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RCB1954 : T98G  update : 2018/08/01
CommentHuman cell line derived from glioblastoma multiforme (Caucasian). Hyperpentaploid chromosome count. TKG0471 (Deposited from Tohoku Univ.).
Comment from the depositor
Restriction (Category)a
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0471
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 61 years
Tissue brain
Case history glioblastoma multiforme tumor
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0471)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 1
User's Publication 9


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Reference
Stein, G H  T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro.  J Cell Physiol  1979  99:43-54 

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User's Publication
Miki Y, Akimoto J, Moritake K, Hironaka C, Fujiwara Y.  Photodynamic therapy using talaporfin sodium induces concentration-dependent programmed necroptosis in human glioblastoma T98G cells.  Lasers Med Sci  2015  30:1739-45  PubMed ID: 26109138
Miki Y., Akimoto J., Sato A., Fujiwara Y.  Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death.  Fundamental Toxicological Sciences  2015  2:111-116 
Seki K, Kinashi Y, Takahashi S.  Influence of p53 status on the effects of boron neutron capture therapy in glioblastoma.  Anticancer Res.  2015  35:169-74  PubMed ID: 25550548
Tomiyama A, Tachibana K, Suzuki K, Seino S, Sunayama J, Matsuda KI, Sato A, Matsumoto Y, Nomiya T, Nemoto K, Yamashita H, Kayama T, Ando K, Kitanaka C.  MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.  Cell Death Dis  2011  1:e60  PubMed ID: 21364665
Ohsaka Y, Yogosawa S, Nakanishi R, Sakai T, Nishino H.  Polymorphisms in promoter sequences of the p15 ( INK4B ) and PTEN genes of normal Japanese individuals.  Biochem. Genet.  2010  48:970-86  PubMed ID: 20862607
Shinoda Y, Takahashi T, Akimoto J, Ichikawa M, Yamazaki H, Narumi A, Yano S, Fujiwara Y.  Comparative photodynamic therapy cytotoxicity of mannose-conjugated chlorin and talaporfin sodium in cultured human and rat cells.  J Toxicol Sci  2017  42:111-119  PubMed ID: 28070104
Asano M, Tanaka S, Sakaguchi M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K.  Normothermic Microwave Irradiation Induces Death of HL-60 Cells through Heat-Independent Apoptosis.  Sci Rep  2017  7:11406  PubMed ID: 28900243
Goji T, Takahara K, Negishi M, Katoh H.  Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation.  J. Biol. Chem.  2017  292:19721-19732  PubMed ID: 29038291
Feng S, Cai X, Li Y, Jian X, Zhang L, Li B.  Tripartite motif-containing 14 (TRIM14) promotes epithelial-mesenchymal transition via ZEB2 in glioblastoma cells.  J. Exp. Clin. Cancer Res.  2019    PubMed ID: 30728039



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