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Cell No. : Cell Name
RCB0009 : PC-12  update : 2024/06/21
CommentPheochromocytoma, differentiate by NGF stimulation. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Noda, Makoto
Originator L. Green & A. Tischler
Year of deposit 1986
Animal _rat < Mammals
Genus Rattus
Species norvegicus
Tissue pheochromocytoma
Classification cancer
History Mitubishi-Seimeiken-T.Amano
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0481
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS + 10% HS (GIBCO)
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Achoreplasma (-)
Animal PCR OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 343


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Reference
1726  Satoh M, Takeuchi M  Establishment of HPRT-deficient cell lines from mouse neuroblastoma Neuro-2a and rat pheochromocytoma PC12.  Res Commun Inst Ferment  1993  16:6-17  PubMed ID: 7763725  
1078  Levi A, Eldridge, J D, Paterson, B M  Molecular cloning of a gene sequence regulated by nerve growth factor.  Science  1985  229:393-5  PubMed ID: 3839317   DOI: 10.1126/science.3839317
1079  Biocca S, Cattaneo A, Calissano P  A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).  EMBO J  1983  2:643-8  PubMed ID: 6641712   DOI: 10.1002/j.1460-2075.1983.tb01478.x
1318  Greene, L A, Tischler, A S  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.  Proc Natl Acad Sci U S A  1976  73:2424-8  PubMed ID: 1065897   DOI: 10.1073/pnas.73.7.2424

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User's Publication
19537  Kazuo Nakazawa, Minako Matsuo, Yo Kikuchi, Yoshihiro Nakajima, Rika Numano  Melanopsin DNA aptamers can regulate input signals of mammalian circadian rhythms by altering the phase of the molecular clock  Frontiers in Neuroscience  2024  18    DOI: 10.3389/fnins.2024.1186677
21545  Suginoma H, Owada R, Katano-Toki A, Mori A, Fujioka J, Nakamura K.  Non-fibril form but not fibril form of human islet amyloid polypeptide 8-20 changes brain functions in mice.  PLoS One  2024  19(1):e0296750  PubMed ID: 38181010   DOI: 10.1371/journal.pone.0296750
21590  Hamano S, Noguchi T, Asai Y, Ito R, Komatsu R, Sato T, Inoue A, Maruyama T, Kudo TA, Hirata Y, Shindo S, Uchida Y, Hwang GW, Matsuzawa A.  Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos.  Cell Death Discov  2024  10(1):74  PubMed ID: 38346947   DOI: 10.1038/s41420-024-01838-2
21719  Chuma S, Kiyosue K, Akiyama T, Kinoshita M, Shimazaki Y, Uchiyama S, Sotoma S, Okabe K, Harada Y.  Implication of thermal signaling in neuronal differentiation revealed by manipulation and measurement of intracellular temperature.  Nat Commun  2024  15(1):3473  PubMed ID: 38724563   DOI: 10.1038/s41467-024-47542-8
21922  Ayaka Mori, Taichi Shiroishi, Jun Fujioka, Takashi Nakajima, Shinichi Mitsui, Hinaho Suginoma, Yohei Kakuta, Heishun Zen, Kazuhiro Nakamura  Infrared free electron laser-irradiated polyleucine does not exert aggregates-induced aversive effects on mouse brain  Brain Disorders  2024  14:100137    DOI: 10.1016/j.dscb.2024.100137
19538  Okami H, Kawaharada R, Yoshizaki H, Toriumi A, Tsutsumi S, Nakamura A.  Maternal n-7 Unsaturated Fatty Acids Protect the Fetal Brain from Neuronal Degeneration in an Intrauterine Hyperglycemic Animal Model  Nutrients  2023  15(15):3434  PubMed ID: 37571372   DOI: 10.3390/nu15153434
19564  Sasayama Y, Mamiya T, Qi J, Shibata T, Uchida K, Nabeshima T, Ojika M.  Neuritogenic steroid glycosides from crown-of-thorns starfish: Possible involvement of p38 mitogen-activated protein kinase and attenuation of cognitive impairment in senescence-acceler  Bioorg Med Chem  2023  78:117144  PubMed ID: 36577328   DOI: 10.1016/j.bmc.2022.117144
19648  Florence Hui Ping Tan, Andrew Chung Jie Ting, Nazalan Najimudin, Nobumoto Watanabe, Shaharum Shamsuddin, Azalina Zainuddin, Hiroyuki Osada, Ghows Azzam  3-[[(3S)-1,2,3,4-Tetrahydroisoquinoline-3-Carbonyl]Amino]Propanoic Acid (THICAPA) Is Protective Against Aβ42-Induced Toxicity In Vitro and in an Alzheimer’s Disease Drosophila  The Journals of Gerontology: Series A  2023  78:1944-1952    DOI: 10.1093/gerona/glad169
19657  Mochizuki R, Kobayashi A, Takayama H, Toida T, Ogra Y.  Simultaneous determination of intracellular reduced and oxidized glutathiones by the König reaction  Anal Methods  2023  15(28):3426-3431  PubMed ID: 37427721   DOI: 10.1039/d3ay00860f
19920  Tan FHP, Najimudin N, Watanabe N, Shamsuddin S, Azzam G.  p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model  Behav Brain Res  2023  452:114568  PubMed ID: 37414223   DOI: 10.1016/j.bbr.2023.114568
20995  Kiya R, Tang T, Tanaka Y, Hosokawa Y, Yalikun Y.  Microsecond cell triple-sorting enabled by multiple pulse irradiation of femtosecond laser.  Sci Rep  2023  13(1):405  PubMed ID: 36624119   DOI: 10.1038/s41598-022-27229-0
21075  Shibato J, Takenoya F, Yamashita M, Gupta R, Min CW, Kim ST, Kimura A, Takasaki I, Hori M, Shioda S, Rakwal R.  OMICS Analyses Unraveling Related Gene and Protein-Driven Molecular Mechanisms Underlying PACAP 38-Induced Neurite Outgrowth in PC12 Cells.  Int J Mol Sci  2023  24(4)  PubMed ID: 36835581   DOI: 10.3390/ijms24044169
21139  Ikemoto MJ, Aihara Y, Ishii N, Shigemori H.  3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.  Biol Pharm Bull  2023  46(4):599-607  PubMed ID: 37005304   DOI: 10.1248/bpb.b22-00727
21190  Yoshinaga N, Tateishi A, Kobayashi Y, Kubo T, Miyakawa H, Satoh K, Numata K.  Effect of Oligomers Derived from Biodegradable Polyesters on Eco- and Neurotoxicity.  Biomacromolecules  2023    PubMed ID: 37085155   DOI: 10.1021/acs.biomac.3c00160
21359  Nakamura M, Araki H, Tsurushima H, Oyane A.  Fabrication of water-dispersible and cell-stimulating calcium phosphate nanoparticles immobilizing basic fibroblast growth factor.  Colloids Surf B Biointerfaces  2023  230:113502  PubMed ID: 37574618   DOI: 10.1016/j.colsurfb.2023.113502
21393  Okumura H, Itoh SG, Zen H, Nakamura K.  Dissociation process of polyalanine aggregates by free electron laser irradiation.  PLoS One  2023  18(9):e0291093  PubMed ID: 37683014   DOI: 10.1371/journal.pone.0291093
21549  Tomita K, Oohara Y, Igarashi K, Kitanaka J, Kitanaka N, Tanaka KI, Roudkenar MH, Roushandeh AM, Sugimura M, Sato T.  Kamishoyosan and Kamikihito protect against decreased KCC2 expression induced by the P. gingivalis lipopolysaccharide treatment in PC-12 cells and improve behavioral abnormalities in male mice.  Heliyon  2023  9(12):e22784  PubMed ID: 38090003   DOI: 10.1016/j.heliyon.2023.e22784
21558  Mochizuki R, Ogra Y.  Determination of intracellular dopamine by liquid chromatography-fluorescence detection with post-column derivatization using the König reaction.  J Chromatogr B Analyt Technol Biomed Life Sci  2023  1232:123956  PubMed ID: 38128164   DOI: 10.1016/j.jchromb.2023.123956
17505  Owada R, Mitsui S, Nakamura K.  Exogenous polyserine and polyleucine are toxic to recipient cells  Sci Rep  2022  12(1):1685  PubMed ID: 35102230   DOI: 10.1038/s41598-022-05720-y
17513  Jamal M, Tsukamoto I, Maki T, Takei S, Konishi R, Kinoshita H.  COA-Cl Evokes Protective Responses Against H2O2-and 6-OHDA-Induced Toxic Injury in PC12 Cells  Neurotox Res  2022  40(6):2061-2071  PubMed ID: 36435924   DOI: 10.1007/s12640-022-00587-3
17535  Daichi Nagashima, Chisa Matsubara, Noa Mizukami, Akane Nakagawa, Megumi Furukawa, Masahiro Toho, Ryoken Aoki, Yasuo Watanabe and Nobuo Izumo  Effect of Coriander on H2O2-induced Oxidative Stress in PC12 Cells  Journal of Clinical and Medical Research  2022      DOI: 10.37191/mapsci-2582-4333-4(3)-115
17684  Luo YR, Kudo TA, Tominami K, Izumi S, Tanaka T, Hayashi Y, Noguchi T, Matsuzawa A, Nakai J, Hong G, Wang H.  SP600125 Enhances Temperature-Controlled Repeated Thermal Stimulation-Induced Neurite Outgrowth in PC12-P1F1 Cells  Int J Mol Sci  2022  23(24):15602  PubMed ID: 36555248   DOI: 10.3390/ijms232415602
17937  Morimoto E, Inagaki K, Komatsubara M, Terasaka T, Itoh Y, Fujisawa S, Sasaki E, Nishiyama Y, Hara T, Wada J.  Effects of Wnt-β-Catenin Signaling and Sclerostin on the Phenotypes of Rat Pheochromocytoma PC12 Cells  J Endocr Soc  2022  6(10):bvac121  PubMed ID: 36042979   DOI: 10.1210/jendso/bvac121
20405  Uchida M, Ushio S, Niimura T, Takechi K, Kawazoe H, Hidaka N, Tanaka A, Araki H, Zamami Y, Ishizawa K, Kitamura Y, Sendou T, Kawasaki H, Namba H, Shibata K, Tanaka M, Takatori S.  Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation.  Biol Pharm Bull  2022    PubMed ID: 34803077   DOI: 10.1248/bpb.b21-00852
20499  Tomita K, Yamanishi-Taira S, Igarashi K, Oogai Y, Kuwahara Y, Roudkenar MH, Roushandeh AM, Miyawaki S, Kurimasa A, Sato T.  Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells.  Peptides  2022  170734  PubMed ID: 34974081   DOI: 10.1016/j.peptides.2021.170734
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
20919  Owada R, Kakuta Y, Yoshida K, Mitsui S, Nakamura K.  Conditioned medium from BV2 microglial cells having polyleucine specifically alters startle response in mice.  Sci Rep  2022  12(1):18718  PubMed ID: 36333586   DOI: 10.1038/s41598-022-23571-5
20949  Chua P, Lim WK.  The strategic uses of collagen in adherent cell cultures.  Cell Biol Int  2022    PubMed ID: 36423248   DOI: 10.1002/cbin.11966
20958  Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M, Funato H.  Kinase signalling in excitatory neurons regulates sleep quantity and depth.  Nature  2022    PubMed ID: 36477539   DOI: 10.1038/s41586-022-05450-1
21026  Shinagawa T, Miyata S.  Three-Dimensional Cell Drawing Technique in Hydrogel Using Micro Injection System.  Micromachines (Basel)  2022  13(11)  PubMed ID: 36363885   DOI: 10.3390/mi13111866
21146  Koga T, Tai A.  Neurite Outgrowth-Promoting Compounds from Cockscomb Hydrolysate.  Nutrients  2022  14(7)  PubMed ID: 35406035   DOI: 10.3390/nu14071422
13538  Oguro A, Ishihara Y, Siswanto FM, Yamazaki T, Ishida A, Imaishi H, Imaoka S.  Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease  Biochim Biophys Acta Mol Cell Biol Lipids  2021  1866(2):158858  PubMed ID: 33279658   DOI: 10.1016/j.bbalip.2020.158858
20109  Chua P, Lim WK.  Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents.  Sci Rep  2021    PubMed ID: 33854099   DOI: 10.1038/s41598-021-87431-4
14195  Zhang T, Namoto M, Okano K, Akita E, Teranishi N, Tang T, Anggraini D, Hao Y, Tanaka Y, Inglis D, Yalikun Y, Li M, Hosokawa Y.  Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers  Sci Rep  2021  11(1):1652  PubMed ID: 33462348   DOI: 10.1038/s41598-021-81190-y
20171  Ando E, Higashi S, Mizokami A, Watanabe S, Hirata M, Takeuchi H.  Osteocalcin promotes proliferation, differentiation, and survival of PC12 cells.  Biochem Biophys Res Commun  2021  557:174-179  PubMed ID: 33865226   DOI: 10.1016/j.bbrc.2021.03.146
20333  Liang Y, Ueno M, Zha S, Okimura T, Jiang Z, Yamaguchi K, Hatakeyama T, Oda T.  Sulfated polysaccharide ascophyllan prevents amyloid fibril formation of human insulin and inhibits amyloid-induced hemolysis and cytotoxicity in PC12 cells.  Biosci Biotechnol Biochem  2021    PubMed ID: 34519773   DOI: 10.1093/bbb/zbab163
20463  Iizuka Y, Owada R, Kawasaki T, Hayashi F, Sonoyama M, Nakamura K.  Toxicity of internalized polyalanine to cells depends on aggregation.  Sci Rep  2021  11(1):23441  PubMed ID: 34873226   DOI: 10.1038/s41598-021-02889-6
16041  Tan FHP, Hadri NAB, Najimudin N, Watanabe N, Azzam G.  Ethyl caffeate ameliorated amyloid-beta42 protein-associated toxicity in PC12 cells and Drosophila melanogaster  Geriatr Gerontol Int   2021  21(12):1125-1130  PubMed ID: 34699118   DOI: 10.1111/ggi.14296
16234  Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, Azzam G.  Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease  J Ethnopharmacol  2021  8;279:114389  PubMed ID: 34217797   DOI: 10.1016/j.jep.2021.114389
16426  Li Xiao, Feng Liao, Yumei Fan, Nobuhiko Miwa  Ren Shen Yang Rong Tang and other traditional Chinese medicines exhibit antioxidant and anti-inflammatory capacities and suppress acetylcholinesterase activity in PC12 neuronal cells  Longhua Chinese Medicine  2021  4:13-13    DOI: 10.21037/lcm-21-12
20757  Shibato J, Takenoya F, Hirabayashi T, Kimura A, Yamashita M, Takasaki I, Rakwal R, Shioda S.  Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells.  Neural Plast  2021  2522454  PubMed ID: 34422037   DOI: 10.1155/2021/2522454
16796  Honda A, Hayasaka O, Mio K, Fujimura K, Kotani T, Komatsu M, Shiozaki K.  The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis  Biochimie  2021  185:105-116  PubMed ID: 33746065   DOI: 10.1016/j.biochi.2021.03.008
17754  Yamaguchi K, Mitsunaga T, Yamauchi K.  6-Paradol and its glucoside improve memory disorder in mice  Food Funct  2020  11(11):9892-9902  PubMed ID: 33094793   DOI: 10.1039/d0fo01975e
11760  Hsu YI, Yamaoka T.  Improved exposure of bioactive peptides to the outermost surface of the polylactic acid nanofiber scaffold.  J. Biomed. Mater. Res. Part B Appl. Biomater.  2020  108(4):1274-1280.  PubMed ID: 31429188   DOI: 10.1002/jbm.b.34475
11937  Usuki T, Yoshimoto Y, Sato M, Takenaka T, Takezawa R, Yoshida Y, Satake M, Suzuki N, Hashizume D, Dzyuba SV.  Bilobalide and PC12 cells: A structure activity relationship study.  Bioorg. Med. Chem.  2020    PubMed ID: 31848115   DOI: 10.1016/j.bmc.2019.115251
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870   DOI: 10.1016/j.heliyon.2020.e03301
13077  Xiao L, Liao F, Ide R, Horie T, Fan Y, Saiki C, Miwa N.  Enzyme-digested Colla Corii Asini (E'jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells.  Neural Regen Res  2020    PubMed ID: 32594048   DOI: 10.4103/1673-5374.285000
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13120  Tanaka N, Okuda M, Nishigaki T, Tsuchiya N, Kobayashi Y, Uemura T, Kumo S, Sugimoto H, Miyata S, Waku T.  Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins.  PLoS One  2020    PubMed ID: 32706773   DOI: 10.1371/journal.pone.0235979
13177  Nishimura A, Suwabe R, Ogihara Y, Yoshida S, Abe H, Osawa SI, Nakagawa A, Tominaga T, Nishizawa M.  Totally transparent hydrogel-based subdural electrode with patterned salt bridge.  Biomed Microdevices  2020    PubMed ID: 32827271   DOI: 10.1007/s10544-020-00517-0
13208  Owada R, Awata S, Suzue K, Kanetaka H, Kakuta Y, Nakamura K.  Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells.  Heliyon  2020    PubMed ID: 32954034   DOI: 10.1016/j.heliyon.2020.e04851
13366  Kobayashi Y, Oguro A, Yagi E, Mitani A, Kudoh SN, Imaoka S.  Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells.  J Toxicol Sci  2020    PubMed ID: 33268678   DOI: 10.2131/jts.45.783
13555  Koga T, Sakamoto T, Sakuradani E, Tai A.  Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds  Molecules  2020  25(20):4748  PubMed ID: 33081156   DOI: 10.3390/molecules25204748
13596  Rascher M, Wittstein K, Winter B, Rupcic Z, Wolf-Asseburg A, Stadler M, Köster RW.  Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction  Biomolecules  2020  10(10):1440  PubMed ID: 33066380   DOI: 10.3390/biom10101440
13642  Ikegami Y, Ijima H.  Development of heparin-conjugated nanofibers and a novel biological signal by immobilized growth factors for peripheral nerve regeneration  J Biosci Bioeng  2020  129(3):354-362  PubMed ID: 31601468   DOI: 10.1016/j.jbiosc.2019.09.004
13896  Madoka IMURA, Soichiro YAMADA, Koji YAMAMOTO, Yusuke MORITA, Eiji NAKAMACHI  Development of a three-dimensional cell culture system for the enhancement of nerve axonal extension by cyclic stretch stimulation  Journal of Biomechanical Science and Engineering  2020  15(4):20    DOI: 10.1299/jbse.20-00094
13942  Eiji NAKAMACHI, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA, Manabu OKITA  Development of a three-dimensional direct current electric field stimulation bioreactor to enhance the axonal outgrowth and control the axonal orientation  Journal of Biomechanical Science and Engineering  2020  15:19-00480    DOI: 10.1299/jbse.19-00480
14848  Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y.  Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study  Molecules  2020  25(18):420  PubMed ID: 32937854   DOI: 10.3390/molecules25184206
21797  Kudo TA, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Hong G, Nakai J.  Characterization of PC12 Cell Subclones with Different Sensitivities to Programmed Thermal Stimulation  Int J Mol Sci  2020  21(21):8356  PubMed ID: 33171774   DOI: 10.3390/ijms21218356
11262  Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H.  COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.  Brain Res.  2019    PubMed ID: 30366020   DOI: 10.1016/j.brainres.2018.10.026
11287  Nishizaki T.  Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death.  Mol. Neurobiol.  2019  56(7):4812-4819  PubMed ID: 30402707   DOI: 10.1007/s12035-018-1408-y
11420  Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.  Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.  Bioorg. Med. Chem.  2019    PubMed ID: 30733085   DOI: 10.1016/j.bmc.2019.01.038
11406  Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Okano Y, Masaki H.  3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress.  Exp. Dermatol.  2019    PubMed ID: 30698879   DOI: 10.1111/exd.13820
11488  Matsushima Y, Terada K, Kamei C, Sugimoto Y.  Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.  Eur. J. Pharmacol.  2019    PubMed ID: 30902656   DOI: 10.1016/j.ejphar.2019.03.032
4318  Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y.  Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells.  Biosci. Biotechnol. Biochem.  2019    PubMed ID: 30543144   DOI: 10.1080/09168451.2018.1553607
11658  Aruto Hori, Yuki Watabe, Masumi Yamada, Yuya Yajima, Rie Utoh, Minoru Seki  One-Step Formation of Microporous Hydrogel Sponges Encapsulating Living Cells by Utilizing Bicontinuous Dispersion of Aqueous Polymer Solutions  ACS Appl. Bio Mater.  2019    PubMed ID: 35030662   DOI: 10.1021/acsabm.9b00194
11812  Matsuzaki Y, Maruta R, Takaki K, Kotani E, Kato Y, Yoshimura R, Endo Y, Whitty C, Pernstich C, Gandhi R, Jones M, Mori H.  Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells.  Biomolecules  2019    PubMed ID: 31546991   DOI: 10.3390/biom9100510
9494  Keisuke Migita, Taichi Matsumoto, Kazuki Terada, Kazuhiko Ono, Shuji Hara  Effects of Geldanamycin on Neurite Outgrowth-Related Proteins and Kinases in Nerve Growth Factor-Differentiated Pheochromocytoma 12 Cells  J Pharmacol Sci  2019  140(3):255-262  PubMed ID: 31402210   DOI: 10.1016/j.jphs.2019.07.011
10509  Eiji NAKAMACHI, Ryota SAKIYAMA, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA  Enhancement of nerve axonal extension by an AC magnetic field stimulation bio-reactor using three-dimensional culture   Journal of Biomechanical Science and Engineering  2019  14(2)    DOI: 10.1299/jbse.19-00041
12153  Takanobu Haccho, Atsuru Kanno, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi  Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System  Plasma Medicine  2019      DOI: 10.1615/PlasmaMed.2020033059
12300  Florian Larramendy, Shotaro Yoshida, Daniela Maier, Zoltan Fekete, Shoji Takeuchi, Oliver Paul  3D arrays of microcages by two-photon lithography for spatial organization of living cells  Lab Chip   2019  19(5):875-884  PubMed ID: 30723853   DOI: 10.1039/c8lc01240g
12328  Ikeda T, Ichikawa K, Shigeto H, Ishida T, Hirota R, Funabashi H, Kuroda A.  Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish  Biosci Biotechnol Biochem  2019  83(12):2272-2275  PubMed ID: 31482750   DOI: 10.1080/09168451.2019.1659716
12361  Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.  Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy  J Neurochem  2019  148(3):373-385  PubMed ID: 30295925   DOI: 10.1111/jnc.14607
12550  Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M.  Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs  Medchemcomm  2019  0(7):1121-1125  PubMed ID: 31391884   DOI: 10.1039/c9md00011a
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10415  Mizukami-Murata S, Fujita K, Nakano T.  Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells.  Environ Sci Pollut Res Int  2018  25(17):16434-16445  PubMed ID: 28695493   DOI: 10.1007/s11356-017-9604-2
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10615  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.  Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.  Eur. J. Pharmacol.  2018  819:35-42  PubMed ID: 29154935   DOI: 10.1016/j.ejphar.2017.11.024
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10765  Sakagami H, Tsuji M, Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T, Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui T, Oizumi H, Oizumi T.  Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder.  In Vivo  2018  32:231-239  PubMed ID: 29475904   DOI: 10.21873/invivo.11229
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11215  Oguro A, Inoue T, Kudoh SN, Imaoka S.  14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.  Pharmacol Res Perspect  2018    PubMed ID: 30237892   DOI: 10.1002/prp2.428
11214  Koh I, Furusawa K, Haga H.  Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells.  Sci Rep  2018    PubMed ID: 30224813   DOI: 10.1038/s41598-018-32156-0
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454   DOI: 10.21873/invivo.11303
11255  Sano A, Shi H, Suzuki R, Shirataki Y, Sakagami H.  Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells.  In Vivo  2018    PubMed ID: 30348694   DOI: 10.21873/invivo.11392
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4315  Sun Z, Liu Y, Kong X, Wang R, Xu Y, Shang C, Huo J, Huang M, Zhao F, Bian K, Zhang S, Tu Y, Chen X.  Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2.  Cell. Physiol. Biochem.  2018    PubMed ID: 29794460   DOI: 10.1159/000490017
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4495  Masami Ishido  An Overview of Development of Quantitative Neurotoxicity Testing In vitro  Journal of Applied Life Sciences International  2018  19(2):1-9    DOI: 10.9734/JALSI/2018/45377
12549  Hsing‐An Lin, Bo Zhu, Yu‐Wei Wu, Jun Sekine, Aiko Nakao, Shyh‐Chyang Luo, Yoshiro Yamashita, Hsiao‐Hua Yu  Dynamic Poly(3,4‐ethylenedioxythiophene)s Integrate Low Impedance with Redox‐Switchable Biofunction  Advanced Functional Materials  2018  28    DOI: 10.1002/adfm.201703890
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14543  Mizuki Fujiwara, Kyoichi Ono, Takashi K. Saito  Photo-Oxidative Cell Membrane Perforation and Applied Cellular Level Neural Interface and Electrophysiological Recording in Animal Cells  2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS)  2018      DOI: 10.1109/mhs.2018.8886985
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9461  Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta  Methamphetamine Induces Shati/Nat8L Expression in the Mouse Nucleus Accumbens via CREB- And Dopamine D1 Receptor-Dependent Mechanism  PLoS One  2017  12(3):e0174196  PubMed ID: 28319198   DOI: 10.1371/journal.pone.0174196
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14483  Sasaki K, Othman MB, Demura M, Watanabe M, Isoda H.  Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii  Front Physiol  2017  8:900  PubMed ID: 29176952   DOI: 10.3389/fphys.2017.00900
14560  Arata Kaneko, , Yuuki Miyazaki, Tatsuya Goto  Transfer-Print of CNTs and its Application to Cell Scaffold  International Journal of Automation Technology  2017  11:941-946    DOI: 10.20965/ijat.2017.p0941
14566  Villareal MO, Ikeya A, Sasaki K, Arfa AB, Neffati M, Isoda H.  Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil  BMC Complement Altern Med  2017  17(1):549  PubMed ID: 29273038   DOI: 10.1186/s12906-017-2060-1
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9906  Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K.  Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.  Eur. J. Pharmacol.  2016  793:21-27  PubMed ID: 27815170   DOI: 10.1016/j.ejphar.2016.10.037
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10925    Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12  Planta Med Int Open  2016  3: e60–e63    DOI: 10.1055/s-0042-118778
10927  Naoto Ito ; Naoto Konno ; Takashi K. Saito  Sub-micrometer-scale wire-based intracellular metal microelectrode  IEEE Xplore  2016      DOI: 10.1109/MHS.2016.7824199
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14101  Iwori Takeda, Masato Kawanabe, Arata Kaneko  An investigation of cell adhesion and growth on micro/nano-scale structured surface—Self-assembled micro particles as a scaffold  Precision Engineering  2016  43:294-298    DOI: 10.1016/j.precisioneng.2015.08.009
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14167  Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Suganuma H, Ushida Y, Yamamoto M, Hashimoto K.  Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice  Sci Rep  2016  ;6:30659  PubMed ID: 27470577   DOI: 10.1038/srep30659
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7123  Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T.  Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy.  Anticancer Res.  2015  35:6431-7  PubMed ID: 26637853  
7160  Jin Y, Tsuchiya A, Kanno T, Nishizaki T.  Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.  Biochem. Biophys. Res. Commun.  2015  468:157-60  PubMed ID: 26522221   DOI: 10.1016/j.bbrc.2015.10.141
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7454  Takeda I, Kawanabe M, Kaneko A.  Autonomous patterning of cells on microstructured fine particles.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259   DOI: 10.1016/j.msec.2015.02.010
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6007  Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K.  Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease.  Biochim Biophys Acta  2015  853(12):3182-91  PubMed ID: 26319097   DOI: 10.1016/j.bbamcr.2015.08.013
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15043  Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M.  Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡)  Mar Drugs  2015  13(12):7250-74  PubMed ID: 26690179   DOI: 10.3390/md13127062
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15243  Kakinoki S, Seo JH, Inoue Y, Ishihara K, Yui N, Yamaoka T.  Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions  Acta Biomater  2015  13:42-51  PubMed ID: 25463493   DOI: 10.1016/j.actbio.2014.11.020
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19179  Ogasawara J, Ito T, Wakame K, Kitadate K, Sakurai T, Sato S, Ishibashi Y, Izawa T, Takahashi K, Ishida H, Takabatake I, Kizaki T, Ohno H.  ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells  Nat Prod Commun  2014  9(4):561-4  PubMed ID: 24868884  
19221  Koizumi K, Nakajima H.  Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway  Biomed Rep  2014  2(1):29-33  PubMed ID: 24649064   DOI: 10.3892/br.2013.203
15809  Takahashi K, Yokota M, Ohta T.  Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12  Exp Cell Res  2014  323(2):337-45  PubMed ID: 24630903   DOI: 10.1016/j.yexcr.2014.03.001
15821  Hiromichi NAKADATE, Yohei FUKUMURA, Yuma KANEKO, Akira KAKUTA, Hidenori FURUKAWA, Shigeru AOMURA  In vitro uniaxial stretch model for evaluating the effect of strain along axon on damage to neurons  Journal of Biomechanical Science and Engineering  2014  9:14-00136-14-00136    DOI: 10.1299/jbse.14-00136
15854  Matsui T, Yoshida Y, Yanagihara M, Suenaga H.  Hypothermia at 35 °C reduces the time-dependent microglial production of pro-inflammatory and anti-inflammatory factors that mediate neuronal cell death  Neurocrit Care  2014  20(2):301-10  PubMed ID: 24072458   DOI: 10.1007/s12028-013-9911-5
15855  Kakinoki S, Nakayama M, Moritan T, Yamaoka T.  Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid)  Front Chem  2014  2:52  PubMed ID: 25101261   DOI: 10.3389/fchem.2014.00052
15856  Kakinoki S , Yamaoka T .  Thermoresponsive elastin/laminin mimicking artificial protein for modifying PLLA scaffolds in nerve regeneration  J Mater Chem B  2014  2(31):5061-5067.  PubMed ID: 32261839   DOI: 10.1039/c4tb00305e
15857  Tsuchiya A, Nagaya H, Kanno T, Nishizaki T.  Oleic acid stimulates glucose uptake into adipocytes by enhancing insulin receptor signaling  J Pharmacol Sci  2014  126(4):337-43  PubMed ID: 25391857   DOI: 10.1254/jphs.14182FP
17156  H. Nakadate, S. Aomura, A. Kakuta  An in Vitro Stretch-Injury Model for Elongation-Controlled Neuronal Cells: Effect of Strains Along Neurite  IFMBE Proceedings  2014  756-759    DOI: 10.1007/978-3-319-02913-9_194
15765  Mouri K, Sako Y.  Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells  PLoS Comput Biol  2013  9(11):e1003320  PubMed ID: 24244131   DOI: 10.1371/journal.pcbi.1003320
15929  Shinohara H, Sakai Y, Mir TA.  Real-time monitoring of intracellular signal transduction in PC12 cells by two-dimensional surface plasmon resonance imager  Anal Biochem  2013  441(2):185-9  PubMed ID: 23891634   DOI: 10.1016/j.ab.2013.07.017
15957  Tatsuki SUGIHARA, Arata KANEKO  Self-Patterning of PC12 Cells on Micro-Structures of Protein-Modified Particles  Journal of Solid Mechanics and Materials Engineering  2013  7:142-154    DOI: 10.1299/jmmp.7.142
15959  Tomono S, Yasue Y, Miyoshi N, Ohshima H.  Cytotoxic effects of secosterols and their derivatives on several cultured cells  Biosci Biotechnol Biochem  2013  77(3):651-3  PubMed ID: 23470737   DOI: 10.1271/bbb.120758
15960  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner  Biochem J  2013  450(2):303-9  PubMed ID: 23256752   DOI: 10.1042/BJ20121348
15961  Nishimoto T, Kanno T, Shimizu T, Tanaka A, Nishizaki T.  Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002  Lipids  2013  48(1):23-8  PubMed ID: 23117296   DOI: 10.1007/s11745-012-3736-4
15962  Kouhei Horikawa, Takuya Yagyu, Yukio Yoshioka, Takeshi Fujiwara, Akihiko Kanamoto, Tetsuji Okamoto, Makoto Ojika  Petrosiols A–E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata  Tetrahedron  2013  69:101-106    DOI: 10.1016/j.tet.2012.10.063
15963  Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH.  SLITRK6 mutations cause myopia and deafness in humans and mice  J Clin Invest   2013  123(5):2094-102  PubMed ID: 23543054   DOI: 10.1172/JCI65853
7619  Hoshino T, Saito I, Kometani R, Samejima K, Matsui S, Suzuki T, Mabuchi K, Kato YX.  Improvement of neuronal cell adhesiveness on parylene with oxygen plasma treatment.  J. Biosci. Bioeng.  2012  113:395-8  PubMed ID: 22138385   DOI: 10.1016/j.jbiosc.2011.11.003
7641  Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX.  Neurite outgrowth of PC12 cells on diX (parylene) family materials.  Biotechnol Prog  2012  28:587-90  PubMed ID: 22052685   DOI: 10.1002/btpr.739
7700  Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.  Am. J. Physiol. Endocrinol. Metab.  2012  302:E615-25  PubMed ID: 21878661   DOI: 10.1152/ajpendo.00035.2011
6172  E L Omri A, Han J, Ben Abdrabbah M, Isoda H.  Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells.  Cytotechnology  2012  64(3):231-40  PubMed ID: 21861121   DOI: 10.1007/s10616-011-9352-y
9091  Punnee Nusuetrong, Masaki Saito, Haruhisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, Norimichi Nakahata  Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-Stranded Break in PC12 Cells  J Toxicol Sci  2012  37 (4), 803-12  PubMed ID: 22863859   DOI: 10.2131/jts.37.803
15744  Hiromichi NAKADATE, Hiroto UMAHASHI, Akira KAKUTA, Shigeru AOMURA  Progression to Cell Death Correlates with Neurite Swelling Induced by Stretch Injury  Journal of Biomechanical Science and Engineering  2012  7:406-415    DOI: 10.1299/jbse.7.406
15964  El Omri A, Han J, Kawada K, Ben Abdrabbah M, Isoda H.  Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways  Brain Res  2012  1437:16-25  PubMed ID: 22226506   DOI: 10.1016/j.brainres.2011.12.019
15965  Ishima T, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors  PLoS One  2012  7(5):e37989  PubMed ID: 22655093   DOI: 10.1371/journal.pone.0037989
15966  Masumi Yamada, Sari Sugaya, Yoji Naganuma, Minoru Seki  Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking  Soft Matter  2012  8:3122    DOI: 10.1039/c2sm07263g
15967  Iwori Takeda, Arata Kaneko, Yasuhiro Tanaka, Nobuyuki Moronuki  Selective Cell-Adhesion on Micro-Structured Fine Particles  Key Engineering Materials  2012  516:130-135    DOI: 10.4028/www.scientific.net/kem.516.130
15968  Aita Y, Ishii KA, Saito Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways  Am J Physiol Endocrinol Metab  2012  303(8):E1006-14  PubMed ID: 22912364   DOI: 10.1152/ajpendo.00156.2012
7590  Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T.  [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].  Rinsho Shinkeigaku  2011  51:890-1  PubMed ID: 22277406   DOI: 10.5692/clinicalneurol.51.890
7720  Toda T, Sunagawa T, Kanda T, Tagashira M, Shirasawa T, Shimizu T.  Apple Procyanidins Suppress Amyloid β-Protein Aggregation.  Biochem Res Int  2011  2011:784698  PubMed ID: 21826271   DOI: 10.1155/2011/784698
7737  Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A.  A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease.  Biomicrofluidics  2011  5:22214  PubMed ID: 21799720   DOI: 10.1063/1.3580756
7795  Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T.  Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G230-8  PubMed ID: 21636531   DOI: 10.1152/ajpgi.00436.2009
7803  Sohma Y, Wang H, Taniguchi A, Hirayama Y, Kakizawa T, Yamasaki M, Mukai H, Kiso Y.  Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.  Bioorg. Med. Chem.  2011  19:3787-92  PubMed ID: 21612934   DOI: 10.1016/j.bmc.2011.04.056
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973   DOI: 10.1016/j.febslet.2011.04.056
7889  Hashimoto K, Ishima T.  Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.  PLoS ONE  2011  6:e17431  PubMed ID: 21390260   DOI: 10.1371/journal.pone.0017431
7913  Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.  Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.  Bioorg. Med. Chem.  2011  19:1959-65  PubMed ID: 21345685   DOI: 10.1016/j.bmc.2011.01.059
7923  Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H.  Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform.  Chembiochem  2011  12:795-801  PubMed ID: 21341350   DOI: 10.1002/cbic.201000497
7932  Yabe T, Hosoda-Yabe R, Kanamaru Y, Kiso M.  A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin.  J. Biol. Chem.  2011  286:12397-406  PubMed ID: 21335559   DOI: 10.1074/jbc.M110.172155
7945  Shimizu T, Kanno T, Tanaka A, Nishizaki T.  α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.  Cell. Physiol. Biochem.  2011  27:149-58  PubMed ID: 21325832   DOI: 10.1159/000325217
7965  Onoue S, Kuriyama K, Uchida A, Mizumoto T, Yamada S.  Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.  Pharm. Res.  2011  28:1157-66  PubMed ID: 21287249   DOI: 10.1007/s11095-011-0379-8
8003  Itoh K, Ishima T, Kehler J, Hashimoto K.  Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.  Brain Res.  2011  1377:32-40  PubMed ID: 21211516   DOI: 10.1016/j.brainres.2010.12.075
8020  Shen J, Maruyama IN.  Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.  FEBS Lett.  2011  585:295-9  PubMed ID: 21187090   DOI: 10.1016/j.febslet.2010.12.031
8023  Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO.  The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.  J Ethnopharmacol  2011  134:313-22  PubMed ID: 21172413   DOI: 10.1016/j.jep.2010.12.016
8090  Maezawa Y, Okano K, Matsubara M, Masuhara H, Hosokawa Y.  Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force.  Biomed Microdevices  2011  13:117-22  PubMed ID: 20949320   DOI: 10.1007/s10544-010-9476-4
8097  Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A.  Effects of vibration on differentiation of cultured PC12 cells.  Biotechnol. Bioeng.  2011  108:592-9  PubMed ID: 20939009   DOI: 10.1002/bit.22961
8134  Takadera T, Koriyama Y, Kimura T, Kato S.  5-S-GAD attenuates Fe2+-induced lipid peroxidation and cell death in a neuronal cell model.  Neurotox Res  2011  20:26-31  PubMed ID: 20809179   DOI: 10.1007/s12640-010-9218-7
6146  Shyh‐Chyang Luo Bo Zhu Aiko Nakao Reiko Nakatomi Hsiao‐hua Yu  Functionalized Conducting Polymer Nano‐Networks from Controlled Oxidation Polymerization toward Cell Engineering  Advanced Engineering Materials  2011  13:B423-B427    DOI: 10.1002/adem.201080109
15714  Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K.  Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria  PLoS One  2011  e23684  PubMed ID: 21858208   DOI: 10.1371/journal.pone.0023684
16310  Kudo TA, Kanetaka H, Mizuno K, Ryu Y, Miyamoto Y, Nunome S, Zhang Y, Kano M, Shimizu Y, Hayashi H.  Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway  Genes Cells  2011  16(11):1121-32  PubMed ID: 21988724   DOI: 10.1111/j.1365-2443.2011.01556.x
8030  Hashimoto K, Ishima T.  A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.  PLoS ONE  2010  5:e15430  PubMed ID: 21151481   DOI: 10.1371/journal.pone.0015430
8053  Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K.  Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.  ACS Chem Neurosci  2010  1:747-56  PubMed ID: 22778811   DOI: 10.1021/cn100072e
8057  Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.  Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.  Biosci. Biotechnol. Biochem.  2010  74:2299-306  PubMed ID: 21071836   DOI: 10.1271/bbb.100524
8116  Minase T, Ishima T, Itoh K, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP? receptors.  Eur. J. Pharmacol.  2010  648:67-73  PubMed ID: 20854802   DOI: 10.1016/j.ejphar.2010.09.007
8124  Yaguchi T, Nagata T, Nishizaki T.  1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death.  Behav Brain Funct  2010  6:52  PubMed ID: 20831835   DOI: 10.1186/1744-9081-6-52
8157  Zeng KW, Ko H, Yang HO, Wang XM.  Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.  Neuropharmacology  2010  59:542-50  PubMed ID: 20708632   DOI: 10.1016/j.neuropharm.2010.07.020
8211  Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.  Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.  J. Biosci. Bioeng.  2010  110:572-6  PubMed ID: 20591731   DOI: 10.1016/j.jbiosc.2010.05.013
8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384   DOI: 10.1016/j.jbiosc.2010.02.001
8318  Goto E, Mukozawa M, Mori H, Hara M.  A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth.  J. Biosci. Bioeng.  2010  109:512-8  PubMed ID: 20347776   DOI: 10.1016/j.jbiosc.2009.11.002
8322  Zeng KW, Wang XM, Ko H, Yang HO.  Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells.  J Ethnopharmacol  2010  130:13-8  PubMed ID: 20347949   DOI: 10.1016/j.jep.2010.03.018
8333  Takadera T, Nakajima Y, Kanai Y.  Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:863-8  PubMed ID: 20300959   DOI: 10.1007/s10571-010-9514-z
8392  Oyane A, Tsurushima H, Ito A.  Highly efficient gene transfer system using a laminin-DNA-apatite composite layer.  J Gene Med  2010  12:194-206  PubMed ID: 20082421   DOI: 10.1002/jgm.1425
8405  Yasuyo Maezawa, Yoichiroh Hosokawa, Kazunori Okano, Mie Matsubara and Hiroshi Masuhara  In situ observation of cell-detachment process initiated by femtosecond laser-induced stress wave  Applied Physics A: Materials Science & Processing  2010  101:127-131    DOI: 10.1007/s00339-010-5771-4
8414  Aita Y, Kasahara T, Isobe K, Kawakami Y, Takekoshi K.  Effect of urotensin II on PC12 rat pheochromocytoma cells.  J. Neuroendocrinol.  2010  22:83-91  PubMed ID: 20025629   DOI: 10.1111/j.1365-2826.2009.01944.x
8427  Kakinoki S, Yamaoka T.  Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence.  Acta Biomater  2010  6:1925-30  PubMed ID: 19969110   DOI: 10.1016/j.actbio.2009.12.001
8511  Takadera T, Ohtsuka M, Aoki H.  Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:193-8  PubMed ID: 19688259   DOI: 10.1007/s10571-009-9442-y
19187  Tanaka A, Hamada N, Fujita Y, Itoh T, Nozawa Y, Iinuma M, Ito M.  A novel kavalactone derivative protects against H2O2-induced PC12 cell death via Nrf2/ARE activation  Bioorg Med Chem  2010  18(9):3133-9  PubMed ID: 20371185   DOI: 10.1016/j.bmc.2010.03.034
15563  Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN.  Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics  Cell  2010  141(5):884-9  PubMed ID: 20493519   DOI: 10.1016/j.cell.2010.03.054
15694  Yuelin ZHANG, Shigeru AOMURA, Kiyoto FURUSE, Akira KAKUTA, Satoshi FUJIWARA, Ayako NASU  Study on Impact Resistance of PC12 Cells  Journal of Biomechanical Science and Engineering  2010  5:119-128    DOI: 10.1299/jbse.5.119
8518  Kato YX, Saito I, Takano H, Mabuchi K, Hoshino T.  Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family.  Neurosci. Lett.  2009  464:26-8  PubMed ID: 19664682   DOI: 10.1016/j.neulet.2009.08.007
8544  Ohnuma K, Toyota T, Ariizumi T, Sugawara T, Asashima M.  Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber.  J. Biosci. Bioeng.  2009  108:76-83  PubMed ID: 19577197   DOI: 10.1016/j.jbiosc.2009.02.020
8556  Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M.  Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway.  J Neural Transm (Vienna)  2009  116:841-52  PubMed ID: 19533291   DOI: 10.1007/s00702-009-0250-9
8647  Ishii T, Uto T, Mori K, Fujikawa R.  Integrin-linked kinase is involved in lactoferrin-induced anchorage-independent cell growth and survival in PC12 cells.  Life Sci.  2009  84:530-6  PubMed ID: 19230838   DOI: 10.1016/j.lfs.2009.01.025
15697  Atsushi Kira, Kazunori Okano, Yoichiroh Hosokawa, Akira Naito, Koh Fuwa, Jyunpei Yuyama, Hiroshi Masuhara  Micropatterning of perfluoroalkyl self-assembled monolayers for arraying proteins and cells on chips  Applied Surface Science  2009  255:7647-7651    DOI: 10.1016/j.apsusc.2009.04.044
15698  Sumiko Iwasa, Akina Enomoto, Satomi Onoue, Minako Nakai, Takehiko Yajima, Takeshi Fukushima  Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells  Journal of Health Science  2009  55:825-831    DOI: 10.1248/jhs.55.825
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18449  Saito M, Shinohara Y, Sasaki H, Netsu Y, Yoshida M, Nakahata N.  Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1//2 in AT1-R-transfected PC12 cells  J Neuroendocrinol  2008  20(3):299-308  PubMed ID: 18208547   DOI: 10.1111/j.1365-2826.2008.01646.x
8723  Shinohara H, Wang F, Hossain SM.  A convenient, high-throughput method for enzyme-luminescence detection of dopamine released from PC12 cells.  Nat Protoc  2008  3:1639-44  PubMed ID: 18833200   DOI: 10.1038/nprot.2008.158
8759  Watanabe S, Wakasugi K.  Zebrafish neuroglobin is a cell-membrane-penetrating globin.  Biochemistry  2008  47:5266-70  PubMed ID: 18416560   DOI: 10.1021/bi800286m
18695  Masuda S, Yamamoto K, Hirabayashi T, Ishikawa Y, Ishii T, Kudo I, Murakami M.  Human group III secreted phospholipase A2 promotes neuronal outgrowth and survival  Biochem J  2008  409(2):429-38  PubMed ID: 17868035   DOI: 10.1042/BJ20070844
18832  Fujikawa H, Kanno T, Nagata T, Nishizaki T.  The phosphodiesterase III inhibitor olprinone inhibits hippocampal glutamate release via a cGMP/PKG pathway  Neurosci Lett  2008  448(2):208-11  PubMed ID: 18983890   DOI: 10.1016/j.neulet.2008.10.079
5328  Kuroyanagi M, Ikeda R, Gao HY, Muto N, Otaki K, Sano T, Kawahara N, Nakane T.  Neurite outgrowth-promoting active constituents of the Japanese cypress (Chamaecyparis obtusa).  Chem Pharm Bull (Tokyo)  2008  56(1):60-3  PubMed ID: 18175976   DOI: 10.1248/cpb.56.60
10359  Takashi K Saito, Munetoshi Seki, Hitoshi Tabata  Self-organized ZnO Nanorod With Photooxidative Cell Membrane Perforation Enables Large-Scale Cell Manipulation  Anal Bioanal Chem  2008  391(7):2513-9  PubMed ID: 18584155   DOI: 10.1007/s00216-008-2226-2
12792  Nusuetrong P, Pengsuparp T, Meksuriyen D, Tanitsu M, Kikuchi H, Mizugaki M, Shimazu K, Oshima Y, Nakahata N, Yoshida M.  Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells  Biol Pharm Bull   2008  31(6):1115-20  PubMed ID: 18520041   DOI: 10.1248/bpb.31.1115
12793  Nakamura T, Yoshida K, Yabuuchi H, Maeda T, Tamai I.  Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4)  Biol Pharm Bull  2008  31(8):1580-4  PubMed ID: 18670092   DOI: 10.1248/bpb.31.1580
16071  Yoichiroh Hosokawa, Yuqiang Jiang, Isamu Oh, Noriko Takizawa, Takayuki Uwada, Kazunori Okano, Hiroshi Masuhara  Femtosecond laser manipulation techniques for individual patterning of biological micro-object  Optical Interactions with Tissue and Cells XIX  2008      DOI: 10.1117/12.762605
16640  Niwa M, Nitta A, Cen X, Kitaichi K, Ozaki N, Yamada K, Nabeshima T.  A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells.  J Neurochem  2008  10:1697-708  PubMed ID: 19014384   DOI: 10.1111/j.1471-4159.2008.05738.x
17117  Noriko Takizawa, Kazunori Okano, Takayuki Uwada, Yoichiroh Hosokawa, Hiroshi Masuhara  Viability evaluation of culture cells patterned by femtosecond laser-induced impulsive force  Optical Interactions with Tissue and Cells XIX  2008      DOI: 10.1117/12.762584
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18619  Seyfried J, Wüllner U.  Inhibition of thioredoxin reductase induces apoptosis in neuronal cell lines: role of glutathione and the MKK4/JNK pathway  Biochem Biophys Res Commun  2007  359(3):759-64  PubMed ID: 17559804   DOI: 10.1016/j.bbrc.2007.05.176
6238  Ishii T, Ishimori H, Mori K, Uto T, Fukuda K, Urashima T, Nishimura M.  Bovine lactoferrin stimulates anchorage-independent cell growth via membrane-associated chondroitin sulfate and heparan sulfate proteoglycans in PC12 cells.  J Pharmacol Sci  2007  104(4):366-73  PubMed ID: 17675795   DOI: 10.1254/jphs.fp0070728
9489  Y Kamata, H Shiraga, A Tai, Y Kawamoto, E Gohda  Induction of Neurite Outgrowth in PC12 Cells by the Medium-Chain Fatty Acid Octanoic Acid  Neuroscience  2007  146(3):1073-81  PubMed ID: 17434686   DOI: 10.1016/j.neuroscience.2007.03.001
9490  T Fukuda, K Ishii, T Nanmoku, K Isobe, Y Kawakami, K Takekoshi  5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside Stimulates Tyrosine Hydroxylase Activity and Catecholamine Secretion by Activation of AMP-activated Protein Kinase in PC12 Cells  J Neuroendocrinol  2007  19(8):621-31  PubMed ID: 17620104   DOI: 10.1111/j.1365-2826.2007.01570.x
10361  Yayoi Murakami, Eriko Aizu-Yokota, Yoshiko Sonoda, Shigeo Ohta, Tadashi Kasahara  Suppression of Endoplasmic Reticulum Stress-Induced Caspase Activation and Cell Death by the Overexpression of Bcl-xL or Bcl-2  J Biochem  2007  141(3):401-10  PubMed ID: 17301078   DOI: 10.1093/jb/mvm044
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18831  Kanno T, Yamamoto H, Yaguchi T, Hi R, Mukasa T, Fujikawa H, Nagata T, Yamamoto S, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA selectively activates PKC-epsilon, possibly binding to the phosphatidylserine binding site  J Lipid Res  2006  47(6):1146-56  PubMed ID: 16520488   DOI: 10.1194/jlr.M500329-JLR200
5976  Watanabe K, Yaguchi T, Yang D, Kanno T, Nagai K, Yamamoto S, Fujikawa H, Yamamoto H, Nagata T, Tashiro C, Nishizaki T.  Beneficial effect of intracellular free high-mannose oligosaccharides on cryopreservation of mammalian cells and proteins.  Cryobiology  2006  53(3):330-5  PubMed ID: 17026979   DOI: 10.1016/j.cryobiol.2006.08.004
6444  Yamazaki M, Chiba K, Mohri T.  Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells.  Neurosci Lett  2006  393(2-3):222-5  PubMed ID: 16239071   DOI: 10.1016/j.neulet.2005.09.068
17372  Takadera T, Yoshikawa R, Ohyashiki T.  Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells  Neurosci Lett  2006  408(2):124-8  PubMed ID: 16982147   DOI: 10.1016/j.neulet.2006.08.066
17373  Syuhei Shigaki, Tatsuhiko Sonoda, Takeyuki Nagashima, Osamu Okitsu, Yasuhiro Kita, Takuro Niidome, Yoshiki Katayama  A new method for evaluation of intracellular protein kinase signals using mass spectrometry  Science and Technology of Advanced Materials  2006  7:699-704    DOI: 10.1016/j.stam.2006.04.015
3186  Masuda, Seiko, Murakami, Makoto, Takanezawa, Yasukazu, Aoki, Junken, Arai, Hiroyuki, Ishikawa, Yukio, Ishii, Toshiharu, Arioka, Manabu, Kudo, Ichiro  Neuronal expression and neuritogenic action of group X secreted phospholipase A2.  J Biol Chem  2005  280:23203-14  PubMed ID: 15781456   DOI: 10.1074/jbc.M500985200
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9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
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17316  Masafumi Kaneko, Fumiaki Kisa, Koji Yamada, Tomofumi Miyamoto, Ryuichi Higuchi  Structure of a New Neuritogenic-Active Ganglioside from the Sea Cucumber Stichopus japonicus  European Journal of Organic Chemistry  2003  1004-1008    DOI: 10.1002/ejoc.200390141
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