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細胞番号 : 細胞名
RCB5665 : Y-MESO-8D  update : 2024/03/15
細胞特性(Comment:英)RCB5664 Y-MESO-8A, RCB5665 Y-MESO-8D were derived from the same patient.
細胞特性(日)RCB5664 Y-MESO-8A、RCB5665 Y-MESO-8Dは同一人由来。
細胞特性(寄託者記述:英)Human malignant pleural mesothelioma cell line. The primary tumor is a biphasic (predominantly sarcomatoid) tumor tissue. Subcloned from patient's pleural fluid and shows sarcomatoid morphology.
細胞特性(寄託者記述:日)ヒト悪性胸膜中皮腫細胞株。原発巣は2相型(肉腫型が主)の腫瘍組織。患者胸水よりサブクローニングされて樹立され肉腫型(sarcomatoid)の形態を示す。
使用条件(英)In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature (Cancer Sci 2006 97:387-394) designated by the DEPOSITOR is requested.
使用条件(日)研究成果の公表にあたって寄託者の指定する文献 (Cancer Sci 2006 97:387-394) を引用すること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 SEKIDO, Yoshitaka
樹立者 SEKIDO, Yoshitaka
寄託日 2022
元の細胞 Y-MESO-8
クローニング(寄託者) Yes
クローニングの時期(寄託者) 2001
クローニングの方法(寄託者) ring cloning
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
61 years
採取組織 pleural effusion
原発組織 malignant pleural mesothelioma
病歴 malignant pleural mesothelioma
腫瘍 malignant pleural mesothelioma (biphasic (predominantly sarcomatoid)
転移 Unknown
細胞分類 cancer
遺伝子改変 non-recombinant
初代培養日 2001
細胞寿命 infinite
細胞形態 fibroblast-like
Cellosaurus(Expasy) CVCL_5189
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells Adherent cells
培地 RPMI1640 + 10% FBS RPMI1640 + 10% FBS
抗生物質 1% antimicrobial Free
継代方法 0.25w/v% Trypsin + 1mmol/l EDTA(FUJIFILM 209-16941) 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
継代密度 1 : 5-8 split 1 : 5 split
継代・培地交換頻度 Subculture : 1-2 times/week Subculture : 1-2 times/week
培養最適温度 37 ℃ 37 ℃
二酸化炭素濃度 5 % 5 %
凍結培地 CELLBANKER CELLBANKER 1
凍結方法 Slow freezing
マイコプラズマ (-) (-)
動物種PCR OK
ウィルス(HIV) (-) Undetected
ウィルス(HTLV-1) (-)
ウィルス(HBV) (-)
ウィルス(HCV) (-)
ウィルス(EBV) (-)
個体識別検査 OK
寄託時情報
D5S818 D13S317 D7S820 D16S539 vWA TH01 Amelogenin TPOX CSF1PO
11,12 8,9 11 12 14,16 7,9 X,Y 11 11,12
ロット情報
D5S818 D13S317 D7S820 D16S539 vWA TH01 Amelogenin TPOX CSF1PO
11,12 8,9 11 12 14,16 7,9 X,Y 11 11,12
文献情報 Reference(英) 21件
Reference(日) 0件
利用者成果(英) 0件
利用者成果(日) 0件

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Reference(英)
17591  Hagiyama M, Mimae T, Wada A, Takeuchi F, Yoneshige A, Inoue T, Kotoku N, Hamada H, Sekido Y, Okada M, Ito A.  Possible Therapeutic Utility of anti-Cell Adhesion Molecule 1 Antibodies for Malignant Pleural Mesothelioma  Front Cell Dev Biol  2022  10:945007.  PubMed ID: 35903548   DOI: 10.3389/fcell.2022.945007
16466  Sato T, Mukai S, Ikeda H, Mishiro-Sato E, Akao K, Kobayashi T, Hino O, Shimono W, Shibagaki Y, Hattori S, Sekido Y.  Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation  Mol Cancer Res  2021  19(5):921-931  PubMed ID: 33574130   DOI: 10.1158/1541-7786.MCR-20-0637
16452  Okazaki Y, Misawa N, Akatsuka S, Kohyama N, Sekido Y, Takahashi T, Toyokuni S.  Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats  Cancer Sci  2020  111(4):1180-1192.  PubMed ID: 32080953   DOI: 10.1111/cas.14358
16027  Matsushita A, Sato T, Mukai S, Fujishita T, Mishiro-Sato E, Okuda M, Aoki M, Hasegawa Y, Sekido Y.  TAZ activation by Hippo pathway dysregulation induces cytokine gene expression and promotes mesothelial cell transformation  Oncogene  2018  38(11):1966-1978  PubMed ID: 30401981   DOI: 10.1038/s41388-018-0417-7
16453  Ohara Y, Chew SH, Misawa N, Wang S, Somiya D, Nakamura K, Kajiyama H, Kikkawa F, Tsuyuki Y, Jiang L, Yamashita K, Sekido Y, Lipson KE, Toyokuni S.  Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model  Oncotarget  2018  9(26):18494-18509  PubMed ID: 29719620   DOI: 10.18632/oncotarget.24892
16454  Chew SH, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, Ito F, Saya H, Sekido Y, Toyokuni S.  Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma  Free Radic Biol Med  2017  106:91-99  PubMed ID: 28185919   DOI: 10.1016/j.freeradbiomed.2017.02.011
16467  Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y.  Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis  Cancer Lett  2017  385:215-224.  PubMed ID: 27773750   DOI: 10.1016/j.canlet.2016.10.020
16026  Kakiuchi T, Takahara T, Kasugai Y, Arita K, Yoshida N, Karube K, Suguro M, Matsuo K, Nakanishi H, Kiyono T, Nakamura S, Osada H, Sekido Y, Seto M, Tsuzuki S.  Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation  Carcinogenesis  2016  37(11):1098-1109  PubMed ID: 27559111   DOI: 10.1093/carcin/bgw084
16468  Hakiri S, Osada H, Ishiguro F, Murakami H, Murakami-Tonami Y, Yokoi K, Sekido Y.  Functional differences between wild-type and mutant-type BRCA1-associated protein 1 tumor suppressor against malignant mesothelioma cells  Cancer Sci  2015  106(8):990-9.  PubMed ID: 26011428   DOI: 10.1111/cas.12698
16469  Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y.  LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade  Oncogene  2015  34(1):73-83  PubMed ID: 24336325   DOI: 10.1038/onc.2013.528
16455  Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S.  Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production  Carcinogenesis  2014  35(1):164-72  PubMed ID: 23917077   DOI: 10.1093/carcin/bgt267
16456  Horio M, Sato M, Takeyama Y, Elshazley M, Yamashita R, Hase T, Yoshida K, Usami N, Yokoi K, Sekido Y, Kondo M, Toyokuni S, Gazdar AF, Minna JD, Hasegawa Y.  Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells  Ann Surg Oncol  2012  19 Suppl 3(Suppl 3):S634-45  PubMed ID: 22086445   DOI: 10.1245/s10434-011-2142-0
16470  Elshazley M, Sato M, Hase T, Yamashita R, Yoshida K, Toyokuni S, Ishiguro F, Osada H, Sekido Y, Yokoi K, Usami N, Shames DS, Kondo M, Gazdar AF, Minna JD, Hasegawa Y.  The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma  Int J Cancer  2012  131(12):2820-31  PubMed ID: 22510946   DOI: 10.1002/ijc.27598
16471  Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, Kondo Y, Akatsuka S, Toyokuni S, Yokoi K, Osada H, Sekido Y.  YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes  Oncogene  2012  31(49):5117-22  PubMed ID: 22286761   DOI: 10.1038/onc.2012.5
16472  Ishiguro F, Murakami H, Mizuno T, Fujii M, Kondo Y, Usami N, Yokoi K, Osada H, Sekido Y.  Activated leukocyte cell-adhesion molecule (ALCAM) promotes malignant phenotypes of malignant mesothelioma  J Thorac Oncol  2012  7(5):890-9  PubMed ID: 22722789   DOI: 10.1097/JTO.0b013e31824af2db
16473  Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.  TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth  J Exp Med  2012  209(3):479-94  PubMed ID: 22329991   DOI: 10.1084/jem.20111653
16474  Murakami H, Mizuno T, Taniguchi T, Fujii M, Ishiguro F, Fukui T, Akatsuka S, Horio Y, Hida T, Kondo Y, Toyokuni S, Osada H, Sekido Y.  LATS2 is a tumor suppressor gene of malignant mesothelioma  Cancer Res  2011  71(3):873-83  PubMed ID: 21245096   DOI: 10.1158/0008-5472.CAN-10-2164
16457  Suzuki Y, Murakami H, Kawaguchi K, Tanigushi T, Fujii M, Shinjo K, Kondo Y, Osada H, Shimokata K, Horio Y, Hasegawa Y, Hida T, Sekido Y.  Activation of the PI3K-AKT pathway in human malignant mesothelioma cells  Mol Med Rep  2009  2(2):181-8  PubMed ID: 21475810   DOI: 10.3892/mmr_00000081
16475  Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y.  Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells  Carcinogenesis  2009  30(7):1097-105  PubMed ID: 19380521   DOI: 10.1093/carcin/bgp097
16458  Taniguchi T, Karnan S, Fukui T, Yokoyama T, Tagawa H, Yokoi K, Ueda Y, Mitsudomi T, Horio Y, Hida T, Yatabe Y, Seto M, Sekido Y.  Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32  Cancer Sci  2007  98(3):438-46  PubMed ID: 17270034   DOI: 10.1111/j.1349-7006.2006.00386.x
3337  Usami, Noriyasu, Fukui, Takayuki, Kondo, Masashi, Taniguchi, Tetsuo, Yokoyama, Toshihiko, Mori, Shoichi, Yokoi, Kohei, Horio, Yoshitsugu, Shimokata, Kaoru, Sekido, Yoshitaka, Hida, Toyoaki  Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.  Cancer Sci  2006  97:387-94  PubMed ID: 16630136   DOI: 10.1111/j.1349-7006.2006.00184.x

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