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RCB1949 : TE-5  update : 2018/08/01
CommentHuman cell line derived from poorly differntiated esophageal squamous cell carcinoma. Not transplantable to nude mouse. TKG0256 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsA prior written permission of the approver(Originator) is necessary for any kind of use including academic use and for-profit use.
Remarks
approver's address
×
English
Address
Koseikai Hospital

320-1 Yamada, Kawagoe city, Saitama 350-8588, Japan
Dr.Nishihira, Tetsuro
Fax. +81-49-223-5713
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Originator Nishihira, Tetsuro
Year of deposit 2004
Original cell TKG0256
Animal human < Mammals
Genus homo
Species sapiens
Tissue esophagus
Case history squamous carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0256)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 2
User's Publication 18


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Reference
3174    Hay, Park, Gazdar, Ed.  Atlas of Human Tumor Cell Lines  1994  269-282 
3173  Molecular and cellular features of esophageal cancer cells.  Nishihira T, Hashimoto Y, Katayama M, Mori S, Kuroki T  J Cancer Res Clin Oncol  1993  119:441-9  PubMed ID: 8509434

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User's Publication
7202  Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.  Kikuchi O, Ohashi S, Nakai Y, Nakagawa S, Matsuoka K, Kobunai T, Takechi T, Amanuma Y, Yoshioka M, Ida T, Yamamoto Y, Okuno Y, Miyamoto S, Nakagawa H, Matsubara K, Chiba T, Muto M.  Am J Cancer Res  2015  5:2431-40  PubMed ID: 26396918
7382  The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.  Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.  BMC Cancer  2015  15:82  PubMed ID: 25884729
7493  REG Iα activates c-Jun through MAPK pathways to enhance the radiosensitivity of squamous esophageal cancer cells.  Wakita A, Motoyama S, Sato Y, Koyota S, Usami S, Yoshino K, Sasaki T, Imai K, Saito H, Minamiya Y.  Tumour Biol.  2015  36:5249-54  PubMed ID: 25656613
8377  Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells.  Usami S, Motoyama S, Koyota S, Wang J, Hayashi-Shibuya K, Maruyama K, Takahashi N, Saito H, Minamiya Y, Takasawa S, Ogawa J, Sugiyama T.  Biochem. Biophys. Res. Commun.  2010  392:4-8  PubMed ID: 20056108
8430  Phosphatase of regenerating liver-3 as a convergent therapeutic target for lymph node metastasis in esophageal squamous cell carcinoma.  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Watanabe M.  Int. J. Cancer  2009  127:543-54  PubMed ID: 19960436
9599  Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma.  Kikuchi O, Ohashi S, Horibe T, Kohno M, Nakai Y, Miyamoto S, Chiba T, Muto M, Kawakami K.  Sci Rep  2016  6:22452  PubMed ID: 26956916
9724  Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.  Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.  Br. J. Cancer  2016  115:66-75  PubMed ID: 27310703
10116  RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium.  Akagi I, Ishibashi O.  Genom Data  2017  12:4-6  PubMed ID: 28224081
10141  Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.  Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.  Int. J. Cancer  2017  140:2608-2621  PubMed ID: 28233302
10323  PTK7 is a novel oncogenic target for esophageal squamous cell carcinoma.  Liu K, Song G, Zhang X, Li Q, Zhao Y, Zhou Y, Xiong R, Hu X, Tang Z, Feng G.  World J Surg Oncol  2017  15:105  PubMed ID: 28545451
10353  Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.  Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Tumour Biol.  2017  39:1010428317700409  PubMed ID: 28618928
10365  Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma.  Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  Oncol Lett  2017  14:1581-1587  PubMed ID: 28789382
10449  Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.  Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M.  J. Exp. Clin. Cancer Res.  2017  36:101  PubMed ID: 28764725
10798  Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.  Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.  Oncogene  2018  37(26):3471-3484  PubMed ID: 29563607
11092  Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma.  Shin WS, Gim J, Won S, Lee ST.  Sci Rep  2018  8(1):8519  PubMed ID: 29867084
4355  PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.  Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  Cancer Sci.  2018  109(2):412-421  PubMed ID: 29168598
4356  MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway.  Ishibashi O, Akagi I, Ogawa Y, Inui T.  Biochem Biophys Res Commun.  2018  501(2):507-513  PubMed ID: 29738771
11631  LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma.  Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.  Am. J. Pathol.  2019    PubMed ID: 31323188



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