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RCB1976 : Ca9-22  update : 2018/08/02
CommentHuman gingival carcinoma cell line. Expressing remarkable EGF receptor. HLA-A 2/24. TKG0485 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0485
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Tissue gingiva
Case history gingival carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0485)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 2
User's Publication 101


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Reference
3304  Kimura Y.  Studies on Lactate dehydrogenase isoenzymes in a cell line (Ca9-22) deribed from carcinoma of the gigiva  Kouku-byo Gakkai-shi  1978  45:20+35 
3306  orikoshi,M., Kimura,Y., Nagura,H., Ono,T., and Ito,H.  A new cell line derived from human carcinoma of the gingiva I. Its establishbint and morphological studies  Nihon Koku Geka Gakkai Zasshi  1974  20:100-106  PubMed ID: 4549822

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User's Publication
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
11377  Inoue K, Hatano K, Hanamatsu Y, Saigo C, Kito Y, Bunai K, Shibata T, Takeuchi T.  Pathobiological role of cleft palate transmembrane protein 1 family proteins in oral squamous cell carcinoma.  J. Cancer Res. Clin. Oncol.  2019    PubMed ID: 30635792
11497  Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.  Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells.  J. Biochem.  2019    PubMed ID: 30918974
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826
11566  Domon H, Hiyoshi T, Maekawa T, Yonezawa D, Tamura H, Kawabata S, Yanagihara K, Kimura O, Kunitomo E, Terao Y.  Antibacterial activity of hinokitiol against both antibiotic-resistant and -susceptible pathogenic bacteria that predominate in the oral cavity and upper airways.  Microbiol. Immunol.  2019    PubMed ID: 31106894
11584  Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW.  Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress.  Environ. Toxicol.  2019    PubMed ID: 31157515
11590  Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW.  Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells.  DNA Cell Biol.  2019    PubMed ID: 31170002
11620  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Anticancer Res.  2019    PubMed ID: 31262875
11761  Choi GE, Hyun KY.  Inhibitory effect of Acer tegmentosum maxim extracts on P. gingivalis LPS-induced periodontitis.  Arch. Oral Biol.  2019    PubMed ID: 31574324
11844  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Oral Dis  2019    PubMed ID: 31603606
11878  Watanabe N, Nodomi K, Koike R, Kato A, Takeichi O, Kotani AI, Kaneko T, Sakagami H, Takei M, Ogata Y, Sato S, Imai K.  EBV LMP1 in Gingival Epithelium Potentially Contributes to Human Chronic Periodontitis via Inducible IL8 Production.  In Vivo  2019    PubMed ID: 31662504
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705
10683  Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.  Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.  Biochem. Biophys. Res. Commun.  2018  495:2303-2309  PubMed ID: 29278708
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707
10727  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.  Anticancer Res.  2018  38:763-770  PubMed ID: 29374700
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10820  Fukamachi M, Kasamatsu A, Endo-Sakamoto Y, Fushimi K, Kasama H, Iyoda M, Minakawa Y, Shiiba M, Tanzawa H, Uzawa K.  Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer.  Exp. Cell Res.  2018  368:119-125  PubMed ID: 29679592
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549
11086  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675
11147  Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.  Anticancer Res.  2018  38(8):4449-4457  PubMed ID: 30061209
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493
4078  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Medicinal Chemistry Research  2018  27:2366–2378 
4172  Tamai R, Kobayashi-Sakamoto M, Kiyoura Y.  Extracellular galectin-1 enhances adhesion to and invasion of oral epithelial cells by Porphyromonas gingivalis.  Can. J. Microbiol.  2018    PubMed ID: 29544077
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845
4345  Hou B, Ishinaga H, Midorikawa K, Nakamura S, Hiraku Y, Oikawa S, Ma N, Takeuchi K, Murata M.  Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2.  Oncotarget  2018    PubMed ID: 29507664
9835  Evans M, Murofushi T, Tsuda H, Mikami Y, Zhao N, Ochiai K, Kurita-Ochiai T, Yamamoto M, Otsuka K, Suzuki N.  Combined effects of starvation and butyrate on autophagy-dependent gingival epithelial cell death.  J. Periodont. Res.  2017  52:522-531  PubMed ID: 27624546
9915  Tsubaki M, Fujiwara D, Takeda T, Kino T, Tomonari Y, Itoh T, Imano M, Satou T, Sakaguchi K, Nishida S.  The sensitivity of head and neck carcinoma cells to statins is related to the expression of their Ras expression status, and statin-induced apoptosis is mediated via suppression of the Ras/ERK and Ras/mTOR pathways.  Clin. Exp. Pharmacol. Physiol.  2017  44:222-234  PubMed ID: 27805296
9962  Nagano K, Hasegawa Y, Yoshida Y, Yoshimura F.  Comparative analysis of motility and other properties of Treponema denticola strains.  Microb. Pathog.  2017  102:82-88  PubMed ID: 27914958
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677
10344  Takada A, Matsushita K, Horioka S, Furuichi Y, Sumi Y.  Bactericidal effects of 310 nm ultraviolet light-emitting diode irradiation on oral bacteria.  BMC Oral Health  2017  17:96  PubMed ID: 28587675
10377  Takamura T, Suguro H, Mikami Y, Iwase T, Komiyama Y, Kuyama K, Komiyama K, Oki H.  Comparison of gene expression profiles of gingival carcinoma Ca9-22 cells and colorectal adenocarcinoma HT-29 cells to identify potentially important mediators of SLPI-induced cell migration.  J Oral Sci  2017  59:279-287  PubMed ID: 28637988
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404
10517  Murofushi T, Tsuda H, Mikami Y, Yamaguchi Y, Suzuki N.  CAY10591, a SIRT1 activator, suppresses cell growth, invasion, and migration in gingival epithelial carcinoma cells.  J Oral Sci  2017  59:415-423  PubMed ID: 28904318
10526  Ohno T, Yamamoto G, Hayashi JI, Nishida E, Goto H, Sasaki Y, Kikuchi T, Fukuda M, Hasegawa Y, Mogi M, Mitani A.  Angiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells.  PLoS ONE  2017  12:e0184825  PubMed ID: 28934245
10572  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797
10937    Effect of Micro/Nano-Patterned Surfaces on Cell Adhesion of Ca9-22 cells  e-J. Surf. Sci. Nanotech.  2017  15 : 1-6 
10958    Inactivation of dermatopontin via histone deacetylation in human oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29, 400-404 
4574  Yasui H, Ohnishi Y, Nakajima M, Nozaki M.  Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.  Oncol Rep  2017  37(6):3674-3680  PubMed ID: 28440510
6027  lNorihisa Ichimura et al  Notch3 is frequently downregulated in oral cancer  Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology   2017  29:504-510 
6641  Mariko Kawai, Kiyoshi Ohura  A Pilot Study of Antibody Drug Therapy to Regulate Cell Adhesion in Dental Implants  Open Journal of Stomatology  2017  7:494-500 
9558  Pal SK, Nguyen CT, Morita KI, Miki Y, Kayamori K, Yamaguchi A, Sakamoto K.  THBS1 is induced by TGFB1 in the cancer stroma and promotes invasion of oral squamous cell carcinoma.  J. Oral Pathol. Med.  2016  45:730-739  PubMed ID: 26850833
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818
9604  Chang HS, Tang JY, Yen CY, Huang HW, Wu CY, Chung YA, Wang HR, Chen IS, Huang MY, Chang HW.  Antiproliferation of Cryptocarya concinna-derived cryptocaryone against oral cancer cells involving apoptosis, oxidative stress, and DNA damage.  BMC Complement Altern Med  2016  16:94  PubMed ID: 26955958
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9702  Mikami Y, Fukushima A, Komiyama Y, Iwase T, Tsuda H, Higuchi Y, Hayakawa S, Kuyama K, Komiyama K.  Human uterus myoma and gene expression profiling: A novel in vitro model for studying secretory leukocyte protease inhibitor-mediated tumor invasion.  Cancer Lett.  2016  379:84-93  PubMed ID: 27238568
9762  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818
9783  Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K.  Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth.  PLoS ONE  2016  11:e0161163  PubMed ID: 27512993
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
7139  Sakaue Y, Domon H, Oda M, Takenaka S, Kubo M, Fukuyama Y, Okiji T, Terao Y.  Anti-biofilm and bactericidal effects of magnolia bark-derived magnolol and honokiol on Streptococcus mutans.  Microbiol. Immunol.  2015  60:10-6  PubMed ID: 26600203
7181  Gojoubori T, Ota H, Kusunoki M, Nishio Y, Nishio K, Iwasa S, Kaneko Y, Asano M.  Electrolytically generated acid functional water inhibits NF-κB activity by attenuating nuclear-cytoplasmic shuttling of p65 and p50 subunits.  J. Recept. Signal Transduct. Res.  2015  36:248-53  PubMed ID: 26480200
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864
6006  Ohnishi Y, Watanabe M, Yasui H, Kakudo K.  Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines.  Oncol Lett  2014  7(5):1439-1442  PubMed ID: 24765152
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069
5315  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790
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