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RCB1954 : T98G  update : 2018/08/01
CommentHuman cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0471
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 61 years
Tissue brain
Case history glioblastoma multiforme tumor
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0471)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 2
User's Publication 14


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Reference
3267  Stein, G H  T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro.  J Cell Physiol  1979  99:43-54  PubMed ID: 222778
4618  Stein GH, Yanishevsky RM.  Quiescent human diploid cells can inhibit entry into S phase in replicative nuclei in heterodikaryons.  Proc Natl Acad Sci U S A  1981  78(5):3025-9  PubMed ID: 6265932

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User's Publication
7299  Miki Y, Akimoto J, Moritake K, Hironaka C, Fujiwara Y.  Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.  Lasers Med Sci  2015  30:1739-45  PubMed ID: 26109138
7547  Miki Y., Akimoto J., Sato A., Fujiwara Y.  Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death.  Fundamental Toxicological Sciences  2015  2:111-116 
7557  Seki K, Kinashi Y, Takahashi S.  Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma.  Anticancer Res.  2015  35:169-74  PubMed ID: 25550548
7905  Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C.  MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.  Cell Death Dis  2011  1:e60  PubMed ID: 21364665
8109  Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H.  Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.  Biochem. Genet.  2010  48:970-86  PubMed ID: 20862607
10052  Shinoda Y, Takahashi T, Akimoto J, Ichikawa M, Yamazaki H, Narumi A, Yano S, Fujiwara Y.  Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.  J Toxicol Sci  2017  42:111-119  PubMed ID: 28070104
10523  Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.  Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis.  Sci Rep  2017  7:11406  PubMed ID: 28900243
10559  Goji T, Takahara K, Negishi M, Katoh H.  Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.  J. Biol. Chem.  2017  292:19721-19732  PubMed ID: 29038291
11419  Feng S, Cai X, Li Y, Jian X, Zhang L, Li B.  Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.  J. Exp. Clin. Cancer Res.  2019    PubMed ID: 30728039
4353  Peng F, Wang X, Shu M, Yang M, Wang L, Ouyang Z, Shen C, Hou X, Zhao B, Wang X, Zhang LW, Liu Y, Zhao S.  Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis.  Cell. Physiol. Biochem.  2018    PubMed ID: 29843152
4375  Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H.  Aberrant methylation and silencing of the SPINT2 gene in high-grade gliomas.  Cancer Sci.  2018    PubMed ID: 29987920
4503  Ishiguro Y, Kobayashi M, Ideno M, Narumi K, Furugen A, Iseki K.  Valproate sensitizes human glioblastoma cells to 3-bromopyruvate-induced cytotoxicity.  Int J Pharm  2018  551(1-2):97-102  PubMed ID: 30138705
4672  Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y.  Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-wild-type Diffuse Astrocytic Gliomas.  Cancer Res  2019  79(19):4814-4827  PubMed ID: 31431463
6415  Kageyama-Yahara N, Yamamichi N, Takahashi Y, Takeuchi C, Matsumoto Y, Sakaguchi Y, Koike K.  Tandem repeats of the 5' flanking region of human MUC5AC have a role as a novel enhancer in MUC5AC gene expression.  Biochem Biophys Rep  2019  18:100632  PubMed ID: 30993217



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