Cell No. : Cell Name RCB1988 : TE-9  update : 2023/01/04
Comment			Human esophageal squamous cell carcinoma (poorly differentiated) cell line. Not transplantable to nude mouse. TKG0260 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditions			1) In publishing the research results to be obtained by use of this cell line, an acknowledgment to the Depositor, Dr. Tetsuro Nishihira is required. 2) There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Obinata, Masuo
		Originator	Nishihira, Tetsuro (Sekine, Y.)
		Year of deposit	2004
		Original cell	TKG0572
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Gender	Male
		Tissue	esophagus, pleural effusion
		Disease name	poorly differentiated squamous carcinoma
		Classification	cancer
		History	Cell Resource Center for Biomedical Research, Tohoku University（TKG0260）
		Lifespan	infinite
		Morphology	epithelial-like
		Cellosaurus(Expasy)	CVCL_1767
			deposit info	lot info
		Medium	Medium List
		Culture type		Adherent cells
		Culture medium		RPMI1640 + 10% FBS
		Antibiotics		Free
		Passage method		0.25% Trypsin
	Culture information	Passage ratio		1 : 8 split
		SC frequency		Subculture : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma		(-)
		Isozyme		LD, NP
		STR(human)		OK
Images			deposit info	lot info
Reference information		Reference	2
		User's Publication	60

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Reference

3174  Hay, Park, Gazdar, Ed.    Atlas of Human Tumor Cell Lines  1994  269-282

3173  Nishihira T, Hashimoto Y, Katayama M, Mori S, Kuroki T  Molecular and cellular features of esophageal cancer cells.  J Cancer Res Clin Oncol  1993  119:441-9  PubMed ID: 8509434   DOI: 10.1007/BF01215923

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User's Publication

21588  Miyako S, Koma YI, Nakanishi T, Tsukamoto S, Yamanaka K, Ishihara N, Azumi Y, Urakami S, Shimizu M, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  Periostin in Cancer-Associated Fibroblasts Promotes Esophageal Squamous Cell Carcinoma Progression by Enhancing Cancer and Stromal Cell Migration.  Am J Pathol  2024    PubMed ID: 38320632   DOI: 10.1016/j.ajpath.2023.12.010

19768  Tsukamoto S, Koma YI, Kitamura Y, Tanigawa K, Azumi Y, Miyako S, Urakami S, Hosono M, Kodama T, Nishio M, Shigeoka M, Yokozaki H.  Matrix Metalloproteinase 9 Induced in Esophageal Squamous Cell Carcinoma Cells via Close Contact with Tumor-Associated Macrophages Contributes to Cancer Progression and Poor Prognosis  Cancers (Basel)  2023  15(11):2987  PubMed ID: 37296952   DOI: 10.3390/cancers15112987

19965  Azumi Y, Koma YI, Tsukamoto S, Kitamura Y, Ishihara N, Yamanaka K, Nakanishi T, Miyako S, Urakami S, Tanigawa K, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α  Cells  2023  12(22):2603  PubMed ID: 37998338   DOI: 10.3390/cells12222603

21054  Kitamura Y, Koma YI, Tanigawa K, Tsukamoto S, Azumi Y, Miyako S, Urakami S, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  Roles of IL-7R Induced by Interactions between Cancer Cells and Macrophages in the Progression of Esophageal Squamous Cell Carcinoma.  Cancers (Basel)  2023  15(2)  PubMed ID: 36672342   DOI: 10.3390/cancers15020394

21175  Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L.  Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors.  Signal Transduct Target Ther  2023  8(1):153  PubMed ID: 37041169   DOI: 10.1038/s41392-023-01359-x

17546  Liu J, Liu ZX, Li JJ, Zeng ZL, Wang JH, Luo XJ, Wong CW, Zheng JB, Pu HY, Mo HY, Sheng H, Wu QN, Li H, Wan G, Li B, Wang DS, Xu RH, Ju HQ.  The macrophage-associated lncRNA MALR facilitates ILF3 liquid-liquid phase separation to promote HIF1α signaling in esophageal cancer  Cancer Res  2022  CAN-22-1922  PubMed ID: 36264156   DOI: 10.1158/0008-5472.CAN-22-1922

17547  Shimizu H, Katsurahara K, Inoue H, Shiozaki A, Kosuga T, Kudou M, Arita T, Konishi H, Komatsu S, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.  NADPH Oxidase 2 Has a Crucial Role in Cell Cycle Progression of Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2022  29(13):8677-8687  PubMed ID: 35972670   DOI: 10.1245/s10434-022-12384-5

17598  Kim S, Kim GH, Park SJ, Kwon CH, I H, Lee MW, Lee BE.  Exosomal MicroRNA Analyses in Esophageal Squamous Cell Carcinoma Cell Lines  J Clin Med  2022  11(15):4426  PubMed ID: 35956043   DOI: 10.3390/jcm11154426

17703  Tanigawa K, Tsukamoto S, Koma YI, Kitamura Y, Urakami S, Shimizu M, Fujikawa M, Kodama T, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways  Am J Pathol  2022  192(3):536-552  PubMed ID: 34954212   DOI: 10.1016/j.ajpath.2021.12.002

20614  Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O.  Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.  Biochem Biophys Rep  2022  30:101246  PubMed ID: 35330672   DOI: 10.1016/j.bbrep.2022.101246

20714  Zhai Y, Shan C, Zhang H, Kong P, Zhang L, Wang Y, Hu X, Cheng X.  FAT1 downregulation enhances stemness and cisplatin resistance in esophageal squamous cell carcinoma.  Mol Cell Biochem  2022    PubMed ID: 35606602   DOI: 10.1007/s11010-022-04475-4

13383  Sakamoto H, Koma YI, Higashino N, Kodama T, Tanigawa K, Shimizu M, Fujikawa M, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages.  Lab Invest  2021  101(3):353-368  PubMed ID: 33311557   DOI: 10.1038/s41374-020-00512-2

20015  Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.  Am J Pathol  2021    PubMed ID: 33460563   DOI: 10.1016/j.ajpath.2021.01.004

20046  Mitsuda M, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33565032   DOI: 10.1245/s10434-021-09659-8

20071  Matsumoto Y, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.  Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma.  Ann Surg Oncol  2021    PubMed ID: 33710504   DOI: 10.1245/s10434-021-09752-y

16116  Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y.  APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation  Br J Cancer  2021  125(11):1523-1532  PubMed ID: 34599296   DOI: 10.1038/s41416-021-01561-0

13045  Kodama T, Koma YI, Arai N, Kido A, Urakawa N, Nishio M, Shigeoka M, Yokozaki H.  CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways.  Lab Invest  2020    PubMed ID: 32457351   DOI: 10.1038/s41374-020-0441-4

13092  Feng Y, Yan S, Huang Y, Huang Q, Wang F, Lei Y.  High expression of RABL6 promotes cell proliferation and predicts poor prognosis in esophageal squamous cell carcinoma.  BMC Cancer  2020    PubMed ID: 32600359   DOI: 10.1186/s12885-020-07068-w

13609  Okamoto M, Koma YI, Kodama T, Nishio M, Shigeoka M, Yokozaki H.  Growth Differentiation Factor 15 Promotes Progression of Esophageal Squamous Cell Carcinoma via TGF-β Type II Receptor Activation  Pathobiology  2020  87(2):100-113  PubMed ID: 31896114   DOI: 10.1159/000504394

11432  Kodaira H, Koma YI, Hosono M, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H.  ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma.  Pathol. Int.  2019    PubMed ID: 30758105   DOI: 10.1111/pin.12771

11583  Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH.  PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.  Cancer Lett.  2019    PubMed ID: 31173854   DOI: 10.1016/j.canlet.2019.05.040

11631  Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.  LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.  Am. J. Pathol.  2019    PubMed ID: 31323188   DOI: 10.1016/j.ajpath.2019.06.006

11699  Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer.  Cancer Sci  2019  110(6):1863-1871  PubMed ID: 31012515   DOI: 10.1111/cas.14028

12594  Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer  Cancer Sci  2019  110(12):3727-3737  PubMed ID: 31599475   DOI: 10.1111/cas.14214

10798  Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.  Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.  Oncogene  2018  37(26):3471-3484  PubMed ID: 29563607   DOI: 10.1038/s41388-018-0179-2

4355  Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.  Cancer Sci.  2018  109(2):412-421  PubMed ID: 29168598   DOI: 10.1111/cas.13454

4357  Kim MJ, Choi SK, Hong SH, Eun JW, Nam SW, Han JW, You JS.  Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal squamous cell carcinoma via modulation of acetylated FOXO1.  Int. J. Oncol.  2018  53(1):395-403  PubMed ID: 29749437   DOI: 10.3892/ijo.2018.4392

9448  Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii  p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4  Cancer Res  2018  78(21):6107-6120  PubMed ID: 30181180   DOI: 10.1158/0008-5472.CAN-18-1749

14899  Shiozaki A, Hikami S, Ichikawa D, Kosuga T, Shimizu H, Kudou M, Yamazato Y, Kobayashi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.  Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma  Oncotarget  2018  9(40):25993-26006  PubMed ID: 29899837   DOI: 10.18632/oncotarget.25417

10004  Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K.  Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development.  Int. J. Oncol.  2017  50:441-447  PubMed ID: 28035351   DOI: 10.3892/ijo.2016.3817

10141  Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.  Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.  Int. J. Cancer  2017  140:2608-2621  PubMed ID: 28233302   DOI: 10.1002/ijc.30666

10323  Liu K, Song G, Zhang X, Li Q, Zhao Y, Zhou Y, Xiong R, Hu X, Tang Z, Feng G.  PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma.  World J Surg Oncol  2017  15:105  PubMed ID: 28545451   DOI: 10.1186/s12957-017-1172-x

10353  Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.  Tumour Biol.  2017  39:1010428317700409  PubMed ID: 28618928   DOI: 10.1177/1010428317700409

10365  Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.  Oncol Lett  2017  14:1581-1587  PubMed ID: 28789382   DOI: 10.3892/ol.2017.6334

10692  Hosono M, Koma YI, Takase N, Urakawa N, Higashino N, Suemune K, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H.  CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells.  Oncotarget  2017  8:106071-106088  PubMed ID: 29285315   DOI: 10.18632/oncotarget.22526

14243  Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E.  Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma  Oncotarget  2017  8(11):17921-17935  PubMed ID: 28160546   DOI: 10.18632/oncotarget.14900

9656  Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y.  Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma.  Oncology  2016  90:347-55  PubMed ID: 27082627   DOI: 10.1159/000445323

9724  Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.  Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.  Br. J. Cancer  2016  115:66-75  PubMed ID: 27310703   DOI: 10.1038/bjc.2016.183

12638  Nakayama A, Aoki S, Uchihashi K, Nishijima-Matsunobu A, Yamamoto M, Kakihara N, Iwakiri R, Fujimoto K, Toda S.  Interaction between Esophageal Squamous Cell Carcinoma and Adipose Tissue in Vitro  Am J Pathol  2016  186(5):1180-94  PubMed ID: 26952643   DOI: 10.1016/j.ajpath.2016.01.003

12664  Shin WS, Hong Y, Lee HW, Lee ST.  Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells  Oncotarget  2016  7(45):73242-73256  PubMed ID: 27689325   DOI: 10.18632/oncotarget.12303

12903  Nishio M, Urakawa N, Shigeoka M, Takase N, Ichihara Y, Arai N, Koma Y, Yokozaki H.  Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma  Pathol Int  2016  66(2):83-93  PubMed ID: 26778807   DOI: 10.1111/pin.12381

12969  Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I.  Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma  Oncotarget  2016  7(13):17111-28  PubMed ID: 26958940   DOI: 10.18632/oncotarget.7937

13973  Takase N, Koma Y, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H.  NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells  Cancer Lett  2016  380(1):47-58  PubMed ID: 27317650   DOI: 10.1016/j.canlet.2016.06.009

13992  Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H.  UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma  Oncotarget  2016  7(36):57821-5783  PubMed ID: 27507047   DOI: 10.18632/oncotarget.11067

14108  Osako Y, Seki N, Kita Y, Yonemori K, Koshizuka K, Kurozumi A, Omoto I, Sasaki K, Uchikado Y, Kurahara H, Maemura K, Natsugoe S.  Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma  Int J Oncol  2016  49(6):2255-2264  PubMed ID: 27779648   DOI: 10.3892/ijo.2016.3745

14119  Park M, Yoon HJ, Kang MC, Kwon J, Lee HW.  PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma  Tumour Biol  2016  37(10):14217-14224  PubMed ID: 27557627   DOI: 10.1007/s13277-016-5288-3

7350  Nabeki B, Ishigami S, Uchikado Y, Sasaki K, Kita Y, Okumura H, Arigami T, Kijima Y, Kurahara H, Maemura K, Natsugoe S.  Interleukin-32 expression and Treg infiltration in esophageal squamous cell carcinoma.  Anticancer Res.  2015  35:2941-7  PubMed ID: 25964580

7382  Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.  The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.  BMC Cancer  2015  15:82  PubMed ID: 25884729   DOI: 10.1186/s12885-015-1065-8

7493  Wakita A, Motoyama S, Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y.  REG Iα activates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells.  Tumour Biol.  2015  36:5249-54  PubMed ID: 25656613   DOI: 10.1007/s13277-015-3183-y

15184  Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom  Anticancer Res  2015  35(9):4617-24  PubMed ID: 26254350

15226  Matsushita D, Uenosono Y, Arigami T, Yanagita S, Nishizono Y, Hagihara T, Hirata M, Haraguchi N, Arima H, Kijima Y, Kurahara H, Maemura K, Okumura H, Ishigami S, Natsugoe S.  Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma  Ann Surg Oncol  2015  22(11):3674-80  PubMed ID: 25652049   DOI: 10.1245/s10434-015-4392-8

15229  Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H.  Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma  Cancer Med  2015  4(3):437-46  PubMed ID: 25620088   DOI: 10.1002/cam4.401

15232  Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H.  GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways  Lab Invest  2015  95(5):491-503  PubMed ID: 25730371   DOI: 10.1038/labinvest.2015.36

13765  Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H.  Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer  Cancer Res  2014  74(2):575-85  PubMed ID: 24272485   DOI: 10.1158/0008-5472.CAN-13-1836

17149  Yeo SY, Ha SY, Yu EJ, Lee KW, Kim JH, Kim SH.  ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, pr  Oncotarget  2014  5(23):12260-72  PubMed ID: 25373738   DOI: 10.18632/oncotarget.2630

16294  Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M.  Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling  Proc Natl Acad Sci U S A  2013  110(11):E1026-34  PubMed ID: 23431153   DOI: 10.1073/pnas.1217072110

18742  Sugimura K, Miyata H, Tanaka K, Hamano R, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Mori M, Doki Y.  Let-7 expression is a significant determinant of response to chemotherapy through the regulation of IL-6/STAT3 pathway in esophageal squamous cell carcinoma  Clin Cancer Res  2012  18(18):5144-53  PubMed ID: 22847808   DOI: 10.1158/1078-0432.CCR-12-0701

8377  Usami S, Motoyama S, Koyota S, Wang J, Hayashi-Shibuya K, Maruyama K, Takahashi N, Saito H, Minamiya Y, Takasawa S, Ogawa J, Sugiyama T.  Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells.  Biochem. Biophys. Res. Commun.  2010  392:4-8  PubMed ID: 20056108   DOI: 10.1016/j.bbrc.2009.12.129

8430  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.  Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.  Int. J. Cancer  2010  127:543-54  PubMed ID: 19960436   DOI: 10.1002/ijc.25082

18707  Rahadiani N, Ikeda J, Makino T, Tian T, Qiu Y, Mamat S, Wang Y, Doki Y, Aozasa K, Morii E.  Tumorigenic role of podoplanin in esophageal squamous-cell carcinoma  Ann Surg Oncol  2010  17(5):1311-23  PubMed ID: 20066519   DOI: 10.1245/s10434-009-0895-5