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細胞番号 : 細胞名
RCB2098 : TE-8  update : 2024/03/08
細胞特性(Comment:英)Human cell line derived from esophageal cancer. Moderately differentiated squamous cell carcinoma. TKG0259 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト食道癌由来細胞株。中分化型扁平上皮癌。 TKG0259 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)1) In publishing the research results to be obtained by use of this cell line, an acknowledgment to the Depositor, Dr. Tetsuro Nishihira is required. 2) There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)1) 研究成果の公表の際には樹立者(西平哲郎先生)への謝辞が必要です。2) 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
樹立者 Nishihira, Tetsuro
寄託日 2005
元の細胞 TKG0259
動物種 _human < Mammals
属名 Homo
種名 sapiens
採取組織 esophagus
病名 Moderately differntiated squamous carcinoma
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0259)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_1766
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 4 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
ウィルス(EBV) (-)
アイソザイム検査 LD, NP
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 0件
Reference(日) 0件
利用者成果(英) 91件
利用者成果(日) 0件

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Reference(英)

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利用者成果(英)
19967  Kawasaki K, Noma K, Kato T, Ohara T, Tanabe S, Takeda Y, Matsumoto H, Nishimura S, Kunitomo T, Akai M, Kobayashi T, Nishiwaki N, Kashima H, Maeda N, Kikuchi S, Tazawa H, Shirakawa Y, Fujiwara T.  PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer  Cancer Immunol Immunother  2023  72(11):3787-3802  PubMed ID: 37668710   DOI: 10.1007/s00262-023-03531-2
21077  Ishibashi Y, Mochizuki S, Horiuchi K, Tsujimoto H, Kouzu K, Kishi Y, Okada Y, Ueno H.  Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation.  Biochim Biophys Acta Mol Basis Dis  2023  1869(5):166669  PubMed ID: 36813090   DOI: 10.1016/j.bbadis.2023.166669
21175  Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L.  Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors.  Signal Transduct Target Ther  2023  8(1):153  PubMed ID: 37041169   DOI: 10.1038/s41392-023-01359-x
21406  Nguyen Vu TH, Kikuchi O, Ohashi S, Saito T, Ida T, Nakai Y, Cao Y, Yamamoto Y, Kondo Y, Mitani Y, Kataoka S, Kondo T, Katada C, Yamada A, Matsubara J, Muto M.  Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma.  Cancer Sci  2023    PubMed ID: 37724648   DOI: 10.1111/cas.15966
21444  Yamada M, Tanaka K, Yamamoto K, Matsumoto H, Yamasaki M, Yamashita K, Makino T, Saito T, Yamamoto K, Takahashi T, Kurokawa Y, Nakajima K, Okada Y, Eguchi H, Doki Y.  Association between circ_0004365 and cisplatin resistance in esophageal squamous cell carcinoma.  Oncol Lett  2023  26(5):467  PubMed ID: 37780544   DOI: 10.3892/ol.2023.14054
17547  Shimizu H, Katsurahara K, Inoue H, Shiozaki A, Kosuga T, Kudou M, Arita T, Konishi H, Komatsu S, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.  NADPH Oxidase 2 Has a Crucial Role in Cell Cycle Progression of Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2022  29(13):8677-8687  PubMed ID: 35972670   DOI: 10.1245/s10434-022-12384-5
17598  Kim S, Kim GH, Park SJ, Kwon CH, I H, Lee MW, Lee BE.  Exosomal MicroRNA Analyses in Esophageal Squamous Cell Carcinoma Cell Lines  J Clin Med  2022  11(15):4426  PubMed ID: 35956043   DOI: 10.3390/jcm11154426
17626  Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome K, Harada K, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Moroishi T, Komohara Y, Sawa T, Baba H.  Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway  Cancer Lett  2022  530:59-67  PubMed ID: 35033591   DOI: 10.1016/j.canlet.2022.01.014
20614  Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O.  Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.  Biochem Biophys Rep  2022  30:101246  PubMed ID: 35330672   DOI: 10.1016/j.bbrep.2022.101246
13104  Yoshida T, Yokobori T, Saito H, Kuriyama K, Kumakura Y, Honjo H, Hara K, Sakai M, Miyazaki T, Obinata H, Erkhem-Ochir B, Gombodorj N, Sohda M, Saeki H, Kuwano H, Shirabe K.  CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 32529269   DOI: 10.1245/s10434-020-08711-3
13383  Sakamoto H, Koma YI, Higashino N, Kodama T, Tanigawa K, Shimizu M, Fujikawa M, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.  Lab Invest  2021  101(3):353-368  PubMed ID: 33311557   DOI: 10.1038/s41374-020-00512-2
20015  Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.  Am J Pathol  2021    PubMed ID: 33460563   DOI: 10.1016/j.ajpath.2021.01.004
20046  Mitsuda M, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33565032   DOI: 10.1245/s10434-021-09659-8
20069  Narusaka T, Ohara T, Noma K, Nishiwaki N, Katsura Y, Kato T, Sato H, Tomono Y, Kikuchi S, Tazawa H, Shirakawa Y, Matsukawa A, Fujiwara T.  Nanog is a promising chemo-resistant stemness marker and therapeutic target by iron chelators for esophageal cancer.  Int J Cancer  2021    PubMed ID: 33662150   DOI: 10.1002/ijc.33544
20071  Matsumoto Y, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33710504   DOI: 10.1245/s10434-021-09752-y
20247  Munekage E, Serada S, Tsujii S, Yokota K, Kiuchi K, Tominaga K, Fujimoto M, Kanda M, Uemura S, Namikawa T, Nomura T, Murakami I, Hanazaki K, Naka T.  A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.  Neoplasia  2021  23(9):939-950  PubMed ID: 34332450   DOI: 10.1016/j.neo.2021.07.006
16095  Liu Y, Baba Y, Ishimoto T, Tsutsuki H, Zhang T, Nomoto D, Okadome K, Yamamura K, Harada K, Eto K, Hiyoshi Y, Iwatsuki M, Nagai Y, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Ohmuraya M, Wang X, Ajani JA, Sawa T, Baba H.  Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma  Br J Cancer  2021  124(5):963-974  PubMed ID: 33299132   DOI: 10.1038/s41416-020-01198-5
16116  Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y.  APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation  Br J Cancer  2021  125(11):1523-1532  PubMed ID: 34599296   DOI: 10.1038/s41416-021-01561-0
16130  Yajima S, Sugawara K, Iwai M, Tanaka M, Seto Y, Todo T.  Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma  Mol Ther Oncolytics  2021  ;23:402-411  PubMed ID: 34853811   DOI: 10.1016/j.omto.2021.10.012
16863  Takaki W, Konishi H, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Fujiwara H, Masuda K, Otsuji E.  Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2021  28(13):8508-8518  PubMed ID: 34185205   DOI: 10.1245/s10434-021-10089-9
12107  Matsubara D, Konishi H, Arita T, Shoda K, Fujita Y, Ogino S, Takao K, Nanishi K, Kosuga T, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E.  Involvement of Intracellular and Extracellular High-Mobility Group Box-1 in the Progression of Esophageal Squamous Cell Carcinoma.  Ann. Surg. Oncol.  2020    PubMed ID: 32221734   DOI: 10.1245/s10434-020-08363-3
13045  Kodama T, Koma YI, Arai N, Kido A, Urakawa N, Nishio M, Shigeoka M, Yokozaki H.  CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.  Lab Invest  2020    PubMed ID: 32457351   DOI: 10.1038/s41374-020-0441-4
13609  Okamoto M, Koma YI, Kodama T, Nishio M, Shigeoka M, Yokozaki H.  Growth Differentiation Factor 15 Promotes Progression of Esophageal Squamous Cell Carcinoma via TGF-β Type II Receptor Activation  Pathobiology  2020  87(2):100-113  PubMed ID: 31896114   DOI: 10.1159/000504394
11491  Shafaee A, Pirayesh Islamian J, Zarei D, Mohammadi M, Nejati-Koshki K, Farajollahi A, Aghamiri SMR, Rahmati Yamchi M, Baradaran B, Asghari Jafarabadi M.  Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism.  Iran J Med Sci  2019    PubMed ID: 30936596  
11432  Kodaira H, Koma YI, Hosono M, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H.  ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma.  Pathol. Int.  2019    PubMed ID: 30758105   DOI: 10.1111/pin.12771
11631  Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.  LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.  Am. J. Pathol.  2019    PubMed ID: 31323188   DOI: 10.1016/j.ajpath.2019.06.006
11897  Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W.  Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.  Nat Commun  2019    PubMed ID: 31700061   DOI: 10.1038/s41467-019-12846-7
12594  Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer  Cancer Sci  2019  110(12):3727-3737  PubMed ID: 31599475   DOI: 10.1111/cas.14214
12596  Son SW, Chau GC, Kim ST, Um SH.  Vacuolar H +-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling  Cells  2019  8(10):1137  PubMed ID: 31554233   DOI: 10.3390/cells8101137
10255  Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, Marunaka Y, Otsuji E.  Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.  J. Gastroenterol.  2018  53:197-207  PubMed ID: 28389731   DOI: 10.1007/s00535-017-1338-x
10734  Wei L, Yan N, Sun L, Bao C, Li D.  Interplay between the NF‑κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy.  Int. J. Mol. Med.  2018  41:2961-2967  PubMed ID: 29393402   DOI: 10.3892/ijmm.2018.3447
10755  Masuike Y, Tanaka K, Makino T, Yamasaki M, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Mori M, Doki Y.  Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis.  PLoS ONE  2018  13:e0193159  PubMed ID: 29447301   DOI: 10.1371/journal.pone.0193159
10798  Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.  Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.  Oncogene  2018  37(26):3471-3484  PubMed ID: 29563607   DOI: 10.1038/s41388-018-0179-2
11229  Hemmatzadeh M, Mohammadi H, Babaie F, Yousefi M, Ebrazeh M, Mansoori B, Shanehbandi D, Baradaran B.  Snail-1 Silencing by siRNA Inhibits Migration of TE-8 Esophageal Cancer Cells Through Downregulation of Metastasis-Related Genes.  Adv Pharm Bull  2018    PubMed ID: 30276140   DOI: 10.15171/apb.2018.051
4355  Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.  Cancer Sci.  2018  109(2):412-421  PubMed ID: 29168598   DOI: 10.1111/cas.13454
4356  Ishibashi O, Akagi I, Ogawa Y, Inui T.  MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway.  Biochem Biophys Res Commun.  2018  501(2):507-513  PubMed ID: 29738771   DOI: 10.1016/j.bbrc.2018.05.025
4357  Kim MJ, Choi SK, Hong SH, Eun JW, Nam SW, Han JW, You JS.  Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal squamous cell carcinoma via modulation of acetylated FOXO1.  Int. J. Oncol.  2018  53(1):395-403  PubMed ID: 29749437   DOI: 10.3892/ijo.2018.4392
4504  Piao L, Yang Z, Jin J, Ni W, Qi W, Xuan Y.  B7H4 is associated with stemness and cancer progression in esophageal squamous cell carcinoma.  Hum. Pathol.  2018  80:152-162  PubMed ID: 29885401   DOI: 10.1016/j.humpath.2018.05.021
4505  Yang Z, Ni W, Cui C, Qi W, Piao L, Xuan Y.  Identification of LETM1 as a marker of cancer stem-like cells and predictor of poor prognosis in esophageal squamous cell carcinoma.  Hum. Pathol.  2018  81:148-156  PubMed ID: 30031102   DOI: 10.1016/j.humpath.2018.07.001
9448  Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii  p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4  Cancer Res  2018  78(21):6107-6120  PubMed ID: 30181180   DOI: 10.1158/0008-5472.CAN-18-1749
14921  Lee TS, Song IH, Shin JI, Park YS, Kim JY, Kim KI, Lee YJ, Kang JH.  PET Imaging Biomarkers of Anti-EGFR Immunotherapy in Esophageal Squamous Cell Carcinoma Models  Cells  2018  7(11):187  PubMed ID: 30373221   DOI: 10.3390/cells7110187
9998  Hijiya N, Shibata T, Daa T, Hamanaka R, Uchida T, Matsuura K, Tsukamoto Y, Nakada C, Iha H, Inomata M, Moriyama M.  Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis.  Pathol. Int.  2017  67:83-90  PubMed ID: 27976824   DOI: 10.1111/pin.12495
10004  Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.  Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development.  Int. J. Oncol.  2017  50:441-447  PubMed ID: 28035351   DOI: 10.3892/ijo.2016.3817
10116  Akagi I, Ishibashi O.  RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.  Genom Data  2017  12:4-6  PubMed ID: 28224081   DOI: 10.1016/j.gdata.2017.02.002
10141  Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.  Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.  Int. J. Cancer  2017  140:2608-2621  PubMed ID: 28233302   DOI: 10.1002/ijc.30666
10213  Hara K, Miyazaki T, Yokobori T, Yoshida T, Kumakura Y, Honjyo H, Sakai M, Sohda M, Fukuchi M, Kuwano H.  Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma.  Anticancer Res.  2017  37:1043-1048  PubMed ID: 28314263   DOI: 10.21873/anticanres.11415
10353  Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.  Tumour Biol.  2017  39:1010428317700409  PubMed ID: 28618928   DOI: 10.1177/1010428317700409
10365  Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.  Oncol Lett  2017  14:1581-1587  PubMed ID: 28789382   DOI: 10.3892/ol.2017.6334
10449  Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M.  Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.  J. Exp. Clin. Cancer Res.  2017  36:101  PubMed ID: 28764725   DOI: 10.1186/s13046-017-0572-7
10561  Li Z, Jin H, Mao G, Wu L, Guo Q.  Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways.  Exp. Cell Res.  2017  361:170-177  PubMed ID: 29054489   DOI: 10.1016/j.yexcr.2017.10.016
10692  Hosono M, Koma YI, Takase N, Urakawa N, Higashino N, Suemune K, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells.  Oncotarget  2017  8:106071-106088  PubMed ID: 29285315   DOI: 10.18632/oncotarget.22526
10954  IM Puspitasari, R Abdulah, M Syamsunarno, H Koyama   Effect of different doses of X-ray irradiation on survival of human esophageal cells  Advances in Biomolecular Medicine  2017  53    DOI: 10.1201/9781315208619-13
10977    Role of HDM2 Gene in Radio-Sensitivity of Esophageal Cancer Cell Lines to Irradiation  Int J Cancer Manag  2017  10:e8950    DOI: 10.5812/ijcm.8950
14217  Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.  SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma  Cancer Res  2017  77(24):6975-6986  PubMed ID: 29042418   DOI: 10.1158/0008-5472.CAN-17-1525
14243  Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.  Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma  Oncotarget  2017  8(11):17921-17935  PubMed ID: 28160546   DOI: 10.18632/oncotarget.14900
14626  Kumakura Y, Rokudai S, Iijima M, Altan B, Yoshida T, Bao H, Yokobori T, Sakai M, Sohda M, Miyazaki T, Nishiyama M, Kuwano H.  Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma  Cancer Sci  2017  108(11):2149-2155  PubMed ID: 28892579   DOI: 10.1111/cas.13394
14630  Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.  Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma  Oncotarget  2017  8(15):24741-24752  PubMed ID: 28445969   DOI: 10.18632/oncotarget.15799
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13973  Takase N, Koma Y, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H.  NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells  Cancer Lett  2016  380(1):47-58  PubMed ID: 27317650   DOI: 10.1016/j.canlet.2016.06.009
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14108  Osako Y, Seki N, Kita Y, Yonemori K, Koshizuka K, Kurozumi A, Omoto I, Sasaki K, Uchikado Y, Kurahara H, Maemura K, Natsugoe S.  Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma  Int J Oncol  2016  49(6):2255-2264  PubMed ID: 27779648   DOI: 10.3892/ijo.2016.3745
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15229  Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H.  Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma  Cancer Med  2015  4(3):437-46  PubMed ID: 25620088   DOI: 10.1002/cam4.401
15232  Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H.  GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways  Lab Invest  2015  95(5):491-503  PubMed ID: 25730371   DOI: 10.1038/labinvest.2015.36
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15822  Ohashi S, Kikuchi O, Tsurumaki M, Nakai Y, Kasai H, Horimatsu T, Miyamoto S, Shimizu A, Chiba T, Muto M.  Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma  PLoS One  2014  9(8):e103126  PubMed ID: 25090101   DOI: 10.1371/journal.pone.0103126
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