CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2097 : TE-4]

21175 Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L. Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors. Signal Transduct Target Ther 2023 8(1):153 PubMed ID: 37041169 DOI: 10.1038/s41392-023-01359-x

16142 Dong X, Chen X, Lu D, Diao D, Liu X, Mai S, Feng S, Xiong G. LncRNA miR205HG hinders HNRNPA0 translation: anti-oncogenic effects in esophageal carcinoma Mol Oncol 2022 16(3):795-812 PubMed ID: 34821009 DOI: 10.1002/1878-0261.13142

20614 Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O. Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer. Biochem Biophys Rep 2022 30:101246 PubMed ID: 35330672 DOI: 10.1016/j.bbrep.2022.101246

20682 Masuda T, Tazawa H, Hashimoto Y, Ieda T, Kikuchi S, Kuroda S, Noma K, Urata Y, Kagawa S, Fujiwara T. Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells. Acta Med Okayama 2022 76(2):203-215 PubMed ID: 35503449 DOI: 10.18926/AMO/63425

16116 Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y. APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation Br J Cancer 2021 125(11):1523-1532 PubMed ID: 34599296 DOI: 10.1038/s41416-021-01561-0

6883 Terayama M, Yamada K, Hagiwara T, Inazuka F, Sezaki T, Igari T, Yokoi C, Nohara K, Soma D, Dohi T, Kawamura Y. Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional downregulation of β-catenin in human esophageal squamous cells. Carcinogenesis 2020 41(7):875-886 PubMed ID: 31738399 DOI: 10.1093/carcin/bgz189

13600 Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K. p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers Biochem Biophys Res Commun 2020 529(3):582-589. PubMed ID: 32736677 DOI: 10.1016/j.bbrc.2020.05.168

11511 Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. Nature 2019 PubMed ID: 30971826 DOI: 10.1038/s41586-019-1103-9

11631 Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E. LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. Am. J. Pathol. 2019 PubMed ID: 31323188 DOI: 10.1016/j.ajpath.2019.06.006

11699 Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H. Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer. Cancer Sci 2019 110(6):1863-1871 PubMed ID: 31012515 DOI: 10.1111/cas.14028

12594 Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H. Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer Cancer Sci 2019 110(12):3727-3737 PubMed ID: 31599475 DOI: 10.1111/cas.14214

12595 Sawayama H, Ogata Y, Ishimoto T, Mima K, Hiyoshi Y, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Baba H. Glucose transporter 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer Cancer Sci 2019 110(5):1705-1714 PubMed ID: 30861255 DOI: 10.1111/cas.13995

10798 Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A. Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug. Oncogene 2018 37(26):3471-3484 PubMed ID: 29563607 DOI: 10.1038/s41388-018-0179-2

11088 Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Jacques SL, Gureasko J, Brach D, Lingaraj T, West K, Smith S, Rioux N, Waters NJ, Tang C, Raimondi A, Munchhof M, Mills JE, Ribich S, Porter Scott M, Kuntz KW, Janzen WP, Moyer M, Smith JJ, Chesworth R, Copeland RA, Boriack-Sjodin PA. Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. PLoS ONE 2018 13(6):e0197372 PubMed ID: 29856759 DOI: 10.1371/journal.pone.0197372

4355 Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation. Cancer Sci. 2018 109(2):412-421 PubMed ID: 29168598 DOI: 10.1111/cas.13454

9448 Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4 Cancer Res 2018 78(21):6107-6120 PubMed ID: 30181180 DOI: 10.1158/0008-5472.CAN-18-1749

13126 Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K. Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer. Cancer Sci 2018 PubMed ID: 30290054 DOI: 10.1111/cas.13824

14921 Lee TS, Song IH, Shin JI, Park YS, Kim JY, Kim KI, Lee YJ, Kang JH. PET Imaging Biomarkers of Anti-EGFR Immunotherapy in Esophageal Squamous Cell Carcinoma Models Cells 2018 7(11):187 PubMed ID: 30373221 DOI: 10.3390/cells7110187

10141 Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Int. J. Cancer 2017 140:2608-2621 PubMed ID: 28233302 DOI: 10.1002/ijc.30666

10353 Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E. Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma. Tumour Biol. 2017 39:1010428317700409 PubMed ID: 28618928 DOI: 10.1177/1010428317700409

10365 Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. Oncol Lett 2017 14:1581-1587 PubMed ID: 28789382 DOI: 10.3892/ol.2017.6334

14217 Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T. SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma Cancer Res 2017 77(24):6975-6986 PubMed ID: 29042418 DOI: 10.1158/0008-5472.CAN-17-1525

14559 Sci Rep MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin 2017 7(1):10932 PubMed ID: 28883406 DOI: 10.1038/s41598-017-10977-9

9656 Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y. Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma. Oncology 2016 90:347-55 PubMed ID: 27082627 DOI: 10.1159/000445323

12618 Kosumi K, Baba Y, Sakamoto A, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H. Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer Int J Cancer 2016 138(2):428-39 PubMed ID: 26240060 DOI: 10.1002/ijc.29714

12663 Song IH, Lee TS, Park YS, Lee JS, Lee BC, Moon BS, An GI, Lee HW, Kim KI, Lee YJ, Kang JH, Lim SM. Immuno-PET Imaging and Radioimmunotherapy of 64Cu-/177Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model J Nucl Med 2016 57(7):1105-11 PubMed ID: 26917708 DOI: 10.2967/jnumed.115.167155

12969 Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I. Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma Oncotarget 2016 7(13):17111-28 PubMed ID: 26958940 DOI: 10.18632/oncotarget.7937

13992 Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H. UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma Oncotarget 2016 7(36):57821-5783 PubMed ID: 27507047 DOI: 10.18632/oncotarget.11067

14119 Park M, Yoon HJ, Kang MC, Kwon J, Lee HW. PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma Tumour Biol 2016 37(10):14217-14224 PubMed ID: 27557627 DOI: 10.1007/s13277-016-5288-3

7382 Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer 2015 15:82 PubMed ID: 25884729 DOI: 10.1186/s12885-015-1065-8

15184 Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H. Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom Anticancer Res 2015 35(9):4617-24 PubMed ID: 26254350

15448 Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W, Ochiai A. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer Cancer Med 2015 4(11):1667-78 PubMed ID: 26336878 DOI: 10.1002/cam4.515

5608 Zhou X, Koizumi Y, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T. Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice Cancer Sci 2015 106(5):635-41 PubMed ID: 25735932 DOI: 10.1111/cas.12651

13765 Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H. Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer Cancer Res 2014 74(2):575-85 PubMed ID: 24272485 DOI: 10.1158/0008-5472.CAN-13-1836

15825 Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment Cancer Sci 2014 105(10):1236-44 PubMed ID: 25154680 DOI: 10.1111/cas.12503

16011 Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, Chen S, Wang Q, Shen X, Xue R, Dong L. Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma Oncotarget 2014 5(16):7183-97 PubMed ID: 25216531 DOI: 10.18632/oncotarget.2293

17149 Yeo SY, Ha SY, Yu EJ, Lee KW, Kim JH, Kim SH. ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, pr Oncotarget 2014 5(23):12260-72 PubMed ID: 25373738 DOI: 10.18632/oncotarget.2630

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