Back Back
RCB2280 : HCE-T  update : 2019/01/09
CommentSV40-Adeno vector transformed cornea cells. 64kD keratin producing. Choleratoxin-free medium.
Comment from the depositor
Terms and conditions1) In publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Invest Ophthalmol Vis Sci. 1995;36:614-621)
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Araki-Sasaki Kaoru
Originator Araki-Sasaki Kaoru
Year of deposit 2005
Original cell RCB1384
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 49 years
Tissue cornea
Case history maxillary sinus carcinoma
Classification transformed
Recombinant recombinant
Exogene SV40-large T
Memo_1 Mycoplasma was eliminated with MC-210 by the depositor.
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 5% FBS + 5μg/ml Insulin + 10ng/ml human EGF + 0.5% DMSO
Antibiotics Free
Passage method 0.25% trypsin or (0.25% trypsin + 0.02% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 3
User's Publication 104

To topTop
2263  An SV40-immortalized human corneal epithelial cell line and its characterization.  Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H  Invest Ophthalmol Vis Sci  1995  36:614-21  PubMed ID: 7534282
2262  Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells.  Zhang Y, Araki-Sasaki K, Handa H, Akhtar, R A  Curr Eye Res  1995  14:563-71  PubMed ID: 7587302
2261  Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector.  Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang, X Z, Hosaka Y, Aizawa S, Handa H  Invest Ophthalmol Vis Sci  1993  34:2665-71  PubMed ID: 7688358

To topTop
User's Publication
7260  Effect of Keratocyte Supernatant on Epithelial Cell Migration and Proliferation After Corneal Crosslinking (CXL).  Wu MF, Stachon T, Wang J, Song X, Colanesi S, Seitz B, Wagenpfeil S, Langenbucher A, Szentmary N.  Curr. Eye Res.  2015  41:466-73  PubMed ID: 26236938
7396  Evaluation of cationic nanosystems with melatonin using an eye-related bioavailability prediction model.  Hafner A, Lovri? J, Romi? MD, Jureti? M, Pepi? I, Cetina-?i?mek B, Filipovi?-Gr?i? J.  Eur J Pharm Sci  2015  75:142-50  PubMed ID: 25869457
7500  Upregulation of P-glycoprotein expression by ophthalmic drugs in different corneal in-vitro models.  Verstraelen J, Reichl S.  J. Pharm. Pharmacol.  2015  67:605-15  PubMed ID: 25643948
7623  Cellular response of limbal epithelial cells on electrospun poly-ε-caprolactone nanofibrous scaffolds for ocular surface bioengineering: a preliminary in vitro study.  Sharma S, Mohanty S, Gupta D, Jassal M, Agrawal AK, Tandon R.  Mol. Vis.  2011  17:2898-910  PubMed ID: 22128237
7815  Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.  Kato M, Hagiwara Y, Oda T, Imamura-Takai M, Aono H, Nakamura M.  J Ocul Pharmacol Ther  2011  27:353-60  PubMed ID: 21574866
7894  A new method of high-speed cellular protein separation and insight into subcellular compartmentalization of proteins.  Png E, Lan W, Lazaroo M, Chen S, Zhou L, Tong L.  Anal Bioanal Chem  2011  400:767-75  PubMed ID: 21380751
7974  In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells.  Youn HY, McCanna DJ, Sivak JG, Jones LW.  Mol. Vis.  2011  17:237-46  PubMed ID: 21270970
8041  HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection.  Shah A, Farooq AV, Tiwari V, Kim MJ, Shukla D.  Mol. Vis.  2010  16:2476-86  PubMed ID: 21139972
8152  Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells.  Png E, Samivelu GK, Yeo SH, Chew J, Chaurasia SS, Tong L.  J. Cell. Physiol.  2011  226:693-9  PubMed ID: 20717931
8445  Per os administered refined olive oil and marine PUFA-rich oils reach the cornea: possible role on oxidative stress through caveolin-1 modulation.  Dutot M, Liang H, Martin C, Rousseau D, Grynberg A, Warnet JM, Rat P.  Nutr Metab (Lond)  2009  6:48  PubMed ID: 19930652
8502  Corneal protection with high-molecular-weight hyaluronan against in vitro and in vivo sodium lauryl sulfate-induced toxic effects.  Pauloin T, Dutot M, Liang H, Chavinier E, Warnet JM, Rat P.  Cornea  2009  28:1032-41  PubMed ID: 19724206
8624  High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.  Pauloin T, Dutot M, Joly F, Warnet JM, Rat P.  Mol. Vis.  2009  15:577-83  PubMed ID: 19325714
8697  Nourish and nurture: development of a nutrient ocular lubricant.  Liu L, Tiffany J, Dang Z, Dart JK, Watson SL, Daniels JT, Geerling G.  Invest. Ophthalmol. Vis. Sci.  2008  50:2932-9  PubMed ID: 19074805
8755  Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.  Dutot M, Liang H, Pauloin T, Brignole-Baudouin F, Baudouin C, Warnet JM, Rat P.  Mol. Vis.  2008  14:889-97  PubMed ID: 18490962
8777  Friction Coefficient Measurement of Hydrogel Materialson Living Epithelial Cells  Alison C. Dunn A Jessica A. Cobb A Ana N. Kantzios A Sung Jin Lee AMalisa Sarntinoranont A Roger Tran-Son-Tay A W. Gregory Sawyer  Tribology Letters  2008  30:13-19 
8783  A novel method for low load friction testing on living cells.  Cobb JA, Dunn AC, Kwon J, Sarntinoranont M, Sawyer WG, Tran-Son-Tay R.  Biotechnol. Lett.  2007  30:801-6  PubMed ID: 18071637
8874  Corneal epitheliotrophic capacity of three different blood-derived preparations.  Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Kasper K, Geerling G.  Invest. Ophthalmol. Vis. Sci.  2006  47:2438-44  PubMed ID: 16723454
9066  An optimised protocol for the production of autologous serum eyedrops.  Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G.  Graefes Arch. Clin. Exp. Ophthalmol.  2005  243:706-14  PubMed ID: 15756576
9075  Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells.  Joo JH, Alpatov R, Munguba GC, Jackson MR, Hunt ME, Sugrue SP.  Mol. Vis.  2005  11:133-42  PubMed ID: 15735603
9344  Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.  Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP.  Invest. Ophthalmol. Vis. Sci.  2003  44:4715-23  PubMed ID: 14578391
9715  Ocular Tolerability of Preservative-Free Tafluprost and Latanoprost: in vitro and in vivo Comparative Study.  Esaki Y, Shimazaki A, Pellinen P.  Open Ophthalmol J  2016  10:146-53  PubMed ID: 27347250
9744  Acute cytotoxic effects of marketed ophthalmic formulations on human corneal epithelial cells.  Hakkarainen JJ, Reinisalo M, Ragauskas S, Seppänen A, Kaja S, Kalesnykas G.  Int J Pharm  2016  511:73-78  PubMed ID: 27374205
9749  Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination.  Fuwa M, Ueda K, Akaishi T, Yamashita N, Kirihara T, Shimazaki A, Mano H, Kawazu K.  PLoS ONE  2016  11:e0158797  PubMed ID: 27383260
9755  Effect of Amniotic Membrane Suspension (AMS) and Amniotic Membrane Homogenate (AMH) on Human Corneal Epithelial Cell Viability, Migration and Proliferation In Vitro.  Wu MF, Stachon T, Langenbucher A, Seitz B, Szentmáry N.  Curr. Eye Res.  2017  42:351-357  PubMed ID: 27420558
9778  Effects of Long-Term Exposure to 60 GHz Millimeter-Wavelength Radiation on the Genotoxicity and Heat Shock Protein (Hsp) Expression of Cells Derived from Human Eye.  Koyama S, Narita E, Shimizu Y, Suzuki Y, Shiina T, Taki M, Shinohara N, Miyakoshi J.  Int J Environ Res Public Health  2016  13:  PubMed ID: 27509516
9779  Twenty Four-Hour Exposure to a 0.12 THz Electromagnetic Field Does Not Affect the Genotoxicity, Morphological Changes, or Expression of Heat Shock Protein in HCE-T Cells.  Koyama S, Narita E, Shimizu Y, Shiina T, Taki M, Shinohara N, Miyakoshi J.  Int J Environ Res Public Health  2016  13:  PubMed ID: 27527204
9821  Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing.  Kim HJ, Kim JY, Lee BH, Choi SH, Rhim H, Kim HC, Ahn SY, Jeong SW, Jang M, Cho IH, Nah SY.  J. Vet. Sci.  2017  18:387-397  PubMed ID: 27586470
9965  Transforming Growth Factor-β Signaling Cascade Induced by Mechanical Stimulation of Fluid Shear Stress in Cultured Corneal Epithelial Cells.  Utsunomiya T, Ishibazawa A, Nagaoka T, Hanada K, Yokota H, Ishii N, Yoshida A.  Invest. Ophthalmol. Vis. Sci.  2016  57:6382-6388  PubMed ID: 27898984
9974  Hydrogels with Lotus Leaf Topography: Investigating Surface Properties and Cell Adhesion.  Santander-Borrego M, Taran E, Shadforth AM, Whittaker AK, Chirila TV, Blakey I.  Langmuir  2017  33:485-493  PubMed ID: 28054787
10034  Encapsulation of Cardamom Essential Oil in Chitosan Nano-composites: In-vitro Efficacy on Antibiotic-Resistant Bacterial Pathogens and Cytotoxicity Studies.  Jamil B, Abbasi R, Abbasi S, Imran M, Khan SU, Ihsan A, Javed S, Bokhari H, Imran M.  Front Microbiol  2016  7:1580  PubMed ID: 27757108
10189  HCE-T cell-based permeability model: A well-maintained or a highly variable barrier phenotype?  Juretić M, Jurišić Dukovski B, Krtalić I, Reichl S, Cetina-Čižmek B, Filipović-Grčić J, Lovrić J, Pepić I.  Eur J Pharm Sci  2017  104:23-30  PubMed ID: 28315467
10251  Protective effects of fluoroquinolones on UV-induced damage of cultured ocular cell lines.  Nishida T, Kuse Y, Mochizuki K, Shimazawa M, Yamamoto T, Hara H.  Eur. J. Pharmacol.  2017  806:59-66  PubMed ID: 28395990
10412  Toll-like receptor 2-mediated NF-kappa B pathway activation in ocular surface epithelial cells.  Hou A, Tin MQ, Tong L.  Eye Vis (Lond)  2017  4:17  PubMed ID: 28706958
10627  Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies.  Beißner N, Zorn-Kruppa M, Reichl S.  Int J Pharm  2018  536:377-387  PubMed ID: 29191484
10824  Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo corneal models.  Juretić M, Cetina-Čižmek B, Filipović-Grčić J, Hafner A, Lovrić J, Pepić I.  Eur J Pharm Sci  2018  120:133-141  PubMed ID: 29702232
10983  Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjo¨gren’s Syndrome  Meng Z, Klinngam W, Edman MC, Hamm-Alvarez SF.  PLoS One  2017  12:e0184781  PubMed ID: 28902875
11118  Oxidative Stress Suppresses Cellular Autophagy in Corneal Epithelium.  Yin Y, Zong R, Bao X, Zheng X, Cui H, Liu Z, Zhou Y.  Invest. Ophthalmol. Vis. Sci.  2018  59(8):3286-3293  PubMed ID: 29971448
11136  Demonstration of P-selectin expression and potential function in human corneal epithelial cells.  Gillies PJ, Richardson NA, Walshe J, Stephenson SA, Dawson RA, Harkin DG.  Exp. Eye Res.  2018  176:196-206  PubMed ID: 30025918
11142  Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.  Marek V, Melik-Parsadaniantz S, Villette T, Montoya F, Baudouin C, Brignole-Baudouin F, Denoyer A.  Free Radic. Biol. Med.  2018  126:27-40  PubMed ID: 30040995
11175  Mechanistic role of transglutaminase-2 in focal adhesions.  Png E, Hou A, Tong L.  Sci Rep  2018  8(1):12370  PubMed ID: 30120307
11291  New Classes of Polycationic Compounds as Preservatives for Ophthalmic Formulations.  von Deylen D, Dreher C, Seidelmann O, Reichl S.  Pharm. Res.  2018    PubMed ID: 30411196
11370  A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells.  Xu P, Kai C, Kawasaki S, Kobayashi Y, Yamamoto K, Tsujikawa M, Hayashi R, Nishida K.  Transl Vis Sci Technol  2018    PubMed ID: 30619650
4084  Suppressive Effects of Catechins in UV-Induced Cytotoxicity of Human Corneal Epithelial Cells  Akiko TOJU, Yuko UDAKA, Mayumi TSUJI, Hideto OYAMADA, Junichiro KIZAKI, Eiji TOMOYORI, Yuji KIUCHI  Showa Univ J Med Sci  2018  3, 73~85 
4191  D-Optimal Design in the Development of Rheologically Improved In Situ Forming Ophthalmic Gel.  Krtalić I, Radošević S, Hafner A, Grassi M, Nenadić M, Cetina-Čižmek B, Filipović-Grčić J, Pepić I, Lovrić J.  J Pharm Sci  2018    PubMed ID: 29421217
4192  DynaMiTES - A dynamic cell culture platform for in vitro drug testing PART 2 - Ocular DynaMiTES for drug absorption studies of the anterior eye.  Beiβner N, Mattern K, Dietzel A, Reichl S.  Eur J Pharm Biopharm  2018    PubMed ID: 28377274
4193  Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells.  Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF.  Int J Mol Sci  2018    PubMed ID: 30423938
4477  Air pollutant particulate matter 2.5 induces dry eye syndrome in mice.  Tan G, Li J, Yang Q, Wu A, Qu DY, Wang Y, Ye L, Bao J, Shao Y.  Sci Rep  2018  8(1):17828  PubMed ID: 30546125
5426  Glucocorticoid action in human corneal epithelial cells establishes roles for corticosteroids in wound healing and barrier function of the eye.  Kadmiel M, Janoshazi A, Xu X, Cidlowski JA.  Exp Eye Res  2016  152:10-33  PubMed ID: 27600171
6274  A novel apoptotic interaction between HSV-1 and human corneal epithelial cells.  Miles D, Athmanathan S, Thakur A, Willcox M.  Curr Eye Res  2003  26(3-4):165-74  PubMed ID: 12815544
6292  The induction and suppression of the apoptotic response of HSV-1 in human corneal epithelial cells.  Miles DH, Thakur A, Cole N, Willcox MD.  Invest Ophthalmol Vis Sci  2007  48(2):789-96  PubMed ID: 17251479
6299  In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride.  Pauloin T, Dutot M, Warnet JM, Rat P.  Eur J Pharm Sci.   2008  34(4-5):263-73  PubMed ID: 18534829
6311  Development of a human corneal epithelium model utilizing a collagen vitrigel membrane and the changes of its barrier function induced by exposing eye irritant chemicals.  Takezawa T, Nishikawa K, Wang PC.  Toxicol In Vitro  2011  25(6):1237-41  PubMed ID: 21641988
6315  Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit model.  Liang H, Baudouin C, Daull P, Garrigue JS, Brignole-Baudouin F.  Mol Vis  2012  18:2195-204  PubMed ID: 22919267
6323  Comparison of the effects of ophthalmic solutions on human corneal epithelial cells using fluorescent dyes.  Xu M, Sivak JG, McCanna DJ.  J Ocul Pharmacol Ther  2013  29(9):794-802  PubMed ID: 23905770
6324  Vitrigel-eye irritancy test method using HCE-T cells.  Yamaguchi H, Kojima H, Takezawa T.  Toxicol Sci  2013  135(2):347-55  PubMed ID: 23872712
6325  Application of cyclic biamperometry to viability and cytotoxicity assessment in human corneal epithelial cells.  Rahimi M, Youn HY, McCanna DJ, Sivak JG, Mikkelsen SR.  Anal Bioanal Chem  2013  405(14):4975-9  PubMed ID: 23443523
6327  Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion.  Tong L, Png E, Aihua H, Yong SS, Yeo HL, Riau A, Mendoz E, Chaurasia SS, Lim CT, Yiu TW, Iismaa SE.  Biochim Biophys Acta.  2013  1833(6):1304-15  PubMed ID: 23466867
6328  Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride  Hiroyoshi Kasai et al  Pharmacology & Pharmacy   2013  4:377-384 
6330  Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells.  Shibata Y, Tanaka Y, Tomita T, Taogoshi T, Kimura Y, Chikama T, Kihira K.  Jpn J Ophthalmol  2014  58(6):522-7  PubMed ID: 25230910
6332  Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles.  Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA.  J Mater Chem B  2014  2(46):8131-8141  PubMed ID: 25530855
6337  Use of the viability reagent PrestoBlue in comparison with alamarBlue and MTT to assess the viability of human corneal epithelial cells.  Xu M, McCanna DJ, Sivak JG.  J Pharmacol Toxicol Methods  2015  71:1-7  PubMed ID: 25464019
6347  Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals.  Yamaguchi H, Kojima H, Takezawa T.  J Appl Toxicol  2016  36(8):1025-37  PubMed ID: 26472347
6348  A fast and reproducible cell- and 96-well plate-based method for the evaluation of P2X7 receptor activation using YO-PRO-1 fluorescent dye.  Rat P, Olivier E, Tanter C, Wakx A, Dutot M.  J Biol Methods  2017  4(1):e64  PubMed ID: 31453224
6350  Fabrication of a Corneal Model Composed of Corneal Epithelial and Endothelial Cells via a Collagen Vitrigel Membrane Functioned as an Acellular Stroma and Its Application to the Corneal Permeability Test of Chemicals.  Yamaguchi H, Takezawa T.  Drug Metab Dispos  2018  46(11):1684-1691  PubMed ID: 29844140
6351  The Effect of Antiamoebic Agents on Viability, Proliferation and Migration of Human Epithelial Cells, Keratocytes and Endothelial Cells, In Vitro.  Shi L, Stachon T, Seitz B, Wagenpfeil S, Langenbucher A, Szentmáry N.  Curr Eye Res.  2018  43(6):725-733  PubMed ID: 29528760
6352  Expression, Regulation, and Effects of Interleukin-17f in the Human Ocular Surface.  Hou A, Tong L.  Ocul Immunol Inflamm  2018  26(7):1069-1077  PubMed ID: 28537453
6353  siRNA-loaded liposomes: Inhibition of encystment of Acanthamoeba and toxicity on the eye surface.  Faber K, Zorzi GK, Brazil NT, Rott MB, Teixeira HF.  Chem Biol Drug Des  2017  90(3):406-416  PubMed ID: 28135787
6355  Expression of glutathione transferases in corneal cell lines, corneal tissues and a human cornea construct.  Kölln C, Reichl S  Int J Pharm  2016  506(1-2):371-81  PubMed ID: 27113863
6356  Cytochrome P450 Activity in Ex Vivo Cornea Models and a Human Cornea Construct.  Kölln C, Reichl S.  J Pharm Sci  2016  105(7):2204-12  PubMed ID: 27212636
6357  Immunomodulatory effects of bone marrow-derived mesenchymal stem cells on pro-inflammatory cytokine-stimulated human corneal epithelial cells.  Wen L, Zhu M, Madigan MC, You J, King NJ, Billson FA, McClellan K, Sutton G, Petsoglou C2  PLoS One.  2014  9(7):e101841  PubMed ID: 25003339
6358  Surface-modified electrospun poly(epsilon-caprolactone) scaffold with improved optical transparency and bioactivity for damaged ocular surface reconstruction.  Sharma S, Gupta D, Mohanty S, Jassal M, Agrawal AK, Tandon R.  Invest Ophthalmol Vis Sci  2014  55(2):899-907  PubMed ID: 24425860
6359  Functional Characterization of the Glucocorticoid Receptor in the Cornea  Mahita Kadmiel, John A Cidlowski  Investigative Ophthalmology & Visual Science  2014  55:5504 
6360  Effects of heat-treatment on plasma rich in growth factors-derived autologous eye drop.  Anitua E, Muruzabal F, De la Fuente M, Merayo-Lloves J, Orive G.  Exp Eye Res  2014  119:27-34  PubMed ID: 24345372
6361  Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies.  Verstraelen J, Reichl S.  Int J Pharm  2013  441(1-2):765-75  PubMed ID: 23069916
6362  In vitro characterization and ex vivo surgical evaluation of human hair keratin films in ocular surface reconstruction after sterilization processing.  Borrelli M, Reichl S, Feng Y, Schargus M, Schrader S, Geerling G.  J Mater Sci Mater Med  2013  24(1):221-30  PubMed ID: 23015265
6363  Evaluation of Eph receptor and ephrin expression within the human cornea and limbus.  Hogerheyde TA, Stephenson SA, Harkin DG, Bray LJ, Madden PW, Woolf MI, Richardson NA.  Exp Eye Res  2013  107:110-20  PubMed ID: 23247085
6364  Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.  Wang N, Zimmerman K, Raab RW, McKown RL, Hutnik CM, Talla V, Tyler MF 4th, Lee JK, Laurie GW.  J Biol Chem.  2013.  288(25):18146-61  PubMed ID: 23640897
6365  Transforming growth factor-β regulates the expression of anosmin (KAL-1) in human retinal pigment epithelial cells.  Raju R, Jian B, Hooks JJ, Nagineni CN.  Cytokine  2013  61(3):724-7  PubMed ID: 23357298
6333  Effect of the sterilization method on the properties of Bombyx mori silk fibroin films.  George KA, Shadforth AM, Chirila TV, Laurent MJ, Stephenson SA, Edwards GA, Madden PW, Hutmacher DW, Harkin DG.  Mater Sci Eng C Mater Biol Appl  2013  33(2):668-74  PubMed ID: 25427472
6366  Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery.  Anitua E, Muruzabal F, Alcalde I, Merayo-Lloves J, Orive G.  Exp Eye Res  2013  115:153-61  PubMed ID: 23872360
6367  Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: the use of copolymerization as a means to functionalize PHEMA sponges.  Paterson SM, Shadforth AM, Shaw JA, Brown DH, Chirila TV, Baker MV.  Mater Sci Eng C Mater Biol Appl  2013  33(8):4917-22  PubMed ID: 24094205
6368  A human hemi-cornea model for eye irritation testing: quality control of production, reliability and predictive capacity.  Engelke M, Zorn-Kruppa M, Gabel D, Reisinger K, Rusche B, Mewes KR.  Toxicol In Vitro  2013  27(1):458-68  PubMed ID: 22902307
6369  Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing.  Hattori M, Shimizu K, Katsumura K, Oku H, Sano Y, Matsumoto K, Yamaguchi Y, Ikeda T.  Graefes Arch Clin Exp Ophthalmol  2012  250(4):557-63  PubMed ID: 2204824
6370  Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).  Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K.  Trans Am Ophthalmol Soc  2012  110:166-77  PubMed ID: 23818740
6371  Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies.  Hahne M, Zorn-Kruppa M, Guzman G, Brandner JM, Haltner-Ukomado E, Wätzig H, Reichl S.  J Pharm Sci  2012  101(8):2976-88  PubMed ID: 22581751
6372  The synthesis and degradation of collagenase-degradable poly(2-hydroxyethyl methacrylate)-based hydrogels and sponges for potential applications as scaffolds in tissue engineering  Stefan M.Paterson et al  Materials Science and Engineering: C   2012  32:2536-2544 
6374  Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.  Yamada T, Ueda T, Ugawa S, Ishida Y, Imayasu M, Koyama S, Shimada S.  Exp Eye Res  2010  90(1):121-9  PubMed ID: 9793539
6376  Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.  Karla PK, Quinn TL, Herndon BL, Thomas P, Pal D, Mitra A.  J Ocul Pharmacol Ther  2009  25(2):121-32  PubMed ID: 19323627
6377  A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability.  Becker U, Ehrhardt C, Schneider M, Muys L, Gross D, Eschmann K, Schaefer UF, Lehr CM.  Altern Lab Anim  2008  36(1):33-44  PubMed ID: 18333713
6378  TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling.  Secker GA, Shortt AJ, Sampson E, Schwarz QP, Schultz GS, Daniels JT.  Exp Cell Res  2008  314(1):131-42  PubMed ID: 17915216
6379  Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9.  Nishikiori N, Sawada N, Ohguro H.  Jpn J Ophthalmol  2008  52(3):195-203  PubMed ID: 18661270
6380  Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells.  Benko S, Tozser J, Miklossy G, Varga A, Kadas J, Csutak A, Berta A, Rajnavolgyi E.  Mol Vis  2008  14:1575-83  PubMed ID: 18769647
6381  Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells.  Ho JH, Chuang CH, Ho CY, Shih YR, Lee OK, Su Y.  Invest Ophthalmol Vis Sci  2007  48(1):27-33  PubMed ID: 17197512
6382  Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.  Gabison EE1, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S.  Am J Pathol  2005  166(1):209-19  PubMed ID: 15632013
6383  Effect of ofloxacin and netilmicin on human corneal and conjunctival cells in vitro.  Papa V, Leonardi A, Getuli C, Pacelli V, Russo P, Milazzo G.  J Ocul Pharmacol Ther  2003  19(6):535-45  PubMed ID: 14733711
11556  Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol.  Fuwa M, Shimazaki A, Mieda M, Yamashita N, Akaishi T, Taniguchi T, Kato M.  Sci Rep  2019    PubMed ID: 31097790
11595  Long-term exposure to a 40-GHz electromagnetic field does not affect genotoxicity or heat shock protein expression in HCE-T or SRA01/04 cells.  Koyama S, Narita E, Suzuki Y, Shiina T, Taki M, Shinohara N, Miyakoshi J.  J. Radiat. Res.  2019    PubMed ID: 31197350
11636  Mesenchymal cells and fluid flow stimulation synergistically regulate the kinetics of corneal epithelial cells at the air-liquid interface.  Kawata K, Aoki S, Futamata M, Yamamoto-Rikitake M, Nakao I, Enaida H, Toda S.  Graefes Arch. Clin. Exp. Ophthalmol.  2019    PubMed ID: 31321523
11661  TAT-surface modified acyclovir-loaded albumin nanoparticles as a novel ocular drug delivery system  Panita Suwannoi, Mullika Chomnawang, Amolnat Tunsirikongkon, Angsuma Phongphisutthinan, Christel C.Müller-Goymann, Narong Sarisuta  Journal of Drug Delivery Science and Technology  2019   
11818  In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery.  Dukovski BJ, Bračko A, Šare M, Pepić I, Lovrić J.  Acta Pharm  2019    PubMed ID: 31639085
4818  A comparative investigation of Bombyx mori silk fibroin hydrogels generated by chemical and enzymatic cross-linking.  Chirila TV, Suzuki S1, Papolla C.  Biotechnol Appl Biochem  2017  64(6):771-781  PubMed ID: 28220960
6948  Effects of Anti-Glaucoma Prostaglandin Ophthalmic Solutions on Cultured Human Corneal Epithelial Cells.  Tong L, Matsuura E, Takahashi M, Nagano T, Kawazu K.  Curr Eye Res  2019  44(8):856-862  PubMed ID: 30884982
6970  Comparison of cytotoxicity between fixed- and unfixed-combination ophthalmic solutions in vitro  Kazuyo Sadamoto, Shingo Nemoto, Akio Kawamura, Masaaki Kurata  Fundamental Toxicological Sciences  2019  6:245-248 
6967  Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing.  Seino S1,, Matsuoka R, Masuda Y, Kunou M, Okada Y, Saika S.  Cutan Ocul Toxicol  2020  39(1):13-20  PubMed ID: 31588814

Back Back Return Top Page