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Cell No. : Cell Name
APS0001 : iPS-MEF-Ng-20D-17  update : 2024/11/11
CommentMouse induced pluripotent stem (iPS) cell line. Expressing GFP by Nanog promoter.Please see CiRA Foundation, if you are a researcher at a for-profit organization.
Comment from the depositor
Terms and conditions1) The RECIPIENT belongs to a not-for-profit academic organization (i.e., a university or another institution of higher education or any nonprofit scientific or educational organization, including government agencies). 2) Attach Appendix to MTA.
Remarks
Order Form Order Form(C-0033.pdf)   MTA(C-0007.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor https://www.cira.kyoto-u.ac.jp/
Originator Yamanaka, Shinya
Year of deposit 2007
Another name RCB2698
Animal _mouse < Mammals
Gender Male
Age at sampling embryo
Tissue embryonic fibroblast
Classification iPS
Recombinant recombinant
Exogene pMXs, Oct3/4, Sox2, Klf4, c-Myc, Nanog-GFP-IRES-Puro^r
Lifespan infinite
Morphology ES-like
Cellosaurus(Expasy) CVCL_T787
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (high glucose, without Sodium Pyruvate) + 15% FBS + 0.1mM NEAA + 0.1mM 2-Mercaptoethanol + 1000U/ml mouse LIF
Antibiotics Free
Passage method 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
Coating dish 0.1% gelatin coated dish
Culture information Passage cell No 2 x 10 6 cells/100 mm dish
SC frequency Subculture : once/2-3 days, Medium Renewal : every day
Temperature 37 ℃
CO2 concentration 5 %
Feeder cells MEF
Feeder treatment X-rays 5000R (or MMC)
Feeder seed cells 1-2 x 10 6 cells/100 mm dish
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Mycoplasma (-)
Animal PCR OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 144


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Reference
3672  Okita K, Ichisaka T, Yamanaka S.  Generation of germline-competent induced pluripotent stem cells.  Nature.  2007  448(7151):313-7  PubMed ID: 17554338   DOI: 10.1038/nature05934

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User's Publication
21653  Yamaguchi T, Adachi Y, Tanida T, Taguchi K, Oka Y, Yoshida T, Kim WC, Takahashi K, Tanaka M.  Detection of biomagnetic signals from induced pluripotent stem cell-derived cardiomyocytes using deep learning with simulation data.  Sci Rep  2024  14(1):7296  PubMed ID: 38538741   DOI: 10.1038/s41598-024-58010-0
19622  Dastouri M, Ozdag H, Akar AR, Can A.  Differentiation and molecular characterization of endothelial progenitor and vascular smooth muscle cells from induced pluripotent stem cells  Bioimpacts  2023  13(4):289-300  PubMed ID: 37645025   DOI: 10.34172/bi.2022.24132
19801  Ishioka M, Nihashi Y, Sunagawa Y, Umezawa K, Shimosato T, Kagami H, Morimoto T, Takaya T.  Myogenetic Oligodeoxynucleotide Induces Myocardial Differentiation of Murine Pluripotent Stem Cells  Int J Mol Sci  2023  24(18):14380  PubMed ID: 37762684   DOI: 10.3390/ijms241814380
19857  Khoo CSM, Henmi T, Saito M.  Comparative Study of Metastasis Suppression Effects of Extracellular Vesicles Derived from Anaplastic Cell Lines, Nanog-Overexpressing Melanoma, and Induced Pluripotent Stem Cells  Int J Mol Sci  2023  24(24):17206  PubMed ID: 38139035   DOI: 10.3390/ijms242417206
19935  Hisashi Yano, Takashi Inoue, Satoshi Murakami, Hiroyuki Kaneko  The Effect of Oxygen Tension on the Differentiation of Outgrowth Cells from Embryoid Bodies Produced by Mouse Induced Pluripotent Stem Cells  Applied Sciences  2023  13:1215    DOI: 10.3390/app13021215
21356  Afify SM, Hassan G, Zahra MH, Nawara HM, Abu Quora HA, Osman A, Mansour H, Kumon K, Seno A, Chen L, Satoh A, Salomon DS, Seno M.  Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ.  Biomaterials  2023  301:122249  PubMed ID: 37506511   DOI: 10.1016/j.biomaterials.2023.122249
17635  Xu Y, Afify SM, Du J, Liu B, Hassan G, Wang Q, Li H, Liu Y, Fu X, Zhu Z, Chen L, Seno M.  The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells  Sci Rep  2022  12(1):347  PubMed ID: 35013447   DOI: 10.1038/s41598-021-04265-w
17639  Monzur S, Hassan G, Afify SM, Kumon K, Mansour H, Nawara HM, Sheta M, Abu Quora HA, Zahra MH, Xu Y, Fu X, Seno A, Wikström P, Szekeres FLM, Seno M.  Diphenyleneiodonium efficiently inhibits the characteristics of a cancer stem cell model derived from induced pluripotent stem cells  Cell Biochem Funct  2022  40(3):310-320  PubMed ID: 35285948   DOI: 10.1002/cbf.3696
20538  Hassan G, Ohara T, Afify SM, Kumon K, Zahra MH, Fu X, Al Kadi M, Seno A, Salomon DS, Seno M.  Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.  J Exp Clin Cancer Res  2022  41(1):29  PubMed ID: 35063003   DOI: 10.1186/s13046-021-02167-3
20575  Hassan G, Zahra MH, Seno A, Seno M.  The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.  Sci Rep  2022  12(1):2711  PubMed ID: 35177646   DOI: 10.1038/s41598-022-04980-y
20852  Minematsu H, Afify SM, Sugihara Y, Hassan G, Zahra MH, Seno A, Adachi M, Seno M.  Cancer stem cells induced by chronic stimulation with prostaglandin E2 exhibited constitutively activated PI3K axis.  Sci Rep  2022  12(1):15628  PubMed ID: 36115905   DOI: 10.1038/s41598-022-19265-7
14071  Haque M, Xiong X, Lei F, Das JK, Song J.  An optimized protocol for the generation of HBV viral antigen-specific T lymphocytes from pluripotent stem cells  STAR Protoc  2021  2(1):100264  PubMed ID: 33490980   DOI: 10.1016/j.xpro.2020.100264
14282  Haque M, Lei F, Xiong X, Ren Y, Peng HY, Wang L, Kumar A, Das JK, Song J.  Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells  Viruses  2021  13(5):753  PubMed ID: 33923025   DOI: 10.3390/v13050753
20234  Zahra MH, Afify SM, Hassan G, Nawara HM, Kumon K, Seno A, Seno M.  Metformin suppresses self-renewal and stemness of cancer stem cell models derived from pluripotent stem cells.  Cell Biochem Funct  2021    PubMed ID: 34268768   DOI: 10.1002/cbf.3661
15510  Abu Quora HA, Zahra MH, El-Ghlban S, Nair N, Afify SM, Hassan G, Nawara HM, Sheta M, Monzur S, Fu X, Osman A, Seno A, Seno M.  Microenvironment of mammary fat pads affected the characteristics of the tumors derived from the induced cancer stem cells  Am J Cancer Res  2021  11(7):3475-3495  PubMed ID: 34354856  
20480  Kumon K, Afify SM, Hassan G, Ueno S, Monzur S, Nawara HM, Quora HAA, Sheta M, Xu Y, Fu X, Zahra MH, Seno A, Seno M.  Differentiation of cancer stem cells into erythroblasts in the presence of CoCl2.  Sci Rep  2021  11(1):23977  PubMed ID: 34907219   DOI: 10.1038/s41598-021-03298-5
20492  Hassan G, Afify SM, Du J, Nawara HM, Sheta M, Monzur S, Zahra MH, Abu Quora HA, Mansour H, El-Ghlban S, Uesaki R, Seno A, Seno M.  MEK1/2 is a bottleneck that induces cancer stem cells to activate the PI3K/AKT pathway.  Biochem Biophys Res Commun  2021  583:49-55  PubMed ID: 34735879   DOI: 10.1016/j.bbrc.2021.10.047
16756  Tadashi Kosawada, Taku Kitsunai, Zhonggang Feng, Kaoru Goto  A Novel In Vitro Simulator to Investigate Promotion of Reconstruction of Damaged Neuronal Cell Colony Differentiated from iPS Cells with the Aid of Micro Dynamic Stimulation  Technologies  2021  9:83    DOI: 10.3390/technologies9040083
11626  Odashima A, Onodera S, Saito A, Ogihara Y, Ichinohe T, Azuma T.  Stage-dependent differential gene expression profiles of cranial neural crest-like cells derived from mouse-induced pluripotent stem cells.  Med Mol Morphol  2020  53(1):28-41  PubMed ID: 31297611   DOI: 10.1007/s00795-019-00229-2
11884  Yoshioka K, Ito A, Kawabe Y, Kamihira M.  Novel neuromuscular junction model in 2D and 3D myotubes co-cultured with induced pluripotent stem cell-derived motor neurons.  J. Biosci. Bioeng.  2020  129(4):486-493  PubMed ID: 31678066   DOI: 10.1016/j.jbiosc.2019.10.004
10439  Haque M, Lei F, Xiong X, Ren Y, Kumar A, Das JK, Ren X, Fang D, de Figueiredo P, Yang JM, Song J.  Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication Through Production of IFN-γ and TNF-⍺  iScience  2020  23(7):101333  PubMed ID: 32679546   DOI: 10.1016/j.isci.2020.101333
11917  Tamai M, Uchisawa H, Saito Y, Matsue H, Kawase M, Naraoka T, Tagawa YI.  Acorbine, a Corbicula japonica-derived tripeptide containing non-proteinogenic amino acids, suppresses ethanol-induced liver injury.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 31784088   DOI: 10.1016/j.bbrc.2019.11.131
11923  Imamura O, Arai M, Dateki M, Oishi K, Takishima K.  Donepezil-induced oligodendrocyte differentiation is mediated through estrogen receptors.  J. Neurochem.  2020    PubMed ID: 31778582   DOI: 10.1111/jnc.14927
10146  Juan Du 1, Yanning Xu 1 2, Saki Sasada 1, Aung Ko Ko Oo 1, Ghmkin Hassan 3 4, Hafizah Mahmud 1, Apriliana Cahya Khayrani, Md Jahangir Alam, Kazuki Kumon, Ryo Uesaki, Said M Afify, Hager M Mansour, Neha Nair, Maram H Zahra, Akimasa Seno, Nobuhiro Okada, Ling Chen, Ting Yan, Masaharu Sen0  Signaling Inhibitors Accelerate the Conversion of mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment  Sci Rep .  2020  10(1):9955  PubMed ID: 32572057   DOI: 10.1038/s41598-020-66471-2
13039  Nawara HM, M Afify S, Hassan G, Zahra MH, Atallah MN, Mansour H, Abu Quora HA, Alam MJ, Osman A, Kakuta H, Hamada H, Seno A, Seno M.  Paclitaxel and Sorafenib: The Effective Combination of Suppressing the Self-Renewal of Cancer Stem Cells.  Cancers (Basel)  2020    PubMed ID: 32466563   DOI: 10.3390/cancers12061360
13176  Mansour H, Hassan G, Afify SM, Yan T, Seno A, Seno M.  Metastasis Model of Cancer Stem Cell-Derived Tumors.  Methods Protoc  2020    PubMed ID: 32825540   DOI: 10.3390/mps3030060
13285  Onishi A, Abdullah AN, Tanimoto K, Kato K.  Optimization of culture conditions for the efficient differentiation of mouse-induced pluripotent stem cells into dental epithelial-like cells.  In Vitro Cell Dev Biol Anim  2020    PubMed ID: 33051833   DOI: 10.1007/s11626-020-00505-x
13616  Ishizuka T, Nagata W, Nomura-Takahashi S, Satoh Y.  Effects of oxidized low-density lipoprotein on differentiation of mouse neural progenitor cells into neural cells  Eur J Pharmacol  2020  888:173456  PubMed ID: 32771670   DOI: 10.1016/j.ejphar.2020.173456
13926  Yamauchi Y, Hirata I, Tanimoto K, Kato K.  Epidermal growth factor-immobilized surfaces for the selective expansion of neural progenitor cells derived from induced pluripotent stem cells  Biotechnol Bioeng  2020  117(9):2741-2748  PubMed ID: 32572957   DOI: 10.1002/bit.27445
13946  Juan Du et al  Upregulated CCL20 and CCR6 in Cancer Stem Cells Converted from Mouse iPS Cells  Journal of Research in Medical and Dental Science  2020  8:200-207   
14058  Hamamura K, Hotta H, Murakumo Y, Shibuya H, Kondo Y, Furukawa K.  SSEA-3 and 4 are not essential for the induction or properties of mouse iPS cells  J Oral Sci  2020  62(4):393-396  PubMed ID: 32684574   DOI: 10.2334/josnusd.19-0513
14059  Sato M, Aoki H, Nakamura T, Onodera S, Yamaguchi A, Saito A, Azuma T.  Effects of intermittent treatment with parathyroid hormone (PTH) on osteoblastic differentiation and mineralization of mouse induced pluripotent stem cells in a 3D culture model  J Periodontal Res  2020  55(5):734-743  PubMed ID: 32583900   DOI: 10.1111/jre.12762
11316  Chen X, Lei F, Wang L, Xiong X, Song J.  Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells.  Methods Mol. Biol.  2019    PubMed ID: 30465194   DOI: 10.1007/978-1-4939-8885-3_3
11393  Abdullah AN, Miyauchi S, Onishi A, Tanimoto K, Kato K.  Differentiation of mouse-induced pluripotent stem cells into dental epithelial-like cells in the absence of added serum.  In Vitro Cell. Dev. Biol. Anim.  2019    PubMed ID: 30659476   DOI: 10.1007/s11626-019-00320-z
11441  Haque M, Lei F, Xiong X, Das JK, Ren X, Fang D, Salek-Ardakani S, Yang JM, Song J.  Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes.  JCI Insight  2019    PubMed ID: 30777937   DOI: 10.1172/jci.insight.126471
11489  Kasuda S, Kudo R, Yuui K, Sakurai Y, Hatake K.  Induced Pluripotent Stem Cell-Derived Hematopoietic Embryoid Bodies Improve Mouse Status in Septic Peritonitis.  Bull. Exp. Biol. Med.  2019    PubMed ID: 30903503   DOI: 10.1007/s10517-019-04414-2
11667  Akimasa Seno, Akifumi Mizutani, Kazuki Aizawa, Ryoma Onoue, Junko Masuda, Naotaka Ochi, Saki Taniguchi, Tatsuyuki Sota, Yuki Hiramoto, Taisuke Michiue, Neha Nair, Masaharu Seno  Daunorubicin can eliminate iPS-derived cancer stem cells via ICAD/CAD-independent DNA fragmentation  Cancer Drug Resist   2019    PubMed ID: 35582720   DOI: 10.20517/cdr.2019.01
11763  Afify SM, Hassan G, Osman A, Calle AS, Nawara HM, Zahra MH, El-Ghlban S, Mansour H, Alam MJ, Abu Quora HA, Du J, Seno A, Iwasaki Y, Seno M.  Metastasis of Cancer Stem Cells Developed in the Microenvironment of Hepatocellular Carcinoma.  Bioengineering (Basel)  2019  6(3)  PubMed ID: 31450740   DOI: 10.3390/bioengineering6030073
11862  Afify SM, Chen L, Yan T, Calle AS, Nair N, Murakami C, Zahra MH, Okada N, Iwasaki Y, Seno A, Seno M.  Method to Convert Stem Cells into Cancer Stem Cells.  Methods Protoc  2019    PubMed ID: 31426391   DOI: 10.3390/mps2030071
6880  Hontani K, Onodera T, Terashima M, Momma D, Matsuoka M, Baba R, Joutoku Z, Matsubara S, Homan K, Hishimura R, Xu L, Iwasaki N.  Chondrogenic differentiation of mouse induced pluripotent stem cells using the three-dimensional culture with ultra-purified alginate gel.  J Biomed Mater Res A  2019  107(5):1086-1093  PubMed ID: 30665260   DOI: 10.1002/jbm.a.36615
6881  Toru Momozane et al  Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor  Stem Cells International  2019  2019, Article ID 1271682  PubMed ID: 31949433   DOI: 10.1155/2019/1271682
12305  Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, Sato H, Komoto S, Narusaka T, Tomono Y, Xing B, Chen Y, Tazawa H, Kagawa S, Shirakawa Y, Kasai T, Seno M, Matsukawa A, Fujiwara T.  A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness  Cancers (Basel)  2019  11(2):177  PubMed ID: 30717462   DOI: 10.3390/cancers11020177
12478  Yoshie S, Nakamura R, Kobayashi D, Miyake M, Omori K, Hazama A.  Functional characterization of various channel-expressing central airway epithelial cells from mouse induced pluripotent stem cells  J Cell Physiol  2019    PubMed ID: 30714154   DOI: 10.1002/jcp.28254
12479  Al-Wahabi A, Ser-Od T, Inoue K, Nakajima K, Matsuzaka K, Inoue T.  Topography enhances Runx2 expression in outgrowing cells from iPS cell-derived embryoid bodies  J Biomed Mater Res B Appl Biomater  2019  107(7):2288-2296  PubMed ID: 30735289   DOI: 10.1002/jbm.b.34321
12480  Paerhati P, Ito A, Yoshioka K, Iwamoto K, Fujiwara S, Horie M, Kawabe Y, Kamihira M.  Neural differentiation of mouse induced pluripotent stem cells using cadherin gene-engineered PA6 feeder cells  J Biosci Bioeng  2019  127(5):633-640  PubMed ID: 30391238   DOI: 10.1016/j.jbiosc.2018.10.009
14813  Xiong X, Lei F, Haque M, Song J.  Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice  J Vis Exp  2019  (151):10.3791/60043  PubMed ID: 31609353   DOI: 10.3791/60043
17179  Kouno T, Moody J, Kwon AT, Shibayama Y, Kato S, Huang Y, Böttcher M, Motakis E, Mendez M, Severin J, Luginbühl J, Abugessaisa I, Hasegawa A, Takizawa S, Arakawa T, Furuno M, Ramalingam N, West J, Suzuki H, Kasukawa T, Lassmann T, Hon CC, Arner E, Carninci P, Plessy C, Shin JW.  C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution  Nat Commun  2019  10(1):360  PubMed ID: 30664627   DOI: 10.1038/s41467-018-08126-5
9503  Kitadani J, Ojima T, Iwamoto H, Tabata H, Nakamori M, Nakamura M, Hayata K, Katsuda M, Miyajima M, Yamaue H.  Cancer Vaccine Therapy Using Carcinoembryonic Antigen - expressing Dendritic Cells generated from Induced Pluripotent Stem Cells.  Sci Rep  2018  8:4569  PubMed ID: 29545628   DOI: 10.1038/s41598-018-23120-z
10544  Osawa Y, Miyamoto T, Ohno S, Ohno E.  Morphological Analysis of Live Undifferentiated Cells Derived from Induced Pluripotent Stem Cells.  Stem Cells Dev.  2018  27:1-9  PubMed ID: 28978257   DOI: 10.1089/scd.2017.0112
11029    Craniofacial Bone Regeneration using iPS Cell-Derived Neural Crest Like Cells  Journal of Hard Tissue Biology  2018  27, 1-10    DOI: 10.2485/jhtb.27.1
11197  Kimura Y, Kasai K, Miyata S.  Feeder-free culture for mouse induced pluripotent stem cells by using UV/ozone surface-modified substrates.  Mater Sci Eng C Mater Biol Appl  2018  92:280-286  PubMed ID: 30184752   DOI: 10.1016/j.msec.2018.06.053
4257  Xu N, Li X, Watanabe M, Ueki H, Hu H, Li N, Araki M, Wada K, Xu A, Liu C, Nasu Y, Huang P.  Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium.  Am J Cancer Res  2018    PubMed ID: 30210930  
4258  Hisanaga Y, Suzuki E, Aoki H, Sato M, Saito A, Saito A, Azuma T.  Effect of the combined use of enamel matrix derivative and atelocollagen sponge scaffold on osteoblastic differentiation of mouse induced pluripotent stem cells in vitro.  J. Periodont. Res.  2018    PubMed ID: 29044527   DOI: 10.1111/jre.12511
4259  Ishizuka T, Ozawa A, Katsuura M, Nomura S, Satoh Y.  Effects of muscarinic acetylcholine receptor stimulation on the differentiation of mouse induced pluripotent stem cells into neural progenitor cells.  Clin. Exp. Pharmacol. Physiol.  2018    PubMed ID: 29920752   DOI: 10.1111/1440-1681.12993
14910  Alam MJ, Takahashi R, Afify SM, Oo AKK, Kumon K, Nawara HM, Khayrani AC, Du J, Zahra MH, Seno A, Salomon DS, Seno M.  Exogenous Cripto-1 Suppresses Self-Renewal of Cancer Stem Cell Model  Int J Mol Sci  2018  19(11):3345  PubMed ID: 30373174   DOI: 10.3390/ijms19113345
7028  Nair N, Calle AS, Zahra MH, Prieto-Vila M, Oo AKK, Hurley L, Vaidyanath A, Seno A, Masuda J, Iwasaki Y, Tanaka H, Kasai T, Seno M.  A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment.  Sci Rep  2017  7:6838  PubMed ID: 28754894   DOI: 10.1038/s41598-017-07144-5
7041  Wu J, Platero-Luengo A, Sakurai M, Sugawara A, Gil MA, Yamauchi T, Suzuki K, Bogliotti YS, Cuello C, Morales Valencia M, Okumura D, Luo J, Vilarino M, Parrilla I, Soto DA, Martinez CA, Hishida T, Sanchez-Bautista S, Martinez-Martinez ML, Wang H, Nohalez A, Aizawa E, Martinez-Redondo P, Ocampo A, Reddy P, Roca J, Maga EA, Esteban CR, Berggren WT, Nunez Delicado E, Lajara J, Guillen I, Guillen P, Campistol JM, Martinez EA, Ross PJ, Izpisua Belmonte JC.  Interspecies Chimerism with Mammalian Pluripotent Stem Cells.  Cell  2017  168:473-486.e15  PubMed ID: 28129541   DOI: 10.1016/j.cell.2016.12.036
10340  Ogawa Y, Kaizu K, Yanagi Y, Takada S, Sakuraba H, Oishi K.  Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage.  PLoS ONE  2017  12:e0178978  PubMed ID: 28575132   DOI: 10.1371/journal.pone.0178978
10974    Abstract 925: Tumorigenesis of murine iPS cell is prevented by iron depletion with downregulation of stemness markers  Cancer Research  2017  77:925-925     DOI: 10.1158/1538-7445.AM2017-925
5445  Ninomiya T, Ohara T, Noma K, Katsura Y, Katsube R, Kashima H, Kato T, Tomono Y, Tazawa H, Kagawa S, Shirakawa Y, Kimura F, Chen L, Kasai T, Seno M, Matsukawa A, Fujiwara T.  Iron depletion is a novel therapeutic strategy to target cancer stem cells.  Oncotarget  2017  8(58):98405-98416  PubMed ID: 29228699   DOI: 10.18632/oncotarget.21846
6177  Takeda H, Minoda R, Miwa T, Yamada T, Ise M.  Transplanting mouse induced pluripotent stem cells into mouse otocysts in vivo.  Neurosci Lett  2017  647:153-158  PubMed ID: 28359931   DOI: 10.1016/j.neulet.2017.03.014
6178  Tokita R, Nakajima K, Inoue K, Al-Wahabi A, Ser-Od T, Matsuzaka K, Inoue T.  Differentiation behavior of iPS cells cultured on PLGA with osteoinduction medium.  Dent Mater J  2017  36(1):103-110  PubMed ID: 28090031   DOI: 10.4012/dmj.2016-087
6179  Lei F, Haque M, Sandhu P, Ravi S, Song J, Ni B, Zheng S, Fang D, Jia H, Yang JM, Song J.  Development and characterization of naive single-type tumor antigen-specific CD8+ T lymphocytes from murine pluripotent stem cells.  Oncoimmunology  2017  6(7):e1334027  PubMed ID: 28811978   DOI: 10.1080/2162402X.2017.1334027
7087  Ikeda M, Imaizumi M, Yoshie S, Otsuki K, Miyake M, Hazama A, Wada I, Omori K.  Regeneration of tracheal epithelium using mouse induced pluripotent stem cells.  Acta Otolaryngol.  2016  136:373-8  PubMed ID: 26755348   DOI: 10.3109/00016489.2015.1121548
7095  T Kosawada, T Koizumi, K Ugajin, Z Feng, K Goto  Novel three-dimensional micro vibration actuator for imposing dynamic stimulations to promote differentiation of iPS cells.  Microsyst Technol  2016  22:45-56    DOI: 10.1007/s00542-015-2644-y
9545  Yan Y, Yin P, Gong H, Xue Y, Zhang G, Fang B, Chen Z, Li Y, Yang C, Huang Z, Yang X, Ge J, Zou Y.  Nucleosome Assembly Protein 1-Like 1 (Nap1l1) Regulates the Proliferation of Murine Induced Pluripotent Stem Cells.  Cell. Physiol. Biochem.  2016  38:340-50  PubMed ID: 26824453   DOI: 10.1159/000438634
9666  Miyamoto D, Nakazawa K.  Differentiation of mouse iPS cells is dependent on embryoid body size in microwell chip culture.  J. Biosci. Bioeng.  2016  122:507-12  PubMed ID: 27090344   DOI: 10.1016/j.jbiosc.2016.03.018
9710  Shirouzu Y, Yanai G, Yang KC, Sumi S.  Effects of Activin in Embryoid Bodies Expressing Fibroblast Growth Factor 5.  Cell Reprogram  2016  18:171-86  PubMed ID: 27253628   DOI: 10.1089/cell.2015.0074
9757  Higuchi S, Yoshina S, Mitani S.  Inhibition of the integrin signal constitutes a mouse iPS cell niche.  Dev. Growth Differ.  2016  58:586-99  PubMed ID: 27633818   DOI: 10.1111/dgd.12302
6180  Mitomo H, Eguchi A, Suzuki Y, Matsuo Y, Niikura K, Nakazawa K, Ijiro K.  Fabrication of a Novel Cell Culture System Using DNA-Grafted Substrates and DNase.  J Biomed Nanotechnol  2016  12(2):286-95  PubMed ID: 27305762   DOI: 10.1166/jbn.2016.2188
6181  Nakamura M, Kamishibahara Y, Kitazawa A, Kawaguchi H, Shimizu N.  Differentiation patterns of mouse embryonic stem cells and induced pluripotent stem cells into neurons.  Cytotechnology  2016  68(3):409-17  PubMed ID: 25354731   DOI: 10.1007/s10616-014-9792-2
12682  Yoshie S, Imaizumi M, Nakamura R, Otsuki K, Ikeda M, Nomoto Y, Wada I, Omori K.  Generation of airway epithelial cells with native characteristics from mouse induced pluripotent stem cells  Cell Tissue Res  2016  364(2):319-30  PubMed ID: 26590823   DOI: 10.1007/s00441-015-2304-7
12902  Haque M, Song J, Fino K, Sandhu P, Wang Y, Ni B, Fang D, Song J.  Melanoma Immunotherapy in Mice Using Genetically Engineered Pluripotent Stem Cells  Cell Transplant  2016  25(5):811-27.  PubMed ID: 26777320   DOI: 10.3727/096368916X690467
14147  Haque M, Song J, Fino K, Sandhu P, Song X, Lei F, Zheng S, Ni B, Fang D, Song J.  Stem cell-derived tissue-associated regulatory T cells ameliorate the development of autoimmunity  Sci Rep  2016  6:20588  PubMed ID: 26846186   DOI: 10.1038/srep20588
14187  Sasaki Mizuki, Hirata Mitsuhi, Yamaoka Tetsuji, Tamada Yasushi  Growth of mouse iPS cells on silk fibroin substrate  Frontiers in Bioengineering and Biotechnology  2016  4    DOI: 10.3389/conf.fbioe.2016.01.01481
6182  Horie M, Ito A, Maki T, Kawabe Y, Kamihira M.  Magnetically labeled feeder system for mouse pluripotent stem cell culture.  J Biosci Bioeng  2015  119(5):614-6  PubMed ID: 25468421   DOI: 10.1016/j.jbiosc.2014.10.020
6183  Yamazoe T, Koizumi S, Yamasaki T, Amano S, Tokuyama T, Namba H.  Potent tumor tropism of induced pluripotent stem cells and induced pluripotent stem cell-derived neural stem cells in the mouse intracerebral glioma model.  Int J Oncol  2015  46(1):147-52  PubMed ID: 25310640   DOI: 10.3892/ijo.2014.2702
6184  Lee J, Nakajima-Koyama M, Sone M, Koga M, Ebisuya M, Yamamoto T, Nishida E  Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction.  Stem Cell Reports  2015  5(4):480-9  PubMed ID: 26441306   DOI: 10.1016/j.stemcr.2015.09.001
12477  Yang JJ, Liu JF, Kurokawa T, Kitada K, Gong JP.  Hydrogels as feeder-free scaffolds for long-term self-renewal of mouse induced pluripotent stem cells  J Tissue Eng Regen Med  2015  9(4):375-88  PubMed ID: 23166055   DOI: 10.1002/term.1640
14997  Komura T, Kato K, Konagaya S, Nakaji-Hirabayashi T, Iwata H.  Optimization of surface-immobilized extracellular matrices for the proliferation of neural progenitor cells derived from induced pluripotent stem cells  Biotechnol Bioeng  2015  112(11):2388-96   PubMed ID: 25943789   DOI: 10.1002/bit.25636
15137  Zhou Y, Mao H, Joddar B, Umeki N, Sako Y, Wada K, Nishioka C, Takahashi E, Wang Y, Ito Y.  The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness  Sci Rep  2015  5:11386  PubMed ID: 26065582   DOI: 10.1038/srep11386
14858  Horiguchi I, Sakai Y.  Alginate Encapsulation of Pluripotent Stem Cells Using a Co-axial Nozzle  J Vis Exp  2015  (101):e5283  PubMed ID: 26168084   DOI: 10.3791/52835
17438  Haque A, Adnan N, Motazedian A, Akter F, Hossain S, Kutsuzawa K, Nag K, Kobatake E, Akaike T.  An Engineered N-Cadherin Substrate for Differentiation, Survival, and Selection of Pluripotent Stem Cell-Derived Neural Progenitors  PLoS One  2015  10(8):e0135170  PubMed ID: 26244942   DOI: 10.1371/journal.pone.0135170
6002  Gong H, Yan Y, Fang B, Xue Y, Yin P, Li L, Zhang G, Sun X, Chen Z, Ma H, Yang C, Ding Y, Yong Y, Zhu Y, Yang H, Komuro I, Ge J, Zou Y.  Knockdown of nucleosome assembly protein 1-like 1 induces mesoderm formation and cardiomyogenesis via notch signaling in murine-induced pluripotent stem cells.  Stem Cells  2014  32(7):1759-73  PubMed ID: 24648372   DOI: 10.1002/stem.1702
6186  Tamaki S, Tokumoto Y.  Overexpression of cyclin dependent kinase inhibitor P27/Kip1 increases oligodendrocyte differentiation from induced pluripotent stem cells.  In Vitro Cell Dev Biol Anim  2014  50(8):778-85  PubMed ID: 24764126   DOI: 10.1007/s11626-014-9753-2
6187  Lei F, Haque R, Xiong X, Song J.  Modulation of autoimmune diseases by iPS cells  Methods Mol Biol  2014  1213:365-7  PubMed ID: 25173398   DOI: 10.1007/978-1-4939-1453-1_30
6188  Makoto NishimoriHiromasa YakushijiMichihiro MoriTomoyuki MiyamotoTakahiro YaguchiSetsuyo OhnoYasuyuki MiyakeTakuya SakaguchiMasatsugu UedaEiji Ohno  Tumorigenesis in cells derived from induced pluripotent stem cells  Human Cell  2014  27:29–35  PubMed ID: 24122447   DOI: 10.1007/s13577-013-0078-3
6189  Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, El-Aarag BY, Liu Y, Kudoh T, Salomon DS, Fu L, Seno M.  Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells.  Am J Cancer Res  2014  4(1):80-8  PubMed ID: 24482741  
6190  Otsuki K, Imaizumi M, Nomoto Y, Nomoto M, Wada I, Miyake M, Omori K.  Effective embryoid body formation from induced pluripotent stem cells for regeneration of respiratory epithelium.  Laryngoscope  2014  124(1):E8-14  PubMed ID: 23686377   DOI: 10.1002/lary.24201
6191  Iwamoto H, Ojima T, Hayata K, Katsuda M, Miyazawa M, Iida T, Nakamura M, Nakamori M, Iwahashi M, Yamaue H.  Antitumor immune response of dendritic cells (DCs) expressing tumor-associated antigens derived from induced pluripotent stem cells: in comparison to bone marrow-derived DCs.  Int J Cancer  2014  134(2):332-41  PubMed ID: 23824921   DOI: 10.1002/ijc.28367
6192  Koga M, Matsuda M, Kawamura T, Sogo T, Shigeno A, Nishida E, Ebisuya M.  Foxd1 is a mediator and indicator of the cell reprogramming process.  Nat Commun.  2014  5:3197  PubMed ID: 24496101   DOI: 10.1038/ncomms4197
6193  Kuise T, Noguchi H1, Tazawa H, Kawai T, Iwamuro M, Saitoh I, Kataoka HU, Watanabe M, Noguchi Y, Fujiwara T.  Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells.  Biomed Eng Online  2014  13:64  PubMed ID: 24886514   DOI: 10.1186/1475-925X-13-64
6194  Yoji Tabata ab, Ikki Horiguchi a, Matthias P. Lutolf b and Yasuyuki Sakai   Development of bioactive hydrogel capsules for the 3D expansion of pluripotent stem cells in bioreactors  Biomater. Sci  2014  2:176-183  PubMed ID: 32481877   DOI: 10.1039/C3BM60183H
6196  Horiguchi I, Chowdhury MM, Sakai Y, Tabata Y.  Proliferation, morphology, and pluripotency of mouse induced pluripotent stem cells in three different types of alginate beads for mass production.  Biotechnol Prog  2014  30(4):896-904  PubMed ID: 24585713   DOI: 10.1002/btpr.1891
6197  Yan T, Mizutani A, Chen L, Takaki M, Hiramoto Y, Matsuda S, Shigehiro T, Kasai T, Kudoh T, Murakami H, Masuda J, Hendrix MJ, Strizzi L, Salomon DS, Fu L, Seno M.  Characterization of cancer stem-like cells derived from mouse induced pluripotent stem cells transformed by tumor-derived extracellular vesicles.  J Cancer  2014  5(7):572-84  PubMed ID: 25057308   DOI: 10.7150/jca.8865
15796  Fort A, Hashimoto K, Yamada D, Salimullah M, Keya CA, Saxena A, Bonetti A, Voineagu I, Bertin N, Kratz A, Noro Y, Wong CH, de Hoon M, Andersson R, Sandelin A, Suzuki H, Wei CL, Koseki H, FANTOM Consortium, Hasegawa Y, Forrest AR, Carninci P.  Deep transcriptome profiling of mammalian stem cells supports a regulatory role for retrotransposons in pluripotency maintenance  Nat Genet  2014  46(6):558-66  PubMed ID: 24777452   DOI: 10.1038/ng.2965
17113  Ishizuka T, Goshima H, Ozawa A, Watanabe Y.  Stimulation of 5-HT4 receptor enhances differentiation of mouse induced pluripotent stem cells into neural progenitor cells  Clin Exp Pharmacol Physiol  2014  41(5):345-50  PubMed ID: 24606396   DOI: 10.1111/1440-1681.12224
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6199  Uto S, Nishizawa S, Takasawa Y, Asawa Y, Fujihara Y, Takato T, Hoshi K.  Bone and cartilage repair by transplantation of induced pluripotent stem cells in murine joint defect model.  Biomed Res  2013  34(6):281-8  PubMed ID: 24389404   DOI: 10.2220/biomedres.34.281
6200  Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.  iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis.  Sci Rep  2013  3:1418  PubMed ID: 23475393   DOI: 10.1038/srep01418
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6203  Imaizumi M, Nomoto Y, Sugino T, Otsuki K, Omori K.  Implantation site-dependent differences for tracheal regeneration with induced pluripotent stem cells (iPS cells).  Acta Otolaryngol  2013  133(4):405-11  PubMed ID: 23675768   DOI: 10.3109/00016489.2012.742566
6204  Yamasaki S, Nabeshima K, Sotomaru Y, Taguchi Y, Mukasa H, Furue MK, Sato JD, Okamoto T.  Long-term serial cultivation of mouse induced pluripotent stem cells in serum-free and feeder-free defined medium.  Int J Dev Biol  2013  57(9-10):715-24  PubMed ID: 24307297   DOI: 10.1387/ijdb.130173to
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6207  Misumi S, Nishigaki R, Ueda Y, Watanabe Y, Shimizu Y, Ishida A, Jung C, Hida H.  Differentiation of oligodendrocytes from mouse induced pluripotent stem cells without serum.  Transl Stroke Res  2013  4(2):149-57  PubMed ID: 24323274   DOI: 10.1007/s12975-012-0250-1
6208  Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K.  Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease.  PLoS One  2013  8(1):e55856  PubMed ID: 23383290   DOI: 10.1371/journal.pone.0055856
6209  Maruyama M, Yamashita Y, Kase M, Trifonov S, Sugimoto T.  Lineage-specific purification of neural stem/progenitor cells from differentiated mouse induced pluripotent stem cells.  Stem Cells Transl Med  2013  2(6):420-33  PubMed ID: 23694811   DOI: 10.5966/sctm.2012-0139
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6211  Iwamuro M, Shiraha H, Nakaji S, Furutani M, Kobayashi N, Takaki A, Yamamoto K.  A preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes.  Biomed Eng Online  2012  11:93  PubMed ID: 23217363   DOI: 10.1186/1475-925X-11-93
6212  Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S.  Role of epithelial-stem cell interactions during dental cell differentiation.  J Biol Chem  2012  287(13):10590-601  PubMed ID: 22298769   DOI: 10.1074/jbc.M111.285874
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13932  Miyamoto Y, Noguchi H, Yukawa H, Oishi K, Matsushita K, Iwata H, Hayashi S.  Cryopreservation of Induced Pluripotent Stem Cells  Cell Med  2012  3(1-3):89-95  PubMed ID: 28058185   DOI: 10.3727/215517912X639405
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7707  Hayashi K, Hashimoto M, Koda M, Naito AT, Murata A, Okawa A, Takahashi K, Yamazaki M.  Increase of sensitivity to mechanical stimulus after transplantation of murine induced pluripotent stem cell-derived astrocytes in a rat spinal cord injury model.  J Neurosurg Spine  2011  15:582-93  PubMed ID: 21854127   DOI: 10.3171/2011.7.SPINE10775
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19152  Masanobu Horie, Akira Ito  A Genetically Engineered STO Feeder System Expressing E-Cadherin and Leukemia Inhibitory Factor for Mouse Pluripotent Stem Cell Culture  Journal of Bioprocessing & Biotechniques  2011  01    DOI: 10.4172/2155-9821.s3-001
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