CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2095 : PANC-1]

19678 Fujihashi Y, Jo Kim M, Maneenet J, Awale S. Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation Chem Biodivers 2023 20(9):e202300280 PubMed ID: 37612242 DOI: 10.1002/cbdv.202300280

3301 Yamada T, Okajima F, Ohwada S, Kondo Y Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. Cell Mol Life Sci 1997 53:435-41 PubMed ID: 9176562 DOI: 10.1007/s000180050052

5077 Wu MC, Arimura GK, Yunis AA. Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int J Cancer 1978 22(6):728-33 PubMed ID: 363626 DOI: 10.1002/ijc.2910220615

3459 Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer 1975 15:741-7 PubMed ID: 1140870 DOI: 10.1002/ijc.2910150505

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19802 Yo Kiichi, Koshiro Fukuoka, Anna Kitano, Koya Ishino, Naoyuki Kotoku Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs Molecules 2024 29:1389 DOI: 10.3390/molecules29061389

19817 Miyata S, Ishii T, Kitanaka S. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia Anticancer Res 2024 44(1):49-59 PubMed ID: 38159998 DOI: 10.21873/anticanres.16787

19848 Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Ishii N, Tsukagoshi M, Watanabe A, Harimoto N, Masamune A, Uojima H, Mizokami M, Ito K, Shirabe K. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer Cancer Sci 2024 Feb 6 PubMed ID: 38321872 DOI: 10.1111/cas.16087

21666 Zhang Z, Aoki H, Umezawa K, Kranrod J, Miyazaki N, Oshima T, Hirao T, Miura Y, Seubert J, Ito K, Aoki S. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discov 2024 10(1):166 PubMed ID: 38580661 DOI: 10.1038/s41420-024-01933-4

21692 Tazuma S, Sudo T, Ishikawa A, Yamaguchi A, Shibata Y, Ishida Y, Kuraoka K, Uemura K, Takahashi S, Tashiro H. Effects of transmembrane serine protease 4 on the survival in patients with pancreatic ductal adenocarcinoma undergoing surgery followed by adjuvant chemotherapy. Surg Today 2024 PubMed ID: 38637344 DOI: 10.1007/s00595-024-02824-y

18285 Yamakawa K, Koyanagi-Aoi M, Machinaga A, Kakiuchi N, Hirano T, Kodama Y, Aoi T. Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase Cancer Cell Int 2023 23(1):94 PubMed ID: 37198667 DOI: 10.1186/s12935-023-02928-4

18746 Yoshinobu Kariya, Jianguo Gu, Yukiko Kariya Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit Biomolecules 2023 13(12):1752 PubMed ID: 38136623 DOI: 10.3390/biom13121752

19616 Masuo H, Kubota K, Shimizu A, Notake T, Miyazaki S, Yoshizawa T, Sakai H, Hayashi H, Soejima Y. Increased mitochondria are responsible for the acquisition of gemcitabine resistance in pancreatic cancer cell lines Cancer Sci 2023 114(11):4388-4400 PubMed ID: 37700464 DOI: 10.1111/cas.15962

19617 Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K. Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment Cancer Sci 2023 114(11):4286-4298 PubMed ID: 37688308 DOI: 10.1111/cas.15952

19693 Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K. High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer Int J Clin Oncol 2023 28(7):901-912 PubMed ID: 37119370 DOI: 10.1007/s10147-023-02342-w

19793 Tomohara K, Maneenet J, Ohashi N, Nose T, Fujii R, Kim MJ, Sun S, Awale S. Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach Biol Pharm Bull 2023 46(10):1412-1420 PubMed ID: 37779042 DOI: 10.1248/bpb.b23-00224

21009 Doi Y, Wakana D, Kitaoka S, Sato F, Tanaka E, Takeda H, Hosoe T. Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds. J Nat Med 2023 PubMed ID: 36635416 DOI: 10.1007/s11418-022-01673-8

21044 Yamada T, Tateishi R, Iwai M, Tanaka M, Ijichi H, Sano M, Koike K, Todo T. Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors. Mol Ther Oncolytics 2023 28:31-43 PubMed ID: 36619294 DOI: 10.1016/j.omto.2022.12.001

21057 Masuda M, Asuka T, Terao N, Nishino S, Ikeda S, Takamatsu S, Kondo J, Miyoshi E. Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies. J Biochem 2023 PubMed ID: 36760066 DOI: 10.1093/jb/mvad015

21107 Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S. Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model. J Nat Prod 2023 PubMed ID: 36938707 DOI: 10.1021/acs.jnatprod.3c00019

21138 Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Rep Med 2023 PubMed ID: 37003259 DOI: 10.1016/j.xcrm.2023.100960

21177 Ouchida T, Maeda H, Akamatsu Y, Maeda M, Takamatsu S, Kondo J, Misaki R, Kamada Y, Ueda M, Ueda K, Miyoshi E. The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro. Sci Rep 2023 13(1):6175 PubMed ID: 37061516 DOI: 10.1038/s41598-023-28572-6

21197 Ando H, Eshima K, Ishida T. A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest. Eur J Pharmacol 2023 950:175758 PubMed ID: 37121563 DOI: 10.1016/j.ejphar.2023.175758

21234 Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N. Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation. J Med Chem 2023 PubMed ID: 37257133 DOI: 10.1021/acs.jmedchem.3c00394

21257 Fukuda K, Seki N, Yasudome R, Mitsueda R, Asai S, Kato M, Idichi T, Kurahara H, Ohtsuka T. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma. Genes (Basel) 2023 14(5) PubMed ID: 37239355 DOI: 10.3390/genes14050995

21290 Yamashita M, Kumazoe M, Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H. PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Biochem Biophys Res Commun 2023 672:154-160 PubMed ID: 37354608 DOI: 10.1016/j.bbrc.2023.06.043

21299 Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M. Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma. Cancer Res 2023 OF1-OF12 PubMed ID: 37378549 DOI: 10.1158/0008-5472.CAN-22-3762

21412 Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI Insight 2023 PubMed ID: 37733442 DOI: 10.1172/jci.insight.163022

21462 Baba K, Uemura K, Nakazato R, Ijaz F, Takahashi S, Ikegami K. Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells. Med Mol Morphol 2023 PubMed ID: 37930423 DOI: 10.1007/s00795-023-00373-w

21531 Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. J Pharmacol Sci 2023 153(4):232-242 PubMed ID: 37973221 DOI: 10.1016/j.jphs.2023.10.003

17509 Maneenet J, Tawila AM, Omar AM, Phan ND, Ojima C, Kuroda M, Sato M, Mizoguchi M, Takahashi I, Awale S. Chemical Constituents of Callistemon subulatus and Their Anti-Pancreatic Cancer Activity against Human PANC-1 Cell Line Plants (Basel) 2022 11(19):2466 PubMed ID: 36235333 DOI: 10.3390/plants11192466

17698 Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i> Advances in Microbiology 2022 12:649-670 DOI: 10.4236/aim.2022.1212045

17709 Kimura A, Arai T, Ueno M, Oyama K, Yu H, Yamashita S, Otome Y, Taguchi M. Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis Pharmaceutics 2022 14(11):2400 PubMed ID: 36365217 DOI: 10.3390/pharmaceutics14112400

20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20471 Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M. ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway. Pancreatology 2022 PubMed ID: 34642112 DOI: 10.1016/j.pan.2021.09.012

20558 Kohyama A, Kim MJ, Yokoyama R, Sun S, Omar AM, Phan ND, Meselhy MR, Tsuge K, Awale S, Matsuya Y. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem 2022 54:116563 PubMed ID: 34942553 DOI: 10.1016/j.bmc.2021.116563

16170 Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) ACS Chem Biol 2022 Feb 7. PubMed ID: 35128925 DOI: 10.1021/acschembio.2c00028

20570 Vaes RDW, van Dijk DPJ, Farshadi EA, Olde Damink SWM, Rensen SS, Langen RC. Human pancreatic tumour organoid-derived factors enhance myogenic differentiation. J Cachexia Sarcopenia Muscle 2022 PubMed ID: 35146962 DOI: 10.1002/jcsm.12917

20531 Fujita T, Lin J, Kimishima A, Arai M, Takikawa H, Ogura Y. Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells. Biosci Biotechnol Biochem 2022 PubMed ID: 35157035 DOI: 10.1093/bbb/zbac025

20592 Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M. Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. J Exp Clin Cancer Res 2022 41(1):89 PubMed ID: 35272688 DOI: 10.1186/s13046-022-02301-9

20717 Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T. Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. PLoS One 2022 17(5) PubMed ID: 35617311 DOI: 10.1371/journal.pone.0266620

16760 Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J. Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy Cancer Sci 2022 113(2):576-586 PubMed ID: 34808019 DOI: 10.1111/cas.15209

20774 Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M. Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun 2022 13(1):4063 PubMed ID: 35831322 DOI: 10.1038/s41467-022-31690-w

16849 Nguyen Ngoc Thanh Luan, Takuya Okada, Ruka Arata, Lanke Prudhvi, Moe Miyaguchi, Yuri Kodama, Suresh Awale, Naoki Toyooka Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy Tetrahedron 2022 132931 DOI: 10.1016/j.tet.2022.132931

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20858 Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, Fang L, Seubert JM, Ito K, Aoki S. PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells. Biochem Biophys Res Commun 2022 625:167-173 PubMed ID: 35963163 DOI: 10.1016/j.bbrc.2022.08.004

20976 Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H. Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer 2022 PubMed ID: 36536047 DOI: 10.1038/s41416-022-02106-9

18117 Chao D, Ariake K, Sato S, Ohtsuka H, Takadate T, Ishida M, Masuda K, Maeda S, Miura T, Mitachi K, Yu XJ, Fujishima F, Mizuma M, Nakagawa K, Morikawa T, Kamei T, Unno M. Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer Oncol Rep 2021 45(6):90 PubMed ID: 33846782 DOI: 10.3892/or.2021.8041

13280 Labib PL, Yaghini E, Davidson BR, MacRobert AJ, Pereira SP. 5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies. Transl Oncol 2021 PubMed ID: 33059124 DOI: 10.1016/j.tranon.2020.100886

13355 Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M. Impact of Capicua on Pancreatic Cancer Progression. Ann Surg Oncol 2021 28(6):3198-3207 PubMed ID: 33216264 DOI: 10.1245/s10434-020-09339-z

20018 Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K. The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model. J Surg Res 2021 261:351-360 PubMed ID: 33493887 DOI: 10.1016/j.jss.2020.12.046

20025 Sun S, Kim MJ, Dibwe DF, Omar AM, Athikomkulchai S, Phrutivorapongkul A, Okada T, Tsuge K, Toyooka N, Awale S. Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora. Plants (Basel) 2021 10(2) PubMed ID: 33503922 DOI: 10.3390/plants10020229

20035 Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E. Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. Glycoconj J 2021 38(1):45-54 PubMed ID: 33523362 DOI: 10.1007/s10719-020-09970-8

20094 Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S. Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. Fitoterapia 2021 104901 PubMed ID: 33794305 DOI: 10.1016/j.fitote.2021.104901

20096 Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M. Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential. Pathobiology 2021 1-9 PubMed ID: 33794543 DOI: 10.1159/000514593

20099 Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H. Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells. Anticancer Res 2021 41(4):1733-1744 PubMed ID: 33813377 DOI: 10.21873/anticanres.14938

20164 Sagara A, Nakata K, Yamashita T, Guan W, Zhong P, Matsumoto S, Endo S, Iwamoto C, Shindo K, Ikenaga N, Moriyama T, Ohuchida K, Mizumoto K, Nakamura M. New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth. Pancreatology 2021 PubMed ID: 33965328 DOI: 10.1016/j.pan.2021.04.002

20167 Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N. Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential. Pancreatology 2021 21(3):573-580 PubMed ID: 33541781 DOI: 10.1016/j.pan.2021.01.013

20186 Saito R, Kawaida H, Hosomura N, Amemiya H, Itakura J, Yamamoto A, Takiguchi K, Maruyama S, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Inoue S, Kono H, Ichikawa D. Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression. Ann Surg Oncol 2021 PubMed ID: 34101067 DOI: 10.1245/s10434-021-10250-4

20189 Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer. Int J Radiat Oncol Biol Phys 2021 PubMed ID: 34112559 DOI: 10.1016/j.ijrobp.2021.04.001

14512 Ando H, Eshima K, Ishida T. Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model Biol Pharm Bull 2021 4(2):266-270 PubMed ID: 33518679 DOI: 10.1248/bpb.b20-00825

20254 Sun S, Kim MJ, Omar AM, Duy Phan N, Aoike M, Awale S. GDP Induces PANC-1 Human Pancreatic Cancer Cell Death Preferentially under Nutrient Starvation by Inhibiting PI3K/Akt/mTOR/Autophagy Signaling Pathway. Chem Biodivers 2021 PubMed ID: 34213070 DOI: 10.1002/cbdv.202100389

15289 Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K. Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms J Nat Med 2021 75(3):612-622 PubMed ID: 33813664 DOI: 10.1007/s11418-021-01507-z

20431 Shiozaki A, Konishi T, Kosuga T, Kudou M, Kurashima K, Inoue H, Shoda K, Arita T, Konishi H, Morimura R, Komatsu S, Ikoma H, Toma A, Kubota T, Fujiwara H, Okamoto K, Otsuji E. Roles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells. Int J Oncol 2021 59(4) PubMed ID: 34414448 DOI: 10.3892/ijo.2021.5256

20448 Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T. Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate. Micromachines (Basel) 2021 12(11) PubMed ID: 34832842 DOI: 10.3390/mi12111431

16171 Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion Elife 2021 10:e66721 PubMed ID: 34590580 DOI: 10.7554/eLife.66721

16214 PRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI, TAKAO OHTSUKA Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma Anticancer Res 2021 41(10):4821-4836 PubMed ID: 34593431 DOI: 10.21873/anticanres.15297

16522 Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H. Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth ACS Chem Biol 2021 16(8):1576-1586 PubMed ID: 34296611 DOI: 10.1021/acschembio.1c00480

16701 Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly J Cell Biol 2021 220(2):e202006085 PubMed ID: 33443571 DOI: 10.1083/jcb.202006085

16776 Sijia Sun, Min Jo Kim, Ashraf M. Omar, Nguyen Duy Phan, Suresh Awale (+)-Panduratin A induces PANC-1 human pancreatic cancer cell death preferentially under nutrient starvation by inhibiting PI3K/Akt/mTOR/autophagy signaling pathway Phytomedicine Plus 2021 1:100101 DOI: 10.1016/j.phyplu.2021.100101

16777 Liang C, Fukuda T, Isaji T, Duan C, Song W, Wang Y, Gu J. α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma Biochim Biophys Acta Gen Subj 2021 1865(6):12987 PubMed ID: 33571582 DOI: 10.1016/j.bbagen.2021.129870

16778 Jinno N, Yoshida M, Hayashi K, Naitoh I, Hori Y, Natsume M, Kato A, Kachi K, Asano G, Atsuta N, Sahashi H, Kataoka H. Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer Cancer Sci 2021 112(2):668-678 PubMed ID: 33053268 DOI: 10.1111/cas.14689

16779 Mang D, Roy SR, Zhang Q, Hu X, Zhang Y. Heparan Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration ACS Appl Mater Interfaces 2021 13(15):17236-17242 PubMed ID: 33830729 DOI: 10.1021/acsami.1c00934

11767 Tang R, Kimishima A, Ishida R, Setiawan A, Arai M. Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation. J Nat Med 2020 74(1):153-158 PubMed ID: 31435860 DOI: 10.1007/s11418-019-01357-w

11836 Tachikawa M, Kaneko Y, Ohtsuki S, Uchida Y, Watanabe M, Ohtsuka H, Terasaki T. Targeted Proteomics-Based Quantitative Protein Atlas of Pannexin and Connexin Subtypes in Mouse and Human Tissues and Cancer Cell Lines. J Pharm Sci 2020 109(2):1161-1168 PubMed ID: 31605689 DOI: 10.1016/j.xphs.2019.09.024

6956 Sato M, Matsumoto M, Saiki Y, Alam M, Nishizawa H, Rokugo M, Brydun A, Yamada S, Kaneko MK, Funayama R, Ito M, Kato Y, Nakayama K, Unno M, Igarashi K. BACH1 promotes pancreatic cancer metastasis by repressing epithelial genes and enhancing epithelial-mesenchymal transition. Cancer Res 2020 80(6):1279-1292 PubMed ID: 31919242 DOI: 10.1158/0008-5472.CAN-18-4099

9820 Mai T T Nguyen, Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Suresh Awale 1, Nhan T Nguyen Calosides A-F, Cardenolides From Calotropis gigantea and Their Cytotoxic Activity J Nat Prod 2020 83(2):385-391 PubMed ID: 31967821 DOI: 10.1021/acs.jnatprod.9b00875

11920 Takumi Chinen , Shohei Yamamoto, Yutaka Takeda , Koki Watanabe, Kanako Kuroki , Kaho Hashimoto , Daisuke Takao , Daiju Kitagawa NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells EMBO J 2020 PubMed ID: 31782546 DOI: 10.15252/embj.2019102378

11941 Alexander BE, Sun S, Palframan MJ, Kociok-Köhn G, Dibwe DF, Watanabe S, Caggiano L, Awale S, Lewis SE. Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells. ChemMedChem 2020 PubMed ID: 31821731 DOI: 10.1002/cmdc.201900549

12029 Tang R, Kimishima A, Setiawan A, Arai M. Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation. J Nat Med 2020 PubMed ID: 32002808 DOI: 10.1007/s11418-020-01390-0

12081 Noda S, Chikazawa K, Suzuki Y, Imaizumi Y, Yamamura H. Involvement of the γ1 subunit of the large-conductance Ca²⁺-activated K⁺ channel in the proliferation of human somatostatinoma cells. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 32178873 DOI: 10.1016/j.bbrc.2020.02.176

12159 Ahmed M. Zaher, Jianyu Lin, Masayoshi Arai Cytotoxic Activity of Abietane-Type Diterpenes Isolated From Taxodium distichum Against Cancer Cells Adapted to Nutrient-Starved Conditions SAGE Journals 2020 DOI: 10.1177/1934578X20915298

12994 Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y. Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells. Oncol Rep 2020 PubMed ID: 32627027 DOI: 10.3892/or.2020.7595

13007 Takenaga K, Akimoto M, Koshikawa N, Nagase H. Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model. PLoS One 2020 PubMed ID: 32340025 DOI: 10.1371/journal.pone.0232230

13085 Tang R, Zhou D, Kimishima A, Setiawan A, Arai M. Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation. J Antibiot (Tokyo) 2020 PubMed ID: 32587348 DOI: 10.1038/s41429-020-0340-3

13088 Hirashita T, Hirashita Y, Iwashita Y, Endo Y, Kiyonaga M, Matsumoto S, Hijiya N, Moriyama M, Murakami K, Inomata M. S6 ribosomal protein phosphorylation is associated with malignancy of intraductal papillary mucinous neoplasm of the pancreas. Ann Gastroenterol Surg 2020 PubMed ID: 33005852 DOI: 10.1002/ags3.12367

13192 Tawila AM, Sun S, Kim MJ, Omar AM, Dibwe DF, Awale S. A Triterpene Lactone from Callistemon citrinus Inhibits the PANC-1 Human Pancreatic Cancer Cells Viability through Suppression of Unfolded Protein Response. Chem Biodivers 2020 PubMed ID: 32865330 DOI: 10.1002/cbdv.202000495

13225 Zheng B, Qu J, Ohuchida K, Feng H, Chong SJF, Yan Z, Piao Y, Liu P, Sheng N, Eguchi D, Ohtsuka T, Mizumoto K, Liu Z, Pervaiz S, Gong P, Nakamura M. LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer. Theranostics 2020 PubMed ID: 32929348 DOI: 10.7150/thno.47001

13239 Tanaka T, Okada R, Hozaka Y, Wada M, Moriya S, Satake S, Idichi T, Kurahara H, Ohtsuka T, Seki N. Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes. Cancers (Basel) 2020 PubMed ID: 32977589 DOI: 10.3390/cancers12102731

13308 Miyata S, Nakamura T, Kitanaka S. 3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. Anticancer Res 2020 PubMed ID: 33109561 DOI: 10.21873/anticanres.14644

13335 Abdel-Naime WA, Kimishima A, Setiawan A, Fahim JR, Fouad MA, Kamel MS, Arai M. Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp. Mar Drugs 2020 PubMed ID: 33171814 DOI: 10.3390/md18110555

13450 Haimin Feng, Taiki Moriyama, Kenoki Ohuchida, Nan Sheng, Chika Iwamoto, Koji Shindo, Kengo Shirahane, Naoki Ikenaga, Shuntaro Nagai, Kohei Nakata, Kazuhiro Mizumoto, Masafumi Nakamura N-acetyl Cysteine Induces Quiescent-like Pancreatic Stellate Cells From an Active State and Attenuates Cancer-stroma Interactions Journal of Experimental & Clinical Cancer Research 2020 DOI: 10.21203/rs.3.rs-89408/v1

13611 Ando Y, Ohuchida K, Otsubo Y, Kibe S, Takesue S, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Oda Y, Nakamura M. Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 PLoS One 2020 15(1):e0228015 PubMed ID: 31999765 DOI: 10.1371/journal.pone.0228015

13621 Yahagi H, Yahagi T, Furukawa M, Matsuzaki K. Antiproliferative and Antimigration Activities of Beauvericin Isolated from Isaria sp. on Pancreatic Cancer Cells Molecules 2020 25(19):4586 PubMed ID: 33050002 DOI: 10.3390/molecules25194586

13837 Machihara K, Namba T. Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma Biochem Biophys Res Commun 2020 527(1):289-296 PubMed ID: 32446382 DOI: 10.1016/j.bbrc.2020.04.109

14801 Takeda Y, Yamazaki K, Hashimoto K, Watanabe K, Chinen T, Kitagawa D. The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression J Cell Sci 2020 133(19):jcs241281 PubMed ID: 32878946 DOI: 10.1242/jcs.241281

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

11190 Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix. Int. J. Cancer 2019 144(6):1401-1413 PubMed ID: 30152542 DOI: 10.1002/ijc.31775

11218 Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T. Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas. Oncogene 2019 38(8):1211-1224 PubMed ID: 30250298 DOI: 10.1038/s41388-018-0510-y

11436 Yan Z, Ohuchida K, Zheng B, Okumura T, Takesue S, Nakayama H, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis. J. Cancer Res. Clin. Oncol. 2019 PubMed ID: 30770989 DOI: 10.1007/s00432-019-02860-z

11483 Khalid M, Idichi T, Seki N, Wada M, Yamada Y, Fukuhisa H, Toda H, Kita Y, Kawasaki Y, Tanoue K, Kurahara H, Mataki Y, Maemura K, Natsugoe S. Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation. Cancers (Basel) 2019 PubMed ID: 30866526 DOI: 10.3390/cancers11030327

11480 Fukuhisa H, Seki N, Idichi T, Kurahara H, Yamada Y, Toda H, Kita Y, Kawasaki Y, Tanoue K, Mataki Y, Maemura K, Natsugoe S. Gene regulation by antitumor miR-130b-5p in pancreatic ductal adenocarcinoma: the clinical significance of oncogenic EPS8. J. Hum. Genet. 2019 PubMed ID: 30858505 DOI: 10.1038/s10038-019-0584-6

5027 Nishizawa N1, Harada H1, Kumamoto Y1, Kaizu T, Katoh H, Tajima H, Ushiku H, Yokoi K, Igarashi K, Fujiyama Y, Okuwaki K, Iwai T, Watanabe M, Yamashita K1 Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer. Cancer Sci 2019 110(9):2846-2855 PubMed ID: 31325200 DOI: 10.1111/cas.14134

11571 Nakayama H, Ohuchida K, Yonenaga A, Sagara A, Ando Y, Kibe S, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Shido K, Miyoshi K, Nakata K, Moriyama T, Miyasaka Y, Inoue S, Ohtsuka T, Mizumoto K, Nakamura M. S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer. Int. J. Oncol. 2019 PubMed ID: 31180531 DOI: 10.3892/ijo.2019.4812

11575 Yan Z, Ohuchida K, Fei S, Zheng B, Guan W, Feng H, Kibe S, Ando Y, Koikawa K, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Hashizume M, Nakamura M. Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis. J. Exp. Clin. Cancer Res. 2019 PubMed ID: 31133044 DOI: 10.1186/s13046-019-1226-8

11779 Zhao H, Jiang X, Duan L, Yang L, Wang W, Ren Z. Liraglutide suppresses the metastasis of PANC-1 co-cultured with pancreatic stellate cells through modulating intracellular calcium content. Endocr. J. 2019 PubMed ID: 31474673 DOI: 10.1507/endocrj.EJ19-0215

11811 Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) 2019 11(9):1372 PubMed ID: 31527446 DOI: 10.3390/cancers11091372

11851 Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T. Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction. Sci Rep 2019 PubMed ID: 31611630 DOI: 10.1038/s41598-019-51462-9

6913 Kumaramangalam Jeyalakshmi, et al Highly active copper(I) complexes of aroylthiourea ligands against cancer cells – synthetic and biological studies New J Chem 2019 43:3188 DOI: 10.1039/C8NJ04246B

9414 Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2 CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin Mol Cell Biol 2019 39(16):e00073-19 PubMed ID: 31160493 DOI: 10.1128/MCB.00073-19

11906 Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M. Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells. J Pharm Pharm Sci 2019 PubMed ID: 31804920 DOI: 10.18433/jpps30444

11940 Shiratori R, Furuichi K, Yamaguchi M, Miyazaki N, Aoki H, Chibana H, Ito K, Aoki S. Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner. Sci Rep 2019 PubMed ID: 31822748 DOI: 10.1038/s41598-019-55296-3

10563 Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180. Cancer Lett. 2018 412:143-154 PubMed ID: 29061505 DOI: 10.1016/j.canlet.2017.10.010

11140 Akimoto M, Maruyama R, Kawabata Y, Tajima Y, Takenaga K. Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis. Cell Death Dis 2018 9(8):804 PubMed ID: 30038429 DOI: 10.1038/s41419-018-0851-z

4453 Idichi T, Seki N, Kurahara H, Fukuhisa H, Toda H, Shimonosono M, Yamada Y, Arai T, Kita Y, Kijima Y, Mataki Y, Maemura K, Natsugoe S. Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. Oncotarget 2018 9(48):28849-28865 PubMed ID: 29988949 DOI: 10.18632/oncotarget.25599

4216 Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M. Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction. Cell Commun. Signal 2018 PubMed ID: 30180849 DOI: 10.1186/s12964-018-0262-x

4314 Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Terada K, Itadani M, Okada N, Hassan NMM, Nagatsuka H, Ikeda T, Nohno T, Fujita S. DKK3 Overexpression Increases the Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells. Oncol. Res. 2018 PubMed ID: 28470144 DOI: 10.3727/096504017X14926874596386

4382 Kavatsurwa SM, Lombe BK, Feineis D, Dibwe DF, Maharaj V, Awale S, Bringmann G. Ancistroyafungines A-D, 5,8'- and 5,1'-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells. Fitoterapia 2018 PubMed ID: 30059720 DOI: 10.1016/j.fitote.2018.07.017

4383 Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y. Alternating magnetic field enhances cytotoxicity of Compound C. Cancer Sci. 2018 109(11):3483-3493 PubMed ID: 30155931 DOI: 10.1111/cas.13781

4481 Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Reto Brun, Suresh Awale and Gerhard Bringmann Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells RSC Adv 2018 8:5243 PubMed ID: 35542436 DOI: 10.1039/c8ra00363g

4494 Inoko K, Hiraoka K, Inagaki A, Takahashi M, Kushibiki T, Hontani K, Takano H, Sato S, Takeuchi S, Nakamura T, Tsuchikawa T, Shichinohe T, Gruber HE, Jolly DJ, Kasahara N, Hirano S. Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer. Cancer Gene Ther. 2018 25(7-8):184-195 PubMed ID: 29735994 DOI: 10.1038/s41417-018-0020-7

5802 Eguchi T et al Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment. PLoS One 2018 13(2):e0191109. PubMed ID: 29415026 DOI: 10.1371/journal.pone.0191109

15051 Sun S, Phrutivorapongkul A, Dibwe DF, Balachandran C, Awale S. Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line J Nat Prod 2018 81(8):1877-1883 PubMed ID: 30070833 DOI: 10.1021/acs.jnatprod.8b00405

15052 Fayez S, Feineis D, Aké Assi L, Kaiser M, Brun R, Awale S, Bringmann G. Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells Fitoterapia 2018 131:245-259 PubMed ID: 30419265 DOI: 10.1016/j.fitote.2018.11.006

9761 Arai M, Shin D, Kamiya K, Ishida R, Setiawan A, Kotoku N, Kobayashi M. Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II. J Nat Med 2017 71:44-49 PubMed ID: 27449332 DOI: 10.1007/s11418-016-1025-x

9958 Kumazoe M, Takai M, Bae J, Hiroi S, Huang Y, Takamatsu K, Won Y, Yamashita M, Hidaka S, Yamashita S, Yamada S, Murata M, Tsukamoto S, Tachibana H. FOXO3 is essential for CD44 expression in pancreatic cancer cells. Oncogene 2017 36:2643-2654 PubMed ID: 27893718 DOI: 10.1038/onc.2016.426

10046 Abe T, Ohuchida K, Koikawa K, Endo S, Okumura T, Sada M, Horioka K, Zheng B, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination. Int. J. Oncol. 2017 50:457-467 PubMed ID: 28035373 DOI: 10.3892/ijo.2016.3829

10053 Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN. Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents. Biomater Sci 2017 5:432-443 PubMed ID: 28059418 DOI: 10.1039/c6bm00621c

10086 Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S. Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line. J. Nat. Prod. 2017 80:141-148 PubMed ID: 28099006 DOI: 10.1021/acs.jnatprod.6b00784

10311 Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Kangawa K, Tachibana H. The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J. Biol. Chem. 2017 292:10813-10823 PubMed ID: 28507102 DOI: 10.1074/jbc.M116.772111

10337 Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PLoS ONE 2017 12:e0178221 PubMed ID: 28558031 DOI: 10.1371/journal.pone.0178221

10399 Fujita M, Hasegawa A, Yamamori M, Okamura N. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J. Exp. Clin. Cancer Res. 2017 36:91 PubMed ID: 28673319 DOI: 10.1186/s13046-017-0557-6

10448 Arai MA, Utsumi T, Yanase N, Fujimatsu T, Ishibashi M. Efficient Synthesis of Heterocyclic Flavonoids with Hedgehog Signal Inhibitory Activity. Chem. Pharm. Bull. 2017 65:784-795 PubMed ID: 28768932 DOI: 10.1248/cpb.c17-00305

10481 Endo S, Nakata K, Sagara A, Koikawa K, Ando Y, Kibe S, Takesue S, Nakayama H, Abe T, Okumura T, Moriyama T, Miyasaka Y, Ohuchida K, Ohtsuka T, Mizumoto K, Nakamura M. Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells. Pancreatology 2017 17:990-996 PubMed ID: 28927939 DOI: 10.1016/j.pan.2017.08.009

10537 Kawamura D, Takemoto Y, Nishimoto A, Ueno K, Hosoyama T, Shirasawa B, Tanaka T, Kugimiya N, Harada E, Hamano K. Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells. Oncol. Rep. 2017 38:3238-3244 PubMed ID: 29048622 DOI: 10.3892/or.2017.5974

11010 Ancistrolikokines E–H and related 5,8′-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko with antiausterity activities against PANC-1 human pancreatic cancer cells RSC Adv. 2017 7, 53740-53751 DOI: 10.1039/C7RA11200A

5446 Endo S1, Nakata K2, Ohuchida K3, Takesue S1, Nakayama H1, Abe T1, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C5, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology 2017 152(6):1492-1506 PubMed ID: 28126348 DOI: 10.1053/j.gastro.2017.01.010

9171 Haruhiko Fuwa, Mizuho Sato A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells Mar Drugs 2017 15 (10) PubMed ID: 29053565 DOI: 10.3390/md15100320

14191 Li J, Seupel R, Bruhn T, Feineis D, Kaiser M, Brun R, Mudogo V, Awale S, Bringmann G. Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line J Nat Prod 2017 80(10):2807-2817 PubMed ID: 29043798 DOI: 10.1021/acs.jnatprod.7b00650

14206 Nguyen HX, Nguyen MTT, Nguyen NT, Awale S. Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line J Nat Prod 2017 80(8):2345-2352 PubMed ID: 28783356 DOI: 10.1021/acs.jnatprod.7b00375

14225 Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H. PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma Sci Rep 2017 7(1):1917. PubMed ID: 28507327 DOI: 10.1038/s41598-017-02162-9

14244 Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S. Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma Oncotarget 2017 8(32):53180-53193 PubMed ID: 28881803 DOI: 10.18632/oncotarget.18261

14251 Yonemori K, Seki N, Idichi T, Kurahara H, Osako Y, Koshizuka K, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S. The microRNA expression signature of pancreatic ductal adenocarcinoma by RNA sequencing: anti-tumour functions of the microRNA-216 cluster Oncotarget 2017 8(41):70097-70115 PubMed ID: 29050264 DOI: 10.18632/oncotarget.19591

14252 Maki T, Ikeda H, Kuroda A, Kyogoku N, Yamamura Y, Tabata Y, Abiko T, Tsuchikawa T, Hida Y, Shichinohe T, Tanaka E, Kaga K, Hatanaka K, Matsuno Y, Imai N, Hirano S. Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification Int J Oncol 2017 50(1):129-140. PubMed ID: 27922671 DOI: 10.3892/ijo.2016.3786

14378 Yonemori K, Seki N, Kurahara H, Osako Y, Idichi T, Arai T, Koshizuka K, Kita Y, Maemura K, Natsugoe S. ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma Cancer Sci 2017 108(1):124-135 PubMed ID: 27862697 DOI: 10.1111/cas.13119

14616 Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H. Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression Oncotarget 2017 8(7):12290-12300 PubMed ID: 28103577 DOI: 10.18632/oncotarget.14703

14655 Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion Cancer Res 2017 77(9):2328-2338 PubMed ID: 28202517 DOI: 10.1158/0008-5472.CAN-16-1846

14681 Inaguma S, Wang Z, Lasota J, Onda M, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Pastan I, Miettinen M. Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma Oncotarget 2017 8(16):26744-26754 PubMed ID: 28460459 DOI: 10.18632/oncotarget.15814

14726 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E. Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer Sci Rep 2017 7(1):5708 PubMed ID: 28720759 DOI: 10.1038/s41598-017-06137-8

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