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Cell No. : Cell Name
RCB1945 : HSC-2  update : 2023/01/05
CommentHuman cell line derived from oral squamous cell carcinoma occurred in 69-yo, male patient. HLA-A 24/. TKG0487 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Hiraki S
Year of deposit 2004
Original cell TKG0487
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 69 years
Tissue mouth
Disease name squamous cell carcinoma of mouth
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0487)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1287
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS
Antibiotics Free
Passage method (0.05% Trypsin + 0.02% EDTA) or (0.25% Trypsin + 0.04% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 6
User's Publication 203


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Reference
3244  Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T.  Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer.  Oncogene  1995  11:1997-2004  PubMed ID: 7478518  
3245  Ohara M.  Restriction fragment length polymorphism of the c-fms gene in the human oral squamous cell carcinomas.  Hiroshima J Med Sci  1994  43(1):23-9  PubMed ID: 7912238  
3285  Kitamura M, Shirasawa T, Mitarai T, Muramatsu T, Maruyama N  A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.  Am J Pathol  1993  142:425-31  PubMed ID: 8434639  
3247  Wu JZ, Adachi I, Watanabe T.  Cytotoxic activity of FK973 against human oral and breast cancer cells.  Chin Med J (Engl)  1991  104:834-837  PubMed ID: 1661225  
3248  Ichijo H, Momose F, Miyazono K  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718   DOI: 10.1016/0014-4827(90)90090-w
3243  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303   DOI: 10.1111/j.1600-0714.1989.tb01570.x

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User's Publication
21577  Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA.  In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations.  Front Pharmacol  2024  15:1325272  PubMed ID: 38303989   DOI: 10.3389/fphar.2024.1325272
19875  Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H.  A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs  Medicines (Basel)  2023  10(7):43  PubMed ID: 37505064   DOI: 10.3390/medicines10070043
21184  Chan NN, Yamazaki M, Maruyama S, Abé T, Haga K, Kawaharada M, Izumi K, Kobayashi T, Tanuma JI.  Cholesterol Is a Regulator of CAV1 Localization and Cell Migration in Oral Squamous Cell Carcinoma.  Int J Mol Sci  2023  24(7)  PubMed ID: 37047005   DOI: 10.3390/ijms24076035
21370  Yamada T, Yamamori Y, Matsuda N, Nagamune H, Ohkura K, Tomoyasu T, Tabata A.  Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors.  Sci Rep  2023  13(1):13720  PubMed ID: 37608082   DOI: 10.1038/s41598-023-40981-1
21380  Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I.  Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia.  Anticancer Res  2023  43(8):3429-3439  PubMed ID: 37500171   DOI: 10.21873/anticanres.16518
21527  Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T.  New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines.  Antioxidants (Basel)  2023  12(11)  PubMed ID: 38001804   DOI: 10.3390/antiox12111951
20382  Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y.  Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers.  Oncol Rep  2022  47(1)  PubMed ID: 34738627   DOI: 10.3892/or.2021.8216
20513  Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y.  Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma.  Oncoimmunology  2022  11(1):2021619  PubMed ID: 35003900   DOI: 10.1080/2162402X.2021.2021619
20544  Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H.  Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid.  Anticancer Res  2022  42(2):781-790  PubMed ID: 35093876   DOI: 10.21873/anticanres.15536
20559  Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis.  Oncol Lett  2022  23(2):49  PubMed ID: 34992682   DOI: 10.3892/ol.2021.13167
16180  Katsuhiro Asaka, Akira Fukatsu, Chiaki Komine  The Effectiveness of a Portable Fluorescence Spectrophotometer for Early Detection of Oral Cancer  Open Journal of Stomatology  2022  12:30-31    DOI: 10.4236/ojst.2022.121003
16203  Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T.  Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis  Cancer Sci   2022  113(2):609-621  PubMed ID: 34874595   DOI: 10.1111/cas.15225
20638  Shahbaz K, Asif JA, Liszen T, Nurul AA, Alam MK.  Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line.  Biomed Res Int  2022  2022:5792830  PubMed ID: 35233390   DOI: 10.1155/2022/5792830
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
20658  Tabata A, Shirai R, Miki H, Nishikawa Y, Kashima T, Aoyama T, Murakami S, Azuma M, Tomoyasu T, Nagamune H.  Hapten-labeled fusion-polymerase chain reaction of multiple marker genes for the application of immunochromatographic test.  J Biosci Bioeng  2022    PubMed ID: 35450786   DOI: 10.1016/j.jbiosc.2022.03.006
20815  Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR.  Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells.  Medicines (Basel)  2022  9(6)  PubMed ID: 35736248   DOI: 10.3390/medicines9060035
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20965  Morisaka H, Takaishi M, Akira S, Sano S.  Keratinocyte Regnase-1, a down-regulator of skin inflammation, contributes to protection against tumor promotion by limiting COX-2 expression.  J Invest Dermatol  2022    PubMed ID: 36470473   DOI: 10.1016/j.jid.2022.11.007
13361  Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T.  Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.  Fitoterapia  2021    PubMed ID: 33246033   DOI: 10.1016/j.fitote.2020.104780
20020  Shishido K, Kuroishi T, Sugawara S.  P2 purinergic receptor signaling and interleukin-1 synergistically induce interleukin-6 production in a human oral squamous carcinoma cell line.  J Oral Biosci  2021    PubMed ID: 33497843   DOI: 10.1016/j.job.2021.01.004
13580  Matsumoto A, Tabata A, Ohkura K, Oda H, Kodama C, Ohkuni H, Takao A, Kikuchi K, Tomoyasu T, Nagamune H.  Molecular characteristics of an adhesion molecule containing cholesterol-dependent cytolysin-motif produced by mitis group streptococci  Microbiol Immunol  2021  65(2):61-75  PubMed ID: 33331679   DOI: 10.1111/1348-0421.12868
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306   DOI: 10.1038/s41598-021-85242-1
13776  Hamilton KL, Sheehan SA, Retzbach EP, Timmerman CA, Gianneschi GB, Tempera PJ, Balachandran P, Goldberg GS.  Effects of Maackia amurensis seed lectin (MASL) on oral squamous cell carcinoma (OSCC) gene expression and transcriptional signaling pathways  J Cancer Res Clin Oncol  2021  147(2):445-457  PubMed ID: 33205348   DOI: 10.1007/s00432-020-03456-8
20350  Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI.  Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression.  Transl Oncol  2021  14(12):101236  PubMed ID: 34624685   DOI: 10.1016/j.tranon.2021.101236
15868  Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K.  Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma  Oncol Lett  2021  22(4):730  PubMed ID: 34429770   DOI: 10.3892/ol.2021.12991
20455  Harada K, Ferdous T, Mishima K.  Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells.  Anticancer Res  2021  41(12):6039-6049  PubMed ID: 34848458   DOI: 10.21873/anticanres.15423
16099  Saito K, Mitsui A, Sumardika IW, Yokoyama Y, Sakaguchi M, Kondo E.  PLOD2-driven IL-6/STAT3 signaling promotes the invasion and metastasis of oral squamous cell carcinoma via activation of integrin β1  Int J Oncol  2021  58(6):29  PubMed ID: 33887877   DOI: 10.3892/ijo.2021.5209
16112  Akyu Takei R, Tomihara K, Yamazaki M, Moniruzzaman R, Heshiki W, Sekido K, Tachinami H, Sakurai K, Yonesi A, Imaue S, Fujiwara K, Noguchi M.  Protumor role of estrogen receptor expression in oral squamous cell carcinoma cells  Oral Surg Oral Med Oral Pathol Oral Radiol  2021  132(5):549-565  PubMed ID: 34518137   DOI: 10.1016/j.oooo.2021.04.006
16136  Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K.  Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells  Oncol Rep  2021  45(2):738-751  PubMed ID: 33416174   DOI: 10.3892/or.2020.7896
16139  Kase-Kato I, Asai S, Minemura C, Tsuneizumi K, Oshima S, Koma A, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Molecular Pathogenesis of the Coronin Family: CORO2A Facilitates Migration and Invasion Abilities in Oral Squamous Cell Carcinoma  Int J Mol Sci   2021  22(23):12684  PubMed ID: 34884487   DOI: 10.3390/ijms222312684
16174  Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U.  Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts  Molecules  2021  26(23):7132  PubMed ID: 34885719   DOI: 10.3390/molecules26237132
16195  Yamali C, Sakagami H, Uesawa Y, Kurosaki K, Satoh K, Masuda Y, Yokose S, Ece A, Bua S, Angeli A, Supuran CT, Gul HI.  Comprehensive study on potent and selective carbonic anhydrase inhibitors: Synthesis, bioactivities and molecular modelling studies of 4-(3-(2-arylidenehydrazine-1-carbonyl)-5-(thiophen-2-yl)-1H-pyrazole-1-yl) benzenesulfonamides  Eur J Med Chem  2021  217:113351  PubMed ID: 33744685   DOI: 10.1016/j.ejmech.2021.113351
16196  Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S.  Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue  Medicines (Basel)  2021  8(7):33  PubMed ID: 34206186   DOI: 10.3390/medicines8070033
16200  Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR.  Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring  Medicines (Basel)  2021  8(12):78  PubMed ID: 34940290   DOI: 10.3390/medicines8120078
16206  Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2021  22(18):9947  PubMed ID: 34576110   DOI: 10.3390/ijms22189947
16862  Kawasaki M, Sakabe T, Kodani I, Umekita Y.  Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma  Anticancer Res  2021  41(9):4563-4570  PubMed ID: 34475084   DOI: 10.21873/anticanres.15269
16975  Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K.  Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling  Anticancer Res  2021  41(4):1821-1830  PubMed ID: 33813387   DOI: 10.21873/anticanres.14948
11844  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Oral Dis  2020  26(4):745-755  PubMed ID: 31603606   DOI: 10.1111/odi.13210
6954  Hayashi H, Chiba T, Mihara-Tomiyama N, Negishi T, Kodama Y, Sakashita H, Imai K.  Domain structures of mucosa-associated lymphoid tissue lymphoma translocation 1 protein for nuclear localization in oral carcinoma cells and the proliferation inhibition.  Biochem Biophys Res Commun  2020  522(3):799-804  PubMed ID: 31791579   DOI: 10.1016/j.bbrc.2019.11.171
11965  Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T.  The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.  Lab. Invest.  2020    PubMed ID: 31857698   DOI: 10.1038/s41374-019-0357-z
12037  Nakagawa F, Higashi S, Ando E, Ohsumi T, Watanabe S, Takeuchi H.  Modification of TRPV4 activity by acetaminophen.  Heliyon  2020    PubMed ID: 32051870   DOI: 10.1016/j.heliyon.2020.e03301
13013  Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H.  Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.  In Vivo  2020    PubMed ID: 32354886   DOI: 10.21873/invivo.11869
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13205  Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H.  Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro.  Anticancer Res  2020    PubMed ID: 32878776   DOI: 10.21873/anticanres.14491
13427  Thahomina Khan, Kazunori Igarashi, Ami Tanabe, Taiki Miyazawa, Shigeto Fukushima, Yutaka Miura, Yu Matsumoto, Tatsuya Yamasoba, Akira Matsumoto, Horacio Cabral, and Kazunori Kataoka  Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid To Eradicate Cancer Stem-like Cells  ACS Appl. Bio Mater.  2020    PubMed ID: 35021680   DOI: 10.1021/acsabm.0c00530
13775  Al-Tayar BA, Ahmad A, Yusoff ME, Abdullah SF, Mohamad NK, Md Hashim SN, Kishida S, Kishida M, Nakamura N, Kibe T, Harun MH.  Cytotoxic Effects of Betel Quid and Areca Nut Aqueous Extracts on Mouse Fibroblast, Human Mouth-Ordinary-Epithelium 1 and Human Oral Squamous Cell Carcinoma Cell Lines  Asian Pac J Cancer Prev  2020  21(4):1005-1009  PubMed ID: 32334462   DOI: 10.31557/APJCP.2020.21.4.1005
13783  Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O.  Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy  Cancer Sci  2020  111(1):127-136.  PubMed ID: 31692172   DOI: 10.1111/cas.14224
13853  Rizwan Mahmood, Jawaad Ahmed Asif, Wan Nazatul, Shima Shahidan  Stingless-bee (Trigona itama) honey adversely impacts the growth of oral squamous cell carcinoma cell lines (HSC-2)  European Journal of Integrative Medicine  2020  37    DOI: 10.1016/j.eujim.2020.101162
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72    DOI: 10.1002/osi2.1044
11300  Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.  Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma.  Int. J. Oncol.  2019    PubMed ID: 30431077   DOI: 10.3892/ijo.2018.4631
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341   DOI: 10.1016/j.bbrc.2018.12.066
11363  Nishioka T, Tada H, Ibaragi S, Chen C, Sasano T.  Nicotine exposure induces the proliferation of oral cancer cells through the α7 subunit of the nicotinic acetylcholine receptor.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30598264   DOI: 10.1016/j.bbrc.2018.12.154
11620  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Anticancer Res.  2019    PubMed ID: 31262875   DOI: 10.21873/anticanres.13497
6911  Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H.  β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.  J Oral Microbiol  2019  11(1):1609839.   PubMed ID: 31105901   DOI: 10.1080/20002297.2019.1609839
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558   DOI: 10.1016/j.yexcr.2019.111622
9726  Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano   Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla  J Nat Prod  2019  82(10):2682-2695  PubMed ID: 31532650   DOI: 10.1021/acs.jnatprod.9b00073
9890  Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa  Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement  J Cancer  2019  10(16):3728-3734  PubMed ID: 31333790   DOI: 10.7150/jca.32281
11907  Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.  Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.  Dis. Markers  2019    PubMed ID: 31019584   DOI: 10.1155/2019/8040361
11931  Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs.  Anticancer Res.  2019    PubMed ID: 31810932   DOI: 10.21873/anticanres.13882
11933  Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones.  Anticancer Res.  2019    PubMed ID: 31810912   DOI: 10.21873/anticanres.13862
12456  Bilginer S, Gul HI, Erdal FS, Sakagami H, Levent S, Gulcin I, Supuran CT.  Synthesis, cytotoxicities, and carbonic anhydrase inhibition potential of 6-(3-aryl-2-propenoyl)-2( 3H)-benzoxazolones  J Enzyme Inhib Med Chem  2019  34(1):1722-1729  PubMed ID: 31576761   DOI: 10.1080/14756366.2019.1670657
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163   DOI: 10.7150/jca.32582
12458  Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O.  Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma  Cancer Sci  2019  110(11):3453-3463  PubMed ID: 31444923   DOI: 10.1111/cas.14182
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408   DOI: 10.3164/jcbn.18-91
16176  Kawano S, Ito K, Yahata K, Kira K, Abe T, Akagi T, Asano M, Iso K, Sato Y, Matsuura F, Ohashi I, Matsumoto Y, Isomura M, Sasaki T, Fukuyama T, Miyashita Y, Kaburagi Y, Yokoi A, Asano O, Owa T, Kishi Y.  A landmark in drug discovery based on complex natural product synthesis  Sci Rep  2019  9(1):8656  PubMed ID: 31209263   DOI: 10.1038/s41598-019-45001-9
16194  Yamali C, Gul HI, Ece A, Bua S, Angeli A, Sakagami H, Sahin E, Supuran CT.  Synthesis, biological evaluation and in silico modelling studies of 1,3,5-trisubstituted pyrazoles carrying benzenesulfonamide as potential anticancer agents and selective cancer-associated hCA IX isoenzyme inhibitors  Bioorg Chem  2019  92:103222.  PubMed ID: 31499260   DOI: 10.1016/j.bioorg.2019.103222
10618  Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y.  Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.  J. Periodont. Res.  2018  53:353-361  PubMed ID: 29159877   DOI: 10.1111/jre.12520
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705   DOI: 10.1016/j.bbrc.2017.12.138
10683  Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.  Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.  Biochem. Biophys. Res. Commun.  2018  495:2303-2309  PubMed ID: 29278708   DOI: 10.1016/j.bbrc.2017.12.136
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707   DOI: 10.21873/anticanres.12289
10727  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.  Anticancer Res.  2018  38:763-770  PubMed ID: 29374700   DOI: 10.21873/anticanres.12282
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312   DOI: 10.1016/j.yexcr.2018.03.041
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549   DOI: 10.21873/invivo.11264
11086  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675   DOI: 10.21873/anticanres.12593
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454   DOI: 10.21873/invivo.11303
11115  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510   DOI: 10.21873/anticanres.12674
11147  Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.  Anticancer Res.  2018  38(8):4449-4457  PubMed ID: 30061209   DOI: 10.21873/anticanres.12747
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210   DOI: 10.21873/anticanres.12748
11192  Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S.  Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice.  Tohoku J. Exp. Med.  2018  245(4):269-275  PubMed ID: 30158369   DOI: 10.1620/tjem.245.269
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493   DOI: 10.7150/jca.25666
11272  Sakagami H, Sugimoto M, Kanda Y, Murakami Y, Amano O, Saitoh J, Kochi A.  Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol.  Medicines (Basel)  2018    PubMed ID: 30384403   DOI: 10.3390/medicines5040116
4078  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Medicinal Chemistry Research  2018  27:2366–2378    DOI: 10.1007/s00044-018-2242-5
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558   DOI: 10.21873/invivo.11273
4235  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Oncotarget  2018    PubMed ID: 30333913   DOI: 10.18632/oncotarget.26112
4236  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Oncol. Rep.  2018    PubMed ID: 29192320   DOI: 10.3892/or.2017.6105
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845   DOI: 10.3892/mco.2018.1548
4239  Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D.  Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma.  Int. J. Oncol.  2018    PubMed ID: 29344674   DOI: 10.3892/ijo.2018.4247
14708  Arimoto T, Yambe R, Morisaki H, Umezawa H, Kataoka H, Matsui S, Kuwata H.  Influence of excess branched-chain amino acid uptake by Streptococcus mutans in human host cells  FEMS Microbiol Lett  2018  365(3)  PubMed ID: 29240953   DOI: 10.1093/femsle/fnx273
14912  Yun MR, Choi HM, Kang HN, Lee Y, Joo HS, Kim DH, Kim HR, Hong MH, Yoon SO, Cho BC.  ERK-dependent IL-6 autocrine signaling mediates adaptive resistance to pan-PI3K inhibitor BKM120 in head and neck squamous cell carcinoma  Oncogene  2018  37(3):377-388  PubMed ID: 28945228   DOI: 10.1038/onc.2017.339
10044  Ohkoshi E, Umemura N.  Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.  Int. J. Oncol.  2017  50:387-395  PubMed ID: 28035370   DOI: 10.3892/ijo.2016.3821
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246   DOI: 10.1016/j.yexcr.2017.02.026
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172   DOI: 10.1038/srep43379
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328   DOI: 10.1016/j.bbrc.2017.03.050
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260   DOI: 10.21873/anticanres.11412
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269   DOI: 10.21873/anticanres.11421
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988   DOI: 10.3390/molecules22030470
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677   DOI: 10.1248/cpb.c16-00830
10384  Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, Iwata C, Nagano O, Saya H, Nishiyama N, Kataoka K, Yamasoba T.  cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.  J Control Release  2017  261:275-286  PubMed ID: 28666729   DOI: 10.1016/j.jconrel.2017.06.021
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425   DOI: 10.21873/invivo.11099
10395  Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278   DOI: 10.3892/ijo.2017.4050
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404   DOI: 10.7150/jca.18714
10572  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798   DOI: 10.21873/anticanres.12066
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797   DOI: 10.21873/anticanres.12065
10579  Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A.  Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma.  Anticancer Res.  2017  37:6119-6123  PubMed ID: 29061792   DOI: 10.21873/anticanres.12060
10600  Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y.  Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.  Int J Mol Sci  2017  18:  PubMed ID: 29112119   DOI: 10.3390/ijms18112358
11036    Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation  Int J Cancer Oncol  2017  4: 225- 230    DOI: 10.15436/2377-0902.17.1628
6025  Abé T, Maruyama S, Yamazaki M, Xu B, Babkair H, Sumita Y, Cheng J, Yamamoto T, Saku T.  Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia.  Exp Mol Pathol  2017  102(2):327-336  PubMed ID: 28242296   DOI: 10.1016/j.yexmp.2017.02.018
6026  Morishima H, Washio J, Kitamura J, Shinohara Y, Takahashi T, Takahashi N.  Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.  Sci Rep.  2017  7(1):10092  PubMed ID: 28855722   DOI: 10.1038/s41598-017-10893-y
6029  Ishida S et al  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725   DOI: 10.1016/j.bbrc.2016.12.142
12679  Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K.  Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential  Cancer Res  2017  77(9):2363-2374  PubMed ID: 28209617   DOI: 10.1158/0008-5472.CAN-16-2114
14231  Harada K, Ferdous T, Harada T, Takenawa T, Ueyama Y.  Gimeracil enhances the antitumor effect of cisplatin in oral squamous cell carcinoma cells in vitro and in vivo  Oncol Lett  2017  14(3):3349-3356.  PubMed ID: 28927087   DOI: 10.3892/ol.2017.6602
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818  
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959   DOI: 10.7150/jca.13820
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852   DOI: 10.7150/jca.14208
9640  Wang M, Miura Y, Tsuchihashi K, Miyano K, Nagano O, Yoshikawa M, Tanabe A, Makino J, Mochida Y, Nishiyama N, Saya H, Cabral H, Kataoka K.  Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.  J Control Release  2016  230:26-33  PubMed ID: 27040816   DOI: 10.1016/j.jconrel.2016.03.038
9694  Harada K, Ferdous T, Harada T, Ueyama Y.  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058   DOI: 10.3892/ijo.2016.3523
9770  Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y.  Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.  BMC Cancer  2016  16:548  PubMed ID: 27464948   DOI: 10.1186/s12885-016-2416-9
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085  
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902   DOI: 10.21873/anticanres.11164
9896  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918   DOI: 10.21873/anticanres.11180
9900  Harada K, Ferdous T, Ueyama Y.  Gimeracil Exerts Radiosensitizing Effects on Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo.  Anticancer Res.  2016  36:5923-5930  PubMed ID: 27793917   DOI: 10.21873/anticanres.11179
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461   DOI: 10.21873/invivo.10994
5809  Ninomiya K et al  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  J Nat Med   2016  70(3):435-51  PubMed ID: 27178360   DOI: 10.1007/s11418-016-0998-9
6032  Tada H, Shimizu T, Nagaoka I, Takada H.  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607   DOI: 10.2220/biomedres.37.199
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916   DOI: 10.3892/ijo.2015.3305
6042  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332   DOI: 10.1002/mc.22347
12933  Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T.  microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer  Oncotarget  2016  7(7):8223-39  PubMed ID: 26882562   DOI: 10.18632/oncotarget.6972
14162  Yamali C, Gul HI, Sakagami H, Supuran CT.  Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases  J Enzyme Inhib Med Chem  2016  31(sup4):125-131  PubMed ID: 27594305   DOI: 10.1080/14756366.2016.1221825
14178  Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T.  Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra  J Nat Prod  2016  79(4):984-95  PubMed ID: 26938659   DOI: 10.1021/acs.jnatprod.5b01065
14581  Yasukawa M, Fujihara H, Fujimori H, Kawaguchi K, Yamada H, Nakayama R, Yamamoto N, Kishi Y, Hamada Y, Masutani M.  Synergetic Effects of PARP Inhibitor AZD2281 and Cisplatin in Oral Squamous Cell Carcinoma in Vitro and in Vivo  Int J Mol Sci  2016  17(3):272  PubMed ID: 26927065   DOI: 10.3390/ijms17030272
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690  
7442  Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, Aoba T, Soeno Y.  Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model.  J. Oral Pathol. Med.  2015  44:656-68  PubMed ID: 25765182   DOI: 10.1111/jop.12318
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695  
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471   DOI: 10.1016/j.toxrep.2015.09.009
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921   DOI: 10.1186/s12885-015-1577-2
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377   DOI: 10.1371/journal.pone.0142252
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920   DOI: 10.1371/journal.pone.0137923
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166   DOI: 10.1016/j.bbrep.2015.07.008
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483   DOI: 10.1002/mc.22127
6058  Shida-Sakazume T et al  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864   DOI: 10.1371/journal.pone.0120143
15042  Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer  Cancer Med  2015  4(5):759-69  PubMed ID: 25644496   DOI: 10.1002/cam4.418
15186  Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma  Oncoimmunology  2015  4(2):e976077  PubMed ID: 25949874   DOI: 10.4161/2162402X.2014.976077
6056  Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y.  Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.  Anticancer Res  2014  34(8):4117-20  PubMed ID: 25075037  
6040  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Ando Y, Kanda Y, Hibino Y, Nakajima H, Sakagami H.  Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line.  In Vivo  2014  28(2):209-15  PubMed ID: 24632975  
6038  Hiroshi Sakagami et al  Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line  Metabolomics  2014  10:270–279    DOI: 10.1007/s11306-013-0576-z
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221  
5859  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344   DOI: 10.2220/biomedres.35.381
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906  
5778  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469   DOI: 10.1002/mc.22007
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035  
5605  Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.  Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.  PLoS One  2014  9(12):e114121  PubMed ID: 25437003   DOI: 10.1371/journal.pone.0114121
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367  
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069  
5315  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705  
16010  Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice  Oncoscience  2014  1(12):807-20  PubMed ID: 25621296   DOI: 10.18632/oncoscience.101
5190  Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.  Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.  Acta Med Okayama  2013  67(3):153-64  PubMed ID: 23804138   DOI: 10.18926/AMO/50408
5122  Iida S, Shimada J, Sakagami H.  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687  
5110  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061  
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234   DOI: 10.1007/s00432-012-1361-5
6065  Miyazaki Y, Fujinami M, Inoue H, Kikuchi K, Ide F, Kusama K.  Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.  J Oral Sci  2013  55(4):293-9  PubMed ID: 24351917   DOI: 10.2334/josnusd.55.293
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766   DOI: 10.3892/ijo.2012.1677
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790   DOI: 10.1007/s00432-012-1356-2
6072  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564   DOI: 10.1371/journal.pone.0056381
6076  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490   DOI: 10.1371/journal.pone.0085951
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247   DOI: 10.1111/j.1600-0714.2012.01182.x
6078  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548   DOI: 10.1007/s10719-012-9458-2
6081  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  BMC Cancer  2013  13:555  PubMed ID: 24261884   DOI: 10.1186/1471-2407-13-555
6083  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 24045666   DOI: 10.1038/bjc.2013.577
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
16085  Ferdous T, Harada K, Kin T, Harada T, Ueyama Y.  Efficacy of schedule-dependent metronomic S-1 chemotherapy in human oral squamous cell carcinoma cells  Int J Oncol  2013  43(1):271-9  PubMed ID: 23695365   DOI: 10.3892/ijo.2013.1950
16313  Ohkoshi E Amano S  Efficient Utilization of Plant Resources by Alkaline Extraction  Alternative & Integrative Medicine  2013  02    DOI: 10.4172/2327-5162.1000133
6087  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889   DOI: 10.2334/josnusd.54.71
6088  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311   DOI: 10.1002/path.3993
6089  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  J Oral Sci  2012  54(3):241-50  PubMed ID: 23047035   DOI: 10.2334/josnusd.54.241
6091  Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T.  Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.  Microbes Infect  2012  14(11):916-21  PubMed ID: 22561467   DOI: 10.1016/j.micinf.2012.04.015
6095  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894   DOI: 10.3892/ol.2011.473
6098  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Tumour Biol  2012  33(1):183-94  PubMed ID: 22081310   DOI: 10.1007/s13277-011-0261-7
15671  Harada T, Harada K, Ueyama Y.  The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma  Int J Oncol  2012  41(2):565-72  PubMed ID: 22664937   DOI: 10.3892/ijo.2012.1501
15740  Hashimoto T, Soeno Y, Maeda G, Taya Y, Aoba T, Nasu M, Kawashiri S, Imai K.  Progression of oral squamous cell carcinoma accompanied with reduced E-cadherin expression but not cadherin switch  PLoS One  2012  7(10):e4789  PubMed ID: 23110125   DOI: 10.1371/journal.pone.0047899
7601  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286  
7764  Otsuki S, Sugiyama K, Amano O, Yasui T, Sakagami H.  Negative regulation of NaF-induced apoptosis by Bad-CAII complex.  Toxicology  2011  287:131-6  PubMed ID: 21708216   DOI: 10.1016/j.tox.2011.06.007
7967  Iwasaka K, Tomita K, Ozawa Y, Katayama T, Sakagami H.  Effect of CO2 laser irradiation on hormesis induction in cultured oral cells.  In Vivo  2011  25:93-8  PubMed ID: 21282740  
5323  Jitsuno M, Yokosuka A, Hashimoto K, Amano O, Sakagami H, Mimaki Y.  Chemical constituents of Lycoris albiflora and their cytotoxic activities.  Nat Prod Commun  2011  6(2):187-92  PubMed ID: 21425671  
6116  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983   DOI: 10.3892/or.2010.1130
8085  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  In Vivo  2010  24:735-43  PubMed ID: 20952742  
8406  Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y.  NOD1 and NOD2 mediate sensing of periodontal pathogens.  J. Dent. Res.  2010  89:186-91  PubMed ID: 20040739   DOI: 10.1177/0022034509354843
5611  Wakabayashi H, Narita T, Suga A, Sakagami H.  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973  
6119  Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.  Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.  Biochem Biophys Res Commun  2010  391(2):1192-6  PubMed ID: 20004645   DOI: 10.1016/j.bbrc.2009.12.029
6120  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673   DOI: 10.1016/j.bbrc.2009.12.156
6122  Nomi N, Kodama S, Suzuki M.  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466   DOI: 10.3892/or_00000850
6123  Yuji Miyazaki et al  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  J Cancer Sci Ther  2010  2(2) :26-32   
6127  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319  
6128  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186  
6129  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354  
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
6136  Okamura M, Shimada J, Sakagami H.  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853  
6138  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Anticancer Res  2008  28(2A):1069-78  PubMed ID: 18507056  
6141  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558   DOI: 10.1111/j.1349-7006.2008.00838.x
6142  Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H.  Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line.  Anticancer Res  2007  27(5A):3331-7  PubMed ID: 17970078  
6143  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225  
6148  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125  
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158
6152  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H.  Cytotoxic activity of azulenequinones against human oral tumor cell lines.  Anticancer Res  2005  25(1A):305-12  PubMed ID: 15816552  



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