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RCB1945 : HSC-2  update : 2018/08/01
CommentHuman cell line derived from oral squamous cell carcinoma occurred in 69-yo, male patient. HLA-A 24/. TKG0487 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Originator Hiraki S
Year of deposit 2004
Original cell TKG0487
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 69 years
Tissue mouth
Case history squamous cell carcinoma of mouth
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0487)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method (0.05% trypsin + 0.02% EDTA) or (0.25% trypsin + 0.02% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 6
User's Publication 125


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Reference
3244  Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T.  Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer.  Oncogene  1995  11:1997-2004  PubMed ID: 7478518
3247  Wu JZ, Adachi I, Watanabe T.  Cytotoxic activity of FK973 against human oral and breast cancer cells.  Chin Med J (Engl)  1991  104:834-837  PubMed ID: 1661225
3245  Ohara M.  Restriction fragment length polymorphism of the c-fms gene in the human oral squamous cell carcinomas.  Hiroshima J Med Sci  1994  43(1):23-9  PubMed ID: 7912238
3248  Ichijo H, Momose F, Miyazono K  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718
3243  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303
3285  Kitamura M, Shirasawa T, Mitarai T, Muramatsu T, Maruyama N  A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.  Am J Pathol  1993  142:425-31  PubMed ID: 8434639

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User's Publication
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690
7442  Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, Aoba T, Soeno Y.  Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model.  J. Oral Pathol. Med.  2015  44:656-68  PubMed ID: 25765182
7601  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286
7764  Otsuki S, Sugiyama K, Amano O, Yasui T, Sakagami H.  Negative regulation of NaF-induced apoptosis by Bad-CAII complex.  Toxicology  2011  287:131-6  PubMed ID: 21708216
7967  Iwasaka K, Tomita K, Ozawa Y, Katayama T, Sakagami H.  Effect of CO2 laser irradiation on hormesis induction in cultured oral cells.  In Vivo  2011  25:93-8  PubMed ID: 21282740
8085  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  In Vivo  2010  24:735-43  PubMed ID: 20952742
8406  Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y.  NOD1 and NOD2 mediate sensing of periodontal pathogens.  J. Dent. Res.  2009  89:186-91  PubMed ID: 20040739
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9640  Wang M, Miura Y, Tsuchihashi K, Miyano K, Nagano O, Yoshikawa M, Tanabe A, Makino J, Mochida Y, Nishiyama N, Saya H, Cabral H, Kataoka K.  Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.  J Control Release  2016  230:26-33  PubMed ID: 27040816
9694  Harada K, Ferdous T, Harada T, Ueyama Y.  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058
9770  Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y.  Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.  BMC Cancer  2016  16:548  PubMed ID: 27464948
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902
9896  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918
9900  Harada K, Ferdous T, Ueyama Y.  Gimeracil Exerts Radiosensitizing Effects on Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo.  Anticancer Res.  2016  36:5923-5930  PubMed ID: 27793917
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461
10044  Ohkoshi E, Umemura N.  Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.  Int. J. Oncol.  2017  50:387-395  PubMed ID: 28035370
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677
10384  Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, Iwata C, Nagano O, Saya H, Nishiyama N, Kataoka K, Yamasoba T.  cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.  J Control Release  2017  261:275-286  PubMed ID: 28666729
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425
10395  Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404
10572  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797
10579  Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A.  Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma.  Anticancer Res.  2017  37:6119-6123  PubMed ID: 29061792
10600  Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y.  Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.  Int J Mol Sci  2017  18:  PubMed ID: 29112119
10618  Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y.  Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.  J. Periodont. Res.  2018  53:353-361  PubMed ID: 29159877
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705
10683  Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.  Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.  Biochem. Biophys. Res. Commun.  2018  495:2303-2309  PubMed ID: 29278708
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707
10727  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.  Anticancer Res.  2018  38:763-770  PubMed ID: 29374700
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549
11036    Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation  Int J Cancer Oncol  2017  4: 225- 230 
11086  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Anticancer Res.  2018    PubMed ID: 29848675
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018    PubMed ID: 29936454
11115  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Anticancer Res.  2018    PubMed ID: 29970510
11147  Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.  Anticancer Res.  2018    PubMed ID: 30061209
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018    PubMed ID: 30061210
11192  Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S.  Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice.  Tohoku J. Exp. Med.  2018    PubMed ID: 30158369
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493
11272  Sakagami H, Sugimoto M, Kanda Y, Murakami Y, Amano O, Saitoh J, Kochi A.  Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol.  Medicines (Basel)  2018    PubMed ID: 30384403
11300  Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.  Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma.  Int. J. Oncol.  2019    PubMed ID: 30431077
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
11363  Nishioka T, Tada H, Ibaragi S, Chen C, Sasano T.  Nicotine exposure induces the proliferation of oral cancer cells through the α7 subunit of the nicotinic acetylcholine receptor.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30598264
4078  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Medicinal Chemistry Research  2018  27:2366–2378 
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558
4235  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Oncotarget  2018    PubMed ID: 30333913
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845
4239  Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D.  Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma.  Int. J. Oncol.  2018    PubMed ID: 29344674
5323  Jitsuno M, Yokosuka A, Hashimoto K, Amano O, Sakagami H, Mimaki Y.  Chemical constituents of Lycoris albiflora and their cytotoxic activities.  Nat Prod Commun  2011  6(2):187-92  PubMed ID: 21425671
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695
5611  Wakabayashi H, Narita T, Suga A, Sakagami H.  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973
5809  Ninomiya K et al  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  J Nat Med   2016  0(3):435-51  PubMed ID: 27178360
6025  Abé T, Maruyama S, Yamazaki M, Xu B, Babkair H, Sumita Y, Cheng J, Yamamoto T, Saku T.  Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia.  Exp Mol Pathol  2017  102(2):327-336  PubMed ID: 28242296
6026  Morishima H, Washio J, Kitamura J, Shinohara Y, Takahashi T, Takahashi N.  Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.  Sci Rep.  2017  7(1):10092  PubMed ID: 28855722
6029  Ishida S et al  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725
6032  Tada H, Shimizu T, Nagaoka I, Takada H.  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
6042  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Mol Carcinog  2016  Jun;55(6):1037-47  PubMed ID: 26086332
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864
6056  Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y.  Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.  Anticancer Res  2014  34(8):4117-20  PubMed ID: 25075037
6040  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Ando Y, Kanda Y, Hibino Y, Nakajima H, Sakagami H.  Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line.  In Vivo  2014  28(2):209-15  PubMed ID: 24632975
6038  Hiroshi Sakagami et al  Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line  Metabolomics  2014  10:270–279 
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221
5859  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035
5605  Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.  Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.  PLoS One  2014  9(12):e114121  PubMed ID: 25437003
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069
5315  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705
5190  Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.  Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.  Acta Med Okayama  2013  67(3):153-64  PubMed ID: 23804138
5122  Iida S, Shimada J, Sakagami H.  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687
5110  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234
6065  Miyazaki Y, Fujinami M, Inoue H, Kikuchi K, Ide F, Kusama K.  Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.  J Oral Sci  2013  55(4):293-9  PubMed ID: 24351917
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790
6072  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564
6076  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247
6078  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548
6081  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  BMC Cancer  2013  13:555  PubMed ID: 24261884
6083  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 4045666
6087  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889
6088  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311
6089  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  J Oral Sci  2012  54(3):241-50  PubMed ID: 2304703
6091  Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T.  Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.  Microbes Infect  2012  14(11):916-21  PubMed ID: 22561467
6095  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894
6098  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Tumour Biol  2012  33(1):183-94  PubMed ID: 2081310
6116  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983
6119  Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.  Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.  Biochem Biophys Res Commun  2010  391(2):1192-6  PubMed ID: 20004645
6120  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673
6122  Nomi N, Kodama S, Suzuki M.  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466
6123  Yuji Miyazaki et al  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  J Cancer Sci Ther  2010  2(2) :26-32 
6127  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319
6128  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186
6129  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354
6136  Okamura M, Shimada J, Sakagami H.  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853
6138  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Anticancer Res  2008  28(2A):1069-78 
6140  Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T.  Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.  In Vivo  2008  2(4):471-6  PubMed ID: 18712174
6141  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558
6142  Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H.  Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line.  Anticancer Res  2007  27(5A):3331-7  PubMed ID: 17970078
6143  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225
6148  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456
6152  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H.  Cytotoxic activity of azulenequinones against human oral tumor cell lines.  Anticancer Res  2005  25(1A):305-12  PubMed ID: 15816552
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309



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