| 利用者成果(英) |
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17821
Inukai K, Kise K, Hayashi Y, Jia W, Muramatsu F, Okamoto N, Konishi H, Akuta K, Kidoya H, Takakura N.
Cancer apelin receptor suppresses vascular mimicry in malignant melanoma
Pathol Oncol Res
2023
29:1610867.
PubMed ID: 36776217
DOI: 10.3389/pore.2023.1610867
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18108
Yamamoto A, Toba M, Takahashi Y, Takakura Y.
Pharmacokinetic Approach for the Elucidation of Elevated Plasma Small Extracellular Vesicle (sEV) Concentration in Cancer
J Pharm Sci
2023
112(7):1967-1974
PubMed ID: 37001861
DOI: 10.1016/j.xphs.2023.03.017
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19606
Bao Y, Qiao Y, Choi JE, Zhang Y, Mannan R, Cheng C, He T, Zheng Y, Yu J, Gondal M, Cruz G, Grove S, Cao X, Su F, Wang R, Chang Y, Kryczek I, Cieslik M, Green MD, Zou W, Chinnaiyan AM.
Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy
Proc Natl Acad Sci U S A .
2023
120(49)
PubMed ID: 38011559
DOI: 10.1073/pnas.2314416120
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21482
Arioka M, Seto-Tetsuo F, Inoue T, Miura K, Ishikane S, Igawa K, Tomooka K, Takahashi-Yanaga F, Sasaguri T.
Differentiation-inducing factor-1 reduces lipopolysaccharide-induced vascular cell adhesion molecule-1 by suppressing mTORC1-S6K signaling in vascular endothelial cells.
Life Sci
2023
PubMed ID: 37981227
DOI: 10.1016/j.lfs.2023.122278
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17533
Liu W, Ota M, Tabushi M, Takahashi Y, Takakura Y.
Development of allergic rhinitis immunotherapy using antigen-loaded small extracellular vesicles
J Control Release
2022
345:433-442
PubMed ID: 35301052
DOI: 10.1016/j.jconrel.2022.03.016
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17695
Aki Yamamoto, Yuki Takahashi, Shinsuke Inuki, Shumpei Nakagawa, Kodai Nakao, Hiroaki Ohno, Masao Doi, Yoshinobu Takakura
The identification of novel small extracellular vesicle (sEV) production modulators using luciferase‐based sEV quantification method
Journal of Extracellular Biology
2022
1
DOI: 10.1002/jex2.62
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20667
Hazekawa M, Nishinakagawa T, Hosokawa M, Ishibashi D.
Development of an Organ-Directed Exosome-Based siRNA-Carrier Derived from Autologous Serum for Lung Metastases and Testing in the B16/BL6 Spontaneous Lung Metastasis Model.
Pharmaceutics
2022
14(4)
PubMed ID: 35456649
DOI: 10.3390/pharmaceutics14040815
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20877
Kobayashi Y, Kitamura S, Takahashi Y, Takakura Y.
Development of Enzymatic Depletion Methods for Preparation of Small Extracellular Vesicles with Long Blood-Circulation Half-Life.
Pharm Res
2022
PubMed ID: 36195822
DOI: 10.1007/s11095-022-03405-9
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14342
Ando H, Emam SE, Kawaguchi Y, Shimizu T, Ishima Y, Eshima K, Ishida T.
Increasing Tumor Extracellular pH by an Oral Alkalinizing Agent Improves Antitumor Responses of Anti-PD-1 Antibody: Implication of Relationships between Serum Bicarbonate Concentrations, Urinary pH, and Therapeutic Outcomes
Biol Pharm Bull
2021
44(6):844-852
PubMed ID: 34078817
DOI: 10.1248/bpb.b21-00076
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14785
Kitai Y, Ishiura M, Saitoh K, Matsumoto N, Owashi K, Yamada S, Muromoto R, Kashiwakura JI, Oritani K, Matsuda T.
CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation
Int Immunol
2021
33(5):273-280
PubMed ID: 33406263
DOI: 10.1093/intimm/dxab002
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20242
Mori T, Hazekawa M, Yoshida M, Nishinakagawa T, Uchida T, Ishibashi D.
Enhancing the anticancer efficacy of a LL-37 peptide fragment analog using peptide-linked PLGA conjugate micelles in tumor cells.
Int J Pharm
2021
120891
PubMed ID: 34324984
DOI: 10.1016/j.ijpharm.2021.120891
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20312
Matsumoto A, Takahashi Y, Ogata K, Kitamura S, Nakagawa N, Yamamoto A, Ishihama Y, Takakura Y.
Phosphatidylserine-deficient small extracellular vesicle is a major somatic cell-derived sEV subpopulation in blood.
iScience
2021
24(8):102839
PubMed ID: 34368655
DOI: 10.1016/j.isci.2021.102839
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20346
Mizukami Y, Takahashi Y, Shimizu K, Konishi S, Takakura Y, Nishikawa M.
Calcium Peroxide-Containing Polydimethylsiloxane-Based Microwells for Inhibiting Cell Death in Spheroids through Improved Oxygen Supply.
Biol Pharm Bull
2021
44(10):1458-1464
PubMed ID: 34602554
DOI: 10.1248/bpb.b21-00269
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12105
Hasegawa T, Takahashi J, Nagasawa S, Doi M, Moriyama A, Iwahashi H.
DNA Strand Break Properties of Protoporphyrin IX by X-Ray Irradiation against Melanoma.
Int J Mol Sci
2020
PubMed ID: 32225109
DOI: 10.3390/ijms21072302
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13029
Matsumoto A, Asuka M, Takahashi Y, Takakura Y.
Antitumor immunity by small extracellular vesicles collected from activated dendritic cells through effective induction of cellular and humoral immune responses.
Biomaterials
2020
PubMed ID: 32422494
DOI: 10.1016/j.biomaterials.2020.120112
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13125
Liu W, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
Development of CD40L-modified tumor small extracellular vesicles for effective induction of antitumor immune response.
Nanomedicine (Lond)
2020
PubMed ID: 32664826
DOI: 10.2217/nnm-2020-0071
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11311
Umakoshi M, Takahashi S, Itoh G, Kuriyama S, Sasaki Y, Yanagihara K, Yashiro M, Maeda D, Goto A, Tanaka M.
Macrophage-mediated transfer of cancer-derived components to stromal cells contributes to establishment of a pro-tumor microenvironment.
Oncogene
2019
PubMed ID: 30459356
DOI: 10.1038/s41388-018-0564-x
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11310
Wang Y, Zenkoh J, Gerelchuluun A, Sun L, Cai S, Li X, Tsuboi K.
Administration of Dendritic Cells and Anti-PD-1 Antibody Converts X-ray Irradiated Tumors Into Effective In situ Vaccines.
Int. J. Radiat. Oncol. Biol. Phys.
2019
PubMed ID: 30458232
DOI: 10.1016/j.ijrobp.2018.11.019
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11317
Yamaguchi-Sekino S, Kira T, Sekino M, Akahane M.
Effects of 7 T static magnetic fields on the expression of biological markers and the formation of bone in rats.
Bioelectromagnetics
2019
PubMed ID: 30466173
DOI: 10.1002/bem.22161
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11504
Harada Y, Kizuka Y, Tokoro Y, Kondo K, Yagi H, Kato K, Inoue H, Taniguchi N, Maruyama I.
N-glycome inheritance from cells to extracellular vesicles in B16 melanomas.
FEBS Lett.
2019
PubMed ID: 30943309
DOI: 10.1002/1873-3468.13377
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11822
Matsumoto A, Takahashi Y, Ariizumi R, Nishikawa M, Takakura Y.
Development of DNA-anchored assembly of small extracellular vesicle for efficient antigen delivery to antigen presenting cells.
Biomaterials
2019
PubMed ID: 31586864
DOI: 10.1016/j.biomaterials.2019.119518
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11859
Emam SE, Selim Abu Lila A, Elsadek NE, Ando H, Shimizu T, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishid T.
Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues.
Eur J Pharm Biopharm
2019
PubMed ID: 31629787
DOI: 10.1016/j.ejpb.2019.10.005
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11926
Moriyama A, Hasegawa T, Jiang L, Iwahashi H, Mori T, Takahashi J.
Screening of X-ray responsive substances for the next generation of radiosensitizers.
Sci Rep
2019
PubMed ID: 31796788
DOI: 10.1038/s41598-019-54649-2
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12390
Clemente N, Argenziano M, Gigliotti CL, Ferrara B, Boggio E, Chiocchetti A, Caldera F, Trotta F, Benetti E, Annaratone L, Ribero S, Pizzimenti S, Barrera G, Dianzani U, Cavalli R, Dianzani C.
Paclitaxel-Loaded Nanosponges Inhibit Growth and Angiogenesis in Melanoma Cell Models
Front Pharmacol
2019
10:776
PubMed ID: 31354491
DOI: 10.3389/fphar.2019.00776
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10680
Arakawa N, Okubo A, Yasuhira S, Takahashi K, Amano H, Akasaka T, Masuda T, Shibazaki M, Maesawa C.
Carnosic acid, an inducer of NAD(P)H quinone oxidoreductase 1, enhances the cytotoxicity of β-lapachone in melanoma cell lines.
Oncol Lett
2018
15:2393-2400
PubMed ID: 29434949
DOI: 10.3892/ol.2017.7618
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10730
Charoenviriyakul C, Takahashi Y, Morishita M, Nishikawa M, Takakura Y.
Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles.
Mol. Pharm.
2018
15:1073-1080
PubMed ID: 29382201
DOI: 10.1021/acs.molpharmaceut.7b00950
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10745
Takahashi J, Murakami M, Mori T, Iwahashi H.
Verification of radiodynamic therapy by medical linear accelerator using a mouse melanoma tumor model.
Sci Rep
2018
8:2728
PubMed ID: 29426920
DOI: 10.1038/s41598-018-21152-z
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10805
Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H.
Effects of cationic liposomes with stearylamine against virus infection.
Int J Pharm
2018
543:311-317
PubMed ID: 29625169
DOI: 10.1016/j.ijpharm.2018.04.001
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10814
Yanaki M, Kobayashi M, Aruga A, Nomura M, Ozaki M.
In Vivo Antitumor Effects of MK615 Led by PD-L1 Downregulation.
Integr Cancer Ther
2018
17(3):646-653
PubMed ID: 29665734
DOI: 10.1177/1534735418766403
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10831
Emam SE, Ando H, Abu Lila AS, Shimizu T, Ukawa M, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Ishida T.
A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research.
Biol. Pharm. Bull.
2018
41:733-742
PubMed ID: 29709910
DOI: 10.1248/bpb.b17-00919
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11141
Matsumoto Y, Furusawa Y, Uzawa A, Hirayama R, Koike S, Ando K, Tsuboi K, Sakurai H.
Antimetastatic Effects of Carbon-Ion Beams on Malignant Melanomas.
Radiat. Res.
2018
190(4):412-423
PubMed ID: 30040045
DOI: 10.1667/RR15075.1
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11224
Emam SE, Ando H, Lila ASA, Shimizu T, Okuhira K, Ishima Y, Mahdy MA, Ghazy FS, Sagawa I, Ishida T.
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways.
Sci Rep
2018
PubMed ID: 30262875
DOI: 10.1038/s41598-018-32861-w
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11248
Charoenviriyakul C, Takahashi Y, Nishikawa M, Takakura Y.
Preservation of exosomes at room temperature using lyophilization.
Int J Pharm
2018
PubMed ID: 30316791
DOI: 10.1016/j.ijpharm.2018.10.032
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4155
Semba T, Sugihara E, Kamoshita N, Ueno S, Fukuda K, Yoshino M, Takao K, Yoshikawa K, Izuhara K, Arima Y, Suzuki M, Saya H.
Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma.
Cancer Sci.
2018
PubMed ID: 29498146
DOI: 10.1111/cas.13554
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4155
Semba T, Sugihara E, Kamoshita N, Ueno S, Fukuda K, Yoshino M, Takao K, Yoshikawa K, Izuhara K, Arima Y, Suzuki M, Saya H.
Periostin antisense oligonucleotide suppresses bleomycin-induced formation of a lung premetastatic niche for melanoma.
Cancer Sci.
2018
PubMed ID: 29498146
DOI: 10.1111/cas.13554
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4156
Hatano T, Yashiro M, Fujikawa H, Motomura H.
C-X-C Motif Ligand 1 (CXCL1) from melanoma cells down-regulates the invasion of their metastatic melanoma cells.
Oncotarget
2018
PubMed ID: 30123429
DOI: 10.18632/oncotarget.25783
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10305
Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Tomooka K, Sasaguri T.
Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion.
Biochem. Pharmacol.
2017
138:31-48
PubMed ID: 28501501
DOI: 10.1016/j.bcp.2017.05.004
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9632
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.
Accelerated growth of B16BL6 tumor in mice through efficient uptake of their own exosomes by B16BL6 cells
Cancer Sci
2017
108(9):1803-1810
PubMed ID: 28667694
DOI: 10.1111/cas.13310
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14641
Matsumoto A, Takahashi Y, Nishikawa M, Sano K, Morishita M, Charoenviriyakul C, Saji H, Takakura Y.
Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages
J Pharm Sci
2017
106(1):168-175.
PubMed ID: 27649887
DOI: 10.1016/j.xphs.2016.07.022
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14710
Morishita M, Takahashi Y, Nishikawa M, Ariizumi R, Takakura Y.
Enhanced Class I Tumor Antigen Presentation via Cytosolic Delivery of Exosomal Cargos by Tumor-Cell-Derived Exosomes Displaying a pH-Sensitive Fusogenic Peptide
Mol Pharm
2017
14(11):4079-4086
PubMed ID: 28977747
DOI: 10.1021/acs.molpharmaceut.7b00760
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14736
Takara K, Eino D, Ando K, Yasuda D, Naito H, Tsukada Y, Iba T, Wakabayashi T, Muramatsu F, Kidoya H, Fukuhara S, Mochizuki N, Ishii S, Kishima H, Takakura N.
Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact
Cell Rep
2017
20(9):2072-2086
PubMed ID: 28854359
DOI: 10.1016/j.celrep.2017.07.080
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9556
Okubo A, Yasuhira S, Shibazaki M, Takahashi K, Akasaka T, Masuda T, Maesawa C.
NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol.
Pigment Cell Melanoma Res
2016
29:309-16
PubMed ID: 26847926
DOI: 10.1111/pcmr.12461
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9861
Morishita M, Takahashi Y, Matsumoto A, Nishikawa M, Takakura Y.
Exosome-based tumor antigens-adjuvant co-delivery utilizing genetically engineered tumor cell-derived exosomes with immunostimulatory CpG DNA.
Biomaterials
2016
111:55-65
PubMed ID: 27723556
DOI: 10.1016/j.biomaterials.2016.09.031
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12917
Takahashi J, Misawa M, Iwahashi H.
Combined treatment with X-ray irradiation and 5-aminolevulinic acid elicits better transcriptomic response of cell cycle-related factors than X-ray irradiation alone
Int J Radiat Biol
2016
92(12):774-789
PubMed ID: 27586078
DOI: 10.1080/09553002.2016.1230240
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13990
Otani K, Naito Y, Sakaguchi Y, Seo Y, Takahashi Y, Kikuta J, Ogawa K, Ishii M.
Cell-cycle-controlled radiation therapy was effective for treating a murine malignant melanoma cell line in vitro and in vivo
Sci Rep
2016
6:30689
PubMed ID: 27480052
DOI: 10.1038/srep30689
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14110
Taki M, Tagami T, Fukushige K, Ozeki T.
Fabrication of nanocomposite particles using a two-solution mixing-type spray nozzle for use in an inhaled curcumin formulation
Int J Pharm
2016
511(1):104-110
PubMed ID: 27374204
DOI: 10.1016/j.ijpharm.2016.06.134
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14155
Drira R, Sakamoto K.
Sakuranetin Induces Melanogenesis in B16BL6 Melanoma Cells through Inhibition of ERK and PI3K/AKT Signaling Pathways
Phytother Res
2016
30(6):997-1002
PubMed ID: 27000529
DOI: 10.1002/ptr.5606
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7158
Drira R, Sakamoto K.
Isosakuranetin, a 4'-O-methylated flavonoid, stimulates melanogenesis in B16BL6 murine melanoma cells.
Life Sci.
2015
143:43-9
PubMed ID: 26524968
DOI: 10.1016/j.lfs.2015.10.009
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16296
Takahashi J, Misawa M, Murakami M, Mori T, Nomura K, Iwahashi H.
5-Aminolevulinic acid enhances cancer radiotherapy in a mouse tumor model
Springerplus
2013
2:602
PubMed ID: 24324921
DOI: 10.1186/2193-1801-2-602
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7721
Watari K, Nakamura M, Fukunaga Y, Furuno A, Shibata T, Kawahara A, Hosoi F, Kuwano T, Kuwano M, Ono M.
The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway.
Int. J. Cancer
2012
131:310-21
PubMed ID: 21826646
DOI: 10.1002/ijc.26356
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15745
Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M.
Thromboxane A₂ receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells
Cancer Sci
2012
103(4):700-7
PubMed ID: 22296266
DOI: 10.1111/j.1349-7006.2012.02200.x
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7656
Fukuda H, Mochizuki S, Abe H, Okano HJ, Hara-Miyauchi C, Okano H, Yamaguchi N, Nakayama M, D'Armiento J, Okada Y.
Host-derived MMP-13 exhibits a protective role in lung metastasis of melanoma cells by local endostatin production.
Br. J. Cancer
2011
105:1615-24
PubMed ID: 22015555
DOI: 10.1038/bjc.2011.431
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