Cell No. : Cell Name
RCB1881 : TL-Mor
update : 2024/10/02
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| Comment | BSL2. Human derived T cell line. HTLV-1 pro-virus DNA(+). TKG0369 (Deposited from Tohoku Univ.). Based on the information by depositor; this cell line possesses HTLV-1 pro-virus DNA. We don't know whether virus particles are produced or not. Therefore, the cells must be handled under BSL2. |
| Comment from the depositor | |
| Terms and conditions | There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC. |
| Remarks | |
| Order Form |
Order Form(C-0005.pdf)
MTA(C-0007.pdf)
MTA(C-0007p.pdf)
Cell line to be handled at BSL 2(C-0070.pdf)
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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Basic information
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Depositor |
Obinata, Masuo
|
| Year of deposit |
2004
|
| Original cell |
TKG0369
|
| Animal |
_human
< Mammals
|
| Genus |
Homo
|
| Species |
sapiens
|
| Tissue |
lymphocytes (T cell )
|
| Classification |
cancer
|
| History |
Cell Resource Center for Biomedical Research, Tohoku University（TKG0369）
|
|
Lifespan |
infinite
|
| Morphology |
other
|
| BSL |
BSL2
|
| Cellosaurus(Expasy) |
CVCL_0074
|
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| |
deposit info |
lot info |
|
Medium |
Medium List |
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Culture type |
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Suspension cells
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| Culture method |
|
General Guidelines for Culturing Suspension Cells, 浮遊細胞の培養に関する一般的な注意(Japanese)
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| Culture medium |
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RPMI1640 + 10% FBS
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| Antibiotics |
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Free
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Passage method |
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dilution
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Culture information
|
Passage ratio |
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1 : 8 split
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| SC frequency |
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Subculture : 2 times/week
|
| Temperature |
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37
℃
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| CO2 concentration |
|
5
%
|
| Freeze medium |
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Medium + 10% DMSO
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| Freezing method |
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Slow freezing
|
| Mycoplasma/Acholeplasma |
|
(-)
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| Virus (HIV) |
|
LT 400
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| Virus (HTLV-1) |
|
DNA (+)
|
| Isozyme |
|
LD, NP
|
| Chromosome mode |
|
86-92(50) : /87(4),88(9),89(20),90(10),91(1),92(4)
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| STR(human) |
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OK
|
| Images |
deposit info | lot info |
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| Reference information |
Reference |
3
|
| User's Publication |
4
|
| Reference |
|
4997
Sugamura K, Nakai S, Fujii M, Hinuma Y.
Interleukin 2 inhibits in vitro growth of human T cell lines carrying retrovirus.
J Exp Med
1985
161(5):1243-8
PubMed ID: 2985730
DOI: 10.1084/jem.161.5.1243
|
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4995
Sugamura K, Fujii M, Ueda S, Hinuma Y.
Identification of a glycoprotein, gp21, of adult T cell leukemia virus by monoclonal antibody.
J Immunol
1984
132(6):3180-4
PubMed ID: 6327819
|
|
4996
Sugamura K, Fujii M, Kannagi M, Sakitani M, Takeuchi M, Hinuma Y.
Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus.
Int J Cancer
1984
34(2):221-8
PubMed ID: 6088403
DOI: 10.1002/ijc.2910340213
|
| User's Publication |
|
21989
Sudo H, Tonoyama Y, Ikebe E, Hasegawa H, Iha H, Ishida YI.
Proteomic analysis of adult T-cell leukemia/lymphoma: A biomarker identification strategy based on preparation and in-solution digestion methods of total proteins
Leuk Res
2024
138:107454
PubMed ID: 38452534
DOI: 10.1016/j.leukres.2024.107454
|
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19979
Kurahashi Y, Watanabe T, Yamamoto Y, Ureshino H, Kamachi K, Yoshida-Sakai N, Fukuda-Kurahashi Y, Yamashita S, Hattori N, Nakamura H, Kawaguchi A, Ushijima T, Sueoka E, Kimura S.
Dual targeting of aberrant DNA and histone methylation synergistically suppresses tumor cell growth in ATL
Blood Adv
2023
7(8):1545-1559
PubMed ID: 36516085
DOI: 10.1182/bloodadvances.2022008362
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10693
Tatsuro Watanabe, Satoshi Yamashita, Hiroshi Ureshino, Kazuharu Kamachi, Yuki Kurahashi, Yuki Fukuda-Kurahashi, Nao Yoshida, Naoko Hattori, Hideaki Nakamura, Akemi Sato, Atsushi Kawaguchi, Naoko Sueoka-Aragane, Kensuke Kojima, Seiji Okada, Toshikazu Ushijima, Shinya Kimura, Eisaburo Sueoka
Targeting Aberrant DNA Hypermethylation as a Driver of ATL Leukemogenesis Using the New Oral Demethylating Agent OR-2100
Blood
2020
136(7):871-884
PubMed ID: 32391874
DOI: 10.1182/blood.2019003084
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9736
Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.
TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma.
Oncol Lett
2016
12:1519-1524
PubMed ID: 27446463
DOI: 10.3892/ol.2016.4774
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