Cell No. : Cell Name RCB5326 : MRE11-TK6  update : 2022/09/06
Comment			Currently not ready.
Comment from the depositor			TK6 cells are one of the most commonly used human B lymphocyte-derived cell for cancer research. MRE11- disrupted TK6 cells.
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			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Expected time	Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
Reference information		Reference	10
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Reference

17860  Suzuki R, Murata MM, Manguso N, Watanabe T, Mouakkad-Montoya L, Igari F, Rahman MM, Qu Y, Cui X, Giuliano AE, Takeda S, Tanaka H.  The fragility of a structurally diverse duplication block triggers recurrent genomic amplification  Nucleic Acids Res  2021  49(1):244-256  PubMed ID: 33290559   DOI: 10.1093/nar/gkaa1136

17857  Akagawa R, Trinh HT, Saha LK, Tsuda M, Hirota K, Yamada S, Shibata A, Kanemaki MT, Nakada S, Takeda S, Sasanuma H.  UBC13-Mediated Ubiquitin Signaling Promotes Removal of Blocking Adducts from DNA Double-Strand Breaks  iScience  2020  23(4):101027  PubMed ID: 32283528   DOI: 10.1016/j.isci.2020.101027

17862  Naoto Shimizu, Remi Akagawa, Shunichi Takeda, Hiroyuki Sasanuma  The MRE11 nuclease promotes homologous recombination not only in DNA double-strand break resection but also in post-resection in human TK6 cells  Genome Instability & Disease  2020  1:184-196    DOI: 10.1007/s42764-020-00015-w

17846  Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S.  BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes  Proc Natl Acad Sci U S A  2018  115(45):E10642-E10651  PubMed ID: 30352856   DOI: 10.1073/pnas.1803177115

17839  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.  Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes  Mol Cell  2016  64(3):580-592  PubMed ID: 27814490   DOI: 10.1016/j.molcel.2016.10.011

17849  Takeda S, Hoa NN, Sasanuma H.  The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths  J Radiat Res  2016  57 Suppl 1(Suppl 1):i25-i32  PubMed ID: 27311583   DOI: 10.1093/jrr/rrw034

17830  Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H.  Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines  Genes Cells  2015  20(12):1059-76  PubMed ID: 26525166   DOI: 10.1111/gtc.12310

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