細胞番号 : 細胞名 HMS : Human mesenchymal stem cells  update : 2021/12/16
細胞特性(Comment:英)
細胞特性(日)		研究用ヒト間葉系幹細胞 (HMS))
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)
使用条件(日)
備考(英)
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提供申込書類(英)
		Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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文献情報	Reference(英)	2件
	Reference(日)	0件
	利用者成果(英)	40件
	利用者成果(日)	1件

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Reference(英)

7754  Numasawa Y, Kimura T, Miyoshi S, Nishiyama N, Hida N, Tsuji H, Tsuruta H, Segawa K, Ogawa S, Umezawa A.  Treatment of human mesenchymal stem cells with angiotensin receptor blocker improved efficiency of cardiomyogenic transdifferentiation and improved cardiac function via angiogenesis.  Stem Cells  2011  29:1405-14  PubMed ID: 21755575   DOI: 10.1002/stem.691

3611  Tsutsumi S, Shimazu A, Miyazaki K, Pan H, Koike C, Yoshida E, Takagishi K, Kato Y.  Retention of multilineage differentiation potential of mesenchymal cells during proliferation in response to FGF.  Biochem Biophys Res Commun  2001  288(2):413-9  PubMed ID: 11606058   DOI: 10.1006/bbrc.2001.5777

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利用者成果(英)

19713  Kiyota M, Iwata T, Hasegawa N, Sasaki S, Taniguchi Y, Hamamoto Y, Matsuda S, Ouhara K, Takeda K, Fujita T, Kurihara H, Kawaguchi H, Mizuno N.  Periodontal tissue regeneration with cementogenesis after application of brain-derived neurotrophic factor in 3-wall inflamed intra-bony defect  J Periodontal Res  2024    PubMed ID: 38501357   DOI: 10.1111/jre.13244

19736  Hirata R, Iwata T, Fujita T, Nagahara T, Matsuda S, Sasaki S, Taniguchi Y, Hamamoto Y, Ouhara K, Kudo Y, Kurihara H, Mizuno N.  Periostin regulates integrin expression in gingival epithelial cells  J Oral Biosci  2024  66(1):170-178  PubMed ID: 38048847   DOI: 10.1016/j.job.2023.11.009

19621  Cheng Tan, Yuki Teranishi, Kenzo Morinaga and *Yoshiya Hashimoto  Bone formation with a collagen model polypeptides/alpha­tricalcium phosphate sponge in a mandibular canine defect model  J Osaka Dent Univ  2023  57(2):223−231    DOI: 10.18905/jodu.57.2_223

19712  Iwata T, Kaneda-Ikeda E, Takahashi K, Takeda K, Nagahara T, Kajiya M, Sasaki S, Ishida S, Yoshioka M, Matsuda S, Ouhara K, Fujita T, Kurihara H, Mizuno N.  Regulation of osteogenesis in bone marrow-derived mesenchymal stem cells via histone deacetylase 1 and 2 co-cultured with human gingival fibroblasts and periodontal ligament cells  J Periodontal Res  2023  58(1):83-96  PubMed ID: 36346011   DOI: 10.1111/jre.13070

16063  Iwata T, Mizuno N, Nagahara T, Kaneda-Ikeda E, Kajiya M, Sasaki S, Takeda K, Kiyota M, Yagi R, Fujita T, Kurihara H.  Cytokines regulate stemness of mesenchymal stem cells via miR-628-5p during periodontal regeneration  J Periodontol  2022  Jun 21  PubMed ID: 34152611   DOI: 10.1002/JPER.21-0064

20692  Hayashi Y, Kawabata KC, Tanaka Y, Uehara Y, Mabuchi Y, Murakami K, Nishiyama A, Kiryu S, Yoshioka Y, Ota Y, Sugiyama T, Mikami K, Tamura M, Fukushima T, Asada S, Takeda R, Kunisaki Y, Fukuyama T, Yokoyama K, Uchida T, Hagihara M, Ohno N, Usuki K, Tojo A, Katayama Y, Goyama S, Arai F, Tamura T, Nagasawa T, Ochiya T, Inoue D, Kitamura T.  MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.  Cell Rep  2022  39(6):110805  PubMed ID: 35545056   DOI: 10.1016/j.celrep.2022.110805

20708  Ogawa T, Kajiya M, Horikoshi S, Yoshii H, Yoshino M, Motoike S, Morimoto S, Sone H, Iwata T, Ouhara K, Matsuda S, Mizuno N.  Xenotransplantation of cryopreserved human clumps of mesenchymal stem cells/extracellular matrix complexes pretreated with IFN-γ induces rat calvarial bone regeneration.  Regen Ther  2022  20:117-125  PubMed ID: 35582709   DOI: 10.1016/j.reth.2022.04.003

14521  Nagasaki K, Nakashima A, Tamura R, Ishiuchi N, Honda K, Ueno T, Doi S, Kato Y, Masaki T.  Mesenchymal stem cells cultured in serum-free medium ameliorate experimental peritoneal fibrosis  Stem Cell Res Ther  2021  12(1):203  PubMed ID: 33757592   DOI: 10.1186/s13287-021-02273-1

14790  Yamada Y, Nakashima A, Doi S, Ishiuchi N, Kanai R, Miyasako K, Masaki T.  Localization and Maintenance of Engrafted Mesenchymal Stem Cells Administered via Renal Artery in Kidneys with Ischemia-Reperfusion Injury  Int J Mol Sci  2021  22(8):4178  PubMed ID: 33920714   DOI: 10.3390/ijms22084178

15506  Kim J, Adachi T.  Cell-fate decision of mesenchymal stem cells toward osteocyte differentiation is committed by spheroid culture  Sci Rep  2021  11(1):13204  PubMed ID: 34168224   DOI: 10.1038/s41598-021-92607-z

16061  Iwata T, Mizuno N, Ishida S, Kajiya M, Nagahara T, Kaneda-Ikeda E, Yoshioka M, Munenaga S, Ouhara K, Fujita T, Kawaguchi H, Kurihara H.  Functional Regulatory Mechanisms Underlying Bone Marrow Mesenchymal Stem Cell Senescence During Cell Passages  Cell Biochem Biophys  2021  79(2):321-336  PubMed ID: 33559812   DOI: 10.1007/s12013-021-00969-y

9827  Eri Kaneda-Ikeda, Tomoyuki Iwata, Noriyoshi Mizuno, Takayoshi Nagahara, Mikihito Kajiya, Kazuhisa Ouhara, Minami Yoshioka, Shu Ishida, Hiroyuki Kawaguchi, Hidemi Kurihara  Regulation of Osteogenesis via miR-101-3p in Mesenchymal Stem Cells by Human Gingival Fibroblasts  J Bone Miner Metab  2020  38:442-455  PubMed ID: 31970478   DOI: 10.1007/s00774-019-01080-2

9869  Naoki Ishiuchi, Ayumu Nakashima, Shigehiro Doi, Ken Yoshida, Satoshi Maeda, Ryo Kanai, Yumi Yamada, Takeshi Ike, Toshiki Doi, Yukio Kato, Takao Masaki   Hypoxia-preconditioned Mesenchymal Stem Cells Prevent Renal Fibrosis and Inflammation in Ischemia-Reperfusion Rats  Stem Cell Res Ther  2020  11(1):130  PubMed ID: 32197638   DOI: 10.1186/s13287-020-01642-6

13114  Matsumura K, Hatakeyama S, Naka T, Ueda H, Rajan R, Tanaka D, Hyon SH.  Molecular Design of Polyampholytes for Vitrification-Induced Preservation of Three-Dimensional Cell Constructs without Using Liquid Nitrogen.  Biomacromolecules  2020    PubMed ID: 32659086   DOI: 10.1021/acs.biomac.0c00293

13909  Komatsu N, Kajiya M, Morimoto S, Motoike S, Yoshii H, Iwata T, Ouhara K, Matsuda S, Mizuno N, Kurihara H.  Cox2-mediated PGE2 production via p38/JNK-c-fos signaling inhibits cell apoptosis in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes  Biochem Biophys Res Commun  2020  530(2):448-454  PubMed ID: 32553627   DOI: 10.1016/j.bbrc.2020.05.100

10749  Morita Y, Yamashita T, Toku T, Ju Y.  Optimization of differentiation time of mesenchymal-stem-cell to tenocyte under a cyclic stretching with a microgrooved culture membrane and selected measurement cells.  Acta Bioeng Biomech  2018  20:3-10  PubMed ID: 29658516

10777  Saito S, Hiemori K, Kiyoi K, Tateno H.  Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray.  Sci Rep  2018  8:3997  PubMed ID: 29507392   DOI: 10.1038/s41598-018-22450-2

11108  Kakutani H, Yuzuriha T, Akiyama E, Nakao T, Ohta S.  Complex toxicity as disruption of adipocyte or osteoblast differentiation in human mesenchymal stem cells under the mixed condition of TBBPA and TCDD.  Toxicol Rep  2018  5:737-743  PubMed ID: 29928592   DOI: 10.1016/j.toxrep.2018.06.007

4507  Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T.  Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis.  Stem Cells Transl Med  2018  7(12):893-905  PubMed ID: 30269426   DOI: 10.1002/sctm.17-0284

4509  Azizah Pangesty, Mitsugu Todo  Development of cylindrical microfibrous scaffold using melt-spinning method for vascular tissue engineering  Materials Letters  2018  228, 34-338    DOI: 10.1016/j.matlet.2018.06.046

4511  Hashimoto Y, Ueda M, Kohiga Y, Imura K, Hontsu S.  Application of fluoridated hydroxyapatite thin film coatings using KrF pulsed laser deposition.  Dent Mater J  2018  37(3):408-413  PubMed ID: 29279546   DOI: 10.4012/dmj.2017-122

4512  Qi P, Ohba S, Hara Y, Fuke M, Ogawa T, Ohta S, Ito T.  Fabrication of calcium phosphate-loaded carboxymethyl cellulose non-woven sheets for bone regeneration.  Carbohydr Polym  2018  189:322-330  PubMed ID: 29580416   DOI: 10.1016/j.carbpol.2018.02.050

4513  Kunimatsu R, Awada T, Yoshimi Y, Ando K, Hirose N, Tanne Y, Sumi K, Tanimoto K.  The C-terminus of the amelogenin peptide influences the proliferation of human bone marrow mesenchymal stem cells.  J. Periodontol.  2018  89(4):496-505  PubMed ID: 29683502   DOI: 10.1002/JPER.17-0087

14054  Yamaguchi S, Horie N, Satoh K, Ishikawa T, Mori T, Maeda H, Fukuda Y, Ishizaka S, Hiu T, Morofuji Y, Izumo T, Nishida N, Matsuo T.  Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke  J Cereb Blood Flow Metab  2018  38(7):1199-1212  PubMed ID: 28914133   DOI: 10.1177/0271678X17731964

10287  Takeshita K, Motoike S, Kajiya M, Komatsu N, Takewaki M, Ouhara K, Iwata T, Takeda K, Mizuno N, Fujita T, Kurihara H.  Xenotransplantation of interferon-gamma-pretreated clumps of a human mesenchymal stem cell/extracellular matrix complex induces mouse calvarial bone regeneration.  Stem Cell Res Ther  2017  8:101  PubMed ID: 28446226   DOI: 10.1186/s13287-017-0550-1

12223  Di He, Yoshinori Arisaka, Kenichi Masuda, Mitsuya Yamamoto, Naoya Takeda  A photoresponsive soft interface reversibly controls wettability and cell adhesion by conformational changes in a spiropyran-conjugated amphiphilic block copolymer  Acta Biomater  2017  15;51:101-111  PubMed ID: 28110068   DOI: 10.1016/j.actbio.2017.01.049

10868    Cryopreservation of a Two-Dimensional Monolayer Using a Slow Vitrification Method with Polyampholyte to Inhibit Ice Crystal Formation  ACS Biomater. Sci. Eng.  2016  2(6):1023-1029  PubMed ID: 33429511   DOI: 10.1021/acsbiomaterials.6b00150

4385  Tateno H, Saito S, Hiemori K, Kiyoi K, Hasehira K, Toyoda M, Onuma Y, Ito Y, Akutsu H, Hirabayashi J.  α2-6 sialylation is a marker of the differentiation potential of human mesenchymal stem cells.  Glycobiology  2016  26(12):1328-1337  PubMed ID: 27038486   DOI: 10.1093/glycob/cww039

12921  Arisaka Y, Nishijima Y, Yusa S, Takeda N.  Photo-induced in situ crosslinking of polymer brushes with dimethyl maleimide moieties for dynamically stimulating stem cell differentiation  J Biomater Sci Polym Ed  2016  27(13):1331-40  PubMed ID: 27255343   DOI: 10.1080/09205063.2016.1196531

14184  Sasamoto T, Fujimoto K, Kanawa M, Kimura J, Takeuchi J, Harada N, Goto N, Kawamoto T, Noshiro M, Suardita K, Tanne K, Kato Y.  DEC2 is a negative regulator for the proliferation and differentiation of chondrocyte lineage-committed mesenchymal stem cells  Int J Mol Med  2016  38(3):876-84  PubMed ID: 27430159   DOI: 10.3892/ijmm.2016.2660

14975  Yamanaka K, Yamamoto K, Sakai Y, Suda Y, Shigemitsu Y, Kaneko T, Kato K, Kumagai T, Kato Y.  Seeding of mesenchymal stem cells into inner part of interconnected porous biodegradable scaffold by a new method with a filter paper  Dent Mater J  2015  34(1):78-85  PubMed ID: 25748462   DOI: 10.4012/dmj.2013-330

14993  Hashimoto Y, Nishikawa H, Kusunoki M, Li P, Hontsu S.  A novel membrane-type apatite scaffold engineered by pulsed laser ablation  Dent Mater J  2015  34(3):345-50  PubMed ID: 25904175   DOI: 10.4012/dmj.2014-299

3381  S Kumabe, M Nakatsuka, R Iwai, K Ueda, Y Matsuda, S Morita, Y Iwai  A fine structure study on osteogenesis of mesenchymal stem cells cultured with a 3D collagen scaffold.  Integrative Molecular Medicine  2015  2:115-120    DOI: 10.15761/IMM.1000123

10292  Baiyao Xu, Yang Ju, Guanbin Song  Role of p38, ERK1/2, Focal Adhesion Kinase, RhoA/ROCK and Cytoskeleton in the Adipogenesis of Human Mesenchymal Stem Cells  J Biosci Bioeng  2014  117(5):624-31  PubMed ID: 24331979   DOI: 10.1016/j.jbiosc.2013.10.018

15917  Ono M, Kosaka N, Tominaga N, Yoshioka Y, Takeshita F, Takahashi RU, Yoshida M, Tsuda H, Tamura K, Ochiya T.  Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells  Sci Signal   2014  7(332):ra63  PubMed ID: 24985346   DOI: 10.1126/scisignal.2005231

17087  Morishita A, Kumabe S, Nakatsuka M, Iwai Y.  A histological study of mineralised tissue formation around implants with 3D culture of HMS0014 cells in Cellmatrix Type I-A collagen gel scaffold in vitro  Okajimas Folia Anat Jpn  2014  91(3):57-71  PubMed ID: 25797459   DOI: 10.2535/ofaj.91.57

5997  Matsumura K, Hayashi F, Nagashima T, Hyon SH.  Long-term cryopreservation of human mesenchymal stem cells using carboxylated poly-l-lysine without the addition of proteins or dimethyl sulfoxide.  J Biomater Sci Polym Ed  2013  24(12):1484-97  PubMed ID: 23829460   DOI: 10.1080/09205063.2013.771318

18247  Sato F, Sato H, Jin D, Bhawal UK, Wu Y, Noshiro M, Kawamoto T, Fujimoto K, Seino H, Morohashi S, Kato Y, Kijima H.  Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver  Biochem Biophys Res Commun  2012  419(2):441-6  PubMed ID: 22382019   DOI: 10.1016/j.bbrc.2012.02.076

8472  Mizuno D, Agata H, Furue H, Kimura A, Narita Y, Watanabe N, Ishii Y, Ueda M, Tojo A, Kagami H.  Limited but heterogeneous osteogenic response of human bone marrow mesenchymal stem cells to bone morphogenetic protein-2 and serum.  Growth Factors  2010  28:34-43  PubMed ID: 19835486   DOI: 10.3109/08977190903326362

8177  Seita ADACHI, Yoshiya HASHIMOTO, Masaaki NAKAMURA  Effect of S100A4 siRNA on Genes Related to Osteogenic Differentiation in Human Mesenchymal Stem Cells  Journal of Oral Tissue Engineering  2009  6:140-151    DOI: 10.11223/jarde.6.140

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利用者成果(日)

8689  伊澤 俊次, 山路 公造, 星加 知宏, 中田 貴, 神農 泰生, 西谷 佳浩, 吉山 昌宏  ヒト骨髄間葉系幹細胞を用いた象牙芽細胞分化と象牙質再生  日本再生歯科医学会誌  2009  7:47-55    DOI: 10.11223/jard.7.47