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RCB2144 : LNCap.FGC  update : 2018/08/02
CommentHuman cell line derived from prostate adenocarcinoma. Derived from lymph node metastasis. TKG0603 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Originator Horoszewicz J.S.
Year of deposit 2005
Original cell TKG0603
Animal human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 50 years
Tissue prostate, lymph node meta
Case history prostaric carcinoma
Metastastatic ability Yes
Metastatsd tissue lymph node
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0603)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 4
User's Publication 24

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5114  LNCaP model of human prostatic carcinoma.  Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP.  Cancer Res  1983  3(4):1809-18  PubMed ID: 6831420
5115  A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP).  Gibas Z, Becher R, Kawinski E, Horoszewicz J, Sandberg AA.  Cancer Genet Cytogenet  1984  11(4):399-404  PubMed ID: 6584201
5116  The LNCaP cell line--a new model for studies on human prostatic carcinoma.  Horoszewicz JS, Leong SS, Chu TM, Wajsman ZL, Friedman M, Papsidero L, Kim U, Chai LS, Kakati S, Arya SK, Sandberg AA.  Prog Clin Biol Res  1980  37:115-32  PubMed ID: 384082
5117  Effect of methotrexate-monoclonal anti-prostatic acid phosphatase antibody conjugate on human prostate tumor.  Deguchi T, Chu TM, Leong SS, Horoszewicz JS, Lee CL.  Cancer Res  1986  46(8):3751-5  PubMed ID: 3731053

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User's Publication
7747  Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.  Qin XY, Zaha H, Nagano R, Yoshinaga J, Yonemoto J, Sone H.  Toxicol. Lett.  2011  206:152-7  PubMed ID: 21771643
8419  alpha1,2-Fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer.  Fukushima K, Satoh T, Baba S, Yamashita K.  Glycobiology  2009  20:452-60  PubMed ID: 20008118
9650  Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells.  Ogura T, Tanaka Y, Tamaki H, Harada M.  Int. J. Oncol.  2016  48:2330-8  PubMed ID: 27082738
9862  A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells.  Sakura Y, Tsuboi K, Uyama T, Zhang X, Taoka R, Sugimoto M, Kakehi Y, Ueda N.  Biochim. Biophys. Acta  2016  1861:1951-1958  PubMed ID: 27693242
9868  Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.  Ito H, Yamaguchi N, Onimaru M, Kimura S, Ohmori T, Ishikawa F, Sato J, Ito S, Inoue H.  Oncol Lett  2016  12:4720-4726  PubMed ID: 28105179
10024  Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation.  Matsumura K, Nakata S, Taniguchi K, Ii H, Ashihara E, Kageyama S, Kawauchi A, Yoshiki T.  BMC Cancer  2016  16:748  PubMed ID: 27658708
10057  Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment.  Li X, Wang X, Zhang J, Hanagata N, Wang X, Weng Q, Ito A, Bando Y, Golberg D.  Nat Commun  2017  8:13936  PubMed ID: 28059072
10094  Parasitological and clinical characterization of Simulium neavei-transmitted onchocerciasis in western Uganda.  Fischer P, Kipp W, Bamuhiga J, Binta-Kahwa J, Kiefer A, Büttner DW.  Trop. Med. Parasitol.  1993  44:311-21  PubMed ID: 8134773
10403  CD147-induced cell proliferation is associated with Smad4 signal inhibition.  Qin H, Rasul A, Li X, Masood M, Yang G, Wang N, Wei W, He X, Watanabe N, Li J, Li X.  Exp. Cell Res.  2017  358:279-289  PubMed ID: 28684116
10514  Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1.  Kanayama M, Hayano T, Koebis M, Maeda T, Tabe Y, Horie S, Aiba A.  Prostate  2017  77:1489-1498  PubMed ID: 28905415
10905  Roasted coffee induction of aldo-keto reductase 1C3 expression in LNCaP human prostate cancer cells is associated with Nrf2 activation    Oncology Letters  2016  12, 5321-5326 
11152  Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase.  Kamei H, Noguchi K, Matsuda H, Murata K.  Biol. Pharm. Bull.  2018  41(8):1307-1310  PubMed ID: 30068884
11156  MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.  Ito S, Kayukawa N, Ueda T, Taniguchi H, Morioka Y, Hongo F, Ukimura O.  Biochim Biophys Acta Gene Regul Mech  2018    PubMed ID: 30076933
11160  In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana.  Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O.  J Evid Based Integr Med  2018    PubMed ID: 30088418
11446  Efficient Prostate Cancer Therapy with Tissue-Specific Homing Peptides Identified by Advanced Phage Display Technology.  Wada A, Terashima T, Kageyama S, Yoshida T, Narita M, Kawauchi A, Kojima H.  Mol Ther Oncolytics  2019    PubMed ID: 30788426
4279  CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells.  Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, Fujihara-Iwata A, Hongo F, Okihara K, Ukimura O.  Oncotarget  2018    PubMed ID: 29707137
4534  Synthesis and evaluation of [64Cu]PSMA-617 targeted for prostate-specific membrane antigen in prostate cancer.  Cui C, Hanyu M, Hatori A, Zhang Y, Xie L, Ohya T, Fukada M, Suzuki H, Nagatsu K, Jiang C, Luo R, Shao G, Zhang M, Wang F.  Am J Nucl Med Mol Imaging  2017  7(2):40-52  PubMed ID: 28533936
6398  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629
11507  Understanding the mechanism underlying the acquisition of radioresistance in human prostate cancer cells.  Murata K, Saga R, Monzen S, Tsuruga E, Hasegawa K, Hosokawa Y.  Oncol Lett  2019    PubMed ID: 31186811
11533  Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model.  Saga R, Matsuya Y, Takahashi R, Hasegawa K, Date H, Hosokawa Y.  J. Radiat. Res.  2019    PubMed ID: 31034058
11591  Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity.  Kawatani M, Yamamoto K, Yamada D, Kamiya M, Miyakawa J, Miyama Y, Kojima R, Morikawa T, Kume H, Urano Y.  J. Am. Chem. Soc.  2019    PubMed ID: 31244179
11800  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Sci Rep  2019    PubMed ID: 31520002
11807  Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.  Takagi H, Ii H, Kageyama S, Hanada E, Taniguchi K, Yoshiya T, Chano T, Kawauchi A, Nakata S.  Anticancer Res.  2019    PubMed ID: 31519583
6922  Impact of 18F-PSMA-1007 Uptake in Prostate Cancer Using Different Peptide Concentrations: Preclinical PET/CT Study on Mice.  Soeda F, Watabe T, Naka S, Liu Y, Horitsugi G, Neels OC, Kopka K, Tatsumi M, Shimosegawa E, Giesel FL, Hatazawa J.  J Nucl Med  2019  60(11):1594-1599  PubMed ID: 30902876

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