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細胞番号 : 細胞名
RCB1902 : HSC-4  update : 2023/01/05
細胞特性(Comment:英)Human tongue squamous cell carcinoma derived cell line. TKG0489 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト舌癌由来細胞株。 TKG0489 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
寄託日 2004
元の細胞 TKG0489
動物種 _human < Mammals
属名 Homo
種名 sapiens
採取組織 tongue
病名 Squamous cell carcinoma
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0489)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_1289
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 4件
Reference(日) 0件
利用者成果(英) 194件
利用者成果(日) 2件

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Reference(英)
3303  Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S.  Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.  In Vitro Cell Dev Biol  1990  26:849-856  PubMed ID: 2228902   DOI: 10.1007/BF02624609
3089  Miyazaki K, Takaku H, Umeda M, Fujita T, Huang WD, Kimura T, Yamashita J, Horio T  Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line.  Cancer Res  1990  50:4522-7  PubMed ID: 2164440  
3248  Ichijo H, Momose F, Miyazono K  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718   DOI: 10.1016/0014-4827(90)90090-w
3243  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303   DOI: 10.1111/j.1600-0714.1989.tb01570.x

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Reference(日)

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利用者成果(英)
21577  Al Awadh AA, Sakagami H, Amano S, Sayed AM, Abouelela ME, Alhasaniah AH, Aldabaan N, Refaey MS, Abdelhamid RA, Khalil HMA, Hamdan DI, Abdel-Sattar ES, Orabi MAA.  In vitro cytotoxicity of Withania somnifera (L.) roots and fruits on oral squamous cell carcinoma cell lines: a study supported by flow cytometry, spectral, and computational investigations.  Front Pharmacol  2024  15:1325272  PubMed ID: 38303989   DOI: 10.3389/fphar.2024.1325272
21608  Sakai R, Fujiwara K, Nagasaki-Maeoka E, Inagaki Y, Yamaoka B, Muto-Fujita E, Kamidaki Y, Koshinaga T, Uehara S, Takayama T, Sato S.  Knockdown of TFAP2E results in rapid G2/M transition in oral squamous cell carcinoma cells.  Oncol Lett  2024  27(3):128  PubMed ID: 38333638   DOI: 10.3892/ol.2024.14260
19875  Abe T, Sakagami H, Amano S, Uota S, Bandow K, Uesawa Y, U S, Shibata H, Takemura Y, Kimura Y, Takao K, Sugita Y, Sato A, Tanuma SI, Takeshima H.  A Comparative Study of Tumor-Specificity and Neurotoxicity between 3-Styrylchromones and Anti-Cancer Drugs  Medicines (Basel)  2023  10(7):43  PubMed ID: 37505064   DOI: 10.3390/medicines10070043
21082  Bessho T, Takagi T, Igawa K, Sato K.  Gelatin-based cell culture device for construction and X-ray irradiation of a three-dimensional oral cancer model.  Anal Sci  2023    PubMed ID: 36848001   DOI: 10.1007/s44211-023-00308-6
21380  Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I.  Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia.  Anticancer Res  2023  43(8):3429-3439  PubMed ID: 37500171   DOI: 10.21873/anticanres.16518
21527  Orabi MAA, Orabi EA, Awadh AAA, Alshahrani MM, Abdel-Wahab BA, Sakagami H, Hatano T.  New Megastigmane and Polyphenolic Components of Henna Leaves and Their Tumor-Specific Cytotoxicity on Human Oral Squamous Carcinoma Cell Lines.  Antioxidants (Basel)  2023  12(11)  PubMed ID: 38001804   DOI: 10.3390/antiox12111951
20382  Fan M, Arai M, Tawada A, Chiba T, Fukushima R, Uzawa K, Shiiba M, Kato N, Tanzawa H, Takiguchi Y.  Contrasting functions of the epithelial‑stromal interaction 1 gene, in human oral and lung squamous cell cancers.  Oncol Rep  2022  47(1)  PubMed ID: 34738627   DOI: 10.3892/or.2021.8216
20513  Kono M, Komatsuda H, Yamaki H, Kumai T, Hayashi R, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Kobayashi H, Harabuchi Y.  Immunomodulation via FGFR inhibition augments FGFR1 targeting T-cell based antitumor immunotherapy for head and neck squamous cell carcinoma.  Oncoimmunology  2022  11(1):2021619  PubMed ID: 35003900   DOI: 10.1080/2162402X.2021.2021619
20544  Matsuda R, Sakagami H, Amano S, Iijima Y, Sano M, Uesawa Y, Tamura N, Oishi Y, Takeshima H.  Inhibition of Neurotoxicity/Anticancer Activity of Bortezomib by Caffeic Acid and Chlorogenic Acid.  Anticancer Res  2022  42(2):781-790  PubMed ID: 35093876   DOI: 10.21873/anticanres.15536
20551  Kono M, Yamaki H, Komatsuda H, Kumai T, Hayashi R, Wakisaka R, Sato R, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Harabuchi Y.  IL-2 complex recovers steroid-induced inhibition in immunochemotherapy for head and neck cancer.  Transl Oncol  2022  18:101358  PubMed ID: 35123188   DOI: 10.1016/j.tranon.2022.101358
20559  Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis.  Oncol Lett  2022  23(2):49  PubMed ID: 34992682   DOI: 10.3892/ol.2021.13167
16203  Sasabe E, Tomomura A, Liu H, Sento S, Kitamura N, Yamamoto T.  Epidermal growth factor/epidermal growth factor receptor signaling blockage inhibits tumor cell-derived exosome uptake by oral squamous cell carcinoma through macropinocytosis  Cancer Sci   2022  113(2):609-621  PubMed ID: 34874595   DOI: 10.1111/cas.15225
20648  Naitoh K, Orihara Y, Sakagami H, Miura T, Satoh K, Amano S, Bandow K, Iijima Y, Kurosaki K, Uesawa Y, Hashimoto M, Wakabayashi H.  Tumor-Specificity, Neurotoxicity, and Possible Involvement of the Nuclear Receptor Response Pathway of 4,6,8-Trimethyl Azulene Amide Derivatives.  Int J Mol Sci  2022  23(5)  PubMed ID: 35269748   DOI: 10.3390/ijms23052601
20815  Hossain M, Roayapalley PK, Sakagami H, Satoh K, Bandow K, Das U, Dimmock JR.  Dichloroacetyl Amides of 3,5-Bis(benzylidene)-4-piperidones Displaying Greater Toxicity to Neoplasms than to Non-Malignant Cells.  Medicines (Basel)  2022  9(6)  PubMed ID: 35736248   DOI: 10.3390/medicines9060035
20838  Kobayashi M, Fujiwara K, Takahashi K, Yoshioka Y, Ochiya T, Podyma-Inoue KA, Watabe T.  Transforming growth factor-β-induced secretion of extracellular vesicles from oral cancer cells evokes endothelial barrier instability via endothelial-mesenchymal transition.  Inflamm Regen  2022  42(1):38  PubMed ID: 36057626   DOI: 10.1186/s41232-022-00225-7
20870  Takahashi K, Podyma-Inoue KA, Saito M, Sakakitani S, Sugauchi A, Iida K, Iwabuchi S, Koinuma D, Kurioka K, Konishi T, Tanaka S, Kaida A, Miura M, Hashimoto S, Okada M, Uchihashi T, Miyazono K, Watabe T.  TGF-β generates a population of cancer cells residing in G1 phase with high motility and metastatic potential via KRTAP2-3.  Cell Rep  2022  40(13):111411  PubMed ID: 36170816   DOI: 10.1016/j.celrep.2022.111411
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20960  Zhang X, Han Y, Liu S, Guo B, Xu S, He Y, Liu L.  MF-094 nanodelivery inhibits oral squamous cell carcinoma by targeting USP30.  Cell Mol Biol Lett  2022  27(1):107  PubMed ID: 36474192   DOI: 10.1186/s11658-022-00407-8
20965  Morisaka H, Takaishi M, Akira S, Sano S.  Keratinocyte Regnase-1, a down-regulator of skin inflammation, contributes to protection against tumor promotion by limiting COX-2 expression.  J Invest Dermatol  2022    PubMed ID: 36470473   DOI: 10.1016/j.jid.2022.11.007
13361  Luo F, Sugita H, Muraki K, Saeki S, Chaipech S, Pongpiriyadacha Y, Muraoka O, Morikawa T.  Anti-proliferative activities of coumarins from the Thai medicinal plant Mammea siamensis (Miq.) T. Anders. against human digestive tract carcinoma cell lines.  Fitoterapia  2021    PubMed ID: 33246033   DOI: 10.1016/j.fitote.2020.104780
13462  Sawa Y, Ibaragi S, Okui T, Yamashita J, Ikebe T, Harada H.  Expression of SARS-CoV-2 entry factors in human oral tissue  J Anat  2021  Jan 9  PubMed ID: 33421967   DOI: 10.1111/joa.13391
20059  Kiguchi T, Kakihara Y, Yamazaki M, Katsura K, Izumi K, Tanuma JI, Saku T, Takagi R, Saeki M.  Identification and characterization of R2TP in the development of oral squamous cell carcinoma.  Biochem Biophys Res Commun  2021  548: 161-166  PubMed ID: 33640610   DOI: 10.1016/j.bbrc.2021.02.074
20085  Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H.  Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.  Sci Rep  2021  11(1):5897  PubMed ID: 33723306   DOI: 10.1038/s41598-021-85242-1
20133  Nakamura A, Kakihara Y, Funayama A, Haga K, Mikami T, Kobayashi D, Yoshida Y, Izumi K, Kobayashi T, Saeki M.  HEATR1, a novel interactor of Pontin/Reptin, stabilizes Pontin/Reptin and promotes cell proliferation of oral squamous cell carcinoma.  Biochem Biophys Res Commun  2021  557:294-301  PubMed ID: 33894417   DOI: 10.1016/j.bbrc.2021.04.021
14341  Kono M, Kumai T, Hayashi R, Yamaki H, Komatsuda H, Wakisaka R, Nagato T, Ohkuri T, Kosaka A, Ohara K, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Kobayashi H, Harabuchi Y.  Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery  Cancer Immunol Immunother  2021    PubMed ID: 33866408   DOI: 10.1007/s00262-021-02940-5
20350  Haga K, Yamazaki M, Maruyama S, Kawaharada M, Suzuki A, Hoshikawa E, Chan NN, Funayama A, Mikami T, Kobayashi T, Izumi K, Tanuma JI.  Crosstalk between oral squamous cell carcinoma cells and cancer-associated fibroblasts via the TGF-β/SOX9 axis in cancer progression.  Transl Oncol  2021  14(12):101236  PubMed ID: 34624685   DOI: 10.1016/j.tranon.2021.101236
15868  Itashiki Y, Harada K, Takenawa T, Ferdous T, Ueyama Y, Mishima K.  Antitumor effects of bevacizumab in combination with fluoropyrimidine drugs on human oral squamous cell carcinoma  Oncol Lett  2021  22(4):730  PubMed ID: 34429770   DOI: 10.3892/ol.2021.12991
20455  Harada K, Ferdous T, Mishima K.  Efficacy of a Novel Oral Chemotherapeutic Agent, TAS-102, Against Human Oral Squamous Cell Carcinoma Cells.  Anticancer Res  2021  41(12):6039-6049  PubMed ID: 34848458   DOI: 10.21873/anticanres.15423
16136  Harada K, Ferdous T, Watanabe K, Mizukami Y, Mishima K.  Effects of an elemental diet, Elental®, may differ between healthy oral cells and oral cancer cells  Oncol Rep  2021  45(2):738-751  PubMed ID: 33416174   DOI: 10.3892/or.2020.7896
16174  Roayapalley PK, Dimmock JR, Contreras L, Balderrama KS, Aguilera RJ, Sakagami H, Amano S, Sharma RK, Das U.  Design, Synthesis and Tumour-Selective Toxicity of Novel 1-[3-{3,5-Bis(benzylidene)-4-oxo-1-piperidino}-3-oxopropyl]-4-piperidone Oximes and Related Quaternary Ammonium Salts  Molecules  2021  26(23):7132  PubMed ID: 34885719   DOI: 10.3390/molecules26237132
16196  Sakagami H, Furukawa T, Satoh K, Amano S, Iijima Y, Koshikawa T, Asai D, Fukuchi K, Takemura H, Kanamoto T, Yokose S.  Re-Evaluation of Chemotherapeutic Potential of Pyoktanin Blue  Medicines (Basel)  2021  8(7):33  PubMed ID: 34206186   DOI: 10.3390/medicines8070033
16200  Roayapalley PK, Sakagami H, Satoh K, Amano S, Bandow K, Aguilera RJ, Hernandez KGC, Schiaffino Bustamante AY, Dimmock SG, Sharma RK, Das U, Dimmock JR.  Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring  Medicines (Basel)  2021  8(12):78  PubMed ID: 34940290   DOI: 10.3390/medicines8120078
16206  Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N.  Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma  Int J Mol Sci  2021  22(18):9947  PubMed ID: 34576110   DOI: 10.3390/ijms22189947
16211  Shyla Gopalakrishnan, Soumya Krishnan Uma, Gayathri Mohan, Amrutha Mohan, Geetha Shanmugam, Vineeth T. V. Kumar, Sreekumar J, Sivakumar K. Chandrika, Dileep Vasudevan, Sai Ravi Chandra Nori, Shijulal Nelson Sathi, Sanil George, Tessy Thomas Maliekal  SSTP1, a Host Defense Peptide, Exploits the Immunomodulatory IL6 Pathway to Induce Apoptosis in Cancer Cells  Front Immunol  2021  12:740620  PubMed ID: 34867962   DOI: 10.3389/fimmu.2021.740620
16862  Kawasaki M, Sakabe T, Kodani I, Umekita Y.  Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma  Anticancer Res  2021  41(9):4563-4570  PubMed ID: 34475084   DOI: 10.21873/anticanres.15269
16975  Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K.  Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling  Anticancer Res  2021  41(4):1821-1830  PubMed ID: 33813387   DOI: 10.21873/anticanres.14948
11844  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Oral Dis  2020  26(4):745-755  PubMed ID: 31603606   DOI: 10.1111/odi.13210
11965  Fujii S, Tajiri Y, Hasegawa K, Matsumoto S, Yoshimoto RU, Wada H, Kishida S, Kido MA, Yoshikawa H, Ozeki S, Kiyoshima T.  The TRPV4-AKT axis promotes oral squamous cell carcinoma cell proliferation via CaMKII activation.  Lab. Invest.  2020    PubMed ID: 31857698   DOI: 10.1038/s41374-019-0357-z
12166  Yuichi Ohnishi Tsukasa Sakamoto Li Zhengguang Hiroki Yasui Hiroyuki Hamada Hirohito Kubo Masahiro Nakajima  Curcumin inhibits epithelial‑mesenchymal transition in oral cancer cells via c‑Met blockade  Oncology Letter  2020    PubMed ID: 32391111   DOI: 10.3892/ol.2020.11523
13013  Nakaya G, Sakagami H, Koga-Ogawa Y, Shiroto A, Nobesawa T, Ueda D, Nakatani S, Kobata K, Iijima Y, Tone S, David-Gonzalez A, Garcia-Contreras R, Tomomura M, Kito S, Tamura N, Takeshima H.  Augmentation of Neurotoxicity of Anticancer Drugs by X-Ray Irradiation.  In Vivo  2020    PubMed ID: 32354886   DOI: 10.21873/invivo.11869
13093  Iijima Y, Bandow K, Amano S, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  Protection of Bortezomib-induced Neurotoxicity by Antioxidants.  Anticancer Res  2020    PubMed ID: 32620607   DOI: 10.21873/anticanres.14357
13205  Teratani M, Nakamura S, Sakagami H, Fujise M, Hashimoto M, Okudaira N, Bandow K, Iijima Y, Nagai J, Uesawa Y, Wakabayashi H.  Antitumor Effects and Tumor-specificity of Guaiazulene-3-Carboxylate Derivatives Against Oral Squamous Cell Carcinoma In Vitro.  Anticancer Res  2020    PubMed ID: 32878776   DOI: 10.21873/anticanres.14491
13401  Hayashi R, Nagato T, Kumai T, Ohara K, Ohara M, Ohkuri T, Hirata-Nozaki Y, Harabuchi S, Kosaka A, Nagata M, Yajima Y, Yasuda S, Oikawa K, Kono M, Kishibe K, Takahara M, Katada A, Hayashi T, Celis E, Harabuchi Y, Kobayashi H.  Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma.  Oncoimmunology  2020    PubMed ID: 33457076   DOI: 10.1080/2162402X.2020.1856545
13524  Yoshimatsu Y, Wakabayashi I, Kimuro S, Takahashi N, Takahashi K, Kobayashi M, Maishi N, Podyma-Inoue KA, Hida K, Miyazono K, Watabe T.  TNF-α enhances TGF-β-induced endothelial-to-mesenchymal transition via TGF-β signal augmentation  Cancer Sci  2020  111(7):2385-2399  PubMed ID: 32385953   DOI: 10.1111/cas.14455
13783  Otsuki Y, Yamasaki J, Suina K, Okazaki S, Koike N, Saya H, Nagano O.  Vasodilator oxyfedrine inhibits aldehyde metabolism and thereby sensitizes cancer cells to xCT-targeted therapy  Cancer Sci  2020  111(1):127-136.  PubMed ID: 31692172   DOI: 10.1111/cas.14224
13903  Aika Tanzawa et al.  Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma  Oral Science International  2020  17(2):67-72    DOI: 10.1002/osi2.1044
11354  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341   DOI: 10.1016/j.bbrc.2018.12.066
11620  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Anticancer Res.  2019    PubMed ID: 31262875   DOI: 10.21873/anticanres.13497
9696  Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa  Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma  Exp Cell Res  2019  384(2):111622  PubMed ID: 31518558   DOI: 10.1016/j.yexcr.2019.111622
9726  Mohamed A A Orabi, Esam A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Yoshiaki Amakura, Tsutomu Hatano   Structures, NMR Spectroscopic Features, and Cytotoxic Properties of Oligomeric Hellinoyl ( m-GO- m-GOG)-Type Ellagitannins From the Galls of Tamarix aphylla  J Nat Prod  2019  82(10):2682-2695  PubMed ID: 31532650   DOI: 10.1021/acs.jnatprod.9b00073
9890  Noritoshi Oka, Atsushi Kasamatsu, Yosuke Endo-Sakamoto, Keitaro Eizuka, Sho Wagai, Nao Koide-Ishida, Isao Miyamoto, Manabu Iyoda, Hideki Tanzawa, Katsuhiro Uzawa  Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement  J Cancer  2019  10(16):3728-3734  PubMed ID: 31333790   DOI: 10.7150/jca.32281
10427  Siti Aisyah Abd Ghafar, Ira Hazwani Hasan Fikri, Zolkapli Eshak  Antioxidant Activity of Musa Paradisiaca(Banana) Soft Pith and Its Cytotoxicity Against Oral Squamous Carcinoma Cell Lines  MJoSHT  2019  3(1):8-11   
11907  Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M.  Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review.  Dis. Markers  2019    PubMed ID: 31019584   DOI: 10.1155/2019/8040361
11931  Iijima Y, Bandow K, Sano M, Hino S, Kaneko T, Horie N, Sakagami H.  In Vitro Assessment of Antitumor Potential and Combination Effect of Classical and Molecular-targeted Anticancer Drugs.  Anticancer Res.  2019    PubMed ID: 31810932   DOI: 10.21873/anticanres.13882
11933  Nagai J, Shi H, Sezaki N, Yoshida N, Bandow K, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-Arylazolylchromones and 2-Triazolylchromones.  Anticancer Res.  2019    PubMed ID: 31810912   DOI: 10.21873/anticanres.13862
12457  Eizuka K, Nakashima D, Oka N, Wagai S, Takahara T, Saito T, Koike K, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K.  SYT12 plays a critical role in oral cancer and may be a novel therapeutic target  J Cancer  2019  10(20):4913-4920  PubMed ID: 31598163   DOI: 10.7150/jca.32582
12458  Okazaki S, Umene K, Yamasaki J, Suina K, Otsuki Y, Yoshikawa M, Minami Y, Masuko T, Kawaguchi S, Nakayama H, Banno K, Aoki D, Saya H, Nagano O.  Glutaminolysis-related genes determine sensitivity to xCT-targeted therapy in head and neck squamous cell carcinoma  Cancer Sci  2019  110(11):3453-3463  PubMed ID: 31444923   DOI: 10.1111/cas.14182
12459  Krishnan NM, Katoh H, Palve V, Pareek M, Sato R, Ishikawa S, Panda B.  Functional genomics screen with pooled shRNA library and gene expression profiling with extracts of Azadirachta indica identify potential pathways for therapeutic targets in head and neck squamous cell carcinoma  PeerJ  2019  7:e6464  PubMed ID: 30842898   DOI: 10.7717/peerj.6464
12460  Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H.  LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer  Oncotarget  2019  10(10):1014-1030  PubMed ID: 30800215   DOI: 10.18632/oncotarget.26583
12586  Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S.  Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner  J Clin Biochem Nutr  2019  65(1):8-15  PubMed ID: 31379408   DOI: 10.3164/jcbn.18-91
10664  Ohnishi Y, Yasui H, Nozaki M, Nakajima M.  Molecularly-targeted therapy for the oral cancer stem cells.  Jpn Dent Sci Rev  2018  54:88-103  PubMed ID: 29755619   DOI: 10.1016/j.jdsr.2017.11.001
10682  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705   DOI: 10.1016/j.bbrc.2017.12.138
10724  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707   DOI: 10.21873/anticanres.12289
10806  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312   DOI: 10.1016/j.yexcr.2018.03.041
10829  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  In Vivo  2018  32:479-486  PubMed ID: 29695549   DOI: 10.21873/invivo.11264
11086  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675   DOI: 10.21873/anticanres.12593
11110  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454   DOI: 10.21873/invivo.11303
11115  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510   DOI: 10.21873/anticanres.12674
11148  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210   DOI: 10.21873/anticanres.12748
11226  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  J Cancer  2018    PubMed ID: 30271493   DOI: 10.7150/jca.25666
4078  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Medicinal Chemistry Research  2018  27:2366–2378    DOI: 10.1007/s00044-018-2242-5
4401  Tamaki NAKANISHI and Koichi IMAI  Interleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells  Nano Biomedicine  2018  10, 77-82    DOI: 10.11344/nano.10.77
4402  Tamaki NAKANISHI, Kaname TSUJI, Yuki MATSUSHIMA, Koji YAMADA, Kazuhiro MATSUMOTO, Hiroaki YOSHIDA, Tomio ISEKI, Hideo SHIMIZU, Shosuke MORITA  Interleukin-6 Expression in Three-dimensional Tumor Microenvironment using HSC-4 Cells  Nano Biomedicine   2018  10, 21-25    DOI: 10.11344/nano.10.21
4173  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  In Vivo  2018    PubMed ID: 29695558   DOI: 10.21873/invivo.11273
4183  Ohara K, Ohkuri T, Kumai T, Nagato T, Nozaki Y, Ishibashi K, Kosaka A, Nagata M, Harabuchi S, Ohara M, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H.  Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma.  Oncoimmunology  2018    PubMed ID: 30510853   DOI: 10.1080/2162402X.2018.1466771
4235  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Oncotarget  2018    PubMed ID: 30333913   DOI: 10.18632/oncotarget.26112
4237  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Mol Clin Oncol  2018    PubMed ID: 29456845   DOI: 10.3892/mco.2018.1548
4240  Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M.  DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.  Arch. Oral Biol.  2018    PubMed ID: 29522917   DOI: 10.1016/j.archoralbio.2018.02.016
4241  Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI.  Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.  Oncol. Rep.  2018    PubMed ID: 30132562   DOI: 10.3892/or.2018.6665
4242  Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.  Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.  Int. J. Oncol.  2018    PubMed ID: 29115586   DOI: 10.3892/ijo.2017.4181
4243  Kinouchi M, Izumi S, Nakashiro KI, Haruyama Y, Kobashi G, Uchida D, Hasegawa T, Kawamata H.  Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?  Int. J. Cancer  2018    PubMed ID: 30121960   DOI: 10.1002/ijc.31811
6022  Yakop F, Abd Ghafar SA, Yong YK, Saiful Yazan L, Mohamad Hanafiah R, Lim V, Eshak Z.  Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines.  Artif Cells Nanomed Biotechnol  2018  46(sup2):131-139  PubMed ID: 29561182   DOI: 10.1080/21691401.2018.1452750
14544  Yuichi OHNISHI, Hiroki YASUI, Kazutaka KIMURA, Masahiro WATANABE, Tomoko FUJII, Hiroyuki HAMADA, Yuri MUROI, Tomokazu MOTOHASHI, Hirohito KUBO, Masaki AKANE, Masayuki TSUNOKUMA, Masahiro NAKAJIMA  Hepatocyte growth factor increases the invasive potential of human oral cancer cells  Journal of Osaka Dental University  2018  52:69-74    DOI: 10.18905/jodu.52.1_69
16201  Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K.  Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer  Lab Invest  2018  98(8):980-988  PubMed ID: 29855544   DOI: 10.1038/s41374-018-0070-3
10148  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246   DOI: 10.1016/j.yexcr.2017.02.026
10155  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Sci Rep  2017  7:43379  PubMed ID: 28230172   DOI: 10.1038/srep43379
10191  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328   DOI: 10.1016/j.bbrc.2017.03.050
10197  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260   DOI: 10.21873/anticanres.11412
10201  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269   DOI: 10.21873/anticanres.11421
10206  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Molecules  2017  22:  PubMed ID: 28294988   DOI: 10.3390/molecules22030470
10241  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677   DOI: 10.1248/cpb.c16-00830
10386  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  In Vivo  2017  31:591-598  PubMed ID: 28652425   DOI: 10.21873/invivo.11099
10418  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404   DOI: 10.7150/jca.18714
10572  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798   DOI: 10.21873/anticanres.12066
10576  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797   DOI: 10.21873/anticanres.12065
10600  Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y.  Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.  Int J Mol Sci  2017  18:  PubMed ID: 29112119   DOI: 10.3390/ijms18112358
10961    HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin  J Osaka Dent Univ  2017  51 : 1−8    DOI: 10.18905/jodu.51.1_1
11036    Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation  Int J Cancer Oncol  2017  4: 225- 230    DOI: 10.15436/2377-0902.17.1628
4574  Yasui H, Ohnishi Y, Nakajima M, Nozaki M.  Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.  Oncol Rep  2017  37(6):3674-3680  PubMed ID: 28440510   DOI: 10.3892/or.2017.5587
6029  Ishida S et al  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725   DOI: 10.1016/j.bbrc.2016.12.142
12679  Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K.  Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential  Cancer Res  2017  77(9):2363-2374  PubMed ID: 28209617   DOI: 10.1158/0008-5472.CAN-16-2114
14638  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Regulation of cell migration via the EGFR signaling pathway in oral squamous cell carcinoma cells  Oncol Lett  2017  13(2):930-936  PubMed ID: 28356980   DOI: 10.3892/ol.2016.5500
9584  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  In Vivo  2016  30:91-7  PubMed ID: 26912818  
9616  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  J Cancer  2016  7:600-7  PubMed ID: 27053959   DOI: 10.7150/jca.13820
9630  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  J Cancer  2016  7:702-10  PubMed ID: 27076852   DOI: 10.7150/jca.14208
9676  Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A.  Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.  Anticancer Res.  2016  36:2161-8  PubMed ID: 27127118  
9694  Harada K, Ferdous T, Harada T, Ueyama Y.  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058   DOI: 10.3892/ijo.2016.3523
9762  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818   DOI: 10.1371/journal.pone.0159693
9808  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  In Vivo  2016  30:645-50  PubMed ID: 27566085  
9892  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902   DOI: 10.21873/anticanres.11164
9896  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918   DOI: 10.21873/anticanres.11180
9911  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  Antiviral and Antitumor Activity of Licorice Root Extracts.  In Vivo  2016  30:777-785  PubMed ID: 27815461   DOI: 10.21873/invivo.10994
9935  Suganya S AA, Kochurani KJ, Nair MG, Louis JM, Sankaran S, Rajagopal R, Kumar KS, Abraham P, P G B, Sebastian P, Somananthan T, Maliekal TT.  TM1-IR680 peptide for assessment of surgical margin and lymph node metastasis in murine orthotopic model of oral cancer.  Sci Rep  2016  6:36726  PubMed ID: 27827443   DOI: 10.1038/srep36726
5809  Ninomiya K et al  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  J Nat Med   2016  70(3):435-51  PubMed ID: 27178360   DOI: 10.1007/s11418-016-0998-9
5810  Kitagawa N et al  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.  Int J Mol Sci  2016  17(12). pii: E1979  PubMed ID: 27898032   DOI: 10.3390/ijms17121979
6032  Tada H, Shimizu T, Nagaoka I, Takada H.  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607   DOI: 10.2220/biomedres.37.199
6033  Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R.  Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.  Int J Oncol  2016  48(4):1670-8  PubMed ID: 26893131   DOI: 10.3892/ijo.2016.3391
6036  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916   DOI: 10.3892/ijo.2015.3305
6042  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332   DOI: 10.1002/mc.22347
13988  Ishibashi K, Kumai T, Ohkuri T, Kosaka A, Nagato T, Hirata Y, Ohara K, Oikawa K, Aoki N, Akiyama N, Sado M, Kitada M, Harabuchi Y, Celis E, Kobayashi H.  Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy  Oncoimmunology  2016  5(6):e1169356  PubMed ID: 27471649   DOI: 10.1080/2162402X.2016.1169356
14162  Yamali C, Gul HI, Sakagami H, Supuran CT.  Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases  J Enzyme Inhib Med Chem  2016  31(sup4):125-131  PubMed ID: 27594305   DOI: 10.1080/14756366.2016.1221825
14178  Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T.  Hydrolyzable Tannins of Tamaricaceous Plants. 7.1 Structures and Cytotoxic Properties of Oligomeric Ellagitannins from Leaves of Tamarix nilotica and Cultured Tissues of Tamarix tetrandra  J Nat Prod  2016  79(4):984-95  PubMed ID: 26938659   DOI: 10.1021/acs.jnatprod.5b01065
7109  Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K.  Telomerase activity in the occurrence and progression of oral squamous cell carcinoma.  J Oral Sci  2015  57:295-303  PubMed ID: 26666852   DOI: 10.2334/josnusd.57.295
7175  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.  Int. J. Oncol.  2015  47:2165-72  PubMed ID: 26497980   DOI: 10.3892/ijo.2015.3215
7196  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690  
7283  Uzawa K, Kasamatsu A, Baba T, Kimura Y, Nakashima D, Higo M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H.  Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer.  Int. J. Oncol.  2015  47:1077-83  PubMed ID: 26179426   DOI: 10.3892/ijo.2015.3083
5422  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695  
6043  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471   DOI: 10.1016/j.toxrep.2015.09.009
6044  Kasama H et al   Adenosine A2b receptor promotes progression of human oral cancer.  BMC Cancer  2015  15:563  PubMed ID: 26228921   DOI: 10.1186/s12885-015-1577-2
6051  Okamoto A et al  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377   DOI: 10.1371/journal.pone.0142252
6052  Saito T et al  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920   DOI: 10.1371/journal.pone.0137923
6053  Miyamoto I et al  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166   DOI: 10.1016/j.bbrep.2015.07.008
6054  Baba T et al  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483   DOI: 10.1002/mc.22127
14987  Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H.  Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression  Oncotarget  2015  6(32):33345-57  PubMed ID: 26452260   DOI: 10.18632/oncotarget.5428
15042  Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer  Cancer Med  2015  4(5):759-69  PubMed ID: 25644496   DOI: 10.1002/cam4.418
15057  Ohmura G, Tsujikawa T, Yaguchi T, Kawamura N, Mikami S, Sugiyama J, Nakamura K, Kobayashi A, Iwata T, Nakano H, Shimada T, Hisa Y, Kawakami Y.  Aberrant Myosin 1b Expression Promotes Cell Migration and Lymph Node Metastasis of HNSCC  Mol Cancer Res  2015  13(4):721-31  PubMed ID: 25421751   DOI: 10.1158/1541-7786.MCR-14-0410
15186  Kumai T, Matsuda Y, Ohkuri T, Oikawa K, Ishibashi K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  c-Met is a novel tumor associated antigen for T-cell based immunotherapy against NK/T cell lymphoma  Oncoimmunology  2015  4(2):e976077  PubMed ID: 25949874   DOI: 10.4161/2162402X.2014.976077
10985  Kumai T, Ohkuri T, Nagato T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Celis E, Harabuchi Y, Kobayashi H.  Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma  Sci Rep  2015  5:16280  PubMed ID: 26538233   DOI: 10.1038/srep16280
6056  Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y.  Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.  Anticancer Res  2014  34(8):4117-20  PubMed ID: 25075037  
6023  Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M.  NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma.  Oncol Lett  2014  7(1):35-40  PubMed ID: 24348816   DOI: 10.3892/ol.2013.1690
5916  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  In Vivo  2014  28(4):549-56  PubMed ID: 24982221  
5859  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344   DOI: 10.2220/biomedres.35.381
5807  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906  
5659  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035  
5544  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367  
5337  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069  
5307  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.  J Transl Med  2014  12:265  PubMed ID: 25240937   DOI: 10.1186/s12967-014-0265-3
16010  Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K.  WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice  Oncoscience  2014  1(12):807-20  PubMed ID: 25621296   DOI: 10.18632/oncoscience.101
5190  Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.  Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.  Acta Med Okayama  2013  67(3):153-64  PubMed ID: 23804138   DOI: 10.18926/AMO/50408
5122  Iida S, Shimada J, Sakagami H.  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687  
5110  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061  
5057  Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y.  Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.  Int J Cancer.  2013  132(12):2755-66  PubMed ID: 23180648   DOI: 10.1002/ijc.27966
5028  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234   DOI: 10.1007/s00432-012-1361-5
6067  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766   DOI: 10.3892/ijo.2012.1677
6070  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790   DOI: 10.1007/s00432-012-1356-2
6072  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564   DOI: 10.1371/journal.pone.0056381
6074  Shimizu F1, Shiiba M2, Ogawara K3, Kimura R1, Minakawa Y1, Baba T1, Yokota S, Nakashima D1, Higo M3, Kasamatsu A3, Sakamoto Y3, Tanzawa H4, Uzawa K4.  Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.  PLoS One  2013  8(12):e83187  PubMed ID: 24386158   DOI: 10.1371/journal.pone.0083187
6076  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490   DOI: 10.1371/journal.pone.0085951
6077  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247   DOI: 10.1111/j.1600-0714.2012.01182.x
6078  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548   DOI: 10.1007/s10719-012-9458-2
6083  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 24045666   DOI: 10.1038/bjc.2013.577
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
7722  Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K.  Comprehensive epigenetic analysis using oral rinse samples: a pilot study.  J. Oral Maxillofac. Surg.  2012  70:1486-94  PubMed ID: 21821326   DOI: 10.1016/j.joms.2011.04.021
6087  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889   DOI: 10.2334/josnusd.54.71
6088  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311   DOI: 10.1002/path.3993
6089  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  J Oral Sci  2012  54(3):241-50  PubMed ID: 23047035   DOI: 10.2334/josnusd.54.241
6094  Yuichi Ohnishi et al  Analysis of a cancer stem cell marker EpCAM in an oral squamous cell carcinoma cell line as monolayers and multicellular aggregates  Journal of Osaka Dental University  2012  46:215-220    DOI: 10.18905/jodu.46.2_215
6095  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894   DOI: 10.3892/ol.2011.473
6098  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Tumour Biol  2012  33(1):183-94  PubMed ID: 22081310   DOI: 10.1007/s13277-011-0261-7
15671  Harada T, Harada K, Ueyama Y.  The enhancement of tumor radioresponse by combined treatment with cepharanthine is accompanied by the inhibition of DNA damage repair and the induction of apoptosis in oral squamous cell carcinoma  Int J Oncol  2012  41(2):565-72  PubMed ID: 22664937   DOI: 10.3892/ijo.2012.1501
7601  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286  
6109  Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M.  A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.  Int J Oncol  2011  39(6):1401-5  PubMed ID: 21785818   DOI: 10.3892/ijo.2011.1137
6111  Hiroshi Inoue, Yuichi Ohnishi, Masahiro Watanabe, Tomoko Fujii, Yuki Minamino, Yoshihide Ugaki, Suguru Dateoka, Mitsuchika Sugitatsu, Masayuki Tsunokuma, Hirohito Kubo, Masahiro Nakajima, Kenji Kakudo  Effect of EpCAM localization on proliferation of an oral squamous cell carcinoma cell line  Journal of Osaka Dental UniversityJournal of Osaka Dental University  2011  45:259-264    DOI: 10.18905/jodu.45.2_259
6112  lHiroshi Inoue et al  Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines  Asian Journal of Oral and Maxillofacial Surgery   2011  23:1-6    DOI: 10.1016/j.ajoms.2010.10.001
6116  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983   DOI: 10.3892/or.2010.1130
6118  Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo  Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer  Journal of Osaka Dental University  2011  45:31-36    DOI: 10.18905/jodu.45.1_31
8085  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  In Vivo  2010  24:735-43  PubMed ID: 20952742  
18753  Kimura S, Naganuma S, Susuki D, Hirono Y, Yamaguchi A, Fujieda S, Sano K, Itoh H.  Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC  Oncol Rep  2010  23(6):1625-33  PubMed ID: 20428818   DOI: 10.3892/or_00000804
5611  Wakabayashi H, Narita T, Suga A, Sakagami H.  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973  
6120  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673   DOI: 10.1016/j.bbrc.2009.12.156
6122  Nomi N, Kodama S, Suzuki M.  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466   DOI: 10.3892/or_00000850
6123  Yuji Miyazaki et al  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  J Cancer Sci Ther  2010  2(2) :26-32   
8490  Saitoh Y, Yoshimura Y, Nakano K, Miwa N.  Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells.  Exp. Oncol.  2009  31:156-62  PubMed ID: 19783965  
8558  Ozawa H, Mutai H, Matsunaga T, Tokumaru Y, Fujii M, Sakamoto K, Tomita T, Ogawa K.  Promoted cell proliferation by connexin 30 gene transfection to head-and-neck cancer cell line.  Anticancer Res.  2009  29:1981-5  PubMed ID: 19528455  
6127  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319  
6128  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186  
6129  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354  
18691  Shimizu M, Imai M.  Effect of the antibody immunotherapy by the anti-MUC1 monoclonal antibody to the oral squamous cell carcinoma in vitro  Biol Pharm Bull  2008  31(12):2288-93  PubMed ID: 19043215   DOI: 10.1248/bpb.31.2288
6136  Okamura M, Shimada J, Sakagami H.  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853  
6138  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Anticancer Res  2008  28(2A):1069-78  PubMed ID: 18507056  
6141  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558   DOI: 10.1111/j.1349-7006.2008.00838.x
6143  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225  
6148  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125  
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158

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15485  大西 祐一, 渡辺 昌広, 安井 大樹, 藤井 智子, 伊達岡 聖, 窪 寛仁, 木村 一貴, 赤根 昌樹, 覚道 健治  セツキシマブ耐性口腔扁平上皮癌細胞における自律増殖性の解析  歯科医学  2015  78:57-63    DOI: 10.18905/shikaigaku.78.2_57
6108  渡辺 昌広, 大西 祐一, 藤井 智子, 南野 友希, 宇垣 吉秀, 井上 洋士, 伊達岡 聖, 杉立 光史, 中嶋 正博, 覚道 健治  口腔扁平上皮癌におけるCyclin D1の細胞内局在と増殖能との関連  歯科医学  2012  75:70-75    DOI: 10.18905/shikaigaku.75.2_70



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