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Cell No. : Cell Name
RCB0009 : PC-12  update : 2022/07/28
CommentPheochromocytoma, differentiate by NGF stimulation. Application consideration
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Noda, Makoto
Originator L. Green & A. Tischler
Year of deposit 1986
Animal rat < Mammals
Genus Rattus
Species norvegicus
Tissue pheochromocytoma
Classification cancer
History Mitubishi-Seimeiken-T.Amano
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0481
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS + 10% HS (GIBCO)
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
deposit info
lot info
Reference information Reference 4
User's Publication 271

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1726  Satoh M, Takeuchi M  Establishment of HPRT-deficient cell lines from mouse neuroblastoma Neuro-2a and rat pheochromocytoma PC12.  Res Commun Inst Ferment  1993  16:6-17  PubMed ID: 7763725
1078  Levi A, Eldridge, J D, Paterson, B M  Molecular cloning of a gene sequence regulated by nerve growth factor.  Science  1985  229:393-5  PubMed ID: 3839317
1079  Biocca S, Cattaneo A, Calissano P  A macromolecular structure favouring microtubule assembly in NGF-differentiated pheochromocytoma cells (PC12).  EMBO J  1983  2:643-8  PubMed ID: 6641712
1318  Greene, L A, Tischler, A S  Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.  Proc Natl Acad Sci U S A  1976  73:2424-8  PubMed ID: 1065897

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User's Publication
20405  Uchida M, Ushio S, Niimura T, Takechi K, Kawazoe H, Hidaka N, Tanaka A, Araki H, Zamami Y, Ishizawa K, Kitamura Y, Sendou T, Kawasaki H, Namba H, Shibata K, Tanaka M, Takatori S.  Renin-angiotensin-aldosterone system inhibitors prevent the onset of oxaliplatin-induced peripheral neuropathy: A retrospective multicenter study and in vitro evaluation.  Biol Pharm Bull  2022    PubMed ID: 34803077
20499  Tomita K, Yamanishi-Taira S, Igarashi K, Oogai Y, Kuwahara Y, Roudkenar MH, Roushandeh AM, Miyawaki S, Kurimasa A, Sato T.  Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells.  Peptides  2022  170734  PubMed ID: 34974081
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748
13538  Oguro A, Ishihara Y, Siswanto FM, Yamazaki T, Ishida A, Imaishi H, Imaoka S.  Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease  Biochim Biophys Acta Mol Cell Biol Lipids  2021  1866(2):158858  PubMed ID: 33279658
20109  Chua P, Lim WK.  Optimisation of a PC12 cell-based in vitro stroke model for screening neuroprotective agents.  Sci Rep  2021    PubMed ID: 33854099
14195  Zhang T, Namoto M, Okano K, Akita E, Teranishi N, Tang T, Anggraini D, Hao Y, Tanaka Y, Inglis D, Yalikun Y, Li M, Hosokawa Y.  Hydrodynamic particle focusing enhanced by femtosecond laser deep grooving at low Reynolds numbers  Sci Rep  2021  11(1):1652  PubMed ID: 33462348
20171  Ando E, Higashi S, Mizokami A, Watanabe S, Hirata M, Takeuchi H.  Osteocalcin promotes proliferation, differentiation, and survival of PC12 cells.  Biochem Biophys Res Commun  2021  557:174-179  PubMed ID: 33865226
20333  Liang Y, Ueno M, Zha S, Okimura T, Jiang Z, Yamaguchi K, Hatakeyama T, Oda T.  Sulfated polysaccharide ascophyllan prevents amyloid fibril formation of human insulin and inhibits amyloid-induced hemolysis and cytotoxicity in PC12 cells.  Biosci Biotechnol Biochem  2021    PubMed ID: 34519773
20463  Iizuka Y, Owada R, Kawasaki T, Hayashi F, Sonoyama M, Nakamura K.  Toxicity of internalized polyalanine to cells depends on aggregation.  Sci Rep  2021  11(1):23441  PubMed ID: 34873226
16041  Tan FHP, Hadri NAB, Najimudin N, Watanabe N, Azzam G.  Ethyl caffeate ameliorated amyloid-beta42 protein-associated toxicity in PC12 cells and Drosophila melanogaster  Geriatr Gerontol Int   2021  21(12):1125-1130  PubMed ID: 34699118
16234  Tan FHP, Ting ACJ, Leow BG, Najimudin N, Watanabe N, Azzam G.  Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease  J Ethnopharmacol  2021  8;279:114389  PubMed ID: 34217797
16426  Li Xiao, Feng Liao, Yumei Fan, Nobuhiko Miwa  Ren Shen Yang Rong Tang and other traditional Chinese medicines exhibit antioxidant and anti-inflammatory capacities and suppress acetylcholinesterase activity in PC12 neuronal cells  Longhua Chinese Medicine  2021  4:13-13 
20757  Shibato J, Takenoya F, Hirabayashi T, Kimura A, Yamashita M, Takasaki I, Rakwal R, Shioda S.  Molecular Mechanism for PACAP 38-Induced Neurite Outgrowth in PC12 Cells.  Neural Plast  2021  2522454  PubMed ID: 34422037
16796  Honda A, Hayasaka O, Mio K, Fujimura K, Kotani T, Komatsu M, Shiozaki K.  The involvement of Nile tilapia (Oreochromis niloticus) Neu4 sialidase in neural differentiation during early ontogenesis  Biochimie  2021  185:105-116  PubMed ID: 33746065
11760  Hsu YI, Yamaoka T.  Improved exposure of bioactive peptides to the outermost surface of the polylactic acid nanofiber scaffold.  J. Biomed. Mater. Res. Part B Appl. Biomater.  2020  108(4):1274-1280.  PubMed ID: 31429188
11937  Usuki T, Yoshimoto Y, Sato M, Takenaka T, Takezawa R, Yoshida Y, Satake M, Suzuki N, Hashizume D, Dzyuba SV.  Bilobalide and PC12 cells: A structure activity relationship study.  Bioorg. Med. Chem.  2020    PubMed ID: 31848115
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870
13077  Xiao L, Liao F, Ide R, Horie T, Fan Y, Saiki C, Miwa N.  Enzyme-digested Colla Corii Asini (E'jiao) prevents hydrogen peroxide-induced cell death and accelerates amyloid beta clearance in neuronal-like PC12 cells.  Neural Regen Res  2020    PubMed ID: 32594048
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607
13120  Tanaka N, Okuda M, Nishigaki T, Tsuchiya N, Kobayashi Y, Uemura T, Kumo S, Sugimoto H, Miyata S, Waku T.  Development of a brain-permeable peptide nanofiber that prevents aggregation of Alzheimer pathogenic proteins.  PLoS One  2020    PubMed ID: 32706773
13177  Nishimura A, Suwabe R, Ogihara Y, Yoshida S, Abe H, Osawa SI, Nakagawa A, Tominaga T, Nishizawa M.  Totally transparent hydrogel-based subdural electrode with patterned salt bridge.  Biomed Microdevices  2020    PubMed ID: 32827271
13208  Owada R, Awata S, Suzue K, Kanetaka H, Kakuta Y, Nakamura K.  Polyglutamine-containing microglia leads to disturbed differentiation and neurite retraction of neuron-like cells.  Heliyon  2020    PubMed ID: 32954034
13366  Kobayashi Y, Oguro A, Yagi E, Mitani A, Kudoh SN, Imaoka S.  Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells.  J Toxicol Sci  2020    PubMed ID: 33268678
13555  Koga T, Sakamoto T, Sakuradani E, Tai A.  Neurite Outgrowth-Promoting Activity of Compounds in PC12 Cells from Sunflower Seeds  Molecules  2020  25(20):4748  PubMed ID: 33081156
13596  Rascher M, Wittstein K, Winter B, Rupcic Z, Wolf-Asseburg A, Stadler M, Köster RW.  Erinacine C Activates Transcription from a Consensus ETS DNA Binding Site in Astrocytic Cells in Addition to NGF Induction  Biomolecules  2020  10(10):1440  PubMed ID: 33066380
13642  Ikegami Y, Ijima H.  Development of heparin-conjugated nanofibers and a novel biological signal by immobilized growth factors for peripheral nerve regeneration  J Biosci Bioeng  2020  129(3):354-362  PubMed ID: 31601468
13896  Madoka IMURA, Soichiro YAMADA, Koji YAMAMOTO, Yusuke MORITA, Eiji NAKAMACHI  Development of a three-dimensional cell culture system for the enhancement of nerve axonal extension by cyclic stretch stimulation  Journal of Biomechanical Science and Engineering  2020  15(4):20 
13942  Eiji NAKAMACHI, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA, Manabu OKITA  Development of a three-dimensional direct current electric field stimulation bioreactor to enhance the axonal outgrowth and control the axonal orientation  Journal of Biomechanical Science and Engineering  2020  15:19-00480 
13945  Florence Hui Ping Tan et al  Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer’s disease  bioRxiv  2020  2020-5-14 
14848  Terada K, Murata A, Toki E, Goto S, Yamakawa H, Setoguchi S, Watase D, Koga M, Takata J, Matsunaga K, Karube Y.  Atypical Antipsychotic Drug Ziprasidone Protects against Rotenone-Induced Neurotoxicity: An In Vitro Study  Molecules  2020  25(18):420  PubMed ID: 32937854
11262  Jamal M, Tsukamoto I, Takata M, Ito A, Tanaka N, Miki T, Takakura A, Ameno K, Kubota Y, Konishi R, Kinoshita H.  COA-Cl induces dopamine release and tyrosine hydroxylase phosphorylation: In vivo reverse microdialysis and in vitro analysis.  Brain Res.  2019    PubMed ID: 30366020
11287  Nishizaki T.  Fe3+ Facilitates Endocytic Internalization of Extracellular Aβ1-42 and Enhances Aβ1-42-Induced Caspase-3/Caspase-4 Activation and Neuronal Cell Death.  Mol. Neurobiol.  2019  56(7):4812-4819  PubMed ID: 30402707
11420  Yamamoto M, Shinoda K, Sasaki D, Kanai M, Sohma Y.  Design and properties of [Met35(O)]Aβ42-lactam(Asp23/Lys28) possessing a lactam tether as a salt-bridge surrogate.  Bioorg. Med. Chem.  2019    PubMed ID: 30733085
11406  Katsuyama Y, Taira N, Tsuboi T, Yoshioka M, Okano Y, Masaki H.  3-O-Laurylglyceryl ascorbate improves the development of sensitive skin through the reduction of oxidative stress.  Exp. Dermatol.  2019    PubMed ID: 30698879
11488  Matsushima Y, Terada K, Kamei C, Sugimoto Y.  Sertraline inhibits nerve growth factor-induced neurite outgrowth in PC12 cells via a mechanism involving the sigma-1 receptor.  Eur. J. Pharmacol.  2019    PubMed ID: 30902656
4318  Matsushima Y, Terada K, Takata J, Karube Y, Kamei C, Sugimoto Y.  Effects of fluvoxamine on nerve growth factor-induced neurite outgrowth inhibition by dexamethasone in PC12 cells.  Biosci. Biotechnol. Biochem.  2019    PubMed ID: 30543144
11812  Matsuzaki Y, Maruta R, Takaki K, Kotani E, Kato Y, Yoshimura R, Endo Y, Whitty C, Pernstich C, Gandhi R, Jones M, Mori H.  Sustained Neurotrophin Release from Protein Nanoparticles Mediated by Matrix Metalloproteinases Induces the Alignment and Differentiation of Nerve Cells.  Biomolecules  2019    PubMed ID: 31546991
9494  Keisuke Migita, Taichi Matsumoto, Kazuki Terada, Kazuhiko Ono, Shuji Hara  Effects of Geldanamycin on Neurite Outgrowth-Related Proteins and Kinases in Nerve Growth Factor-Differentiated Pheochromocytoma 12 Cells  J Pharmacol Sci  2019  140(3):255-262  PubMed ID: 31402210
10509  Eiji NAKAMACHI, Ryota SAKIYAMA, Shohei TANAKA, Koji YAMAMOTO, Yusuke MORITA  Enhancement of nerve axonal extension by an AC magnetic field stimulation bio-reactor using three-dimensional culture   Journal of Biomechanical Science and Engineering  2019  14(2) 
12153  Takanobu Haccho, Atsuru Kanno, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi  Enhancement of PC12 Neurite Extension via Plasma-Activated Medium by Nonthermal Atmospheric-Pressure Plasma-Bubbling System  Plasma Medicine  2019   
12300  Florian Larramendy, Shotaro Yoshida, Daniela Maier, Zoltan Fekete, Shoji Takeuchi, Oliver Paul  3D arrays of microcages by two-photon lithography for spatial organization of living cells  Lab Chip   2019  19(5):875-884  PubMed ID: 30723853
12328  Ikeda T, Ichikawa K, Shigeto H, Ishida T, Hirota R, Funabashi H, Kuroda A.  Arginine-mediated dissociation of single cells and cell sheets from a polystyrene culture dish  Biosci Biotechnol Biochem  2019  83(12):2272-2275  PubMed ID: 31482750
12361  Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.  Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy  J Neurochem  2019  148(3):373-385  PubMed ID: 30295925
12550  Taniguchi A, Sawazaki T, Shimizu Y, Sohma Y, Kanai M.  Photophysical properties and application in live cell imaging of B,B-fluoro-perfluoroalkyl BODIPYs  Medchemcomm  2019  0(7):1121-1125  PubMed ID: 31391884
12551  Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.  Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice  J Cell Mol Med  2019  23(9):6283-6294  PubMed ID: 31257716
12552  Masukawa D, Yamada K, Goshima Y.  Overexpression of the gene product of ocular albinism 1 (GPR143/OA1) but not its mutant forms inhibits neurite outgrowth in PC12 cells  J Pharmacol Sci  2019  141(1):41-48  PubMed ID: 31606330
10415  Mizukami-Murata S, Fujita K, Nakano T.  Effect of lower chlorinated hydroxylated-polychlorobiphenyls on development of PC12 cells.  Environ Sci Pollut Res Int  2018  25(17):16434-16445  PubMed ID: 28695493
10540  Terada K, Matsushima Y, Matsunaga K, Takata J, Karube Y, Ishige A, Chiba K.  The Kampo medicine Yokukansan (YKS) enhances nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.  Bosn J Basic Med Sci  2018  18(3):224-233  PubMed ID: 28961087
10615  Ishii N, Tsubouchi H, Miura A, Yanagi S, Ueno H, Shiomi K, Nakazato M.  Ghrelin alleviates paclitaxel-induced peripheral neuropathy by reducing oxidative stress and enhancing mitochondrial anti-oxidant functions in mice.  Eur. J. Pharmacol.  2018  819:35-42  PubMed ID: 29154935
10699  Murata T, Yamaguchi M, Kohno S, Takahashi C, Kakimoto M, Sugimura Y, Kamihara M, Hikita K, Kaneda N.  Regucalcin confers resistance to amyloid-β toxicity in neuronally differentiated PC12 cells.  FEBS Open Bio  2018  8:349-360  PubMed ID: 29511612
10765  Sakagami H, Tsuji M, Tomomura M, Masuda Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Tomomura A, Yokose S, Takeshima H, Natori T, Horiuchi M, Fujisawa T, Kiuchi Y, Oguchi K, Yasui T, Oizumi H, Oizumi T.  Protection of Differentiating Neuronal Cells from Amyloid β Peptide-induced Injury by Alkaline Extract of Leaves of Sasa senanensis Rehder.  In Vivo  2018  32:231-239  PubMed ID: 29475904
11111  Sakagami H, Hara Y, Shi H, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Change in Anticancer Drug Sensitivity During Neuronal Differentiation of PC12 Cells.  In Vivo  2018  32(4):765-770  PubMed ID: 29936457
11143  Mohara M, Kawasaki T, Owada R, Imai T, Kanetaka H, Izumi SI, Tsukiyama K, Nakamura K.  Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells.  Neurosci. Lett.  2018  685:42-4  PubMed ID: 30044955
11215  Oguro A, Inoue T, Kudoh SN, Imaoka S.  14,15-epoxyeicosatrienoic acid produced by cytochrome P450s enhances neurite outgrowth of PC12 and rat hippocampal neuronal cells.  Pharmacol Res Perspect  2018    PubMed ID: 30237892
11214  Koh I, Furusawa K, Haga H.  Anisotropic Multi-channel Collagen Gel (MCCG) Guides the Growth Direction of the Neurite-like Processes of PC12 Cells.  Sci Rep  2018    PubMed ID: 30224813
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454
11255  Sano A, Shi H, Suzuki R, Shirataki Y, Sakagami H.  Change in Amino Acid Pools During Neuronal Differentiation of PC12 Cells.  In Vivo  2018    PubMed ID: 30348694
11277  Nishizaki T.  Profilin facilitates PKCε activation by accelerating ATP supply.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30392913
11344  Terada K, Migita K, Matsushima Y, Sugimoto Y, Kamei C, Matsumoto T, Mori M, Matsunaga K, Takata J, Karube Y.  Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.  PLoS ONE  2018    PubMed ID: 30557385
4436    Enhancement of PC12 axonal extension via hybrid electromagnetic and mechanical stimulation  The Japan Society of Mechanical Engineers  2018  13,18-00024-18-00024 
4315  Sun Z, Liu Y, Kong X, Wang R, Xu Y, Shang C, Huo J, Huang M, Zhao F, Bian K, Zhang S, Tu Y, Chen X.  Exendin-4 Plays a Protective Role in a Rat Model of Spinal Cord Injury Through SERCA2.  Cell. Physiol. Biochem.  2018    PubMed ID: 29794460
4316  Sakagami H, Shi H, Bandow K, Tomomura M, Tomomura A, Horiuchi M, Fujisawa T, Oizumi T.  Search of Neuroprotective Polyphenols Using the "Overlay" Isolation Method.  Molecules  2018    PubMed ID: 30042342
4317  Nishizaki T.  IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway.  Heliyon  2018    PubMed ID: 30533546
4381  Ohta M, Chosa N, Kyakumoto S, Yokota S, Okubo N, Nemoto A, Kamo M, Joh S, Satoh K, Ishisaki A.  IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals.  Int. J. Mol. Med.  2018  42(3):1484-1494  PubMed ID: 29901090
4495  Masami Ishido  An Overview of Development of Quantitative Neurotoxicity Testing In vitro  Journal of Applied Life Sciences International  2018  19(2):1-9 
12549  Hsing‐An Lin, Bo Zhu, Yu‐Wei Wu, Jun Sekine, Aiko Nakao, Shyh‐Chyang Luo, Yoshiro Yamashita, Hsiao‐Hua Yu  Dynamic Poly(3,4‐ethylenedioxythiophene)s Integrate Low Impedance with Redox‐Switchable Biofunction  Advanced Functional Materials  2018  28 
14539  Takanobu Haccho, Hiroshi Ichikawa, Koji Yamamoto, Yusuke Morita, Eiji Nakamachi  Development of Chemotherapy System Using Plasma Activated Medium to Enhance PC12 Axonal Extension  Biomedical and Biotechnology Engineering  2018  3 
14543  Mizuki Fujiwara, Kyoichi Ono, Takashi K. Saito  Photo-Oxidative Cell Membrane Perforation and Applied Cellular Level Neural Interface and Electrophysiological Recording in Animal Cells  2018 International Symposium on Micro-NanoMechatronics and Human Science (MHS)  2018   
9769  Yoshida S, Yamamoto N, Wada N, Tomokiyo A, Hasegawa D, Hamano S, Mitarai H, Monnouchi S, Yuda A, Maeda H.  GDNF From Human Periodontal Ligament Cells Treated With Pro-Inflammatory Cytokines Promotes Neurocytic Differentiation of PC12 Cells.  J. Cell. Biochem.  2017  118:699-708  PubMed ID: 27463736
9780  Uesugi S, Muroi M, Kondoh Y, Shiono Y, Osada H, Kimura KI.  Allantopyrone A activates Keap1-Nrf2 pathway and protects PC12 cells from oxidative stress-induced cell death.  J. Antibiot.  2017  70:429-434  PubMed ID: 27507633
10129  Hozumi Y, Fujiwara H, Kaneko K, Fujii S, Topham MK, Watanabe M, Goto K.  Diacylglycerol kinase ε localizes to subsurface cisterns of cerebellar Purkinje cells.  Cell Tissue Res.  2017  368:441-458  PubMed ID: 28191598
10182  Mir TA, Shinohara H.  Two-Dimensional Surface Plasmon Resonance Imaging System for Cellular Analysis.  Methods Mol. Biol.  2017  1571:31-46  PubMed ID: 28281248
10391  Shinsuke K, Junya K, Tomonobu U, Yoshiko K, Izumo N, Takahiko S.  Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation.  J. Radiat. Res.  2017  58:809-815  PubMed ID: 29106600
10485  Takahashi N, Onozuka W, Watanabe S, Wakasugi K.  Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth.  FEBS Open Bio  2017  7:1338-1349  PubMed ID: 28904863
10511  Okutani C, Wagatsuma A, Mabuchi K, Hoshino T.  Directed cell migration in co-cultures by topographic curvature for heterogeneous tissue engineering.  Conf Proc IEEE Eng Med Biol Soc  2017  2017:1607-1610  PubMed ID: 29060190
10513  Muroi T, Matsushima Y, Kanamori R, Inoue H, Fujii W, Yogo K.  GPR62 constitutively activates cAMP signaling but is dispensable for male fertility in mice.  Reproduction  2017  154:755-764  PubMed ID: 28912303
10591  Tachizawa S, Takahashi H, Kim YJ, Odawara A, Pauty J, Ikeuchi Y, Suzuki I, Kikuchi A, Matsunaga YT.  Bundle Gel Fibers with a Tunable Microenvironment for in Vitro Neuron Cell Guiding.  ACS Appl Mater Interfaces  2017  9:43250-43257  PubMed ID: 29086563
10598  Sakagami H, Suzuki R, Shirataki Y, Iwama S, Nakagawa M, Suzuki H, Tanaka K, Tamura N, Takeshima H.  Re-evaluation of Culture Condition of PC12 and SH-SY5Y Cells Based on Growth Rate and Amino Acid Consumption.  In Vivo  2017  31:1089-1095  PubMed ID: 29102930
9461  Kyosuke Uno, Toh Miyazaki, Kengo Sodeyama, Yoshiaki Miyamoto, Atsumi Nitta  Methamphetamine Induces Shati/Nat8L Expression in the Mouse Nucleus Accumbens via CREB- And Dopamine D1 Receptor-Dependent Mechanism  PLoS One  2017  12(3):e0174196  PubMed ID: 28319198
12219  Motoshi Komatsubara, Takayuki Hara, Takeshi Hosoya, Kishio Toma, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Kenichi Inagaki, Jun Wada, Fumio Otsuka  Melatonin regulates catecholamine biosynthesis by modulating bone morphogenetic protein and glucocorticoid actions  J Steroid Biochem Mol Biol  2017  165(Pt B):182-189  PubMed ID: 27267863
14383  Tomoko Koda, Jun Takanari, Kentaro Kitadate, Hideki Imai  Enzyme-treated Asparagus Extract (ETAS) Enhances Memory in Normal Rats and Induces Neurite-outgrowth in PC12 Cells  Natural Product Communications  2017  12:1934578X1701201 
14483  Sasaki K, Othman MB, Demura M, Watanabe M, Isoda H.  Modulation of Neurogenesis through the Promotion of Energy Production Activity Is behind the Antidepressant-Like Effect of Colonial Green Alga, Botryococcus braunii  Front Physiol  2017  8:900  PubMed ID: 29176952
14560  Arata Kaneko, , Yuuki Miyazaki, Tatsuya Goto  Transfer-Print of CNTs and its Application to Cell Scaffold  International Journal of Automation Technology  2017  11:941-946 
14566  Villareal MO, Ikeya A, Sasaki K, Arfa AB, Neffati M, Isoda H.  Anti-stress and neuronal cell differentiation induction effects of Rosmarinus officinalis L. essential oil  BMC Complement Altern Med  2017  17(1):549  PubMed ID: 29273038
14589  Serien D, Takeuchi S.  Multi-Component Microscaffold With 3D Spatially Defined Proteinaceous Environment  ACS Biomater Sci Eng  2017  3(3):487-494  PubMed ID: 33465943
7102  Yoshida S, Teshima T, Kuribayashi-Shigetomi K, Takeuchi S.  Mobile Microplates for Morphological Control and Assembly of Individual Neural Cells.  Adv Healthc Mater  2016  5:415-20  PubMed ID: 26712104
7131  Saito Y, Ishii KA, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization.  Neurochem. Res.  2016  41:696-706  PubMed ID: 26620190
7224  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.  Mol. Neurobiol.  2016  53:4787-97  PubMed ID: 26328540
9623  Seki K, Cueno ME, Kamio N, Saito Y, Kamimoto A, Kurita-Ochiai T, Ochiai K.  Varying butyric acid amounts induce different stress- and cell death-related signals in nerve growth factor-treated PC12 cells: implications in neuropathic pain absence during periodontal disease progression.  Apoptosis  2016  21:699-707  PubMed ID: 26994613
9834  Ogra Y, Tejima A, Hatakeyama N, Shiraiwa M, Wu S, Ishikawa T, Yawata A, Anan Y, Suzuki N.  Changes in intracellular copper concentration and copper-regulating gene expression after PC12 differentiation into neurons.  Sci Rep  2016  6:33007  PubMed ID: 27623342
9848  Mizukami-Murata S, Sakakibara F, Fujita K, Fukuda M, Kuramata M, Takagi K.  Detoxification of hydroxylated polychlorobiphenyls by Sphingomonas sp. strain N-9 isolated from forest soil.  Chemosphere  2016  165:173-182  PubMed ID: 27649311
9906  Yao W, Zhang JC, Ishima T, Ren Q, Yang C, Dong C, Ma M, Saito A, Honda T, Hashimoto K.  Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression.  Eur. J. Pharmacol.  2016  793:21-27  PubMed ID: 27815170
10856  Fujimura M, Usuki F, Cheng J, Zhao W.  Prenatal low-dose methylmercury exposure impairs neurite outgrowth and synaptic protein expression and suppresses TrkA pathway activity and eEF1A1 expression in the rat cerebellum  Toxicol Appl Pharmacol  2016  298:1-8  PubMed ID: 26965727
10925    Limonene Enhances the cAMP Response Element (CRE)-Dependent Transcriptional Activity Activated via Adenosine A2 A Receptor in a Neural-Crest Derived Cell Line, PC-12  Planta Med Int Open  2016  3: e60–e63 
10927  Naoto Ito ; Naoto Konno ; Takashi K. Saito  Sub-micrometer-scale wire-based intracellular metal microelectrode  IEEE Xplore  2016   
12904  Shindo Y, Iwamoto K, Mouri K, Hibino K, Tomita M, Kosako H, Sako Y, Takahashi K.  Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling  Nat Commun  2016  7:10485  PubMed ID: 26786866
13470  Takito J, Kimura J, Kajima K, Uozumi N, Watanabe M, Yokosuka A, Mimaki Y, Nakamura M, Ohizumi Y.  Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells  Can J Physiol Pharmacol  2016  94(7):728-33.  PubMed ID: 27128150
13979  Ito T, Hayashida M, Kobayashi S, Muto N, Hayashi A, Yoshimura T, Mori H.  Serine racemase is involved in d-aspartate biosynthesis  J Biochem  2016  160(6):345-353  PubMed ID: 27387750
13982  Zeng B, Li Y, Niu B, Wang X, Cheng Y, Zhou Z, You T, Liu Y, Wang H, Xu J.  Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells  J Mol Neurosci  2016  59(4):567-78  PubMed ID: 27412469
14101  Iwori Takeda, Masato Kawanabe, Arata Kaneko  An investigation of cell adhesion and growth on micro/nano-scale structured surface—Self-assembled micro particles as a scaffold  Precision Engineering  2016  43:294-298 
14112  Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K.  Altered expression of Mg(2+) transport proteins during Parkinson's disease-like dopaminergic cell degeneration in PC12 cells  Biochim Biophys Acta  2016  1863(8):1979-84  PubMed ID: 27157538
14121  Sharma G, Tsutsumi K, Saito T, Asada A, Ando K, Tomomura M, Hisanaga SI.  Kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons  Genes Cells  2016  21(10):1080-1094  PubMed ID: 27600567
14167  Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Suganuma H, Ushida Y, Yamamoto M, Hashimoto K.  Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice  Sci Rep  2016  ;6:30659  PubMed ID: 27470577
14173  Ren Q, Ma M, Ishima T, Morisseau C, Yang J, Wagner KM, Zhang JC, Yang C, Yao W, Dong C, Han M, Hammock BD, Hashimoto K.  Gene deficiency and pharmacological inhibition of soluble epoxide hydrolase confers resilience to repeated social defeat stress  Proc Natl Acad Sci U S A  2016  113(13):E1944-52  PubMed ID: 26976569
14186  Iwori TAKEDA, Shogo SERIZAWA, Arata KANEKO  Fabrication of micro-structured scaffold using self-assembled particles and effects of surface geometries on cell adhesion  Mechanical Engineering Journal  2016  3:15-00521-15-00521 
7123  Sawaguchi Y, Ueno S, Nishiyma Y, Yamazaki R, Matsuzaki T.  Establishment of a Novel In Vitro Model for Predicting Incidence and Severity of Microtubule-targeting Agent-induced Peripheral Neuropathy.  Anticancer Res.  2015  35:6431-7  PubMed ID: 26637853
7160  Jin Y, Tsuchiya A, Kanno T, Nishizaki T.  Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.  Biochem. Biophys. Res. Commun.  2015  468:157-60  PubMed ID: 26522221
7228  Xia B, Liu H, Xie J, Wu R, Li Y.  Akt enhances nerve growth factor-induced axon growth via activating the Nrf2/ARE pathway.  Int. J. Mol. Med.  2015  36:1426-32  PubMed ID: 26324295
7364  Arai Y, Yamamoto T, Minamikawa T, Takamatsu T, Nagai T.  Spectral fingerprinting of individual cells visualized by cavity-reflection-enhanced light-absorption microscopy.  PLoS ONE  2015  10:e0125733  PubMed ID: 25950513
7423  Cueno ME, Kamio N, Seki K, Kurita-Ochiai T, Ochiai K.  High butyric acid amounts induce oxidative stress, alter calcium homeostasis, and cause neurite retraction in nerve growth factor-treated PC12 cells.  Cell Stress Chaperones  2015  20:709-13  PubMed ID: 25808460
7454  Takeda I, Kawanabe M, Kaneko A.  Autonomous patterning of cells on microstructured fine particles.  Mater Sci Eng C Mater Biol Appl  2015  50:173-8  PubMed ID: 25746259
7499  Uemura M, Ishiguro H.  Freezing behavior of adherent neuron-like cells and morphological change and viability of post-thaw cells.  Cryobiology  2015  70:122-35  PubMed ID: 25645578
7527  Florian Larramendy, Daniela Serien, Shotaro Yoshida, Laurent Jalabert, Shoji Takeuchi, Oliver Paul.  High-topography surface functionalization based on parylene-C peel-off for patterned cell growth.  2015 28th IEEE International Conference on MEMS  2015  328-331 
7578  Ghimire Gautam S, Komatsu M, Nishigaki K.  Strong inhibition of beta-amyloid peptide aggregation realized by two-steps evolved peptides.  Chem Biol Drug Des  2015  85:356-68  PubMed ID: 25082146
5314  Bahrini I, Song JH, Diez D, Hanayama R.  Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia.  Sci Rep  2015  5:7989  PubMed ID: 25612542
6007  Shindo Y, Yamanaka R, Suzuki K, Hotta K, Oka K.  Intracellular magnesium level determines cell viability in the MPP(+) model of Parkinson's disease.  Biochim Biophys Acta  2015  853(12):3182-91  PubMed ID: 26319097
9474  Masatake Fujimura, Fusako Usuki  Methylmercury Causes Neuronal Cell Death Through the Suppression of the TrkA Pathway: In Vitro and in Vivo Effects of TrkA Pathway Activators  Toxicol Appl Pharmacol  2015  282(3):259-66  PubMed ID: 25545984
14970  Ishima T, Futamura T, Ohgi Y, Yoshimi N, Kikuchi T, Hashimoto K.  Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors  Eur Neuropsychopharmacol  2015  25(4):505-11  PubMed ID: 25687838
15043  Yamagishi M, Hosoda-Yabe R, Tamai H, Konishi M, Imamura A, Ishida H, Yabe T, Ando H, Kiso M.  Structure-Activity Relationship Study of the Neuritogenic Potential of the Glycan of Starfish Ganglioside LLG-3 (‡)  Mar Drugs  2015  13(12):7250-74  PubMed ID: 26690179
15172  Kenta Goto, Tatsuya Suzuki, Hideki Tamai, Junya Ogawa, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Makoto Kiso  Total Synthesis and Neuritogenic Activity Evaluation of Ganglioside PNG-2A from the StarfishProtoreaster nodosus  Asian Journal of Organic Chemistry  2015  4:1160-1171 
15243  Kakinoki S, Seo JH, Inoue Y, Ishihara K, Yui N, Yamaoka T.  Mobility of the Arg-Gly-Asp ligand on the outermost surface of biomaterials suppresses integrin-mediated mechanotransduction and subsequent cell functions  Acta Biomater  2015  13:42-51  PubMed ID: 25463493
15481  Fujita S, Ushio S, Ozawa N, Masuguchi K, Kawashiri T, Oishi R, Egashira N.  Exenatide Facilitates Recovery from Oxaliplatin-Induced Peripheral Neuropathy in Rats  PLoS One  2015  10(11):e0141921  PubMed ID: 26536615
14964  Yamamoto S, Kawashiri T, Higuchi H, Tsutsumi K, Ushio S, Kaname T, Shirahama M, Egashira N.  Behavioral and pharmacological characteristics of bortezomib-induced peripheral neuropathy in rats  J Pharmacol Sci  2015  129(1):43-50  PubMed ID: 26362518
7583  Takaaki Mori, Yukihiro Akiyama, Shogo Unuma, Takashi K. Saito.  High performance cell membrane perforation system for cell suspensions.  Micro-NanoMechatronics and Human Science (MHS), 2014 International Symposium on  2014  1-3 
15809  Takahashi K, Yokota M, Ohta T.  Molecular mechanism of 2-APB-induced Ca²⁺ influx in external acidification in PC12  Exp Cell Res  2014  323(2):337-45  PubMed ID: 24630903
15821  Hiromichi NAKADATE, Yohei FUKUMURA, Yuma KANEKO, Akira KAKUTA, Hidenori FURUKAWA, Shigeru AOMURA  In vitro uniaxial stretch model for evaluating the effect of strain along axon on damage to neurons  Journal of Biomechanical Science and Engineering  2014  9:14-00136-14-00136 
15854  Matsui T, Yoshida Y, Yanagihara M, Suenaga H.  Hypothermia at 35 °C reduces the time-dependent microglial production of pro-inflammatory and anti-inflammatory factors that mediate neuronal cell death  Neurocrit Care  2014  20(2):301-10  PubMed ID: 24072458
15855  Kakinoki S, Nakayama M, Moritan T, Yamaoka T.  Three-layer microfibrous peripheral nerve guide conduit composed of elastin-laminin mimetic artificial protein and poly(L-lactic acid)  Front Chem  2014  2:52  PubMed ID: 25101261
15856  Kakinoki S , Yamaoka T .  Thermoresponsive elastin/laminin mimicking artificial protein for modifying PLLA scaffolds in nerve regeneration  J Mater Chem B  2014  2(31):5061-5067.  PubMed ID: 32261839
15857  Tsuchiya A, Nagaya H, Kanno T, Nishizaki T.  Oleic acid stimulates glucose uptake into adipocytes by enhancing insulin receptor signaling  J Pharmacol Sci  2014  126(4):337-43  PubMed ID: 25391857
17156  H. Nakadate, S. Aomura, A. Kakuta  An in Vitro Stretch-Injury Model for Elongation-Controlled Neuronal Cells: Effect of Strains Along Neurite  IFMBE Proceedings  2014  756-759 
15765  Mouri K, Sako Y.  Optimality conditions for cell-fate heterogeneity that maximize the effects of growth factors in PC12 cells  PLoS Comput Biol  2013  9(11):e1003320  PubMed ID: 24244131
15929  Shinohara H, Sakai Y, Mir TA.  Real-time monitoring of intracellular signal transduction in PC12 cells by two-dimensional surface plasmon resonance imager  Anal Biochem  2013  441(2):185-9  PubMed ID: 23891634
15957  Tatsuki SUGIHARA, Arata KANEKO  Self-Patterning of PC12 Cells on Micro-Structures of Protein-Modified Particles  Journal of Solid Mechanics and Materials Engineering  2013  7:142-154 
15959  Tomono S, Yasue Y, Miyoshi N, Ohshima H.  Cytotoxic effects of secosterols and their derivatives on several cultured cells  Biosci Biotechnol Biochem  2013  77(3):651-3  PubMed ID: 23470737
15960  Kanno T, Tsuchiya A, Tanaka A, Nishizaki T.  The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner  Biochem J  2013  450(2):303-9  PubMed ID: 23256752
15961  Nishimoto T, Kanno T, Shimizu T, Tanaka A, Nishizaki T.  Regulation of GluA1 AMPA receptor through PKC phosphorylation induced by free fatty acid derivative HUHS2002  Lipids  2013  48(1):23-8  PubMed ID: 23117296
15962  Kouhei Horikawa, Takuya Yagyu, Yukio Yoshioka, Takeshi Fujiwara, Akihiko Kanamoto, Tetsuji Okamoto, Makoto Ojika  Petrosiols A–E, neurotrophic diyne tetraols isolated from the Okinawan sponge Petrosia strongylata  Tetrahedron  2013  69:101-106 
15963  Tekin M, Chioza BA, Matsumoto Y, Diaz-Horta O, Cross HE, Duman D, Kokotas H, Moore-Barton HL, Sakoori K, Ota M, Odaka YS, Foster J 2nd, Cengiz FB, Tokgoz-Yilmaz S, Tekeli O, Grigoriadou M, Petersen MB, Sreekantan-Nair A, Gurtz K, Xia XJ, Pandya A, Patton MA, Young JI, Aruga J, Crosby AH.  SLITRK6 mutations cause myopia and deafness in humans and mice  J Clin Invest   2013  123(5):2094-102  PubMed ID: 23543054
7641  Hoshino T, Saito I, Takano H, Samejima K, Mabuchi K, Kato YX.  Neurite outgrowth of PC12 cells on diX (parylene) family materials.  Biotechnol Prog  2012  28:587-90  PubMed ID: 22052685
7700  Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib induces apoptosis in pheochromocytoma tumor cells by inhibiting VEGFR2/Akt/mTOR/S6K1 pathways through modulation of Bcl-2 and BAD.  Am. J. Physiol. Endocrinol. Metab.  2012  302:E615-25  PubMed ID: 21878661
6172  E L Omri A, Han J, Ben Abdrabbah M, Isoda H.  Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells.  Cytotechnology  2012  64(3):231-40  PubMed ID: 21861121
9091  Punnee Nusuetrong, Masaki Saito, Haruhisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, Norimichi Nakahata  Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-Stranded Break in PC12 Cells  J Toxicol Sci  2012  37 (4), 803-12  PubMed ID: 22863859
15744  Hiromichi NAKADATE, Hiroto UMAHASHI, Akira KAKUTA, Shigeru AOMURA  Progression to Cell Death Correlates with Neurite Swelling Induced by Stretch Injury  Journal of Biomechanical Science and Engineering  2012  7:406-415 
15964  El Omri A, Han J, Kawada K, Ben Abdrabbah M, Isoda H.  Luteolin enhances cholinergic activities in PC12 cells through ERK1/2 and PI3K/Akt pathways  Brain Res  2012  1437:16-25  PubMed ID: 22226506
15965  Ishima T, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors  PLoS One  2012  7(5):e37989  PubMed ID: 22655093
15966  Masumi Yamada, Sari Sugaya, Yoji Naganuma, Minoru Seki  Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking  Soft Matter  2012  8:3122 
15967  Iwori Takeda, Arata Kaneko, Yasuhiro Tanaka, Nobuyuki Moronuki  Selective Cell-Adhesion on Micro-Structured Fine Particles  Key Engineering Materials  2012  516:130-135 
15968  Aita Y, Ishii KA, Saito Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K.  Sunitinib inhibits catecholamine synthesis and secretion in pheochromocytoma tumor cells by blocking VEGF receptor 2 via PLC-γ-related pathways  Am J Physiol Endocrinol Metab  2012  303(8):E1006-14  PubMed ID: 22912364
7590  Irie K, Murakami K, Masuda Y, Murata N, Noda Y, Hatsuta H, Murayama S, Shimizu T, Horikoshi Y, Kinoshita N, Shirasawa T.  [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].  Rinsho Shinkeigaku  2011  51:890-1  PubMed ID: 22277406
7619  Hoshino T, Saito I, Kometani R, Samejima K, Matsui S, Suzuki T, Mabuchi K, Kato YX.  Improvement of neuronal cell adhesiveness on parylene with oxygen plasma treatment.  J. Biosci. Bioeng.  2011  113:395-8  PubMed ID: 22138385
7720  Toda T, Sunagawa T, Kanda T, Tagashira M, Shirasawa T, Shimizu T.  Apple Procyanidins Suppress Amyloid β-Protein Aggregation.  Biochem Res Int  2011  2011:784698  PubMed ID: 21826271
7737  Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A.  A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease.  Biomicrofluidics  2011  5:22214  PubMed ID: 21799720
7795  Kishimoto E, Naito Y, Handa O, Okada H, Mizushima K, Hirai Y, Nakabe N, Uchiyama K, Ishikawa T, Takagi T, Yagi N, Kokura S, Yoshida N, Yoshikawa T.  Oxidative stress-induced posttranslational modification of TRPV1 expressed in esophageal epithelial cells.  Am. J. Physiol. Gastrointest. Liver Physiol.  2011  301:G230-8  PubMed ID: 21636531
7803  Sohma Y, Wang H, Taniguchi A, Hirayama Y, Kakizawa T, Yamasaki M, Mukai H, Kiso Y.  Self-assembly pathways of E22Δ-type amyloid β peptide mutants generated from non-aggregative O-acyl isopeptide precursors.  Bioorg. Med. Chem.  2011  19:3787-92  PubMed ID: 21612934
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973
7889  Hashimoto K, Ishima T.  Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol.  PLoS ONE  2011  6:e17431  PubMed ID: 21390260
7913  Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.  Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H2O2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.  Bioorg. Med. Chem.  2011  19:1959-65  PubMed ID: 21345685
7923  Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H.  Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform.  Chembiochem  2011  12:795-801  PubMed ID: 21341350
7932  Yabe T, Hosoda-Yabe R, Kanamaru Y, Kiso M.  A peptide found by phage display discriminates a specific structure of a trisaccharide in heparin.  J. Biol. Chem.  2011  286:12397-406  PubMed ID: 21335559
7945  Shimizu T, Kanno T, Tanaka A, Nishizaki T.  α, β-DCP-LA selectively activates PKC-ε and stimulates neurotransmitter release with the highest potency among 4 diastereomers.  Cell. Physiol. Biochem.  2011  27:149-58  PubMed ID: 21325832
7965  Onoue S, Kuriyama K, Uchida A, Mizumoto T, Yamada S.  Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity.  Pharm. Res.  2011  28:1157-66  PubMed ID: 21287249
8003  Itoh K, Ishima T, Kehler J, Hashimoto K.  Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.  Brain Res.  2011  1377:32-40  PubMed ID: 21211516
8020  Shen J, Maruyama IN.  Nerve growth factor receptor TrkA exists as a preformed, yet inactive, dimer in living cells.  FEBS Lett.  2011  585:295-9  PubMed ID: 21187090
8023  Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO.  The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.  J Ethnopharmacol  2011  134:313-22  PubMed ID: 21172413
8090  Maezawa Y, Okano K, Matsubara M, Masuhara H, Hosokawa Y.  Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force.  Biomed Microdevices  2011  13:117-22  PubMed ID: 20949320
8097  Ito Y, Kimura T, Nam K, Katoh A, Masuzawa T, Kishida A.  Effects of vibration on differentiation of cultured PC12 cells.  Biotechnol. Bioeng.  2011  108:592-9  PubMed ID: 20939009
8134  Takadera T, Koriyama Y, Kimura T, Kato S.  5-S-GAD attenuates Fe2+-induced lipid peroxidation and cell death in a neuronal cell model.  Neurotox Res  2011  20:26-31  PubMed ID: 20809179
6146  Shyh‐Chyang Luo Bo Zhu Aiko Nakao Reiko Nakatomi Hsiao‐hua Yu  Functionalized Conducting Polymer Nano‐Networks from Controlled Oxidation Polymerization toward Cell Engineering  Advanced Engineering Materials  2011  13:B423-B427 
15714  Shindo Y, Fujii T, Komatsu H, Citterio D, Hotta K, Suzuki K, Oka K.  Newly developed Mg2+-selective fluorescent probe enables visualization of Mg2+ dynamics in mitochondria  PLoS One  2011  e23684  PubMed ID: 21858208
16310  Kudo TA, Kanetaka H, Mizuno K, Ryu Y, Miyamoto Y, Nunome S, Zhang Y, Kano M, Shimizu Y, Hayashi H.  Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway  Genes Cells  2011  16(11):1121-32  PubMed ID: 21988724
8030  Hashimoto K, Ishima T.  A novel target of action of minocycline in NGF-induced neurite outgrowth in PC12 cells: translation initiation [corrected] factor eIF4AI.  PLoS ONE  2010  5:e15430  PubMed ID: 21151481
8053  Murakami K, Horikoshi-Sakuraba Y, Murata N, Noda Y, Masuda Y, Kinoshita N, Hatsuta H, Murayama S, Shirasawa T, Shimizu T, Irie K.  Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.  ACS Chem Neurosci  2010  1:747-56  PubMed ID: 22778811
8057  Murata N, Murakami K, Ozawa Y, Kinoshita N, Irie K, Shirasawa T, Shimizu T.  Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.  Biosci. Biotechnol. Biochem.  2010  74:2299-306  PubMed ID: 21071836
8116  Minase T, Ishima T, Itoh K, Hashimoto K.  Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP? receptors.  Eur. J. Pharmacol.  2010  648:67-73  PubMed ID: 20854802
8124  Yaguchi T, Nagata T, Nishizaki T.  1,2-dilinoleoyl-sn-glycero-3-phosphoethanolamine ameliorates age-related spatial memory deterioration by preventing neuronal cell death.  Behav Brain Funct  2010  6:52  PubMed ID: 20831835
8157  Zeng KW, Ko H, Yang HO, Wang XM.  Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.  Neuropharmacology  2010  59:542-50  PubMed ID: 20708632
8211  Okuyama T, Yamazoe H, Mochizuki N, Khademhosseini A, Suzuki H, Fukuda J.  Preparation of arrays of cell spheroids and spheroid-monolayer cocultures within a microfluidic device.  J. Biosci. Bioeng.  2010  110:572-6  PubMed ID: 20591731
8234  Okuyama T, Yamazoe H, Seto Y, Suzuki H, Fukuda J.  Cell micropatterning inside a microchannel and assays under a stable concentration gradient.  J. Biosci. Bioeng.  2010  110:230-7  PubMed ID: 20547384
8318  Goto E, Mukozawa M, Mori H, Hara M.  A rolled sheet of collagen gel with cultured Schwann cells: model of nerve conduit to enhance neurite growth.  J. Biosci. Bioeng.  2010  109:512-8  PubMed ID: 20347776
8322  Zeng KW, Wang XM, Ko H, Yang HO.  Neuroprotective effect of modified Wu-Zi-Yan-Zong granule, a traditional Chinese herbal medicine, on CoCl2-induced PC12 cells.  J Ethnopharmacol  2010  130:13-8  PubMed ID: 20347949
8333  Takadera T, Nakajima Y, Kanai Y.  Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:863-8  PubMed ID: 20300959
8392  Oyane A, Tsurushima H, Ito A.  Highly efficient gene transfer system using a laminin-DNA-apatite composite layer.  J Gene Med  2010  12:194-206  PubMed ID: 20082421
8405  Yasuyo Maezawa, Yoichiroh Hosokawa, Kazunori Okano, Mie Matsubara and Hiroshi Masuhara  In situ observation of cell-detachment process initiated by femtosecond laser-induced stress wave  Applied Physics A: Materials Science & Processing  2010  101:127-131 
8414  Aita Y, Kasahara T, Isobe K, Kawakami Y, Takekoshi K.  Effect of urotensin II on PC12 rat pheochromocytoma cells.  J. Neuroendocrinol.  2010  22:83-91  PubMed ID: 20025629
8427  Kakinoki S, Yamaoka T.  Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence.  Acta Biomater  2010  6:1925-30  PubMed ID: 19969110
8511  Takadera T, Ohtsuka M, Aoki H.  Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.  Cell. Mol. Neurobiol.  2010  30:193-8  PubMed ID: 19688259
15563  Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN.  Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics  Cell  2010  141(5):884-9  PubMed ID: 20493519
15694  Yuelin ZHANG, Shigeru AOMURA, Kiyoto FURUSE, Akira KAKUTA, Satoshi FUJIWARA, Ayako NASU  Study on Impact Resistance of PC12 Cells  Journal of Biomechanical Science and Engineering  2010  5:119-128 
8518  Kato YX, Saito I, Takano H, Mabuchi K, Hoshino T.  Comparison of neuronal cell adhesiveness of materials in the diX (Parylene) family.  Neurosci. Lett.  2009  464:26-8  PubMed ID: 19664682
8544  Ohnuma K, Toyota T, Ariizumi T, Sugawara T, Asashima M.  Directional migration of neuronal PC12 cells in a ratchet wheel shaped microchamber.  J. Biosci. Bioeng.  2009  108:76-83  PubMed ID: 19577197
8556  Hamada N, Fujita Y, Tanaka A, Naoi M, Nozawa Y, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Ito M.  Metabolites of sesamin, a major lignan in sesame seeds, induce neuronal differentiation in PC12 cells through activation of ERK1/2 signaling pathway.  J Neural Transm (Vienna)  2009  116:841-52  PubMed ID: 19533291
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15697  Atsushi Kira, Kazunori Okano, Yoichiroh Hosokawa, Akira Naito, Koh Fuwa, Jyunpei Yuyama, Hiroshi Masuhara  Micropatterning of perfluoroalkyl self-assembled monolayers for arraying proteins and cells on chips  Applied Surface Science  2009  255:7647-7651 
15698  Sumiko Iwasa, Akina Enomoto, Satomi Onoue, Minako Nakai, Takehiko Yajima, Takeshi Fukushima  Chromatographic Analysis of Conformationally Changed Insulin and Its Cytotoxic Effect on PC12 Cells  Journal of Health Science  2009  55:825-831 
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