CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2630 : B16F10]

5225 Fan D, Liaw A, Denkins YM, Collins JH, Van Arsdall M, Chang JL, Chakrabarty S, Nguyen D, Kruzel E, Fidler IJ. Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma. J Exp Ther Oncol 2002 2(5):286-97 PubMed ID: 12416032 DOI: 10.1046/j.1359-4117.2002.01053.x

5224 Dong Z, Yoneda J, Kumar R, Fidler IJ. Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor. J Exp Med 1998 188(4):755-63 PubMed ID: 9705957 DOI: 10.1084/jem.188.4.755

5223 Esumi N, Fan D, Fidler IJ. Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res 1991 51(17):4549-56 PubMed ID: 1873799

5221 Hart IR, Talmadge JE, Fidler IJ. Comparative studies on the quantitative analysis of experimental metastatic capacity. Cancer Res 1983 43(1):400-2 PubMed ID: 6291761

5220 Poste G, Doll J, Fidler IJ. Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci U S A 1981 78(10):6226-30 PubMed ID: 6947225 DOI: 10.1073/pnas.78.10.6226

5217 Raz A, Bucana C, McLellan W, Fidler IJ. Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential. Nature 1980 284(5754):363-4 PubMed ID: 7360272 DOI: 10.1038/284363a0

5218 Hart IR, Raz A, Fidler IJ. Effect of cytoskeleton-disrupting agents on the metastatic behavior of melanoma cells. J Natl Cancer Inst 1980 64(4):891-900 PubMed ID: 6929000

5219 Poste G, Doll J, Hart IR, Fidler IJ. In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res 1980 40(5):1636-44 PubMed ID: 7370995

5216 Fidler IJ, Nicolson GL. Tumor cell and host properties affecting the implantation and survival of blood-borne metastatic variants of B16 melanoma. Isr J Med Sci 1978 14(1):38-50 PubMed ID: 632082

5215 Fidler IJ, Bucana C. Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes. Cancer Res 1977 37(11):3945-56 PubMed ID: 908034

5213 Fidler IJ, Gersten DM, Budmen MB. Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity. Cancer Res 1976 36(9 pt.1):3160-5 PubMed ID: 975082

5214 Fidler IJ, Nicolson GL. Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines. J Natl Cancer Inst 1976 57(5):1199-202 PubMed ID: 1003551 DOI: 10.1093/jnci/57.5.1199

5212 Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res 1975 35(1):218-24 PubMed ID: 1109790

824 Fidler IJ. Selection of successive tumour lines for metastasis Nat New Biol 1973 242(118):148-9 PubMed ID: 4512654 DOI: 10.1038/newbio242148a0

547 Riley,V. Enzymatic determination of transmissible replicating factors associated with mouse tumors. Ann N Y Acad Sci 1963 100:762-790 PubMed ID: 13973915

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22391 Katsuki S, Minami K, Oniwa K, Yagi M, Shimizu S, Hamatani N, Takashina M, Kanai T, Ogawa K. Ultra-high dose rate (FLASH) carbon ion irradiation inhibited immune suppressive protein expression on Pan02 cell line. J Radiat Res 2025 PubMed ID: 39724928 DOI: 10.1093/jrr/rrae091

22727 Ibe A, Nakanishi M, Higashimoto K, Muragaki Y, Ehata S. An acidic microenvironment promotes lymphatic metastasis of melanoma by Thy-1 in endothelial cells and integrin αvβ3 in tumor cells. Discov Oncol 2025 16(1):498 PubMed ID: 40205271 DOI: 10.1007/s12672-025-02276-x

22791 Yamane K, Yamaguchi K, Teruya Y, Miyake N, Nakayama Y, Nonaka T, Chikumi H, Yamasaki A. ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity. Int J Mol Sci 2025 26(7) PubMed ID: 40243581 DOI: 10.3390/ijms26072950

22960 Araki M, Kasuya Y, Yoshimoto K, Katada T, Kontani K. Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay. J Biol Chem 2025 301(6):108545 PubMed ID: 40286847 DOI: 10.1016/j.jbc.2025.108545

21583 Sun X, Watanabe T, Oda Y, Shen W, Ahmad A, Ouda R, de Figueiredo P, Kitamura H, Tanaka S, Kobayashi KS. Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I. Proc Natl Acad Sci U S A 2024 121(6):e2310821121 PubMed ID: 38300873 DOI: 10.1073/pnas.2310821121

21626 Nakanishi M, Ibe A, Morishita K, Shinagawa K, Yamamoto Y, Takahashi H, Ikemori K, Muragaki Y, Ehata S. Acid-sensing receptor GPR4 plays a crucial role in lymphatic cancer metastasis. Cancer Sci 2024 PubMed ID: 38410865 DOI: 10.1111/cas.16098

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21979 Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogoh A, Sakaguchi S, Ogawa Y, Arase H. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell 2024 PubMed ID: 39276775 DOI: 10.1016/j.cell.2024.08.025

22318 Ju M, Minami K, Katsuki S, Takenaka W, Tatekawa S, Tamari K, Koizumi M, Takahashi Y, Ogawa K. Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy Anticancer Res 2024 44(8):3295-3306 PubMed ID: 39060064 DOI: 10.21873/anticanres.17148

22683 Cho J, Bejaoui M, Tominaga K, Isoda H. Comparative Analysis of Olive-Derived Phenolic Compounds' Pro-Melanogenesis Effects on B16F10 Cells and Epidermal Human Melanocytes Int J Mol Sci 2024 25(8):4479 PubMed ID: 38674064 DOI: 10.3390/ijms25084479

22816 Shang-Wei Li, Ming-Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.-W. Wu, Horacio Cabra Block Copolymer‐Stabilized Metal–Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near‐Infrared Photothermal Therapy Advanced NanoBiomed Research 2024 4 DOI: 10.1002/anbr.202300107

22843 Zhang Y, Bejaoui M, Linh TN, Arimura T, Isoda H. A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo Cell Commun Signal 2024 22(1):437 PubMed ID: 39261954 DOI: 10.1186/s12964-024-01813-5

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19796 Waku T, Nakada S, Masuda H, Sumi H, Wada A, Hirose S, Aketa I, Kobayashi A. The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation Cell Rep 2023 42(1):111906 PubMed ID: 36640303 DOI: 10.1016/j.celrep.2022.111906

19968 Hu X, Shui Y, Hirano H, Kusano K, Guo WZ, Fujino M, Li XK. PD-L1 antibody enhanced β-glucan antitumor effects via blockade of the immune checkpoints in a melanoma model Cancer Immunol Immunother 2023 72(3):719-731 PubMed ID: 36053290 DOI: 10.1007/s00262-022-03276-4

21052 Zhou S, Yamada R, Sakamoto K. Low energy multiple blue light-emitting diode light Irradiation promotes melanin synthesis and induces DNA damage in B16F10 melanoma cells. PLoS One 2023 18(2):e0281062 PubMed ID: 36730244 DOI: 10.1371/journal.pone.0281062

21056 Chen P, Yang W, Nagaoka K, Huang GL, Miyazaki T, Hong T, Li S, Igarashi K, Takeda K, Kakimi K, Kataoka K, Cabral H. An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors. Adv Sci (Weinh) 2023 e2205139 PubMed ID: 36739605 DOI: 10.1002/advs.202205139

21230 Kawaguchi K, Watanabe M, Furukawa S, Koga K, Kanamori H, Ikemoto MJ, Takashima S, Maeda M, Oh-Hashi K, Hirata Y, Furuta K, Takemori H. Intermittent inhibition of FYVE finger-containing phosphoinositide kinase induces melanosome degradation in B16F10 melanoma cells. Mol Biol Rep 2023 PubMed ID: 37248430 DOI: 10.1007/s11033-023-08536-9

21308 Toyofuku K, Wakabayashi R, Kamiya N, Goto M. Non-Invasive Transdermal Delivery of Antisense Oligonucleotides with Biocompatible Ionic Liquids. ACS Appl Mater Interfaces 2023 PubMed ID: 37405761 DOI: 10.1021/acsami.3c03900

17570 Villareal MO, Chaochaiphat T, Makbal R, Gadhi C, Isoda H. Molecular Analysis of the Melanogenesis Inhibitory Effect of Saponins-Rich Fraction of Argania spinosa Leaves Extract Molecules 2022 27(19):6762 PubMed ID: 36235295 DOI: 10.3390/molecules27196762

17572 Yamasoba D, Kimura I, Nasser H, Morioka Y, Nao N, Ito J, Uriu K, Tsuda M, Zahradnik J, Shirakawa K, Suzuki R, Kishimoto M, Kosugi Y, Kobiyama K, Hara T, Toyoda M, Tanaka YL, Butlertanaka EP, Shimizu R, Ito H, Wang L, Oda Y, Orba Y, Sasaki M, Nagata K, Yoshimatsu K, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Kuramochi J, Seki M, Fujiki R, Kaneda A, Shimada T, Nakada TA, Sakao S, Suzuki T, Ueno T, Takaori-Kondo A, Ishii KJ, Schreiber G, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sawa H, Saito A, Irie T, Tanaka S, Matsuno K, Fukuhara T, Ikeda T, Sato K. Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike Cell 2022 185(12):2103-2115.e19 PubMed ID: 35568035 DOI: 10.1016/j.cell.2022.04.035

17623 Bouhoute M, Amen Y, Bejaoui M, Mizushima AKO, Shimizu K, Isoda H. New Butyroside D from Argan Press Cake Possess Anti-Melanogenesis Effect via MITF Downregulation in B16F10 and HEM Cells Int J Mol Sci 2022 23(24):16021 PubMed ID: 36555664 DOI: 10.3390/ijms232416021

20207 Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H. Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles. Arthritis Rheumatol 2022 PubMed ID: 34164946 DOI: 10.1002/art.41897

20331 Maeda M, Suzuki M, Fuchino H, Tanaka N, Kobayashi T, Isogai R, Batubara I, Iswantini D, Matsuno M, Kawahara N, Koketsu M, Hamamoto A, Takemori H. Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan. J Nat Med 2022 PubMed ID: 34510371 DOI: 10.1007/s11418-021-01565-3

20712 Kondo N, Hirano F, Temma T. Evaluation of 3-Borono-l-Phenylalanine as a Water-Soluble Boron Neutron Capture Therapy Agent. Pharmaceutics 2022 14(5) PubMed ID: 35631692 DOI: 10.3390/pharmaceutics14051106

20781 Uesugi S, Hakozaki M, Kanno Y, Takahashi Y, Shindo K, Kimura KI, Yano A. Anti-melanogenic effect of furanoeremophilanes identified from edible wild plants belonging to the genus Cacalia. Biosci Biotechnol Biochem 2022 PubMed ID: 35867866 DOI: 10.1093/bbb/zbac124

19471 Hu X, Que W, Hirano H, Wang Z, Nozawa N, Ishii T, Ishizuka M, Ito H, Takahashi K, Nakajima M, Tanaka T, Zhu P, Guo WZ, Li XK. 5-Aminolevulinic acid/sodium ferrous citrate enhanced the antitumor effects of programmed cell death-ligand 1 blockade by regulation of exhausted T cell metabolism in a melanoma model Cancer Sci 2021 112(7):2652-2663 PubMed ID: 33934440 DOI: 10.1111/cas.14930

13919 Kaneda-Nakashima K, Zhang Z, Manabe Y, Shimoyama A, Kabayama K, Watabe T, Kanai Y, Ooe K, Toyoshima A, Shirakami Y, Yoshimura T, Fukuda M, Hatazawa J, Nakano T, Fukase K, Shinohara A. α-Emitting cancer therapy using 211 At-AAMT targeting LAT1 Cancer Sci 2021 112(3):1132-1140 PubMed ID: 33277750 DOI: 10.1111/cas.14761

20230 Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M. Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines. Cell Death Dis 2021 12(7):698 PubMed ID: 34257282 DOI: 10.1038/s41419-021-03998-w

15168 Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells Nat Immunol 2021 22(8):947-957 PubMed ID: 34239121 DOI: 10.1038/s41590-021-00967-5

20277 Zhou S, Yotsumoto H, Tian Y, Sakamoto K. α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway. Biochem Biophys Rep 2021 26:100949 PubMed ID: 33665379 DOI: 10.1016/j.bbrep.2021.100949

15279 Maeda M, Suzuki M, Takashima S, Sasaki T, Oh-Hashi K, Takemori H. The new live imagers MitoMM1/2 for mitochondrial visualization Biochem Biophys Res Commun 2021 562:50-54 PubMed ID: 34034093 DOI: 10.1016/j.bbrc.2021.05.040

20323 Mori D, Tsujikawa T, Sugiyama Y, Kotani SI, Fuse S, Ohmura G, Arai A, Kawaguchi T, Hirano S, Mazda O, Kishida T. Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors. Int J Cancer 2021 PubMed ID: 34460096 DOI: 10.1002/ijc.33786

20370 Jo JI, Emi T, Tabata Y. Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect. Pharmaceutics 2021 13(10) PubMed ID: 34684017 DOI: 10.3390/pharmaceutics13101724

15709 Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y. Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis J Clin Invest 2021 131(17):e139933 PubMed ID: 34623325 DOI: 10.1172/JCI139933

16045 Fardous J, Omoso Y, Joshi A, Yoshida K, Patwary MKA, Ono F, Ijima H. Development and characterization of gel-in-water nanoemulsion as a novel drug delivery system Mater Sci Eng C Mater Biol Appl 2021 124:112076 PubMed ID: 33947568 DOI: 10.1016/j.msec.2021.112076

16057 Morikura T, Miyata S. Mechanical Intermittent Compression Affects the Progression Rate of Malignant Melanoma Cells in a Cycle Period-Dependent Manner Diagnostics (Basel) 2021 11(6):1112 PubMed ID: 34207144 DOI: 10.3390/diagnostics11061112

16127 Kobayashi M, Kojima K, Murayama K, Amano Y, Koyama T, Ogama N, Takeshita T, Fukuhara T, Tanaka N. MK-6, a novel not-α IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance Cancer Sci 2021 112(11):4478-4489 PubMed ID: 34545658 DOI: 10.1111/cas.15127

16276 Shibuya T, Kamiyama A, Sawada H, Kikuchi K, Maruyama M, Sawado R, Ikeda N, Asano K, Kurotaki D, Tamura T, Yoneda A, Imada K, Satoh T, Akira S, Tanaka M, Yotsumoto S. Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor Front Immunol 2021 12:663115 PubMed ID: 34163472 DOI: 10.3389/fimmu.2021.663115

16871 Myra O. Villareal, Meriem Bejaoui, Thanyanan Chaochaiphat, Kozo Sato, Hiroko Isoda Tara (Caesalpinia spinosa L.) tannin promotes proliferation and expression of hair growth-associated markers in human follicular dermal papilla cells Euro-Mediterranean Journal for Environmental Integration 2021 6 DOI: 10.1007/s41207-021-00273-4

17028 Moshikur RM, Ali MK, Wakabayashi R, Moniruzzaman M, Goto M. Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy Int J Pharm 2021 608:121129 PubMed ID: 34562557 DOI: 10.1016/j.ijpharm.2021.121129

21930 Zhou S, Riadh D, Sakamoto K. Grape Extract Promoted α-MSH-Induced Melanogenesis in B16F10 Melanoma Cells, Which Was Inverse to Resveratrol Molecules 2021 26(19):5959 PubMed ID: 34641503 DOI: 10.3390/molecules26195959

19236 Takashi Kitamura, Saori Shiroshita, Daisuke Takahashi, Kazunobu Toshima 2‐Naphthol Moiety of Neocarzinostatin Chromophore as a Novel Protein‐Photodegrading Agent and Its Application as a H2O2‐Activatable Photosensitizer Chemistry – A European Journal 2020 26:14351-14358 DOI: 10.1002/chem.202000833

11949 Kozaka S, Tahara Y, Wakabayashi R, Nakata T, Ueda T, Kamiya N, Goto M. Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier. Mol. Pharm. 2020 PubMed ID: 31833775 DOI: 10.1021/acs.molpharmaceut.9b01104

12095 Baba K, Nomura M, Ohashi S, Hiratsuka T, Nakai Y, Saito T, Kondo Y, Fukuyama K, Kikuchi O, Yamada A, Matsubara J, Hirohashi K, Mitani Y, Mizumoto A, Muto M. Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect. Am J Cancer Res 2020 PubMed ID: 32195019

12122 Makbal R, Villareal MO, Gadhi C, Hafidi A, Isoda H. Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation. Int J Mol Sci 2020 PubMed ID: 32268492 DOI: 10.3390/ijms21072539

12174 Myra O. Villareal, Thanyanan Chaochaiphat, Meriem Bejaoui, Kozo Sato, Hiroko Isoda Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression Planta Medica International Open 2020 DOI: 10.1055/a-1141-0151

12201 Irmanida Batubara, Rika Indri Astuti, Muhammad Eka Prastya, Auliya Ilmiawati, Miwa Maeda, Mayu Suzuki, Akie Hamamoto, Hiroshi Takemori The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level Antioxidants (Basel) 2020 9(8):719 PubMed ID: 32784463 DOI: 10.3390/antiox9080719

13040 Li K, Sun S, Kageyama M, Xiao L, Xing G, Gao R, You F, Fu X, Zhang Z. Evaluation of the Immunomodulatory and Anti-Inflammatory Activities of Honey Bee Larva Powder. J Med Food 2020 PubMed ID: 32456573 DOI: 10.1089/jmf.2019.4554

13388 Zhou S, Sakamoto K. Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway. PLoS One 2020 PubMed ID: 33332393 DOI: 10.1371/journal.pone.0243565

13500 Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, Sato H. Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice Int J Cancer 2020 147(11):3224-3235 PubMed ID: 32818320 DOI: 10.1002/ijc.33262

13558 Bejaoui M, Villareal MO, Isoda H. 3,4,5-Tri- O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes Front Cell Dev Biol 2020 8:175. PubMed ID: 32269993 DOI: 10.3389/fcell.2020.00175

14503 The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays Foods 2020 9(1):73 PubMed ID: 31936516 DOI: 10.3390/foods9010073

11294 Zhou S, Sakamoto K. Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways. Genes Cells 2019 PubMed ID: 30417494 DOI: 10.1111/gtc.12654

11549 Chowdhury MR, Moshikur RM, Wakabayashi R, Tahara Y, Kamiya N, Moniruzzaman M, Goto M. In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations. Int J Pharm 2019 PubMed ID: 31077761 DOI: 10.1016/j.ijpharm.2019.05.020

11612 Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A. Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve. Genes Cells 2019 PubMed ID: 31234244 DOI: 10.1111/gtc.12712

11645 Yamada H, Hakozaki M, Uemura A, Yamashita T. Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells. J. Lipid Res. 2019 PubMed ID: 31345992 DOI: 10.1194/jlr.M090712

11698 Kazuomi Sato, Yuji Yamaguchi, Setsuko Sakaki, Hiroyuki Takenaka Pleurochrysis carterae Hot-Water Extract Inhibits Melanogenesis in Murine Melanoma Cells Cosmetics 2019 DOI: 10.3390/cosmetics6040060

11795 Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A. Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells. Genes Cells 2019 PubMed ID: 31495058 DOI: 10.1111/gtc.12719

11828 Morikura T, Miyata S. Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device. Micromachines (Basel) 2019 PubMed ID: 31575066 DOI: 10.3390/mi10100666

17901 Kageyama M, Li K, Sun S, Xing G, Gao R, Lei Z, Zhang Z. Anti-tumor and anti-metastasis activities of honey bee larvae powder by suppressing the expression of EZH2 Biomed Pharmacother 2018 105:690-696 PubMed ID: 29906747 DOI: 10.1016/j.biopha.2018.06.034

4074 Kazue Mizuno et al Plasma-Induced Suppression of Recurrent and Reinoculated Melanoma Tumors in Mice IEEE Transactions on Radiation and Plasma Medical Sciences 2018 2:353 - 359 DOI: 10.1109/TRPMS.2018.2809673

4151 Manome Y, Suzuki D, Mochizuki A, Saito E, Sasa K, Yoshimura K, Inoue T, Takami M, Inagaki K, Funatsu T, Kamijo R. The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages. Oncotarget 2018 PubMed ID: 30042824 DOI: 10.18632/oncotarget.25711

4158 Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A. Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice. Cancer Chemother. Pharmacol. 2018 PubMed ID: 29869202 DOI: 10.1007/s00280-018-3616-6

4470 Villareal MO, Sato Y, Matsuyama K, Isoda H. Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo. BMC Cancer 2018 18(1):856 PubMed ID: 30157785 DOI: 10.1186/s12885-018-4693-y

14897 Wakabayashi R, Sakuragi M, Kozaka S, Tahara Y, Kamiya N, Goto M. Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma Mol Pharm 2018 15(3):955-961 PubMed ID: 29397746 DOI: 10.1021/acs.molpharmaceut.7b00894

10617 Villareal MO, Kume S, Neffati M, Isoda H. Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes. Biomed Res Int 2017 2017:8303671 PubMed ID: 29359158 DOI: 10.1155/2017/8303671

4527 Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Yoshikazu Yonei Inhibition of AGE-induced Melanogenesis in B16 Melanoma Cells by Iridoid-containing Plants Glycative Stress Research 2017 4 (1): 067-070 DOI: 10.24659/gsr.4.1_067

13481 Gunarta IK, Li R, Nakazato R, Suzuki R, Boldbaatar J, Suzuki T, Yoshioka K. Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells Cancer Sci 2017 108(8):1602-1611 PubMed ID: 28635133 DOI: 10.1111/cas.13294

14635 Sato K, Takei M, Iyota R, Muraoka Y, Nagashima M, Yoshimura Y. Indomethacin inhibits melanogenesis via down-regulation of Mitf mRNA transcription Biosci Biotechnol Biochem 2017 81(12):2307-2313 PubMed ID: 29090638 DOI: 10.1080/09168451.2017.1394812

14722 Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages Proc Natl Acad Sci U S A 2017 114(35):E7331-E7340 PubMed ID: 28808017 DOI: 10.1073/pnas.1708598114

10866 Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor Journal of Drug Delivery Science and Technology 2016 33, 143-148 DOI: 10.1016/j.jddst.2016.04.001

19428 Matsuzaki T, Ito K, Masuda K, Kakinuma E, Sakamoto R, Iketaki K, Yamamoto H, Suganuma M, Kobayashi N, Nakabayashi S, Tanii T, Yoshikawa HY. Quantitative Evaluation of Cancer Cell Adhesion to Self-Assembled Monolayer-Patterned Substrates by Reflection Interference Contrast Microscopy J Phys Chem B 2016 120(7):1221-7 PubMed ID: 26845066 DOI: 10.1021/acs.jpcb.5b11870

10926 Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Shoichi Yamagishi, Yoshikazu Yonei Melanin synthesis induction by advanced glycation end-products (AGEs) without α-melanocyte stimulating hormone (α-MSH) or UV exposure Glycative Stress Research 2016 3 : 229-235 DOI: 10.24659/gsr.3.4_229

12625 Nishio T, Usami M, Awaji M, Shinohara S, Sato K. Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis Mol Cell Biochem 2016 412(1-2):101-10 PubMed ID: 26699907 DOI: 10.1007/s11010-015-2613-x

12841 Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ. Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells Oncotarget 2016 7(31):48860-48869. PubMed ID: 27384490 DOI: 10.18632/oncotarget.10379

14583 Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N. Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease Lab Invest 2016 96(4):468-80 PubMed ID: 26808709 DOI: 10.1038/labinvest.2015.166

7375 Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY. Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci 2015 16:8772-88 PubMed ID: 25903150 DOI: 10.3390/ijms16048772

5420 Katoh D, Nishizuka M1, Osada S1, Imagawa M1. Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity. PLoS One 2015 10(2):e0117197 PubMed ID: 25671570 DOI: 10.1371/journal.pone.0117197

15155 Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ. TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN Eur J Immunol 2015 45(4):1159-69 PubMed ID: 25529558 DOI: 10.1002/eji.201445132

18179 Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T. Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses Elife 2014 3:e04177 PubMed ID: 25149452 DOI: 10.7554/eLife.04177

17093 Fujiwara S, Nagai H, Shimoura N, Oniki S, Yoshimoto T, Nishigori C. Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist J Invest Dermatol 2014 134(7):1884-1892 PubMed ID: 24468748 DOI: 10.1038/jid.2014.42

17122 Ichikawa H, Uneme T, Andoh T, Arita Y, Fujimoto T, Suzuki M, Sakurai Y, Shinto H, Fukasawa T, Fujii F, Fukumori Y. Gadolinium-loaded chitosan nanoparticles for neutron-capture therapy: Influence of micrometric properties of the nanoparticles on tumor-killing effect Appl Radiat Isot 2014 88:109-13 PubMed ID: 24462286 DOI: 10.1016/j.apradiso.2013.12.018

13480 Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells J Vet Med Sci 2012 74(5):545-51 PubMed ID: 22146339 DOI: 10.1292/jvms.11-0464

16183 Ozasa R, Ohno J, Iwahashi T, Taniguchi K. Tumor-induced lymphangiogenesis in cervical lymph nodes in oral melanoma-bearing mice J Exp Clin Cancer Res 2012 31(1):83 PubMed ID: 23031500 DOI: 10.1186/1756-9966-31-83

18581 Fujimoto T, Andoh T, Sudo T, Fujita I, Imabori M, Moritake H, Sugimoto T, Sakuma Y, Takeuchi T, Sonobe H, Epstein AL, Akisue T, Kirihata M, Kurosaka M, Fukumori Y, Ichikawa H. Evaluation of BPA uptake in clear cell sarcoma (CCS) in vitro and development of an in vivo model of CCS for BNCT studies Appl Radiat Isot 2011 69(12):1713-6 PubMed ID: 21354804 DOI: 10.1016/j.apradiso.2011.02.006

18664 Nishisho T, Hata K, Nakanishi M, Morita Y, Sun-Wada GH, Wada Y, Yasui N, Yoneda T. The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells Mol Cancer Res 2011 9(7):845-55 PubMed ID: 21669964 DOI: 10.1158/1541-7786.MCR-10-0449