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RCB1904 : MCF7  update : 2018/08/01
CommentHuman cell line derived from breast adenocarcinoma. TKG0479 (Deposited from Tohoku Univ.).
特性(日) ヒト乳腺癌由来細胞株。 TKG0479 (東北大学医用細胞資源センターからの寄託)。
寄託者特性(英)
寄託者特性(日)
使用条件a
使用条件(英)Basically, there is no restriction regarding academic use.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供同意書は、使用機関及び使用内容に応じて二種類あります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は別途ご相談(cellbank.brc@riken.jp)を承ります。
細胞基本情報 寄託者 Obinata, Masuo
樹立者 Soule H.D.
寄託日 2004
元の細胞 TKG0479
動物種 human < Mammals
属名 Homo
種名 sapiens
人種 Caucasian
性別 Female
69 years
採取組織 brest, pleural fluid
病歴 breast adenocarcunima
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0479)
メモ_1 A culture submitted to the CRCBR, Tohoku University was found to be contaminated with mycoplasma. Mycoplasma was eliminated with BM Cycline and MC210 at the CRCBR.
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS + 1mM Sodium Pyruvate + 0.1mM NEAA
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代または培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP, AST
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 0件
Reference(日) 0件
利用者成果(英) 47件
利用者成果(日) 0件

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Fujimoto M, Takii R, Takaki E, Katiyar A, Nakato R, Shirahige K, Nakai A.  The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.  Nat Commun  2017  8:1638  PubMed ID: 29158484
Morizane M, Kawasaki Y, Miura T, Yagi K, Esumi S, Kitamura Y, Sendo T.  Photoinitiator-Initiated Estrogenic Activity in Human Breast Cancer Cell Line MCF-7.  J. Toxicol. Environ. Health Part A  2015  78:1450-60  PubMed ID: 26692070
Nakaoka E, Tanaka S, Onda K, Sugiyama K, Hirano T.  Effects of Vitamin K3 and K5 on Daunorubicin-resistant Human T Lymphoblastoid Leukemia Cells.  Anticancer Res.  2015  35:6041-8  PubMed ID: 26504027
Ninomiya K, Maruyama H, Ogino C, Takahashi K, Shimizu N.  Sonocatalytic injury of cancer cells attached on the surface of a nickel-titanium dioxide alloy plate.  Ultrason Sonochem  2015  28:1-6  PubMed ID: 26384876
Ninomiya K, Yamashita T, Tanabe Y, Imai M, Takahashi K, Shimizu N.  Targeted and ultrasound-triggered cancer cell injury using perfluorocarbon emulsion-loaded liposomes endowed with cancer cell-targeting and fusogenic capabilities.  Ultrason Sonochem  2015  28:54-61  PubMed ID: 26384883
Zhu Q, Bang TH, Ohnuki K, Sawai T, Sawai K, Shimizu K.  Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.  Sci Rep  2015  5:13194  PubMed ID: 26307417
Tomita T, Ieguchi K, Sawamura T, Maru Y.  Human serum amyloid A3 (SAA3) protein, expressed as a fusion protein with SAA2, binds the oxidized low density lipoprotein receptor.  PLoS ONE  2015  10:e0118835  PubMed ID: 25738827
Watari A, Hashegawa M, Muangman T, Yagi K, Kondoh M.  Use of cell-based screening to identify small-molecule compounds that modulate claudin-4 expression.  Biotechnol. Lett.  2015  37:1177-85  PubMed ID: 25700824
Subramanian N, Kanwar JR, Athalya PK, Janakiraman N, Khetan V, Kanwar RK, Eluchuri S, Krishnakumar S.  EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex.  J. Biomed. Sci.  2015  22:4  PubMed ID: 25576037
F Acheampong, C Larbie, FKN Arthur, R Appiah-Opong, I. Tuffour  Antioxidant and anticancer study of Ageratum cornyzoides aqueous extracts.  J Global Biosciences  2015  4:1804-1815 
Masanari Umemura, Mayumi Katsumata, Itaru Sato, Akane Nagasako, Haruki Aoyama, Ayako Makino, Makoto Ohtake, Kayoko Oda, Kosuke Matsuo, Haruki Eguchi, Yoshihiro Ishikawa  Abstract 4398: Methotrexate derivative with intrinsic magnetism.  Cancer Res.  2015  75:4398-4398 
Qin XY, Wei F, Yoshinaga J, Yonemoto J, Tanokura M, Sone H.  siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells.  FEBS Lett.  2011  585:3310-5  PubMed ID: 21945317
Sawajiri M, Nomura Y, Banik S, Nishikiori R, Sonoda Y, Tanimoto K.  Irradiation effect on osteoclastogenesis stimulated by breast cancer cells.  Health Phys  2011  101:259-64  PubMed ID: 21799342
Qin XY, Zaha H, Nagano R, Yoshinaga J, Yonemoto J, Sone H.  Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.  Toxicol. Lett.  2011  206:152-7  PubMed ID: 21771643
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, Inui H.  Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.  Arch. Biochem. Biophys.  2011  509:1-8  PubMed ID: 21338575
Kato A, Endo T, Abiko S, Ariga H, Matsumoto K.  Induction of truncated form of tenascin-X (XB-S) through dissociation of HDAC1 from SP-1/HDAC1 complex in response to hypoxic conditions.  Exp. Cell Res.  2008  314:2661-73  PubMed ID: 18588874
Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153
Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M.  Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.  Nat Commun  2018  9:1561  PubMed ID: 29674746
Sasaki S, Kanzaki M, Kaneko T.  Calcium influx through TRP channels induced by short-lived reactive species in plasma-irradiated solution.  Sci Rep  2016  6:25728  PubMed ID: 27169489
Kanzaki H, Shinohara F, Suzuki M, Wada S, Miyamoto Y, Yamaguchi Y, Katsumata Y, Makihira S, Kawai T, Taubman MA, Nakamura Y.  A-Disintegrin and Metalloproteinase (ADAM) 17 Enzymatically Degrades Interferon-gamma.  Sci Rep  2016  6:32259  PubMed ID: 27573075
Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M.  Deficiency of X-Linked Protein Kinase Nrk during Pregnancy Triggers Breast Tumor in Mice.  Am. J. Pathol.  2016  186:2751-60  PubMed ID: 27634343
Tanaka S, Sakaguchi M, Yoneyama H, Usami Y, Harusawa S.  Histamine H3 receptor antagonist OUP-186 attenuates the proliferation of cultured human breast cancer cell lines.  Biochem. Biophys. Res. Commun.  2016  480:479-485  PubMed ID: 27773822
Poulose AC, Veeranarayanan S, Mohamed MS, Aburto RR, Mitcham T, Bouchard RR, Ajayan PM, Sakamoto Y, Maekawa T, Kumar DS.  Multifunctional Cu2-xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453.  Sci Rep  2016  6:35961  PubMed ID: 27775048
Fujimoto M, Inoue T, Kito H, Niwa S, Suzuki T, Muraki K, Ohya S.  Transcriptional repression of HER2 by ANO1 Cl- channel inhibition in human breast cancer cells with resistance to trastuzumab.  Biochem. Biophys. Res. Commun.  2017  482:188-194  PubMed ID: 27838298
Khatun A, Fujimoto M, Kito H, Niwa S, Suzuki T, Ohya S.  Down-Regulation of Ca2+-Activated K⁺ Channel KCa1.1 in Human Breast Cancer MDA-MB-453 Cells Treated with Vitamin D Receptor Agonists.  Int J Mol Sci  2016  17:  PubMed ID: 27973439
Matsumura K, Nakata S, Taniguchi K, Ii H, Ashihara E, Kageyama S, Kawauchi A, Yoshiki T.  Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation.  BMC Cancer  2016  16:748  PubMed ID: 27658708
Tanaka S, Suzuki K, Sakaguchi M.  The prolyl oligopeptidase inhibitor SUAM-14746 attenuates the proliferation of human breast cancer cell lines in vitro.  Breast Cancer  2017  24:658-666  PubMed ID: 28070831
Tatebe H, Murayama S, Yonekura T, Hatano T, Richter D, Furuya T, Kataoka S, Furuita K, Kojima C, Shiozaki K.  Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit.  Elife  2017  6:  PubMed ID: 28264193
Kitajima S, Yoshida A, Kohno S, Li F, Suzuki S, Nagatani N, Nishimoto Y, Sasaki N, Muranaka H, Wan Y, Thai TC, Okahashi N, Matsuda F, Shimizu H, Nishiuchi T, Suzuki Y, Tominaga K, Gotoh N, Suzuki M, Ewen ME, Barbie DA, Hirose O, Tanaka T, Takahashi C.  The RB-IL-6 axis controls self-renewal and endocrine therapy resistance by fine-tuning mitochondrial activity.  Oncogene  2017  36:5145-5157  PubMed ID: 28481867
Nashimoto Y, Hayashi T, Kunita I, Nakamasu A, Torisawa YS, Nakayama M, Takigawa-Imamura H, Kotera H, Nishiyama K, Miura T, Yokokawa R.  Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device.  Integr Biol (Camb)  2017  9:506-518  PubMed ID: 28561127
Yao M, Yuan B, Wang X, Sato A, Sakuma K, Kaneko K, Komuro H, Okazaki A, Hayashi H, Toyoda H, Pei X, Hu X, Hirano T, Takagi N.  Synergistic cytotoxic effects of arsenite and tetrandrine in human breast cancer cell line MCF-7.  Int. J. Oncol.  2017  51:587-598  PubMed ID: 28656245
Wakahara M, Sakabe T, Kubouchi Y, Hosoya K, Hirooka Y, Yurugi Y, Nosaka K, Shiomi T, Nakamura H, Umekita Y.  Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer.  Anticancer Res.  2017  37:5071-5077  PubMed ID: 28870936
Kawabata H, Azuma K, Ikeda K, Sugitani I, Kinowaki K, Fujii T, Osaki A, Saeki T, Horie-Inoue K, Inoue S.  TRIM44 Is a Poor Prognostic Factor for Breast Cancer Patients as a Modulator of NF-κB Signaling.  Int J Mol Sci  2017  18:  PubMed ID: 28885545
Mellini P, Itoh Y, Tsumoto H, Li Y, Suzuki M, Tokuda N, Kakizawa T, Miura Y, Takeuchi J, Lahtela-Kakkonen M, Suzuki T.  Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.  Chem Sci  2017  8:6400-6408  PubMed ID: 28989670
Gallagher EJ, Henneman PL, Schropp MA.  Derivation and validation of a methodology for tracking academic stature of medical schools. Task Force on the Development of Emergency Medicine.  Acad Emerg Med  1997  4:742-5  PubMed ID: 9223702
Taniguchi K, Matsumura K, Kageyama S, Ii H, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S.  Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase.  Biochem. Biophys. Res. Commun.  2018  496:218-224  PubMed ID: 29307834
Bao H, Bai T, Takata K, Yokobori T, Ohnaga T, Hisada T, Maeno T, Bao P, Yoshida T, Kumakura Y, Honjo H, Sakai M, Sohda M, Fukuchi M, Altan B, Handa T, Ide M, Miyazaki T, Ogata K, Oyama T, Shimizu K, Mogi A, Asao T, Shirabe K, Kuwano H, Kaira K.  High expression of carcinoembryonic antigen and telomerase reverse transcriptase in circulating tumor cells is associated with poor clinical response to the immune checkpoint inhibitor nivolumab.  Oncol Lett  2018  15:3061-3067  PubMed ID: 29435038
Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N.  Identification of a small-molecule ligand of β-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells.  Cancer Med  2018  7:883-893  PubMed ID: 29380537
Oo PS, Yamaguchi Y, Sawaguchi A, Tin Htwe Kyaw M, Choijookhuu N, Noor Ali M, Srisowanna N, Hino SI, Hishikawa Y.  Estrogen Regulates Mitochondrial Morphology through Phosphorylation of Dynamin-related Protein 1 in MCF7 Human Breast Cancer Cells.  Acta Histochem Cytochem  2018  51:21-31  PubMed ID: 29622847
Xie P, Horio F, Fujii I, Zhao J, Shinohara M, Matsukura M.  A novel polysaccharide derived from algae extract inhibits cancer progression via JNK, not via the p38 MAPK signaling pathway.  Int. J. Oncol.  2018    PubMed ID: 29512724
Taniguchi K, Matsumura K, Ii H, Kageyama S, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S.  Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence.  Am J Cancer Res  2018  8:650-661  PubMed ID: 29736310
  Targeting CD44, ABCG2 and CD133 markers using aptamers: in silico analysis of CD133 extracellular domain 2 and its aptamer        PubMed ID:
  Development of an ‘OFF-ON-OFF’ fluorescent pH sensor suitable for the study of intracellular pH        PubMed ID:
  Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines        PubMed ID:
  Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines        PubMed ID:
  Engineering a three-dimensional tissue model with a perfusable vasculature in a microfluidic device        PubMed ID:
  METHOD FOR INDUCING CELL REPROGRAMMING, AND METHOD FOR PRODUCING PLURIPOTENT CELLS        PubMed ID:

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