CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0009 : PC-12]

1726 Satoh M, Takeuchi M Establishment of HPRT-deficient cell lines from mouse neuroblastoma Neuro-2a and rat pheochromocytoma PC12. Res Commun Inst Ferment 1993 16:6-17 PubMed ID: 7763725

1078 Levi A, Eldridge, J D, Paterson, B M Molecular cloning of a gene sequence regulated by nerve growth factor. Science 1985 229:393-5 PubMed ID: 3839317 DOI: 10.1126/science.3839317

1079 Biocca S, Cattaneo A, Calissano P A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12). EMBO J 1983 2:643-8 PubMed ID: 6641712 DOI: 10.1002/j.1460-2075.1983.tb01478.x

1318 Greene, L A, Tischler, A S Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 1976 73:2424-8 PubMed ID: 1065897 DOI: 10.1073/pnas.73.7.2424

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22111 Tsuji T, Hasegawa J, Sasaki T, Fujimoto T. Definition of phosphatidylinositol 4,5-bisphosphate distribution by freeze-fracture replica labeling. J Cell Biol 2025 224(1) PubMed ID: 39495319 DOI: 10.1083/jcb.202311067

22502 Itaya T, Takagi S, Kamiya T, Nakazawa K, Katagiri S, Suzuki T. The Pharmaceutical Composition of Rocuronium Bromide May Promote Catecholamine Release From PC-12 Cells. Cureus 2025 16(12):e76537 PubMed ID: 39872597 DOI: 10.7759/cureus.76537

22978 Asaba T, Osaki T, Murayama K, Hamano S, Kageyama T, Fukuda J. Effects of vascular endothelial cells on the neurite outgrowth of nerve cells. J Biosci Bioeng 2025 PubMed ID: 40527656 DOI: 10.1016/j.jbiosc.2025.05.010

21545 Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K. Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice. PLoS One 2024 19(1):e0296750 PubMed ID: 38181010 DOI: 10.1371/journal.pone.0296750

21558 Mochizuki R, Ogra Y. Determination of intracellular dopamine by liquid chromatography-fluorescence detection with post-column derivatization using the König reaction. J Chromatogr B Analyt Technol Biomed Life Sci 2024 1232:123956 PubMed ID: 38128164 DOI: 10.1016/j.jchromb.2023.123956

21590 Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, Inoue A, Maruyama T, Kudo TA, Hirata Y, Shindo S, Uchida Y, Hwang GW, Matsuzawa A. Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. Cell Death Discov 2024 10(1):74 PubMed ID: 38346947 DOI: 10.1038/s41420-024-01838-2

21719 Chuma S, Kiyosue K, Akiyama T, Kinoshita M, Shimazaki Y, Uchiyama S, Sotoma S, Okabe K, Harada Y. Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature. Nat Commun 2024 15(1):3473 PubMed ID: 38724563 DOI: 10.1038/s41467-024-47542-8

21922 Ayaka Mori, Taichi Shiroishi, Jun Fujioka, Takashi Nakajima, Shinichi Mitsui, Hinaho Suginoma, Yohei Kakuta, Heishun Zen, Kazuhiro Nakamura Infrared free electron laser-irradiated polyleucine does not exert aggregates-induced aversive effects on mouse brain Brain Disorders 2024 14:100137 DOI: 10.1016/j.dscb.2024.100137

22116 Li S, Takada S, Abdel-Salam GMH, Abdel-Hamid MS, Zaki MS, Issa MY, Salem AMS, Koshimizu E, Fujita A, Fukai R, Ohshima T, Matsumoto N, Miyake N. Biallelic loss-of-function variants in GON4L cause microcephaly and brain structure abnormalities. NPJ Genom Med 2024 9(1):55 PubMed ID: 39500882 DOI: 10.1038/s41525-024-00437-5

22685 Nakazawa K, Matsuo M, Kikuchi Y, Nakajima Y, Numano R. Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock Front Neurosci 2024 18:1186677 PubMed ID: 38694901 DOI: 10.3389/fnins.2024.1186677

22809 Yuki Enoki, Yuki Kanezaki, Isamu Takahata, Kazuaki Taguchi, Kazuaki Matsumoto Betulinic acid ameliorates cast‐immobilized skeletal muscle atrophy but not denervation‐induced skeletal muscle atrophy JCSM Communications 2024 7:30-39 DOI: 10.1002/rco2.89

22889 Soejima Y, Iwata N, Yamamoto K, Suyama A, Nakano Y, Otsuka F. Mutual Effects of Orexin and Bone Morphogenetic Proteins on Catecholamine Regulation Using Adrenomedullary Cells Int J Mol Sci 2024 25(3):1585 PubMed ID: 38338864 DOI: 10.3390/ijms25031585

22890 Nagashima D, Mizukami N, Ogawa N, Suzuki S, Ohno M, Aoki R, Furukawa M, Izumo N. Bovine Lactoferrin Promotes Neurite Outgrowth in PC12 Cells via the TrkA Receptor Int J Mol Sci 2024 25(20):11249 PubMed ID: 39457031 DOI: 10.3390/ijms252011249

19538 Okami H, Kawaharada R, Yoshizaki H, Toriumi A, Tsutsumi S, Nakamura A. Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model Nutrients 2023 15(15):3434 PubMed ID: 37571372 DOI: 10.3390/nu15153434

19564 Sasayama Y, Mamiya T, Qi J, Shibata T, Uchida K, Nabeshima T, Ojika M. Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-acceler Bioorg Med Chem 2023 78:117144 PubMed ID: 36577328 DOI: 10.1016/j.bmc.2022.117144

19648 Florence Hui Ping Tan, Andrew Chung Jie Ting, Nazalan Najimudin, Nobumoto Watanabe, Shaharum Shamsuddin, Azalina Zainuddin, Hiroyuki Osada, Ghows Azzam 3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer’s Disease Drosophila The Journals of Gerontology: Series A 2023 78:1944-1952 DOI: 10.1093/gerona/glad169

19657 Mochizuki R, Kobayashi A, Takayama H, Toida T, Ogra Y. Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction Anal Methods 2023 15(28):3426-3431 PubMed ID: 37427721 DOI: 10.1039/d3ay00860f

19920 Tan FHP, Najimudin N, Watanabe N, Shamsuddin S, Azzam G. p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model Behav Brain Res 2023 452:114568 PubMed ID: 37414223 DOI: 10.1016/j.bbr.2023.114568

20949 Chua P, Lim WK. The strategic uses of collagen in adherent cell cultures. Cell Biol Int 2023 47(2):367-373 PubMed ID: 36423248 DOI: 10.1002/cbin.11966

20995 Kiya R, Tang T, Tanaka Y, Hosokawa Y, Yalikun Y. Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser. Sci Rep 2023 13(1):405 PubMed ID: 36624119 DOI: 10.1038/s41598-022-27229-0

21075 Shibato J, Takenoya F, Yamashita M, Gupta R, Min CW, Kim ST, Kimura A, Takasaki I, Hori M, Shioda S, Rakwal R. OMICS Analyses Unraveling Related Gene and Protein-Driven Molecular Mechanisms Underlying PACAP 38-Induced Neurite Outgrowth in PC12 Cells. Int J Mol Sci 2023 24(4) PubMed ID: 36835581 DOI: 10.3390/ijms24044169

21139 Ikemoto MJ, Aihara Y, Ishii N, Shigemori H. 3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells. Biol Pharm Bull 2023 46(4):599-607 PubMed ID: 37005304 DOI: 10.1248/bpb.b22-00727

21190 Yoshinaga N, Tateishi A, Kobayashi Y, Kubo T, Miyakawa H, Satoh K, Numata K. Effect of Oligomers Derived from Biodegradable Polyesters on Eco- and Neurotoxicity. Biomacromolecules 2023 PubMed ID: 37085155 DOI: 10.1021/acs.biomac.3c00160

21359 Nakamura M, Araki H, Tsurushima H, Oyane A. Fabrication of water-dispersible and cell-stimulating calcium phosphate nanoparticles immobilizing basic fibroblast growth factor. Colloids Surf B Biointerfaces 2023 230:113502 PubMed ID: 37574618 DOI: 10.1016/j.colsurfb.2023.113502

21393 Okumura H, Itoh SG, Zen H, Nakamura K. Dissociation process of polyalanine aggregates by free electron laser irradiation. PLoS One 2023 18(9):e0291093 PubMed ID: 37683014 DOI: 10.1371/journal.pone.0291093

21549 Tomita K, Oohara Y, Igarashi K, Kitanaka J, Kitanaka N, Tanaka KI, Roudkenar MH, Roushandeh AM, Sugimura M, Sato T. Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice. Heliyon 2023 9(12):e22784 PubMed ID: 38090003 DOI: 10.1016/j.heliyon.2023.e22784

17505 Owada R, Mitsui S, Nakamura K. Exogenous polyserine and polyleucine are toxic to recipient cells Sci Rep 2022 12(1):1685 PubMed ID: 35102230 DOI: 10.1038/s41598-022-05720-y

17513 Jamal M, Tsukamoto I, Maki T, Takei S, Konishi R, Kinoshita H. COA-Cl Evokes Protective Responses Against H2O2-and 6-OHDA-Induced Toxic Injury in PC12 Cells Neurotox Res 2022 40(6):2061-2071 PubMed ID: 36435924 DOI: 10.1007/s12640-022-00587-3

17535 Daichi Nagashima, Chisa Matsubara, Noa Mizukami, Akane Nakagawa, Megumi Furukawa, Masahiro Toho, Ryoken Aoki, Yasuo Watanabe and Nobuo Izumo Effect of Coriander on H2O2-induced Oxidative Stress in PC12 Cells Journal of Clinical and Medical Research 2022 DOI: 10.37191/mapsci-2582-4333-4(3)-115

17684 Luo YR, Kudo TA, Tominami K, Izumi S, Tanaka T, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G, Wang H. SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells Int J Mol Sci 2022 23(24):15602 PubMed ID: 36555248 DOI: 10.3390/ijms232415602

17937 Morimoto E, Inagaki K, Komatsubara M, Terasaka T, Itoh Y, Fujisawa S, Sasaki E, Nishiyama Y, Hara T, Wada J. Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells J Endocr Soc 2022 6(10):bvac121 PubMed ID: 36042979 DOI: 10.1210/jendso/bvac121

20405 Uchida M, Ushio S, Niimura T, Takechi K, Kawazoe H, Hidaka N, Tanaka A, Araki H, Zamami Y, Ishizawa K, Kitamura Y, Sendou T, Kawasaki H, Namba H, Shibata K, Tanaka M, Takatori S. Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation. Biol Pharm Bull 2022 PubMed ID: 34803077 DOI: 10.1248/bpb.b21-00852

20499 Tomita K, Yamanishi-Taira S, Igarashi K, Oogai Y, Kuwahara Y, Roudkenar MH, Roushandeh AM, Miyawaki S, Kurimasa A, Sato T. Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells. Peptides 2022 170734 PubMed ID: 34974081 DOI: 10.1016/j.peptides.2021.170734

20648 Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H. Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives. Int J Mol Sci 2022 23(5) PubMed ID: 35269748 DOI: 10.3390/ijms23052601

20919 Owada R, Kakuta Y, Yoshida K, Mitsui S, Nakamura K. Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice. Sci Rep 2022 12(1):18718 PubMed ID: 36333586 DOI: 10.1038/s41598-022-23571-5

20958 Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M, Funato H. Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature 2022 PubMed ID: 36477539 DOI: 10.1038/s41586-022-05450-1

21026 Shinagawa T, Miyata S. Three-Dimensional Cell Drawing Technique in Hydrogel Using Micro Injection System. Micromachines (Basel) 2022 13(11) PubMed ID: 36363885 DOI: 10.3390/mi13111866

21146 Koga T, Tai A. Neurite Outgrowth-Promoting Compounds from Cockscomb Hydrolysate. Nutrients 2022 14(7) PubMed ID: 35406035 DOI: 10.3390/nu14071422

22321 Hatayama M, Katayama KI, Kawahara Y, Matsunaga H, Takashima N, Iwayama Y, Matsumoto Y, Nishi A, Yoshikawa T, Aruga J. SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex Commun Biol 2022 5(1):935 PubMed ID: 36085162 DOI: 10.1038/s42003-022-03891-y

13538 Oguro A, Ishihara Y, Siswanto FM, Yamazaki T, Ishida A, Imaishi H, Imaoka S. Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease Biochim Biophys Acta Mol Cell Biol Lipids 2021 1866(2):158858 PubMed ID: 33279658 DOI: 10.1016/j.bbalip.2020.158858

20109 Chua P, Lim WK. Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents. Sci Rep 2021 PubMed ID: 33854099 DOI: 10.1038/s41598-021-87431-4

14195 Zhang T, Namoto M, Okano K, Akita E, Teranishi N, Tang T, Anggraini D, Hao Y, Tanaka Y, Inglis D, Yalikun Y, Li M, Hosokawa Y. Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers Sci Rep 2021 11(1):1652 PubMed ID: 33462348 DOI: 10.1038/s41598-021-81190-y

20171 Ando E, Higashi S, Mizokami A, Watanabe S, Hirata M, Takeuchi H. Osteocalcin promotes proliferation, differentiation, and survival of PC12 cells. Biochem Biophys Res Commun 2021 557:174-179 PubMed ID: 33865226 DOI: 10.1016/j.bbrc.2021.03.146

20333 Liang Y, Ueno M, Zha S, Okimura T, Jiang Z, Yamaguchi K, Hatakeyama T, Oda T. Sulfated polysaccharide ascophyllan prevents amyloid fibril formation of human insulin and inhibits amyloid-induced hemolysis and cytotoxicity in PC12 cells. Biosci Biotechnol Biochem 2021 PubMed ID: 34519773 DOI: 10.1093/bbb/zbab163

20463 Iizuka Y, Owada R, Kawasaki T, Hayashi F, Sonoyama M, Nakamura K. Toxicity of internalized polyalanine to cells depends on aggregation. Sci Rep 2021 11(1):23441 PubMed ID: 34873226 DOI: 10.1038/s41598-021-02889-6

16041 Tan FHP, Hadri NAB, Najimudin N, Watanabe N, Azzam G. Ethyl caffeate ameliorated amyloid-beta42 protein-associated toxicity in PC12 cells and Drosophila melanogaster Geriatr Gerontol Int 2021 21(12):1125-1130 PubMed ID: 34699118 DOI: 10.1111/ggi.14296

16234 Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, Azzam G. Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease J Ethnopharmacol 2021 8;279:114389 PubMed ID: 34217797 DOI: 10.1016/j.jep.2021.114389

16426 Li Xiao, Feng Liao, Yumei Fan, Nobuhiko Miwa Ren Shen Yang Rong Tang and other traditional Chinese medicines exhibit antioxidant and anti-inflammatory capacities and suppress acetylcholinesterase activity in PC12 neuronal cells Longhua Chinese Medicine 2021 4:13-13 DOI: 10.21037/lcm-21-12

20757 Shibato J, Takenoya F, Hirabayashi T, Kimura A, Yamashita M, Takasaki I, Rakwal R, Shioda S. Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells. Neural Plast 2021 2522454 PubMed ID: 34422037 DOI: 10.1155/2021/2522454

16796 Honda A, Hayasaka O, Mio K, Fujimura K, Kotani T, Komatsu M, Shiozaki K. The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis Biochimie 2021 185:105-116 PubMed ID: 33746065 DOI: 10.1016/j.biochi.2021.03.008

17754 Yamaguchi K, Mitsunaga T, Yamauchi K. 6-Paradol and its glucoside improve memory disorder in mice Food Funct 2020 11(11):9892-9902 PubMed ID: 33094793 DOI: 10.1039/d0fo01975e

11760 Hsu YI, Yamaoka T. Improved exposure of bioactive peptides to the outermost surface of the polylactic acid nanofiber scaffold. J. Biomed. Mater. Res. Part B Appl. Biomater. 2020 108(4):1274-1280. PubMed ID: 31429188 DOI: 10.1002/jbm.b.34475

11937 Usuki T, Yoshimoto Y, Sato M, Takenaka T, Takezawa R, Yoshida Y, Satake M, Suzuki N, Hashizume D, Dzyuba SV. Bilobalide and PC12 cells: A structure activity relationship study. Bioorg. Med. Chem. 2020 PubMed ID: 31848115 DOI: 10.1016/j.bmc.2019.115251

12037 Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H. Modification of TRPV4 activity by acetaminophen. Heliyon 2020 PubMed ID: 32051870 DOI: 10.1016/j.heliyon.2020.e03301

13077 Xiao L, Liao F, Ide R, Horie T, Fan Y, Saiki C, Miwa N. Enzyme-digested Colla Corii Asini (E'jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells. Neural Regen Res 2020 PubMed ID: 32594048 DOI: 10.4103/1673-5374.285000

13093 Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H. Protection of Bortezomib-induced Neurotoxicity by Antioxidants. Anticancer Res 2020 PubMed ID: 32620607 DOI: 10.21873/anticanres.14357

13120 Tanaka N, Okuda M, Nishigaki T, Tsuchiya N, Kobayashi Y, Uemura T, Kumo S, Sugimoto H, Miyata S, Waku T. Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins. PLoS One 2020 PubMed ID: 32706773 DOI: 10.1371/journal.pone.0235979

13177 Nishimura A, Suwabe R, Ogihara Y, Yoshida S, Abe H, Osawa SI, Nakagawa A, Tominaga T, Nishizawa M. Totally transparent hydrogel-based subdural electrode with patterned salt bridge. Biomed Microdevices 2020 PubMed ID: 32827271 DOI: 10.1007/s10544-020-00517-0

13208 Owada R, Awata S, Suzue K, Kanetaka H, Kakuta Y, Nakamura K. Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells. Heliyon 2020 PubMed ID: 32954034 DOI: 10.1016/j.heliyon.2020.e04851

13366 Kobayashi Y, Oguro A, Yagi E, Mitani A, Kudoh SN, Imaoka S. Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells. J Toxicol Sci 2020 PubMed ID: 33268678 DOI: 10.2131/jts.45.783

13555 Koga T, Sakamoto T, Sakuradani E, Tai A. Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds Molecules 2020 25(20):4748 PubMed ID: 33081156 DOI: 10.3390/molecules25204748

13596 Rascher M, Wittstein K, Winter B, Rupcic Z, Wolf-Asseburg A, Stadler M, Köster RW. Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction Biomolecules 2020 10(10):1440 PubMed ID: 33066380 DOI: 10.3390/biom10101440

13642 Ikegami Y, Ijima H. Development of heparin-conjugated nanofibers and a novel biological signal by immobilized growth factors for peripheral nerve regeneration J Biosci Bioeng 2020 129(3):354-362 PubMed ID: 31601468 DOI: 10.1016/j.jbiosc.2019.09.004

13896 Madoka IMURA, Soichiro YAMADA, Koji YAMAMOTO, Yusuke MORITA, Eiji NAKAMACHI Development of a three-dimensional cell culture system for the enhancement of nerve axonal extension by cyclic stretch stimulation Journal of Biomechanical Science and Engineering 2020 15(4):20 DOI: 10.1299/jbse.20-00094

13942 Eiji NAKAMACHI, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA, Manabu OKITA Development of a three-dimensional direct current electric field stimulation bioreactor to enhance the axonal outgrowth and control the axonal orientation Journal of Biomechanical Science and Engineering 2020 15:19-00480 DOI: 10.1299/jbse.19-00480

14848 Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y. Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study Molecules 2020 25(18):420 PubMed ID: 32937854 DOI: 10.3390/molecules25184206

21797 Kudo TA, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Hong G, Nakai J. Characterization of PC12 Cell Subclones with Different Sensitivities to Programmed Thermal Stimulation Int J Mol Sci 2020 21(21):8356 PubMed ID: 33171774 DOI: 10.3390/ijms21218356

11262 Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H. COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis. Brain Res. 2019 PubMed ID: 30366020 DOI: 10.1016/j.brainres.2018.10.026

11287 Nishizaki T. Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death. Mol. Neurobiol. 2019 56(7):4812-4819 PubMed ID: 30402707 DOI: 10.1007/s12035-018-1408-y

11420 Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y. Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate. Bioorg. Med. Chem. 2019 PubMed ID: 30733085 DOI: 10.1016/j.bmc.2019.01.038

11406 Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Okano Y, Masaki H. 3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress. Exp. Dermatol. 2019 PubMed ID: 30698879 DOI: 10.1111/exd.13820

11488 Matsushima Y, Terada K, Kamei C, Sugimoto Y. Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor. Eur. J. Pharmacol. 2019 PubMed ID: 30902656 DOI: 10.1016/j.ejphar.2019.03.032

4318 Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y. Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells. Biosci. Biotechnol. Biochem. 2019 PubMed ID: 30543144 DOI: 10.1080/09168451.2018.1553607

11658 Aruto Hori, Yuki Watabe, Masumi Yamada, Yuya Yajima, Rie Utoh, Minoru Seki One-Step Formation of Microporous Hydrogel Sponges Encapsulating Living Cells by Utilizing Bicontinuous Dispersion of Aqueous Polymer Solutions ACS Appl. Bio Mater. 2019 PubMed ID: 35030662 DOI: 10.1021/acsabm.9b00194

11812 Matsuzaki Y, Maruta R, Takaki K, Kotani E, Kato Y, Yoshimura R, Endo Y, Whitty C, Pernstich C, Gandhi R, Jones M, Mori H. Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells. Biomolecules 2019 PubMed ID: 31546991 DOI: 10.3390/biom9100510

9494 Keisuke Migita, Taichi Matsumoto, Kazuki Terada, Kazuhiko Ono, Shuji Hara Effects of Geldanamycin on Neurite Outgrowth-Related Proteins and Kinases in Nerve Growth Factor-Differentiated Pheochromocytoma 12 Cells J Pharmacol Sci 2019 140(3):255-262 PubMed ID: 31402210 DOI: 10.1016/j.jphs.2019.07.011

10509 Eiji NAKAMACHI, Ryota SAKIYAMA, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA Enhancement of nerve axonal extension by an AC magnetic field stimulation bio-reactor using three-dimensional culture Journal of Biomechanical Science and Engineering 2019 14(2) DOI: 10.1299/jbse.19-00041

12153 Takanobu Haccho, Atsuru Kanno, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System Plasma Medicine 2019 DOI: 10.1615/PlasmaMed.2020033059

12300 Florian Larramendy, Shotaro Yoshida, Daniela Maier, Zoltan Fekete, Shoji Takeuchi, Oliver Paul 3D arrays of microcages by two-photon lithography for spatial organization of living cells Lab Chip 2019 19(5):875-884 PubMed ID: 30723853 DOI: 10.1039/c8lc01240g

12328 Ikeda T, Ichikawa K, Shigeto H, Ishida T, Hirota R, Funabashi H, Kuroda A. Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish Biosci Biotechnol Biochem 2019 83(12):2272-2275 PubMed ID: 31482750 DOI: 10.1080/09168451.2019.1659716

12361 Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I. Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy J Neurochem 2019 148(3):373-385 PubMed ID: 30295925 DOI: 10.1111/jnc.14607

12550 Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M. Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs Medchemcomm 2019 0(7):1121-1125 PubMed ID: 31391884 DOI: 10.1039/c9md00011a

12552 Masukawa D, Yamada K, Goshima Y. Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibits neurite outgrowth in PC12 cells J Pharmacol Sci 2019 141(1):41-48 PubMed ID: 31606330 DOI: 10.1016/j.jphs.2019.09.002

22043 Sarma SN, Nagano R, Ohsako S. Tyroxine Hydroxylase-Positive Neuronal Cell Population is Increased by Temporal Dioxin Exposure at Early Stage of Differentiation from Human Embryonic Stem Cells. Int J Mol Sci 2019 20(11) PubMed ID: 31159217 DOI: 10.3390/ijms20112687

10415 Mizukami-Murata S, Fujita K, Nakano T. Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells. Environ Sci Pollut Res Int 2018 25(17):16434-16445 PubMed ID: 28695493 DOI: 10.1007/s11356-017-9604-2

10540 Terada K, Matsushima Y, Matsunaga K, Takata J, Karube Y, Ishige A, Chiba K. The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. Bosn J Basic Med Sci 2018 18(3):224-233 PubMed ID: 28961087 DOI: 10.17305/bjbms.2017.2248

10615 Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M. Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice. Eur. J. Pharmacol. 2018 819:35-42 PubMed ID: 29154935 DOI: 10.1016/j.ejphar.2017.11.024

10699 Murata T, Yamaguchi M, Kohno S, Takahashi C, Kakimoto M, Sugimura Y, Kamihara M, Hikita K, Kaneda N. Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells. FEBS Open Bio 2018 8:349-360 PubMed ID: 29511612 DOI: 10.1002/2211-5463.12374

10765 Sakagami H, Tsuji M, Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T, Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui T, Oizumi H, Oizumi T. Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder. In Vivo 2018 32:231-239 PubMed ID: 29475904 DOI: 10.21873/invivo.11229

11111 Sakagami H, Hara Y, Shi H, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells. In Vivo 2018 32(4):765-770 PubMed ID: 29936457 DOI: 10.21873/invivo.11306

11143 Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K. Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells. Neurosci. Lett. 2018 685:42-4 PubMed ID: 30044955 DOI: 10.1016/j.neulet.2018.07.031

11215 Oguro A, Inoue T, Kudoh SN, Imaoka S. 14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells. Pharmacol Res Perspect 2018 PubMed ID: 30237892 DOI: 10.1002/prp2.428

11214 Koh I, Furusawa K, Haga H. Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells. Sci Rep 2018 PubMed ID: 30224813 DOI: 10.1038/s41598-018-32156-0

11110 Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T. Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants. In Vivo 2018 32(4):745-752 PubMed ID: 29936454 DOI: 10.21873/invivo.11303

11255 Sano A, Shi H, Suzuki R, Shirataki Y, Sakagami H. Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells. In Vivo 2018 PubMed ID: 30348694 DOI: 10.21873/invivo.11392

11277 Nishizaki T. Profilin facilitates PKCε activation by accelerating ATP supply. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30392913 DOI: 10.1016/j.bbrc.2018.10.114

11344 Terada K, Migita K, Matsushima Y, Sugimoto Y, Kamei C, Matsumoto T, Mori M, Matsunaga K, Takata J, Karube Y. Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. PLoS ONE 2018 PubMed ID: 30557385 DOI: 10.1371/journal.pone.0209250

4436 Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation The Japan Society of Mechanical Engineers 2018 13,18-00024-18-00024 DOI: 10.1299/jbse.18-00024

4315 Sun Z, Liu Y, Kong X, Wang R, Xu Y, Shang C, Huo J, Huang M, Zhao F, Bian K, Zhang S, Tu Y, Chen X. Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2. Cell. Physiol. Biochem. 2018 PubMed ID: 29794460 DOI: 10.1159/000490017

4316 Sakagami H, Shi H, Bandow K, Tomomura M, Tomomura A, Horiuchi M, Fujisawa T, Oizumi T. Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method. Molecules 2018 PubMed ID: 30042342 DOI: 10.3390/molecules23081840

4317 Nishizaki T. IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway. Heliyon 2018 PubMed ID: 30533546 DOI: 10.1016/j.heliyon.2018.e00971

4381 Ohta M, Chosa N, Kyakumoto S, Yokota S, Okubo N, Nemoto A, Kamo M, Joh S, Satoh K, Ishisaki A. IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals. Int. J. Mol. Med. 2018 42(3):1484-1494 PubMed ID: 29901090 DOI: 10.3892/ijmm.2018.3714

4495 Masami Ishido An Overview of Development of Quantitative Neurotoxicity Testing In vitro Journal of Applied Life Sciences International 2018 19(2):1-9 DOI: 10.9734/JALSI/2018/45377

12549 Hsing‐An Lin, Bo Zhu, Yu‐Wei Wu, Jun Sekine, Aiko Nakao, Shyh‐Chyang Luo, Yoshiro Yamashita, Hsiao‐Hua Yu Dynamic Poly(3,4‐ethylenedioxythiophene)s Integrate Low Impedance with Redox‐Switchable Biofunction Advanced Functional Materials 2018 28 DOI: 10.1002/adfm.201703890

14539 Takanobu Haccho, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi Development of Chemotherapy System Using Plasma Activated Medium to Enhance PC12 Axonal Extension Biomedical and Biotechnology Engineering 2018 3 DOI: 10.1115/imece2018-86630

14543 Mizuki Fujiwara, Kyoichi Ono, Takashi K. Saito Photo-Oxidative Cell Membrane Perforation and Applied Cellular Level Neural Interface and Electrophysiological Recording in Animal Cells 2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS) 2018 DOI: 10.1109/mhs.2018.8886985

9769 Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H. GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells. J. Cell. Biochem. 2017 118:699-708 PubMed ID: 27463736 DOI: 10.1002/jcb.25662

9780 Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI. Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death. J. Antibiot. 2017 70:429-434 PubMed ID: 27507633 DOI: 10.1038/ja.2016.99

10129 Hozumi Y, Fujiwara H, Kaneko K, Fujii S, Topham MK, Watanabe M, Goto K. Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells. Cell Tissue Res. 2017 368:441-458 PubMed ID: 28191598 DOI: 10.1007/s00441-017-2579-y

10182 Mir TA, Shinohara H. Two-Dimensional Surface Plasmon Resonance Imaging System for Cellular Analysis. Methods Mol. Biol. 2017 1571:31-46 PubMed ID: 28281248 DOI: 10.1007/978-1-4939-6848-0_3

10391 Shinsuke K, Junya K, Tomonobu U, Yoshiko K, Izumo N, Takahiko S. Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation. J. Radiat. Res. 2017 58:809-815 PubMed ID: 29106600 DOI: 10.1093/jrr/rrx032

10485 Takahashi N, Onozuka W, Watanabe S, Wakasugi K. Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth. FEBS Open Bio 2017 7:1338-1349 PubMed ID: 28904863 DOI: 10.1002/2211-5463.12271

10511 Okutani C, Wagatsuma A, Mabuchi K, Hoshino T. Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering. Conf Proc IEEE Eng Med Biol Soc 2017 2017:1607-1610 PubMed ID: 29060190 DOI: 10.1109/EMBC.2017.8037146

10513 Muroi T, Matsushima Y, Kanamori R, Inoue H, Fujii W, Yogo K. GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice. Reproduction 2017 154:755-764 PubMed ID: 28912303 DOI: 10.1530/REP-17-0333

10591 Tachizawa S, Takahashi H, Kim YJ, Odawara A, Pauty J, Ikeuchi Y, Suzuki I, Kikuchi A, Matsunaga YT. Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding. ACS Appl Mater Interfaces 2017 9:43250-43257 PubMed ID: 29086563 DOI: 10.1021/acsami.7b14585

10598 Sakagami H, Suzuki R, Shirataki Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Tamura N, Takeshima H. Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption. In Vivo 2017 31:1089-1095 PubMed ID: 29102930 DOI: 10.21873/invivo.11174

9461 Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta Methamphetamine Induces Shati/Nat8L Expression in the Mouse Nucleus Accumbens via CREB- And Dopamine D1 Receptor-Dependent Mechanism PLoS One 2017 12(3):e0174196 PubMed ID: 28319198 DOI: 10.1371/journal.pone.0174196

12219 Motoshi Komatsubara, Takayuki Hara, Takeshi Hosoya, Kishio Toma, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Kenichi Inagaki, Jun Wada, Fumio Otsuka Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions J Steroid Biochem Mol Biol 2017 165(Pt B):182-189 PubMed ID: 27267863 DOI: 10.1016/j.jsbmb.2016.06.002

14383 Tomoko Koda, Jun Takanari, Kentaro Kitadate, Hideki Imai Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells Natural Product Communications 2017 12:1934578X1701201 DOI: 10.1177/1934578x1701201027

14483 Sasaki K, Othman MB, Demura M, Watanabe M, Isoda H. Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii Front Physiol 2017 8:900 PubMed ID: 29176952 DOI: 10.3389/fphys.2017.00900

14560 Arata Kaneko, , Yuuki Miyazaki, Tatsuya Goto Transfer-Print of CNTs and its Application to Cell Scaffold International Journal of Automation Technology 2017 11:941-946 DOI: 10.20965/ijat.2017.p0941

14566 Villareal MO, Ikeya A, Sasaki K, Arfa AB, Neffati M, Isoda H. Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil BMC Complement Altern Med 2017 17(1):549 PubMed ID: 29273038 DOI: 10.1186/s12906-017-2060-1

14589 Serien D, Takeuchi S. Multi-Component Microscaffold With 3D Spatially Defined Proteinaceous Environment ACS Biomater Sci Eng 2017 3(3):487-494 PubMed ID: 33465943 DOI: 10.1021/acsbiomaterials.6b00695

7102 Yoshida S, Teshima T, Kuribayashi-Shigetomi K, Takeuchi S. Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells. Adv Healthc Mater 2016 5:415-20 PubMed ID: 26712104 DOI: 10.1002/adhm.201500782

7131 Saito Y, Ishii KA, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K. Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization. Neurochem. Res. 2016 41:696-706 PubMed ID: 26620190 DOI: 10.1007/s11064-015-1738-3

7224 Kanno T, Tsuchiya A, Tanaka A, Nishizaki T. Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation. Mol. Neurobiol. 2016 53:4787-97 PubMed ID: 26328540 DOI: 10.1007/s12035-015-9405-x

9623 Seki K, Cueno ME, Kamio N, Saito Y, Kamimoto A, Kurita-Ochiai T, Ochiai K. Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression. Apoptosis 2016 21:699-707 PubMed ID: 26994613 DOI: 10.1007/s10495-016-1235-4

9834 Ogra Y, Tejima A, Hatakeyama N, Shiraiwa M, Wu S, Ishikawa T, Yawata A, Anan Y, Suzuki N. Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons. Sci Rep 2016 6:33007 PubMed ID: 27623342 DOI: 10.1038/srep33007

9848 Mizukami-Murata S, Sakakibara F, Fujita K, Fukuda M, Kuramata M, Takagi K. Detoxification of hydroxylated polychlorobiphenyls by Sphingomonas sp. strain N-9 isolated from forest soil. Chemosphere 2016 165:173-182 PubMed ID: 27649311 DOI: 10.1016/j.chemosphere.2016.08.127

9906 Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K. Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression. Eur. J. Pharmacol. 2016 793:21-27 PubMed ID: 27815170 DOI: 10.1016/j.ejphar.2016.10.037

10856 Fujimura M, Usuki F, Cheng J, Zhao W. Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum Toxicol Appl Pharmacol 2016 298:1-8 PubMed ID: 26965727 DOI: 10.1016/j.taap.2016.03.002

10925 Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12 Planta Med Int Open 2016 3: e60–e63 DOI: 10.1055/s-0042-118778

10927 Naoto Ito ; Naoto Konno ; Takashi K. Saito Sub-micrometer-scale wire-based intracellular metal microelectrode IEEE Xplore 2016 DOI: 10.1109/MHS.2016.7824199

12904 Shindo Y, Iwamoto K, Mouri K, Hibino K, Tomita M, Kosako H, Sako Y, Takahashi K. Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling Nat Commun 2016 7:10485 PubMed ID: 26786866 DOI: 10.1038/ncomms10485

13470 Takito J, Kimura J, Kajima K, Uozumi N, Watanabe M, Yokosuka A, Mimaki Y, Nakamura M, Ohizumi Y. Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells Can J Physiol Pharmacol 2016 94(7):728-33. PubMed ID: 27128150 DOI: 10.1139/cjpp-2015-0394

13979 Ito T, Hayashida M, Kobayashi S, Muto N, Hayashi A, Yoshimura T, Mori H. Serine racemase is involved in d-aspartate biosynthesis J Biochem 2016 160(6):345-353 PubMed ID: 27387750 DOI: 10.1093/jb/mvw043

13982 Zeng B, Li Y, Niu B, Wang X, Cheng Y, Zhou Z, You T, Liu Y, Wang H, Xu J. Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells J Mol Neurosci 2016 59(4):567-78 PubMed ID: 27412469 DOI: 10.1007/s12031-016-0779-7

14101 Iwori Takeda, Masato Kawanabe, Arata Kaneko An investigation of cell adhesion and growth on micro/nano-scale structured surface—Self-assembled micro particles as a scaffold Precision Engineering 2016 43:294-298 DOI: 10.1016/j.precisioneng.2015.08.009

14112 Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K. Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells Biochim Biophys Acta 2016 1863(8):1979-84 PubMed ID: 27157538 DOI: 10.1016/j.bbamcr.2016.05.003

14121 Sharma G, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura M, Hisanaga SI. Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons Genes Cells 2016 21(10):1080-1094 PubMed ID: 27600567 DOI: 10.1111/gtc.12404

14167 Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Suganuma H, Ushida Y, Yamamoto M, Hashimoto K. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice Sci Rep 2016 ;6:30659 PubMed ID: 27470577 DOI: 10.1038/srep30659

14173 Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K. Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress Proc Natl Acad Sci U S A 2016 113(13):E1944-52 PubMed ID: 26976569 DOI: 10.1073/pnas.1601532113

14186 Iwori TAKEDA, Shogo SERIZAWA, Arata KANEKO Fabrication of micro-structured scaffold using self-assembled particles and effects of surface geometries on cell adhesion Mechanical Engineering Journal 2016 3:15-00521-15-00521 DOI: 10.1299/mej.15-00521

7123 Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T. Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy. Anticancer Res. 2015 35:6431-7 PubMed ID: 26637853

7160 Jin Y, Tsuchiya A, Kanno T, Nishizaki T. Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage. Biochem. Biophys. Res. Commun. 2015 468:157-60 PubMed ID: 26522221 DOI: 10.1016/j.bbrc.2015.10.141

7228 Xia B, Liu H, Xie J, Wu R, Li Y. Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway. Int. J. Mol. Med. 2015 36:1426-32 PubMed ID: 26324295 DOI: 10.3892/ijmm.2015.2329

7364 Arai Y, Yamamoto T, Minamikawa T, Takamatsu T, Nagai T. Spectral fingerprinting of individual cells visualized by cavity-reflection-enhanced light-absorption microscopy. PLoS ONE 2015 10:e0125733 PubMed ID: 25950513 DOI: 10.1371/journal.pone.0125733

7423 Cueno ME, Kamio N, Seki K, Kurita-Ochiai T, Ochiai K. High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells. Cell Stress Chaperones 2015 20:709-13 PubMed ID: 25808460 DOI: 10.1007/s12192-015-0584-1

7454 Takeda I, Kawanabe M, Kaneko A. Autonomous patterning of cells on microstructured fine particles. Mater Sci Eng C Mater Biol Appl 2015 50:173-8 PubMed ID: 25746259 DOI: 10.1016/j.msec.2015.02.010

7499 Uemura M, Ishiguro H. Freezing behavior of adherent neuron-like cells and morphological change and viability of post-thaw cells. Cryobiology 2015 70:122-35 PubMed ID: 25645578 DOI: 10.1016/j.cryobiol.2015.01.006

7527 Florian Larramendy, Daniela Serien, Shotaro Yoshida, Laurent Jalabert, Shoji Takeuchi, Oliver Paul. High-topography surface functionalization based on parylene-C peel-off for patterned cell growth. 2015 28th IEEE International Conference on MEMS 2015 328-331 DOI: 10.1109/MEMSYS.2015.7050955

7578 Ghimire Gautam S, Komatsu M, Nishigaki K. Strong inhibition of beta-amyloid peptide aggregation realized by two-steps evolved peptides. Chem Biol Drug Des 2015 85:356-68 PubMed ID: 25082146 DOI: 10.1111/cbdd.12400

5314 Bahrini I, Song JH, Diez D, Hanayama R. Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia. Sci Rep 2015 5:7989 PubMed ID: 25612542 DOI: 10.1038/srep07989

6007 Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K. Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease. Biochim Biophys Acta 2015 853(12):3182-91 PubMed ID: 26319097 DOI: 10.1016/j.bbamcr.2015.08.013

9474 Masatake Fujimura, Fusako Usuki Methylmercury Causes Neuronal Cell Death Through the Suppression of the TrkA Pathway: In Vitro and in Vivo Effects of TrkA Pathway Activators Toxicol Appl Pharmacol 2015 282(3):259-66 PubMed ID: 25545984 DOI: 10.1016/j.taap.2014.12.008

14970 Ishima T, Futamura T, Ohgi Y, Yoshimi N, Kikuchi T, Hashimoto K. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors Eur Neuropsychopharmacol 2015 25(4):505-11 PubMed ID: 25687838 DOI: 10.1016/j.euroneuro.2015.01.014

15043 Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M. Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡) Mar Drugs 2015 13(12):7250-74 PubMed ID: 26690179 DOI: 10.3390/md13127062

15172 Kenta Goto, Tatsuya Suzuki, Hideki Tamai, Junya Ogawa, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Makoto Kiso Total Synthesis and Neuritogenic Activity Evaluation of Ganglioside PNG-2A from the StarfishProtoreaster nodosus Asian Journal of Organic Chemistry 2015 4:1160-1171 DOI: 10.1002/ajoc.201500282

15243 Kakinoki S, Seo JH, Inoue Y, Ishihara K, Yui N, Yamaoka T. Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions Acta Biomater 2015 13:42-51 PubMed ID: 25463493 DOI: 10.1016/j.actbio.2014.11.020

15481 Fujita S, Ushio S, Ozawa N, Masuguchi K, Kawashiri T, Oishi R, Egashira N. Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats PLoS One 2015 10(11):e0141921 PubMed ID: 26536615 DOI: 10.1371/journal.pone.0141921

14964 Yamamoto S, Kawashiri T, Higuchi H, Tsutsumi K, Ushio S, Kaname T, Shirahama M, Egashira N. Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats J Pharmacol Sci 2015 129(1):43-50 PubMed ID: 26362518 DOI: 10.1016/j.jphs.2015.08.006

5618 Kudo TA, Kanetaka H, Mochizuki K, Tominami K, Nunome S, Abe G, Kosukegawa H, Abe T, Mori H, Mori K, Takagi T, Izumi S. Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation PLoS One 2015 10(4):e0124024 PubMed ID: 25879210 DOI: 10.1371/journal.pone.0124024

7583 Takaaki Mori, Yukihiro Akiyama, Shogo Unuma, Takashi K. Saito. High performance cell membrane perforation system for cell suspensions. Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on 2014 1-3 DOI: 10.1109/MHS.2014.7006103

19179 Ogasawara J, Ito T, Wakame K, Kitadate K, Sakurai T, Sato S, Ishibashi Y, Izawa T, Takahashi K, Ishida H, Takabatake I, Kizaki T, Ohno H. ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells Nat Prod Commun 2014 9(4):561-4 PubMed ID: 24868884

19221 Koizumi K, Nakajima H. Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway Biomed Rep 2014 2(1):29-33 PubMed ID: 24649064 DOI: 10.3892/br.2013.203

15809 Takahashi K, Yokota M, Ohta T. Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12 Exp Cell Res 2014 323(2):337-45 PubMed ID: 24630903 DOI: 10.1016/j.yexcr.2014.03.001

15821 Hiromichi NAKADATE, Yohei FUKUMURA, Yuma KANEKO, Akira KAKUTA, Hidenori FURUKAWA, Shigeru AOMURA In vitro uniaxial stretch model for evaluating the effect of strain along axon on damage to neurons Journal of Biomechanical Science and Engineering 2014 9:14-00136-14-00136 DOI: 10.1299/jbse.14-00136

15854 Matsui T, Yoshida Y, Yanagihara M, Suenaga H. Hypothermia at 35 °C reduces the time-dependent microglial production of pro-inflammatory and anti-inflammatory factors that mediate neuronal cell death Neurocrit Care 2014 20(2):301-10 PubMed ID: 24072458 DOI: 10.1007/s12028-013-9911-5

15855 Kakinoki S, Nakayama M, Moritan T, Yamaoka T. Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid) Front Chem 2014 2:52 PubMed ID: 25101261 DOI: 10.3389/fchem.2014.00052

15856 Kakinoki S , Yamaoka T . Thermoresponsive elastin/laminin mimicking artificial protein for modifying PLLA scaffolds in nerve regeneration J Mater Chem B 2014 2(31):5061-5067. PubMed ID: 32261839 DOI: 10.1039/c4tb00305e

15857 Tsuchiya A, Nagaya H, Kanno T, Nishizaki T. Oleic acid stimulates glucose uptake into adipocytes by enhancing insulin receptor signaling J Pharmacol Sci 2014 126(4):337-43 PubMed ID: 25391857 DOI: 10.1254/jphs.14182FP

17156 H. Nakadate, S. Aomura, A. Kakuta An in Vitro Stretch-Injury Model for Elongation-Controlled Neuronal Cells: Effect of Strains Along Neurite IFMBE Proceedings 2014 756-759 DOI: 10.1007/978-3-319-02913-9_194

19411 Sasaki K, El Omri A, Kondo S, Han J, Isoda H. Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation Behav Brain Res 2013 238:86-94 PubMed ID: 23085339 DOI: 10.1016/j.bbr.2012.10.010

15765 Mouri K, Sako Y. Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells PLoS Comput Biol 2013 9(11):e1003320 PubMed ID: 24244131 DOI: 10.1371/journal.pcbi.1003320

15929 Shinohara H, Sakai Y, Mir TA. Real-time monitoring of intracellular signal transduction in PC12 cells by two-dimensional surface plasmon resonance imager Anal Biochem 2013 441(2):185-9 PubMed ID: 23891634 DOI: 10.1016/j.ab.2013.07.017

15957 Tatsuki SUGIHARA, Arata KANEKO Self-Patterning of PC12 Cells on Micro-Structures of Protein-Modified Particles Journal of Solid Mechanics and Materials Engineering 2013 7:142-154 DOI: 10.1299/jmmp.7.142

15959 Tomono S, Yasue Y, Miyoshi N, Ohshima H. Cytotoxic effects of secosterols and their derivatives on several cultured cells Biosci Biotechnol Biochem 2013 77(3):651-3 PubMed ID: 23470737 DOI: 10.1271/bbb.120758

15960 Kanno T, Tsuchiya A, Tanaka A, Nishizaki T. The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner Biochem J 2013 450(2):303-9 PubMed ID: 23256752 DOI: 10.1042/BJ20121348

15961 Nishimoto T, Kanno T, Shimizu T, Tanaka A, Nishizaki T. Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002 Lipids 2013 48(1):23-8 PubMed ID: 23117296 DOI: 10.1007/s11745-012-3736-4

15962 Kouhei Horikawa, Takuya Yagyu, Yukio Yoshioka, Takeshi Fujiwara, Akihiko Kanamoto, Tetsuji Okamoto, Makoto Ojika Petrosiols A–E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata Tetrahedron 2013 69:101-106 DOI: 10.1016/j.tet.2012.10.063

15963 Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH. SLITRK6 mutations cause myopia and deafness in humans and mice J Clin Invest 2013 123(5):2094-102 PubMed ID: 23543054 DOI: 10.1172/JCI65853

7619 Hoshino T, Saito I, Kometani R, Samejima K, Matsui S, Suzuki T, Mabuchi K, Kato YX. Improvement of neuronal cell adhesiveness on parylene with oxygen plasma treatment. J. Biosci. Bioeng. 2012 113:395-8 PubMed ID: 22138385 DOI: 10.1016/j.jbiosc.2011.11.003

7641 Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX. Neurite outgrowth of PC12 cells on diX (parylene) family materials. Biotechnol Prog 2012 28:587-90 PubMed ID: 22052685 DOI: 10.1002/btpr.739

7700 Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K. Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD. Am. J. Physiol. Endocrinol. Metab. 2012 302:E615-25 PubMed ID: 21878661 DOI: 10.1152/ajpendo.00035.2011

6172 E L Omri A, Han J, Ben Abdrabbah M, Isoda H. Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells. Cytotechnology 2012 64(3):231-40 PubMed ID: 21861121 DOI: 10.1007/s10616-011-9352-y

9091 Punnee Nusuetrong, Masaki Saito, Haruhisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, Norimichi Nakahata Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-Stranded Break in PC12 Cells J Toxicol Sci 2012 37 (4), 803-12 PubMed ID: 22863859 DOI: 10.2131/jts.37.803

15744 Hiromichi NAKADATE, Hiroto UMAHASHI, Akira KAKUTA, Shigeru AOMURA Progression to Cell Death Correlates with Neurite Swelling Induced by Stretch Injury Journal of Biomechanical Science and Engineering 2012 7:406-415 DOI: 10.1299/jbse.7.406

15964 El Omri A, Han J, Kawada K, Ben Abdrabbah M, Isoda H. Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways Brain Res 2012 1437:16-25 PubMed ID: 22226506 DOI: 10.1016/j.brainres.2011.12.019

15965 Ishima T, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors PLoS One 2012 7(5):e37989 PubMed ID: 22655093 DOI: 10.1371/journal.pone.0037989

15966 Masumi Yamada, Sari Sugaya, Yoji Naganuma, Minoru Seki Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking Soft Matter 2012 8:3122 DOI: 10.1039/c2sm07263g

15967 Iwori Takeda, Arata Kaneko, Yasuhiro Tanaka, Nobuyuki Moronuki Selective Cell-Adhesion on Micro-Structured Fine Particles Key Engineering Materials 2012 516:130-135 DOI: 10.4028/www.scientific.net/kem.516.130

15968 Aita Y, Ishii KA, Saito Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K. Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways Am J Physiol Endocrinol Metab 2012 303(8):E1006-14 PubMed ID: 22912364 DOI: 10.1152/ajpendo.00156.2012

7590 Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T. [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23]. Rinsho Shinkeigaku 2011 51:890-1 PubMed ID: 22277406 DOI: 10.5692/clinicalneurol.51.890

7720 Toda T, Sunagawa T, Kanda T, Tagashira M, Shirasawa T, Shimizu T. Apple Procyanidins Suppress Amyloid β-Protein Aggregation. Biochem Res Int 2011 2011:784698 PubMed ID: 21826271 DOI: 10.1155/2011/784698

7737 Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A. A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease. Biomicrofluidics 2011 5:22214 PubMed ID: 21799720 DOI: 10.1063/1.3580756

7795 Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T. Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2011 301:G230-8 PubMed ID: 21636531 DOI: 10.1152/ajpgi.00436.2009

7803 Sohma Y, Wang H, Taniguchi A, Hirayama Y, Kakizawa T, Yamasaki M, Mukai H, Kiso Y. Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors. Bioorg. Med. Chem. 2011 19:3787-92 PubMed ID: 21612934 DOI: 10.1016/j.bmc.2011.04.056

7817 Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N. Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl. FEBS Lett. 2011 585:1741-7 PubMed ID: 21570973 DOI: 10.1016/j.febslet.2011.04.056

7889 Hashimoto K, Ishima T. Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. PLoS ONE 2011 6:e17431 PubMed ID: 21390260 DOI: 10.1371/journal.pone.0017431

7913 Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M. Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds. Bioorg. Med. Chem. 2011 19:1959-65 PubMed ID: 21345685 DOI: 10.1016/j.bmc.2011.01.059

7923 Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H. Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform. Chembiochem 2011 12:795-801 PubMed ID: 21341350 DOI: 10.1002/cbic.201000497

7932 Yabe T, Hosoda-Yabe R, Kanamaru Y, Kiso M. A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin. J. Biol. Chem. 2011 286:12397-406 PubMed ID: 21335559 DOI: 10.1074/jbc.M110.172155

7945 Shimizu T, Kanno T, Tanaka A, Nishizaki T. α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers. Cell. Physiol. Biochem. 2011 27:149-58 PubMed ID: 21325832 DOI: 10.1159/000325217

7965 Onoue S, Kuriyama K, Uchida A, Mizumoto T, Yamada S. Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity. Pharm. Res. 2011 28:1157-66 PubMed ID: 21287249 DOI: 10.1007/s11095-011-0379-8

8003 Itoh K, Ishima T, Kehler J, Hashimoto K. Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors. Brain Res. 2011 1377:32-40 PubMed ID: 21211516 DOI: 10.1016/j.brainres.2010.12.075

8020 Shen J, Maruyama IN. Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells. FEBS Lett. 2011 585:295-9 PubMed ID: 21187090 DOI: 10.1016/j.febslet.2010.12.031

8023 Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO. The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease. J Ethnopharmacol 2011 134:313-22 PubMed ID: 21172413 DOI: 10.1016/j.jep.2010.12.016

8090 Maezawa Y, Okano K, Matsubara M, Masuhara H, Hosokawa Y. Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force. Biomed Microdevices 2011 13:117-22 PubMed ID: 20949320 DOI: 10.1007/s10544-010-9476-4

8097 Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A. Effects of vibration on differentiation of cultured PC12 cells. Biotechnol. Bioeng. 2011 108:592-9 PubMed ID: 20939009 DOI: 10.1002/bit.22961

8134 Takadera T, Koriyama Y, Kimura T, Kato S. 5-S-GAD attenuates Fe2+-induced lipid peroxidation and cell death in a neuronal cell model. Neurotox Res 2011 20:26-31 PubMed ID: 20809179 DOI: 10.1007/s12640-010-9218-7

6146 Shyh‐Chyang Luo Bo Zhu Aiko Nakao Reiko Nakatomi Hsiao‐hua Yu Functionalized Conducting Polymer Nano‐Networks from Controlled Oxidation Polymerization toward Cell Engineering Advanced Engineering Materials 2011 13:B423-B427 DOI: 10.1002/adem.201080109

15714 Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K. Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria PLoS One 2011 e23684 PubMed ID: 21858208 DOI: 10.1371/journal.pone.0023684

16310 Kudo TA, Kanetaka H, Mizuno K, Ryu Y, Miyamoto Y, Nunome S, Zhang Y, Kano M, Shimizu Y, Hayashi H. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway Genes Cells 2011 16(11):1121-32 PubMed ID: 21988724 DOI: 10.1111/j.1365-2443.2011.01556.x

8030 Hashimoto K, Ishima T. A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI. PLoS ONE 2010 5:e15430 PubMed ID: 21151481 DOI: 10.1371/journal.pone.0015430

8053 Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K. Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23. ACS Chem Neurosci 2010 1:747-56 PubMed ID: 22778811 DOI: 10.1021/cn100072e

8057 Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T. Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model. Biosci. Biotechnol. Biochem. 2010 74:2299-306 PubMed ID: 21071836 DOI: 10.1271/bbb.100524

8116 Minase T, Ishima T, Itoh K, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP? receptors. Eur. J. Pharmacol. 2010 648:67-73 PubMed ID: 20854802 DOI: 10.1016/j.ejphar.2010.09.007

8124 Yaguchi T, Nagata T, Nishizaki T. 1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death. Behav Brain Funct 2010 6:52 PubMed ID: 20831835 DOI: 10.1186/1744-9081-6-52

8157 Zeng KW, Ko H, Yang HO, Wang XM. Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology 2010 59:542-50 PubMed ID: 20708632 DOI: 10.1016/j.neuropharm.2010.07.020

8211 Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J. Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device. J. Biosci. Bioeng. 2010 110:572-6 PubMed ID: 20591731 DOI: 10.1016/j.jbiosc.2010.05.013

8234 Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J. Cell micropatterning inside a microchannel and assays under a stable concentration gradient. J. Biosci. Bioeng. 2010 110:230-7 PubMed ID: 20547384 DOI: 10.1016/j.jbiosc.2010.02.001

8318 Goto E, Mukozawa M, Mori H, Hara M. A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth. J. Biosci. Bioeng. 2010 109:512-8 PubMed ID: 20347776 DOI: 10.1016/j.jbiosc.2009.11.002

8322 Zeng KW, Wang XM, Ko H, Yang HO. Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells. J Ethnopharmacol 2010 130:13-8 PubMed ID: 20347949 DOI: 10.1016/j.jep.2010.03.018

8333 Takadera T, Nakajima Y, Kanai Y. Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. Cell. Mol. Neurobiol. 2010 30:863-8 PubMed ID: 20300959 DOI: 10.1007/s10571-010-9514-z

8392 Oyane A, Tsurushima H, Ito A. Highly efficient gene transfer system using a laminin-DNA-apatite composite layer. J Gene Med 2010 12:194-206 PubMed ID: 20082421 DOI: 10.1002/jgm.1425

8405 Yasuyo Maezawa, Yoichiroh Hosokawa, Kazunori Okano, Mie Matsubara and Hiroshi Masuhara In situ observation of cell-detachment process initiated by femtosecond laser-induced stress wave Applied Physics A: Materials Science & Processing 2010 101:127-131 DOI: 10.1007/s00339-010-5771-4

8414 Aita Y, Kasahara T, Isobe K, Kawakami Y, Takekoshi K. Effect of urotensin II on PC12 rat pheochromocytoma cells. J. Neuroendocrinol. 2010 22:83-91 PubMed ID: 20025629 DOI: 10.1111/j.1365-2826.2009.01944.x

8427 Kakinoki S, Yamaoka T. Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence. Acta Biomater 2010 6:1925-30 PubMed ID: 19969110 DOI: 10.1016/j.actbio.2009.12.001

8511 Takadera T, Ohtsuka M, Aoki H. Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells. Cell. Mol. Neurobiol. 2010 30:193-8 PubMed ID: 19688259 DOI: 10.1007/s10571-009-9442-y

19187 Tanaka A, Hamada N, Fujita Y, Itoh T, Nozawa Y, Iinuma M, Ito M. A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation Bioorg Med Chem 2010 18(9):3133-9 PubMed ID: 20371185 DOI: 10.1016/j.bmc.2010.03.034

3732 Niino Y, Hotta K, Oka K. Blue fluorescent cGMP sensor for multiparameter fluorescence imaging PLoS One 2010 5(2):e9164 PubMed ID: 20161796 DOI: 10.1371/journal.pone.0009164

15563 Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics Cell 2010 141(5):884-9 PubMed ID: 20493519 DOI: 10.1016/j.cell.2010.03.054

15694 Yuelin ZHANG, Shigeru AOMURA, Kiyoto FURUSE, Akira KAKUTA, Satoshi FUJIWARA, Ayako NASU Study on Impact Resistance of PC12 Cells Journal of Biomechanical Science and Engineering 2010 5:119-128 DOI: 10.1299/jbse.5.119

8518 Kato YX, Saito I, Takano H, Mabuchi K, Hoshino T. Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family. Neurosci. Lett. 2009 464:26-8 PubMed ID: 19664682 DOI: 10.1016/j.neulet.2009.08.007

8544 Ohnuma K, Toyota T, Ariizumi T, Sugawara T, Asashima M. Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber. J. Biosci. Bioeng. 2009 108:76-83 PubMed ID: 19577197 DOI: 10.1016/j.jbiosc.2009.02.020

8556 Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M. Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway. J Neural Transm (Vienna) 2009 116:841-52 PubMed ID: 19533291 DOI: 10.1007/s00702-009-0250-9

8647 Ishii T, Uto T, Mori K, Fujikawa R. Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells. Life Sci. 2009 84:530-6 PubMed ID: 19230838 DOI: 10.1016/j.lfs.2009.01.025

15697 Atsushi Kira, Kazunori Okano, Yoichiroh Hosokawa, Akira Naito, Koh Fuwa, Jyunpei Yuyama, Hiroshi Masuhara Micropatterning of perfluoroalkyl self-assembled monolayers for arraying proteins and cells on chips Applied Surface Science 2009 255:7647-7651 DOI: 10.1016/j.apsusc.2009.04.044

15698 Sumiko Iwasa, Akina Enomoto, Satomi Onoue, Minako Nakai, Takehiko Yajima, Takeshi Fukushima Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells Journal of Health Science 2009 55:825-831 DOI: 10.1248/jhs.55.825

16638 Todorova R. Estimation of methods of protein delivery into mammalian cells--a comparative study by electroporation and bioporter assay Prikl Biokhim Mikrobiol 2009 45:493-6 PubMed ID: 19764622

18422 Homma K, Niino Y, Hotta K, Oka K. Ca(2+) influx through P2X receptors induces actin cytoskeleton reorganization by the formation of cofilin rods in neurites Mol Cell Neurosci 2008 37(2):261-70 PubMed ID: 17993279 DOI: 10.1016/j.mcn.2007.10.001

18449 Saito M, Shinohara Y, Sasaki H, Netsu Y, Yoshida M, Nakahata N. Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1//2 in AT1-R-transfected PC12 cells J Neuroendocrinol 2008 20(3):299-308 PubMed ID: 18208547 DOI: 10.1111/j.1365-2826.2008.01646.x

8723 Shinohara H, Wang F, Hossain SM. A convenient, high-throughput method for enzyme-luminescence detection of dopamine released from PC12 cells. Nat Protoc 2008 3:1639-44 PubMed ID: 18833200 DOI: 10.1038/nprot.2008.158

8759 Watanabe S, Wakasugi K. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry 2008 47:5266-70 PubMed ID: 18416560 DOI: 10.1021/bi800286m

18695 Masuda S, Yamamoto K, Hirabayashi T, Ishikawa Y, Ishii T, Kudo I, Murakami M. Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival Biochem J 2008 409(2):429-38 PubMed ID: 17868035 DOI: 10.1042/BJ20070844

18832 Fujikawa H, Kanno T, Nagata T, Nishizaki T. The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway Neurosci Lett 2008 448(2):208-11 PubMed ID: 18983890 DOI: 10.1016/j.neulet.2008.10.079

5328 Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T. Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa). Chem Pharm Bull (Tokyo) 2008 56(1):60-3 PubMed ID: 18175976 DOI: 10.1248/cpb.56.60

10359 Takashi K Saito, Munetoshi Seki, Hitoshi Tabata Self-organized ZnO Nanorod With Photooxidative Cell Membrane Perforation Enables Large-Scale Cell Manipulation Anal Bioanal Chem 2008 391(7):2513-9 PubMed ID: 18584155 DOI: 10.1007/s00216-008-2226-2

12792 Nusuetrong P, Pengsuparp T, Meksuriyen D, Tanitsu M, Kikuchi H, Mizugaki M, Shimazu K, Oshima Y, Nakahata N, Yoshida M. Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells Biol Pharm Bull 2008 31(6):1115-20 PubMed ID: 18520041 DOI: 10.1248/bpb.31.1115

12793 Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I. Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4) Biol Pharm Bull 2008 31(8):1580-4 PubMed ID: 18670092 DOI: 10.1248/bpb.31.1580

15110 Watanabe S, Wakasugi K. Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity Biochem Biophys Res Commun 2008 369(2):695-700 PubMed ID: 18302932 DOI: 10.1016/j.bbrc.2008.02.089

16071 Yoichiroh Hosokawa, Yuqiang Jiang, Isamu Oh, Noriko Takizawa, Takayuki Uwada, Kazunori Okano, Hiroshi Masuhara Femtosecond laser manipulation techniques for individual patterning of biological micro-object Optical Interactions with Tissue and Cells XIX 2008 DOI: 10.1117/12.762605

16640 Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T. A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells. J Neurochem 2008 10:1697-708 PubMed ID: 19014384 DOI: 10.1111/j.1471-4159.2008.05738.x

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8838 Hiroaki SHINOHARA and Feifei WANG Real-Time Detection of Dopamine Released from a Nerve Model Cell by an Enzyme-Catalyzed Luminescence Method and Its Application to Drug Assessment Anal Sci 2007 23:81-84 PubMed ID: 17213629 DOI: 10.2116/analsci.23.81

18619 Seyfried J, Wüllner U. Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway Biochem Biophys Res Commun 2007 359(3):759-64 PubMed ID: 17559804 DOI: 10.1016/j.bbrc.2007.05.176

6238 Ishii T, Ishimori H, Mori K, Uto T, Fukuda K, Urashima T, Nishimura M. Bovine lactoferrin stimulates anchorage-independent cell growth via membrane-associated chondroitin sulfate and heparan sulfate proteoglycans in PC12 cells. J Pharmacol Sci 2007 104(4):366-73 PubMed ID: 17675795 DOI: 10.1254/jphs.fp0070728

9489 Y Kamata, H Shiraga, A Tai, Y Kawamoto, E Gohda Induction of Neurite Outgrowth in PC12 Cells by the Medium-Chain Fatty Acid Octanoic Acid Neuroscience 2007 146(3):1073-81 PubMed ID: 17434686 DOI: 10.1016/j.neuroscience.2007.03.001

9490 T Fukuda, K Ishii, T Nanmoku, K Isobe, Y Kawakami, K Takekoshi 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside Stimulates Tyrosine Hydroxylase Activity and Catecholamine Secretion by Activation of AMP-activated Protein Kinase in PC12 Cells J Neuroendocrinol 2007 19(8):621-31 PubMed ID: 17620104 DOI: 10.1111/j.1365-2826.2007.01570.x

10361 Yayoi Murakami, Eriko Aizu-Yokota, Yoshiko Sonoda, Shigeo Ohta, Tadashi Kasahara Suppression of Endoplasmic Reticulum Stress-Induced Caspase Activation and Cell Death by the Overexpression of Bcl-xL or Bcl-2 J Biochem 2007 141(3):401-10 PubMed ID: 17301078 DOI: 10.1093/jb/mvm044

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8909 Hongo S, Watanabe T, Takahashi K, Miyazaki A. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. J. Cell. Biochem. 2006 98:185-93 PubMed ID: 16408304 DOI: 10.1002/jcb.20763

8918 Takayuki Hoshino, Akinori Ozasa, Reo Kometani, Takafumi Suzuki, Shinji Matsui, and Kunihiko Mabuchi Development of a regeneration-type neural interface: A microtube guide for axon growth of neuronal cells fabricated using focused-ion-beam chemical vapor deposition J Vacuum Science & Technology B 2006 24:2538-2543 DOI: 10.1116/1.2359730

8961 Ohnuma K, Hayashi Y, Furue M, Kaneko K, Asashima M. Serum-free culture conditions for serial subculture of undifferentiated PC12 cells. J. Neurosci. Methods 2006 151:250-61 PubMed ID: 16169086 DOI: 10.1016/j.jneumeth.2005.08.004

18831 Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T. The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site J Lipid Res 2006 47(6):1146-56 PubMed ID: 16520488 DOI: 10.1194/jlr.M500329-JLR200

5976 Watanabe K, Yaguchi T, Yang D, Kanno T, Nagai K, Yamamoto S, Fujikawa H, Yamamoto H, Nagata T, Tashiro C, Nishizaki T. Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins. Cryobiology 2006 53(3):330-5 PubMed ID: 17026979 DOI: 10.1016/j.cryobiol.2006.08.004

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17372 Takadera T, Yoshikawa R, Ohyashiki T. Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells Neurosci Lett 2006 408(2):124-8 PubMed ID: 16982147 DOI: 10.1016/j.neulet.2006.08.066

17373 Syuhei Shigaki, Tatsuhiko Sonoda, Takeyuki Nagashima, Osamu Okitsu, Yasuhiro Kita, Takuro Niidome, Yoshiki Katayama A new method for evaluation of intracellular protein kinase signals using mass spectrometry Science and Technology of Advanced Materials 2006 7:699-704 DOI: 10.1016/j.stam.2006.04.015

3186 Masuda, Seiko, Murakami, Makoto, Takanezawa, Yasukazu, Aoki, Junken, Arai, Hiroyuki, Ishikawa, Yukio, Ishii, Toshiharu, Arioka, Manabu, Kudo, Ichiro Neuronal expression and neuritogenic action of group X secreted phospholipase A2. J Biol Chem 2005 280:23203-14 PubMed ID: 15781456 DOI: 10.1074/jbc.M500985200

8944 Waki R, Gamo S, Bessho M, Hara M. Patterning cultured cells by visible light illumination with photosensitizers. J. Biosci. Bioeng. 2005 100:331-4 PubMed ID: 16243285 DOI: 10.1263/jbb.100.331

9048 Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines J Agric Food Chem 2005 53 (16), 6313-8 PubMed ID: 16076112 DOI: 10.1021/jf0506129

17367 Fukuda T, Takekoshi K, Nanmoku T, Ishii K, Isobe K, Kawakami Y. Inhibition of the RhoA/Rho kinase system attenuates catecholamine biosynthesis in PC 12 rat pheochromocytoma cells Biochim Biophys Acta 2005 1726(1):28-33 PubMed ID: 16219424 DOI: 10.1016/j.bbagen.2005.08.008

2295 Takata MK, Yamaguchi F, Nakanose K, Watanabe Y, Hatano N, Tsukamoto I, Nagata M, Izumori K, Tokuda M. Neuroprotective effect of D-psicose on 6-hydroxydopamine-induced apoptosis in rat pheochromocytoma (PC12) cells J Biosci Bioeng 2005 100(5):511-6 PubMed ID: 16384789 DOI: 10.1263/jbb.100.511

2717 Ishido M, Masuo Y Transcriptome of pituitary adenylate cyclase-activating polypeptide-differentiated PC12 cells Regul Pept 2004 15:15-21 PubMed ID: 15518888 DOI: 10.1016/j.regpep.2004.05.020

2716 Makino N, Sasaki K, Hashida K, Sakakura Y A metabolic model describing the H2O2 elimination by mammalian cells including H2O2 permeation through cytoplasmic and peroxisomal membranes: comparison with experimental data. Biochim Biophys Acta 2004 1673:149-59 PubMed ID: 15279886 DOI: 10.1016/j.bbagen.2004.04.011

3184 Shimokawa, Noriaki, Qiu, Chun-Hong, Seki, Takayuki, Dikic, Ivan, Koibuchi, Noriyuki Phosphorylation of JNK is involved in regulation of H(+)-induced c-Jun expression. Cell Signal 2004 16:723-9 PubMed ID: 15093613 DOI: 10.1016/j.cellsig.2003.11.005

17353 Muroi Y, Ishii T, Teramoto K, Hori M, Nishimura M. Calcineurin contributes to the enhancing effect of adenosine on nerve growth factor-induced neurite outgrowth via the decreased duration of p38 mitogen-activated protein kinase phosphorylation J Pharmacol Sci 2004 95(1):124-31 PubMed ID: 15153659 DOI: 10.1254/jphs.95.124

2647 Rajebhosale M, Greenwood S, Vidugiriene J, Jeromin A, Hilfiker S Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells J Biol Chem 2003 278:6075-6084 PubMed ID: 12471042 DOI: 10.1074/jbc.M204702200

3067 Hayashi, Hisaki, Ishisaki, Akira, Imamura, Toru Smad mediates BMP-2-induced upregulation of FGF-evoked PC12 cell differentiation. FEBS Lett 2003 536:30-4 PubMed ID: 12586333 DOI: 10.1016/s0014-5793(03)00005-x

9038 Masahiro Nagahama, Shinya Hayashi, Shinsuke Morimitsu, Jun Sakurai Biological Activities and Pore Formation of Clostridium Perfringens Beta Toxin in HL 60 Cells J Biol Chem 2003 278 (38), 36934-41 PubMed ID: 12851396 DOI: 10.1074/jbc.M306562200

9593 Xiaohua Zhou, Akihiro Tai, Itaru Yamamoto Enhancement of Neurite Outgrowth in PC12 Cells Stimulated With Cyclic AMP and NGF by 6-acylated Ascorbic Acid 2-O-alpha-glucosides (6-Acyl-AA-2G), Novel Lipophilic Ascorbate Derivatives Biol Pharm Bull 2003 26(3):341-6 PubMed ID: 12612444 DOI: 10.1248/bpb.26.341

17316 Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi Structure of a New Neuritogenic-Active Ganglioside from the Sea Cucumber Stichopus japonicus European Journal of Organic Chemistry 2003 1004-1008 DOI: 10.1002/ejoc.200390141

2715 Hashida, Kanae, Sakakura, Yuki, Makino, Nobuo Kinetic studies on the hydrogen peroxide elimination by cultured PC12 cells: rate limitation by glucose-6-phosphate dehydrogenase. Biochim Biophys Acta 2002 1572:85-90 PubMed ID: 12204336 DOI: 10.1016/s0304-4165(02)00282-9

3163 Takezawa, Takezawa, Takenouchi, Takato, Imai, Kei, Takahashi, Toru, Hashizume, Kazuyoshi Cell culture on thin tissue sections commonly prepared for histopathology. FASEB J 2002 16:1847-9 PubMed ID: 12223453 DOI: 10.1096/fj.02-0405fje

3007 Nagahama, Masami, Usui, Shihomi, Shinohara, Takashi, Yamaguchi, Tomohiro, Tani, Katsuko, Tagaya, Mitsuo Inactivation of Galpha(z) causes disassembly of the Golgi apparatus. J Cell Sci 2002 115:4483-93 PubMed ID: 12414994 DOI: 10.1242/jcs.00093

2641 Saito K. T, Muguruma H, Mabuchi K. Photodynamic assistance increases the efficiency of the process of microinjection in animal cells. Biotechnol Lett. 2002 24:309-314 DOI: 10.1023/A:1014072904009

6271 Tanigaki K, Sato T, Tanaka Y, Ochi T, Nishikawa A, Nagai K, Kawashima H, Ohkuma S. BE-18591 as a new H(+)/Cl(-) symport ionophore that inhibits immunoproliferation and gastritis. FEBS Lett 2002 524(1-3):37-42 PubMed ID: 12135738 DOI: 10.1016/s0014-5793(02)02996-4

9585 Yuka Suzuki-Mizushima, Eiichi Gohda, Takayuki Okamura, Kayoko Kanasaki, Itaru Yamamoto Enhancement of NGF- And Cholera Toxin-Induced Neurite Outgrowth by Butyrate in PC12 Cells Brain Res 2002 951(2):209-17 PubMed ID: 12270499 DOI: 10.1016/s0006-8993(02)03163-3

14334 Takekoshi K, Ishii K, Shibuya S, Kawakami Y, Isobe K, Nakai T. Stimulation of catecholamine biosynthesis via the protein kinase C pathway by endothelin-1 in PC12 rat pheochromocytoma cells Biochem Pharmacol 2002 63(5):977-84 PubMed ID: 11911850 DOI: 10.1016/s0006-2952(01)00862-0

17288 Morimoto A, Irie K, Murakami K, Ohigashi H, Shindo M, Nagao M, Shimizu T, Shirasawa T. Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23 Biochem Biophys Res Commun 2002 295(2):306-1 PubMed ID: 12150948 DOI: 10.1016/s0006-291x(02)00670-8

2306 Hiyoshi M, Ohkubo T, Tsuji K, Hagihara M, Nakasaki H, Mukai M, Makuuchi H, Yamamura M, Tsuda M. Hepatocyte proliferation factors from neonatal pig liver: purification and characterization Biofactors 2002 16(1-2):1-14 PubMed ID: 12515911 DOI: 10.1002/biof.5520160101

3068 Hayashi H, Ishisaki A, Suzuki M, Imamura T BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression. J Cell Sci 2001 114:1387-95 PubMed ID: 11257004 DOI: 10.1242/jcs.114.7.1387

2642 Saito, T K, Takahashi M, Muguruma H, Niki E, Mabuchi K Phototoxic process after rapid photosensitive membrane damage of 5,5"-bis(aminomethyl)-2,2':5',2"-terthiophene dihydrochloride. J Photochem Photobiol B 2001 61:114-21 PubMed ID: 11535410 DOI: 10.1016/s1011-1344(01)00167-1

10336 Kasai Y, Ohta T, Nakazato Y, Ito S. Release of dopamine and ATP from PC12 cells treated with dexamethasone, reserpine and bafilomycin A1. J. Vet. Med. Sci. 2001 63:367-72 PubMed ID: 11346169 DOI: 10.1292/jvms.63.367

5979 Matsumoto Y et al Improvement in the viability of cryopreserved cells by microencapsulation JSME International Journal Series C Mechanical Systems 2001 44:937-945 DOI: 10.1299/jsmec.44.937

9601 Y Nakayama, Y Aoki, H Niitsu Studies on the Mechanisms Responsible for the Formation of Focal Swellings on Neuronal Processes Using a Novel in Vitro Model of Axonal Injury Neurotrauma 2001 18(5):545-54. PubMed ID: 11393257 DOI: 10.1089/089771501300227341

9602 M Kimura, K I Hidari, T Suzuki, D Miyamoto, Y Suzuki Engagement of Endogenous Ganglioside GM1a Induces Tyrosine Phosphorylation Involved in Neuron-Like Differentiation of PC12 Cells Glycobiology 2001 11(4):335-43 PubMed ID: 11358882 DOI: 10.1093/glycob/11.4.335

14336 Yokomatsu T, Takechi H, Akiyama T, Shibuya S, Kominato T, Soeda S, Shimeno H. Synthesis and evaluation of a difluoromethylene analogue of sphingomyelin as an inhibitor of sphingomyelinase Bioorg Med Chem Lett 2001 11(10):1277-80 PubMed ID: 11392536 DOI: 10.1016/s0960-894x(01)00179-2

15657 Tsuji M, Inanami O, Kuwabara M. Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway J Biol Chem 2001 276(35):32779-85 PubMed ID: 11438521 DOI: 10.1074/jbc.M101403200

16910 Tanaka J, Koshimura K, Sohmiya M, Murakami Y, Kato Y. Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells Biochem Biophys Res Commun 2001 289(2):358-62 PubMed ID: 11716480 DOI: 10.1006/bbrc.2001.6002

3070 Sassa T, Gomi H, Sun W, Ikeda T, Thompson, R F, Itohara S Identification of variants and dual promoters of murine serine/threonine kinase KKIAMRE. J Neurochem 2000 74:1809-19 PubMed ID: 10800923 DOI: 10.1046/j.1471-4159.2000.0741809.x

3010 Mashima J, Nagahama M, Hatsuzawa K, Tani K, Horigome T, Yamamoto A, Tagaya M N-ethylmaleimide-sensitive factor is associated with the nuclear envelope. Biochem Biophys Res Commun 2000 274:559-64 PubMed ID: 10913377 DOI: 10.1006/bbrc.2000.3162

18649 Saida K, Uchide T, Usui A, Gao XD, Tomizuka N, Oka S, Masuda H. The endothelin-2/vasoactive intestinal contractor gene: expression and promoter activity in PC12 rat pheochromocytoma cells J Cardiovasc Pharmacol 2000 ;36(5 Suppl 1):S9-11 PubMed ID: 11078321 DOI: 10.1097/00005344-200036051-00005

5977 Sawada K, Konishi Y, Tominaga M, Watanabe Y, Hirano J, Inoue S, Kageyama R, Blum M, Tominaga A. Goosecoid suppresses cell growth and enhances neuronal differentiation of PC12 cells. J Cell Sci 2000 113 ( Pt 15):2705-13 PubMed ID: 10893186 DOI: 10.1242/jcs.113.15.2705

6158 Okui M, Ito F, Ogita K, Kuramoto N, Kudoh J, Shimizu N, Ide T. Expression of APG-2 protein, a member of the heat shock protein 110 family, in developing rat brain. Neurochem Int 2000 36(1):35-43 PubMed ID: 10566957 DOI: 10.1016/s0197-0186(99)00095-9

10888 K Takekoshi, K Ishii, K Isobe, F Nomura, T Nammoku, T Nakai Effects of Natriuretic Peptides (ANP, BNP, CNP) on Catecholamine Synthesis and TH mRNA Levels in PC12 Cells Life Sci 2000 66(22):PL303-11 PubMed ID: 10834306 DOI: 10.1016/s0024-3205(00)00549-x

10889 K Takekoshi, K Ishii, Y Kawakami, K Isobe, T Nakai kappa-Opioid Inhibits Catecholamine Biosynthesis in PC12 Rat Pheochromocytoma Cell FEBS Lett 2000 477(3):273-7 PubMed ID: 10908734 DOI: 10.1016/s0014-5793(00)01789-0

1511 Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Ishii K, Goto K, Nakai T. Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells Biochem Biophys Res Commun 2000 274(2):310-5 PubMed ID: 10913336 DOI: 10.1006/bbrc.2000.3137

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17273 Jianhua Qi, Makoto Ojika, Youji Sakagami Termitomycesphins A–D, Novel Neuritogenic Cerebrosides from the Edible Chinese Mushroom Termitomyces albuminosus Tetrahedron 2000 6:5835-5841 DOI: 10.1016/s0040-4020(00)00548-2

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6161 Okui M, Ide T, Morita K, Funakoshi E, Ito F, Ogita K, Yoneda Y, Kudoh J, Shimizu N. High-level expression of the Mnb/Dyrk1A gene in brain and heart during rat early development. Genomics 1999 62(2):165-71 PubMed ID: 10610708 DOI: 10.1006/geno.1999.5998

9618 Y Yamauchi, S Hongo, T Ohashi, S Shioda, C Zhou, Y Nakai, N Nishinaka, R Takahashi, F Takeda, M Takeda Molecular Cloning and Characterization of a Novel Developmentally Regulated Gene, Bdm1, Showing Predominant Expression in Postnatal Rat Brain Brain Res Mol Brain Res 1999 68(1-2):149-58 PubMed ID: 10320792 DOI: 10.1016/s0169-328x(99)00084-4

15567 Koshimura K, Murakami Y, Sohmiya M, Tanaka J, Kato Y. Effects of erythropoietin on neuronal activity J Neurochem 1999 72(6):2565-72 PubMed ID: 10349868 DOI: 10.1046/j.1471-4159.1999.0722565.x

16639 Owada K, Sanjyo N, Kobayashi T, Kamata T, Mizusawa H, Muramatsu H, Muramatsu T, Michikawa M. Midkine inhibits apoptosis via extracellular signal regulated kinase (ERK) activation in PC12 cells J Med Dent Sci 1999 46(1):45-51 PubMed ID: 12160213

17249 Miki Shibahara, Hiroko Isoda, Takehide Murata, Kazunari K. Yokoyama, Tadaatsu Nakahara Analysis of Glycosphingolipids on Differentiation-Induction of PC12 Pheochromocytoma Cells by Mannosylerythritol Lipid Animal Cell Technology: Basic & Applied Aspects 1999 329-333 DOI: 10.1007/0-306-46865-4_57

17271 Koshimura K, Tanaka J, Murakami Y, Kato Y. Enhancement of neuronal survival by 6R-tetrahydrobiopterin Neuroscience 1999 88(2):561-9 PubMed ID: 10197775 DOI: 10.1016/s0306-4522(98)00199-7

1913 Ichino N, Ishiguro H, Yamada K, Nishii K, Sawada H, Nagatsu T. Nicotine withdrawal up-regulates c-Fos transcription in pheochromocytoma cells Neurosci Res 1999 35(1):63-9 PubMed ID: 10555165 DOI: 10.1016/s0168-0102(99)00069-3

2389 Satoshi Kawatake, Masanori Inagaki, Tomofumi Miyamoto, Ryuichi Isobe, Ryuichi Higuchi Isolation and Structure of a GM3-Type Ganglioside Molecular Species European Journal of Organic Chemistry 1999 765-769 DOI: 10.1002/(sici)1099-0690(199904)1999:4<765::aid-ejoc765>3.0.co;2-7

2369 Takekoshi K, Nomura F, Isobe K, Motooka M, Nammoku T, Nakai T Identification and initial characterization of stathmin by the differential display method in nerve growth factor-treated PC12 cells. Eur J Endocrinol 1998 138:707-12 PubMed ID: 9678541 DOI: 10.1530/eje.0.1380707

3530 Sato N, Wang S, Li L, Okabe K, Hashimoto M, Yaginuma H, Mikoshiba K, Uchiyama Y, Uetsuki T, Yoshikawa K, Milligan CE, Oppenheim RW. A novel strategy for introducing exogenous bcl-2 into neuronal cells: the Cre/loxP system-mediated activation of bcl-2 for preventing programmed cell death using recombinant adenoviruses. Mol Cell Neurosci 1998 12(1-2):65-78 PubMed ID: 9770341 DOI: 10.1006/mcne.1998.0703

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17241 Watano T, Hara H, Sukamoto T. Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells Jpn J Pharmacol 1997 75(2):209-13 PubMed ID: 9414039 DOI: 10.1254/jjp.75.209

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2056 Shimokawa N, Miura M Detection of living cells that express AP1 using a fluorolabeled DNA probe. FEBS Lett 1996 388:16-20 PubMed ID: 8654580 DOI: 10.1016/0014-5793(96)00487-5

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2191 Kamata H, Tanaka C, Yagisawa H, Hirata H Nerve growth factor and forskolin prevent H2O2-induced apoptosis in PC12 cells by glutathione independent mechanism. Neurosci Lett 1996 212:179-82 PubMed ID: 8843102 DOI: 10.1016/0304-3940(96)12806-8

2190 Kamata H, Tanaka C, Yagisawa H, Matsuda S, Gotoh Y, Nishida E, Hirata H Suppression of nerve growth factor-induced neuronal differentiation of PC12 cells. N-acetylcysteine uncouples the signal transduction from ras to the mitogen-activated protein kinase cascade. J Biol Chem 1996 271:33018-25 PubMed ID: 8955147 DOI: 10.1074/jbc.271.51.33018

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