細胞番号 : 細胞名
RCB1892 : SKG-IIIa
update : 2023/01/05
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| 細胞特性(Comment:英) | Cervical carcinoma cell line derived from human. TA-4, CA-4, TPA, placental ALP are positive. Regan isoenzyme producing. p53 normal, p51 mutation (+), HLA-A 2402/. TKG0462 (Deposited from Tohoku Univ.). |
| 細胞特性(日) | ヒト子宮頚癌由来細胞株。TA-4, CA-4, TPA, placental ALP 陽性。Regan isoenzyme 産生。p53正常。p51変異あり。HLA-A 2402/。 TKG0462 (東北大学医用細胞資源センターからの寄託)。 |
| 細胞特性(寄託者記述:英) | |
| 細胞特性(寄託者記述:日) | |
| 使用条件(英) | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| 使用条件(日) | 基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。 |
| 備考(英) | |
| 備考(日) | |
| 提供申込書類(英) |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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| 提供申込書類(日) |
依頼書C-0001.pdf
同意書(非営利学術目的)C-0003.pdf
同意書(営利目的)C-0003p.pdf
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提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
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| 提供手数料 |
手数料とお支払いについてはこちらをご覧ください。 |
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細胞基本情報
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寄託者 |
Obinata, Masuo
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| 樹立者 |
Nozawa, S.
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| 寄託日 |
2004
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| 元の細胞 |
TKG0462
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| 動物種 |
_human
< Mammals
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| 属名 |
Homo
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| 種名 |
sapiens
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| 性別 |
Female
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| 採取組織 |
cervix
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| 細胞分類 |
cancer
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| 入手歴 |
Cell Resource Center for Biomedical Research, Tohoku University（TKG0462）
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細胞寿命 |
infinite
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| 細胞形態 |
epithelial-like
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| Cellosaurus(Expasy) |
CVCL_1704
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細胞培養・検査情報
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寄託時情報 |
ロット情報 |
| 培地・試薬情報 |
培地・試薬一覧はこちらをご覧ください。 |
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培養形態 |
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Adherent cells
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| 培地 |
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HamF12 + 10% FBS
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| 抗生物質 |
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Free
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継代方法 |
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0.25% Trypsin
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継代密度 |
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1 : 8 split
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| 継代・培地交換頻度 |
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Subculture : 2 times/week
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| 培養最適温度 |
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37
℃
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| 二酸化炭素濃度 |
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5
%
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| 凍結培地 |
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Medium + 10% DMSO
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| 凍結方法 |
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Slow freezing
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| マイコプラズマ |
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(-)
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| アイソザイム検査 |
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LD, NP
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| 染色体検査 |
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41-83(50) : /41(1),42(3),43(24),44(11),45(9),81(1)/
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| 個体識別検査 |
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OK
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| 文献情報 |
Reference(英) |
11件
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| Reference(日) |
1件
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| 利用者成果(英) |
5件
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| 利用者成果(日) |
0件
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| Reference(英) |
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5009
Takahashi M, Kataoka S, Kobayashi E, Udagawa Y, Aoki D, Oie S, Kozu A, Nozawa S.
Differences in apoptosis induced by anticancer drugs in sublines (SKG-3a, SKG-3b) from a human uterine cervical epidermoid carcinoma.
Oncol Res
1999
11(2):71-5
PubMed ID: 10489162
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2395
Ueda M, Ueki M, Terai Y, Morimoto A, Fujii H, Yoshizawa K, Yanagihara T
Stimulatory effects of EGF and TGF-alpha on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in uterine cervical-carcinoma SKG-IIIb cells.
Int J Cancer
1997
72:1027-33
PubMed ID: 9378537
DOI: 10.1002/(sici)1097-0215(19970917)72:6<1027::aid-ijc18>3.0.co;2-1
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5008
Nozawa S, Kojima M, Tukazaki K, Sakayori M, Iizuka R, Kagiyama N.
In vitro and in vivo induction of squamous cell carcinoma antigen (SCC) in a uterine cervical cancer cell line (SKG-IIIa) with peplomycin and sodium butyrate.
Asia Oceania J Obstet Gynaecol
1990
16(2):153-60
PubMed ID: 1696099
DOI: 10.1111/j.1447-0756.1990.tb00018.x
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5007
Nozawa S, Narisawa S, Takayama Y, Kurihara S, Mukai M.
Production and characterization of monoclonal antibody to uterine cervical cancer cell line SKG-IIIa
Nihon Sanka Fujinka Gakkai Zasshi
1985
37(12):2767-74
PubMed ID: 2418136
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2854
Udagawa Y, Nozawa S, Tsukazaki K, Ohta H, Akiba T, Kurihara S
[Biological properties of two newly established cell lines (SKG-3a,3b) from a human uterine cervical epidermoid carcinoma]
Nippon Sanka Fujinka Gakkai Zasshi
1984
36:237-46
PubMed ID: 6699456
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5006
Nozawa S, Tsai D, Kojima M, Jeng CH, Arai H, Widjaja T, Udagawa Y, Oota H, Kurihara S.
Modulation of alkaline phosphatase by butyrate and prednisolone in uterine cervical cancer cell line (SKG-III)
Nihon Sanka Fujinka Gakkai Zasshi
1984
36(1):57-66
PubMed ID: 6699450
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2852
Nozawa S, Udagawa Y, Ohta H, Kurihara S, Fishman WH
Newly established uterine cervical cancer cell line (SKG-III) with Regan isoenzyme, human chorionic gonadotropin beta-subunit, and pregnancy-specific beta 1-glycoprotein phenotypes.
Cancer Res
1983
43:1748-60
PubMed ID: 6600963
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2853
Nozawa S, Engvall E, Kano S, Kurihara S, Fishman WH
Sodium butyrate produces concordant expression of “early placental” alkaline phosphatase, pregnancy‐specific beta1‐glycoprotein and human chorionic gonadotropin beta‐subunit in a newly established uterine cervical cancer cell line (SKG‐IIIa)
Int J Cancer
1983
32:267-72
PubMed ID: 6604031
DOI: 10.1002/ijc.2910320302
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5462
Nozawa S. et al
A newly established uterine cervical cancer cell line (SKG-3)with Regan isoenzyme, human chorionic gonadotropin beta-subunitand pregnancyspecific betai-glycoprotein phenotypes.
Cancer Res
1983
43:1748
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5476
Udagawa, Y et al
Electron microscopic findings of two newly established cell strains (SKG-3a,3b) from a human uterine cervical epidermoidi carcinoma.
J Clin Electron Microscopy
1980
13:611
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5461
Nozawa S. et al
EIectronmicroscopic findings of a newly established cell line (SKG-3a)ef human uterine cervical cancer.
J Clin Electron Microscopy
1979
12:676
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| 利用者成果(英) |
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19540
Furukawa Y, Ishii M, Ando J, Ikeda K, Igarashi KJ, Kinoshita S, Azusawa Y, Toyota T, Honda T, Nakanishi M, Ohshima K, Masuda A, Yoshida E, Kitade M, Porteus M, Terao Y, Nakauchi H, Ando M.
iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer
Cell Rep Med
2023
4(12):101327
PubMed ID: 38091985
DOI: 10.1016/j.xcrm.2023.101327
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13328
Kagabu M, Yoshino N, Saito T, Miura Y, Takeshita R, Murakami K, Kawamura H, Baba T, Sugiyama T.
The efficacy of a third-generation oncolytic herpes simplex viral therapy for an HPV-related uterine cervical cancer model.
Int J Clin Oncol
2021
26(3):591-597.
PubMed ID: 33146805
DOI: 10.1007/s10147-020-01823-6
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5011
Nagura M, Matsumura N, Baba T, Murakami R, Kharma B, Hamanishi J, Yamaguchi K, Abiko K, Koshiyama M, Mandai M, Murata T, Murphy SK, Konishi I.
Invasion of uterine cervical squamous cell carcinoma cells is facilitated by locoregional interaction with cancer-associated fibroblasts via activating transforming growth factor-beta.
Gynecol Oncol
2015
136(1):104-11
PubMed ID: 25434636
DOI: 10.1016/j.ygyno.2014.11.075
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6390
Kawashima H, Obayashi A, Kawamura M, Masaki S, Tamada S, Iguchi T, Uchida J, Kuratsukuri K, Tanaka T, Nakatani T.
Galectin 9 and PINCH, novel immunotherapy targets of renal cell carcinoma: a rationale to find potential tumour antigens and the resulting cytotoxic T lymphocytes induced by the derived peptides.
BJU Int
2014
113(2):320-32
PubMed ID: 24895689
DOI: 10.1111/bju.12499
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5012
Kawakami T, Chano T, Minami K, Okabe H, Okada Y, Okamoto K.
Imprinted DLK1 is a putative tumor suppressor gene and inactivated by epimutation at the region upstream of GTL2 in human renal cell carcinoma.
Hum Mol Genet
2006
15(6):821-30
PubMed ID: 16439445
DOI: 10.1093/hmg/ddl001
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