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Cell No. : Cell Name
RCB1903 : OVK18  update : 2023/01/05
CommentHuman cell line derived from ovarial cancer, subclone of RCB2535. TKG0323 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Uehara, S.
Year of deposit 2004
Original cell TKG0323
Animal _human < Mammals
Genus Homo
Species sapiens
Tissue ovary, ascites meta
Disease name ovarial carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0323)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3770
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium MEM + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 20


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Reference
5033  Uehara S, Abe H, Hoshiai H, Yajima A, Suzuki M.  Establishment and characterization of ovarian endometrioid carcinoma cell line.  Gynecol Oncol  1984  17(3):314-25  PubMed ID: 6584390   DOI: 10.1016/0090-8258(84)90217-8

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User's Publication
21200  Takahashi R, Kamizaki K, Yamanaka K, Terai Y, Minami Y.  Expression of Ferredoxin1 in cisplatin‑resistant ovarian cancer cells confers their resistance against ferroptosis induced by cisplatin.  Oncol Rep  2023  49(6)  PubMed ID: 37144519   DOI: 10.3892/or.2023.8561
20010  Shorstova T, Su J, Zhao T, Dahabieh M, Leibovitch M, De Sa Tavares Russo M, Avizonis D, Rajkumar S, Watson IR, Del Rincón SV, Miller WH Jr, Foulkes WD, Witcher M.  Reprogramming of Nucleotide Metabolism Mediates Synergy between Epigenetic Therapy and MAP Kinase Inhibition.  Mol Cancer Ther  2021  20(1):64-75  PubMed ID: 33087508   DOI: 10.1158/1535-7163.MCT-20-0259
16728  YUSUF LIMBONGAN, RICO RAMADHAN, KUNIYOSHI SHIMIZU, Enos Tangkearung  Agronomic characteristics of 30 promising lines of aromatic, red, and black rice and their antioxidant and cytotoxic effects in some cancer cells  Biodiversitas Journal of Biological Diversity  2021      DOI: 10.13057/biodiv/d220412
12103  Adachi M, Masugi Y, Yamazaki K, Emoto K, Kobayashi Y, Tominaga E, Banno K, Aoki D, Sakamoto M.  Upregulation of cyclase-associated actin cytoskeleton regulatory protein 2 in epithelial ovarian cancer correlates with aggressive histologic types and worse outcomes.  Jpn. J. Clin. Oncol.  2020    PubMed ID: 32211793   DOI: 10.1093/jjco/hyaa026
12104  Guan L, Li Z, Xie F, Pang Y, Zhang C, Tang H, Zhang H, Chen C, Zhan Y, Zhao T, Jiang H, Jia X, Wang Y, Lu Y.  Oncogenic and drug-sensitive RET mutations in human epithelial ovarian cancer.  J. Exp. Clin. Cancer Res.  2020    PubMed ID: 32293499   DOI: 10.1186/s13046-020-01557-3
13109  De Haven Brandon A, Box G, Hallsworth A, Court W, Matthews N, Herodek B, Arteagabeitia AB, Valenti M, Kirkin V.  Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice.  Sci Rep  2020    PubMed ID: 32612269   DOI: 10.1038/s41598-020-67533-1
13385  Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ.  Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.  Cell Rep  2020    PubMed ID: 33326793   DOI: 10.1016/j.celrep.2020.108493
11511  Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ.  Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.  Nature  2019    PubMed ID: 30971826   DOI: 10.1038/s41586-019-1103-9
12548  Shorstova T, Marques M, Su J, Johnston J, Kleinman CL, Hamel N, Huang S, Alaoui-Jamali MA, Foulkes WD, Witcher M.  SWI/SNF-Compromised Cancers Are Susceptible to Bromodomain Inhibitors  Cancer Res  2019  79(10):2761-2774  PubMed ID: 30877105   DOI: 10.1158/0008-5472.CAN-18-1545
14274  Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ.  WRN helicase is a synthetic lethal target in microsatellite unstable cancers  Nature  2019  568(7753):551-556  PubMed ID: 30971823   DOI: 10.1038/s41586-019-1102-x
11196  De P, Carlson JH, Leyland-Jones B, Williams C, Dey N.  Triple Fluorescence staining to Evaluate Mechanism-based Apoptosis following Chemotherapeutic and Targeted Anti-cancer Drugs in Live Tumor Cells.  Sci Rep  2018  8(1):13192  PubMed ID: 30181562   DOI: 10.1038/s41598-018-31575-3
10443  Umemura M, Kim JH, Aoyama H, Hoshino Y, Fukumura H, Nakakaji R, Sato I, Ohtake M, Akimoto T, Narikawa M, Tanaka R, Fujita T, Yokoyama U, Taguri M, Okumura S, Sato M, Eguchi H, Ishikawa Y.  The iron chelating agent, deferoxamine detoxifies Fe(Salen)-induced cytotoxicity.  J. Pharmacol. Sci.  2017  134:203-210  PubMed ID: 28779994   DOI: 10.1016/j.jphs.2017.07.002
4547  Takasugi M, Okada R, Takahashi A, Virya Chen D, Watanabe S, Hara E.  Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.  Nat Commun  2017  8:15729  PubMed ID: 28585531   DOI: 10.1038/ncomms15728
9659  Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Sarah K Knutson, Kristy Kuplast-Barr, Maria Roche, John Campbell, Peter Ho, Robert A Copeland, Richard Chesworth, Jesse J Smith, Heike Keilhack, Scott A Ribich  Selective Killing of SMARCA2- And SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models  Mol Cancer Ther   2017  16(5):850-860  PubMed ID: 28292935   DOI: 10.1158/1535-7163.MCT-16-0678
9731  Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O.  Establishment of anti-mesothelioma monoclonal antibodies.  BMC Res Notes  2016  9:324  PubMed ID: 27342200   DOI: 10.1186/s13104-016-2128-x
9622  Xu-Li Wang, Kang-Ping Xu, Hong-Ping Long, Hui Zou, Xiao-Zheng Cao, Kai Zhang, Jian-Zhong Hu, Shu-Jin He, Gang-Zhi Zhu, Xiao-Ai He, Ping-Sheng Xu, Gui-Shan Tan   New Isoindolinones From the Fruiting Bodies of Hericium Erinaceum  Fitoterapia  2016  111:58-65  PubMed ID: 27094113   DOI: 10.1016/j.fitote.2016.04.010
12905  Yagi H, Asanoma K, Ohgami T, Ichinoe A, Sonoda K, Kato K.  GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer  Oncogene  2016  35(34):4471-80  PubMed ID: 26804165   DOI: 10.1038/onc.2015.505
7449  Wada S, Kubota Y, Sawa R, Umekita M, Hatano M, Ohba S, Hayashi C, Igarashi M, Nomoto A.  Novel autophagy inducers lentztrehaloses A, B and C.  J. Antibiot.  2015  68:521-9  PubMed ID: 25757606   DOI: 10.1038/ja.2015.23
15130  Asanuma D, Sakabe M, Kamiya M, Yamamoto K, Hiratake J, Ogawa M, Kosaka N, Choyke PL, Nagano T, Kobayashi H, Urano Y.  Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo  Nat Commun  2015  6:6463  PubMed ID: 25765713   DOI: 10.1038/ncomms7463
5012  Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.  Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.  Hum Mol Genet  2006  15(6):821-30  PubMed ID: 16439445   DOI: 10.1093/hmg/ddl001



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