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Cell No. : Cell Name
RCB1960 : HuCCT1  update : 2023/11/27
CommentHuman bile duct carcinoma. This cell line produces carbohydrate antigen 19/9 in serum-free medium. TKG0389 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Miyagiwa, M. (Okayama Univ.)
Year of deposit 2004
Original cell TKG0389
Animal _human < Mammals
Genus Homo
Species sapiens
Age at sampling 56 years
Tissue bile duct, ascites meta
Disease name bile duct carcinoma.
Metastatic ability Yes
Metastatic tissue asites
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0389)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0324
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Virus (HBV) (-)
Virus (HCV) (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 103


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Reference
5058  Matsuzaki K, Yoshitake Y, Miyagiwa M, Minemura M, Tanaka M, Sasaki H, Nishikawa K.  Production of basic fibroblast growth factor-like factor by cultured human cholangiocellular carcinoma cells.  Jpn J Cancer Res  1990  81(4):345-54  PubMed ID: 2163997   DOI: 10.1111/j.1349-7006.1990.tb02574.x
3279  Miyagiwa M, Ichida T, Tokiwa T, Sato J, Sasaki H  A new human cholangiocellular carcinoma cell line (HuCC-T1) producing carbohydrate antigen 19/9 in serum-free medium  In Vitro Cell Dev Biol Anim  1989  25:503-510  PubMed ID: 2544546   DOI: 10.1007/BF02623562

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User's Publication
20994  Deshmukh D, Hsu YF, Chiu CC, Jadhao M, Hsu SCN, Hu SY, Yang SH, Liu W.  Antiangiogenic potential of Lepista nuda extract suppressing MAPK/p38 signaling-mediated developmental angiogenesis in zebrafish and HUVECs.  Biomed Pharmacother  2023  159:114219  PubMed ID: 36621144   DOI: 10.1016/j.biopha.2023.114219
21103  Shi L, Shen W, Davis MI, Kong K, Vu P, Saha SK, Adil R, Kreuzer J, Egan R, Lee TD, Greninger P, Shrimp JH, Zhao W, Wei TY, Zhou M, Eccleston J, Sussman J, Manocha U, Weerasekara V, Kondo H, Vijay V, Wu MJ, Kearney SE, Ho J, McClanaghan J, Murchie E, Crowther GS, Patnaik S, Boxer MB, Shen M, Ting DT, Kim WY, Stanger BZ, Deshpande V, Ferrone CR, Benes CH, Haas W, Hall MD, Bardeesy N.  SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.  Nat Cancer  2023    PubMed ID: 36914816   DOI: 10.1038/s43018-023-00523-0
21456  Toshida K, Itoh S, Iseda N, Izumi T, Yoshiya S, Toshima T, Ninomiya M, Iwasaki T, Oda Y, Yoshizumi T.  Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma.  Cancer Sci  2023    PubMed ID: 37878531   DOI: 10.1111/cas.15981
21553  Louis C, Ferlier T, Leroux R, Pineau R, Desoteux M, Papoutsoglou P, Leclerc D, Angenard G, Vaquero J, Macias RIR, Edeline J, Coulouarn C.  TGFβ-induced circLTBP2 predicts a poor prognosis in intrahepatic cholangiocarcinoma and mediates gemcitabine resistance by sponging miR-338-3p.  JHEP Rep  2023  5(12):100900  PubMed ID: 38023605   DOI: 10.1016/j.jhepr.2023.100900
17559  Wu WS, Ling CH, Lee MC, Cheng CC, Chen RF, Lin CF, You RI, Chen YC.  Targeting Src-Hic-5 Signal Cascade for Preventing Migration of Cholangiocarcinoma Cell HuCCT  Biomedicines  2022  10(5):1022  PubMed ID: 35625759   DOI: 10.3390/biomedicines10051022
17715  Zhang L, Ma D, Li F, Qiu G, Sun D, Zeng Z.  Lnc-PKD2-2-3/miR-328/GPAM ceRNA Network Induces Cholangiocarcinoma Proliferation, Invasion and 5-FU Chemoresistance  Front Oncol  2022  12:871281  PubMed ID: 35965521   DOI: 10.3389/fonc.2022.871281
18223  Mancarella S, Serino G, Gigante I, Cigliano A, Ribback S, Sanese P, Grossi V, Simone C, Armentano R, Evert M, Calvisi DF, Giannelli G.  CD90 is regulated by notch1 and hallmarks a more aggressive intrahepatic cholangiocarcinoma phenotype  J Exp Clin Cancer Res  2022  41(1):65  PubMed ID: 35172861   DOI: 10.1186/s13046-022-02283-8
18224  Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S.  Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53  Chem Res Toxicol  2022  35(9):1598-1603  PubMed ID: 36027604   DOI: 10.1021/acs.chemrestox.2c00202
16108  Mohamed FEZ, Jalan R, Minogue S, Andreola F, Habtesion A, Hall A, Winstanley A, Damink SO, Malagó M, Davies N, Luong TV, Dhillon A, Mookerjee R, Dhar D, Al-Jehani RM.  Inhibition of TLR7 and TLR9 Reduces Human Cholangiocarcinoma Cell Proliferation and Tumor Development  Dig Dis Sci  2022  67(5):1806-1821  PubMed ID: 33939146   DOI: 10.1007/s10620-021-06973-9
16279  Seo HR, Nam AR, Bang JH, Oh KS, Kim JM, Yoon J, Kim TY, Oh DY.  Inhibition of WEE1 Potentiates Sensitivity to PARP Inhibitor in Biliary Tract Cancer  Cancer Res Treat  2022  Aug 6  PubMed ID: 34352995   DOI: 10.4143/crt.2021.473
20601  Tessiri S, Techasen A, Kongpetch S, Namjan A, Loilome W, Chan-On W, Thanan R, Jusakul A.  Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma.  PeerJ  2022  10:e12750  PubMed ID: 35070505   DOI: 10.7717/peerj.12750
20634  Yamamoto Y, Sugimoto A, Maruo K, Tsujio G, Sera T, Kushiyama S, Nishimura S, Kuroda K, Togano S, Eguchi S, Tanaka R, Kimura K, Amano R, Ohira M, Yashiro M.  CXCR2 signaling might have a tumor-suppressive role in patients with cholangiocarcinoma.  PLoS One  2022  17(4):e0266027  PubMed ID: 35377900   DOI: 10.1371/journal.pone.0266027
16513  Gundlach JP, Kerber J, Hendricks A, Bernsmeier A, Halske C, Röder C, Becker T, Röcken C, Braun F, Sebens S, Heits N.  Paracrine Interaction of Cholangiocellular Carcinoma with Cancer-Associated Fibroblasts and Schwann Cells Impact Cell Migration  J Clin Med  2022  11(10):2785  PubMed ID: 35628911   DOI: 10.3390/jcm11102785
20763  Tanaka R, Kimura K, Eguchi S, Ohira G, Tanaka S, Amano R, Tanaka H, Yashiro M, Ohira M, Kubo S.  Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line.  BMC Cancer  2022  22(1):748  PubMed ID: 35804329   DOI: 10.1186/s12885-022-09847-z
20772  Tanaka M, Kunita A, Yamagishi M, Katoh H, Ishikawa S, Yamamoto H, Abe J, Arita J, Hasegawa K, Shibata T, Ushiku T.  KRAS mutation in intrahepatic cholangiocarcinoma: linkage with metastasis-free survival and reduced E-cadherin expression.  Liver Int  2022    PubMed ID: 35833881   DOI: 10.1111/liv.15366
20794  Chen S, Nishi M, Morine Y, Yoshikawa K, Tokunaga T, Kashihara H, Takasu C, Wada Y, Yoshimoto T, Nakamoto A, Sakai T, Shimada M.  Polymethoxylated flavone sudachitin is a safe anticancer adjuvant that targets glycolysis in cancer-associated fibroblasts.  Oncol Lett  2022  24(1):236  PubMed ID: 35720469   DOI: 10.3892/ol.2022.13356
20986  Rattanasinchai C, Navasumrit P, Ruchirawat M.  Elevated ITGA2 expression promotes collagen type I-induced clonogenic growth of intrahepatic cholangiocarcinoma.  Sci Rep  2022  12(1):22429  PubMed ID: 36575207   DOI: 10.1038/s41598-022-26747-1
21003  Leelawat S, Leelawat K, Yimsoo T, Wunnakup T, Monton C, Khamthong N, Madaka F, Maha A, Songsak T.  Antitumor Effects of Delta (9)-Tetrahydrocannabinol and Cannabinol on Cholangiocarcinoma Cells and Xenograft Mouse Models.  Evid Based Complement Alternat Med  2022  6477132  PubMed ID: 36452140   DOI: 10.1155/2022/6477132
21043  Wu WS, Chen RF, Cheng CC, Wei JL, Lin CF, You RI, Chen YC, Lee MC, Chen YC.  Suppressing of Src-Hic-5-JNK-AKT Signaling Reduced GAPDH Expression for Preventing the Progression of HuCCT1 Cholangiocarcinoma.  Pharmaceutics  2022  14(12)  PubMed ID: 36559193   DOI: 10.3390/pharmaceutics14122698
13410  Saijoh S, Nakamura-Shima M, Shibuya-Takahashi R, Ito R, Sugawara A, Yamazaki T, Imai T, Asada Y, Matsuura K, Iwai W, Wakui Y, Abue M, Kawamura S, Katayose Y, Fujimori H, Mochizuki M, Yasuda J, Yamaguchi K, Sugamura K, Satoh K, Katori Y, Tamai K.  Discovery of a chemical compound that suppresses expression of BEX2, a dormant cancer stem cell-related protein.  Biochem Biophys Res Commun  2021    PubMed ID: 33412384   DOI: 10.1016/j.bbrc.2020.11.022
13485  Hirata H, Kuwatani M, Nakajima K, Kodama Y, Yoshikawa Y, Ogawa M, Sakamoto N.  Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes  Cancer Sci  2021  112(2):828-838  PubMed ID: 33345417   DOI: 10.1111/cas.14780
20017  Rose S, Ezan F, Cuvellier M, Bruyère A, Legagneux V, Langouët S, Baffet G.  Generation of proliferating human adult hepatocytes using optimized 3D culture conditions.  Sci Rep  2021  11(1):515  PubMed ID: 33436872   DOI: 10.1038/s41598-020-80019-4
13539  Nagaoka K, Ogawa K, Ji C, Cao KY, Bai X, Mulla J, Cheng Z, Wands JR, Huang CK.  Targeting Aspartate Beta-Hydroxylase with the Small Molecule Inhibitor MO-I-1182 Suppresses Cholangiocarcinoma Metastasis  Dig Dis Sci  2021  66(4):1080-1089  PubMed ID: 32445050   DOI: 10.1007/s10620-020-06330-2
20163  Nam AR, Yoon J, Jin MH, Bang JH, Oh KS, Seo HR, Kim JM, Kim TY, Oh DY.  ATR inhibition amplifies antitumor effects of olaparib in biliary tract cancer.  Cancer Lett  2021  516:38-47  PubMed ID: 34082024   DOI: 10.1016/j.canlet.2021.05.029
20178  Cen W, Li J, Tong C, Zhang W, Zhao Y, Lu B, Yu J.  Intrahepatic Cholangiocarcinoma Cells Promote Epithelial-mesenchymal Transition of Hepatocellular Carcinoma Cells by Secreting LAMC2.  J Cancer  2021  12(12):3448-3457  PubMed ID: 33995623   DOI: 10.7150/jca.55627
20228  Gamma-synuclein is a novel prognostic marker that promotes tumor cell migration in biliary tract carcinoma.  Takemura Y, Ojima H, Oshima G, Shinoda M, Hasegawa Y, Kitago M, Yagi H, Abe Y, Hori S, Fujii-Nishimura Y, Kubota N, Masuda Y, Hibi T, Sakamoto M, Kitagawa Y.  Cancer Med  2021    PubMed ID: 34245137   DOI: 10.1002/cam4.4121
15516  Hozaka Y, Seki N, Tanaka T, Asai S, Moriya S, Idichi T, Wada M, Tanoue K, Kawasaki Y, Mataki Y, Kurahara H, Ohtsuka T.  Molecular Pathogenesis and Regulation of the miR-29-3p-Family: Involvement of ITGA6 and ITGB1 in Intra-Hepatic Cholangiocarcinoma  ancers (Basel)   2021  13(11):2804  PubMed ID: 34199886   DOI: 10.3390/cancers13112804
16106  Wang D, Xiong F, Wu G, Liu W, Wang B, Chen Y.  MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway  Cancer Cell Int  2021  ;21(1):656  PubMed ID: 34876142   DOI: 10.1186/s12935-021-02374-0
16761  Bai X, Zhang H, Zhou Y, Nagaoka K, Meng J, Ji C, Liu D, Dong X, Cao K, Mulla J, Cheng Z, Mueller W, Bay A, Hildebrand G, Lu S, Wallace J, Wands JR, Sun B, Huang CK.  Ten-Eleven Translocation 1 Promotes Malignant Progression of Cholangiocarcinoma With Wild-Type Isocitrate Dehydrogenase 1  Hepatology  2021  73(5):1747-1763  PubMed ID: 32740973   DOI: 10.1002/hep.31486
12007  Win Maung HM, Chan-On W, Kunkeaw N, Khaenam P.  Common transcriptional programs and the role of chemokine (C-C motif) ligand 20 (CCL20) in cell migration of cholangiocarcinoma.  EXCLI J  2020    PubMed ID: 32194362   DOI: 10.17179/excli2019-1893
12036  San TT, Khaenam P, Prachayasittikul V, Sripa B, Kunkeaw N, Chan-On W.  Curcumin enhances chemotherapeutic effects and suppresses ANGPTL4 in anoikis-resistant cholangiocarcinoma cells.  Heliyon  2020    PubMed ID: 32051864   DOI: 10.1016/j.heliyon.2020.e03255
12044  Fukuda Y, Asaoka T, Eguchi H, Yokota Y, Kubo M, Kinoshita M, Urakawa S, Iwagami Y, Tomimaru Y, Akita H, Noda T, Gotoh K, Kobayashi S, Hirata M, Wada H, Mori M, Doki Y.  Endogenous CXCL9 affects prognosis by regulating tumor-infiltrating natural killer cells in intrahepatic cholangiocarcinoma.  Cancer Sci.  2020    PubMed ID: 31799781   DOI: 10.1111/cas.14267
12462  Yoshino J, Akiyama Y, Shimada S, Ogura T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Yamaoka S, Tanabe M, Tanaka S.  Loss of ARID1A induces a stemness gene ALDH1A1 expression with histone acetylation in the malignant subtype of cholangiocarcinoma  Carcinogenesis  2020  41(6):734-742  PubMed ID: 31665232   DOI: 10.1093/carcin/bgz179
12987  Wang Y, Wild AT, Turcan S, Wu WH, Sigel C, Klimstra DS, Ma X, Gong Y, Holland EC, Huse JT, Chan TA.  Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas.  Sci Adv  2020    PubMed ID: 32494639   DOI: 10.1126/sciadv.aaz3221
13005  Hsieh CH, Chu CY, Lin SE, Yang YSH, Chang HS, Yen Y.  TESC Promotes TGF-α/EGFR-FOXM1-Mediated Tumor Progression in Cholangiocarcinoma.  Cancers (Basel)  2020    PubMed ID: 32365487   DOI: 10.3390/cancers12051105
13336  Pan YR, Wu CE, Yeh CN.  ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner.  Biomolecules  2020    PubMed ID: 33182492   DOI: 10.3390/biom10111529
13552  Nam AR, Jin MH, Bang JH, Oh KS, Seo HR, Oh DY, Bang YJ.  Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer  Cancer Res Treat  2020  52(3):945-956  PubMed ID: 32311864   DOI: 10.4143/crt.2020.080
13897  Liu F, Zhu C, Gao P, Zheng S, Li C.  Ubiquitin-conjugating enzyme E2T regulates cell proliferation and migration in cholangiocarcinoma  Anticancer Drugs  2020  31(8):836-846  PubMed ID: 32796405   DOI: 10.1097/CAD.0000000000000955
13917  Tamai K, Nakamura-Shima M, Shibuya-Takahashi R, Kanno SI, Yasui A, Mochizuki M, Iwai W, Wakui Y, Abue M, Yamamoto K, Miura K, Mizuma M, Unno M, Kawamura S, Sato I, Yasuda J, Yamaguchi K,   BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma  Sci Rep  2020  10(1):21592  PubMed ID: 33299012   DOI: 10.1038/s41598-020-78539-0
16133  Fu W, Yu G, Liang J, Fan P, Dong K, Zhang B, Chen X, Zhu H, Chu L.  miR-144-5p and miR-451a Inhibit the Growth of Cholangiocarcinoma Cells Through Decreasing the Expression of ST8SIA4  Front Oncol  2020  10:563486  PubMed ID: 33520692   DOI: 10.3389/fonc.2020.563486
11443  Brun S, Bassissi F, Serdjebi C, Novello M, Tracz J, Autelitano F, Guillemot M, Fabre P, Courcambeck J, Ansaldi C, Raymond E, Halfon P.  GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma.  Invest New Drugs  2019    PubMed ID: 30778887   DOI: 10.1007/s10637-019-00741-3
11459  Farley AM, Braxton DR, Li J, Trounson K, Sakar-Dey S, Nayer B, Ikeda T, Lau KX, Hardikar W, Hasegawa K, Pera MF.  Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma.  Sci Rep  2019    PubMed ID: 30814526   DOI: 10.1038/s41598-019-38988-8
11476  Wei K, Li M, Zöller M, Wang M, Mehrabi A, Hoffmann K.  Targeting c-MET by Tivantinib through synergistic activation of JNK/c-jun pathway in cholangiocarcinoma.  Cell Death Dis  2019    PubMed ID: 30850583   DOI: 10.1038/s41419-019-1460-1
4244  Nam AR, Jin MH, Park JE, Bang JH, Oh DY, Bang YJ.  Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.  Cancer Res Treat  2019  51(3):1167-1179  PubMed ID: 30514066   DOI: 10.4143/crt.2018.526
4245  Nam AR, Kim JW, Park JE, Bang JH, Jin MH, Oh DY, Bang YJ.  Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer.  Cancer Res Treat  2019  51(3):886-900  PubMed ID: 30282449   DOI: 10.4143/crt.2018.375
3737  Sakamoto Y, Yamagishi S, Okusaka T, Ojima H.  Synergistic and Pharmacotherapeutic Effects of Gemcitabine and Cisplatin Combined Administration on Biliary Tract Cancer Cell Lines.  Cells  2019  8(9):1026  PubMed ID: 31484399   DOI: 10.3390/cells8091026
14816  Goyal L, Shi L, Liu LY, Fece de la Cruz F, Lennerz JK, Raghavan S, Leschiner I, Elagina L, Siravegna G, Ng RWS, Vu P, Patra KC, Saha SK, Uppot RN, Arellano R, Reyes S, Sagara T, Otsuki S, Nadres B, Shahzade HA, Dey-Guha I, Fetter IJ, Baiev I, Van Seventer EE, Murphy JE, Ferrone CR, Tanabe KK, Deshpande V, Harding JJ, Yaeger R, Kelley RK, Bardelli A, Iafrate AJ, Hahn WC, Benes CH, Ting DT, Hirai H, Getz G, Juric D, Zhu AX, Corcoran RB, Bardeesy N.  TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma  Cancer Discov  2019  9(8):1064-1079  PubMed ID: 31109923   DOI: 10.1158/2159-8290.CD-19-0182
10684  Kawashita Y, Morine Y, Saito Y, Takasu C, Ikemoto T, Iwahashi S, Teraoku H, Yoshikawa M, Imura S, Yagi T, Shimada M.  Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas.  J. Gastroenterol. Hepatol.  2018  33(7):1407-1412  PubMed ID: 29278438   DOI: 10.1111/jgh.14078
10740  Merdrignac A, Angenard G, Allain C, Petitjean K, Bergeat D, Bellaud P, Fautrel A, Turlin B, Clément B, Dooley S, Sulpice L, Boudjema K, Coulouarn C.  A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma.  Hepatol Commun  2018  2:254-269  PubMed ID: 29507901   DOI: 10.1002/hep4.1142
10759  Sakamoto Y, Yamagishi S, Tanizawa Y, Tajimi M, Okusaka T, Ojima H.  PI3K-mTOR pathway identified as a potential therapeutic target in biliary tract cancer using a newly established patient-derived cell panel assay.  Jpn. J. Clin. Oncol.  2018  48:396-399  PubMed ID: 29474549   DOI: 10.1093/jjco/hyy011
11330  Komatsu N, Kajiya M, Motoike S, Takewaki M, Horikoshi S, Iwata T, Ouhara K, Takeda K, Matsuda S, Fujita T, Kurihara H.  Type I collagen deposition via osteoinduction ameliorates YAP/TAZ activity in 3D floating culture clumps of mesenchymal stem cell/extracellular matrix complexes.  Stem Cell Res Ther  2018    PubMed ID: 30526677   DOI: 10.1186/s13287-018-1085-9
11345  Kim J, Kim H, Lee JC, Kim JW, Paik WH, Lee SH, Hwang JH, Ryu JK, Kim YT.  Human equilibrative nucleoside transporter 1 (hENT1) expression as a predictive biomarker for gemcitabine chemotherapy in biliary tract cancer.  PLoS ONE  2018    PubMed ID: 30557411   DOI: 10.1371/journal.pone.0209104
4339  Mori A, Masuda K, Ohtsuka H, Shijo M, Ariake K, Fukase K, Sakata N, Mizuma M, Morikawa T, Hayashi H, Nakagawa K, Motoi F, Naitoh T, Fujishima F, Unno M.  FBXW7 modulates malignant potential and cisplatin-induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1.  Cancer Sci.  2018    PubMed ID: 30302867   DOI: 10.1111/cas.13829
4347  Lin HY, Tey SL, Ho Y, Chin YT, Wang K, Whang-Peng J, Shih YJ, Chen YR, Yang YN, Chen YC, Liu YC, Tang HY, Yang YS.  Heteronemin Induces Anti-Proliferation in Cholangiocarcinoma Cells via Inhibiting TGF-β Pathway.  Mar Drugs  2018    PubMed ID: 30563284   DOI: 10.3390/md16120489
4486  Nepal C, O'Rourke CJ, Oliveira DVNP, Taranta A, Shema S, Gautam P, Calderaro J, Barbour A, Raggi C, Wennerberg K, Wang XW, Lautem A, Roberts LR, Andersen JB.  Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma.  Hepatology  2018  68(3):949-963  PubMed ID: 29278425   DOI: 10.1002/hep.29764
14301  Wang J, Zhang ZG, Ding ZY, Dong W, Liang HF, Chu L, Zhang BX, Chen XP.  IDH1 mutation correlates with a beneficial prognosis and suppresses tumor growth in IHCC  J Surg Res  2018  231:116-125  PubMed ID: 30278918   DOI: 10.1016/j.jss.2018.04.056
14913  Lin G, Lin KJ, Wang F, Chen TC, Yen TC, Yeh TS.  Synergistic antiproliferative effects of an mTOR inhibitor (rad001) plus gemcitabine on cholangiocarcinoma by decreasing choline kinase activity  Dis Model Mech  2018  11(8):dmm03305  PubMed ID: 29666220   DOI: 10.1242/dmm.033050
10290  Quintavalle C, Burmeister K, Piscuoglio S, Quagliata L, Karamitopoulou E, Sepe R, Fusco A, Terracciano LM, Andersen JB, Pallante P, Matter MS.  High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy.  Mol. Carcinog.  2017  56:2146-2157  PubMed ID: 28467612   DOI: 10.1002/mc.22671
10312  Račkauskas R, Zhou D, Ūselis S, Strupas K, Herr I, Schemmer P.  Sulforaphane sensitizes human cholangiocarcinoma to cisplatin via the downregulation of anti-apoptotic proteins.  Oncol. Rep.  2017  37:3660-3666  PubMed ID: 28498473   DOI: 10.3892/or.2017.5622
10363  Li P, Zhang L, Yang M, Qi M, Jin X, Han B.  Cul4B is a novel prognostic marker in cholangiocarcinoma.  Oncol Lett  2017  14:1265-1274  PubMed ID: 28808481   DOI: 10.3892/ol.2017.6297
10461  Nooron N, Ohba K, Takeda K, Shibahara S, Chiabchalard A.  Dysregulated Expression of MITF in Subsets of Hepatocellular Carcinoma and Cholangiocarcinoma.  Tohoku J. Exp. Med.  2017  242:291-302  PubMed ID: 28794318   DOI: 10.1620/tjem.242.291
5430  Li C, Imai M, Yamasaki M, Hasegawa S, Takahashi N.  Effects of Pre- and Post-Administration of Vitamin A on the Growth of Refractory Cancers in Xenograft Mice.  Biol Pharm Bull  2017  40(4):486-494  PubMed ID: 28100867   DOI: 10.1248/bpb.b16-00933
3727  Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM  K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.  Mol Oncol  2017  11(9):1130-1142  PubMed ID: 28544747   DOI: 10.1002/1878-0261.12078
5767  Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, Nakashima K, Tagawa Y, Okazaki S, Matsuura Y, Wakita T, Suzuki T.  Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation.  Oncotarget  2017  8(33):53899-53915  PubMed ID: 28903311   DOI: 10.18632/oncotarget.19108
3923  Yoshitsugu OHNUKI, Takumi KONDO, Hiroshi KUROSAWA  ROCK INHIBITOR Y-27632 USED DURING CELL AGGREGATE FORMATION ADVERSELY AFFECTS THE EARLY CARDIAC DIFFERENTIATION OF HUMAN iPS CELLS  Tiss Cult Res Commun  2017  36:21–29    DOI: 10.11418/jtca.36.21
14252  Maki T, Ikeda H, Kuroda A, Kyogoku N, Yamamura Y, Tabata Y, Abiko T, Tsuchikawa T, Hida Y, Shichinohe T, Tanaka E, Kaga K, Hatanaka K, Matsuno Y, Imai N, Hirano S.  Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification  Int J Oncol  2017  50(1):129-140.  PubMed ID: 27922671   DOI: 10.3892/ijo.2016.3786
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