CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB0007 : HeLa]

1446 J E DARNELL Jr, T K SAWYERc Variation in plaque-forming ability among parental and clonal strains of HeLa cells Virology 1959 223-9 PubMed ID: 13669339 DOI: 10.1016/0042-6822(59)90006-6

4660 EAGLE H. The minimum vitamin requirements of the L and HeLa cells in tissue culture, the production of specific vitamin deficiencies, and their cure. J Exp Med 1955 102(5):595-600 PubMed ID: 13271674 DOI: 10.1084/jem.102.5.595

1444 Puck TT1, Marcus PI. A RAPID METHOD FOR VIABLE CELL TITRATION AND CLONE PRODUCTION WITH HELA CELLS IN TISSUE CULTURE: THE USE OF X-IRRADIATED CELLS TO SUPPLY CONDITIONING FACTORS. Proc Natl Acad Sci U S A 1955 41(7):432-7 PubMed ID: 16589695 DOI: 10.1073/pnas.41.7.432

150 Gey,G.O., Coffman,W.D. and Kubicek,M.T. Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res 1952 12:264-265

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19811 Une S, Nakata R, Nonaka K, Akiyama J. Antiproliferative and anti-inflammatory effects of fractionated crude lectins from boiled kidney beans (Phaseolus vulgaris) J Food Sci 2024 89(1):671-683 PubMed ID: 37983860 DOI: 10.1111/1750-3841.16847

21542 Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A. RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality. J Am Chem Soc 2024 PubMed ID: 38170469 DOI: 10.1021/jacs.3c09524

21645 Tojima T, Suda Y, Jin N, Kurokawa K, Nakano A. Spatiotemporal dissection of the Golgi apparatus and the ER-Golgi intermediate compartment in budding yeast. Elife 2024 13 PubMed ID: 38501165 DOI: 10.7554/eLife.92900

21649 Tsuchida A, Kaneko T, Nishikawa K, Kawasaki M, Yokokawa R, Shintaku H. Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes. Lab Chip 2024 PubMed ID: 38506394 DOI: 10.1039/d3lc00866e

17602 Someya Y, Kobayashi S, Toriumi K, Takeda S, Adachi N, Kurosawa A. A Cell System-Assisted Strategy for Evaluating the Natural Antioxidant-Induced Double-Stranded DNA Break (DSB) Style Genes (Basel) 2023 14(2):420 PubMed ID: 36833347 DOI: 10.3390/genes14020420

17619 Ebata H, Umeda K, Nishizawa K, Nagao W, Inokuchi S, Sugino Y, Miyamoto T, Mizuno D. Activity-dependent glassy cell mechanics Ⅰ: Mechanical properties measured with active microrheology Biophys J 2023 ;S0006-3495(23)00241-2 PubMed ID: 37050875 DOI: 10.1016/j.bpj.2023.04.011

17786 Nakagawa Y, Hishida T, Sumaru K, Morishita K, Kirito K, Yokojima S, Sakamoto Y, Nakamura S, Uchida K. Phototunable Cell Killing by Photochromic Diarylethene of Thiazoyl and Thienyl Derivatives J Med Chem 2023 ;66(8):5937-5949 PubMed ID: 37128763 DOI: 10.1021/acs.jmedchem.3c00164

17799 Zhu Z, Kitano T, Morimatsu M, Ochiai K, Ishiguro-Oonuma T, Oosumi K, Lin X, Orino K, Yoshikawa Y. A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats Vet Sci 2023 10(2):145 PubMed ID: 36851449 DOI: 10.3390/vetsci10020145

17801 Ryo Kobori, Ryo Doge, Momoka Takae, Atoru Aoki, Takashi Kawasaki, Akiko Saito Potential of Raspberry Flower Petals as a Rich Source of Bioactive Flavan-3-ol Derivatives Revealed by Polyphenolic Profiling Nutraceuticals 2023 3:196-209 DOI: 10.3390/nutraceuticals3020015

17804 Toshiki Takahashi, Jun Shirai, Miyo Matsuda, Sae Nakanaga, Shin Matsushita, Kei Wakita, Mizuki Hayashishita, Rigel Suzuki, Aya Noguchi, Naoto Yokota, and Hiroyuki Kawahara Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8- family GTPases iScience 2023 DOI: 10.1016/ j.isci.2023.106652

19599 Sakamoto K, Uchiyama K, Iwasaki T, Inaba H, Matsuura K. An artificial viral capsid decorated with a DNA aptamer internalizing into lymphoma cells J Mater Chem B 2023 11(26):6053-6059 PubMed ID: 37310262 DOI: 10.1039/d3tb00169e

19609 Takano T, Kudo H, Eguchi S, Matsumoto A, Oka K, Yamasaki Y, Takahashi M, Koshikawa T, Takemura H, Yamagishi Y, Mikamo H, Kunishima H. Inhibitory effects of vaginal Lactobacilli on C andida albicans growth, hyphal formation, biofilm development, and epithelial cell adhesion Front Cell Infect Microbiol 2023 13:1113401 PubMed ID: 37201113 DOI: 10.3389/fcimb.2023.1113401

19619 Yokosawa T, Wakasugi K. Tryptophan-Starved Human Cells Overexpressing Tryptophanyl-tRNA Synthetase Enhance High-Affinity Tryptophan Uptake via Enzymatic Production of Tryptophanyl-AMP Int J Mol Sci 2023 24(20):15453 PubMed ID: 37895133 DOI: 10.3390/ijms242015453

19651 Ebata H, Shima T, Iizuka R, Uemura S. Accumulation of TERT in mitochondria exerts two opposing effects on apoptosis FEBS Open Bio 2023 13(9):1667-1682 PubMed ID: 37525387 DOI: 10.1002/2211-5463.13682

19653 Kazuaki NAGAYAMA, Tatsuya HANZAWA, Akiko SATO Superficial groove structure in the size of focal adhesion can clarify cell-type-specific differences in force-dependent substrate mechanosensing Journal of Biomechanical Science and Engineering 2023 18:22-00474-22-00474 DOI: 10.1299/jbse.22-00474

19836 Yasuyuki MORITA, Takashi YAMAUCHI, Yusuke NAKANO, Kanau OSHIMA, Yuhki TOKU, Yang JU Epithelial–mesenchymal Transition of HeLa Cells Increases Traction Force to the ECM in 3D Collagen Gel Advanced Experimental Mechanics 2023 8:94-99 DOI: 10.11395/aem.8.0_94

19837 Amemiya T, Shibata K, Yamaguchi T. Metabolic Oscillations and Glycolytic Phenotypes of Cancer Cells Int J Mol Sci 2023 24(15):11914 PubMed ID: 37569294 DOI: 10.3390/ijms241511914

19839 Shou J, Komazawa A, Wachi Y, Kawatani M, Fujioka H, Spratt SJ, Mizuguchi T, Oguchi K, Akaboshi H, Obata F, Tachibana R, Yasunaga S, Mita Y, Misawa Y, Kojima R, Urano Y, Kamiya M, Ozeki Y. Super-resolution vibrational imaging based on photoswitchable Raman probe Sci Adv 2023 9(24):eade9118 PubMed ID: 37327330 DOI: 10.1126/sciadv.ade9118

19843 Zhang M, Fukushima Y, Nozaki K, Nakanishi H, Deng J, Wakabayashi N, Itaka K. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA Inflamm Regen 2023 43(1):32. PubMed ID: 37340499 DOI: 10.1186/s41232-023-00285-3

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

19971 Asuka Inada, Makoto Hitotsumatsu, Tatsuya Oshima Development of Amphiphilic Short Peptides to Control Drug Inclusivity through Metal Complexation Reactions Journal of Chemical Engineering of Japan 2023 56 DOI: 10.1080/00219592.2023.2219291

20972 Tojima T, Miyashiro D, Kosugi Y, Nakano A. Super-Resolution Live Imaging of Cargo Traffic Through the Golgi Apparatus in Mammalian Cells. Methods Mol Biol 2023 2557:127-140 PubMed ID: 36512214 DOI: 10.1007/978-1-0716-2639-9_10

20990 Wang Y, Suzuki R, Fujii A, Ieki K, Goda W, Yasui M, Abe Y. A tyrosine-based YXXΦ motif regulates the degradation of aquaporin-4 via both lysosomal and proteasomal pathways and is functionally inhibited by a ten-amino-acid sequence within its C-terminus. FEBS J 2023 PubMed ID: 36597763 DOI: 10.1111/febs.16717

20991 Jin X, Tanaka H, Jin M, Fujita K, Homma H, Inotsume M, Yong H, Umeda K, Kodera N, Ando T, Okazawa H. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Nat Commun 2023 14(1):9 PubMed ID: 36599853 DOI: 10.1038/s41467-022-35602-w

21014 Yamada I, Kataoka T, Ikeda R, Tagaya M. Investigation into the Photochemical Properties of Methylene Blue-Immobilized Hydroxyapatite Nanoparticles for Theranostic Application. ACS Appl Bio Mater 2023 PubMed ID: 36648755 DOI: 10.1021/acsabm.2c00756

21065 Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A. Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly. J Am Chem Soc 2023 145(1):135-142 PubMed ID: 36538570 DOI: 10.1021/jacs.2c08974

21072 Onishi K, Ishihara S, Takahashi M, Sakai A, Enomoto A, Suzuki K, Haga H. Substrate stiffness induces nuclear localization of myosin regulatory light chain to suppress apoptosis. FEBS Lett 2023 PubMed ID: 36723402 DOI: 10.1002/1873-3468.14592

21168 Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T. Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer. Stem Cell Res Ther 2023 14(1):40 PubMed ID: 36927781 DOI: 10.1186/s13287-023-03274-y

21332 Ueda H, Tran QTH, Tran LNT, Higasa K, Ikeda Y, Kondo N, Hashiyada M, Sato C, Sato Y, Ashida A, Nishio S, Iwata Y, Iida H, Matsuoka D, Hidaka Y, Fukui K, Itami S, Kawashita N, Sugimoto K, Nozu K, Hattori M, Tsukaguchi H. Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy. Sci Rep 2023 13(1):12003 PubMed ID: 37491439 DOI: 10.1038/s41598-023-38588-7

21366 Takahashi D, Ora T, Sasaki S, Ishii N, Tanaka T, Matsuda T, Ikeda M, Moriyama J, Cho N, Nara H, Maezaki H, Kamaura M, Shimokawa K, Arimoto H. Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem 2023 PubMed ID: 37589438 DOI: 10.1021/acs.jmedchem.3c00861

21373 Suzuki MM, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, Wang X, Kitano Y, Mamiya A, Kibe Y, Nishimura T, Ohka F, Saito R, Sato S, Kobayashi J, Yao R, Miyata K, Kataoka K, Suzuki HI, Kondo Y. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nat Commun 2023 14(1):4521 PubMed ID: 37607907 DOI: 10.1038/s41467-023-40243-8

21485 Zhao X, Ma D, Ishiguro K, Saito H, Akichika S, Matsuzawa I, Mito M, Irie T, Ishibashi K, Wakabayashi K, Sakaguchi Y, Yokoyama T, Mishima Y, Shirouzu M, Iwasaki S, Suzuki T, Suzuki T. Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth. Cell 2023 PubMed ID: 37992713 DOI: 10.1016/j.cell.2023.10.026

21523 Muraoka Y, Muramoto J, Yasuhara Y, Kawatake M, Sakamoto T. Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift. Anal Chem 2023 95(47):17162-17165 PubMed ID: 37955574 DOI: 10.1021/acs.analchem.3c04318

17560 Ueoka R, Sondermann P, Leopold-Messer S, Liu Y, Suo R, Bhushan A, Vadakumchery L, Greczmiel U, Yashiroda Y, Kimura H, Nishimura S, Hoshikawa Y, Yoshida M, Oxenius A, Matsunaga S, Williamson RT, Carreira EM, Piel J. Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium Nat Chem 2022 Nat Chem . 2022 Oct;14(10):1193-1201. PubMed ID: 36064972 DOI: 10.1038/s41557-022-01020-0

17700 Tan A, Xu F, Yokoyama C, Yano S, Konno H. Design, synthesis, and evaluation of the self-assembled antimicrobial peptides based on the ovalbumin-derived peptide TK913 J Pept Sci 2022 28(4):e3375 PubMed ID: 34725889 DOI: 10.1002/psc.3375

17709 Kimura A, Arai T, Ueno M, Oyama K, Yu H, Yamashita S, Otome Y, Taguchi M. Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis Pharmaceutics 2022 14(11):2400 PubMed ID: 36365217 DOI: 10.3390/pharmaceutics14112400

17783 Ohshima T, Yamamoto H, Sakamaki Y, Saito C, Mizushima N. NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy J Cell Biol 2022 221(10):e202203102 PubMed ID: 36066504 DOI: 10.1083/jcb.202203102

17788 Takeuchi Y, Ushimaru K, Kaneda K, Maruyama C, Ito T, Yamanaka K, Ogasawara Y, Katano H, Kato Y, Dairi T, Hamano Y. First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria Commun Biol 2022 5(1):1132 PubMed ID: 36289442 DOI: 10.1038/s42003-022-04110-4

20504 Suzuki M, Iwaki K, Kikuchi M, Fujiwara K, Doi N. Characterization of the membrane penetration-enhancing peptide S19 derived from human syncytin-1 for the intracellular delivery of TAT-fused proteins. Biochem Biophys Res Commun 2022 586:63-67 PubMed ID: 34826702 DOI: 10.1016/j.bbrc.2021.11.065

20518 Kadota A, Moriguchi M, Watanabe T, Sekine Y, Nakamura S, Yasuno T, Ohe T, Mashino T, Fujimuro M. A pyridinium‑type fullerene derivative suppresses primary effusion lymphoma cell viability via the downregulation of the Wnt signaling pathway through the destabilization of β‑catenin. Oncol Rep 2022 47(3) PubMed ID: 35014678 DOI: 10.3892/or.2022.8257

16222 Xiaobo Yin, Takayuki Konishi, Kazuo Horikawa, Ryota Tanaka, Yuki Togo, Takanori Noda, Miho Hosoi, Mie Tsuchida, Tatsuki Kunoh, Shuichi Wada, Toshinobu Nakamura, Eisuke Tsuda, Ryuzo Sasaki, Tamio Mizukami, Makoto Hasegawa Structure and Function of Potential Glycosylation Sites of Dynactin-Associated Protein dynAP Mol Biotechnol 2022 Jan 13 PubMed ID: 35022995 DOI: 10.1007/s12033-021-00435-3

16386 Haraguchi T, Koujin T, Shindo T, Bilir Ş, Osakada H, Nishimura K, Hirano Y, Asakawa H, Mori C, Kobayashi S, Okada Y, Chikashige Y, Fukagawa T, Shibata S, Hiraoka Y. Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase Commun Biol 2022 5(1):78 PubMed ID: 35058555 DOI: 10.1038/s42003-022-03021-8

16391 Sakamoto T, Yu Z, Otani Y. Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells Anal Chem 2022 Mar 2 PubMed ID: 35234461 DOI: 10.1021/acs.analchem.1c04804

16428 Fukushima S, Shimohata T, Inoue Y, Kido J, Uebanso T, Mawatari K, Takahashi A. Recruitment of LC3 by Campylobacter jejuni to Bacterial Invasion Site on Host Cells via the Rac1-Mediated Signaling Pathway Front Cell Infect Microbiol 2022 12:829682 PubMed ID: 35310852 DOI: 10.3389/fcimb.2022.829682

20613 Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M. Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells. Analyst 2022 PubMed ID: 35297918 DOI: 10.1039/d2an00052k

20616 Liu JY, Inoshita T, Shiba-Fukushima K, Yoshida S, Ogata K, Ishihama Y, Imai Y, Hattori N. Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation. Hum Mol Genet 2022 PubMed ID: 35313349 DOI: 10.1093/hmg/ddac064

20645 Oda R, Shou J, Zhong W, Ozeki Y, Yasui M, Nuriya M. Direct visualization of general anesthetic propofol on neurons by stimulated Raman scattering microscopy. iScience 2022 25(3):103936 PubMed ID: 35252821 DOI: 10.1016/j.isci.2022.103936

20659 Chino H, Yamasaki A, Ode KL, Ueda HR, Noda NN, Mizushima N. Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins. EMBO Rep 2022 e54801 PubMed ID: 35417087 DOI: 10.15252/embr.202254801

20669 Nakahata M, Tominaga N, Saito K, Nishiyama K, Tanino Y, Saiki K, Kojima M, Sakai S. A bio-synthetic hybrid hydrogel formed under physiological conditions consisting of mucin and a synthetic polymer carrying boronic acid. Macromol Biosci 2022 e2200055 PubMed ID: 35429097 DOI: 10.1002/mabi.202200055

16520 Nagayama K, Hanzawa T. Cell type-specific orientation and migration responses for a microgrooved surface with shallow grooves Biomed Mater Eng 2022 Feb 14 PubMed ID: 35180105 DOI: 10.3233/BME-211356

20725 Inagaki E, Arai E, Hatou S, Sayano T, Taniguchi H, Negishi K, Kanai Y, Sato Y, Okano H, Tsubota K, Shimmura S. The Anterior Eye Chamber as a Visible Medium for In Vivo Tumorigenicity Tests. Stem Cells Transl Med 2022 PubMed ID: 35666752 DOI: 10.1093/stcltm/szac036

20751 Wada KI, Hosokawa K, Ito Y, Maeda M, Harada Y, Yonemitsu Y. Generation of transmitochondrial cybrids using a microfluidic device. Exp Cell Res 2022 418(1):113233 PubMed ID: 35659971 DOI: 10.1016/j.yexcr.2022.113233

20752 Shindo S, Shioya A, Watanabe M, Sasaki T, Suzuki H, Kumagai T, Hwang GW, Nagata K. Development of an adenovirus-mediated reporter assay system to detect a low concentration of retinoic acid in MCF-7 cells. J Toxicol Sci 2022 47(6):249-255 PubMed ID: 35650141 DOI: 10.2131/jts.47.249

20755 Sonoda K, Bogahawatta S, Katayama A, Ujike S, Kuroki S, Kitagawa N, Hirotsuru K, Suzuki N, Miyata T, Kawaguchi SI, Tsujita T. Prolyl Hydroxylase Domain Protein Inhibitor Not Harboring a 2-Oxoglutarate Scaffold Protects against Hypoxic Stress. ACS Pharmacol Transl Sci 2022 5(5):362-372 PubMed ID: 35592438 DOI: 10.1021/acsptsci.2c00002

16707 Yasuyuki Morita A Technique for Measuring the 3D Deformation of a Multiphase Structure to Elucidate the Mechanism of Tumor Invasion Multidisciplinary Computational Anatomy 2022 139-143 DOI: 10.1007/978-981-16-4325-5_16

16712 Chukai Y, Ito G, Konno M, Sakata Y, Ozaki T. Mitochondrial calpain-5 truncates caspase-4 during endoplasmic reticulum stress Biochem Biophys Res Commun 2022 608:156-162 PubMed ID: 35398613 DOI: 10.1016/j.bbrc.2022.03.156

16720 Yoshiro Tahara, Kenichi Ueyama, Michiaki Matsumoto Glycine-Mediated Paclitaxel Dispersion in a Phospholipid Complex JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 2022 55:225-229 DOI: 10.1252/jcej.21we113

16721 Tatsuno T, Ishigaki Y. Multiple Phosphorylations of SR Protein SRSF3 and Its Binding to m 6 A Reader YTHDC1 in Human Cells Cells 2022 11(9):146 PubMed ID: 35563766 DOI: 10.3390/cells11091461

16732 Zhu Z, Kitano T, Morimatsu M, Tanaka A, Morioka R, Lin X, Orino K, Yoshikawa Y. BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents Int J Mol Sci 2022 23(7):4060 PubMed ID: 35409418 DOI: 10.3390/ijms23074060

20840 Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S. Local anesthetic lidocaine-inducible gene, growth differentiation factor-15 suppresses the growth of cancer cell lines. Sci Rep 2022 12(1):14520 PubMed ID: 36008442 DOI: 10.1038/s41598-022-18572-3

20894 Kubota F, Satrialdi, Takano Y, Maeki M, Tokeshi M, Harashima H, Yamada Y. Fine-tuning the encapsulation of a photosensitizer in nanoparticles reveals the relationship between internal structure and phototherapeutic effects. J Biophotonics 2022 e202200119 PubMed ID: 36054273 DOI: 10.1002/jbio.202200119

20895 Yoneda Y, Yahagi T, Harada K, Okamoto Y, Motai S, Matsuzaki K, Kubo M, Fukuyama Y, Ohsaki A. Anchietins A-E: 30-norfriedelane-type triterpenes from Anchietea pyrifolia. Phytochemistry 2022 203:113388 PubMed ID: 36075316 DOI: 10.1016/j.phytochem.2022.113388

20917 Debnath T, Hattori R, Okamoto S, Shibata T, Santra TS, Nagai M. Automated detection of patterned single-cells within hydrogel using deep learning. Sci Rep 2022 12(1):18343 PubMed ID: 36316380 DOI: 10.1038/s41598-022-22774-0

20927 Nakamura M, Fujiwara K, Doi N. Cytoplasmic delivery of siRNA using human-derived membrane penetration-enhancing peptide. J Nanobiotechnology 2022 20(1):458 PubMed ID: 36303212 DOI: 10.1186/s12951-022-01667-4

20954 Ohe S, Kubota Y, Yamaguchi K, Takagi Y, Nashimoto J, Kozuka-Hata H, Oyama M, Furukawa Y, Takekawa M. ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II. Nat Commun 2022 13(1):7476 PubMed ID: 36463234 DOI: 10.1038/s41467-022-35230-4

20955 Morotomi-Yano K, Hiromoto Y, Higaki T, Yano KI. Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ. Sci Rep 2022 12(1):20627 PubMed ID: 36450898 DOI: 10.1038/s41598-022-24883-2

21166 Ogushi S, Kimura T. The Difference in Zinc Concentrations Required for Induction among Metallothionein Isoforms Can Be Explained by the Different MTF1 Affinities to MREs in Its Promoter. Int J Mol Sci 2022 24(1) PubMed ID: 36613726 DOI: 10.3390/ijms24010283

13251 Saito M. Fluorescent Labeling of Connexin with As Complex and X-Y Coordinate Registration of Target Single Cells Based on a Triangle Standard Chip for the Image Analysis of Gap Junctional Communication. Methods Mol Biol 2021 PubMed ID: 32989705 DOI: 10.1007/7651_2020_330

13328 Kagabu M, Yoshino N, Saito T, Miura Y, Takeshita R, Murakami K, Kawamura H, Baba T, Sugiyama T. The efficacy of a third-generation oncolytic herpes simplex viral therapy for an HPV-related uterine cervical cancer model. Int J Clin Oncol 2021 26(3):591-597. PubMed ID: 33146805 DOI: 10.1007/s10147-020-01823-6

13367 Yamaguchi K, Otomo K, Kozawa Y, Tsutsumi M, Inose T, Hirai K, Sato S, Nemoto T, Uji-I H. Adaptive Optical Two-Photon Microscopy for Surface-Profiled Living Biological Specimens. ACS Omega 2021 PubMed ID: 33458495 DOI: 10.1021/acsomega.0c04888

20001 Fukuchi M, Oyama K, Mizuno H, Miyagawa A, Koumoto K, Fukuhara G. Hydrostatic Pressure-Regulated Cellular Calcium Responses. Langmuir 2021 37(2) 820-826 PubMed ID: 33410684 DOI: 10.1021/acs.langmuir.0c03141

13463 Shota Someya et al Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells iScienc 2021 24 PubMed ID: 33615198 DOI: 10.1016/j.isci.2021.102090

20019 Chau S, Fujii A, Wang Y, Vandebroek A, Goda W, Yasui M, Abe Y. Di-lysine motif-like sequences formed by deleting the C-terminal domain of aquaporin-4 prevent its trafficking to the plasma membrane. Genes Cells 2021 PubMed ID: 33474763 DOI: 10.1111/gtc.12829

20040 Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A. The ubiquinone synthesis pathway is a promising drug target for Chagas disease. PLoS One 2021 16(2):e0243855 PubMed ID: 33539347 DOI: 10.1371/journal.pone.0243855

20048 Liu X, Suyama K, Nose T, Shimohigashi M, Shimohigashi Y. Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding. PLoS One 2021 16(2):e0246583 PubMed ID: 33561155 DOI: 10.1371/journal.pone.0246583

20053 Takafuji S, Mori T, Nishimura N, Yamamoto N, Uemura S, Nozu K, Terui K, Toki T, Ito E, Muramatsu H, Takahashi Y, Matsuo M, Yamamura T, Iijima K. Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19. Pediatr Hematol Oncol 2021 1-16 PubMed ID: 33622161 DOI: 10.1080/08880018.2021.1887984

20078 Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T. Characterization of mitochondrial calpain-5. Biochim Biophys Acta Mol Cell Res 2021 1868(5):118989 PubMed ID: 33607190 DOI: 10.1016/j.bbamcr.2021.118989

20112 Liu X, Matsuyama Y, Shimohigashi M, Shimohigashi Y. ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ. Toxicol Lett 2021 345:24-33 PubMed ID: 33857583 DOI: 10.1016/j.toxlet.2021.04.001

14002 Vong K, Tahara T, Urano S, Nasibullin I, Tsubokura K, Nakao Y, Kurbangalieva A, Onoe H, Watanabe Y, Tanaka K. タイトル Disrupting tumor onset and growth via selective cell tagging (SeCT) therapy Sci Adv 2021 7(17):eabg4038 PubMed ID: 33893089 DOI: 10.1126/sciadv.abg4038

14183 Okawa F, Hama Y, Zhang S, Morishita H, Yamamoto H, Levine TP, Mizushima N. Evolution and insights into the structure and function of the DedA superfamily containing TMEM41B and VMP1 J Cell Sci 2021 134(8):jcs255877 PubMed ID: 33771928 DOI: 10.1242/jcs.255877

20153 Yin X, Yamada S, Kobayashi H, Tanaka R, Togo Y, Hosoi M, Tsuchida M, Kunoh T, Wada S, Nakamura T, Sasaki R, Mizukami T, Hasegawa M. Expression and cell transformation activity of dynactin-associated protein isoforms. FEBS Open Bio 2021 PubMed ID: 34043884 DOI: 10.1002/2211-5463.13202

20156 Oyama TG, Oyama K, Kimura A, Yoshida F, Ishida R, Yamazaki M, Miyoshi H, Taguchi M. Collagen hydrogels with controllable combined cues of elasticity and topography to regulate cellular processes. Biomed Mater 2021 PubMed ID: 34030146 DOI: 10.1088/1748-605X/ac0452

20003 Inaba H, Miao Q, Nakata T. Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling Biol Chem 2021 296:100290 PubMed ID: 33453281 DOI: 10.1016/j.jbc.2021.100290

14869 Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K. miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells Sci Rep 2021 11(1):13502 PubMed ID: 34226586 DOI: 10.1038/s41598-021-92879-5

15011 Sekino Y, Imaizumi A, Komune N, Ono M, Sato K, Masuda S, Fujimura A, Koike K, Hongo T, Uchi R, Onishi H, Nakagawa T. Establishment and characterization of a primary cell culture derived from external auditory canal squamous cell carcinoma FEBS Open Bio 2021 Jun 11 PubMed ID: 34115931 DOI: 10.1002/2211-5463.13225

20253 Yanagi T, Kaminaga K, Suzuki M, Abe H, Yamamoto H, Ohshima T, Kuwahata A, Sekino M, Imaoka T, Kakinuma S, Sugi T, Kada W, Hanaizumi O, Igarashi R. All-Optical Wide-Field Selective Imaging of Fluorescent Nanodiamonds in Cells, In Vivo and Ex Vivo. ACS Nano 2021 PubMed ID: 34339180 DOI: 10.1021/acsnano.0c07740

20290 Kimura A, Ueno M, Arai T, Oyama K, Taguchi M. Radiation Crosslinked Smart Peptide Nanoparticles: A New Platform for Tumor Imaging. Nanomaterials (Basel) 2021 11(3) PubMed ID: 33809100 DOI: 10.3390/nano11030714

20291 Kowada T, Watanabe T, Liu R, Mizukami S. Protocol for synthesis and use of a turn-on fluorescent probe for quantifying labile Zn2+ in the Golgi apparatus in live cells. STAR Protoc 2021 2(2) PubMed ID: 33796872 DOI: 10.1016/j.xpro.2021.100395

20310 Endo-Takahashi Y, Kurokawa R, Sato K, Takizawa N, Katagiri F, Hamano N, Suzuki R, Maruyama K, Nomizu M, Takagi N, Negishi Y. Ternary Complexes of pDNA, Neuron-Binding Peptide, and PEGylated Polyethyleneimine for Brain Delivery with Nano-Bubbles and Ultrasound. Pharmaceutics 2021 13(7): PubMed ID: 34371694 DOI: 10.3390/pharmaceutics13071003

15504 Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y. DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency Nat Commun 2021 12(1):5041 PubMed ID: 34413299 DOI: 10.1038/s41467-021-25249-4

15520 Tomoko Gowa Oyama, Kotaro Oyama, Hiromi Miyoshi, Mitsumasa Taguchi 3D cell sheets formed via cell-driven buckling-delamination of patterned thin films Materials & Design 2021 208:109975 DOI: 10.1016/j.matdes.2021.109975

20364 Fukasawa K, Gotoh M, Uwamizu A, Hirokawa T, Ishikawa M, Shimizu Y, Yamamoto S, Iwasa K, Yoshikawa K, Aoki J, Murakami-Murofushi K. 2-Carba-lysophosphatidic acid is a novel β-lysophosphatidic acid analogue with high potential for lysophosphatidic acid receptor activation and autotaxin inhibition. Sci Rep 2021 11(1):17360 PubMed ID: 34462512 DOI: 10.1038/s41598-021-96931-2

20374 Kato S, Arasaki K, Tokutomi N, Imai Y, Inoshita T, Hattori N, Sasaki T, Sato M, Wakana Y, Inoue H, Tagaya M. Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms. J Cell Sci 2021 PubMed ID: 34704591 DOI: 10.1242/jcs.258699

20402 Yahiro K, Ogura K, Tsutsuki H, Iyoda S, Ohnishi M, Moss J. A novel endoplasmic stress mediator, Kelch domain containing 7B (KLHDC7B), increased Harakiri (HRK) in the SubAB-induced apoptosis signaling pathway. Cell Death Discov 2021 7(1):360 PubMed ID: 34799565 DOI: 10.1038/s41420-021-00753-0

20404 Okada T, Nishida S, Zhang L, Ibrahim Mohamed NN, Wang T, Ijuin T, Kajimoto T, Nakamura SI. Constitutive activation of S1P receptors at the trans-Golgi network is required for surface transport carrier formation. iScience 2021 24(11):103351 PubMed ID: 34805799 DOI: 10.1016/j.isci.2021.103351

20406 Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K. High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines. Heliyon 2021 7(11):e08318 PubMed ID: 34816032 DOI: 10.1016/j.heliyon.2021.e08318

15887 See K, Kadonosono T, Miyamoto K, Tsubaki T, Ota Y, Katsumi M, Ryo S, Aida K, Minegishi M, Isozaki T, Kuchimaru T, Kizaka-Kondoh S. Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display Sci Rep 2021 11(1):22098 PubMed ID: 34764369 DOI: 10.1038/s41598-021-01603-w

20503 Tsuzuki H, Nagatsuka Y, Iwata M, Kitamura N, Nagasawa Y, Matsumoto T, Ito R, Takahashi T, Ito M, Nakamura H, Takei M. Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease. Heliyon 2021 7(11):e08380 PubMed ID: 34825089 DOI: 10.1016/j.heliyon.2021.e08380

16049 Endo A, Asayama S. Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization Pharmaceutics 2021 13(12):2084 PubMed ID: 34959365 DOI: 10.3390/pharmaceutics13122084

16102 Arung ET, Ramadhan R, Khairunnisa B, Amen Y, Matsumoto M, Nagata M, Kusuma IW, Paramita S, Sukemi, Yadi, Tandirogang N, Takemoto N, Syafrizal, Kim YU, Shimizu K. Cytotoxicity effect of honey, bee pollen, and propolis from seven stingless bees in some cancer cell lines Saudi J Biol Sci 2021 ;28(12):7182-7189 PubMed ID: 34867021 DOI: 10.1016/j.sjbs.2021.08.017

16173 Suzuka J, Tsuda M, Wang L, Kohsaka S, Kishida K, Semba S, Sugino H, Aburatani S, Frauenlob M, Kurokawa T, Kojima S, Ueno T, Ohmiya Y, Mano H, Yasuda K, Gong JP, Tanaka S. Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels Nat Biomed Eng 2021 5(8):914-925 PubMed ID: 33782572 DOI: 10.1038/s41551-021-00692-2

16283 Shibata T, Nagano K, Ueyama M, Ninomiya K, Hirose T, Nagai Y, Ishikawa K, Kawai G, Nakatani K. Small molecule targeting r(UGGAA) n disrupts RNA foci and alleviates disease phenotype in Drosophila model Nat Commun 2021 12(1):236 PubMed ID: 33431896 DOI: 10.1038/s41467-020-20487-4

20672 Sugawara K, Watarai H, Ise Y, Yokose H, Morii Y, Yamawaki N, Okada S, Matsunaga S. Structure Elucidation of Calyxoside B, a Bipolar Sphingolipid from a Marine Sponge Cladocroce sp. through the Use of Beckmann Rearrangement. Mar Drugs 2021 19(6) PubMed ID: 34063932 DOI: 10.3390/md19060287

16519 Wen C, Miura T, Voleti V, Yamaguchi K, Tsutsumi M, Yamamoto K, Otomo K, Fujie Y, Teramoto T, Ishihara T, Aoki K, Nemoto T, Hillman EM, Kimura KD. 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images Elife 2021 10:e59187. PubMed ID: 33781383 DOI: 10.7554/eLife.59187

16627 Fayez S, Cacciatore A, Sun S, Kim M, Aké Assi L, Feineis D, Awale S, Bringmann G. Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus Bioorg Med Chem 2021 30:115950 PubMed ID: 33383442 DOI: 10.1016/j.bmc.2020.115950

16698 Kakihana T, Takahashi M, Katsuragi Y, Yamashita SI, Sango J, Kanki T, Onodera O, Fujii M. The optineurin/TIA1 pathway inhibits aberrant stress granule formation and reduces ubiquitinated TDP-43 iScience 2021 24(7):102733 PubMed ID: 34258561 DOI: 10.1016/j.isci.2021.102733

16699 Nakagami A, Mao Q, Gouhier G, Arima H, Kitagishi H. FRET-Based In-Cell Detection of Highly Selective Supramolecular Complexes of meso-Tetraarylporphyrin with Peptide/BODIPY-Modified Per-O-Methyl-β-Cyclodextrins Chembiochem 2021 22(22):3190-3198 PubMed ID: 34467611 DOI: 10.1002/cbic.202100380

16708 Shou J, Oda R, Hu F, Karasawa K, Nuriya M, Yasui M, Shiramizu B, Min W, Ozeki Y. Super-multiplex imaging of cellular dynamics and heterogeneity by integrated stimulated Raman and fluorescence microscopy iScience 2021 24(8):102832 PubMed ID: 34381966 DOI: 10.1016/j.isci.2021.102832

16716 Kazuyuki Todoroki, Mariko Funasaki, Tadahiro Etoh, Keiichi Matsuzaki, Ayumi Ohsaki Two Erythrina alkaloids and three diarylpropanoids from Erythrina velutina Tetrahedron 2021 9:132383 DOI: 10.1016/j.tet.2021.132383

16735 Okada H, Mimura M, Tomita S, Kurita R. Affinity Diversification of a Polymer Probe for Pattern-recognition-based Biosensing Using Chemical Additives Anal Sci 2021 37(5):713-719 PubMed ID: 33518589 DOI: 10.2116/analsci.20SCP23

17031 Nakamoto H, Katanosaka Y, Chijimatsu R, Mori D, Xuan F, Yano F, Omata Y, Maenohara Y, Murahashi Y, Kawaguchi K, Yamagami R, Inui H, Taketomi S, Taniguchi Y, Kanagawa M, Naruse K, Tanaka S, Saito T. Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage Arthritis Rheumatol 2021 73(8):1441-1450 PubMed ID: 33586252 DOI: 10.1002/art.41684

17871 Takuya Kataoka, Sadaki Samitsu, Mitsuhiro Okuda, Daisuke Kawagoe, Motohiro Tagaya Highly Luminescent Hydroxyapatite Nanoparticles Hybridized with Citric Acid for Their Bifunctional Cell-Labeling and Cytostatic Suppression Properties ACS Applied Nano Materials 2020 3:241-256 DOI: 10.1021/acsanm.9b01933

6918 Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol 2020 27(2):186-196 PubMed ID: 31813846 DOI: 10.1016/j.chembiol.2019.11.010

6961 Hamao K, Ono T, Matsushita M, Hosoya H. ZIP kinase phosphorylated and activated by Rho kinase/ROCK contributes to cytokinesis in mammalian cultured cells. Exp Cell Res 2020 386(1):111707 PubMed ID: 31693874 DOI: 10.1016/j.yexcr.2019.111707

9820 Mai T T Nguyen, Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Suresh Awale 1, Nhan T Nguyen Calosides A-F, Cardenolides From Calotropis gigantea and Their Cytotoxic Activity J Nat Prod 2020 83(2):385-391 PubMed ID: 31967821 DOI: 10.1021/acs.jnatprod.9b00875

9937 Ryosuke Koyama, Yui Kano, Kaori Kikushima, Ayaka Mizutani, Yuta Soeda, Kazuki Miura, Takako Hirano, Toshiyuki Nishio, Wataru Hakamata A Novel Golgi Mannosidase Inhibitor: Molecular Design, Synthesis, Enzyme Inhibition, and Inhibition of Spheroid Formation Bioorg Med Chem 2020 28(11):115492 PubMed ID: 32291147 DOI: 10.1016/j.bmc.2020.115492

12067 Wada Y, Kikuchi A, Kaga A, Shimizu N, Ito J, Onuma R, Fujishima F, Totsune E, Sato R, Niihori T, Shirota M, Funayama R, Sato K, Nakazawa T, Nakayama K, Aoki Y, Aiba S, Nakagawa K, Kure S. Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice. PLoS Genet. 2020 PubMed ID: 32101538 DOI: 10.1371/journal.pgen.1008628

12069 Okada S, Fukai Y, Yoshimoto F, Saitoh H. Chemical manipulations to facilitate membrane blebbing and vesicle shedding on the cellular cortex. Biotechnol. Lett. 2020 42(7) PubMed ID: 32112174 DOI: 10.1007/s10529-020-02848-7

12155 Tomoko G. Oyama, Atsushi Kimura, Naotsugu Nagasawa, Kotaro Oyama and Mitsumasa Taguchi Development of Advanced Biodevices Using Quantum Beam Microfabrication Technology Quantum Beam Sci 2020 DOI: 10.3390/qubs4010014

12996 Nagai M, Kato K, Soga S, Santra TS, Shibata T. Scalable Parallel Manipulation of Single Cells Using Micronozzle Array Integrated with Bidirectional Electrokinetic Pumps. Micromachines (Basel) 2020 PubMed ID: 32331468 DOI: 10.3390/mi11040442

13016 Sano M, Yada R, Nomura Y, Kusukawa T, Ando H, Matsumoto K, Wada K, Tanaka T, Ohara H, Aso Y. Microbial Screening Based on the Mizoroki-Heck Reaction Permits Exploration of Hydroxyhexylitaconic-Acid-Producing Fungi in Soils. Microorganisms 2020 PubMed ID: 32365722 DOI: 10.3390/microorganisms8050648

13055 Kojima H, Itoh T. Preparation and Use of Turn-on Fluorescent Probe for Detection and Live Cell Imaging of Vitamin D Receptor as a Target Protein. STAR Protoc 2020 PubMed ID: 33111084 DOI: 10.1016/j.xpro.2020.100036

13075 Ishihara K, Mitera K, Inoue Y, Fukazawa K. Effects of molecular interactions at various polymer brush surfaces on fibronectin adsorption induced cell adhesion. Colloids Surf B Biointerfaces 2020 PubMed ID: 32592945 DOI: 10.1016/j.colsurfb.2020.111205

13096 Nagayama K, Ohata S, Obata S, Sato A. Macroscopic and microscopic analysis of the mechanical properties and adhesion force of cells using a single cell tensile test and atomic force microscopy: Remarkable differences in cell types. J Mech Behav Biomed Mater 2020 PubMed ID: 32957229 DOI: 10.1016/j.jmbbm.2020.103935

13098 Miyano K, Okamoto S, Yamauchi A, Kawai C, Kajikawa M, Kiyohara T, Tamura M, Taura M, Kuribayashi F. The NADPH oxidase NOX4 promotes the directed migration of endothelial cells by stabilizing vascular endothelial growth factor receptor 2 protein. J Biol Chem 2020 PubMed ID: 32616654 DOI: 10.1074/jbc.RA120.014723

13117 Matsuura Y, Noguchi A, Sakai S, Yokota N, Kawahara H. Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster. J Biochem 2020 PubMed ID: 32687160 DOI: 10.1093/jb/mvaa072

13135 Miura K, Onodera C, Takagi M, Koyama R, Hirano T, Nishio T, Hakamata W. Screening, Synthesis, and Evaluation of Novel Isoflavone Derivatives as Inhibitors of Human Golgi β-Galactosidase. Chem Pharm Bull (Tokyo) 2020 PubMed ID: 32741916 DOI: 10.1248/cpb.c20-00194

13140 Fang J, Gao S, Islam R, Teramoto Y, Maeda H. Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients 2020 PubMed ID: 32751371 DOI: 10.3390/nu12082279

13146 Ertunc N, Sato C, Kitajima K. Sialic acid sulfation is induced by the antibiotic treatment in mammalian cells. Biosci Biotechnol Biochem 2020 PubMed ID: 32752946 DOI: 10.1080/09168451.2020.1792763

13217 Yamanaka R, Shindo Y, Hotta K, Hiroi N, Oka K. Cellular thermogenesis compensates environmental temperature fluctuations for maintaining intracellular temperature. Biochem Biophys Res Commun 2020 PubMed ID: 32928506 DOI: 10.1016/j.bbrc.2020.08.110

13265 Ono T, Terada F, Okumura M, Chihara T, Hamao K. Impairment of cytokinesis by cancer-associated DAPK3 mutations. Biochem Biophys Res Commun 2020 PubMed ID: 33032825 DOI: 10.1016/j.bbrc.2020.09.078

13290 Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H. Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential. Sci Rep 2020 PubMed ID: 33060804 DOI: 10.1038/s41598-020-74590-z

13307 Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y. CELF2 regulates the species-specific alternative splicing of TREM2. Sci Rep 2020 PubMed ID: 33093587 DOI: 10.1038/s41598-020-75057-x

13312 Kuwahara Y, Iehara T, Ichise E, Katsumi Y, Ouchi K, Tsuchiya K, Miyachi M, Konishi E, Sasajima H, Nakamura S, Fumino S, Tajiri T, Johann PD, FrÜhwald MC, Yoshida T, Okuda T, Hosoi H. Novel Two MRT Cell Lines Established from Multiple Sites of a Synchronous MRT Patient. Anticancer Res 2020 PubMed ID: 33109553 DOI: 10.21873/anticanres.14636

13324 Yahiro K, Ogura K, Goto Y, Iyoda S, Kobayashi T, Takeuchi H, Ohnishi M, Moss J. Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival. Sci Rep 2020 PubMed ID: 33144618 DOI: 10.1038/s41598-020-76027-z

13342 Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N. Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity. Nanomaterials (Basel) 2020 PubMed ID: 33202926 DOI: 10.3390/nano10112250

13363 Yokosawa T, Sato A, Wakasugi K. Tryptophan Depletion Modulates Tryptophanyl-tRNA Synthetase-Mediated High-Affinity Tryptophan Uptake into Human Cells. Genes (Basel) 2020 PubMed ID: 33261077 DOI: 10.3390/genes11121423

13372 Nuryadi H, Sumimoto S, Teruya T, Suenaga K, Suda S. Characterization of Macroscopic Colony-Forming Filamentous Cyanobacteria from Okinawan Coasts as Potential Sources of Bioactive Compounds. Mar Biotechnol (NY) 2020 PubMed ID: 33244658 DOI: 10.1007/s10126-020-10010-7

13424 Hiroaki Kitagishi, Misa Jiromaru, and Naomi Hasegawa Intracellular Delivery of Adamantane-Tagged Small Molecule, Proteins, and Liposomes Using an Octaarginine-Conjugated β-Cyclodextrin ACS Appl. Bio Mater. 2020 PubMed ID: 35021734 DOI: 10.1021/acsabm.0c00421

13445 Rahman Md Moshikur, Md. KorbanAli, Rie Wakabayashi, Muhammad Moniruzzaman, Masahiro Goto Formation and potential application of micelles composed of biocompatible N-lauroyl-amino acid ionic liquids surfactant Journal of Molecular Liquids 2020 DOI: 10.1016/j.molliq.2020.114424

13498 Ueno M, Matsunaga A, Teratake Y, Ishizaka Y. Retrotransposition and senescence in mouse heart tissue by viral protein R of human immunodeficiency virus-1 Exp Mol Pathol 2020 114:104433 PubMed ID: 32243892 DOI: 10.1016/j.yexmp.2020.104433

13577 Shimada K, Kobayashi N, Oka N, Takahashi M, Kondo K. Cooperative activation of the human herpesvirus 6B U79/80 early gene promoter by immediate-early proteins IE1B and IE2B Microbiol Immunol 2020 64(11):747-761 PubMed ID: 32910457 DOI: 10.1111/1348-0421.12844

13578 Tan A, Suzuki R, Yokoyama C, Yano S, Konno H. Antimicrobial activity and secondary structure of a novel peptide derived from ovalbumin J Pept Sci 2020 26(10):e3276 PubMed ID: 32715598 DOI: 10.1002/psc.3276

13846 Miura K, Aoyama Y, Natsu Y, Koyama R, Hirano T, Nishio T, Hakamata W. Development of Specific Fluorogenic Substrates for Human β-N-Acetyl-D-hexosaminidase A for Cell-Based Assays Chem Pharm Bull (Tokyo) 2020 68(6):526-53 PubMed ID: 32475856 DOI: 10.1248/cpb.c20-00069

14874 Chee Kei Kong, Yen Nee Tan, Fook Yee Chye, Nam Weng Sit Nutritional composition and biological activities of the edible shoots of Bambusa vulgaris and Gigantochloa ligulata Food Bioscience 2020 36:100650 DOI: 10.1016/j.fbio.2020.100650

16416 Sugai H, Tomita S, Ishihara S, Yoshioka K, Kurita R. Microfluidic Sensing System with a Multichannel Surface Plasmon Resonance Chip: Damage-Free Characterization of Cells by Pattern Recognition Anal Chem 2020 92(22):14939-14946 PubMed ID: 33112611 DOI: 10.1021/acs.analchem.0c02220

16623 Wakabayashi K, Sakurai F, Ono R, Fujiwara T, Mizuguchi H. Development of a Novel Oncolytic Adenovirus Expressing a Short-hairpin RNA Against Cullin 4A Anticancer Res 2020 40(1):161-168 PubMed ID: 31892564 DOI: 10.21873/anticanres.13937

16625 Fayez S, Bruhn T, Feineis D, Assi LA, Awale S, Bringmann G. Ancistrosecolines A-F, Unprecedented seco-Naphthylisoquinoline Alkaloids from the Roots of Ancistrocladus abbreviatus, with Apoptosis-Inducing Potential against HeLa Cancer Cells J Nat Prod 2020 83(4):1139-1151 PubMed ID: 32125158 DOI: 10.1021/acs.jnatprod.9b01168

16820 CK Kong, YN Tan, FY Chy, NW Sit Nutritional compositions, biological activities, and phytochemical contents of the edible bamboo shoot, Dendrocalamus asper, from Malaysia Food Research Journal 2020 27(3):546-556

16821 Ishihara K, Ito M, Fukazawa K, Inoue Y. Interface of Phospholipid Polymer Grafting Layers to Analyze Functions of Immobilized Oligopeptides Involved in Cell Adhesion ACS Biomater Sci Eng 2020 6(7):3984-3993 PubMed ID: 33463330 DOI: 10.1021/acsbiomaterials.0c00518

17866 Ahmed Ashour, Yhiya Amen, Ahmed E. Allam, Takashi Kudo, Maki Nagata, Koichiro Ohnuki, Kuniyoshi Shimizu New isoindolinones from the fruiting bodies of the fungus Hericium erinaceus Phytochemistry Letters 2019 32:10-14 DOI: 10.1016/j.phytol.2019.04.017

11444 Mitsuhashi H, Homma S, Beermann ML, Ishimaru S, Takeda H, Yu BK, Liu K, Duraiswamy S, Boyce FM, Miller JB. Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Sci Rep 2019 PubMed ID: 30783185 DOI: 10.1038/s41598-018-36684-7

11492 Bannai H, Hirose M, Niwa F, Mikoshiba K. Dissection of Local Ca2+ Signals in Cultured Cells by Membrane-targeted Ca2+ Indicators. J Vis Exp 2019 PubMed ID: 30958464 DOI: 10.3791/59246

5357 Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell 2019 76(5):797-810 PubMed ID: 31606272 DOI: 10.1016/j.molcel.2019.09.009

11625 Kurosawa N, Wakata Y, Ida K, Midorikawa A, Isobe M. High throughput development of TCR-mimic antibody that targets survivin-2B80-88/HLA-A*A24 and its application in a bispecific T-cell engager. Sci Rep 2019 PubMed ID: 31285464 DOI: 10.1038/s41598-019-46198-5

11675 Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging CHEMNANOMAT 2019 DOI: 10.1002/cnma.201900289

11756 Hirano K, Fujimaki M, Sasazawa Y, Yamaguchi A, Ishikawa KI, Miyamoto K, Souma S, Furuya N, Imamichi Y, Yamada D, Saya H, Akamatsu W, Saiki S, Hattori N. Neuroprotective effects of memantine via enhancement of autophagy. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 31431260 DOI: 10.1016/j.bbrc.2019.08.025

11805 Kikuchi S, Noguchi K, Wakai K, Hamazaki Y, Tozawa K, Jomori T, Sasako M, Miwa H. Propagermanium Induces NK Cell Maturation and Tends to Prolong Overall Survival of Patients With Refractory Cancer. Anticancer Res. 2019 PubMed ID: 31519568 DOI: 10.21873/anticanres.13651

4508 Kawai T, Ota N, Okada K, Imasato A, Owa Y, Morita M, Tada M, Tanaka Y. Ultrasensitive Single Cell Metabolomics by Capillary Electrophoresis-Mass Spectrometry with a Thin-Walled Tapered Emitter and Large-Volume Dual Sample Preconcentration. Anal Chem 2019 91(16):10564-10572 PubMed ID: 31357863 DOI: 10.1021/acs.analchem.9b01578

6914 Matsuura R, Inabe K, Otsuki H, Kurokawa K, Dohmae N, Aida Y. Three YXXL Sequences of a Bovine Leukemia Virus Transmembrane Protein are Independently Required for Fusion Activity by Controlling Expression on the Cell Membrane. Viruses 2019 11(12):1140 PubMed ID: 31835517 DOI: 10.3390/v11121140

9728 Sayaka Akieda-Asai, Hao Ma, Yukari Date Palmitic Acid Induces Guanylin Gene Expression Through the Toll-like Receptor 4/nuclear factor-κB Pathway in Rat Macrophages Am J Physiol Cell Physiol 2019 317(6):C1239-C1246 PubMed ID: 31553648 DOI: 10.1152/ajpcell.00081.2019

9939 Kazuki Miura, Takumi Tsukagoshi, Takako Hirano, Toshiyuki Nishio, Wataru Hakamata Development of Fluorogenic Substrates of α-l-Fucosidase Useful for Inhibitor Screening and Gene-expression Profiling ACS Med Chem Lett 2019 10(9):1309-1313 PubMed ID: 31531202 DOI: 10.1021/acsmedchemlett.9b00259

10594 Safrina Dyah Hardiningtyas, Rie Wakabayashi, Ryutaro Ishiyama, Yuki Owada, Masahiro Goto, Noriho Kamiya Enhanced Potential of Therapeutic Applications of Curcumin Using Solid-in-Water Nanodispersion Technique JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 2019 5:138-143 DOI: 10.1252/jcej.18we060

10597 Rahman Md.Moshikura Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Muhammad Moniruzzaman, Masahiro Goto Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation Journal of Molecular Liquids 2019 278:226-233 DOI: 10.1016/j.molliq.2019.01.063

12286 Nilufar Rahimova, Hasan Babazada, Yuriko Higuchi, Fumiyoshi Yamashita, Mitsuru Hashida Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells Biochim Biophys Acta Mol Cell Res 2019 1866(2):190-198 PubMed ID: 30391277 DOI: 10.1016/j.bbamcr.2018.10.018

12380 Chinnathambi S, Hanagata N. Photostability of quantum dot micelles under ultraviolet irradiation Luminescence 2019 34(5):472-479 PubMed ID: 30809921 DOI: 10.1002/bio.3618

12430 Moriguchi M, Watanabe T, Fujimuro M. Capsaicin Induces ATF4 Translation with Upregulation of CHOP, GADD34 and PUMA Biol Pharm Bull 2019 42(8):1428-1432 PubMed ID: 31366879 DOI: 10.1248/bpb.b19-00303

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12433 Khanmohammadi M, Sakai S, Taya M. Characterization of encapsulated cells within hyaluronic acid and alginate microcapsules produced via horseradish peroxidase-catalyzed crosslinking J Biomater Sci Polym Ed 2019 30(4):295-307 PubMed ID: 30593259 DOI: 10.1080/09205063.2018.1562637

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4207 Takahashi T, Mine Y, Okamoto T. 2,3-Dimethoxy-5-methyl-p-benzoquinone (Coenzyme Q0) Disrupts Carbohydrate Metabolism of HeLa Cells by Adduct Formation with Intracellular Free Sulfhydryl-Groups, and Induces ATP Depletion and Necrosis. Biol. Pharm. Bull. 2018 PubMed ID: 30504682 DOI: 10.1248/bpb.b18-00497

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4210 Ichimizu S, Watanabe H, Maeda H, Hamasaki K, Nakamura Y, Chuang VTG, Kinoshita R, Nishida K, Tanaka R, Enoki Y, Ishima Y, Kuniyasu A, Kobashigawa Y, Morioka H, Futaki S, Otagiri M, Maruyama T. Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery. J Control Release 2018 PubMed ID: 29530390 DOI: 10.1016/j.jconrel.2018.02.037

4478 Omachi K, Kamura M, Teramoto K, Kojima H, Yokota T, Kaseda S, Kuwazuru J, Fukuda R, Koyama K, Matsuyama S, Motomura K, Shuto T, Suico MA, Kai H. A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome. Cell Chem Biol 2018 25(5):634-643.e4 PubMed ID: 29526710 DOI: 10.1016/j.chembiol.2018.02.003

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4480 Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, Tagaya M. Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3. J. Lipid Res. 2018 59(5):805-819 PubMed ID: 29549094 DOI: 10.1194/jlr.M081679

4481 Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Reto Brun, Suresh Awale and Gerhard Bringmann Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells RSC Adv 2018 8:5243 PubMed ID: 35542436 DOI: 10.1039/c8ra00363g

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9940 Ryosuke Koyama, Wataru Hakamata, Takako Hirano, Toshiyuki Nishio Identification of Small-Molecule Inhibitors of Human Golgi Mannosidase via a Drug Repositioning Screen Chem Pharm Bull (Tokyo) 2018 66(6):678-681 PubMed ID: 29540634 DOI: 10.1248/cpb.c17-01009

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10628 Goto M, Osada S, Imagawa M, Nishizuka M. FAD104, a regulator of adipogenesis, is a novel suppressor of TGF-β-mediated EMT in cervical cancer cells. Sci Rep 2017 7:16365 PubMed ID: 29180690 DOI: 10.1038/s41598-017-16555-3

10637 Yamamura T, Nozu K, Miyoshi Y, Nakanishi K, Fujimura J, Horinouchi T, Minamikawa S, Mori N, Fujimaru R, Nakanishi K, Ninchoji T, Kaito H, Mariko TI, Morioka I, Matsuo M, Iijima K. An in vitro splicing assay reveals the pathogenicity of a novel intronic variant in ATP6V0A4 for autosomal recessive distal renal tubular acidosis. BMC Nephrol 2017 18:353 PubMed ID: 29202719 DOI: 10.1186/s12882-017-0774-4

10924 Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin RSC Adv 2017 7, 2392-2402 DOI: 10.1039/C6RA26592H

10945 Development of a Cartridge-type Cell Culture Device Combined with Poly(N-isopropylacrylamide) Coated Substrates IEEJ Transactions on Sensors and Micromachines 2017 137, 78-83 DOI: 10.1541/ieejsmas.137.78

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4530 Yuki Hiruta, ORCID logo, Yuki Kanda, Naoya Katsuyama and Hideko Kanazawa Dual temperature- and pH-responsive polymeric micelle for selective and efficient two-step doxorubicin delivery RSC Adv. 2017 7, 29540-29549 DOI: 10.1039/C7RA03579A

4546 Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M. Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17. Nat Commun 2017 8:15406 PubMed ID: 28504273 DOI: 10.1038/ncomms15406

12208 Yuki Hiruta, Ryo Nemoto, Hideko Kanazawa Design and synthesis of temperature-responsive polymer/silica hybrid nanoparticles and application to thermally controlled cellular uptake Colloids Surf B Biointerfaces 2017 153:2-9 PubMed ID: 28192714 DOI: 10.1016/j.colsurfb.2017.01.052

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14611 Ueda T, Tsubamoto H, Inoue K, Sakata K, Shibahara H, Sonoda T. Itraconazole Modulates Hedgehog, WNT/β-catenin, as well as Akt Signalling, and Inhibits Proliferation of Cervical Cancer Cells Anticancer Res 2017 3521-3526 PubMed ID: 28668841 DOI: 10.21873/anticanres.11720

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14661 Naotsugu Nagasawa, Atsushi Kimura, Akira Idesaki, Naoto Yamada, Masashi Koka, Takahiro Satoh, Yasuyuki Ishii, Mitsumasa Taguchi Microfabrication of biocompatible hydrogels by proton beam writing Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 2017 409:102-106 DOI: 10.1016/j.nimb.2017.04.043

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14725 Minegishi S, Yumura A, Miyoshi H, Negi S, Taketani S, Motterlini R, Foresti R, Kano K, Kitagishi H. Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model Complexes J Am Chem Soc 2017 139(16):5984-5991 PubMed ID: 28388069 DOI: 10.1021/jacs.7b02229

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14769 Motohiro Tagaya, Shigeaki Abe, Satoshi Motozuka, Kota Shiba, Taro Takemura, Ikuo Hayashi, Yoshimitsu Sakaguchi Surface-engineered mesoporous silica particles with luminescent, cytocompatible and targeting properties for cancer cell imaging RSC Advances 2017 7:13643-13652 DOI: 10.1039/c7ra00535k

16616 Machitani M, Sakurai F, Wakabayashi K, Tachibana M, Fujiwara T, Mizuguchi H. Enhanced Oncolytic Activities of the Telomerase-Specific Replication-Competent Adenovirus Expressing Short-Hairpin RNA against Dicer Mol Cancer Ther 2017 16(1):251-259 PubMed ID: 27760834 DOI: 10.1158/1535-7163.MCT-16-0383

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6612 Okuma T, Hirata M, Yano F, Mori D, Kawaguchi H, Chung UI, Tanaka S, Saito T. Regulation of mouse chondrocyte differentiation by CCAAT/enhancer-binding proteins. Biomed Res 2015 36(1):21-9 PubMed ID: 25749148 DOI: 10.2220/biomedres.36.21

9955 Wataru Hakamata, Kazuki Miura, Takako Hirano, Toshiyuki Nishio Identification of a Novel Glycan Processing Enzyme With Exo-Acting β-Allosidase Activity in the Golgi Apparatus Using a New Platform for the Synthesis of Fluorescent Substrates Bioorg Med Chem 2015 23(1):73-9 PubMed ID: 25497961 DOI: 10.1016/j.bmc.2014.11.023

12243 Takuma Nozoe, Shigemi Goda, Roman Selyanchyn, Tao Wang, Kohji Nakazawa, Takeshi Hirano, Hidetaka Matsui, Seung-Woo Lee In vitro detection of small molecule metabolites excreted from cancer cells using a Tenax TA thin-film microextraction device J Chromatogr B Analyt Technol Biomed Life Sci 2015 991:99-107. PubMed ID: 25932789 DOI: 10.1016/j.jchromb.2015.04.016

12244 Shigeru Negi, Yuka Terada, Misato Suzuyama, Haruka Matsumoto, Akino Honbo, Yoko Amagase, Yumiko Mizukawa, Akiko Kiriyama, Katsumi Iga, Tetsuro Urushidaini, Yukio Sugiura Intrinsic cell permeability of the GAGA zinc finger protein into HeLa cells Biochem Biophys Res Commun 2015 464(4):1034-1039 PubMed ID: 26187668 DOI: 10.1016/j.bbrc.2015.07.060

12253 Kazuaki Nagayama, Yumi Hamaji, Yuji Sato, Takeo Matsumoto Mechanical trapping of the nucleus on micropillared surfaces inhibits the proliferation of vascular smooth muscle cells but not cervical cancer HeLa cells J Biomech 2015 48(10):1796-803 PubMed ID: 26054426 DOI: 10.1016/j.jbiomech.2015.05.004

12254 Keisuke Niikura, Kenichi Horisawa, Nobuhide Doi A fusogenic peptide from a sea urchin fertilization protein promotes intracellular delivery of biomacromolecules by facilitating endosomal escape J Control Release 2015 212:85-93 PubMed ID: 26091921 DOI: 10.1016/j.jconrel.2015.06.020

14968 Ishigaki Y, Nakamura Y, Tatsuno T, Ma S, Tomosugi N. Phosphorylation status of human RNA-binding protein 8A in cells and its inhibitory regulation by Magoh Exp Biol Med (Maywood) 2015 240(4):438-45 PubMed ID: 25349214 DOI: 10.1177/1535370214556945

14982 Miyagawa-Yamaguchi A, Kotani N, Honke K. Each GPI-anchored protein species forms a specific lipid raft depending on its GPI attachment signa Glycoconj J 2015 32(7):531-40 PubMed ID: 25948169 DOI: 10.1007/s10719-015-9595-5

14999 Kondo T, Okada M, Kunihiro K, Takahashi M, Yaoita Y, Hosoya H, Hamao K. Characterization of myosin II regulatory light chain isoforms in HeLa cells Cytoskeleton (Hoboken) 2015 72(12):609-20 PubMed ID: 26663899 DOI: 10.1002/cm.21268

15132 Iwamoto Y, Kodera M, Hitomi Y. Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex Chem Commun (Camb) 2015 51(46):9539-42 PubMed ID: 25967395 DOI: 10.1039/c5cc02566d

15160 Yuki Hiruta, Takaaki Funatsu, Minami Matsuura, Jian Wang, Eri Ayano, Hideko Kanazawa pH/temperature-responsive fluorescence polymer probe with pH-controlled cellular uptake Sensors and Actuators B: Chemical 2015 207:724-731 DOI: 10.1016/j.snb.2014.10.065

15194 Ahmed F. M. El-Mahdy, Takayuki Shibata, Tsutomu Kabashima, Qinchang Zhu, Masaaki Kai Delivery of siRNA using siRNA/cationic vector complexes encapsulated in dendrimer-like polymeric DNAs RSC Advances 2015 5:32775-32785 DOI: 10.1039/c5ra01032b

15209 Kasai A, Arafuka S, Koshiba N, Takahashi D, Toshima K. Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells Org Biomol Chem 2015 13(42):10556-68 PubMed ID: 26340595 DOI: 10.1039/c5ob01634g

15239 Wakimoto T, Uchida K, Mimura K, Kanagawa T, Mehandjiev TR, Aoshima H, Kokubo K, Mitsuda N, Yoshioka Y, Tsutsumi Y, Kimura T, Yanagihara I. Hydroxylated fullerene: a potential antiinflammatory and antioxidant agent for preventing mouse preterm birth Am J Obstet Gynecol 2015 213(5):708.e1-9 PubMed ID: 26196453 DOI: 10.1016/j.ajog.2015.07.017

6814 Liew YJ, Soh WT, Jiemy WF, Hwang JS. Mutagenesis and functional analysis of the pore-forming toxin HALT-1 from Hydra magnipapillata Toxins (Basel) 2015 7(2):407-22 PubMed ID: 25654788 DOI: 10.3390/toxins7020407

13624 Tamura M, Yanagawa F, Sugiura S, Takagi T, Sumaru K, Kanamori T. Click-crosslinkable and photodegradable gelatin hydrogels for cytocompatible optical cell manipulation in natural environment Sci Rep 2015 5:15060 PubMed ID: 26450015 DOI: 10.1038/srep15060

17465 Kitai Y, Hayashi K, Otsuka M, Nishiwaki H, Senoo T, Ishii T, Sakane G, Sugiura M, Tamura H. New Sesquiterpene Lactone Dimer, Uvedafolin, Extracted from Eight Yacon Leaf Varieties (Smallanthus sonchifolius): Cytotoxicity in HeLa, HL-60, and Murine B16-F10 Melanoma Cell Lines J Agric Food Chem 2015 63(50):10856-61 PubMed ID: 26576855 DOI: 10.1021/acs.jafc.5b05229

4056 Xu B, Ju Y, Cui Y, Song G, Iwase Y, Hosoi A, Morita Y. tLyP-1-conjugated Au-nanorod@SiO(2) core-shell nanoparticles for tumor-targeted drug delivery and photothermal therapy. Langmuir 2014 30:7789-97 PubMed ID: 24921672 DOI: 10.1021/la500595b

5643 Ishikawa K, Ishikawa A, Shoji Y, Imai T. A genotoxic stress-responsive miRNA, miR-574-3p, delays cell growth by suppressing the enhancer of rudimentary homolog gene in vitro. Int J Mol Sci 2014 15(2):2971-90 PubMed ID: 24566139 DOI: 10.3390/ijms15022971

6331 Miura Y, Sato T, Sakurai Y, Sakai R, Hiraoka W, Endo T. Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells. Biol Pharm Bull 2014 37(8):1308-14 PubMed ID: 25087952 DOI: 10.1248/bpb.b14-00170

9979 Wataru Hakamata, Saori Tamura, Takako Hirano, Toshiyuki Nishio Multicolor Imaging of Endoplasmic Reticulum-Located Esterase as a Prodrug Activation Enzyme ACS Med Chem Lett . 2014 5(4):321-5 PubMed ID: 24900834 DOI: 10.1021/ml400398t

15861 Junedi S, Yasuhara K, Nagao S, Kikuchi J, Hirota S. Morphological change of cell membrane by interaction with domain-swapped cytochrome c oligomers Chembiochem 2014 15(4):517-21 PubMed ID: 24449526 DOI: 10.1002/cbic.201300728

15862 Kuroda A, Ishigaki Y, Nilsson M, Sato K, Sato K. Microfluidics-based in situ padlock/rolling circle amplification system for counting single DNA molecules in a cell Anal Sci 2014 30(12):1107-12 PubMed ID: 25492458 DOI: 10.2116/analsci.30.1107

15865 Yutaka Hitomi, Toshiyuki Takeyasu, Masahito Kodera Development of Green-Emitting Iron Complex-Based Fluorescent Probes for Intracellular Hydrogen Peroxide Imaging Bulletin of the Chemical Society of Japan 2014 87:819-824 DOI: 10.1246/bcsj.20140055

15900 Hirofumi Shintaku, Kazumi Hakamada, Hiroshi Fujimoto, Takeshi Nagata, Jun Miyake, Satoyuki Kawano Measurement of local electric field in microdevices for low-voltage electroporation of adherent cells Microsystem Technologies 2014 20:303-313 DOI: 10.1007/s00542-013-1797-9

15901 Kadonosono T, Yabe E, Furuta T, Yamano A, Tsubaki T, Sekine T, Kuchimaru T, Sakurai M, Kizaka-Kondoh S. A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides PLoS One 2014 ;9(8):e103397. PubMed ID: 25084350 DOI: 10.1371/journal.pone.0103397

17091 Daisuke Nishikiori, Yuichi Miyamoto Enhancement of the Cytotoxic Effects of Bleomycin with Permeabilization of the Plasma Membrane by Photofrin®-Mediated Photodynamic Therapy In Vitro IFMBE Proceedings 2014 711-713 DOI: 10.1007/978-3-319-02913-9_181

3914 Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai Cancer cells uptake porphyrins via heme carrier protein 1 Journal of Porphyrins and Phthalocyanines 2013 17:36-43 DOI: 10.1142/S1088424612501192

6565 Yano F, Saito T, Ogata N, Yamazawa T, Iino M, Chung UI, Kawaguchi H. β-catenin regulates parathyroid hormone/parathyroid hormone-related protein receptor signals and chondrocyte hypertrophy through binding to the intracellular C-terminal region of the receptor. Arthritis Rheum 2013 65(2):429-35 PubMed ID: 23124878 DOI: 10.1002/art.37779

12863 Tsuji T, Yoshitomi H, Usukura J. Endocytic mechanism of transferrin-conjugated nanoparticles and the effects of their size and ligand number on the efficiency of drug delivery Microscopy (Oxf) 2013 62(3):341-52 PubMed ID: 23204307 DOI: 10.1093/jmicro/dfs080

15769 Tanaka T, Okada M, Hozumi Y, Tachibana K, Kitanaka C, Hamamoto Y, Martelli AM, Topham MK, Iino M, Goto K. Cytoplasmic localization of DGKζ exerts a protective effect against p53-mediated cytotoxicity J Cell Sci 2013 126(Pt 13):2785-97 PubMed ID: 23606744 DOI: 10.1242/jcs.118711

15786 Ono T, Yamashita D, Hirano T. Condensin II initiates sister chromatid resolution during S phase J Cell Biol 2013 200(4):429-41 PubMed ID: 23401001 DOI: 10.1083/jcb.201208008

15788 Kajimoto T, Okada T, Miya S, Zhang L, Nakamura S. Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes Nat Commun 2013 4:2712 PubMed ID: 24231649 DOI: 10.1038/ncomms3712

15922 Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y. Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers Proc Natl Acad Sci U S A 2013 110(6):2105-10 PubMed ID: 23345451 DOI: 10.1073/pnas.1214233110

15938 Himeda T, Hosomi T, Okuwa T, Muraki Y, Ohara Y. Saffold virus type 3 (SAFV-3) persists in HeLa cells PLoS One 2013 e53194 PubMed ID: 23308162 DOI: 10.1371/journal.pone.0053194

15939 Uchida K, Nakahira K, Mimura K, Shimizu T, De Seta F, Wakimoto T, Kawai Y, Nomiyama M, Kuwano K, Guaschino S, Yanagihara I. Effects of Ureaplasma parvum lipoprotein multiple-banded antigen on pregnancy outcome in mice J Reprod Immunol 2013 100(2):118-27 PubMed ID: 24238827 DOI: 10.1016/j.jri.2013.10.001

15943 Tsuyoshi KIMURA, Yukie KANDA, Asami SANO, Kwangwoo NAM, Yoshihiro SASAKI, Kazunari AKIYOSHI, Toshiya FUJISATO, Akio KISHIDA High Hydrostatic Pressurized Lipoplex Enhances Transfection Efficiency In Vitro Advanced Biomedical Engineering 2013 2:80-83 DOI: 10.14326/abe.2.80

15945 Ayaki Miyama, Masumi Yamada, Sari Sugaya, Minoru Seki A droplet-based microfluidic process to produce yarn-ball-shaped hydrogel microbeads RSC Advances 2013 3:12299 DOI: 10.1039/c3ra41747f

15971 Satoshi Fujita, Reiko Onuki-Nagasaki, Junji Fukuda, Junko Enomoto, Suichi Yamaguchi, Masato Miyake Development of super-dense transfected cell microarrays generated by piezoelectric inkjet printing Lab Chip 2013 13:77-80 PubMed ID: 23165644 DOI: 10.1039/c2lc40709d

7614 Kondo T, Isoda R, Uchimura T, Sugiyama M, Hamao K, Hosoya H. Diphosphorylated but not monophosphorylated myosin II regulatory light chain localizes to the midzone without its heavy chain during cytokinesis. Biochem. Biophys. Res. Commun. 2012 417:686-91 PubMed ID: 22166199 DOI: 10.1016/j.bbrc.2011.11.151

7617 Satow R, Shitashige M, Jigami T, Fukami K, Honda K, Kitabayashi I, Yamada T. β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells. Gastroenterology 2012 142:572-81 PubMed ID: 22155184 DOI: 10.1053/j.gastro.2011.11.041

7662 Byambaa B, Konno T, Ishihara K. Cell adhesion control on photoreactive phospholipid polymer surfaces. Colloids Surf B Biointerfaces 2012 99:1-6 PubMed ID: 21982212 DOI: 10.1016/j.colsurfb.2011.08.029

6096 Sakamoto K, Fujii T, Kawachi H, Miki Y, Omura K, Morita K, Kayamori K, Katsube K, Yamaguchi A. Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 2012 92(5):688-702 PubMed ID: 22330335 DOI: 10.1038/labinvest.2012.9

6318 Miura Y, Sakurai Y, Endo T. O-GlcNAc modification affects the ATM-mediated DNA damage response. Biochim Biophys Acta 2012 1820(10):1678-85 PubMed ID: 22759405 DOI: 10.1016/j.bbagen.2012.06.013

6433 Hiratochi M, Tatani K, Shimizu K, Kuramochi Y, Kikuchi N, Kamada N, Itoh F, Isaji M. Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides. Eur J Pharmacol 2012 690(1-3):183-91 PubMed ID: 22709993 DOI: 10.1016/j.ejphar.2012.06.015

9161 Takahiro Seki, Ken-ich Yoshino, Shigeru Tanaka, Eisuke Dohi, Tomoya Onji, Kazuhiro Yamamoto, Izumi Hide, Henry L Paulson, Naoaki Saito, Norio Sakai Establishment of a Novel Fluorescence-Based Method to Evaluate Chaperone-Mediated Autophagy in a Single Neuron PLoS One 2012 7 (2), e31232 PubMed ID: 22363588 DOI: 10.1371/journal.pone.0031232

14005 Sato Y, Hatakeyama H, Sakurai Y, Hyodo M, Akita H, Harashima H. A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo J Control Release 2012 163(3):267-76 PubMed ID: 23000694 DOI: 10.1016/j.jconrel.2012.09.009

15735 Kondo T, Itakura S, Hamao K, Hosoya H. Phosphorylation of myosin II regulatory light chain controls its accumulation, not that of actin, at the contractile ring in HeLa cells Exp Cell Res 2012 318(8):915-24 PubMed ID: 22374324 DOI: 10.1016/j.yexcr.2012.02.009

15738 Kawai S, Amano A. BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex J Cell Biol 2012 197(2):201-8 PubMed ID: 22492723 DOI: 10.1083/jcb.201110008

15748 Sugimoto M, Watanabe T, Sugimoto Y. The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins PLoS One 2012 7(7):e41267 PubMed ID: 22815983 DOI: 10.1371/journal.pone.0041267

15750 Tatsuya Nishihara, Hiroshi Nonaka, Tatsuya Naganuma, Kazuhiro Ichikawa, Shinsuke Sando Mouse lactate dehydrogenase X: A promising magnetic resonance reporter protein using hyperpolarized pyruvic acid derivative Y Chem. Sci 2012 3:800-806 DOI: 10.1039/c1sc00919b

15757 Niwa F, Bannai H, Arizono M, Fukatsu K, Triller A, Mikoshiba K. Gephyrin-independent GABA(A)R mobility and clustering during plasticity PLoS One 2012 7(4):e36148 PubMed ID: 22563445 DOI: 10.1371/journal.pone.0036148

15944 Motohiro Tagaya, Nobutaka Hanagata, Toshiyuki Ikoma, Takaomi Kobayashi, Kota Shiba, Tomohiko Yoshioka, Junzo Tnaka Cytotoxicity and Cancer Detection Ability of the Luminescent Nanoporous Silica Spheres Immobilized with Folic Acid Derivative Key Engineering Materials 2012 529-530:630-635 DOI: 10.4028/www.scientific.net/kem.529-530.630

15966 Masumi Yamada, Sari Sugaya, Yoji Naganuma, Minoru Seki Microfluidic synthesis of chemically and physically anisotropic hydrogel microfibers for guided cell growth and networking Soft Matter 2012 8:3122 DOI: 10.1039/c2sm07263g

15970 Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla-Al-Mamun, Yuji Horie, Hirotaka Manaka Enhancement of cumulative photoirradiated and ac magnetic-field induced cancer (HeLa) cell killing efficacy of mixed α and γ-Fe2O3 magnetic nanoparticles New Journal of Chemistry 2012 36:1201 DOI: 10.1039/c2nj40029d

15972 Masahito BAN, Yuuya KOGI, Fusako SASAKI Cytotoxicity of Photosensitizing Crystalline C60 Particles Formed by Ink-jet Method Journal of the Imaging Society of Japan 2012 51:496-500 DOI: 10.11370/isj.51.496

15974 Burroughs AM, Kawano M, Ando Y, Daub CO, Hayashizaki Y. pre-miRNA profiles obtained through application of locked nucleic acids and deep sequencing reveals complex 5'/3' arm variation including concomitant cleavage and polyuridylation patterns Nucleic Acids Res 2012 40(4):1424-37 PubMed ID: 22058130 DOI: 10.1093/nar/gkr903

15975 Taira N, Mimoto R, Kurata M, Yamaguchi T, Kitagawa M, Miki Y, Yoshida K. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells J Clin Invest 2012 122(3):859-72 PubMed ID: 22307329 DOI: 10.1172/JCI60818

15976 Takuma TSUJI, and Jiro USUKURA Assessment on a Biological Toxicity Caused by Single-walled Carbon Nanotubes Nano Biomedicine 2012 4:125-132 DOI: 10.11344/nano.4.125

15977 Sato H, Yamada R, Yanagihara M, Okuzawa H, Iwata H, Kurosawa A, Ichinomiya S, Suzuki R, Okabe H, Yano T, Kumamoto T, Suzuki N, Ishikawa T, Ueno K. New 2-aryl-1,4-naphthoquinone-1-oxime methyl ether compound induces microtubule depolymerization and subsequent apoptosis J Pharmacol Sci 2012 118(4):467-78 PubMed ID: 22447301 DOI: 10.1254/jphs.11229fp

15978 Yuma Yamada, Eriko Kawamura, Hideyoshi Harashima Mitochondrial-targeted DNA delivery using a DF-MITO-Porter, an innovative nano carrier with cytoplasmic and mitochondrial fusogenic envelopes Journal of Nanoparticle Research 2012 14 DOI: 10.1007/s11051-012-1013-3

16569 Ooe H, Chen Q, Kon J, Sasaki K, Miyoshi H, Ichinohe N, Tanimizu N, Mitaka T. Proliferation of rat small hepatocytes requires follistatin expression J Cell Physiol 2012 227(6):2363-70 PubMed ID: 21826650 DOI: 10.1002/jcp.22971

16570 Karasugi K, Kitagishi H, Kano K. Modification of a dioxygen carrier, hemoCD, with PEGylated dendrons for extension of circulation time in the bloodstream Bioconjug Chem 2012 23(12):2365-76 PubMed ID: 23136812 DOI: 10.1021/bc300303z

16577 Hirano Y, Hizume K, Kimura H, Takeyasu K, Haraguchi T, Hiraoka Y. Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation J Biol Chem 2012 287(51):42654-63 PubMed ID: 23100253 DOI: 10.1074/jbc.M112.397950

16578 Yoshikawa Y, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K. Effects of the missense mutations in canine BRCA2 on BRC repeat 3 functions and comparative analyses between canine and human BRC repeat 3 PLoS One 2012 7(10):e45833 PubMed ID: 23071527 DOI: 10.1371/journal.pone.0045833

16579 Bae JY, Mie M, Kobatake E. Targeted gene delivery via PEI complexed with an antibody Appl Biochem Biotechnol 2012 168(8):2184-90 PubMed ID: 23054824 DOI: 10.1007/s12010-012-9928-9

16580 Shiheido H, Naito Y, Kimura H, Genma H, Takashima H, Tokunaga M, Ono T, Hirano T, Du W, Yamada T, Doi N, Iijima S, Hattori Y, Yanagawa H. An anilinoquinazoline derivative inhibits tumor growth through interaction with hCAP-G2, a subunit of condensin II PLoS One 2012 7(9):e44889 PubMed ID: 23028663 DOI: 10.1371/journal.pone.0044889

16581 Kubo T, Yanagihara K, Sato Y, Morita Y, Seyama T. Enhancement of gene silencing effect and membrane permeability by Peptide-conjugated 27-nucleotide small interfering RNA Molecules 2012 17(9):11089-102 PubMed ID: 22983148 DOI: 10.3390/molecules170911089

16582 Ogasawara J, Sakurai T, Kizaki T, Ishibashi Y, Izawa T, Sumitani Y, Ishida H, Radak Z, Haga S, Ohno H. Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes PLoS One 2012 7(7):e40876. PubMed ID: 22815850 DOI: 10.1371/journal.pone.0040876

16583 Shiheido H, Terada F, Tabata N, Hayakawa I, Matsumura N, Takashima H, Ogawa Y, Du W, Yamada T, Shoji M, Sugai T, Doi N, Iijima S, Hattori Y, Yanagawa H. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma PLoS One 2012 7(6):e38878. PubMed ID: 22761710 DOI: 10.1371/journal.pone.0038878

16584 Yamaguchi M, Ito A, Okamoto N, Kawabe Y, Kamihira M. Heat-inducible transgene expression system incorporating a positive feedback loop of transcriptional amplification for hyperthermia-induced gene therapy J Biosci Bioeng 2012 114(4):460-5 PubMed ID: 22658541 DOI: 10.1016/j.jbiosc.2012.05.006

16585 Sakai S, Inagaki H, Liu Y, Matsuyama T, Kihara T, Miyake J, Kawakami K, Taya M. Rapidly serum-degradable hydrogel templating fabrication of spherical tissues and curved tubular structures Biotechnol Bioeng 2012 109(11):2911-9 PubMed ID: 22566297 DOI: 10.1002/bit.24550

16586 Xu L, Li X, Takemura T, Hanagata N, Wu G, Chou LL. Genotoxicity and molecular response of silver nanoparticle (NP)-based hydrogel J Nanobiotechnology 2012 10:16 PubMed ID: 22548743 DOI: 10.1186/1477-3155-10-16

16587 Toyama K, Yamada M, Seki M. Isolation of cell nuclei in microchannels by short-term chemical treatment via two-step carrier medium exchange Biomed Microdevices 2012 14(4):751-7 PubMed ID: 22544390 DOI: 10.1007/s10544-012-9653-8

16588 Kondo Y, Ishitsuka Y, Kadowaki D, Kuroda M, Tanaka Y, Nagatome M, Irikura M, Hirata S, Sato K, Maruyama T, Hamasaki N, Irie T. Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti-oxidant in HeLa cells Biol Pharm Bull 2012 35(4):606-11 PubMed ID: 22466568 DOI: 10.1248/bpb.35.606

16589 Nakase I, Konishi Y, Ueda M, Saji H, Futaki S. Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo J Control Release 2012 159(2):181-8 PubMed ID: 22285548 DOI: 10.1016/j.jconrel.2012.01.016

16590 Sakai S, Inamoto K, Liu Y, Tanaka S, Arii S, Taya M. Multicellular tumor spheroid formation in duplex microcapsules for analysis of chemosensitivity Cancer Sci 2012 103(3):549-54 PubMed ID: 22168771 DOI: 10.1111/j.1349-7006.2011.02187.x

16591 Yamada Y, Harashima H. Delivery of bioactive molecules to the mitochondrial genome using a membrane-fusing, liposome-based carrier, DF-MITO-Porter Biomaterials 2012 33(5):1589-95 PubMed ID: 22105068 DOI: 10.1016/j.biomaterials.2011.10.082

16592 Li Y, Mitsuhashi S, Ikejo M, Miura N, Kawamura T, Hamakubo T, Ubukata M. Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1 Biosci Biotechnol Biochem 2012 76(3):486-94 PubMed ID: 22451389 DOI: 10.1271/bbb.110774

16593 Takahashi M, Elbarbary RA, Abe M, Sato M, Yoshida T, Yamada Y, Tamura M, Nashimoto M. Elimination of specific miRNAs by naked 14-nt sgRNAs PLoS One 2012 7(6):e38496 PubMed ID: 22675569 DOI: 10.1371/journal.pone.0038496

16594 Nogawa T, Takahashi S, Okano A, Kawatani M, Uramoto M, Saito T, Osada H. Spirotoamides A and B, novel 6,6-spiroacetal polyketides isolated from a microbial metabolite fraction library J Antibiot (Tokyo) 2012 65(3):123-128 PubMed ID: 22186593 DOI: 10.1038/ja.2011.121

7809 Ochiai K, Yoshikawa Y, Yoshimatsu K, Oonuma T, Tomioka Y, Takeda E, Arikawa J, Mominoki K, Omi T, Hashizume K, Morimatsu M. Valine 1532 of human BRC repeat 4 plays an important role in the interaction between BRCA2 and RAD51. FEBS Lett. 2011 585:1771-7 PubMed ID: 21601571 DOI: 10.1016/j.febslet.2011.05.027

7923 Okano K, Yu D, Matsui A, Maezawa Y, Hosokawa Y, Kira A, Matsubara M, Liau I, Tsubokawa H, Masuhara H. Induction of cell-cell connections by using in situ laser lithography on a perfluoroalkyl-coated cultivation platform. Chembiochem 2011 12:795-801 PubMed ID: 21341350 DOI: 10.1002/cbic.201000497

7953 Watanabe S, Wakasugi K. Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity. PLoS ONE 2011 6:e16808 PubMed ID: 21304818 DOI: 10.1371/journal.pone.0016808

7983 Kondo T, Hamao K, Kamijo K, Kimura H, Morita M, Takahashi M, Hosoya H. Enhancement of myosin II/actin turnover at the contractile ring induces slower furrowing in dividing HeLa cells. Biochem. J. 2011 435:569-76 PubMed ID: 21231914 DOI: 10.1042/BJ20100837

7995 Kaneko S, Nakayama H, Yoshino Y, Fushimi D, Yamaguchi K, Horiike Y, Nakanishi J. Photocontrol of cell adhesion on amino-bearing surfaces by reversible conjugation of poly(ethylene glycol) via a photocleavable linker. Phys Chem Chem Phys 2011 13:4051-9 PubMed ID: 21225032 DOI: 10.1039/c0cp02013c

8016 Li G, Kawashima H, Ogose A, Ariizumi T, Xu Y, Hotta T, Urata Y, Fujiwara T, Endo N. Efficient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirus. J. Cancer Res. Clin. Oncol. 2011 137:1037-51 PubMed ID: 21193997 DOI: 10.1007/s00432-010-0969-6

8025 Furukawa R, Yamada Y, Takenaga M, Igarashi R, Harashima H. Octaarginine-modified liposomes enhance the anti-oxidant effect of Lecithinized superoxide dismutase by increasing its cellular uptake. Biochem. Biophys. Res. Commun. 2011 404:796-801 PubMed ID: 21168389 DOI: 10.1016/j.bbrc.2010.12.062

3711 Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H. Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells. Cancer Sci 2011 102(2):407-13 PubMed ID: 21166957 DOI: 10.1111/j.1349-7006.2010.01808.x

6391 Fujitani N, Takegawa Y, Ishibashi Y, Araki K, Furukawa J, Mitsutake S, Igarashi Y, Ito M, Shinohara Y. Qualitative and quantitative cellular glycomics of glycosphingolipids based on rhodococcal endoglycosylceramidase-assisted glycan cleavage, glycoblotting-assisted sample preparation, and matrix-assisted laser desorption ionization tandem time-of-flight mass spectrometry analysis. J Biol Chem 2011 286(48):41669-79 PubMed ID: 21965662 DOI: 10.1074/jbc.M111.301796

4886 Ikegami D, Akiyama H, Suzuki A, Nakamura T, Nakano T, Yoshikawa H, Tsumaki N. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 2011 138(8):1507-19 PubMed ID: 21367821 DOI: 10.1242/dev.057802

8358 Zhang W, Tsurushima H, Oyane A, Yazaki Y, Sogo Y, Ito A, Matsumura A. BMP-2 gene-fibronectin-apatite composite layer enhances bone formation. J Biomed Sci 2011 18:62 PubMed ID: 21859498 DOI: 10.1186/1423-0127-18-62

12233 Yuma Yamada, Ryo Furukawa, Yukari Yasuzaki, Hideyoshi Harashima Dual function MITO-Porter, a nano carrier integrating both efficient cytoplasmic delivery and mitochondrial macromolecule delivery Mol Ther 2011 19(8):1449-56 PubMed ID: 21694702 DOI: 10.1038/mt.2011.99

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16169 Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla-Al-Mamun, Yuji Horie Photocatalytic and AC magnetic-field induced enhanced cytotoxicity of Fe3O4–TiO2 core-shell nanocomposites against HeLa cells Catalysis Communications 2011 16:39-44 DOI: 10.1016/j.catcom.2011.08.039

16311 Md. Shariful Islam, Yoshihumi Kusumoto, Md. Abdulla-Al-Mamun, Yuji Horie Synergistic Cell Killing by Magnetic and Photoirradiation Effects of Neck-structured α-Fe2O3against Cancer (HeLa) Cells Chemistry Letters 2011 40:773-775 DOI: 10.1246/cl.2011.773

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16317 Ishikawa T, Saito T, Kurosawa A, Watanabe T, Maruyama S, Ichikawa Y, Yamada R, Okuzawa H, Sato H, Ueno K. 2-Aryl-1,4-naphthoquinone-1-oxime methyl ethers: their cytotoxic activity Chem Pharm Bull (Tokyo) 2011 59(4):472-5 PubMed ID: 21467676 DOI: 10.1248/cpb.59.472

16318 Toshiro Kibe, Michiko Kishida, Masayuki Kamino, Mikio Iijima, Lin Chen, Mika Habu, Akihiko Miyawaki, Hiroshi Hijioka, Norifumi Nakamura, Tohru Kiyono, Shosei Kishida Immortalization and characterization of normal oral epithelial cells without using HPV and SV40 genes Oral Science International 2011 8:20-28 DOI: 10.1016/s1348-8643(11)00009-7

16564 Ishibashi O, Ali MM, Luo SS, Ohba T, Katabuchi H, Takeshita T, Takizawa T. Short RNA duplexes elicit RIG-I-mediated apoptosis in a cell type- and length-dependent manner Sci Signal 2011 4(198):ra74. PubMed ID: 22067459 DOI: 10.1126/scisignal.2001614

16565 Kaida A, Sawai N, Sakaguchi K, Miura M. Fluorescence kinetics in HeLa cells after treatment with cell cycle arrest inducers visualized with Fucci (fluorescent ubiquitination-based cell cycle indicator) Cell Biol Int 2011 35(4):359-63 PubMed ID: 21231917 DOI: 10.1042/CBI20100643

16566 Yamasuji M, Shibata T, Kabashima T, Kai M. Chemiluminescence detection of telomere DNA in human cells on a membrane by using fluorescein-5-isothiocyanate-labeled primers Anal Biochem 2011 413(1):50-4 PubMed ID: 21300019 DOI: 10.1016/j.ab.2011.01.047

16567 Sakurai Y, Hatakeyama H, Sato Y, Akita H, Takayama K, Kobayashi S, Futaki S, Harashima H. Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA Biomaterials 2011 32(24):5733-42 PubMed ID: 21605898 DOI: 10.1016/j.biomaterials.2011.04.047

16568 Shaheen SM, Akita H, Yamashita A, Katoono R, Yui N, Biju V, Ishikawa M, Harashima H. Quantitative analysis of condensation/decondensation status of pDNA in the nuclear sub-domains by QD-FRET Nucleic Acids Res 2011 39(7):e48 PubMed ID: 21288880 DOI: 10.1093/nar/gkq1327

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18459 Nakamura T, Tamura A, Murotani H, Oishi M, Jinji Y, Matsuishi K, Nagasaki Y. Large payloads of gold nanoparticles into the polyamine network core of stimuli-responsive PEGylated nanogels for selective and noninvasive cancer photothermal therapy Nanoscale 2010 2(5):739-46 PubMed ID: 20648319 DOI: 10.1039/b9nr00329k

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18574 Sato Y, Hatakeyama H, Harashima H. Ornithine and tryptophan analogs as efficient polycations for short interference RNA delivery to tumor cells Biol Pharm Bull 2010 33(7):1246-9 PubMed ID: 20606322 DOI: 10.1248/bpb.33.1246

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6119 Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T. Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion. Biochem Biophys Res Commun 2010 391(2):1192-6 PubMed ID: 20004645 DOI: 10.1016/j.bbrc.2009.12.029

6305 Aoki S, Honma M, Kariya Y, Nakamichi Y, Ninomiya T, Takahashi N, Udagawa N, Suzuki H. Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis. J Bone Miner Res 2010 25(9):1907-2 PubMed ID: 20560139 DOI: 10.1002/jbmr.89

4665 Saito T, Fukai A, Mabuchi A, Ikeda T, Yano F, Ohba S, Nishida N, Akune T, Yoshimura N, Nakagawa T, Nakamura K, Tokunaga K, Chung UI, Kawaguchi H. Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med 2010 16(6):678-86 PubMed ID: 20495570 DOI: 10.1038/nm.2146

12759 Maruichi T, Fukami T, Nakajima M, Yokoi T. Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2) Biochem Pharmacol 2010 79(2):288-95 PubMed ID: 19715681 DOI: 10.1016/j.bcp.2009.08.019

12760 Ando H, Horibata Y, Yamashita S, Oyama T, Sugimoto H. Low-density lipoprotein and oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase in vitro Biochim Biophys Acta 2010 1801(4):487-95 PubMed ID: 20045741 DOI: 10.1016/j.bbalip.2009.12.014

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16518 Li F, Awale S, Tezuka Y, Kadota S. Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines Nat Prod Commun 2010 5(10):1601-6. PubMed ID: 21121257

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8606 Hamao K, Morita M, Hosoya H. New function of the proline rich domain in dynamin-2 to negatively regulate its interaction with microtubules in mammalian cells. Exp. Cell Res. 2009 315:1336-45 PubMed ID: 19331814 DOI: 10.1016/j.yexcr.2009.01.025

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8711 Kawaai K, Hisatsune C, Kuroda Y, Mizutani A, Tashiro T, Mikoshiba K. 80K-H interacts with inositol 1,4,5-trisphosphate (IP3) receptors and regulates IP3-induced calcium release activity. J. Biol. Chem. 2009 284:372-80 PubMed ID: 18990696 DOI: 10.1074/jbc.M805828200

18477 Sakurai Y, Hatakeyama H, Akita H, Oishi M, Nagasaki Y, Futaki S, Harashima H. Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system Biol Pharm Bull 2009 32(5):928-32 PubMed ID: 19420766 DOI: 10.1248/bpb.32.928

18480 Hirakawa H, Kodama T, Takumi-Kobayashi A, Honda T, Yamaguchi A. Secreted indole serves as a signal for expression of type III secretion system translocators in enterohaemorrhagic Escherichia coli O157:H7 Microbiology (Reading) 2009 155(Pt 2):541-550 PubMed ID: 19202102 DOI: 10.1099/mic.0.020420-0

6301 Kariya Y, Honma M, Aoki S, Chiba A, Suzuki H. Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells. J Bone Miner Res 2009 24(10):1741-52 PubMed ID: 19419298 DOI: 10.1359/jbmr.090409

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

10911 Kayoko Kawai, Akiko Saito, Tatsuhiko Sudo, Hiroyuki Osada A p38 Mitogen-Activated Protein Kinase Inhibitor Screening Method Using Growth Recovery of Escherichia Coli as an Index Anal Biochem 2009 388(1):128-33 PubMed ID: 19248755 DOI: 10.1016/j.ab.2009.02.022

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18310 Uemori A, Ohgushi A, Yasutake K, Maeda M, Mizuki E, Ohba M. Parasporin-1Ab, a novel Bacillus thuringiensis cytotoxin preferentially active on human cancer cells in vitro Anticancer Res 2008 28(1A):91-5 PubMed ID: 18383829

18317 Yasutake K, Uemori A, Binh ND, Mizuki E, Ohba M. Identification of parasporin genes in Vietnamese isolates of Bacillus thuringiensis Z Naturforsch C J Biosci 2008 63(1-2):139-43 PubMed ID: 18386503 DOI: 10.1515/znc-2008-1-225

18318 Nakamura A, Nakajima M, Yamanaka H, Fujiwara R, Yokoi T. Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines Drug Metab Dispos 2008 36(8):1461-4 PubMed ID: 18480185 DOI: 10.1124/dmd.108.021428

18378 Yamada Y, Akita H, Kamiya H, Kogure K, Yamamoto T, Shinohara Y, Yamashita K, Kobayashi H, Kikuchi H, Harashima H. MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion Biochim Biophys Acta 2008 1778(2):423-32 PubMed ID: 18054323 DOI: 10.1016/j.bbamem.2007.11.002

18380 Kurata N, Shishido T, Muraoka M, Tanaka T, Ogino C, Fukuda H, Kondo A. Specific protein delivery to target cells by antibody-displaying bionanocapsules J Biochem 2008 144(6):701-7. PubMed ID: 18838435 DOI: 10.1093/jb/mvn131

8759 Watanabe S, Wakasugi K. Zebrafish neuroglobin is a cell-membrane-penetrating globin. Biochemistry 2008 47:5266-70 PubMed ID: 18416560 DOI: 10.1021/bi800286m

18603 Zhang Y, Li Y, Shibahara S, Takahashi K. Synergistic activation of the human adrenomedullin gene promoter by Sp1 and AP-2alpha Peptides 2008 29(3):465-72 PubMed ID: 17719138 DOI: 10.1016/j.peptides.2007.07.015

18604 Suzuki R, Yamada Y, Harashima H. Development of small, homogeneous pDNA particles condensed with mono-cationic detergents and encapsulated in a multifunctional envelope-type nano device Biol Pharm Bull 2008 31(6):1237-43 PubMed ID: 18520061 DOI: 10.1248/bpb.31.1237

18703 Kawai K, Saito A, Sudo T, Osada H. Specific regulation of cytokine-dependent p38 MAP kinase activation by p62/SQSTM1 J Biochem 2008 143(6):765-72 PubMed ID: 18296712 DOI: 10.1093/jb/mvn027

3576 Ikeda M, Kanouchi H, Minatogawa Y. Characterization of peroxisomal targeting signals on alanine: glyoxylate aminotransferase. Biol Pharm Bull 2008 31(1):131-4 PubMed ID: 18175955 DOI: 10.1248/bpb.31.131

9068 Yasuhiro Yamasaki, Daisuke Katsuo, Seiichiro Nakayasu, Cristina Salati, JingJing Duan, Yanan Zou, Yukihiko Matsuyama, Kenichi Yamaguchi, Tatsuya Oda Purification and Characterization of a Novel High Molecular Weight Exotoxin Produced by Red Tide Phytoplankton, Alexandrium Tamarense J Biochem Mol Toxicol 2008 22 (6), 405-15 PubMed ID: 19111002 DOI: 10.1002/jbt.20253

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16645 Li F, Awale S, Tezuka Y, Kadota S. Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship Bioorg Med Chem 2008 16(10):5434-40 PubMed ID: 18440233 DOI: 10.1016/j.bmc.2008.04.016

16656 Shimizu N, Yoshikawa N, Wada T, Handa H, Sano M, Fukuda K, Suematsu M, Sawai T, Morimoto C, Tanaka H. Tissue- and context-dependent modulation of hormonal sensitivity of glucocorticoid-responsive genes by hexamethylene bisacetamide-inducible protein 1 Mol Endocrinol 2008 22(12):2609-23 PubMed ID: 18801933 DOI: 10.1210/me.2008-0101

8791 Wakasugi K. Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity. Biochemistry 2007 46:11291-8 PubMed ID: 17877375 DOI: 10.1021/bi7012068

8808 Nakayama T, Nomura N, Matsumura M. The effect of copper concentration on the virulence of pathogenic Vibrio harveyi. J. Appl. Microbiol. 2007 102:1300-6 PubMed ID: 17448165 DOI: 10.1111/j.1365-2672.2006.03226.x

18609 Shibata H, Suzuki H, Yoshida H, Maki M. ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner Biochem Biophys Res Commun 2007 353(3):756-63 PubMed ID: 17196169 DOI: 10.1016/j.bbrc.2006.12.101

3577 Ikeda M, Inoue S, Muramatsu M, Minatogawa Y. Characterization and identification of a steroid receptor-binding protein, SRB-RGS. Biol Pharm Bull 2007 30(6):1056-64 PubMed ID: 17541154 DOI: 10.1248/bpb.30.1056

7380 Yamamoto T, Kambe F, Cao X, Lu X, Ishiguro N, Seo H. Parathyroid hormone activates phosphoinositide 3-kinase-Akt-Bad cascade in osteoblast-like cells. Bone 2007 40(2):354-9 PubMed ID: 17046344 DOI: 10.1016/j.bone.2006.09.002

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9060 Paola Neri, Saori Itoh Nagano, Shin-ichiro Yokoyama, Hirofumi Dohi, Kazukiyo Kobayashi, Tsuyoshi Miura, Toshiyuki Inazu, Tsuyoshi Sugiyama, Yoshihiro Nishida, Hiroshi Mori Neutralizing Activity of Polyvalent Gb3, Gb2 and Galacto-Trehalose Models Against Shiga Toxins Microbiol Immunol 2007 51 (6), 581-92 PubMed ID: 17579269 DOI: 10.1111/j.1348-0421.2007.tb03944.x

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3389 Akita, Hidetaka, Tanimoto, Mitsuhide, Masuda, Tomoya, Kogure, Kentaro, Hama, Susumu, Ninomiya, Keiko, Futaki, Shiroh, Harashima, Hideyoshi Evaluation of the nuclear delivery and intra-nuclear transcription of plasmid DNA condensed with micro (mu) and NLS-micro by cytoplasmic and nuclear microinjection: a comparative study with poly-L-lysine. J Gene Med 2006 8:198-206 PubMed ID: 16285003 DOI: 10.1002/jgm.839

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8860 Horiuchi S, Aoyama Y. Systematic lactose-functionalization of amphiphilic octaamine macrocycle as a gene carrier. Optimization of the charge, size, toxicity, and receptor factors for hepatocyte targeting. J Control Release 2006 116:107-14 PubMed ID: 16905218 DOI: 10.1016/j.jconrel.2006.07.004

8864 Nakayama T, Nomura N, Matsumura M. Study on the relationship of protease production and luminescence in Vibrio harveyi. J. Appl. Microbiol. 2006 101:200-5 PubMed ID: 16834607 DOI: 10.1111/j.1365-2672.2006.02887.x

8880 Nakayama T, Ito E, Nomura N, Nomura N, Matsumura M. Comparison of Vibrio harveyi strains isolated from shrimp farms and from culture collection in terms of toxicity and antibiotic resistance. FEMS Microbiol. Lett. 2006 258:194-9 PubMed ID: 16640572 DOI: 10.1111/j.1574-6968.2006.00225.x

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18622 Okumura H, Nakazawa J, Tsuganezawa K, Usui T, Osada H, Matsumoto T, Tanaka A, Yokoyama S. Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells Toxicol Lett 2006 166(1):44-52 PubMed ID: 16814965 DOI: 10.1016/j.toxlet.2006.05.011

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3413 Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells. J Biochem 2005 138:663-72 PubMed ID: 16428294 DOI: 10.1093/jb/mvi177

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2955 Yoshikawa N, Yamamoto K, Shimizu N, Yamada S, Morimoto C, Tanaka H The distinct agonistic properties of the phenylpyrazolosteroid cortivazol reveal interdomain communication within the glucocorticoid receptor. Mol Endocrinol 2005 19:1110-24 PubMed ID: 15677712 DOI: 10.1210/me.2004-0264

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2881 Fukushima-Nakase Y, Naoe Y, Taniuchi I, Hosoi H, Sugimoto T, Okuda T. Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Blood 2005 105(11):4298-307 PubMed ID: 15713794 DOI: 10.1182/blood-2004-08-3372

2957 Isogawa Y, Kon T, Inoue T, Ohkura R, Yamakawa H, Ohara O, Sutoh K. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. Biochemistry 2005 44(16):6190-6 PubMed ID: 15835906 DOI: 10.1021/bi0475931

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