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17483
Nakatsu D, Kunishige R, Taguchi Y, Shinozaki-Narikawa N, Osaka K, Yokomizo K, Ishida M, Takei S, Yamasaki S, Hagiya K, Hattori K, Tsukamoto T, Murata M, Kano F.
BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions
Stem Cell Reports
2023
18(3):688-705
PubMed ID: 36764297
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21125
Togo H, Terada K, Ujitsugu A, Hirose Y, Takeuchi H, Kusunoki M.
Fabrication Scaffold with High Dimensional Control for Spheroids with Undifferentiated iPS Cell Properties.
Cells
2023
12(2)
PubMed ID: 36672213
DOI: 10.3390/cells12020278
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21170
Kawamata M, Suzuki HI, Kimura R, Suzuki A.
Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs.
Nat Biomed Eng
2023
PubMed ID: 37037965
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21329
Riesenberg S, Kanis P, Macak D, Wollny D, Düsterhöft D, Kowalewski J, Helmbrecht N, Maricic T, Pääbo S.
Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.
Nat Methods
2023
PubMed ID: 37474806
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21371
Bressan C, Snapyan M, Snapyan M, Klaus J, di Matteo F, Robertson SP, Treutlein B, Parent M, Cappello S, Saghatelyan A.
Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia.
EMBO Mol Med
2023
e16908
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17541
He Z, Maynard A, Jain A, Gerber T, Petri R, Lin HC, Santel M, Ly K, Dupré JS, Sidow L, Sanchis Calleja F, Jansen SMJ, Riesenberg S, Camp JG, Treutlein B.
Lineage recording in human cerebral organoids
Nat Methods
2022
19(1):90-99
PubMed ID: 34969984
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17579
Hirata M, Ichiyanagi T, Katoh H, Hashimoto T, Suzuki H, Nitta H, Kawase M, Nakai R, Imamura M, Ichiyanagi K.
Sequence divergence and retrotransposon insertion underlie interspecific epigenetic differences in primates
Mol Biol Evol
2022
39(10):msac208
PubMed ID: 36219870
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20238
Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N.
Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Autophagy
2022
1-20
PubMed ID: 34286667
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16702
Song D, Takahashi G, Zheng YW, Matsuo-Takasaki M, Li J, Takami M, An Y, Hemmi Y, Miharada N, Fujioka T, Noguchi M, Nakajima T, Saito MK, Nakamura Y, Oda T, Miyaoka Y, Hayashi Y.
Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes
Hum Mol Genet
2022
Apr 7;ddac080
PubMed ID: 35388883
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16844
Cruceanu C, Dony L, Krontira AC, Fischer DS, Roeh S, Di Giaimo R, Kyrousi C, Kaspar L, Arloth J, Czamara D, Gerstner N, Martinelli S, Wehner S, Breen MS, Koedel M, Sauer S, Sportelli V, Rex-Haffner M, Cappello S, Theis FJ, Binder EB.
Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study
Am J Psychiatry
2022
179(5):375-387
PubMed ID: 34698522
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20851
Chow SYA, Nakayama K, Osaki T, Sugiyama M, Yamada M, Takeuchi H, Ikeuchi Y.
Human sensory neurons modulate melanocytes through secretion of RGMB.
Cell Rep
2022
40(12):111366
PubMed ID: 36130522
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20875
Okawa R, Sogawa K, Shiozaki M, Yachiku K, Miura T, Shibata T, Ezoe S.
The effects of continuous exposure to low-dose chlorine dioxide gas on the characteristics of induced pluripotent stem cells.
Regen Ther
2022
21:250-257
PubMed ID: 36092508
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20878
Fleck JS, Jansen SMJ, Wollny D, Zenk F, Seimiya M, Jain A, Okamoto R, Santel M, He Z, Camp JG, Treutlein B.
Inferring and perturbing cell fate regulomes in human brain organoids.
Nature
2022
PubMed ID: 36198796
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20936
Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S.
A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.
Med (N Y)
2022
PubMed ID: 36395757
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13380
Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y.
Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.
FEBS Open Bio
2021
11(2):354-366
PubMed ID: 33301617
DOI: 10.1002/2211-5463.13060
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20014
Matsuo M, Nadanaka S, Soga M, Sugiyama T, Serigano S, Shimano K, Ichinose F, Nakamura T, Maeda T, Houkin K, Era T, Kitagawa H.
Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease.
Sci Rep
2021
11(1):1552
PubMed ID: 33452387
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20221
Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, Kawamura Y, Ueda Y, Takai H, Mandai M, Kondoh E.
Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells
Sci Rep
2021
11(1):14167
PubMed ID: 34239021
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20257
Lin HC, He Z, Ebert S, Schörnig M, Santel M, Nikolova MT, Weigert A, Hevers W, Kasri NN, Taverna E, Camp JG, Treutlein B.
NGN2 induces diverse neuron types from human pluripotency.
Stem Cell Reports
2021
PubMed ID: 34358451
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15507
Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T.
Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells
Nat Protoc
2021
16(2):919-936
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15523
Abe T, Uosaki H, Shibata H, Hara H, Sarentonglaga B, Nagao Y, Hanazono Y.
Fetal sheep support the development of hematopoietic cells in vivo from human induced pluripotent stem cells
Exp Hematol
2021
95:46-57.e8
PubMed ID: 33395577
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20366
Hisatsune C, Shimada T, Miyamoto A, Lee A, Yamagata K.
Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca2+ Influx via L-Type Ca2+ Channels.
J Neurosci
2021
41(39):8134-8149
PubMed ID: 34417327
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15683
Vita Stepanova, Kaja Ewa Moczulska, Guido N Vacano, Ilia Kurochkin, Xiangchun Ju, Stephan Riesenberg, Dominik Macak, Tomislav Maricic, Linda Dombrowski, Maria Schörnig, Konstantinos Anastassiadis, Oliver Baker, Ronald Naumann, Ekaterina Khrameeva, Anna Vanushkina, Elena Stekolshchikova, Alina Egorova, Anna Tkachev, Randall Mazzarino, Nathan Duval, Dmitri Zubkov, Patrick Giavalisco, Terry G Wilkinson, David Patterson, Philipp Khaitovich, Svante Pääbo
Reduced purine biosynthesis in humans after their divergence from Neandertals
eLife
2021
10:2021-5-4
PubMed ID: 33942714
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15899
Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T.
eIF2B-capturing viral protein NSs suppresses the integrated stress response
Nat Commun
2021
12(1):7102
PubMed ID: 34876589
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20491
Tadokoro S, Tokuyama-Toda R, Tatehara S, Ide S, Umeki H, Miyoshi K, Noma T, Satomura K.
A New Induction Method for the Controlled Differentiation of Human-Induced Pluripotent Stem Cells Using Frozen Sections.
Cells
2021
10(11)
PubMed ID: 34831050
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6879
Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H.
Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells.
Cell Rep
2020
30(1):18-24
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Tomoyo Sawada, Thomas E Chater, Yohei Sasagawa, Mika Yoshimura, Noriko Fujimori-Tonou, Kaori Tanaka, Kynon J M Benjamin, Apuã C M Paquola, Jennifer A Erwin, Yukiko Goda, Itoshi Nikaido, Tadafumi Kato
Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids
Mol Psychiatry
2020
25(11):2695-2711
PubMed ID: 32764691
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11989
Dayem AA, Won J, Goo HG, Yang GM, Seo DS, Jeon BM, Choi HY, Park SE, Lim KM, Jang SH, Lee SB, Choi SB, Kim K, Kang GH, Yeon GB, Kim DS, Cho SG.
The immobilization of fibronectin- and fibroblast growth factor 2-derived peptides on a culture plate supports the attachment and proliferation of human pluripotent stem cells.
Stem Cell Res
2020
PubMed ID: 31981882
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Misawa R, Minami T, Okamoto A, Ikeuchi Y.
A Light-Inducible Hedgehog Signaling Activator Modulates Proliferation and Differentiation of Neural Cells.
ACS Chem Biol
2020
PubMed ID: 32343549
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Maurissen TL, Woltjen K.
Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation.
Nat Commun
2020
PubMed ID: 32513994
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Yokouchi Y, Suzuki S, Ohtsuki N, Yamamoto K, Noguchi S, Soejima Y, Goto M, Ishioka K, Nakamura I, Suzuki S, Takenoshita S, Era T.
Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing.
Sci Rep
2020
PubMed ID: 32811847
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Sim H, Seo JH, Kim J, Oh M, Lee JE, Baek A, Lee SY, Chung SK, Son MY, Chae JI, Jeon YJ, Kim J.
Quantitative Proteomic Analysis of Primitive Neural Stem Cells from LRRK2 G2019S-Associated Parkinson's Disease Patient-Derived iPSCs.
Life (Basel)
2020
PubMed ID: 33297425
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Ayo-Martin AC, Kyrousi C, Di Giaimo R, Cappello S.
GNG5 Controls the Number of Apical and Basal Progenitors and Alters Neuronal Migration During Cortical Development
Front Mol Biosci
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14943
Krieger TG, Tirier SM, Park J, Jechow K, Eisemann T, Peterziel H, Angel P, Eils R, Conrad C.
Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics
Neuro Oncol
2020
22(8):1138-1149
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16212
Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, Masaaki Oyama, Yoshiho Ikeuchi, Shintaro Iwasaki, Yukihide Tomari
A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation
PLoS Biol
2020
18(3):e3000632
PubMed ID: 32163402
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16885
Osman A, Oze M, Afify SM, Hassan G, El-Ghlban S, Nawara HM, Fu X, Zahra MH, Seno A, Winer I, Salomon DS, Seno M.
Tumor-associated macrophages derived from cancer stem cells
Acta Histochem
2020
122(8):151628
PubMed ID: 32992123
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11304
Ueda M, Hashimoto Y, Honda Y, Baba S, Morita S.
Comparison of the characteristics of mesenchymal stem-like cells derived by integration-free induced pluripotent stem cells in different single-cell culture media under feeder-free conditions.
Med Mol Morphol
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PubMed ID: 30446810
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Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, Miura T, Matsuyama A, Sato Y.
SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.
Nat Commun
2019
10(1):2175
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Kirihara T, Luo Z, Chow SYA, Misawa R, Kawada J, Shibata S, Khoyratee F, Vollette CA, Volz V, Levi T, Fujii T, Ikeuchi Y.
A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions.
iScience
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14:301-311
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Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y, Tomonaga K.
RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs.
Mol Ther Methods Clin Dev
2019
14:47-55
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Aoki H, Yamashita M, Hashita T, Nakayama M, Yagi M, Iwao T, Matsunaga T.
Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures.
Biochem. Biophys. Res. Commun.
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515(4):672-678
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Riesenberg S, Chintalapati M, Macak D, Kanis P, Maricic T, Pääbo S.
Simultaneous precise editing of multiple genes in human cells.
Nucleic Acids Res.
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Kanton S, Boyle MJ, He Z, Santel M, Weigert A, Sanchís-Calleja F, Guijarro P, Sidow L, Fleck JS, Han D, Qian Z, Heide M, Huttner WB, Khaitovich P, Pääbo S, Treutlein B, Camp JG.
Organoid single-cell genomic atlas uncovers human-specific features of brain development.
Nature
2019
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Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Risako Onodera, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima
Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice
Journal of Inclusion Phenomena and Macrocyclic Chemistry
2019
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Kimura Y, Shofuda T, Higuchi Y, Nagamori I, Oda M, Nakamori M, Onodera M, Kanematsu D, Yamamoto A, Katsuma A, Suemizu H, Nakano T, Kanemura Y, Mochizuki H.
Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy
Stem Cells Transl Med
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Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.
Sci Rep
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Recombinant laminin fragments endowed with collagen-binding activity: A tool for conferring laminin-like cell-adhesive activity to collagen matrices.
Matrix Biol.
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Tumorigenicity-associated characteristics of human iPS cell lines.
PLoS ONE
2018
PubMed ID: 30286143
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Ikeda K, Kawasaki Y, Matsuda H, Kishida S, Iwasaki A, Ohata S, Urashima Y, Hirotani Y.
Approach for differentiating trophoblast cell lineage from human induced pluripotent stem cells with retinoic acid in the absence of bone morphogenetic protein 4.
Placenta
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PubMed ID: 30415744
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5348
Yoshinori Hasegawa, Masashi Ikeno, Nobutaka Suzuki, Manabu Nakayama, Osamu Ohara
Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells
Biology Methods and Protocols
2018
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Yokoi T, Tanaka T, Matsuzaka E, Tamalu F, Watanabe SI, Nishina S, Azuma N.
Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells.
Sci Rep
2017
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Kawada J, Kaneda S, Kirihara T, Maroof A, Levi T, Eggan K, Fujii T, Ikeuchi Y.
Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons.
Stem Cell Reports
2017
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Koui Y, Kido T, Ito T, Oyama H, Chen SW, Katou Y, Shirahige K, Miyajima A.
An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells.
Stem Cell Reports
2017
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Ikeda K, Nagata S, Okitsu T, Takeuchi S.
Cell fiber-based three-dimensional culture system for highly efficient expansion of human induced pluripotent stem cells.
Sci Rep
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Shimizu Y, Satou M, Hayashi K, Nakamura Y, Fujimaki M, Horibata Y, Ando H, Watanabe T, Shiobara T, Chibana K, Takemasa A, Sugimoto H, Anzai N, Ishii Y.
Matrix-assisted laser desorption/ionization imaging mass spectrometry reveals changes of phospholipid distribution in induced pluripotent stem cell colony differentiation.
Anal Bioanal Chem
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Zuiki M, Chiyonobu T, Yoshida M, Maeda H, Yamashita S, Kidowaki S, Hasegawa T, Gotoh H, Nomura T, Ono K, Hosoi H, Morimoto M.
Luteolin attenuates interleukin-6-mediated astrogliosis in human iPSC-derived neural aggregates: A candidate preventive substance for maternal immune activation-induced abnormalities.
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Visualization of migration of human cortical neurons generated from induced pluripotent stem cells.
J. Neurosci. Methods
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Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status.
Stem Cells Int
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Sci Rep
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Regeneration of CD8αβ T Cells from T-cell-Derived iPSC Imparts Potent Tumor Antigen-Specific Cytotoxicity.
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Kido T, Koui Y, Suzuki K, Kobayashi A, Miura Y, Chern EY, Tanaka M, Miyajima A.
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
Stem Cell Reports
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Tanaka T, Yokoi T, Tamalu F, Watanabe S, Nishina S, Azuma N.
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Sci Rep
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Examination of a Viral Infection Mimetic Model in Human iPS Cell-Derived Insulin-Producing Cells and the Anti-Apoptotic Effect of GLP-1 Analogue.
PLoS One
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Sasaki H, Wada H, Baghdadi M, Tsuji H, Otsuka R, Morita K, Shinohara N, Seino K.
New Immunosuppressive Cell Therapy to Prolong Survival of Induced Pluripotent Stem Cell-Derived Allografts
Transplantation
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PLoS One
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