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RCB1902 : HSC-4  update : 2019/10/07
CommentHuman tongue squamous cell carcinoma derived cell line. TKG0489 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Obinata, Masuo
Year of deposit 2004
Original cell TKG0489
Animal human < Mammals
Genus Homo
Species sapiens
Tissue tongue
Case history Squamous cell carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0489)
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Images
deposit info
lot info
Reference information Reference 4
User's Publication 124


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Reference
3303  Growth of the malignant and nonmalignant human squamous cells in a protein-free defined medium.  Rikimaru K, Toda H, Tachikawa N, Kamata N, Enomoto S.  In Vitro Cell Dev Biol  1990  26:849-856  PubMed ID: 2228902
3089  Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line.  Miyazaki K, Takaku H, Umeda M, Fujita T, Huang WD, Kimura T, Yamashita J, Horio T  Cancer Res  1990  50:4522-7  PubMed ID: 2164440
3248  Biological effects and binding properties of transforming growth factor-beta on human oral squamous cell carcinoma cells.  Ichijo H, Momose F, Miyazono K  Exp Cell Res  1990  187:263-9  PubMed ID: 2156718
3243  Variant sublines with different metastatic potentials selected in nude mice from human oral squamous cell carcinomas.  Momose F, Araida T, Negishi A, Ichijo H, Shioda S, Sasaki S  J Oral Pathol Med  1989  18:391-5  PubMed ID: 2585303

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User's Publication
7109  Telomerase activity in the occurrence and progression of oral squamous cell carcinoma.  Miyazaki Y, Yoshida N, Nozaki T, Inoue H, Kikuchi K, Kusama K.  J Oral Sci  2015  57:295-303  PubMed ID: 26666852
7175  Cetuximab-resistant oral squamous cell carcinoma cells become sensitive in anchorage-independent culture conditions through the activation of the EGFR/AKT pathway.  Ohnishi Y, Yasui H, Kakudo K, Nozaki M.  Int. J. Oncol.  2015  47:2165-72  PubMed ID: 26497980
7196  Quantitative Structure-Cytotoxicity Relationship of 3-Styryl-2H-chromenes.  Uesawa Y, Sakagami H, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Yahagi H, Takao K, Sugita Y.  Anticancer Res.  2015  35:5299-307  PubMed ID: 26408690
7283  Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer.  Uzawa K, Kasamatsu A, Baba T, Kimura Y, Nakashima D, Higo M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H.  Int. J. Oncol.  2015  47:1077-83  PubMed ID: 26179426
7601  Quantitative structure-activity relationship (QSAR) analysis of tumor-specificity of 1,2,3,4-tetrahydroisoquinoline derivatives.  Uesawa Y, Mohri K, Kawase M, Ishihara M, Sakagami H.  Anticancer Res.  2011  31:4231-8  PubMed ID: 22199286
7722  Comprehensive epigenetic analysis using oral rinse samples: a pilot study.  Kusumoto T, Hamada T, Yamada N, Nagata S, Kanmura Y, Houjou I, Kamikawa Y, Yonezawa S, Sugihara K.  J. Oral Maxillofac. Surg.  2011  70:1486-94  PubMed ID: 21821326
8085  Multiple biological complex of alkaline extract of the leaves of Sasa senanensis Rehder.  Sakagami H, Zhou L, Kawano M, Thet MM, Tanaka S, Machino M, Amano S, Kuroshita R, Watanabe S, Chu Q, Wang QT, Kanamoto T, Terakubo S, Nakashima H, Sekine K, Shirataki Y, Zhang CH, Uesawa Y, Mohri K, Kitajima M, Oizumi H, Oizumi T.  In Vivo  2010  24:735-43  PubMed ID: 20952742
8490  Platinum nanocolloid-supplemented hydrogendissolved water inhibits growth of human tongue carcinoma cells preferentially over normal cells.  Saitoh Y, Yoshimura Y, Nakano K, Miwa N.  Exp. Oncol.  2009  31:156-62  PubMed ID: 19783965
8558  Promoted cell proliferation by connexin 30 gene transfection to head-and-neck cancer cell line.  Ozawa H, Mutai H, Matsunaga T, Tokumaru Y, Fujii M, Sakamoto K, Tomita T, Ogawa K.  Anticancer Res.  2009  29:1981-5  PubMed ID: 19528455
9584  Quest for Cells Responsible for Age-related Increase of Salivary Glycine and Proline.  Hino S, Nishiyama A, Matsuta T, Horie N, Shimoyama T, Tanaka S, Sakagami H.  In Vivo  2016  30:91-7  PubMed ID: 26912818
9616  Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas.  Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:600-7  PubMed ID: 27053959
9630  ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma.  Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2016  7:702-10  PubMed ID: 27076852
9676  Synthetic Terrein Inhibits Progression of Head and Neck Cancer by Suppressing Angiogenin Production.  Shibata A, Ibaragi S, Mandai H, Tsumura T, Kishimoto K, Okui T, Hassan NM, Shimo T, Omori K, Hu GF, Takashiba S, Suga S, Sasaki A.  Anticancer Res.  2016  36:2161-8  PubMed ID: 27127118
9694  Metformin in combination with 5-fluorouracil suppresses tumor growth by inhibiting the Warburg effect in human oral squamous cell carcinoma.  Harada K, Ferdous T, Harada T, Ueyama Y.  Int. J. Oncol.  2016  49:276-84  PubMed ID: 27210058
9762  Circulating miR-223 in Oral Cancer: Its Potential as a Novel Diagnostic Biomarker and Therapeutic Target.  Tachibana H, Sho R, Takeda Y, Zhang X, Yoshida Y, Narimatsu H, Otani K, Ishikawa S, Fukao A, Asao H, Iino M.  PLoS ONE  2016  11:e0159693  PubMed ID: 27441818
9808  Enhancement of Cytotoxicity of Three Apoptosis-inducing Agents Against Human Oral Squamous Cell Carcinoma Cell Line by Benzoxazinotropone.  Tomikoshi Y, Nomura M, Okudaira N, Sakagami H, Wakabayashi H.  In Vivo  2016  30:645-50  PubMed ID: 27566085
9892  Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones.  Uesawa Y, Sakagami H, Kagaya H, Yamashita M, Takao K, Sugita Y.  Anticancer Res.  2016  36:5803-5812  PubMed ID: 27793902
9896  Cytotoxic Components Against Human Oral Squamous Cell Carcinoma Isolated from Andrographis paniculata.  Suzuki R, Matsushima Y, Okudaira N, Sakagami H, Shirataki Y.  Anticancer Res.  2016  36:5931-5935  PubMed ID: 27793918
9911  Antiviral and Antitumor Activity of Licorice Root Extracts.  Fukuchi K, Okudaira N, Adachi K, Odai-Ide R, Watanabe S, Ohno H, Yamamoto M, Kanamoto T, Terakubo S, Nakashima H, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2016  30:777-785  PubMed ID: 27815461
9935  TM1-IR680 peptide for assessment of surgical margin and lymph node metastasis in murine orthotopic model of oral cancer.  Suganya S AA, Kochurani KJ, Nair MG, Louis JM, Sankaran S, Rajagopal R, Kumar KS, Abraham P, P G B, Sebastian P, Somananthan T, Maliekal TT.  Sci Rep  2016  6:36726  PubMed ID: 27827443
10148  SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7.  Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2017  352:357-363  PubMed ID: 28237246
10155  Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer.  Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  Sci Rep  2017  7:43379  PubMed ID: 28230172
10191  TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase.  Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  Biochem. Biophys. Res. Commun.  2017  486:385-390  PubMed ID: 28315328
10197  Induction of Apoptosis in Human Oral Keratinocyte by Doxorubicin.  Sakagami H, Okudaira N, Masuda Y, Amano O, Yokose S, Kanda Y, Suguro M, Natori T, Oizumi H, Oizumi T.  Anticancer Res.  2017  37:1023-1029  PubMed ID: 28314260
10201  Quantitative Structure-Cytotoxicity Relationship of Chalcones.  Sakagami H, Masuda Y, Tomomura M, Yokose S, Uesawa Y, Ikezoe N, Asahara D, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:1091-1098  PubMed ID: 28314269
10206  Ellagitannins of Davidia involucrata. I. Structure of Davicratinic Acid A and Effects of Davidia Tannins on Drug-Resistant Bacteria and Human Oral Squamous Cell Carcinomas.  Shimozu Y, Kimura Y, Esumi A, Aoyama H, Kuroda T, Sakagami H, Hatano T.  Molecules  2017  22:  PubMed ID: 28294988
10241  A Novel Methodology for Synthesis of 1,5,6-Trisubstituted 2(1H)-Pyrazinones of Biological Interest.  Saijo R, Sekiya H, Tamai E, Kurihara KI, Maki J, Sakagami H, Kawase M.  Chem. Pharm. Bull.  2017  65:365-372  PubMed ID: 28381677
10386  Evaluation of Biological Activity of Mastic Extracts Based on Chemotherapeutic Indices.  Suzuki R, Sakagami H, Amano S, Fukuchi K, Sunaga K, Kanamoto T, Terakubo S, Nakashima H, Shirataki Y, Tomomura M, Masuda Y, Yokose S, Tomomura A, Watanabe H, Okawara M, Matahira Y.  In Vivo  2017  31:591-598  PubMed ID: 28652425
10418  Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis.  Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2017  8:2033-2041  PubMed ID: 28819404
10572  Quantitative Structure-Cytotoxicity Relationship of Aurones.  Uesawa Y, Sakagami H, Ikezoe N, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2017  37:6169-6176  PubMed ID: 29061798
10576  Quantitative Structure-Cytotoxicity Relationship of Newly Synthesized Piperic Acid Esters.  Sakagami H, Uesawa Y, Masuda Y, Tomomura M, Yokose S, Miyashiro T, Murai J, Takao K, Kanamoto T, Terakubo S, Kagaya H, Nakashima H, Sugita Y.  Anticancer Res.  2017  37:6161-6168  PubMed ID: 29061797
10600  Steroidal Glycosides from Convallaria majalis Whole Plants and Their Cytotoxic Activity.  Matsuo Y, Shinoda D, Nakamaru A, Kamohara K, Sakagami H, Mimaki Y.  Int J Mol Sci  2017  18:  PubMed ID: 29112119
10664  Molecularly-targeted therapy for the oral cancer stem cells.  Ohnishi Y, Yasui H, Nozaki M, Nakajima M.  Jpn Dent Sci Rev  2018  54:88-103  PubMed ID: 29755619
10682  Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer.  Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Biochem. Biophys. Res. Commun.  2018  495:2469-2474  PubMed ID: 29278705
10724  Quantitative Structure-Cytotoxicity Relationship of Cinnamic Acid Phenetyl Esters.  Uesawa Y, Sakagami H, Okudaira N, Toda K, Takao K, Kagaya H, Sugita Y.  Anticancer Res.  2018  38:817-823  PubMed ID: 29374707
10806  Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression.  Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K.  Exp. Cell Res.  2018  367:112-118  PubMed ID: 29614312
10829  In Vitro Anti-tumor Activity of Azulene Amide Derivatives.  Wada T, Maruyama R, Irie Y, Hashimoto M, Wakabayashi H, Okudaira N, Uesawa Y, Kagaya H, Sakagami H.  In Vivo  2018  32:479-486  PubMed ID: 29695549
10961  HGF/c-Met induces cell migration of oral squamous cell carcinoma via lamellipodin    J Osaka Dent Univ  2017  51 : 1−8 
11036  Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation    Int J Cancer Oncol  2017  4: 225- 230 
11086  Quantitative Structure-Cytotoxicity Relationship of Furo[2,3-b]chromones.  Uesawa Y, Sakagami H, Shi H, Hirose M, Takao K, Sugita Y.  Anticancer Res.  2018  38(6):3283-3290  PubMed ID: 29848675
11110  Partial Protection of Paclitaxel-induced Neurotoxicity by Antioxidants.  Hara Y, Sakagami H, Shi H, Abe T, Tamura N, Takeshima H, Horie N, Kaneko T, Shiratsuchi H, Kaneko T.  In Vivo  2018  32(4):745-752  PubMed ID: 29936454
11115  Quantitative Structure-Cytotoxicity Relationship of 2-(N-cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Sakagami H, Tomomura M, Tomomura A, Uesawa Y, Takao K, Sugita Y.  Anticancer Res.  2018  38(7):3897-3906  PubMed ID: 29970510
11148  Quantitative Structure-Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives.  Shi H, Nagai J, Sakatsume T, Bandow K, Okudaira N, Uesawa Y, Sakagami H, Tomomura M, Tomomura A, Takao K, Sugita Y.  Anticancer Res.  2018  38(8):4459-4467  PubMed ID: 30061210
11226  Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer.  Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  J Cancer  2018    PubMed ID: 30271493
11354  Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression.  Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30587341
4078  Cytotoxicity, apoptosis, and QSAR studies of phenothiazine derived methoxylated chalcones as anticancer drug candidates  Halise Inci, Cem Yamali, Gulsen Gunesacar, Hiroshi Sakagami, Noriyuki Okudaira, Yoshihiro Uesawa, Hajime Kagaya  Medicinal Chemistry Research  2018  27:2366–2378 
4401  Interleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells  Tamaki NAKANISHI and Koichi IMAI  Nano Biomedicine  2018  10, 77-82, 
4402  Interleukin-6 Expression in Three-dimensional Tumor Microenvironment using HSC-4 Cells  Tamaki NAKANISHI, Kaname TSUJI, Yuki MATSUSHIMA, Koji YAMADA, Kazuhiro MATSUMOTO, Hiroaki YOSHIDA, Tomio ISEKI, Hideo SHIMIZU, Shosuke MORITA  Nano Biomedicine   2018  10, 21-25 
4403  Hepatocyte growth factor increases the invasive potential of human oral cancer cells    J Osaka Dent Univ  2018  52 : 69−74 
4173  In Vitro Antitumor Activity of Alkylaminoguaiazulenes.  Uehara M, Minemura H, Ohno T, Hashimoto M, Wakabayashi H, Okudaira N, Sakagami H.  In Vivo  2018    PubMed ID: 29695558
4183  Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma.  Ohara K, Ohkuri T, Kumai T, Nagato T, Nozaki Y, Ishibashi K, Kosaka A, Nagata M, Harabuchi S, Ohara M, Oikawa K, Aoki N, Harabuchi Y, Celis E, Kobayashi H.  Oncoimmunology  2018    PubMed ID: 30510853
4235  Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.  Okazaki S, Shintani S, Hirata Y, Suina K, Semba T, Yamasaki J, Umene K, Ishikawa M, Saya H, Nagano O.  Oncotarget  2018    PubMed ID: 30333913
4237  Low carbonyl reductase 1 expression is associated with poor prognosis in patients with oral squamous cell carcinoma.  Yamanouchi R, Harada K, Ferdous T, Ueyama Y.  Mol Clin Oncol  2018    PubMed ID: 29456845
4240  DNA damage response following X-irradiation in oral cancer cell lines HSC3 and HSC4.  Jiaranuchart S, Kaida A, Onozato Y, Harada H, Miura M.  Arch. Oral Biol.  2018    PubMed ID: 29522917
4241  Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma.  Sumita Y, Yamazaki M, Maruyama S, Abé T, Cheng J, Takagi R, Tanuma JI.  Oncol. Rep.  2018    PubMed ID: 30132562
4242  Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer.  Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J, Daigo Y.  Int. J. Oncol.  2018    PubMed ID: 29115586
4243  Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?  Kinouchi M, Izumi S, Nakashiro KI, Haruyama Y, Kobashi G, Uchida D, Hasegawa T, Kawamata H.  Int. J. Cancer  2018    PubMed ID: 30121960
4574  Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.  Yasui H, Ohnishi Y, Nakajima M, Nozaki M.  Oncol Rep  2017  37(6):3674-3680  PubMed ID: 28440510
5422  Quantitative Structure-Cytotoxicity Relationship of Oleoylamides.  Sakagami H, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y5.  Anticancer Res  2015  5(10):5341-51  PubMed ID: 26408695
5611  Hormetic response of cultured normal and tumor cells to 2-aminotropone derivatives.  Wakabayashi H, Narita T, Suga A, Sakagami H.  In Vivo  2010  24(1):39-44  PubMed ID: 20133973
5809  Acylated oleanane-type triterpene saponins from the flowers of Bellis perennis show anti-proliferative activities against human digestive tract carcinoma cell lines.  Ninomiya K et al  J Nat Med   2016  70(3):435-51  PubMed ID: 27178360
5810  The Antiproliferative Effect of Chakasaponins I and II, Floratheasaponin A, and Epigallocatechin 3-O-Gallate Isolated from Camellia sinensis on Human Digestive Tract Carcinoma Cell Lines.  Kitagawa N et al  Int J Mol Sci  2016  17(12). pii: E1979  PubMed ID: 27898032
6018  nterleukin-6 expression in three-dimensional tumor microenvironment using HSC-4 cells  Tamaki NAKANISHI et al  Nano Biomedicine  2018  10(1) 
6019  nterleukin-6, Matrix Metallopeptidase-9 Expression in Three-dimensional Tumor Microenvironment using Oral Cancer Cells  amaki NAKANISHI and Koichi IMAI  Nano Biomedicine  2018  10(2):77-82 
6022  Silver nanoparticles Clinacanthus Nutans leaves extract induced apoptosis towards oral squamous cell carcinoma cell lines.  Yakop F, Abd Ghafar SA, Yong YK, Saiful Yazan L, Mohamad Hanafiah R, Lim V, Eshak Z.  Artif Cells Nanomed Biotechnol  2018  46(sup2):131-139  PubMed ID: 29561182
6029  Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis.  Ishida S et al  Biochem Biophys Res Commun  2017  483(1):339-345  PubMed ID: 28017725
6032  Vitamin D3 analog maxacalcitol (OCT) induces hCAP-18/LL-37 production in human oral epithelial cells.  Tada H, Shimizu T, Nagaoka I, Takada H.  Biomed Res  2016  37(3):199-205  PubMed ID: 27356607
6033  Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.  Shimizu T, Kawai J, Ouchi K, Kikuchi H, Osima Y, Hidemi R.  Int J Oncol  2016  48(4):1670-8  PubMed ID: 26893131
6036  Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer.  Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K.  Int J Oncol.  2016  48(2):607-12  PubMed ID: 26718916
6042  Cavin-2 in oral cancer: A potential predictor for tumor progression.  Unozawa M, Kasamatsu A, Higo M, Fukumoto C, Koyama T, Sakazume T, Nakashima D, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa  Mol Carcinog  2016  55(6):1037-47  PubMed ID: 26086332
6043  Effects of 3-styrylchromones on metabolic profiles and cell death in oral squamous cell carcinoma cells.  Sakagami H, Shimada C, Kanda Y, Amano O, Sugimoto M, Ota S, Soga T, Tomita M, Sato A, Tanuma SI, Takao K, Sugita Y.  Toxicol Rep  2015  2:1281-1290  PubMed ID: 28962471
6044  Adenosine A2b receptor promotes progression of human oral cancer.  Kasama H et al   BMC Cancer  2015  15:563  PubMed ID: 26228921
6051  Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma.  Okamoto A et al  PLoS One  2015  10(11):e0142252  PubMed ID: 26554377
6052  Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis.  Saito T et al  PLoS One  2015  10(9):e0137923  PubMed ID: 26378920
6053  Kinesin family member 14 in human oral cancer: A potential biomarker for tumoral growth.  Miyamoto I et al  Biochem Biophys Rep  2015  3:26-31  PubMed ID: 29124166
6054  Persephin: A potential key component in human oral cancer progression through the RET receptor tyrosine kinase-mitogen-activated protein kinase signaling pathway.  Baba T et al  Mol Carcinog  2015  54(8):608-17  PubMed ID: 24375483
6056  Search of new cytotoxic crude materials against human oral squamous cell carcinoma using 1H NMR-based metabolomics.  Suzuki R, Matsuno S, Sakagami H, Okada Y, Shirataki Y.  Anticancer Res  2014  34(8):4117-20  PubMed ID: 25075037
6023  NANOG expression correlates with differentiation, metastasis and resistance to preoperative adjuvant therapy in oral squamous cell carcinoma.  Watanabe M, Ohnishi Y, Inoue H, Wato M, Tanaka A, Kakudo K, Nozaki M.  Oncol Lett  2014  7(1):35-40  PubMed ID: 24348816
5916  Cytotoxicity and pro-inflammatory action of chemo-mechanical caries-removal agents against oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H  In Vivo  2014  28(4):549-56  PubMed ID: 24982221
5859  Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.  Miyamoto C, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.  Biomed Res.  2014  35(6):381-8  PubMed ID: 25743344
5807  Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.  Garcia-Contreras R, Scougall-Vilchis RJ, Contreras-Bulnes R, Kanda Y, Nakajima H, Sakagami H.  In Vivo  2014  28(5):895-907  PubMed ID: 25189906
5659  Quantitative structure-cytotoxicity relationship of 3-styrylchromones.  Shimada C, Uesawa Y, Ishii-Nozawa R, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Sugita Y, Sakagami H.  Anticancer Res  2014  34(10):5405-11  PubMed ID: 25275035
5544  Quantitative structure-cytotoxicity relationship of phenylpropanoid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Saito T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(7):3543-8  PubMed ID: 24982367
5337  Quantitative structure-cytotoxicity relationship of piperic acid amides.  Shimada C, Uesawa Y, Ishihara M, Kagaya H, Kanamoto T, Terakubo S, Nakashima H, Takao K, Miyashiro T, Sugita Y, Sakagami H.  Anticancer Res  2014  34(9):4877-84  PubMed ID: 25202069
5307  Tumor-derived TGF-β and prostaglandin E2 attenuate anti-tumor immune responses in head and neck squamous cell carcinoma treated with EGFR inhibitor.  Kumai T, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  J Transl Med  2014  12:265  PubMed ID: 25240937
5190  Improvement of the efficacy of 5-aminolevulinic acid-mediated photodynamic treatment in human oral squamous cell carcinoma HSC-4.  Yamamoto M, Fujita H, Katase N, Inoue K, Nagatsuka H, Utsumi K, Sasaki J, Ohuchi H.  Acta Med Okayama  2013  67(3):153-64  PubMed ID: 23804138
5122  Cytotoxicity induced by docetaxel in human oral squamous cell carcinoma cell lines.  Iida S, Shimada J, Sakagami H.  In Vivo  2013  27(3):321-32  PubMed ID: 23606687
5110  Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.  Ohno H, Araho D, Uesawa Y, Kagaya H, Ishihara M, Sakagami H, Yamamoto M.  Anticancer Res  2013  33(8):3061-8  PubMed ID: 23898061
5057  Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.  Tsujikawa T, Yaguchi T, Ohmura G, Ohta S, Kobayashi A, Kawamura N, Fujita T, Nakano H, Shimada T, Takahashi T, Nakao R, Yanagisawa A, Hisa Y, Kawakami Y.  Int J Cancer.  2013  132(12):2755-66  PubMed ID: 23180648
5028  ALY as a potential contributor to metastasis in human oral squamous cell carcinoma.  Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  J Cancer Res Clin Oncol  2013  139(4):585-94  PubMed ID: 23242234
6067  High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer.  Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K.  Int J Oncol  2013  42(1):141-50  PubMed ID: 23123766
6070  Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases.  Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  J Cancer Res Clin Oncol  2013  139(4):533-42  PubMed ID: 23207790
6072  Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis.  Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H.  PLoS One  2013  8(2):e56381  PubMed ID: 23418564
6074  Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer.  Shimizu F1, Shiiba M2, Ogawara K3, Kimura R1, Minakawa Y1, Baba T1, Yokota S, Nakashima D1, Higo M3, Kasamatsu A3, Sakamoto Y3, Tanzawa H4, Uzawa K4.  PLoS One  2013  8(12):e83187  PubMed ID: 24386158
6076  Kinesin family member 4A: a potential predictor for progression of human oral cancer.  Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K.  PLoS One. 2  2013  8(12):e85951  PubMed ID: 24386490
6077  Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma.  Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information  J Oral Pathol Med  2013  42(2):133-9  PubMed ID: 22672247
6078  Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x.  Hotta H, Hamamura K, Yamashita K, Shibuya H, Tokuda N, Hashimoto N, Furukawa K, Yamamoto N, Hattori H, Toyokuni S, Ueda M, Furukawa K.  Glycoconj J  2013  30(6):585-97  PubMed ID: 23242548
6083  EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy.  Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H.  Br J Cancer  2013  109(8):2155-66  PubMed ID: 4045666
6087  Activation-induced cytidine deaminase mRNA expression in oral squamous cell carcinoma-derived cell lines is upregulated by inflammatory cytokines.  Miyazaki Y, Inoue H, Kikuchi K, Ochiai K, Kusama K.  J Oral Sci  2012  54(1):71-5  PubMed ID: 22466889
6088  Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.  Baba T, Kawaguchi M, Fukushima T, Sato Y, Orikawa H, Yorita K, Tanaka H, Lin CY, Sakoda S, Kataoka H.  J Pathol  2012  228(2):181-92  PubMed ID: 22262311
6089  Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  J Oral Sci  2012  54(3):241-50  PubMed ID: 2304703
6094  Analysis of a cancer stem cell marker EpCAM in an oral squamous cell carcinoma cell line as monolayers and multicellular aggregates  Yuichi Ohnishi et al  Journal of Osaka Dental University  2012  46:215-220 
6095  Absence of Dickkopf (Dkk)-3 protein expression is correlated with longer disease-free survival and lower incidence of metastasis in head and neck squamous cell carcinoma.  Katase N, Lefeuvre M, Gunduz M, Gunduz E, Beder LB, Grenman R, Fujii M, Tamamura R, Tsujigiwa H, Nagatsuka H.  Oncol Lett  2012  3(2):273-280  PubMed ID: 22740894
6098  Podoplanin expression during dysplasia-carcinoma sequence in the oral cavity.  Inoue H, Miyazaki Y, Kikuchi K, Yoshida N, Ide F, Ohmori Y, Tomomura A, Sakashita H, Kusama K.  Tumour Biol  2012  33(1):183-94  PubMed ID: 2081310
6109  A novel function of EpCAM in oral squamous cell carcinoma cells under anchorage-independent conditions.  Inoue H, Ohnishi Y, Nakajima M, Kakudo K, Nozaki M.  Int J Oncol  2011  39(6):1401-5  PubMed ID: 21785818
6111  Effect of EpCAM localization on proliferation of an oral squamous cell carcinoma cell line  Hiroshi Inoue, Yuichi Ohnishi, Masahiro Watanabe, Tomoko Fujii, Yuki Minamino, Yoshihide Ugaki, Suguru Dateoka, Mitsuchika Sugitatsu, Masayuki Tsunokuma, Hirohito Kubo, Masahiro Nakajima, Kenji Kakudo  Journal of Osaka Dental UniversityJournal of Osaka Dental University  2011  45:259-264 
6112  Effects of a gamma secretase inhibitor on the proliferation and invasiveness of oral squamous cell carcinoma cell lines  lHiroshi Inoue et al  Asian Journal of Oral and Maxillofacial Surgery   2011  23:1-6 
6116  Gene therapy for oral squamous cell carcinoma with IAI.3B promoter-driven oncolytic adenovirus-infected carrier cells.  Zhang T, Hamada K, Hyodo M, Itoh H, Tani K, Goda H, Nakashiro K, Hamakawa H.  Oncol Rep  2011  25(3):795-802  PubMed ID: 21206983
6118  Synergistic anti-tumor effect of CDDP with CRM197, a specific inhibitor of HB-EGF, in oral cancer  Suguru Dateoka, Yuichi Ohnishi, Kenji Kakudo  Journal of Osaka Dental University  2011  45:31-36 
6120  NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma.  Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K.  Biochem Biophys Res Commun  2010  391(4):1785-91  PubMed ID: 20045673
6122  Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway.  Nomi N, Kodama S, Suzuki M.  Oncol Rep  2010  24(1):225-31  PubMed ID: 20514466
6123  Association of butyric acid produced by periodontopathic bacteria with progression of oral cancer  Yuji Miyazaki et al  J Cancer Sci Ther  2010  2(2) :26-32 
6127  Tumor-specific cytotoxic activity of 1,2,3,4-tetrahydroisoquinoline derivatives against human oral squamous cell carcinoma cell lines.  Hatano H, Takekawa F, Hashimoto K, Ishihara M, Kawase M, Qing C, Qin-Tao W, Sakagami H.  Anticancer Res  2009  29(8):3079-86  PubMed ID: 19661319
6128  Tumor-specific cytotoxicity and type of cell death induced by naphtho[2,3-b]furan-4,9-diones and related compounds in human tumor cell lines: relationship to electronic structure.  Takano A, Hashimoto K, Ogawa M, Koyanagi J, Kurihara T, Wakabayashi H, Kikuchi H, Nakamura Y, Motohashi N, Sakagami H, Yamamoto K, Tanaka A.  Anticancer Res  2009  29(1):455-64  PubMed ID: 19331186
6129  Tumor-specific cytotoxicity and type of cell death induced by benzo[b]cyclohept[e][1,4]oxazine and 2-aminotropone derivatives.  Narita T, Suga A, Kobayashi M, Hashimoto K, Sakagami H, Motohashi N, Kurihara T, Wakabayashi H.  Anticancer Res  2009  29(4):1123-30  PubMed ID: 19414354
6136  Comparative analysis of cell death induction by cisplatin and 5-FU in human oral squamous and hepatocellular carcinoma cell lines.  Okamura M, Shimada J, Sakagami H.  Anticancer Res  2008  28(1A):253-9  PubMed ID: 18383853
6138  Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines.  Murayama H, Miyahara K, Wakabayashi H, Kurihara T, Hashimoto K, Amano O, Kikuchi H, Nakamura Y, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res  2008  28(2A):1069-78 
6140  Antiviral, antibacterial and vitamin C-synergized radical-scavenging activity of Sasa senanensis Rehder extract.  Sakagami H, Amano S, Kikuchi H, Nakamura Y, Kuroshita R, Watanabe S, Satoh K, Hasegawa H, Nomura A, Kanamoto T, Terakubo S, Nakashima H, Taniguchi S, Oizumi T.  In Vivo  2008  2(4):471-6  PubMed ID: 18712174
6141  Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.  Nakamura E, Kozaki K, Tsuda H, Suzuki E, Pimkhaokham A, Yamamoto G, Irie T, Tachikawa T, Amagasa T, Inazawa J, Imoto I.  Cancer Sci  2008  99(7):1390-400  PubMed ID: 18452558
6143  Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines.  Sekine T, Takahashi J, Nishishiro M, Arai A, Wakabayashi H, Kurihara T, Kobayashi M, Hashimoto K, Kikuchi H, Katayama T, Kanda Y, Kunii S, Motohashi N, Sakagami H.  Anticancer Res.  2007  27(1A):133-43  PubMed ID: 17352225
6148  Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines.  Akatsu Y, Ohshima N, Yamagishi Y, Nishishiro M, Wakabayashi H, Kurihara T, Kikuchi H, Katayama T, Motohashi N, Shoji Y, Nakashima H, Sakagami H.  Anticancer Res  2006  26(3A):1917-23  PubMed ID: 16827125
6150  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456
11620  Quantitative Structure-Cytotoxicity Relationship of Azulene Amide Derivatives.  Imanari K, Hashimoto M, Wakabayashi H, Okudaira N, Bandow K, Nagai J, Tomomura M, Tomomura A, Uesawa Y, Sakagami H.  Anticancer Res.  2019    PubMed ID: 31262875
11844  CD36 expression on oral squamous cell carcinoma cells correlates with enhanced proliferation and migratory activity.  Sakurai K, Tomihara K, Yamazaki M, Heshiki W, Moniruzzaman R, Sekido K, Tachinami H, Ikeda A, Imaue S, Fujiwara K, Noguchi M.  Oral Dis  2019    PubMed ID: 31603606



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