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RCB1975 : HSC-3  update : 2018/08/02
CommentHuman tongue squamous cell carcinoma cell line. HLA-A 2/24. TKG0484 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Originator Momose, F.
Year of deposit 2004
Original cell TKG0484
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 64 years
Tissue tongue
Case history Squamous cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0484)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 3
User's Publication 121


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Reference
3303  Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.  Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S.  In Vitro Cell Dev Biol  1990  26:849-856  PubMed ID: 2228902
3248  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Ichijo H, Momose F, Miyazono K  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718
3243  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303

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User's Publication
7096  α-Glucosyl hesperidin suppressed the exacerbation of 5-fluorouracil-induced oral mucositis in the hamster cheek pouch.  Yoshino F, Yoshida A, Toyama T, Wada-T S, Takahashi S  J Functional Foods  2016  21:223-231 
7109  Telomerase activity in the occurrence and progression of oral squamous cell carcinoma.  Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K.  J Oral Sci  2015  57:295-303  PubMed ID: 26666852
7175  Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Int. J. Oncol.  2015  47:2165-72  PubMed ID: 26497980
7196  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690
7601  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286
7691  Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma.  Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H.  Cancer Sci.  2011  102:2164-71  PubMed ID: 21899661
7722  Comprehensive epigenetic analysis using oral rinse samples: a pilot study.  Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K.  J. Oral Maxillofac. Surg.  2011  70:1486-94  PubMed ID: 21821326
8085  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  In Vivo  2010  24:735-43  PubMed ID: 20952742
8383  Correlation between anti-survivin antibody and survivin mRNA expression in head and neck cancer patients.  Uemura N, Kodama S, Nomi N, Okamoto T, Suzuki M.  Acta Otolaryngol.  2010  130:959-65  PubMed ID: 20100132
9584  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  In Vivo  2016  30:91-7  PubMed ID: 26912818
9616  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9654  Rapid and Specific Screening Assay for KRAS Oncogene Mutation by a Novel Gene Amplification Method.  Kumasaka A, Matsumoto N, Mukae S, Kitano T, Noguchi H, Ohki H, Komiyama K, Ando T.  Anticancer Res.  2016  36:1571-9  PubMed ID: 27069133
9676  Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.  Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A.  Anticancer Res.  2016  36:2161-8  PubMed ID: 27127118
9694  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Harada K, Ferdous T, Harada T, Ueyama Y.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058
9762  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818
9808  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  In Vivo  2016  30:645-50  PubMed ID: 27566085
9851  Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis.  Masui A, Hamada M, Kameyama H, Wakabayashi K, Takasu A, Imai T, Iwai S, Yura Y.  PLoS ONE  2016  11:e0162786  PubMed ID: 27658240
9892  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902
9896  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918
9911  Antiviral and Antitumor Activity of Licorice Root Extracts.  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2016  30:777-785  PubMed ID: 27815461
10044  Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.  Ohkoshi E, Umemura N.  Int. J. Oncol.  2017  50:387-395  PubMed ID: 28035370
10148  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10191  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10197  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260
10201  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269
10206  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Molecules  2017  22:  PubMed ID: 28294988
10241  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677
10386  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  In Vivo  2017  31:591-598  PubMed ID: 28652425
10576  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797
10649  Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma.  Koshizuka K, Hanazawa T, Kikkawa N, Katada K, Okato A, Arai T, Idichi T, Osako Y, Okamoto Y, Seki N.  Auris Nasus Larynx  2018  45:854-865  PubMed ID: 29233721
10664  Molecularly-targeted therapy for the oral cancer stem cells.  Ohnishi Y, Yasui H, Nozaki M, Nakajima M.  Jpn Dent Sci Rev  2018  54:88-103  PubMed ID: 29755619
10668  Toll-like receptor 2 activation implicated in oral squamous cell carcinoma development.  Ikehata N, Takanashi M, Satomi T, Watanabe M, Hasegawa O, Kono M, Enomoto A, Chikazu D, Kuroda M.  Biochem. Biophys. Res. Commun.  2018  495:2227-2234  PubMed ID: 29269299
10691  Three-dimensional cultured tissue constructs that imitate human living tissue organization for analysis of tumor cell invasion.  Iwai S, Kishimoto S, Amano Y, Nishiguchi A, Matsusaki M, Takeshita A, Akashi M.  J Biomed Mater Res A  2019  107(2):292-300  PubMed ID: 29280265
10724  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707
10806  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10829  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2018  32:479-486  PubMed ID: 29695549
11036  Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation    Int J Cancer Oncol  2017  4: 225- 230 
11110  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454
11115  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510
11148  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210
11226  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2018    PubMed ID: 30271493
11300  Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma.  Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.  Int. J. Oncol.  2019    PubMed ID: 30431077
11306  Suramin, screened from an approved drug library, inhibits HuR functions and attenuates malignant phenotype of oral cancer cells.  Kakuguchi W, Nomura T, Kitamura T, Otsuguro S, Matsushita K, Sakaitani M, Maenaka K, Tei K.  Cancer Med  2018    PubMed ID: 30449075
11350  DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways.  Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Fujita S.  Int. J. Oncol.  2019    PubMed ID: 30569110
11354  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
4173  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vivo  2018    PubMed ID: 29695558
4235  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Oncotarget  2018    PubMed ID: 30333913
4236  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Oncol. Rep.  2018    PubMed ID: 29192320
4237  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Mol Clin Oncol  2018    PubMed ID: 29456845
4238  The luminance ratio of autofluorescence in a xenograft mouse model is stable through tumor growth stages.  Sumi S, Umemura N, Adachi M, Ohta T, Naganawa K, Kawaki H, Takayama E, Kondoh N, Sumitomo S.  Clin Exp Dent Res  2018    PubMed ID: 30386639
4239  Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma.  Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D.  Int. J. Oncol.  2018    PubMed ID: 29344674
4240  DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.  Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M.  Arch. Oral Biol.  2018    PubMed ID: 29522917
4241  Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.  Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI.  Oncol. Rep.  2018    PubMed ID: 30132562
4242  Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.  Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.  Int. J. Oncol.  2018    PubMed ID: 29115586
5422  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695
5611  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  Wakabayashi H, Narita T, Suga A, Sakagami H.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973
6020  Red LED Light Is Influenced by IL-6 to Promote the Migration Ability of Oral Squamous Cell Carcinoma Cell Line.  Matsuo K, Suzuki H, Yatagai N, Enomoto Y, Kitayama M, Shigeoka M, Kimoto A, Matsumoto K, Komori T.  Kobe J Med Sci  2019  64(6):E210-E216  PubMed ID: 31327864
6024  Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells.  Hamada M, Kameyama H, Iwai S, Yura Y.  Cell Death Discov  2017  3:17047  PubMed ID: 29109864
6032  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Tada H, Shimizu T, Nagaoka I, Takada H.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607
6033  Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.  Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R.  Int J Oncol  2016  48(4):1670-8  PubMed ID: 26893131
6036  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
6042  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332
6043  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471
6044  Adenosine A2b receptor promotes progression of human oral cancer.  Kasama H et al   BMC Cancer  2015  15:563  PubMed ID: 26228921
6051  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  Okamoto A et al  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377
6052  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  Saito T et al  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Miyamoto I et al  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
6058  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  Shida-Sakazume T et al  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864
6023  NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma.  Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M.  Oncol Lett  2014  7(1):35-40  PubMed ID: 24348816
6006  Effects of epidermal growth factor on the invasive activity and cytoskeleton of oral squamous cell carcinoma cell lines.  Ohnishi Y, Watanabe M, Yasui H, Kakudo K.  Oncol Lett  2014  7(5):1439-1442  PubMed ID: 24765152
5916  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  In Vivo  2014  28(4):549-56  PubMed ID: 24982221
5859  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344
5807  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906
5778  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469
5659  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035
5605  Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.  Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.  PLoS One  2014  9(12):e114121  PubMed ID: 25437003
5544  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367
5337  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069
5315  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705
5307  Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  J Transl Med  2014  12:265  PubMed ID: 25240937
5122  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  Iida S, Shimada J, Sakagami H.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687
5110  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061
5057  Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.  Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y.  Int J Cancer.  2013  132(12):2755-66  PubMed ID: 23180648
6070  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790
6071  Hypoxia-induced reactive oxygen species cause chromosomal abnormalities in endothelial cells in the tumor microenvironment.  Kondoh M, Ohga N, Akiyama K, Hida Y, Maishi N, Towfik AM, Inoue N, Shindoh M, Hida K.  PLoS One  2013  8(11):e80349  PubMed ID: 4260373
6072  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564
6076  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490
6077  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247
6078  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548
6081  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  BMC Cancer  2013  13:555  PubMed ID: 24261884
6083  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 4045666
6087  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889
6088  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311
6089  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  J Oral Sci  2012  54(3):241-50  PubMed ID: 2304703
6095  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894
6098  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Tumour Biol  2012  33(1):183-94  PubMed ID: 2081310
6109  A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.  Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M.  Int J Oncol  2011  39(6):1401-5  PubMed ID: 21785818
6112  Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines  lHiroshi Inoue et al  Asian Journal of Oral and Maxillofacial Surgery   2011  23:1-6 
6116  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983
6118  Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer  Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo  Journal of Osaka Dental University  2011  45:31-36 
6120  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673
6122  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Nomi N, Kodama S, Suzuki M.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466
6123  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  Yuji Miyazaki et al  J Cancer Sci Ther  2010  2(2) :26-32 
6127  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319
6128  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186
6129  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354
6136  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Okamura M, Shimada J, Sakagami H.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853
6138  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res  2008  28(2A):1069-78 
6140  Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.  Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T.  In Vivo  2008  2(4):471-6  PubMed ID: 18712174
6141  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558
6143  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225
6148  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125
6150  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456
6152  Cytotoxic activity of azulenequinones against human oral tumor cell lines.  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H.  Anticancer Res  2005  25(1A):305-12  PubMed ID: 15816552
11584  Ethyl acetate extract of Nepenthes adrianii x clipeata induces antiproliferation, apoptosis, and DNA damage against oral cancer cells through oxidative stress.  Tang JY, Peng SY, Cheng YB, Wang CL, Farooqi AA, Yu TJ, Hou MF, Wang SC, Yen CH, Chan LP, Ou-Yang F, Chang HW.  Environ. Toxicol.  2019    PubMed ID: 31157515
11590  Ethyl Acetate Extract of Nepenthes ventricosa x maxima Exerts Preferential Killing to Oral Cancer Cells.  Tang JY, Li LJ, Ou-Yang F, Wang CL, Shu CW, Wu KH, Wang HR, Yen CH, Cheng YB, Chang HW.  DNA Cell Biol.  2019    PubMed ID: 31170002
11620  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Anticancer Res.  2019    PubMed ID: 31262875
11759  Resveratrol Targets Urokinase-Type Plasminogen Activator Receptor Expression to Overcome Cetuximab-Resistance in Oral Squamous Cell Carcinoma.  Uzawa K, Amelio AL, Kasamatsu A, Saito T, Kita A, Fukamachi M, Sawai Y, Toeda Y, Eizuka K, Hayashi F, Kato-Kase I, Sunohara M, Iyoda M, Koike K, Nakashima D, Ogawara K, Endo-Sakamoto Y, Shiiba M, Takiguchi Y, Yamauchi M, Tanzawa H.  Sci Rep  2019    PubMed ID: 31434965
11844  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  Oral Dis  2019    PubMed ID: 31603606
6410  Is parainfluenza virus a threatening virus for human cancer cell lines?  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309



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