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RCB1645 : Y79  update : 2018/07/06
CommentCaucasian retinoblastoma. May have reverse transcriptase. Back up culture of ECA2583.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 2000
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 2.5 years
Tissue eye
Case history retinoblastoma
Classification cancer
History overseas, ECACC -> RIKEN Cell Bank
Lifespan infinite
Morphology other
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Chromosome mode 32-188(18) : /34(1),35(5),37(2),40(1),45(1),46(1)/
deposit info
lot info
Reference information Reference 3
User's Publication 15

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1167  Reid, T W, Albert, D M, Rabson, A S, Russell P, Craft J, Chu, E W, Tralka, T S, Wilcox, J L  Characteristics of an established cell line of retinoblastoma.  J Natl Cancer Inst  1974  53:347-60  PubMed ID: 4135597
4981  McFall RC, Sery TW, Makadon M.  Characterization of a new continuous cell line derived from a human retinoblastoma.  Cancer Res  1977  37(4):1003-10  PubMed ID: 844036
4982  McFall RC, Nagy RM, Nagle BT, McGreevy LM.  Scanning electron microscopic observation of two retinoblastoma cell lines.  Cancer Res  1978  38(9):2827-35  PubMed ID: 679190

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User's Publication
1971  Kato G, Maeda S  Novel phosphorylation at a mitotic site, serine 75, in human pp60c-src from unsynchronized human tumor cells having a spherical morphology.  Biochem Biophys Res Commun  1995  216:619-29  PubMed ID: 7488156
2363  Hayashi N, Ido E, Ohtsuki Y, Ueno H  An experimental application of gene therapy for human retinoblastoma.  Invest Ophthalmol Vis Sci  1999  40:265-72  PubMed ID: 9950583
2660  Hayakawa, Kou, Guo, Lei, Terentyeva, Elena A, Li, Xiao Kang, Kimura, Hiromitsu, Hirano, Masahiko, Yoshikawa, Kazuyuki, Yoshinaga, Teruo, Nagamine, Takeaki, Katsumata, Noriyuki, Tanaka, Toshiaki  Size-exclusion chromatography of biological samples which contain extremely alkaline proteins.  J Biochem Biophys Methods  2003  56:153-63  PubMed ID: 12834974
7342  Venkatesan N, Deepa PR, Khetan V, Krishnakumar S.  Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy.  Bioinform Biol Insights  2015  9:89-101  PubMed ID: 25983556
7685  Saito R, Nakauchi H, Watanabe S.  Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.  Cancer Sci.  2011  103:42-9  PubMed ID: 21923749
7883  Baba Y, Iida A, Watanabe S.  Sall3 plays essential roles in horizontal cell maturation through regulation of neurofilament expression levels.  Biochimie  2011  93:1037-46  PubMed ID: 21396426
8346  Ishikawa Y, Nagai J, Okada Y, Sato K, Yumoto R, Takano M.  Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.  Biol. Pharm. Bull.  2010  33:504-11  PubMed ID: 20190417
8478  Satoh S, Tang K, Iida A, Inoue M, Kodama T, Tsai SY, Tsai MJ, Furuta Y, Watanabe S.  The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors.  J. Neurosci.  2009  29:12401-11  PubMed ID: 19812316
8491  Inoue M, Iida A, Satoh S, Kodama T, Watanabe S.  COUP-TFI and -TFII nuclear receptors are expressed in amacrine cells and play roles in regulating the differentiation of retinal progenitor cells.  Exp. Eye Res.  2009  90:49-56  PubMed ID: 19766631
8620  Mikami-Terao Y, Akiyama M, Yuza Y, Yanagisawa T, Yamada O, Kawano T, Agawa M, Ida H, Yamada H.  Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines.  Exp. Eye Res.  2009  89:200-8  PubMed ID: 19328784
8733  Lin YP, Ouchi Y, Satoh S, Watanabe S.  Sox2 plays a role in the induction of amacrine and Muller glial cells in mouse retinal progenitor cells.  Invest. Ophthalmol. Vis. Sci.  2008  50:68-74  PubMed ID: 18719084
9644  Venkatesan N, Kanwar JR, Deepa PR, Navaneethakrishnan S, Joseph C, Krishnakumar S.  Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma.  Chem. Biol. Interact.  2016  252:141-9  PubMed ID: 27062892
9903  Danda R, Ganapathy K, Sathe G, Madugundu AK, Ramachandran S, Krishnan UM, Khetan V, Rishi P, Keshava Prasad TS, Pandey A, Krishnakumar S, Gowda H, Elchuri SV.  Proteomic profiling of retinoblastoma by high resolution mass spectrometry.  Clin Proteomics  2016  13:29  PubMed ID: 27799869
10610  Kalmodia S, Parameswaran S, Ganapathy K, Yang W, Barrow CJ, Kanwar JR, Roy K, Vasudevan M, Kulkarni K, Elchuri SV, Krishnakumar S.  Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2 Interaction in Retinoblastoma.  Mol Ther Nucleic Acids  2017  9:349-364  PubMed ID: 29246314
10861    Targeting CD44, ABCG2 and CD133 markers using aptamers: in silico analysis of CD133 extracellular domain 2 and its aptamer  RSC Adv.  2016  6, 32115-32123 

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