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Cell No. : Cell Name
HPS0076 : 409B2  update : 2024/11/08
CommentHuman iPS cell line. HPS0002, HPS0063, HPS0076, HPS0296, HPS0326, HPS3668, HPS4290, HPS4291, HPS4292 are derived from the same person. Cryopreserved by vitrification method.
Comment from the depositor
Terms and conditions1) In relation to the for-profit organizations, please contact iPS Academia Japan, Inc., prior to the utilization of iPS cells. 2) Attach Appendix (non-for-profit) or Appendix (for-profit) to MTA (C-0007 or C-0007p) .
Remarks
Order Form Order Form(C-0042.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor https://www.cira.kyoto-u.ac.jp/
Originator Yamanaka, Shinya
Year of deposit 2011
Animal _human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Female
Age at sampling 36 years
Tissue skin
Classification iPS
Recombinant recombinant
Exogene pCXLE, human Oct3/4, human Sox2, human Klf4, human L-Myc, human Lin28, p53 shRNA
Lifespan infinite
Morphology ES-like
Cellosaurus(Expasy) CVCL_K092
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium Primate ES Cell Medium + 4ng/ml human basic FGF
Antibiotics Free
Passage method 0.25% Trypsin + 0.1% collagenase type IV + 20% KSR + 1mM CaCl2 + PBS(-)
Coating dish 0.1% gelatin coated dish
Culture information Passage ratio 1 : 3-5 split
SC frequency Subculture : once/4-6 days, Medium Renewal : every day
Temperature 37 ℃
CO2 concentration 5 %
Feeder cells SNL 76/7
Feeder treatment X-rays 5000R (or MMC)
Feeder seed cells 1.5-2.5 x 10 6 cells/100 mm dish
Freeze medium DAP213 : Medium + 2M DMSO + 1M Acetamide + 3M Propyleneglycol
Freezing method Vitrification
Mycoplasma/Acholeplasma (-)
Chromosome mode 46XX(20)
STR(human) OK
Images
deposit info
lot info
Relational File deposit infolot info
SDS_DAP(MEM)_Japanese.pdf
Reference information Reference 2
User's Publication 75


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Reference
4005  Kondo T, Imamura K, Funayama M, Tsukita K, Miyake M, Ohta A, Woltjen K, Nakagawa M, Asada T, Arai T, Kawakatsu S, Izumi Y, Kaji R, Iwata N, Inoue H.  iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid β Combination for Alzheimer's Disease.  Cell Rep  2017  21:2304-2312  PubMed ID: 29166618   DOI: 10.1016/j.celrep.2017.10.109
3676  Okita K1, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S.  A more efficient method to generate integration-free human iPS cells.  Nat Methods  2011  8(5):409-12  PubMed ID: 21460823   DOI: 10.1038/nmeth.1591

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User's Publication
21546  Kuroda T, Yasuda S, Matsuyama S, Miura T, Sawada R, Matsuyama A, Yamamoto Y, Morioka MS, Kawaji H, Kasukawa T, Itoh M, Akutsu H, Kawai J, Sato Y.  ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons.  Sci Rep  2024  14(1):690  PubMed ID: 38184695   DOI: 10.1038/s41598-023-51082-4
21673  Osaki T, Duenki T, Chow SYA, Ikegami Y, Beaubois R, Levi T, Nakagawa-Tamagawa N, Hirano Y, Ikeuchi Y.  Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons.  Nat Commun  2024  15(1):2945  PubMed ID: 38600094   DOI: 10.1038/s41467-024-46787-7
21811  Zenk F, Fleck JS, Jansen SMJ, Kashanian B, Eisinger B, Santel M, Dupré JS, Camp JG, Treutlein B.  Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems.  Nat Neurosci  2024    PubMed ID: 38914828   DOI: 10.1038/s41593-024-01652-0
21955  Tomuro K, Mito M, Toh H, Kawamoto N, Miyake T, Chow SYA, Doi M, Ikeuchi Y, Shichino Y, Iwasaki S.  Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts.  Nat Commun  2024  15(1):7061  PubMed ID: 39187487   DOI: 10.1038/s41467-024-51258-0
22087  Niwa R, Matsumoto T, Liu AY, Kawato M, Kondo T, Tsukita K, Gee P, Inoue H, Maurissen TL, Woltjen K.  Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells.  CRISPR J  2024  7(5):293-304  PubMed ID: 39436282   DOI: 10.1089/crispr.2024.0028
19744  Azuma N, Yokoi T, Tanaka T, Matsuzaka E, Saida Y, Nishina S, Terao M, Takada S, Fukami M, Okamura K, Maehara K, Yamasaki T, Hirayama J, Nishina H, Handa H, Yamaguchi Y.  Integrator complex subunit 15 controls mRNA splicing and is critical for eye development  Hum Mol Genet  2023  32(12):2032-2045  PubMed ID: 36851842   DOI: 10.1093/hmg/ddad034
19819  Zhang D, Eguchi N, Okazaki S, Sora I, Hishimoto A.  Telencephalon Organoids Derived from an Individual with ADHD Show Altered Neurodevelopment of Early Cortical Layer Structure  Stem Cell Rev Rep  2023  19(5):1482-1491  PubMed ID: 36872412   DOI: 10.1007/s12015-023-10519-z
17483  Nakatsu D, Kunishige R, Taguchi Y, Shinozaki-Narikawa N, Osaka K, Yokomizo K, Ishida M, Takei S, Yamasaki S, Hagiya K, Hattori K, Tsukamoto T, Murata M, Kano F.  BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions  Stem Cell Reports  2023  18(3):688-705  PubMed ID: 36764297   DOI: 10.1016/j.stemcr.2023.01.004
21125  Togo H, Terada K, Ujitsugu A, Hirose Y, Takeuchi H, Kusunoki M.  Fabrication Scaffold with High Dimensional Control for Spheroids with Undifferentiated iPS Cell Properties.  Cells  2023  12(2)  PubMed ID: 36672213   DOI: 10.3390/cells12020278
21170  Kawamata M, Suzuki HI, Kimura R, Suzuki A.  Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs.  Nat Biomed Eng  2023    PubMed ID: 37037965   DOI: 10.1038/s41551-023-01011-7
21329  Riesenberg S, Kanis P, Macak D, Wollny D, Düsterhöft D, Kowalewski J, Helmbrecht N, Maricic T, Pääbo S.  Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.  Nat Methods  2023    PubMed ID: 37474806   DOI: 10.1038/s41592-023-01949-1
21371  Bressan C, Snapyan M, Snapyan M, Klaus J, di Matteo F, Robertson SP, Treutlein B, Parent M, Cappello S, Saghatelyan A.  Metformin rescues migratory deficits of cells derived from patients with periventricular heterotopia.  EMBO Mol Med  2023  e16908  PubMed ID: 37609821   DOI: 10.15252/emmm.202216908
21439  Terada E, Bamba Y, Takagaki M, Kawabata S, Tachi T, Nakamura H, Nishida T, Kishima H.  Silicate Microfiber Scaffolds Support the Formation and Expansion of the Cortical Neuronal Layer of Cerebral Organoids With a Sheet-Like Configuration.  Stem Cells Transl Med  2023    PubMed ID: 37843388   DOI: 10.1093/stcltm/szad066
17541  He Z, Maynard A, Jain A, Gerber T, Petri R, Lin HC, Santel M, Ly K, Dupré JS, Sidow L, Sanchis Calleja F, Jansen SMJ, Riesenberg S, Camp JG, Treutlein B.  Lineage recording in human cerebral organoids  Nat Methods  2022  19(1):90-99  PubMed ID: 34969984   DOI: 10.1038/s41592-021-01344-8
17579  Hirata M, Ichiyanagi T, Katoh H, Hashimoto T, Suzuki H, Nitta H, Kawase M, Nakai R, Imamura M, Ichiyanagi K.  Sequence divergence and retrotransposon insertion underlie interspecific epigenetic differences in primates  Mol Biol Evol  2022  39(10):msac208  PubMed ID: 36219870   DOI: 10.1093/molbev/msac208
20238  Linda K, Lewerissa EI, Verboven AHA, Gabriele M, Frega M, Klein Gunnewiek TM, Devilee L, Ulferts E, Hommersom M, Oudakker A, Schoenmaker C, van Bokhoven H, Schubert D, Testa G, Koolen DA, de Vries BBA, Nadif Kasri N.  Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.  Autophagy  2022  1-20  PubMed ID: 34286667   DOI: 10.1080/15548627.2021.1936777
16702  Song D, Takahashi G, Zheng YW, Matsuo-Takasaki M, Li J, Takami M, An Y, Hemmi Y, Miharada N, Fujioka T, Noguchi M, Nakajima T, Saito MK, Nakamura Y, Oda T, Miyaoka Y, Hayashi Y.  Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes  Hum Mol Genet  2022  Apr 7;ddac080  PubMed ID: 35388883   DOI: 10.1093/hmg/ddac080
16844  Cruceanu C, Dony L, Krontira AC, Fischer DS, Roeh S, Di Giaimo R, Kyrousi C, Kaspar L, Arloth J, Czamara D, Gerstner N, Martinelli S, Wehner S, Breen MS, Koedel M, Sauer S, Sportelli V, Rex-Haffner M, Cappello S, Theis FJ, Binder EB.  Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study  Am J Psychiatry  2022  179(5):375-387  PubMed ID: 34698522   DOI: 10.1176/appi.ajp.2021.21010095
20851  Chow SYA, Nakayama K, Osaki T, Sugiyama M, Yamada M, Takeuchi H, Ikeuchi Y.  Human sensory neurons modulate melanocytes through secretion of RGMB.  Cell Rep  2022  40(12):111366  PubMed ID: 36130522   DOI: 10.1016/j.celrep.2022.111366
20875  Okawa R, Sogawa K, Shiozaki M, Yachiku K, Miura T, Shibata T, Ezoe S.  The effects of continuous exposure to low-dose chlorine dioxide gas on the characteristics of induced pluripotent stem cells.  Regen Ther  2022  21:250-257  PubMed ID: 36092508   DOI: 10.1016/j.reth.2022.07.014
20878  Fleck JS, Jansen SMJ, Wollny D, Zenk F, Seimiya M, Jain A, Okamoto R, Santel M, He Z, Camp JG, Treutlein B.  Inferring and perturbing cell fate regulomes in human brain organoids.  Nature  2022    PubMed ID: 36198796   DOI: 10.1038/s41586-022-05279-8
20936  Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S.  A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.  Med (N Y)  2022    PubMed ID: 36395757   DOI: 10.1016/j.medj.2022.10.003
18217  Polla DL, Farazi Fard MA, Tabatabaei Z, Habibzadeh P, Levchenko OA, Nikuei P, Makrythanasis P, Hussain M, von Hardenberg S, Zeinali S, Fallah MS, Schuurs-Hoeijmakers JHM, Shahzad M, Fatima F, Fatima N, Kaat LD, Bruggenwirth HT, Fleming LR, Condie J, Ploski R, Pollak A, Pilch J, Demina NA, Chukhrova AL, Sergeeva VS, Venselaar H, Masri AT, Hamamy H, Santoni FA, Linda K, Ahmed ZM, Nadif Kasri N, de Brouwer APM, Bergmann AK, Hethey S, Yavarian M, Ansar M, Riazuddin S, Riazuddin S, Silawi M, Ruggeri G, Pirozzi F, Eftekhar E, Taghipour Sheshdeh A, Bahramjahan S, Mirzaa GM, Lavrov AV, Antonarakis SE, Faghihi MA, van Bokhoven H.  Biallelic variants in TMEM222 cause a new autosomal recessive neurodevelopmental disorder  Genet Med  2021  23(7):1246-1254  PubMed ID: 33824500   DOI: 10.1038/s41436-021-01133-w
13380  Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y.  Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.  FEBS Open Bio  2021  11(2):354-366  PubMed ID: 33301617   DOI: 10.1002/2211-5463.13060
20014  Matsuo M, Nadanaka S, Soga M, Sugiyama T, Serigano S, Shimano K, Ichinose F, Nakamura T, Maeda T, Houkin K, Era T, Kitagawa H.  Vulnerability to shear stress caused by altered peri-endothelial matrix is a key feature of Moyamoya disease.  Sci Rep  2021  11(1):1552  PubMed ID: 33452387   DOI: 10.1038/s41598-021-81282-9
20221  Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, Kawamura Y, Ueda Y, Takai H, Mandai M, Kondoh E.  Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells  Sci Rep  2021  11(1):14167  PubMed ID: 34239021   DOI: 10.1038/s41598-021-93766-9
20257  Lin HC, He Z, Ebert S, Schörnig M, Santel M, Nikolova MT, Weigert A, Hevers W, Kasri NN, Taverna E, Camp JG, Treutlein B.  NGN2 induces diverse neuron types from human pluripotency.  Stem Cell Reports  2021    PubMed ID: 34358451   DOI: 10.1016/j.stemcr.2021.07.006
15507  Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T.  Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells  Nat Protoc  2021  16(2):919-936  PubMed ID: 33432231   DOI: 10.1038/s41596-020-00441-w
15523  Abe T, Uosaki H, Shibata H, Hara H, Sarentonglaga B, Nagao Y, Hanazono Y.  Fetal sheep support the development of hematopoietic cells in vivo from human induced pluripotent stem cells  Exp Hematol   2021  95:46-57.e8  PubMed ID: 33395577   DOI: 10.1016/j.exphem.2020.12.006
20366  Hisatsune C, Shimada T, Miyamoto A, Lee A, Yamagata K.  Tuberous Sclerosis Complex (TSC) Inactivation Increases Neuronal Network Activity by Enhancing Ca2+ Influx via L-Type Ca2+ Channels.  J Neurosci  2021  41(39):8134-8149  PubMed ID: 34417327   DOI: 10.1523/JNEUROSCI.1930-20.2021
15683  Vita Stepanova, Kaja Ewa Moczulska, Guido N Vacano, Ilia Kurochkin, Xiangchun Ju, Stephan Riesenberg, Dominik Macak, Tomislav Maricic, Linda Dombrowski, Maria Schörnig, Konstantinos Anastassiadis, Oliver Baker, Ronald Naumann, Ekaterina Khrameeva, Anna Vanushkina, Elena Stekolshchikova, Alina Egorova, Anna Tkachev, Randall Mazzarino, Nathan Duval, Dmitri Zubkov, Patrick Giavalisco, Terry G Wilkinson, David Patterson, Philipp Khaitovich, Svante Pääbo  Reduced purine biosynthesis in humans after their divergence from Neandertals  eLife  2021  10:2021-5-4  PubMed ID: 33942714   DOI: 10.7554/elife.58741
15899  Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T.  eIF2B-capturing viral protein NSs suppresses the integrated stress response  Nat Commun  2021  12(1):7102  PubMed ID: 34876589   DOI: 10.1038/s41467-021-27337-x
20491  Tadokoro S, Tokuyama-Toda R, Tatehara S, Ide S, Umeki H, Miyoshi K, Noma T, Satomura K.  A New Induction Method for the Controlled Differentiation of Human-Induced Pluripotent Stem Cells Using Frozen Sections.  Cells  2021  10(11)  PubMed ID: 34831050   DOI: 10.3390/cells10112827
6879  Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H.  Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells.  Cell Rep  2020  30(1):18-24  PubMed ID: 31914385   DOI: 10.1016/j.celrep.2019.12.009
10143  Tomoyo Sawada, Thomas E Chater, Yohei Sasagawa, Mika Yoshimura, Noriko Fujimori-Tonou, Kaori Tanaka, Kynon J M Benjamin, Apuã C M Paquola, Jennifer A Erwin, Yukiko Goda, Itoshi Nikaido, Tadafumi Kato  Developmental excitation-inhibition imbalance underlying psychoses revealed by single-cell analyses of discordant twins-derived cerebral organoids  Mol Psychiatry  2020  25(11):2695-2711  PubMed ID: 32764691   DOI: 10.1038/s41380-020-0844-z
11989  Dayem AA, Won J, Goo HG, Yang GM, Seo DS, Jeon BM, Choi HY, Park SE, Lim KM, Jang SH, Lee SB, Choi SB, Kim K, Kang GH, Yeon GB, Kim DS, Cho SG.  The immobilization of fibronectin- and fibroblast growth factor 2-derived peptides on a culture plate supports the attachment and proliferation of human pluripotent stem cells.  Stem Cell Res  2020    PubMed ID: 31981882   DOI: 10.1016/j.scr.2020.101700
13010  Misawa R, Minami T, Okamoto A, Ikeuchi Y.  A Light-Inducible Hedgehog Signaling Activator Modulates Proliferation and Differentiation of Neural Cells.  ACS Chem Biol  2020    PubMed ID: 32343549   DOI: 10.1021/acschembio.0c00195
13064  Maurissen TL, Woltjen K.  Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation.  Nat Commun  2020    PubMed ID: 32513994   DOI: 10.1038/s41467-020-16643-5
13174  Yokouchi Y, Suzuki S, Ohtsuki N, Yamamoto K, Noguchi S, Soejima Y, Goto M, Ishioka K, Nakamura I, Suzuki S, Takenoshita S, Era T.  Rapid repair of human disease-specific single-nucleotide variants by One-SHOT genome editing.  Sci Rep  2020    PubMed ID: 32811847   DOI: 10.1038/s41598-020-70401-7
13381  Sim H, Seo JH, Kim J, Oh M, Lee JE, Baek A, Lee SY, Chung SK, Son MY, Chae JI, Jeon YJ, Kim J.  Quantitative Proteomic Analysis of Primitive Neural Stem Cells from LRRK2 G2019S-Associated Parkinson's Disease Patient-Derived iPSCs.  Life (Basel)  2020    PubMed ID: 33297425   DOI: 10.3390/life10120331
14062  Ayo-Martin AC, Kyrousi C, Di Giaimo R, Cappello S.  GNG5 Controls the Number of Apical and Basal Progenitors and Alters Neuronal Migration During Cortical Development  Front Mol Biosci  2020  578137.  PubMed ID: 33330619   DOI: 10.3389/fmolb.2020.578137
14943  Krieger TG, Tirier SM, Park J, Jechow K, Eisemann T, Peterziel H, Angel P, Eils R, Conrad C.  Modeling glioblastoma invasion using human brain organoids and single-cell transcriptomics  Neuro Oncol  2020  22(8):1138-1149  PubMed ID: 32297954   DOI: 10.1093/neuonc/noaa091
16212  Kotaro Tsuboyama, Tatsuya Osaki, Eriko Matsuura-Suzuki, Hiroko Kozuka-Hata, Yuki Okada, Masaaki Oyama, Yoshiho Ikeuchi, Shintaro Iwasaki, Yukihide Tomari  A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation  PLoS Biol  2020  18(3):e3000632  PubMed ID: 32163402   DOI: 10.1371/journal.pbio.3000632
16885  Osman A, Oze M, Afify SM, Hassan G, El-Ghlban S, Nawara HM, Fu X, Zahra MH, Seno A, Winer I, Salomon DS, Seno M.  Tumor-associated macrophages derived from cancer stem cells  Acta Histochem  2020  122(8):151628  PubMed ID: 32992123   DOI: 10.1016/j.acthis.2020.151628
11304  Ueda M, Hashimoto Y, Honda Y, Baba S, Morita S.  Comparison of the characteristics of mesenchymal stem-like cells derived by integration-free induced pluripotent stem cells in different single-cell culture media under feeder-free conditions.  Med Mol Morphol  2019    PubMed ID: 30446810   DOI: 10.1007/s00795-018-0211-1
4572  Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, Miura T, Matsuyama A, Sato Y.  SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.  Nat Commun  2019  10(1):2175  PubMed ID: 31092818   DOI: 10.1038/s41467-019-09511-4
5346  Kirihara T, Luo Z, Chow SYA, Misawa R, Kawada J, Shibata S, Khoyratee F, Vollette CA, Volz V, Levi T, Fujii T, Ikeuchi Y.  A Human Induced Pluripotent Stem Cell-Derived Tissue Model of a Cerebral Tract Connecting Two Cortical Regions.  iScience  2019  14:301-311  PubMed ID: 31006610   DOI: 10.1016/j.isci.2019.03.012
11576  Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y, Tomonaga K.  RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs.  Mol Ther Methods Clin Dev  2019  14:47-55  PubMed ID: 31309127   DOI: 10.1016/j.omtm.2019.05.010
11589  Aoki H, Yamashita M, Hashita T, Nakayama M, Yagi M, Iwao T, Matsunaga T.  Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures.  Biochem. Biophys. Res. Commun.  2019  515(4):672-678  PubMed ID: 31178142   DOI: 10.1016/j.bbrc.2019.05.179
11744  Riesenberg S, Chintalapati M, Macak D, Kanis P, Maricic T, Pääbo S.  Simultaneous precise editing of multiple genes in human cells.  Nucleic Acids Res.  2019    PubMed ID: 31392986   DOI: 10.1093/nar/gkz669
11860  Kanton S, Boyle MJ, He Z, Santel M, Weigert A, Sanchís-Calleja F, Guijarro P, Sidow L, Fleck JS, Han D, Qian Z, Heide M, Huttner WB, Khaitovich P, Pääbo S, Treutlein B, Camp JG.  Organoid single-cell genomic atlas uncovers human-specific features of brain development.  Nature  2019    PubMed ID: 31619793   DOI: 10.1038/s41586-019-1654-9
10578  Yuki Maeda, Keiichi Motoyama, Taishi Higashi, Risako Onodera, Toru Takeo, Naomi Nakagata, Yuki Kurauchi, Hiroshi Katsuki, Yoichi Ishitsuka, Yuki Kondo, Tetsumi Irie, Takumi Era, Hidetoshi Arima  Lowering effect of dimethyl-α-cyclodextrin on GM1-ganglioside accumulation in GM1-gangliosidosis model cells and in brain of β-galactosidase-knockout mice  Journal of Inclusion Phenomena and Macrocyclic Chemistry  2019  93:53–66    DOI: 10.1007/s10847-018-0835-8
12368  Kimura Y, Shofuda T, Higuchi Y, Nagamori I, Oda M, Nakamori M, Onodera M, Kanematsu D, Yamamoto A, Katsuma A, Suemizu H, Nakano T, Kanemura Y, Mochizuki H.  Human Genomic Safe Harbors and the Suicide Gene-Based Safeguard System for iPSC-Based Cell Therapy  Stem Cells Transl Med  2019  8(7):627-638  PubMed ID: 30887735   DOI: 10.1002/sctm.18-0039
7001  Akiyama T, Sato S, Chikazawa-Nohtomi N, Soma A, Kimura H, Wakabayashi S, Ko SBH, Ko MSH.  Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.  Sci Rep  2018  8:1189  PubMed ID: 29352121   DOI: 10.1038/s41598-017-19114-y
10463  Sato-Nishiuchi R, Li S, Ebisu F, Sekiguchi K.  Recombinant laminin fragments endowed with collagen-binding activity: A tool for conferring laminin-like cell-adhesive activity to collagen matrices.  Matrix Biol.  2018  65:75-90  PubMed ID: 28801205   DOI: 10.1016/j.matbio.2017.08.001
11234  Yasuda S, Kusakawa S, Kuroda T, Miura T, Tano K, Takada N, Matsuyama S, Matsuyama A, Nasu M, Umezawa A, Hayakawa T, Tsutsumi H, Sato Y.  Tumorigenicity-associated characteristics of human iPS cell lines.  PLoS ONE  2018    PubMed ID: 30286143   DOI: 10.1371/journal.pone.0205022
4124  Ikeda K, Kawasaki Y, Matsuda H, Kishida S, Iwasaki A, Ohata S, Urashima Y, Hirotani Y.  Approach for differentiating trophoblast cell lineage from human induced pluripotent stem cells with retinoic acid in the absence of bone morphogenetic protein 4.  Placenta  2018    PubMed ID: 30415744   DOI: 10.1016/j.placenta.2018.10.001
5348  Yoshinori Hasegawa, Masashi Ikeno, Nobutaka Suzuki, Manabu Nakayama, Osamu Ohara  Improving the efficiency of gene insertion in a human artificial chromosome vector and its transfer in human-induced pluripotent stem cells  Biology Methods and Protocols  2018  1–10  PubMed ID: 32161806   DOI: 10.1093/biomethods/bpy013
7009  Yokoi T, Tanaka T, Matsuzaka E, Tamalu F, Watanabe SI, Nishina S, Azuma N.  Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells.  Sci Rep  2017  7:16757  PubMed ID: 29196712   DOI: 10.1038/s41598-017-16727-1
7015  Kawada J, Kaneda S, Kirihara T, Maroof A, Levi T, Eggan K, Fujii T, Ikeuchi Y.  Generation of a Motor Nerve Organoid with Human Stem Cell-Derived Neurons.  Stem Cell Reports  2017  9:1441-1449  PubMed ID: 29107592   DOI: 10.1016/j.stemcr.2017.09.021
7026  Koui Y, Kido T, Ito T, Oyama H, Chen SW, Katou Y, Shirahige K, Miyajima A.  An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells.  Stem Cell Reports  2017  9:490-498  PubMed ID: 28757162   DOI: 10.1016/j.stemcr.2017.06.010
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