disease Drosophila  The Journals of Gerontology: Series A  2023  78:1944-1952    DOI: 10.1093/gerona/glad169
19657  Mochizuki R, Kobayashi A, Takayama H, Toida T, Ogra Y.  Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction  Anal Methods  2023  15(28):3426-3431  PubMed ID: 37427721   DOI: 10.1039/d3ay00860f
19920  Tan FHP, Najimudin N, Watanabe N, Shamsuddin S, Azzam G.  p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model  Behav Brain Res  2023  452:114568  PubMed ID: 37414223   DOI: 10.1016/j.bbr.2023.114568
20995  Kiya R, Tang T, Tanaka Y, Hosokawa Y, Yalikun Y.  Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser.  Sci Rep  2023  13(1):405  PubMed ID: 36624119   DOI: 10.1038/s41598-022-27229-0
21075  Shibato J, Takenoya F, Yamashita M, Gupta R, Min CW, Kim ST, Kimura A, Takasaki I, Hori M, Shioda S, Rakwal R.  OMICS Analyses Unraveling Related Gene and Protein-Driven Molecular Mechanisms Underlying PACAP 38-Induced Neurite Outgrowth in PC12 Cells.  Int J Mol Sci  2023  24(4)  PubMed ID: 36835581   DOI: 10.3390/ijms24044169
21139  Ikemoto MJ, Aihara Y, Ishii N, Shigemori H.  3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.  Biol Pharm Bull  2023  46(4):599-607  PubMed ID: 37005304   DOI: 10.1248/bpb.b22-00727
21190  Yoshinaga N, Tateishi A, Kobayashi Y, Kubo T, Miyakawa H, Satoh K, Numata K.  Effect of Oligomers Derived from Biodegradable Polyesters on Eco- and Neurotoxicity.  Biomacromolecules  2023    PubMed ID: 37085155   DOI: 10.1021/acs.biomac.3c00160
21359  Nakamura M, Araki H, Tsurushima H, Oyane A.  Fabrication of water-dispersible and cell-stimulating calcium phosphate nanoparticles immobilizing basic fibroblast growth factor.  Colloids Surf B Biointerfaces  2023  230:113502  PubMed ID: 37574618   DOI: 10.1016/j.colsurfb.2023.113502
21393  Okumura H, Itoh SG, Zen H, Nakamura K.  Dissociation process of polyalanine aggregates by free electron laser irradiation.  PLoS One  2023  18(9):e0291093  PubMed ID: 37683014   DOI: 10.1371/journal.pone.0291093
21549  Tomita K, Oohara Y, Igarashi K, Kitanaka J, Kitanaka N, Tanaka KI, Roudkenar MH, Roushandeh AM, Sugimura M, Sato T.  Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice.  Heliyon  2023  9(12):e22784  PubMed ID: 38090003   DOI: 10.1016/j.heliyon.2023.e22784
21558  Mochizuki R, Ogra Y.  Determination of intracellular dopamine by liquid chromatography-fluorescence detection with post-column derivatization using the König reaction.  J Chromatogr B Analyt Technol Biomed Life Sci  2023  1232:123956  PubMed ID: 38128164   DOI: 10.1016/j.jchromb.2023.123956
17505  Owada R, Mitsui S, Nakamura K.  Exogenous polyserine and polyleucine are toxic to recipient cells  Sci Rep  2022  12(1):1685  PubMed ID: 35102230   DOI: 10.1038/s41598-022-05720-y
17513  Jamal M, Tsukamoto I, Maki T, Takei S, Konishi R, Kinoshita H.  COA-Cl Evokes Protective Responses Against H2O2-and 6-OHDA-Induced Toxic Injury in PC12 Cells  Neurotox Res  2022  40(6):2061-2071  PubMed ID: 36435924   DOI: 10.1007/s12640-022-00587-3
17535  Daichi Nagashima, Chisa Matsubara, Noa Mizukami, Akane Nakagawa, Megumi Furukawa, Masahiro Toho, Ryoken Aoki, Yasuo Watanabe and Nobuo Izumo  Effect of Coriander on H2O2-induced Oxidative Stress in PC12 Cells  Journal of Clinical and Medical Research  2022      DOI: 10.37191/mapsci-2582-4333-4(3)-115
17684  Luo YR, Kudo TA, Tominami K, Izumi S, Tanaka T, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G, Wang H.  SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells  Int J Mol Sci  2022  23(24):15602  PubMed ID: 36555248   DOI: 10.3390/ijms232415602
17937  Morimoto E, Inagaki K, Komatsubara M, Terasaka T, Itoh Y, Fujisawa S, Sasaki E, Nishiyama Y, Hara T, Wada J.  Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells  J Endocr Soc  2022  6(10):bvac121  PubMed ID: 36042979   DOI: 10.1210/jendso/bvac121
20405  Uchida M, Ushio S, Niimura T, Takechi K, Kawazoe H, Hidaka N, Tanaka A, Araki H, Zamami Y, Ishizawa K, Kitamura Y, Sendou T, Kawasaki H, Namba H, Shibata K, Tanaka M, Takatori S.  Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation.  Biol Pharm Bull  2022    PubMed ID: 34803077   DOI: 10.1248/bpb.b21-00852
20499  Tomita K, Yamanishi-Taira S, Igarashi K, Oogai Y, Kuwahara Y, Roudkenar MH, Roushandeh AM, Miyawaki S, Kurimasa A, Sato T.  Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells.  Peptides  2022  170734  PubMed ID: 34974081   DOI: 10.1016/j.peptides.2021.170734
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
20919  Owada R, Kakuta Y, Yoshida K, Mitsui S, Nakamura K.  Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice.  Sci Rep  2022  12(1):18718  PubMed ID: 36333586   DOI: 10.1038/s41598-022-23571-5
20949  Chua P, Lim WK.  The strategic uses of collagen in adherent cell cultures.  Cell Biol Int  2022    PubMed ID: 36423248   DOI: 10.1002/cbin.11966
20958  Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M, Funato H.  Kinase signalling in excitatory neurons regulates sleep quantity and depth.  Nature  2022    PubMed ID: 36477539   DOI: 10.1038/s41586-022-05450-1
21026  Shinagawa T, Miyata S.  Three-Dimensional Cell Drawing Technique in Hydrogel Using Micro Injection System.  Micromachines (Basel)  2022  13(11)  PubMed ID: 36363885   DOI: 10.3390/mi13111866
21146  Koga T, Tai A.  Neurite Outgrowth-Promoting Compounds from Cockscomb Hydrolysate.  Nutrients  2022  14(7)  PubMed ID: 35406035   DOI: 10.3390/nu14071422
13538  Oguro A, Ishihara Y, Siswanto FM, Yamazaki T, Ishida A, Imaishi H, Imaoka S.  Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease  Biochim Biophys Acta Mol Cell Biol Lipids  2021  1866(2):158858  PubMed ID: 33279658   DOI: 10.1016/j.bbalip.2020.158858
20109  Chua P, Lim WK.  Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents.  Sci Rep  2021    PubMed ID: 33854099   DOI: 10.1038/s41598-021-87431-4
14195  Zhang T, Namoto M, Okano K, Akita E, Teranishi N, Tang T, Anggraini D, Hao Y, Tanaka Y, Inglis D, Yalikun Y, Li M, Hosokawa Y.  Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers  Sci Rep  2021  11(1):1652  PubMed ID: 33462348   DOI: 10.1038/s41598-021-81190-y
20171  Ando E, Higashi S, Mizokami A, Watanabe S, Hirata M, Takeuchi H.  Osteocalcin promotes proliferation, differentiation, and survival of PC12 cells.  Biochem Biophys Res Commun  2021  557:174-179  PubMed ID: 33865226   DOI: 10.1016/j.bbrc.2021.03.146
20333  Liang Y, Ueno M, Zha S, Okimura T, Jiang Z, Yamaguchi K, Hatakeyama T, Oda T.  Sulfated polysaccharide ascophyllan prevents amyloid fibril formation of human insulin and inhibits amyloid-induced hemolysis and cytotoxicity in PC12 cells.  Biosci Biotechnol Biochem  2021    PubMed ID: 34519773   DOI: 10.1093/bbb/zbab163
20463  Iizuka Y, Owada R, Kawasaki T, Hayashi F, Sonoyama M, Nakamura K.  Toxicity of internalized polyalanine to cells depends on aggregation.  Sci Rep  2021  11(1):23441  PubMed ID: 34873226   DOI: 10.1038/s41598-021-02889-6
16041  Tan FHP, Hadri NAB, Najimudin N, Watanabe N, Azzam G.  Ethyl caffeate ameliorated amyloid-beta42 protein-associated toxicity in PC12 cells and Drosophila melanogaster  Geriatr Gerontol Int   2021  21(12):1125-1130  PubMed ID: 34699118   DOI: 10.1111/ggi.14296
16234  Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, Azzam G.  Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease  J Ethnopharmacol  2021  8;279:114389  PubMed ID: 34217797   DOI: 10.1016/j.jep.2021.114389
16426  Li Xiao, Feng Liao, Yumei Fan, Nobuhiko Miwa  Ren Shen Yang Rong Tang and other traditional Chinese medicines exhibit antioxidant and anti-inflammatory capacities and suppress acetylcholinesterase activity in PC12 neuronal cells  Longhua Chinese Medicine  2021  4:13-13    DOI: 10.21037/lcm-21-12
20757  Shibato J, Takenoya F, Hirabayashi T, Kimura A, Yamashita M, Takasaki I, Rakwal R, Shioda S.  Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells.  Neural Plast  2021  2522454  PubMed ID: 34422037   DOI: 10.1155/2021/2522454
16796  Honda A, Hayasaka O, Mio K, Fujimura K, Kotani T, Komatsu M, Shiozaki K.  The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis  Biochimie  2021  185:105-116  PubMed ID: 33746065   DOI: 10.1016/j.biochi.2021.03.008
17754  Yamaguchi K, Mitsunaga T, Yamauchi K.  6-Paradol and its glucoside improve memory disorder in mice  Food Funct  2020  11(11):9892-9902  PubMed ID: 33094793   DOI: 10.1039/d0fo01975e
11760  Hsu YI, Yamaoka T.  Improved exposure of bioactive peptides to the outermost surface of the polylactic acid nanofiber scaffold.  J. Biomed. Mater. Res. Part B Appl. Biomater.  2020  108(4):1274-1280.  PubMed ID: 31429188   DOI: 10.1002/jbm.b.34475
11937  Usuki T, Yoshimoto Y, Sato M, Takenaka T, Takezawa R, Yoshida Y, Satake M, Suzuki N, Hashizume D, Dzyuba SV.  Bilobalide and PC12 cells: A structure activity relationship study.  Bioorg. Med. Chem.  2020    PubMed ID: 31848115   DOI: 10.1016/j.bmc.2019.115251
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870   DOI: 10.1016/j.heliyon.2020.e03301
13077  Xiao L, Liao F, Ide R, Horie T, Fan Y, Saiki C, Miwa N.  Enzyme-digested Colla Corii Asini (E'jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells.  Neural Regen Res  2020    PubMed ID: 32594048   DOI: 10.4103/1673-5374.285000
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13120  Tanaka N, Okuda M, Nishigaki T, Tsuchiya N, Kobayashi Y, Uemura T, Kumo S, Sugimoto H, Miyata S, Waku T.  Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins.  PLoS One  2020    PubMed ID: 32706773   DOI: 10.1371/journal.pone.0235979
13177  Nishimura A, Suwabe R, Ogihara Y, Yoshida S, Abe H, Osawa SI, Nakagawa A, Tominaga T, Nishizawa M.  Totally transparent hydrogel-based subdural electrode with patterned salt bridge.  Biomed Microdevices  2020    PubMed ID: 32827271   DOI: 10.1007/s10544-020-00517-0
13208  Owada R, Awata S, Suzue K, Kanetaka H, Kakuta Y, Nakamura K.  Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells.  Heliyon  2020    PubMed ID: 32954034   DOI: 10.1016/j.heliyon.2020.e04851
13366  Kobayashi Y, Oguro A, Yagi E, Mitani A, Kudoh SN, Imaoka S.  Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells.  J Toxicol Sci  2020    PubMed ID: 33268678   DOI: 10.2131/jts.45.783
13555  Koga T, Sakamoto T, Sakuradani E, Tai A.  Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds  Molecules  2020  25(20):4748  PubMed ID: 33081156   DOI: 10.3390/molecules25204748
13596  Rascher M, Wittstein K, Winter B, Rupcic Z, Wolf-Asseburg A, Stadler M, Köster RW.  Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction  Biomolecules  2020  10(10):1440  PubMed ID: 33066380   DOI: 10.3390/biom10101440
13642  Ikegami Y, Ijima H.  Development of heparin-conjugated nanofibers and a novel biological signal by immobilized growth factors for peripheral nerve regeneration  J Biosci Bioeng  2020  129(3):354-362  PubMed ID: 31601468   DOI: 10.1016/j.jbiosc.2019.09.004
13896  Madoka IMURA, Soichiro YAMADA, Koji YAMAMOTO, Yusuke MORITA, Eiji NAKAMACHI  Development of a three-dimensional cell culture system for the enhancement of nerve axonal extension by cyclic stretch stimulation  Journal of Biomechanical Science and Engineering  2020  15(4):20    DOI: 10.1299/jbse.20-00094
13942  Eiji NAKAMACHI, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA, Manabu OKITA  Development of a three-dimensional direct current electric field stimulation bioreactor to enhance the axonal outgrowth and control the axonal orientation  Journal of Biomechanical Science and Engineering  2020  15:19-00480    DOI: 10.1299/jbse.19-00480
14848  Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y.  Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study  Molecules  2020  25(18):420  PubMed ID: 32937854   DOI: 10.3390/molecules25184206
11262  Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H.  COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.  Brain Res.  2019    PubMed ID: 30366020   DOI: 10.1016/j.brainres.2018.10.026
11287  Nishizaki T.  Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death.  Mol. Neurobiol.  2019  56(7):4812-4819  PubMed ID: 30402707   DOI: 10.1007/s12035-018-1408-y
11420  Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.  Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.  Bioorg. Med. Chem.  2019    PubMed ID: 30733085   DOI: 10.1016/j.bmc.2019.01.038
11406  Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Okano Y, Masaki H.  3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress.  Exp. Dermatol.  2019    PubMed ID: 30698879   DOI: 10.1111/exd.13820
11488  Matsushima Y, Terada K, Kamei C, Sugimoto Y.  Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.  Eur. J. Pharmacol.  2019    PubMed ID: 30902656   DOI: 10.1016/j.ejphar.2019.03.032
4318  Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y.  Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells.  Biosci. Biotechnol. Biochem.  2019    PubMed ID: 30543144   DOI: 10.1080/09168451.2018.1553607
11658  Aruto Hori, Yuki Watabe, Masumi Yamada, Yuya Yajima, Rie Utoh, Minoru Seki  One-Step Formation of Microporous Hydrogel Sponges Encapsulating Living Cells by Utilizing Bicontinuous Dispersion of Aqueous Polymer Solutions  ACS Appl. Bio Mater.  2019    PubMed ID: 35030662   DOI: 10.1021/acsabm.9b00194
11812  Matsuzaki Y, Maruta R, Takaki K, Kotani E, Kato Y, Yoshimura R, Endo Y, Whitty C, Pernstich C, Gandhi R, Jones M, Mori H.  Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells.  Biomolecules  2019    PubMed ID: 31546991   DOI: 10.3390/biom9100510
9494  Keisuke Migita, Taichi Matsumoto, Kazuki Terada, Kazuhiko Ono, Shuji Hara  Effects of Geldanamycin on Neurite Outgrowth-Related Proteins and Kinases in Nerve Growth Factor-Differentiated Pheochromocytoma 12 Cells  J Pharmacol Sci  2019  140(3):255-262  PubMed ID: 31402210   DOI: 10.1016/j.jphs.2019.07.011
10509  Eiji NAKAMACHI, Ryota SAKIYAMA, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA  Enhancement of nerve axonal extension by an AC magnetic field stimulation bio-reactor using three-dimensional culture   Journal of Biomechanical Science and Engineering  2019  14(2)    DOI: 10.1299/jbse.19-00041
12153  Takanobu Haccho, Atsuru Kanno, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi  Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System  Plasma Medicine  2019      DOI: 10.1615/PlasmaMed.2020033059
12300  Florian Larramendy, Shotaro Yoshida, Daniela Maier, Zoltan Fekete, Shoji Takeuchi, Oliver Paul  3D arrays of microcages by two-photon lithography for spatial organization of living cells  Lab Chip   2019  19(5):875-884  PubMed ID: 30723853   DOI: 10.1039/c8lc01240g
12328  Ikeda T, Ichikawa K, Shigeto H, Ishida T, Hirota R, Funabashi H, Kuroda A.  Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish  Biosci Biotechnol Biochem  2019  83(12):2272-2275  PubMed ID: 31482750   DOI: 10.1080/09168451.2019.1659716
12361  Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.  Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy  J Neurochem  2019  148(3):373-385  PubMed ID: 30295925   DOI: 10.1111/jnc.14607
12550  Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M.  Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs  Medchemcomm  2019  0(7):1121-1125  PubMed ID: 31391884   DOI: 10.1039/c9md00011a
12551  Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.  Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice  J Cell Mol Med  2019  23(9):6283-6294  PubMed ID: 31257716   DOI: 10.1111/jcmm.14514
12552  Masukawa D, Yamada K, Goshima Y.  Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibits neurite outgrowth in PC12 cells  J Pharmacol Sci  2019  141(1):41-48  PubMed ID: 31606330   DOI: 10.1016/j.jphs.2019.09.002
10415  Mizukami-Murata S, Fujita K, Nakano T.  Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells.  Environ Sci Pollut Res Int  2018  25(17):16434-16445  PubMed ID: 28695493   DOI: 10.1007/s11356-017-9604-2
10540  Terada K, Matsushima Y, Matsunaga K, Takata J, Karube Y, Ishige A, Chiba K.  The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.  Bosn J Basic Med Sci  2018  18(3):224-233  PubMed ID: 28961087   DOI: 10.17305/bjbms.2017.2248
10615  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.  Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.  Eur. J. Pharmacol.  2018  819:35-42  PubMed ID: 29154935   DOI: 10.1016/j.ejphar.2017.11.024
10699  Murata T, Yamaguchi M, Kohno S, Takahashi C, Kakimoto M, Sugimura Y, Kamihara M, Hikita K, Kaneda N.  Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells.  FEBS Open Bio  2018  8:349-360  PubMed ID: 29511612   DOI: 10.1002/2211-5463.12374
10765  Sakagami H, Tsuji M, Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T, Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui T, Oizumi H, Oizumi T.  Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder.  In Vivo  2018  32:231-239  PubMed ID: 29475904   DOI: 10.21873/invivo.11229
11111  Sakagami H, Hara Y, Shi H, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells.  In Vivo  2018  32(4):765-770  PubMed ID: 29936457   DOI: 10.21873/invivo.11306
11143  Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K.  Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells.  Neurosci. Lett.  2018  685:42-4  PubMed ID: 30044955   DOI: 10.1016/j.neulet.2018.07.031
11215  Oguro A, Inoue T, Kudoh SN, Imaoka S.  14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.  Pharmacol Res Perspect  2018    PubMed ID: 30237892   DOI: 10.1002/prp2.428
11214  Koh I, Furusawa K, Haga H.  Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells.  Sci Rep  2018    PubMed ID: 30224813   DOI: 10.1038/s41598-018-32156-0
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454   DOI: 10.21873/invivo.11303
11255  Sano A, Shi H, Suzuki R, Shirataki Y, Sakagami H.  Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells.  In Vivo  2018    PubMed ID: 30348694   DOI: 10.21873/invivo.11392
11277  Nishizaki T.  Profilin facilitates PKCε activation by accelerating ATP supply.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30392913   DOI: 10.1016/j.bbrc.2018.10.114
11344  Terada K, Migita K, Matsushima Y, Sugimoto Y, Kamei C, Matsumoto T, Mori M, Matsunaga K, Takata J, Karube Y.  Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.  PLoS ONE  2018    PubMed ID: 30557385   DOI: 10.1371/journal.pone.0209250
4436    Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation  The Japan Society of Mechanical Engineers  2018  13,18-00024-18-00024    DOI: 10.1299/jbse.18-00024
4315  Sun Z, Liu Y, Kong X, Wang R, Xu Y, Shang C, Huo J, Huang M, Zhao F, Bian K, Zhang S, Tu Y, Chen X.  Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2.  Cell. Physiol. Biochem.  2018    PubMed ID: 29794460   DOI: 10.1159/000490017
4316  Sakagami H, Shi H, Bandow K, Tomomura M, Tomomura A, Horiuchi M, Fujisawa T, Oizumi T.  Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method.  Molecules  2018    PubMed ID: 30042342   DOI: 10.3390/molecules23081840
4317  Nishizaki T.  IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway.  Heliyon  2018    PubMed ID: 30533546   DOI: 10.1016/j.heliyon.2018.e00971
4381  Ohta M, Chosa N, Kyakumoto S, Yokota S, Okubo N, Nemoto A, Kamo M, Joh S, Satoh K, Ishisaki A.  IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals.  Int. J. Mol. Med.  2018  42(3):1484-1494  PubMed ID: 29901090   DOI: 10.3892/ijmm.2018.3714
4495  Masami Ishido  An Overview of Development of Quantitative Neurotoxicity Testing In vitro  Journal of Applied Life Sciences International  2018  19(2):1-9    DOI: 10.9734/JALSI/2018/45377
12549  Hsing‐An Lin, Bo Zhu, Yu‐Wei Wu, Jun Sekine, Aiko Nakao, Shyh‐Chyang Luo, Yoshiro Yamashita, Hsiao‐Hua Yu  Dynamic Poly(3,4‐ethylenedioxythiophene)s Integrate Low Impedance with Redox‐Switchable Biofunction  Advanced Functional Materials  2018  28    DOI: 10.1002/adfm.201703890
14539  Takanobu Haccho, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi  Development of Chemotherapy System Using Plasma Activated Medium to Enhance PC12 Axonal Extension  Biomedical and Biotechnology Engineering  2018  3    DOI: 10.1115/imece2018-86630
14543  Mizuki Fujiwara, Kyoichi Ono, Takashi K. Saito  Photo-Oxidative Cell Membrane Perforation and Applied Cellular Level Neural Interface and Electrophysiological Recording in Animal Cells  2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS)  2018      DOI: 10.1109/mhs.2018.8886985
9769  Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H.  GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells.  J. Cell. Biochem.  2017  118:699-708  PubMed ID: 27463736   DOI: 10.1002/jcb.25662
9780  Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI.  Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.  J. Antibiot.  2017  70:429-434  PubMed ID: 27507633   DOI: 10.1038/ja.2016.99
10129  Hozumi Y, Fujiwara H, Kaneko K, Fujii S, Topham MK, Watanabe M, Goto K.  Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells.  Cell Tissue Res.  2017  368:441-458  PubMed ID: 28191598   DOI: 10.1007/s00441-017-2579-y
10182  Mir TA, Shinohara H.  Two-Dimensional Surface Plasmon Resonance Imaging System for Cellular Analysis.  Methods Mol. Biol.  2017  1571:31-46  PubMed ID: 28281248   DOI: 10.1007/978-1-4939-6848-0_3
10391  Shinsuke K, Junya K, Tomonobu U, Yoshiko K, Izumo N, Takahiko S.  Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation.  J. Radiat. Res.  2017  58:809-815  PubMed ID: 29106600   DOI: 10.1093/jrr/rrx032
10485  Takahashi N, Onozuka W, Watanabe S, Wakasugi K.  Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth.  FEBS Open Bio  2017  7:1338-1349  PubMed ID: 28904863   DOI: 10.1002/2211-5463.12271
10511  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190   DOI: 10.1109/EMBC.2017.8037146
10513  Muroi T, Matsushima Y, Kanamori R, Inoue H, Fujii W, Yogo K.  GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice.  Reproduction  2017  154:755-764  PubMed ID: 28912303   DOI: 10.1530/REP-17-0333
10591  Tachizawa S, Takahashi H, Kim YJ, Odawara A, Pauty J, Ikeuchi Y, Suzuki I, Kikuchi A, Matsunaga YT.  Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding.  ACS Appl Mater Interfaces  2017  9:43250-43257  PubMed ID: 29086563   DOI: 10.1021/acsami.7b14585
10598  Sakagami H, Suzuki R, Shirataki Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Tamura N, Takeshima H.  Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption.  In Vivo  2017  31:1089-1095  PubMed ID: 29102930   DOI: 10.21873/invivo.11174
9461  Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta  Methamphetamine Induces Shati/Nat8L Expression in the Mouse Nucleus Accumbens via CREB- And Dopamine D1 Receptor-Dependent Mechanism  PLoS One  2017  12(3):e0174196  PubMed ID: 28319198   DOI: 10.1371/journal.pone.0174196
12219  Motoshi Komatsubara, Takayuki Hara, Takeshi Hosoya, Kishio Toma, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Kenichi Inagaki, Jun Wada, Fumio Otsuka  Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions  J Steroid Biochem Mol Biol  2017  165(Pt B):182-189  PubMed ID: 27267863   DOI: 10.1016/j.jsbmb.2016.06.002
14383  Tomoko Koda, Jun Takanari, Kentaro Kitadate, Hideki Imai  Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells  Natural Product Communications  2017  12:1934578X1701201    DOI: 10.1177/1934578x1701201027
14483  Sasaki K, Othman MB, Demura M, Watanabe M, Isoda H.  Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii  Front Physiol  2017  8:900  PubMed ID: 29176952   DOI: 10.3389/fphys.2017.00900
14560  Arata Kaneko, , Yuuki Miyazaki, Tatsuya Goto  Transfer-Print of CNTs and its Application to Cell Scaffold  International Journal of Automation Technology  2017  11:941-946    DOI: 10.20965/ijat.2017.p0941
14566  Villareal MO, Ikeya A, Sasaki K, Arfa AB, Neffati M, Isoda H.  Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil  BMC Complement Altern Med  2017  17(1):549  PubMed ID: 29273038   DOI: 10.1186/s12906-017-2060-1
14589  Serien D, Takeuchi S.  Multi-Component Microscaffold With 3D Spatially Defined Proteinaceous Environment  ACS Biomater Sci Eng  2017  3(3):487-494  PubMed ID: 33465943   DOI: 10.1021/acsbiomaterials.6b00695
7102  Yoshida S, Teshima T, Kuribayashi-Shigetomi K, Takeuchi S.  Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells.  Adv Healthc Mater  2016  5:415-20  PubMed ID: 26712104   DOI: 10.1002/adhm.201500782
7131  Saito Y, Ishii KA, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.  Neurochem. Res.  2016  41:696-706  PubMed ID: 26620190   DOI: 10.1007/s11064-015-1738-3
7224  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.  Mol. Neurobiol.  2016  53:4787-97  PubMed ID: 26328540   DOI: 10.1007/s12035-015-9405-x
9623  Seki K, Cueno ME, Kamio N, Saito Y, Kamimoto A, Kurita-Ochiai T, Ochiai K.  Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression.  Apoptosis  2016  21:699-707  PubMed ID: 26994613   DOI: 10.1007/s10495-016-1235-4
9834  Ogra Y, Tejima A, Hatakeyama N, Shiraiwa M, Wu S, Ishikawa T, Yawata A, Anan Y, Suzuki N.  Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.  Sci Rep  2016  6:33007  PubMed ID: 27623342   DOI: 10.1038/srep33007
9848  Mizukami-Murata S, Sakakibara F, Fujita K, Fukuda M, Kuramata M, Takagi K.  Detoxification of hydroxylated polychlorobiphenyls by Sphingomonas sp. strain N-9 isolated from forest soil.  Chemosphere  2016  165:173-182  PubMed ID: 27649311   DOI: 10.1016/j.chemosphere.2016.08.127
9906  Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K.  Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.  Eur. J. Pharmacol.  2016  793:21-27  PubMed ID: 27815170   DOI: 10.1016/j.ejphar.2016.10.037
10856  Fujimura M, Usuki F, Cheng J, Zhao W.  Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum  Toxicol Appl Pharmacol  2016  298:1-8  PubMed ID: 26965727   DOI: 10.1016/j.taap.2016.03.002
10925    Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12  Planta Med Int Open  2016  3: e60–e63    DOI: 10.1055/s-0042-118778
10927  Naoto Ito ; Naoto Konno ; Takashi K. Saito  Sub-micrometer-scale wire-based intracellular metal microelectrode  IEEE Xplore  2016      DOI: 10.1109/MHS.2016.7824199
12904  Shindo Y, Iwamoto K, Mouri K, Hibino K, Tomita M, Kosako H, Sako Y, Takahashi K.  Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling  Nat Commun  2016  7:10485  PubMed ID: 26786866   DOI: 10.1038/ncomms10485
13470  Takito J, Kimura J, Kajima K, Uozumi N, Watanabe M, Yokosuka A, Mimaki Y, Nakamura M, Ohizumi Y.  Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells  Can J Physiol Pharmacol  2016  94(7):728-33.  PubMed ID: 27128150   DOI: 10.1139/cjpp-2015-0394
13979  Ito T, Hayashida M, Kobayashi S, Muto N, Hayashi A, Yoshimura T, Mori H.  Serine racemase is involved in d-aspartate biosynthesis  J Biochem  2016  160(6):345-353  PubMed ID: 27387750   DOI: 10.1093/jb/mvw043
13982  Zeng B, Li Y, Niu B, Wang X, Cheng Y, Zhou Z, You T, Liu Y, Wang H, Xu J.  Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells  J Mol Neurosci  2016  59(4):567-78  PubMed ID: 27412469   DOI: 10.1007/s12031-016-0779-7
14101  Iwori Takeda, Masato Kawanabe, Arata Kaneko  An investigation of cell adhesion and growth on micro/nano-scale structured surface—Self-assembled micro particles as a scaffold  Precision Engineering  2016  43:294-298    DOI: 10.1016/j.precisioneng.2015.08.009
14112  Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K.  Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells  Biochim Biophys Acta  2016  1863(8):1979-84  PubMed ID: 27157538   DOI: 10.1016/j.bbamcr.2016.05.003
14121  Sharma G, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura M, Hisanaga SI.  Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons  Genes Cells  2016  21(10):1080-1094  PubMed ID: 27600567   DOI: 10.1111/gtc.12404
14167  Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Suganuma H, Ushida Y, Yamamoto M, Hashimoto K.  Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice  Sci Rep  2016  ;6:30659  PubMed ID: 27470577   DOI: 10.1038/srep30659
14173  Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K.  Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress  Proc Natl Acad Sci U S A  2016  113(13):E1944-52  PubMed ID: 26976569   DOI: 10.1073/pnas.1601532113
14186  Iwori TAKEDA, Shogo SERIZAWA, Arata KANEKO  Fabrication of micro-structured scaffold using self-assembled particles and effects of surface geometries on cell adhesion  Mechanical Engineering Journal  2016  3:15-00521-15-00521    DOI: 10.1299/mej.15-00521
7123  Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T.  Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy.  Anticancer Res.  2015  35:6431-7  PubMed ID: 26637853  
7160  Jin Y, Tsuchiya A, Kanno T, Nishizaki T.  Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.  Biochem. Biophys. Res. Commun.  2015  468:157-60  PubMed ID: 26522221   DOI: 10.1016/j.bbrc.2015.10.141
7228  Xia B, Liu H, Xie J, Wu R, Li Y.  Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway.  Int. J. Mol. Med.  2015  36:1426-32  PubMed ID: 26324295   DOI: 10.3892/ijmm.2015.2329
7364  Arai Y, Yamamoto T, Minamikawa T, Takamatsu T, Nagai T.  Spectral fingerprinting of individual cells visualized by cavity-reflection-enhanced light-absorption microscopy.  PLoS ONE  2015  10:e0125733  PubMed ID: 25950513   DOI: 10.1371/journal.pone.0125733
7423  Cueno ME, Kamio N, Seki K, Kurita-Ochiai T, Ochiai K.  High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells.  Cell Stress Chaperones  2015  20:709-13  PubMed ID: 25808460   DOI: 10.1007/s12192-015-0584-1
7454  Takeda I, Kawanabe M, Kaneko A.  Autonomous patterning of cells on microstructured fine particles.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259   DOI: 10.1016/j.msec.2015.02.010
7499  Uemura M, Ishiguro H.  Freezing behavior of adherent neuron-like cells and morphological change and viability of post-thaw cells.  Cryobiology  2015  70:122-35  PubMed ID: 25645578   DOI: 10.1016/j.cryobiol.2015.01.006
7527  Florian Larramendy, Daniela Serien, Shotaro Yoshida, Laurent Jalabert, Shoji Takeuchi, Oliver Paul.  High-topography surface functionalization based on parylene-C peel-off for patterned cell growth.  2015 28th IEEE International Conference on MEMS  2015  328-331    DOI: 10.1109/MEMSYS.2015.7050955
7578  Ghimire Gautam S, Komatsu M, Nishigaki K.  Strong inhibition of beta-amyloid peptide aggregation realized by two-steps evolved peptides.  Chem Biol Drug Des  2015  85:356-68  PubMed ID: 25082146   DOI: 10.1111/cbdd.12400
5314  Bahrini I, Song JH, Diez D, Hanayama R.  Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia.  Sci Rep  2015  5:7989  PubMed ID: 25612542   DOI: 10.1038/srep07989
6007  Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K.  Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease.  Biochim Biophys Acta  2015  853(12):3182-91  PubMed ID: 26319097   DOI: 10.1016/j.bbamcr.2015.08.013
9474  Masatake Fujimura, Fusako Usuki  Methylmercury Causes Neuronal Cell Death Through the Suppression of the TrkA Pathway: In Vitro and in Vivo Effects of TrkA Pathway Activators  Toxicol Appl Pharmacol  2015  282(3):259-66  PubMed ID: 25545984   DOI: 10.1016/j.taap.2014.12.008
14970  Ishima T, Futamura T, Ohgi Y, Yoshimi N, Kikuchi T, Hashimoto K.  Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors  Eur Neuropsychopharmacol  2015  25(4):505-11  PubMed ID: 25687838   DOI: 10.1016/j.euroneuro.2015.01.014
15043  Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M.  Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡)  Mar Drugs  2015  13(12):7250-74  PubMed ID: 26690179   DOI: 10.3390/md13127062
15172  Kenta Goto, Tatsuya Suzuki, Hideki Tamai, Junya Ogawa, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Makoto Kiso  Total Synthesis and Neuritogenic Activity Evaluation of Ganglioside PNG-2A from the StarfishProtoreaster nodosus  Asian Journal of Organic Chemistry  2015  4:1160-1171    DOI: 10.1002/ajoc.201500282
15243  Kakinoki S, Seo JH, Inoue Y, Ishihara K, Yui N, Yamaoka T.  Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions  Acta Biomater  2015  13:42-51  PubMed ID: 25463493   DOI: 10.1016/j.actbio.2014.11.020
15481  Fujita S, Ushio S, Ozawa N, Masuguchi K, Kawashiri T, Oishi R, Egashira N.  Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats  PLoS One  2015  10(11):e0141921  PubMed ID: 26536615   DOI: 10.1371/journal.pone.0141921
14964  Yamamoto S, Kawashiri T, Higuchi H, Tsutsumi K, Ushio S, Kaname T, Shirahama M, Egashira N.  Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats  J Pharmacol Sci  2015  129(1):43-50  PubMed ID: 26362518   DOI: 10.1016/j.jphs.2015.08.006
5618  Kudo TA, Kanetaka H, Mochizuki K, Tominami K, Nunome S, Abe G, Kosukegawa H, Abe T, Mori H, Mori K, Takagi T, Izumi S.  Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation  PLoS One  2015  10(4):e0124024  PubMed ID: 25879210   DOI: 10.1371/journal.pone.0124024
7583  Takaaki Mori, Yukihiro Akiyama, Shogo Unuma, Takashi K. Saito.  High performance cell membrane perforation system for cell suspensions.  Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on  2014  1-3    DOI: 10.1109/MHS.2014.7006103
15809  Takahashi K, Yokota M, Ohta T.  Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12  Exp Cell Res  2014  323(2):337-45  PubMed ID: 24630903   DOI: 10.1016/j.yexcr.2014.03.001
15821  Hiromichi NAKADATE, Yohei FUKUMURA, Yuma KANEKO, Akira KAKUTA, Hidenori FURUKAWA, Shigeru AOMURA  In vitro uniaxial stretch model for evaluating the effect of strain along axon on damage to neurons  Journal of Biomechanical Science and Engineering  2014  9:14-00136-14-00136    DOI: 10.1299/jbse.14-00136
15854  Matsui T, Yoshida Y, Yanagihara M, Suenaga H.  Hypothermia at 35 °C reduces the time-dependent microglial production of pro-inflammatory and anti-inflammatory factors that mediate neuronal cell death  Neurocrit Care  2014  20(2):301-10  PubMed ID: 24072458   DOI: 10.1007/s12028-013-9911-5
15855  Kakinoki S, Nakayama M, Moritan T, Yamaoka T.  Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid)  Front Chem  2014  2:52  PubMed ID: 25101261   DOI: 10.3389/fchem.2014.00052
15856  Kakinoki S , Yamaoka T .  Thermoresponsive elastin/laminin mimicking artificial protein for modifying PLLA scaffolds in nerve regeneration  J Mater Chem B  2014  2(31):5061-5067.  PubMed ID: 32261839   DOI: 10.1039/c4tb00305e
15857  Tsuchiya A, Nagaya H, Kanno T, Nishizaki T.  Oleic acid stimulates glucose uptake into adipocytes by enhancing insulin receptor signaling  J Pharmacol Sci  2014  126(4):337-43  PubMed ID: 25391857   DOI: 10.1254/jphs.14182FP
17156  H. Nakadate, S. Aomura, A. Kakuta  An in Vitro Stretch-Injury Model for Elongation-Controlled Neuronal Cells: Effect of Strains Along Neurite  IFMBE Proceedings  2014  756-759    DOI: 10.1007/978-3-319-02913-9_194
15765  Mouri K, Sako Y.  Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells  PLoS Comput Biol  2013  9(11):e1003320  PubMed ID: 24244131   DOI: 10.1371/journal.pcbi.1003320
15929  Shinohara H, Sakai Y, Mir TA.  Real-time monitoring of intracellular signal transduction in PC12 cells by two-dimensional surface plasmon resonance imager  Anal Biochem  2013  441(2):185-9  PubMed ID: 23891634   DOI: 10.1016/j.ab.2013.07.017
15957  Tatsuki SUGIHARA, Arata KANEKO  Self-Patterning of PC12 Cells on Micro-Structures of Protein-Modified Particles  Journal of Solid Mechanics and Materials Engineering  2013  7:142-154    DOI: 10.1299/jmmp.7.142
15959  Tomono S, Yasue Y, Miyoshi N, Ohshima H.  Cytotoxic effects of secosterols and their derivatives on several cultured cells  Biosci Biotechnol Biochem  2013  77(3):651-3  PubMed ID: 23470737   DOI: 10.1271/bbb.120758
15960  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner  Biochem J  2013  450(2):303-9  PubMed ID: 23256752   DOI: 10.1042/BJ20121348
15961  Nishimoto T, Kanno T, Shimizu T, Tanaka A, Nishizaki T.  Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002  Lipids  2013  48(1):23-8  PubMed ID: 23117296   DOI: 10.1007/s11745-012-3736-4
15962  Kouhei Horikawa, Takuya Yagyu, Yukio Yoshioka, Takeshi Fujiwara, Akihiko Kanamoto, Tetsuji Okamoto, Makoto Ojika  Petrosiols A–E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata  Tetrahedron  2013  69:101-106    DOI: 10.1016/j.tet.2012.10.063
15963  Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH.  SLITRK6 mutations cause myopia and deafness in humans and mice  J Clin Invest   2013  123(5):2094-102  PubMed ID: 23543054   DOI: 10.1172/JCI65853
7619  Hoshino T, Saito I, Kometani R, Samejima K, Matsui S, Suzuki T, Mabuchi K, Kato YX.  Improvement of neuronal cell adhesiveness on parylene with oxygen plasma treatment.  J. Biosci. Bioeng.  2012  113:395-8  PubMed ID: 22138385   DOI: 10.1016/j.jbiosc.2011.11.003
7641  Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX.  Neurite outgrowth of PC12 cells on diX (parylene) family materials.  Biotechnol Prog  2012  28:587-90  PubMed ID: 22052685   DOI: 10.1002/btpr.739
7700  Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.  Am. J. Physiol. Endocrinol. Metab.  2012  302:E615-25  PubMed ID: 21878661   DOI: 10.1152/ajpendo.00035.2011
6172  E L Omri A, Han J, Ben Abdrabbah M, Isoda H.  Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells.  Cytotechnology  2012  64(3):231-40  PubMed ID: 21861121   DOI: 10.1007/s10616-011-9352-y
9091  Punnee Nusuetrong, Masaki Saito, Haruhisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, Norimichi Nakahata  Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-Stranded Break in PC12 Cells  J Toxicol Sci  2012  37 (4), 803-12  PubMed ID: 22863859   DOI: 10.2131/jts.37.803
15744  Hiromichi NAKADATE, Hiroto UMAHASHI, Akira KAKUTA, Shigeru AOMURA  Progression to Cell Death Correlates with Neurite Swelling Induced by Stretch Injury  Journal of Biomechanical Science and Engineering  2012  7:406-415    DOI: 10.1299/jbse.7.406
15964  El Omri A, Han J, Kawada K, Ben Abdrabbah M, Isoda H.  Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways  Brain Res  2012  1437:16-25  PubMed ID: 22226506   DOI: 10.1016/j.brainres.2011.12.019
15965  Ishima T, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors  PLoS One  2012  7(5):e37989  PubMed ID: 22655093   DOI: 10.1371/journal.pone.0037989
15966  Masumi Yamada, Sari Sugaya, Yoji Naganuma, Minoru Seki  Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking  Soft Matter  2012  8:3122    DOI: 10.1039/c2sm07263g
15967  Iwori Takeda, Arata Kaneko, Yasuhiro Tanaka, Nobuyuki Moronuki  Selective Cell-Adhesion on Micro-Structured Fine Particles  Key Engineering Materials  2012  516:130-135    DOI: 10.4028/www.scientific.net/kem.516.130
15968  Aita Y, Ishii KA, Saito Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways  Am J Physiol Endocrinol Metab  2012  303(8):E1006-14  PubMed ID: 22912364   DOI: 10.1152/ajpendo.00156.2012
7590  Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T.  [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].  Rinsho Shinkeigaku  2011  51:890-1  PubMed ID: 22277406   DOI: 10.5692/clinicalneurol.51.890
7720  Toda T, Sunagawa T, Kanda T, Tagashira M, Shirasawa T, Shimizu T.  Apple Procyanidins Suppress Amyloid β-Protein Aggregation.  Biochem Res Int  2011  2011:784698  PubMed ID: 21826271   DOI: 10.1155/2011/784698
7737  Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A.  A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease.  Biomicrofluidics  2011  5:22214  PubMed ID: 21799720   DOI: 10.1063/1.3580756
7795  Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T.  Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G230-8  PubMed ID: 21636531   DOI: 10.1152/ajpgi.00436.2009
7803  Sohma Y, Wang H, Taniguchi A, Hirayama Y, Kakizawa T, Yamasaki M, Mukai H, Kiso Y.  Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.  Bioorg. Med. Chem.  2011  19:3787-92  PubMed ID: 21612934   DOI: 10.1016/j.bmc.2011.04.056
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973   DOI: 10.1016/j.febslet.2011.04.056
7889  Hashimoto K, Ishima T.  Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.  PLoS ONE  2011  6:e17431  PubMed ID: 21390260   DOI: 10.1371/journal.pone.0017431
7913  Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.  Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.  Bioorg. Med. Chem.  2011  19:1959-65  PubMed ID: 21345685   DOI: 10.1016/j.bmc.2011.01.059
7923  Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H.  Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform.  Chembiochem  2011  12:795-801  PubMed ID: 21341350   DOI: 10.1002/cbic.201000497
7932  Yabe T, Hosoda-Yabe R, Kanamaru Y, Kiso M.  A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin.  J. Biol. Chem.  2011  286:12397-406  PubMed ID: 21335559   DOI: 10.1074/jbc.M110.172155
7945  Shimizu T, Kanno T, Tanaka A, Nishizaki T.  α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.  Cell. Physiol. Biochem.  2011  27:149-58  PubMed ID: 21325832   DOI: 10.1159/000325217
7965  Onoue S, Kuriyama K, Uchida A, Mizumoto T, Yamada S.  Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.  Pharm. Res.  2011  28:1157-66  PubMed ID: 21287249   DOI: 10.1007/s11095-011-0379-8
8003  Itoh K, Ishima T, Kehler J, Hashimoto K.  Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.  Brain Res.  2011  1377:32-40  PubMed ID: 21211516   DOI: 10.1016/j.brainres.2010.12.075
8020  Shen J, Maruyama IN.  Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.  FEBS Lett.  2011  585:295-9  PubMed ID: 21187090   DOI: 10.1016/j.febslet.2010.12.031
8023  Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO.  The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.  J Ethnopharmacol  2011  134:313-22  PubMed ID: 21172413   DOI: 10.1016/j.jep.2010.12.016
8090  Maezawa Y, Okano K, Matsubara M, Masuhara H, Hosokawa Y.  Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force.  Biomed Microdevices  2011  13:117-22  PubMed ID: 20949320   DOI: 10.1007/s10544-010-9476-4
8097  Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A.  Effects of vibration on differentiation of cultured PC12 cells.  Biotechnol. Bioeng.  2011  108:592-9  PubMed ID: 20939009   DOI: 10.1002/bit.22961
8134  Takadera T, Koriyama Y, Kimura T, Kato S.  5-S-GAD attenuates Fe2+-induced lipid peroxidation and cell death in a neuronal cell model.  Neurotox Res  2011  20:26-31  PubMed ID: 20809179   DOI: 10.1007/s12640-010-9218-7
6146  Shyh‐Chyang Luo Bo Zhu Aiko Nakao Reiko Nakatomi Hsiao‐hua Yu  Functionalized Conducting Polymer Nano‐Networks from Controlled Oxidation Polymerization toward Cell Engineering  Advanced Engineering Materials  2011  13:B423-B427    DOI: 10.1002/adem.201080109
15714  Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K.  Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria  PLoS One  2011  e23684  PubMed ID: 21858208   DOI: 10.1371/journal.pone.0023684
16310  Kudo TA, Kanetaka H, Mizuno K, Ryu Y, Miyamoto Y, Nunome S, Zhang Y, Kano M, Shimizu Y, Hayashi H.  Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway  Genes Cells  2011  16(11):1121-32  PubMed ID: 21988724   DOI: 10.1111/j.1365-2443.2011.01556.x
8030  Hashimoto K, Ishima T.  A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.  PLoS ONE  2010  5:e15430  PubMed ID: 21151481   DOI: 10.1371/journal.pone.0015430
8053  Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K.  Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.  ACS Chem Neurosci  2010  1:747-56  PubMed ID: 22778811   DOI: 10.1021/cn100072e
8057  Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.  Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.  Biosci. Biotechnol. Biochem.  2010  74:2299-306  PubMed ID: 21071836   DOI: 10.1271/bbb.100524
8116  Minase T, Ishima T, Itoh K, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP? receptors.  Eur. J. Pharmacol.  2010  648:67-73  PubMed ID: 20854802   DOI: 10.1016/j.ejphar.2010.09.007
8124  Yaguchi T, Nagata T, Nishizaki T.  1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death.  Behav Brain Funct  2010  6:52  PubMed ID: 20831835   DOI: 10.1186/1744-9081-6-52
8157  Zeng KW, Ko H, Yang HO, Wang XM.  Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.  Neuropharmacology  2010  59:542-50  PubMed ID: 20708632   DOI: 10.1016/j.neuropharm.2010.07.020
8211  Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.  Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.  J. Biosci. Bioeng.  2010  110:572-6  PubMed ID: 20591731   DOI: 10.1016/j.jbiosc.2010.05.013
8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384   DOI: 10.1016/j.jbiosc.2010.02.001
8318  Goto E, Mukozawa M, Mori H, Hara M.  A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth.  J. Biosci. Bioeng.  2010  109:512-8  PubMed ID: 20347776   DOI: 10.1016/j.jbiosc.2009.11.002
8322  Zeng KW, Wang XM, Ko H, Yang HO.  Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells.  J Ethnopharmacol  2010  130:13-8  PubMed ID: 20347949   DOI: 10.1016/j.jep.2010.03.018
8333  Takadera T, Nakajima Y, Kanai Y.  Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:863-8  PubMed ID: 20300959   DOI: 10.1007/s10571-010-9514-z
8392  Oyane A, Tsurushima H, Ito A.  Highly efficient gene transfer system using a laminin-DNA-apatite composite layer.  J Gene Med  2010  12:194-206  PubMed ID: 20082421   DOI: 10.1002/jgm.1425
8405  Yasuyo Maezawa, Yoichiroh Hosokawa, Kazunori Okano, Mie Matsubara and Hiroshi Masuhara  In situ observation of cell-detachment process initiated by femtosecond laser-induced stress wave  Applied Physics A: Materials Science & Processing  2010  101:127-131    DOI: 10.1007/s00339-010-5771-4
8414  Aita Y, Kasahara T, Isobe K, Kawakami Y, Takekoshi K.  Effect of urotensin II on PC12 rat pheochromocytoma cells.  J. Neuroendocrinol.  2010  22:83-91  PubMed ID: 20025629   DOI: 10.1111/j.1365-2826.2009.01944.x
8427  Kakinoki S, Yamaoka T.  Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence.  Acta Biomater  2010  6:1925-30  PubMed ID: 19969110   DOI: 10.1016/j.actbio.2009.12.001
8511  Takadera T, Ohtsuka M, Aoki H.  Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:193-8  PubMed ID: 19688259   DOI: 10.1007/s10571-009-9442-y
15563  Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN.  Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics  Cell  2010  141(5):884-9  PubMed ID: 20493519   DOI: 10.1016/j.cell.2010.03.054
15694  Yuelin ZHANG, Shigeru AOMURA, Kiyoto FURUSE, Akira KAKUTA, Satoshi FUJIWARA, Ayako NASU  Study on Impact Resistance of PC12 Cells  Journal of Biomechanical Science and Engineering  2010  5:119-128    DOI: 10.1299/jbse.5.119
8518  Kato YX, Saito I, Takano H, Mabuchi K, Hoshino T.  Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family.  Neurosci. Lett.  2009  464:26-8  PubMed ID: 19664682   DOI: 10.1016/j.neulet.2009.08.007
8544  Ohnuma K, Toyota T, Ariizumi T, Sugawara T, Asashima M.  Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber.  J. Biosci. Bioeng.  2009  108:76-83  PubMed ID: 19577197   DOI: 10.1016/j.jbiosc.2009.02.020
8556  Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M.  Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway.  J Neural Transm (Vienna)  2009  116:841-52  PubMed ID: 19533291   DOI: 10.1007/s00702-009-0250-9
8647  Ishii T, Uto T, Mori K, Fujikawa R.  Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells.  Life Sci.  2009  84:530-6  PubMed ID: 19230838   DOI: 10.1016/j.lfs.2009.01.025
15697  Atsushi Kira, Kazunori Okano, Yoichiroh Hosokawa, Akira Naito, Koh Fuwa, Jyunpei Yuyama, Hiroshi Masuhara  Micropatterning of perfluoroalkyl self-assembled monolayers for arraying proteins and cells on chips  Applied Surface Science  2009  255:7647-7651    DOI: 10.1016/j.apsusc.2009.04.044
15698  Sumiko Iwasa, Akina Enomoto, Satomi Onoue, Minako Nakai, Takehiko Yajima, Takeshi Fukushima  Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells  Journal of Health Science  2009  55:825-831    DOI: 10.1248/jhs.55.825
16638  Todorova R.  Estimation of methods of protein delivery into mammalian cells--a comparative study by electroporation and bioporter assay  Prikl Biokhim Mikrobiol  2009  45:493-6  PubMed ID: 19764622  
18422  Homma K, Niino Y, Hotta K, Oka K.  Ca(2+) influx through P2X receptors induces actin cytoskeleton reorganization by the formation of cofilin rods in neurites  Mol Cell Neurosci  2008  37(2):261-70  PubMed ID: 17993279   DOI: 10.1016/j.mcn.2007.10.001
18449  Saito M, Shinohara Y, Sasaki H, Netsu Y, Yoshida M, Nakahata N.  Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1//2 in AT1-R-transfected PC12 cells  J Neuroendocrinol  2008  20(3):299-308  PubMed ID: 18208547   DOI: 10.1111/j.1365-2826.2008.01646.x
8723  Shinohara H, Wang F, Hossain SM.  A convenient, high-throughput method for enzyme-luminescence detection of dopamine released from PC12 cells.  Nat Protoc  2008  3:1639-44  PubMed ID: 18833200   DOI: 10.1038/nprot.2008.158
8759  Watanabe S, Wakasugi K.  Zebrafish neuroglobin is a cell-membrane-penetrating globin.  Biochemistry  2008  47:5266-70  PubMed ID: 18416560   DOI: 10.1021/bi800286m
18695  Masuda S, Yamamoto K, Hirabayashi T, Ishikawa Y, Ishii T, Kudo I, Murakami M.  Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival  Biochem J  2008  409(2):429-38  PubMed ID: 17868035   DOI: 10.1042/BJ20070844
18832  Fujikawa H, Kanno T, Nagata T, Nishizaki T.  The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway  Neurosci Lett  2008  448(2):208-11  PubMed ID: 18983890   DOI: 10.1016/j.neulet.2008.10.079
5328  Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T.  Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).  Chem Pharm Bull (Tokyo)  2008  56(1):60-3  PubMed ID: 18175976   DOI: 10.1248/cpb.56.60
10359  Takashi K Saito, Munetoshi Seki, Hitoshi Tabata  Self-organized ZnO Nanorod With Photooxidative Cell Membrane Perforation Enables Large-Scale Cell Manipulation  Anal Bioanal Chem  2008  391(7):2513-9  PubMed ID: 18584155   DOI: 10.1007/s00216-008-2226-2
12792  Nusuetrong P, Pengsuparp T, Meksuriyen D, Tanitsu M, Kikuchi H, Mizugaki M, Shimazu K, Oshima Y, Nakahata N, Yoshida M.  Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells  Biol Pharm Bull   2008  31(6):1115-20  PubMed ID: 18520041   DOI: 10.1248/bpb.31.1115
12793  Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I.  Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4)  Biol Pharm Bull  2008  31(8):1580-4  PubMed ID: 18670092   DOI: 10.1248/bpb.31.1580
16071  Yoichiroh Hosokawa, Yuqiang Jiang, Isamu Oh, Noriko Takizawa, Takayuki Uwada, Kazunori Okano, Hiroshi Masuhara  Femtosecond laser manipulation techniques for individual patterning of biological micro-object  Optical Interactions with Tissue and Cells XIX  2008      DOI: 10.1117/12.762605
16640  Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T.  A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells.  J Neurochem  2008  10:1697-708  PubMed ID: 19014384   DOI: 10.1111/j.1471-4159.2008.05738.x
17117  Noriko Takizawa, Kazunori Okano, Takayuki Uwada, Yoichiroh Hosokawa, Hiroshi Masuhara  Viability evaluation of culture cells patterned by femtosecond laser-induced impulsive force  Optical Interactions with Tissue and Cells XIX  2008      DOI: 10.1117/12.762584
8838  Hiroaki SHINOHARA and Feifei WANG  Real-Time Detection of Dopamine Released from a Nerve Model Cell by an Enzyme-Catalyzed Luminescence Method and Its Application to Drug Assessment  Anal Sci  2007  23:81-84  PubMed ID: 17213629   DOI: 10.2116/analsci.23.81
18619  Seyfried J, Wüllner U.  Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway  Biochem Biophys Res Commun  2007  359(3):759-64  PubMed ID: 17559804   DOI: 10.1016/j.bbrc.2007.05.176
6238  Ishii T, Ishimori H, Mori K, Uto T, Fukuda K, Urashima T, Nishimura M.  Bovine lactoferrin stimulates anchorage-independent cell growth via membrane-associated chondroitin sulfate and heparan sulfate proteoglycans in PC12 cells.  J Pharmacol Sci  2007  104(4):366-73  PubMed ID: 17675795   DOI: 10.1254/jphs.fp0070728
9489  Y Kamata, H Shiraga, A Tai, Y Kawamoto, E Gohda  Induction of Neurite Outgrowth in PC12 Cells by the Medium-Chain Fatty Acid Octanoic Acid  Neuroscience  2007  146(3):1073-81  PubMed ID: 17434686   DOI: 10.1016/j.neuroscience.2007.03.001
9490  T Fukuda, K Ishii, T Nanmoku, K Isobe, Y Kawakami, K Takekoshi  5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside Stimulates Tyrosine Hydroxylase Activity and Catecholamine Secretion by Activation of AMP-activated Protein Kinase in PC12 Cells  J Neuroendocrinol  2007  19(8):621-31  PubMed ID: 17620104   DOI: 10.1111/j.1365-2826.2007.01570.x
10361  Yayoi Murakami, Eriko Aizu-Yokota, Yoshiko Sonoda, Shigeo Ohta, Tadashi Kasahara  Suppression of Endoplasmic Reticulum Stress-Induced Caspase Activation and Cell Death by the Overexpression of Bcl-xL or Bcl-2  J Biochem  2007  141(3):401-10  PubMed ID: 17301078   DOI: 10.1093/jb/mvm044
8867  Ohnuma K, Yomo T, Asashima M, Kaneko K.  Sorting of cells of the same size, shape, and cell cycle stage for a single cell level assay without staining.  BMC Cell Biol.  2006  7:25  PubMed ID: 16790072   DOI: 10.1186/1471-2121-7-25
8909  Hongo S, Watanabe T, Takahashi K, Miyazaki A.  Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation.  J. Cell. Biochem.  2006  98:185-93  PubMed ID: 16408304   DOI: 10.1002/jcb.20763
8918  Takayuki Hoshino, Akinori Ozasa, Reo Kometani, Takafumi Suzuki, Shinji Matsui, and Kunihiko Mabuchi  Development of a regeneration-type neural interface: A microtube guide for axon growth of neuronal cells fabricated using focused-ion-beam chemical vapor deposition  J Vacuum Science & Technology B  2006  24:2538-2543    DOI: 10.1116/1.2359730
8961  Ohnuma K, Hayashi Y, Furue M, Kaneko K, Asashima M.  Serum-free culture conditions for serial subculture of undifferentiated PC12 cells.  J. Neurosci. Methods  2006  151:250-61  PubMed ID: 16169086   DOI: 10.1016/j.jneumeth.2005.08.004
18831  Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site  J Lipid Res  2006  47(6):1146-56  PubMed ID: 16520488   DOI: 10.1194/jlr.M500329-JLR200
5976  Watanabe K, Yaguchi T, Yang D, Kanno T, Nagai K, Yamamoto S, Fujikawa H, Yamamoto H, Nagata T, Tashiro C, Nishizaki T.  Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins.  Cryobiology  2006  53(3):330-5  PubMed ID: 17026979   DOI: 10.1016/j.cryobiol.2006.08.004
6444  Yamazaki M, Chiba K, Mohri T.  Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells.  Neurosci Lett  2006  393(2-3):222-5  PubMed ID: 16239071   DOI: 10.1016/j.neulet.2005.09.068
17372  Takadera T, Yoshikawa R, Ohyashiki T.  Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells  Neurosci Lett  2006  408(2):124-8  PubMed ID: 16982147   DOI: 10.1016/j.neulet.2006.08.066
17373  Syuhei Shigaki, Tatsuhiko Sonoda, Takeyuki Nagashima, Osamu Okitsu, Yasuhiro Kita, Takuro Niidome, Yoshiki Katayama  A new method for evaluation of intracellular protein kinase signals using mass spectrometry  Science and Technology of Advanced Materials  2006  7:699-704    DOI: 10.1016/j.stam.2006.04.015
3186  Masuda, Seiko, Murakami, Makoto, Takanezawa, Yasukazu, Aoki, Junken, Arai, Hiroyuki, Ishikawa, Yukio, Ishii, Toshiharu, Arioka, Manabu, Kudo, Ichiro  Neuronal expression and neuritogenic action of group X secreted phospholipase A2.  J Biol Chem  2005  280:23203-14  PubMed ID: 15781456   DOI: 10.1074/jbc.M500985200
8944  Waki R, Gamo S, Bessho M, Hara M.  Patterning cultured cells by visible light illumination with photosensitizers.  J. Biosci. Bioeng.  2005  100:331-4  PubMed ID: 16243285   DOI: 10.1263/jbb.100.331
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
17367  Fukuda T, Takekoshi K, Nanmoku T, Ishii K, Isobe K, Kawakami Y.  Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells  Biochim Biophys Acta  2005  1726(1):28-33  PubMed ID: 16219424   DOI: 10.1016/j.bbagen.2005.08.008
2717  Ishido M, Masuo Y  Transcriptome of pituitary adenylate cyclase-activating polypeptide-differentiated PC12 cells  Regul Pept  2004  15:15-21  PubMed ID: 15518888   DOI: 10.1016/j.regpep.2004.05.020
2716  Makino N, Sasaki K, Hashida K, Sakakura Y  A metabolic model describing the H2O2 elimination by mammalian cells including H2O2 permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data.  Biochim Biophys Acta  2004  1673:149-59  PubMed ID: 15279886   DOI: 10.1016/j.bbagen.2004.04.011
3184  Shimokawa, Noriaki, Qiu, Chun-Hong, Seki, Takayuki, Dikic, Ivan, Koibuchi, Noriyuki  Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression.  Cell Signal  2004  16:723-9  PubMed ID: 15093613   DOI: 10.1016/j.cellsig.2003.11.005
17353  Muroi Y, Ishii T, Teramoto K, Hori M, Nishimura M.  Calcineurin contributes to the enhancing effect of adenosine on nerve growth factor-induced neurite outgrowth via the decreased duration of p38 mitogen-activated protein kinase phosphorylation  J Pharmacol Sci  2004  95(1):124-31  PubMed ID: 15153659   DOI: 10.1254/jphs.95.124
2647  Rajebhosale M, Greenwood S, Vidugiriene J, Jeromin A, Hilfiker S  Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells  J Biol Chem  2003  278:6075-6084  PubMed ID: 12471042   DOI: 10.1074/jbc.M204702200
3067  Hayashi, Hisaki, Ishisaki, Akira, Imamura, Toru  Smad mediates BMP-2-induced upregulation of FGF-evoked PC12 cell differentiation.  FEBS Lett  2003  536:30-4  PubMed ID: 12586333   DOI: 10.1016/s0014-5793(03)00005-x
9038  Masahiro Nagahama, Shinya Hayashi, Shinsuke Morimitsu, Jun Sakurai  Biological Activities and Pore Formation of Clostridium Perfringens Beta Toxin in HL 60 Cells  J Biol Chem  2003  278 (38), 36934-41  PubMed ID: 12851396   DOI: 10.1074/jbc.M306562200
9593  Xiaohua Zhou, Akihiro Tai, Itaru Yamamoto  Enhancement of Neurite Outgrowth in PC12 Cells Stimulated With Cyclic AMP and NGF by 6-acylated Ascorbic Acid 2-O-alpha-glucosides (6-Acyl-AA-2G), Novel Lipophilic Ascorbate Derivatives  Biol Pharm Bull  2003  26(3):341-6  PubMed ID: 12612444   DOI: 10.1248/bpb.26.341
17316  Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi  Structure of a New Neuritogenic-Active Ganglioside from the Sea Cucumber Stichopus japonicus  European Journal of Organic Chemistry  2003  1004-1008    DOI: 10.1002/ejoc.200390141
2715  Hashida, Kanae, Sakakura, Yuki, Makino, Nobuo  Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase.  Biochim Biophys Acta  2002  1572:85-90  PubMed ID: 12204336   DOI: 10.1016/s0304-4165(02)00282-9
3163  Takezawa, Takezawa, Takenouchi, Takato, Imai, Kei, Takahashi, Toru, Hashizume, Kazuyoshi  Cell culture on thin tissue sections commonly prepared for histopathology.  FASEB J  2002  16:1847-9  PubMed ID: 12223453   DOI: 10.1096/fj.02-0405fje
3007  Nagahama, Masami, Usui, Shihomi, Shinohara, Takashi, Yamaguchi, Tomohiro, Tani, Katsuko, Tagaya, Mitsuo  Inactivation of Galpha(z) causes disassembly of the Golgi apparatus.  J Cell Sci  2002  115:4483-93  PubMed ID: 12414994   DOI: 10.1242/jcs.00093
2641  Saito K. T, Muguruma H, Mabuchi K.  Photodynamic assistance increases the efficiency of the process of microinjection in animal cells.  Biotechnol Lett.  2002  24:309-314    DOI: 10.1023/A:1014072904009
6271  Tanigaki K, Sato T, Tanaka Y, Ochi T, Nishikawa A, Nagai K, Kawashima H, Ohkuma S.  BE-18591 as a new H(+)/Cl(-) symport ionophore that inhibits immunoproliferation and gastritis.  FEBS Lett  2002  524(1-3):37-42  PubMed ID: 12135738   DOI: 10.1016/s0014-5793(02)02996-4
9585  Yuka Suzuki-Mizushima, Eiichi Gohda, Takayuki Okamura, Kayoko Kanasaki, Itaru Yamamoto  Enhancement of NGF- And Cholera Toxin-Induced Neurite Outgrowth by Butyrate in PC12 Cells  Brain Res  2002  951(2):209-17  PubMed ID: 12270499   DOI: 10.1016/s0006-8993(02)03163-3
14334  Takekoshi K, Ishii K, Shibuya S, Kawakami Y, Isobe K, Nakai T.  Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells  Biochem Pharmacol  2002  63(5):977-84  PubMed ID: 11911850   DOI: 10.1016/s0006-2952(01)00862-0
17288  Morimoto A, Irie K, Murakami K, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T.  Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23  Biochem Biophys Res Commun  2002  295(2):306-1  PubMed ID: 12150948   DOI: 10.1016/s0006-291x(02)00670-8
3068  Hayashi H, Ishisaki A, Suzuki M, Imamura T  BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression.  J Cell Sci  2001  114:1387-95  PubMed ID: 11257004   DOI: 10.1242/jcs.114.7.1387
2642  Saito, T K, Takahashi M, Muguruma H, Niki E, Mabuchi K  Phototoxic process after rapid photosensitive membrane damage of 5,5"-bis(aminomethyl)-2,2':5',2"-terthiophene dihydrochloride.  J Photochem Photobiol B  2001  61:114-21  PubMed ID: 11535410   DOI: 10.1016/s1011-1344(01)00167-1
10336  Kasai Y, Ohta T, Nakazato Y, Ito S.  Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1.  J. Vet. Med. Sci.  2001  63:367-72  PubMed ID: 11346169   DOI: 10.1292/jvms.63.367
5979  Matsumoto Y et al   Improvement in the viability of cryopreserved cells by microencapsulation  JSME International Journal Series C Mechanical Systems  2001  44:937-945    DOI: 10.1299/jsmec.44.937
9601  Y Nakayama, Y Aoki, H Niitsu  Studies on the Mechanisms Responsible for the Formation of Focal Swellings on Neuronal Processes Using a Novel in Vitro Model of Axonal Injury  Neurotrauma  2001  18(5):545-54.  PubMed ID: 11393257   DOI: 10.1089/089771501300227341
9602  M Kimura, K I Hidari, T Suzuki, D Miyamoto, Y Suzuki  Engagement of Endogenous Ganglioside GM1a Induces Tyrosine Phosphorylation Involved in Neuron-Like Differentiation of PC12 Cells  Glycobiology   2001  11(4):335-43  PubMed ID: 11358882   DOI: 10.1093/glycob/11.4.335
14336  Yokomatsu T, Takechi H, Akiyama T, Shibuya S, Kominato T, Soeda S, Shimeno H.  Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase  Bioorg Med Chem Lett   2001  11(10):1277-80  PubMed ID: 11392536   DOI: 10.1016/s0960-894x(01)00179-2
15657  Tsuji M, Inanami O, Kuwabara M.  Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway  J Biol Chem  2001  276(35):32779-85  PubMed ID: 11438521   DOI: 10.1074/jbc.M101403200
16910  Tanaka J, Koshimura K, Sohmiya M, Murakami Y, Kato Y.  Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells  Biochem Biophys Res Commun  2001  289(2):358-62  PubMed ID: 11716480   DOI: 10.1006/bbrc.2001.6002
3070  Sassa T, Gomi H, Sun W, Ikeda T, Thompson, R F, Itohara S  Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE.  J Neurochem  2000  74:1809-19  PubMed ID: 10800923   DOI: 10.1046/j.1471-4159.2000.0741809.x
3010  Mashima J, Nagahama M, Hatsuzawa K, Tani K, Horigome T, Yamamoto A, Tagaya M  N-ethylmaleimide-sensitive factor is associated with the nuclear envelope.  Biochem Biophys Res Commun  2000  274:559-64  PubMed ID: 10913377   DOI: 10.1006/bbrc.2000.3162
18649  Saida K, Uchide T, Usui A, Gao XD, Tomizuka N, Oka S, Masuda H.  The endothelin-2/vasoactive intestinal contractor gene: expression and promoter activity in PC12 rat pheochromocytoma cells  J Cardiovasc Pharmacol  2000  ;36(5 Suppl 1):S9-11  PubMed ID: 11078321   DOI: 10.1097/00005344-200036051-00005
5977  Sawada K, Konishi Y, Tominaga M, Watanabe Y, Hirano J, Inoue S, Kageyama R, Blum M, Tominaga A.  Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells.  J Cell Sci  2000  113 ( Pt 15):2705-13  PubMed ID: 10893186   DOI: 10.1242/jcs.113.15.2705
6158  Okui M, Ito F, Ogita K, Kuramoto N, Kudoh J, Shimizu N, Ide T.  Expression of APG-2 protein, a member of the heat shock protein 110 family, in developing rat brain.  Neurochem Int  2000  36(1):35-43  PubMed ID: 10566957   DOI: 10.1016/s0197-0186(99)00095-9
10888  K Takekoshi, K Ishii, K Isobe, F Nomura, T Nammoku, T Nakai  Effects of Natriuretic Peptides (ANP, BNP, CNP) on Catecholamine Synthesis and TH mRNA Levels in PC12 Cells  Life Sci  2000  66(22):PL303-11  PubMed ID: 10834306   DOI: 10.1016/s0024-3205(00)00549-x
10889  K Takekoshi, K Ishii, Y Kawakami, K Isobe, T Nakai  kappa-Opioid Inhibits Catecholamine Biosynthesis in PC12 Rat Pheochromocytoma Cell  FEBS Lett  2000  477(3):273-7  PubMed ID: 10908734   DOI: 10.1016/s0014-5793(00)01789-0
1511  Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T.  Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells  Biochem Biophys Res Commun  2000  274(2):310-5  PubMed ID: 10913336   DOI: 10.1006/bbrc.2000.3137
1908  Koshimura K, Tanaka J, Murakami Y, Kato Y.  Effects of dopamine and L-DOPA on survival of PC12 cells  J Neurosci Res  2000  62(1):112-9  PubMed ID: 11002293   DOI: 10.1002/1097-4547(20001001)62:1<112::AID-JNR12>3.0.CO;2-6
17273  Jianhua Qi, Makoto Ojika, Youji Sakagami  Termitomycesphins A–D, Novel Neuritogenic Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus  Tetrahedron  2000  6:5835-5841    DOI: 10.1016/s0040-4020(00)00548-2
17281  Eguchi T, Kanai S, Kakinuma K, Okazaki T, Mizoue K.  Synthesis of NG-061 and its analogs, and their biological evaluation as an enhancer of nerve growth factor  Chem Pharm Bull (Tokyo)   2000  48(10):1470-3  PubMed ID: 11045453   DOI: 10.1248/cpb.48.1470
2367  Kitani T, Ishida A, Okuno S, Takeuchi M, Kameshita I, Fujisawa H  Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase  J Biochem (Tokyo)  1999  125:1022-1028  PubMed ID: 10348902   DOI: 10.1093/oxfordjournals.jbchem.a022381
6161  Okui M, Ide T, Morita K, Funakoshi E, Ito F, Ogita K, Yoneda Y, Kudoh J, Shimizu N.  High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development.  Genomics  1999  62(2):165-71  PubMed ID: 10610708   DOI: 10.1006/geno.1999.5998
9618  Y Yamauchi, S Hongo, T Ohashi, S Shioda, C Zhou, Y Nakai, N Nishinaka, R Takahashi, F Takeda, M Takeda  Molecular Cloning and Characterization of a Novel Developmentally Regulated Gene, Bdm1, Showing Predominant Expression in Postnatal Rat Brain  Brain Res Mol Brain Res  1999  68(1-2):149-58  PubMed ID: 10320792   DOI: 10.1016/s0169-328x(99)00084-4
15567  Koshimura K, Murakami Y, Sohmiya M, Tanaka J, Kato Y.  Effects of erythropoietin on neuronal activity  J Neurochem  1999  72(6):2565-72  PubMed ID: 10349868   DOI: 10.1046/j.1471-4159.1999.0722565.x
16639  Owada K, Sanjyo N, Kobayashi T, Kamata T, Mizusawa H, Muramatsu H, Muramatsu T, Michikawa M.  Midkine inhibits apoptosis via extracellular signal regulated kinase (ERK) activation in PC12 cells  J Med Dent Sci  1999  46(1):45-51  PubMed ID: 12160213  
17249  Miki Shibahara, Hiroko Isoda, Takehide Murata, Kazunari K. Yokoyama, Tadaatsu Nakahara  Analysis of Glycosphingolipids on Differentiation-Induction of PC12 Pheochromocytoma Cells by Mannosylerythritol Lipid  Animal Cell Technology: Basic & Applied Aspects  1999  329-333    DOI: 10.1007/0-306-46865-4_57
17271  Koshimura K, Tanaka J, Murakami Y, Kato Y.  Enhancement of neuronal survival by 6R-tetrahydrobiopterin  Neuroscience  1999  88(2):561-9  PubMed ID: 10197775   DOI: 10.1016/s0306-4522(98)00199-7
2389  Satoshi Kawatake, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi  Isolation and Structure of a GM3-Type Ganglioside Molecular Species  European Journal of Organic Chemistry  1999  765-769    DOI: 10.1002/(sici)1099-0690(199904)1999:4<765::aid-ejoc765>3.0.co;2-7
2369  Takekoshi K, Nomura F, Isobe K, Motooka M, Nammoku T, Nakai T  Identification and initial characterization of stathmin by the differential display method in nerve growth factor-treated PC12 cells.  Eur J Endocrinol  1998  138:707-12  PubMed ID: 9678541   DOI: 10.1530/eje.0.1380707
3530  Sato N, Wang S, Li L, Okabe K, Hashimoto M, Yaginuma H, Mikoshiba K, Uchiyama Y, Uetsuki T, Yoshikawa K, Milligan CE, Oppenheim RW.  A novel strategy for introducing exogenous bcl-2 into neuronal cells: the Cre/loxP system-mediated activation of bcl-2 for preventing programmed cell death using recombinant adenoviruses.  Mol Cell Neurosci  1998  12(1-2):65-78  PubMed ID: 9770341   DOI: 10.1006/mcne.1998.0703
15577  Tsuneo Takadera, Takao Ohyashiki  Apoptotic cell death and CPP32-like activation induced by thapsigargin and their prevention by nerve growth factor in PC12 cells  Biochimica et Biophysica Acta (BBA) - Molecular Cell Research  1998  1401:63-71  PubMed ID: 9459486   DOI: 10.1016/s0167-4889(97)00116-x
16641  Hiroshi Kuzuya, Hideo Sakamoto, Ko Fujita  Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism  Pteridines  1998  9:39-43    DOI: 10.1515/pteridines.1998.9.1.39
17118  Shimokawa N, Sugama S, Miura M.  Extracellular H+ stimulates the expression of c-fos/c-jun mRNA through Ca2+/calmodulin in PC12 cells  Cell Signal  1998  10(7):499-503  PubMed ID: 9754718   DOI: 10.1016/s0898-6568(97)00176-9
1955  Koshimura K, Murakami Y, Tanaka J, Kato Y.  Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity  J Neurosci Res  1998  54(5):664-72  PubMed ID: 9843157   DOI: 10.1002/(SICI)1097-4547(19981201)54:5<664::AID-JNR11>3.0.CO;2-U
1957  Ling Li, David Prevette, Ronald W. Oppenheim, Carolanne E. Milligan  Involvement of Specific Caspases in Motoneuron Cell Deathin Vivoandin VitroFollowing Trophic Factor Deprivation  Molecular and Cellular Neuroscience  1998  12:157-167  PubMed ID: 9790736   DOI: 10.1006/mcne.1998.0709
2198  Suzuki A  Amyloid beta-protein induces necrotic cell death mediated by ICE cascade in PC12 cells.  Exp Cell Res  1997  234:507-11  PubMed ID: 9260921   DOI: 10.1006/excr.1997.3639
18037  Tomiyama T, Kaneko H, Kataoka Ki, Asano S, Endo N.  Rifampicin inhibits the toxicity of pre-aggregated amyloid peptides by binding to peptide fibrils and preventing amyloid-cell interaction  Biochem J  1997  322 ( Pt 3)(Pt 3):859-65.  PubMed ID: 9148761   DOI: 10.1042/bj3220859
18040  Ishiguro H, Ichino N, Yamada K, Nagatsu T.  Nicotine regulates mRNA level of tyrosine hydroxylase gene but not that of nicotinic acetylcholine receptor genes in PC12 cells  Neurosci Lett  1997  228(1):37-40  PubMed ID: 9197282   DOI: 10.1016/s0304-3940(97)00360-1
18054  Suzuki H, Ikeda K, Furukawa M, Takasaka T.  P2 purinoceptor of the globular substance in the otoconial membrane of the guinea pig inner ear  Am J Physiol  1997  273(5):C1533-40  PubMed ID: 9374638   DOI: 10.1152/ajpcell.1997.273.5.C1533
18062  Katoh S, Mitsui Y, Kitani K, Suzuki T.  Hyperoxia induces the differentiated neuronal phenotype of PC12 cells by producing reactive oxygen species  Biochem Biophys Res Commun  1997  241(2):347-51  PubMed ID: 9425274   DOI: 10.1006/bbrc.1997.7514
18066  Okamoto M, Mori S, Ishimaru M, Tohge H, Nakata Y, Endo H.  An enzyme- linked immunosorbent assay for heparan sulfate proteoglycans  Life Sci  1997  ;60(20):1811-9  PubMed ID: 9150421   DOI: 10.1016/s0024-3205(97)00141-0
12271  J Tanaka, K Koshimura, Y Murakami, M Sohmiya, N Yanaihara, Y Kato  Neuronal protection from apoptosis by pituitary adenylate cyclase-activating polypeptide  Regul Pept  1997  72(1):1-8  PubMed ID: 9404727   DOI: 10.1016/s0167-0115(97)01038-0
17241  Watano T, Hara H, Sukamoto T.  Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells  Jpn J Pharmacol  1997  75(2):209-13  PubMed ID: 9414039   DOI: 10.1254/jjp.75.209
17246  Shuji Kojima, Hiroshi Kugenuma, Sayaka Oyobe, Hiroyuki lizuka, Masahiko Ikekita  Suppressive Effect of Tetrahydrobiopterin on L-β-( 3,4-Dihydroxyphenyl) alanine-Induced Cytotoxicity in PC-12 Cells  Pteridines  1997  8    DOI: 10.1515/pteridines.1997.8.1.10
3015  Tagaya M, Furuno A, Mizushima S  SNAP prevents Mg(2+)-ATP-induced release of N-ethylmaleimide-sensitive factor from the Golgi apparatus in digitonin-permeabilized PC12 cells.  J Biol Chem  1996  271:466-70  PubMed ID: 8550603   DOI: 10.1074/jbc.271.1.466
2056  Shimokawa N, Miura M  Detection of living cells that express AP1 using a fluorolabeled DNA probe.  FEBS Lett  1996  388:16-20  PubMed ID: 8654580   DOI: 10.1016/0014-5793(96)00487-5
2055  Ishizuka T, Sawa K, Kita K, Ino H, Sonoda T, Suzuki N, Tatibana M  Promoter region of the rat phosphoribosylpyrophosphate synthetase-associated protein 39.  Biochim Biophys Acta  1996  1306:34-7  PubMed ID: 8611622   DOI: 10.1016/0167-4781(95)00226-x
2191  Kamata H, Tanaka C, Yagisawa H, Hirata H  Nerve growth factor and forskolin prevent H2O2-induced apoptosis in PC12 cells by glutathione independent mechanism.  Neurosci Lett  1996  212:179-82  PubMed ID: 8843102   DOI: 10.1016/0304-3940(96)12806-8
2190  Kamata H, Tanaka C, Yagisawa H, Matsuda S, Gotoh Y, Nishida E, Hirata H  Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade.  J Biol Chem  1996  271:33018-25  PubMed ID: 8955147   DOI: 10.1074/jbc.271.51.33018
18004  Kitajima I, Kawahara K, Hanyu N, Shin H, Tokioka T, Soejima Y, Tsutsui J, Ozawa M, Shimayama T, Maruyama I.  Enhanced E-cadherin expression and increased calcium-dependent cell-cell adhesion in human T-cell leukemia virus type I Tax-expressing PC12 cells  J Cell Sci  1996  109 ( Pt 3):609-17  PubMed ID: 8907706   DOI: 10.1242/jcs.109.3.609
18005  Miyoshi Y, Date I, Ohmoto T, Iwata H.  Histological analysis of microencapsulated dopamine-secreting cells in agarose/poly(styrene sulfonic acid) mixed gel xenotransplanted into the brain  Exp Neurol  1996  138(1):169-75  PubMed ID: 8593892   DOI: 10.1006/exnr.1996.0055
18012  Matsuzawa A, Murakami M, Atsumi G, Imai K, Prados P, Inoue K, Kudo I.  Release of secretory phospholipase A2 from rat neuronal cells and its possible function in the regulation of catecholamine secretion  Biochem J   1996  ;318 ( Pt 2)(Pt 2):701-9  PubMed ID: 8809065   DOI: 10.1042/bj3180701
18013  Kudo I, Matsuzawa A, Imai K, Murakami M, Inoue K.  Function of type II phospholipase A2 in dopamine secretion by rat neuronal PC12 cells  J Lipid Mediat Cell Signal  1996  14(1-3):25-31  PubMed ID: 8906541   DOI: 10.1016/0929-7855(96)01504-0
6257  Kinoshita K, Waritani T, Noto M, Takizawa K, Minemoto Y, Nishikawa A, Ohkuma S.  Bafilomycin A1 induces apoptosis in PC12 cells independently of intracellular pH.  FEBS Lett  1996  398(1):61-6  PubMed ID: 8946954   DOI: 10.1016/s0014-5793(96)01182-9
1972  Ishizuka T, Ino H, Sawa K, Suzuki N, Tatibana M  Promoter region of the mouse cyclin-dependent kinase 5-encoding gene.  Gene  1995  166:267-71  PubMed ID: 8543173   DOI: 10.1016/0378-1119(95)00650-8
17965  Murasawa S, Matsubara H, Mori Y, Kijima K, Maruyama K, Inada M.  Identification of a negative cis-regulatory element and trans-acting protein that inhibit transcription of the angiotensin II type 1a receptor gene  J Biol Chem  1995  270(41):24282-6  PubMed ID: 7592637   DOI: 10.1074/jbc.270.41.24282
1636  Naito M, Umegaki H, Iguchi A.  Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12  Neurosci Lett  1995  186(2-3):211-3  PubMed ID: 7777199   DOI: 10.1016/0304-3940(95)11321-m
17925  Neuronal differentiation of PC12 cells as a result of prevention of cell death by bcl-2  Neuronal differentiation of PC12 cells as a result of prevention of cell death by bcl-2  J Neurobiol  1994  25(10):1227-34  PubMed ID: 7815055   DOI: 10.1002/neu.480251005
17905  Murasawa S, Matsubara H, Urakami M, Inada M.  Regulatory elements that mediate expression of the gene for the angiotensin II type 1a receptor for the rat  J Biol Chem  1993  268(36):26996-7003.  PubMed ID: 8262935  
6239  Ohkuma S, Shimizu S, Noto M, Sai Y, Kinoshita K, Tamura H.  Inhibition of cell growth by bafilomycin A1, a selective inhibitor of vacuolar H(+)-ATPase.  In Vitro Cell Dev Biol Anim  1993  29A(11):862-6  PubMed ID: 8167902   DOI: 10.1007/bf02631364
1646  Ito M, Maruhashi M, Sakai N, Mizoue K, Hanada K  NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties  J Antibiot (Tokyo)  1992  45:1559-1565  PubMed ID: 1473982   DOI: 10.7164/antibiotics.45.1559
17880  Yanagida M, Gohda E, Yamamoto I.  Dibutyrylcytidine 3',5'-cyclic monophosphate stimulates neurite outgrowth in rat pheochromocytoma PC12  Neurosci Lett  1990  114(3):323-8  PubMed ID: 2169600   DOI: 10.1016/0304-3940(90)90584-v

2975  仲町 英治, 三木 一生, 古川 一憲, 武川 雄一, 土井 哲平  神経細胞に対する力学負荷実験および損傷評価手法の開発  日本機会学会論文集A編  2005  71    DOI: 10.1299/kikaia.71.73

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