Cell No. : Cell Name RCB5674 : Y-MESO-29  update : 2024/02/07
Comment			Currently not ready.
Comment from the depositor			Human malignant pleural mesothelioma cell line. This cell line was established from the pleural effusion of epithelioid type MPM of a patient.
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			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Expected time	Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
		Cellosaurus(Expasy)	CVCL_5186
Reference information		Reference	13
		User's Publication	0

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Reference

16027  Matsushita A, Sato T, Mukai S, Fujishita T, Mishiro-Sato E, Okuda M, Aoki M, Hasegawa Y, Sekido Y.  TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation  Oncogene  2018  38(11):1966-1978  PubMed ID: 30401981   DOI: 10.1038/s41388-018-0417-7

16467  Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y.  Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis  Cancer Lett  2017  385:215-224.  PubMed ID: 27773750   DOI: 10.1016/j.canlet.2016.10.020

16477  Kato T, Sato T, Yokoi K, Sekido Y.  E-cadherin expression is correlated with focal adhesion kinase inhibitor resistance in Merlin-negative malignant mesothelioma cells  Oncogene  2017  36(39):5522-5531  PubMed ID: 28553954   DOI: 10.1038/onc.2017.147

16026  Kakiuchi T, Takahara T, Kasugai Y, Arita K, Yoshida N, Karube K, Suguro M, Matsuo K, Nakanishi H, Kiyono T, Nakamura S, Osada H, Sekido Y, Seto M, Tsuzuki S.  Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation  Carcinogenesis  2016  37(11):1098-1109  PubMed ID: 27559111   DOI: 10.1093/carcin/bgw084

16468  Hakiri S, Osada H, Ishiguro F, Murakami H, Murakami-Tonami Y, Yokoi K, Sekido Y.  Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells  Cancer Sci  2015  106(8):990-9.  PubMed ID: 26011428   DOI: 10.1111/cas.12698

16469  Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y.  LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade  Oncogene  2015  34(1):73-83  PubMed ID: 24336325   DOI: 10.1038/onc.2013.528

16456  Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y.  Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells  Ann Surg Oncol  2012  19 Suppl 3(Suppl 3):S634-45  PubMed ID: 22086445   DOI: 10.1245/s10434-011-2142-0

16471  Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y.  YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes  Oncogene  2012  31(49):5117-22  PubMed ID: 22286761   DOI: 10.1038/onc.2012.5

16472  Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y.  Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma  J Thorac Oncol  2012  7(5):890-9  PubMed ID: 22722789   DOI: 10.1097/JTO.0b013e31824af2db

16473  Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.  TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth  J Exp Med  2012  209(3):479-94  PubMed ID: 22329991   DOI: 10.1084/jem.20111653

16474  Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.  LATS2 is a tumor suppressor gene of malignant mesothelioma  Cancer Res  2011  71(3):873-83  PubMed ID: 21245096   DOI: 10.1158/0008-5472.CAN-10-2164

16457  Suzuki Y, Murakami H, Kawaguchi K, Tanigushi T, Fujii M, Shinjo K, Kondo Y, Osada H, Shimokata K, Horio Y, Hasegawa Y, Hida T, Sekido Y.  Activation of the PI3K-AKT pathway in human malignant mesothelioma cells  Mol Med Rep  2009  2(2):181-8  PubMed ID: 21475810   DOI: 10.3892/mmr_00000081

16475  Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y.  Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells  Carcinogenesis  2009  30(7):1097-105  PubMed ID: 19380521   DOI: 10.1093/carcin/bgp097

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