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RCB1945 : HSC-2  update : 2018/08/01
CommentHuman cell line derived from oral squamous cell carcinoma occurred in 69-yo, male patient. HLA-A 24/. TKG0487 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Originator Hiraki S
Year of deposit 2004
Original cell TKG0487
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 69 years
Tissue mouth
Case history squamous cell carcinoma of mouth
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0487)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS
Antibiotics Free
Passage method (0.05% trypsin + 0.02% EDTA) or (0.25% trypsin + 0.02% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 6
User's Publication 127


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Reference
3244  Suppression of tumorigenicity in three different cell lines of human oral squamous cell carcinoma by introduction of chromosome 3p via microcell-mediated chromosome transfer.  Uzawa N, Yoshida MA, Oshimura M, Ikeuchi T.  Oncogene  1995  11:1997-2004  PubMed ID: 7478518
3247  Cytotoxic activity of FK973 against human oral and breast cancer cells.  Wu JZ, Adachi I, Watanabe T.  Chin Med J (Engl)  1991  104:834-837  PubMed ID: 1661225
3245  Restriction fragment length polymorphism of the c-fms gene in the human oral squamous cell carcinomas.  Ohara M.  Hiroshima J Med Sci  1994  43(1):23-9  PubMed ID: 7912238
3248  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Ichijo H, Momose F, Miyazono K  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718
3243  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303
3285  A retinoid responsive cytokine gene, MK, is preferentially expressed in the proximal tubules of the kidney and human tumor cell lines.  Kitamura M, Shirasawa T, Mitarai T, Muramatsu T, Maruyama N  Am J Pathol  1993  142:425-31  PubMed ID: 8434639

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User's Publication
7196  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690
7442  Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model.  Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, Aoba T, Soeno Y.  J. Oral Pathol. Med.  2015  44:656-68  PubMed ID: 25765182
7601  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286
7764  Negative regulation of NaF-induced apoptosis by Bad-CAII complex.  Otsuki S, Sugiyama K, Amano O, Yasui T, Sakagami H.  Toxicology  2011  287:131-6  PubMed ID: 21708216
7967  Effect of CO2 laser irradiation on hormesis induction in cultured oral cells.  Iwasaka K, Tomita K, Ozawa Y, Katayama T, Sakagami H.  In Vivo  2011  25:93-8  PubMed ID: 21282740
8085  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  In Vivo  2010  24:735-43  PubMed ID: 20952742
8406  NOD1 and NOD2 mediate sensing of periodontal pathogens.  Okugawa T, Kaneko T, Yoshimura A, Silverman N, Hara Y.  J. Dent. Res.  2009  89:186-91  PubMed ID: 20040739
9584  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  In Vivo  2016  30:91-7  PubMed ID: 26912818
9616  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9640  Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines.  Wang M, Miura Y, Tsuchihashi K, Miyano K, Nagano O, Yoshikawa M, Tanabe A, Makino J, Mochida Y, Nishiyama N, Saya H, Cabral H, Kataoka K.  J Control Release  2016  230:26-33  PubMed ID: 27040816
9694  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Harada K, Ferdous T, Harada T, Ueyama Y.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058
9770  Induction of artificial cancer stem cells from tongue cancer cells by defined reprogramming factors.  Harada K, Ferdous T, Cui D, Kuramitsu Y, Matsumoto T, Ikeda E, Okano H, Ueyama Y.  BMC Cancer  2016  16:548  PubMed ID: 27464948
9808  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  In Vivo  2016  30:645-50  PubMed ID: 27566085
9892  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902
9896  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918
9900  Gimeracil Exerts Radiosensitizing Effects on Oral Squamous Cell Carcinoma Cells In Vitro and In Vivo.  Harada K, Ferdous T, Ueyama Y.  Anticancer Res.  2016  36:5923-5930  PubMed ID: 27793917
9911  Antiviral and Antitumor Activity of Licorice Root Extracts.  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2016  30:777-785  PubMed ID: 27815461
10044  Induced overexpression of CD44 associated with resistance to apoptosis on DNA damage response in human head and neck squamous cell carcinoma cells.  Ohkoshi E, Umemura N.  Int. J. Oncol.  2017  50:387-395  PubMed ID: 28035370
10148  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10155  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Sci Rep  2017  7:43379  PubMed ID: 28230172
10191  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10197  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260
10201  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269
10206  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Molecules  2017  22:  PubMed ID: 28294988
10241  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677
10384  cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.  Miyano K, Cabral H, Miura Y, Matsumoto Y, Mochida Y, Kinoh H, Iwata C, Nagano O, Saya H, Nishiyama N, Kataoka K, Yamasoba T.  J Control Release  2017  261:275-286  PubMed ID: 28666729
10386  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  In Vivo  2017  31:591-598  PubMed ID: 28652425
10395  Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma.  Takada H, Ibaragi S, Eguchi T, Okui T, Obata K, Masui M, Morisawa A, Takabatake K, Kawai H, Yoshioka N, Hassan NMM, Shimo T, Hu GF, Nagatsuka H, Sasaki A.  Int. J. Oncol.  2017  51:625-632  PubMed ID: 28656278
10418  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404
10572  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798
10576  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797
10579  Role of Neurokinin 3 Receptor Signaling in Oral Squamous Cell Carcinoma.  Obata K, Shimo T, Okui T, Matsumoto K, Takada H, Takabatake K, Kunisada Y, Ibaragi S, Yoshioka N, Kishimoto K, Nagatsuka H, Sasaki A.  Anticancer Res.  2017  37:6119-6123  PubMed ID: 29061792
10600  Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.  Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y.  Int J Mol Sci  2017  18:  PubMed ID: 29112119
10618  Crystalline structure of pulverized dental calculus induces cell death in oral epithelial cells.  Ziauddin SM, Yoshimura A, Montenegro Raudales JL, Ozaki Y, Higuchi K, Ukai T, Kaneko T, Miyazaki T, Latz E, Hara Y.  J. Periodont. Res.  2018  53:353-361  PubMed ID: 29159877
10682  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705
10683  Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma.  Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H.  Biochem. Biophys. Res. Commun.  2018  495:2303-2309  PubMed ID: 29278708
10724  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707
10727  Quantitative Structure-Cytotoxicity Relationship of 2-Azolylchromones.  Sakagami H, Okudaira N, Uesawa Y, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2018  38:763-770  PubMed ID: 29374700
10806  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10829  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2018  32:479-486  PubMed ID: 29695549
11036  Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation    Int J Cancer Oncol  2017  4: 225- 230 
11086  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675
11110  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454
11115  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510
11147  Quantitative Structure-Cytotoxicity Relationship of Pyrano[4,3-b]chromones.  Nagai J, Shi H, Kubota Y, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Anticancer Res.  2018  38(8):4449-4457  PubMed ID: 30061209
11148  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210
11192  Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice.  Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S.  Tohoku J. Exp. Med.  2018  245(4):269-275  PubMed ID: 30158369
11226  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2018    PubMed ID: 30271493
11272  Changes in Metabolic Profiles of Human Oral Cells by Benzylidene Ascorbates and Eugenol.  Sakagami H, Sugimoto M, Kanda Y, Murakami Y, Amano O, Saitoh J, Kochi A.  Medicines (Basel)  2018    PubMed ID: 30384403
11300  Nicotine promotes lymph node metastasis and cetuximab resistance in head and neck squamous cell carcinoma.  Shimizu R, Ibaragi S, Eguchi T, Kuwajima D, Kodama S, Nishioka T, Okui T, Obata K, Takabatake K, Kawai H, Ono K, Okamoto K, Nagatsuka H, Sasaki A.  Int. J. Oncol.  2019    PubMed ID: 30431077
11354  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
11363  Nicotine exposure induces the proliferation of oral cancer cells through the α7 subunit of the nicotinic acetylcholine receptor.  Nishioka T, Tada H, Ibaragi S, Chen C, Sasano T.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30598264
4078  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Medicinal Chemistry Research  2018  27:2366–2378 
4173  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vivo  2018    PubMed ID: 29695558
4235  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Oncotarget  2018    PubMed ID: 30333913
4236  Combined SN-38 and gefitinib treatment promotes CD44 degradation in head and neck squamous cell carcinoma cells.  Nanbu T, Umemura N, Ohkoshi E, Nanbu K, Sakagami H, Shimada J.  Oncol. Rep.  2018    PubMed ID: 29192320
4237  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Mol Clin Oncol  2018    PubMed ID: 29456845
4239  Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR‑138 and releasing EZH2 in oral squamous cell carcinoma.  Hong Y, He H, Sui W, Zhang J, Zhang S, Yang D.  Int. J. Oncol.  2018    PubMed ID: 29344674
5323  Chemical constituents of Lycoris albiflora and their cytotoxic activities.  Jitsuno M, Yokosuka A, Hashimoto K, Amano O, Sakagami H, Mimaki Y.  Nat Prod Commun  2011  6(2):187-92  PubMed ID: 21425671
5422  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695
5611  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  Wakabayashi H, Narita T, Suga A, Sakagami H.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973
5809  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  Ninomiya K et al  J Nat Med   2016  70(3):435-51  PubMed ID: 27178360
6025  Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia.  Abé T, Maruyama S, Yamazaki M, Xu B, Babkair H, Sumita Y, Cheng J, Yamamoto T, Saku T.  Exp Mol Pathol  2017  102(2):327-336  PubMed ID: 28242296
6026  Real-time monitoring system for evaluating the acid-producing activity of oral squamous cell carcinoma cells at different environmental pH.  Morishima H, Washio J, Kitamura J, Shinohara Y, Takahashi T, Takahashi N.  Sci Rep.  2017  7(1):10092  PubMed ID: 28855722
6029  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Ishida S et al  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725
6032  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Tada H, Shimizu T, Nagaoka I, Takada H.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607
6036  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
6042  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332
6043  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471
6044  Adenosine A2b receptor promotes progression of human oral cancer.  Kasama H et al   BMC Cancer  2015  15:563  PubMed ID: 26228921
6051  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  Okamoto A et al  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377
6052  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  Saito T et al  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Miyamoto I et al  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
6054  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Baba T et al  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483
6058  Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor.  Shida-Sakazume T et al  PLoS One.  2015  10(3):e0120143  PubMed ID: 25803864
6056  Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.  Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y.  Anticancer Res  2014  34(8):4117-20  PubMed ID: 25075037
6040  Effects of TiO2 nanoparticles on cytotoxic action of chemotherapeutic drugs against a human oral squamous cell carcinoma cell line.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Ando Y, Kanda Y, Hibino Y, Nakajima H, Sakagami H.  In Vivo  2014  28(2):209-15  PubMed ID: 24632975
6038  Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line  Hiroshi Sakagami et al  Metabolomics  2014  10:270–279 
5916  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  In Vivo  2014  28(4):549-56  PubMed ID: 24982221
5859  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344
5807  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906
5778  Decreased expression of kallikrein-related peptidase 13: possible contribution to metastasis of human oral cancer.  Ishige S, Kasamatsu A, Ogoshi K, Saito Y, Usukura K, Yokoe H, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Mol Carcinog  2014  53(7):557-65  PubMed ID: 23371469
5659  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035
5605  Growth inhibition of head and neck squamous cell carcinoma cells by sgRNA targeting the cyclin D1 mRNA based on TRUE gene silencing.  Iizuka S, Oridate N, Nashimoto M, Fukuda S, Tamura M.  PLoS One  2014  9(12):e114121  PubMed ID: 25437003
5544  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367
5337  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069
5315  Quantitative structure-activity relationship analysis of cytotoxicity and anti-UV activity of 2-aminotropones.  Sekine S, Shimodaira C, Uesawa Y, Kagaya H, Kanda Y, Ishihara M, Amano O, Sakagami H, Wakabayashi H.  Anticancer Res  2014  4(4):1743-50  PubMed ID: 24692705
5190  Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.  Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.  Acta Med Okayama  2013  67(3):153-64  PubMed ID: 23804138
5122  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  Iida S, Shimada J, Sakagami H.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687
5110  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061
5028  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234
6065  Expression of activation-induced cytidine deaminase in oral epithelial dysplasia and oral squamous cell carcinoma.  Miyazaki Y, Fujinami M, Inoue H, Kikuchi K, Ide F, Kusama K.  J Oral Sci  2013  55(4):293-9  PubMed ID: 24351917
6067  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766
6070  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790
6072  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564
6076  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490
6077  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247
6078  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548
6081  Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.  Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  BMC Cancer  2013  13:555  PubMed ID: 24261884
6083  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 4045666
6087  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889
6088  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311
6089  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  J Oral Sci  2012  54(3):241-50  PubMed ID: 2304703
6091  Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.  Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T.  Microbes Infect  2012  14(11):916-21  PubMed ID: 22561467
6095  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894
6098  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Tumour Biol  2012  33(1):183-94  PubMed ID: 2081310
6116  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983
6119  Pili of oral Streptococcus sanguinis bind to fibronectin and contribute to cell adhesion.  Okahashi N, Nakata M, Sakurai A, Terao Y, Hoshino T, Yamaguchi M, Isoda R, Sumitomo T, Nakano K, Kawabata S, Ooshima T.  Biochem Biophys Res Commun  2010  391(2):1192-6  PubMed ID: 20004645
6120  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673
6122  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Nomi N, Kodama S, Suzuki M.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466
6123  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  Yuji Miyazaki et al  J Cancer Sci Ther  2010  2(2) :26-32 
6127  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319
6128  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186
6129  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354
6136  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Okamura M, Shimada J, Sakagami H.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853
6138  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res  2008  28(2A):1069-78 
6140  Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.  Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T.  In Vivo  2008  2(4):471-6  PubMed ID: 18712174
6141  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558
6142  Induction of cell death by combination treatment with cisplatin and 5-fluorouracil in a human oral squamous cell carcinoma cell line.  Okamura M, Kobayashi M, Suzuki F, Shimada J, Sakagami H.  Anticancer Res  2007  27(5A):3331-7  PubMed ID: 17970078
6143  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225
6148  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125
6150  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456
6152  Cytotoxic activity of azulenequinones against human oral tumor cell lines.  Wakabayashi H, Nishishiro M, Arikawa S, Hashimoto K, Kikuchi H, Nishikawa H, Kurihara T, Terakubo S, Shoji Y, Nakashima H, Motohashi N, Sakagami H.  Anticancer Res  2005  25(1A):305-12  PubMed ID: 15816552
11620  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Anticancer Res.  2019    PubMed ID: 31262875
11844  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  Oral Dis  2019    PubMed ID: 31603606
6410  Is parainfluenza virus a threatening virus for human cancer cell lines?  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309



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