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RCB1939 : NUGC-4  update : 2019/10/24
CommentHuman cell line derived from signet ring cell carcinoma of stomach. TKG0449 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0449
Animal human < Mammals
Genus Homo
Species sapiens
Tissue stomach
Case history Signet ring cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0449)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 6
User's Publication 24


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Reference
3128  Takeshima E, Hamaguchi M, Watanabe T, Akiyama S, Kataoka M, Ohnishi Y, Xiao, H Y, Nagai Y, Takagi H  Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.  Jpn J Cancer Res.  1991  82:1428-35  PubMed ID: 1778766
3127  Yoshikawa K, Furukawa K, Ueda R, Iwasa S, Lloyd, K O, Notake K, Takahashi T  A human monoclonal antibody recognizing a surface antigen on stomach cancer cells.  Jpn J Cancer Res (--> Cancer Sci)  1989  80:546-53  PubMed ID: 2474525
3126  Yokoyama I, Watanabe T, Nishikimi M, Ichihashi H, Kondo T, Takagi H, Sakuma S  Radioimmunoscintigraphy of human gastric carcinoma xenografts with 125I-labeled monoclonal antibody.  Jpn J Cancer Res  1986  77:1114-21  PubMed ID: 3098721
3129  Kobayashi M, Nagata S, Iwasaki T, Yanagihara K, Saitoh I, Karouji Y, Ihara S, Fukui Y  Dedifferentiation of adenocarcinomas by activation of phosphatidylinositol 3-kinase.  Proc Natl Acad Sci U S A  1999  96:4874-9  PubMed ID: 10220386
5049  Akiyama S, Amo H, Watanabe T, Matsuyama M, Sakamoto J, Imaizumi M, Ichihashi H, Kondo T, Takagi H.  Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4.  Jpn J Surg  1988  18(4):438-46  PubMed ID: 3172586
5050  Koyama K, Akiyama K, Kawahara H, Egashira A, Murakami H.  Alloimmunization with cultured human stomach cancer cell lines and the establishment of human-human hybridomas producing monoclonal antibodies.  Jpn J Cancer Res  1990  81(10):967-70  PubMed ID: 2121682

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User's Publication
7233  Nakamura S, Kahyo T, Tao H, Shibata K, Kurabe N, Yamada H, Shinmura K, Ohnishi K, Sugimura H.  Novel roles for LIX1L in promoting cancer cell proliferation through ROS1-mediated LIX1L phosphorylation.  Sci Rep  2015  5:13474  PubMed ID: 26310847
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856
8007  Endo S, Yamato K, Hirai S, Moriwaki T, Fukuda K, Suzuki H, Abei M, Nakagawa I, Hyodo I.  Potent in vitro and in vivo antitumor effects of MDM2 inhibitor nutlin-3 in gastric cancer cells.  Cancer Sci.  2011  102:605-13  PubMed ID: 21205074
8320  Tanaka Y, Matsuo K, Yuzuriha S, Yan H, Nakayama J.  Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device.  Cancer Sci.  2010  101:1396-402  PubMed ID: 20345484
8557  Konishi H, Kikuchi S, Ochiai T, Ikoma H, Kubota T, Ichikawa D, Fujiwara H, Okamoto K, Sakakura C, Sonoyama T, Kokuba Y, Sasaki H, Matsui T, Otsuji E.  Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice.  Anticancer Res.  2009  29:2091-7  PubMed ID: 19528469
10082  Jia L, Ren S, Li T, Wu J, Zhou X, Zhang Y, Wu J, Liu W.  Effects of Combined Simultaneous and Sequential Endostar and Cisplatin Treatment in a Mice Model of Gastric Cancer Peritoneal Metastases.  Gastroenterol Res Pract  2017  2017:2920384  PubMed ID: 28197204
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969
10862    Bioequivalence Studies of A Generic Formulation (SW651K) to the Brand Drug S-1 in Tumor-Bearing Rat Models  Journal of Bioequivalence & Bioavailability  2016   
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2018    PubMed ID: 30191346
11246  Kimura R, Yoneshige A, Hagiyama M, Otani T, Inoue T, Shiraishi N, Yanagihara K, Wakayama T, Ito A.  Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: Possible involvement in peritoneal dissemination of signet ring cells.  Life Sci.  2018    PubMed ID: 30312702
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864
4313  Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Ichikawa D, Tsuda H, Otsuji E.  Overexpression of YEATS4 contributes to malignant outcomes in gastric carcinoma.  Am J Cancer Res  2018    PubMed ID: 30662802
5804  Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki  Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26  Oncology Letters  2017  13(1):215-221  PubMed ID: 28123544
5815  Tamura F et al  RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.  Gastric Cancer  2016  19(1):85-97  PubMed ID: 25532910
5827  Ito T, Kajino K, Abe M, Sato K, Maekawa H, Sakurada M, Orita H, Wada R, Kajiyama Y, Hino O.  ERC/mesothelin is expressed in human gastric cancer tissues and cell lines.  Oncol Rep  2014  31(1):27-33  PubMed ID: 24146039
5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286
5833  Sato M, Muguruma N, Nakagawa T, Okamoto K, Kimura T, Kitamura S, Yano H, Sannomiya K, Goji T, Miyamoto H, Okahisa T, Mikasa H, Wada S, Iwata M, Takayama T.  High antitumor activity of pladienolide B and its derivative in gastric cancer.  Cancer Sci  2014  105(1):110-6  PubMed ID: 24635824
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071
5855  Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.  Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.  J Proteome Res  2012  11(12):5736-47  PubMed ID: 23116296
6139  Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y.  IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  Int J Cancer  2008  122(5):1040-6  PubMed ID: 17957782
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309



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