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RCB1639 : LoVo  update : 2019/12/16
CommentCEA-producing colon adenocarcinoma. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA 87060101 prior to order.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 2000
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 56 years
Tissue colon, supraclavicular meta
Case history colon adenocarcinoma
Metastastatic ability Yes
Metastatsd tissue left supraclavicular
Classification cancer
History overseas, ECACC -> RIKEN Cell Bank
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives HamF12 + 10% FBS
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Isozyme LD, NP
Chromosome mode 49-51(50) : 49(31),50(17),51(2)
deposit info
lot info
Reference information Reference 7
User's Publication 14

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2576  Inhibition of proliferation by c-myb antisense oligodeoxynucleotides in colon adenocarcinoma cell lines that express c-myb.  Melani C, Rivoltini L, Parmiani G, Calabretta B, Colombo, M P  Cancer Res  1991  51:2897-901  PubMed ID: 2032228
2497  Further biologic characteristics of a human carcinoembryonic antigen-producing colon carcinoma cell line.  Drewinko B, Yang, L Y, Barlogie B, Romsdahl M, Meistrich M, Malahy, M A, Giovanella B  J Natl Cancer Inst  1978  61:75-83  PubMed ID: 276641
2496  Restriction of CEA synthesis to the stationary phase of growth of cultured human colon carcinoma cells.  Drewinko B, Yand, L Y  Exp Cell Res  1976  101:414-6  PubMed ID: 964319
2495  Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.  Drewinko B, Romsdahl, M M, Yang, L Y, Ahearn, M J, Trujillo, J M  Cancer Res  1976  36:467-75  PubMed ID: 1260746
2574  Tumour necrosis factor-alpha induces translocation of protein kinase C in tumour necrosis factor-sensitive cell lines.  Matsubara N, Fuchimoto S, Orita K  Immunology  1991  73:457-9  PubMed ID: 1916896
2575  Isolation and characterization of a human colon adenocarcinoma cell line resistant to doxorubicin.  Grandi M, Geroni C, Giuliani, F C  Br J Cancer  1986  54:515-8  PubMed ID: 3756087
4983  Response of exponentially growing, stationary-phase, and synchronized cultured human colon carcinoma cells to treatment with nitrosourea derivatives.  Drewinko B, Barlogie B, Freireich EJ.  Cancer Res  1979  39(7 Pt 1):2630-6  PubMed ID: 445465

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User's Publication
8700  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399
9551  Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress.  Kasai T, Nakanishi T, Ohno Y, Shimada H, Nakamura Y, Arakawa H, Tamai I.  Exp. Cell Res.  2016  341:123-31  PubMed ID: 26850138
9637  A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells.  Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M.  Exp. Cell Res.  2016  343:177-189  PubMed ID: 27032575
10185  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773
10296  Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer.  Gombodorj N, Yokobori T, Yoshiyama S, Kawabata-Iwakawa R, Rokudai S, Horikoshi I, Nishiyama M, Nakano T.  Anticancer Res.  2017  37:2425-2436  PubMed ID: 28476810
10498  Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.  Inaguma S, Lasota J, Felisiak-Golabek A, Kowalik A, Wang Z, Zieba S, Kalisz J, Ikeda H, Miettinen M.  J Pathol Clin Res  2017  3:268-278  PubMed ID: 29085667
10501  5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice.  Kushibiki T, Noji T, Ebihara Y, Hontani K, Ono M, Kuwabara S, Nakamura T, Tsuchikawa T, Okamura K, Ishizuka M, Hirano S.  In Vivo  2017  31:905-908  PubMed ID: 28882957
11009  Evidence suggesting sphingosine 1-phosphate may be actively generated, degraded and transported to extracellular spaces with increased S1P2 and S1P3 expressions in colon cancer    Clinical Colorectal Cancer  2018  17, e171-e182  PubMed ID: 29223361
5452  Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells.  Abe N, Hou DX, Munemasa S, Murata Y, Nakamura Y.  Cell Death Dis  2014  5:e1534  PubMed ID: 25412312
3752  Analysis of tissue factor and tissue factor pathway inhibitor expression in human colorectal carcinoma cell lines and metastatic sublines to the liver.  Kataoka H, Uchino H, Asada Y, Hatakeyama K, Nabeshima K, Sumiyoshi A, Koono M.  Int J Cancer  1997  72(5):878-84  PubMed ID: 9311608
3754  Hepatocyte growth factor/scatter factor induces not only scattering but also cohort migration of human colorectal-adenocarcinoma cells.  Nabeshima K, Shimao Y, Inoue T, Itoh H, Kataoka H, Koono M.  Int J Cancer  1998  78(6):750-9  PubMed ID: 9833769
3764  Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo.  Uchino H, Kataoka H, Itoh H, Hamasuna R, Koono M.  Gastroenterology  2000  118(1):60-9  PubMed ID: 10611154
3771  DNA amplification and chromosomal translocations are accompanied by chromosomal instability: analysis of seven human colon cancer cell lines by comparative genomic hybridization and spectral karyotyping.  Tsushimi T, Noshima S, Oga A, Esato K, Sasaki K.  Cancer Genet Cytogenet  2001  126(1):34-8  PubMed ID: 11343776
6410  Is parainfluenza virus a threatening virus for human cancer cell lines?  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309

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