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RCB1637 : 293  update : 2019/10/24
細胞特性(Comment:英)Sheared human Ad5 DNA-transformed cell line. Widely used for production of manipulated adenovirus. Back up culture of ECA2737. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to the website of ECACC prior to order.
細胞特性(日)ヒト胎児腎細胞由来、アデノウイルス5型による形質転換株、HEK293細胞ともいう。ECACC由来(ECA2737)株。ご購入前に、ECACCのウェブサイトを必ずご参照ください。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)Basically, there is no restriction regarding academic use.
使用条件(日)学術研究における利用につきましては原則として使用制限はありません。
備考(英)
備考(日)
提供申込書類 依頼書C-0001.pdf   同意書(非営利)C-0003.pdf   同意書(営利)C-0003p.pdf  
提供同意書は、使用機関及び使用内容に応じて二種類あります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は別途ご相談(cellbank.brc@riken.jp)を承ります。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 ECACC
寄託日 2000
別名 HEK293
動物種 human < Mammals
属名 Homo
種名 sapiens
embryo
採取組織 kidney
細胞分類 transformed
入手歴 overseas, ECACC -> Riken cell bank
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS + 0.1mM NEAA
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP
染色体検査 63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 3件
Reference(日) 0件
利用者成果(英) 93件
利用者成果(日) 0件

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Reference(英)
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304
4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220

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Reference(日)

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利用者成果(英)
3431  Sugihara, Eiji, Kanai, Masayuki, Saito, Soichiro, Nitta, Takayuki, Toyoshima, Hideo, Nakayama, Keiko, Nakayama, Keiichi I, Fukasawa, Kenji, Schwab, Manfred, Saya, Hideyuki, Miwa, Masanao  Suppression of centrosome amplification after DNA damage depends on p27 accumulation.  Cancer Res  2006  66:4020-9  PubMed ID: 16618721
2993  Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M  Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.  J Biol Chem  2005  280:28044-52  PubMed ID: 15927955
3350  Nagayoshi, Ryusaku, Nagai, Taku, Matsushita, Kakushi, Sato, Katsuaki, Sunahara, Nobuhiko, Matsuda, Takemasa, Nakamura, Tadashi, Komiya, Setsuro, Onda, Masanori, Matsuyama, Takami  Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages.  Arthritis Rheum  2005  52:2666-75  PubMed ID: 16142741
7018  Uchida S, Yoshinaga N, Yanagihara K, Yuba E, Kataoka K, Itaka K.  Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination.  Biomaterials  2018  150:162-170  PubMed ID: 29031816
7056  Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.  Forward-genetics analysis of sleep in randomly mutagenized mice.  Nature  2016  539:378-383  PubMed ID: 27806374
7127  Mimura Y, Kelly RM, Unwin L, Albrecht S, Jefferis R, Goodall M, Mizukami Y, Mimura-Kimura Y, Matsumoto T, Ueoka H, Rudd PM.  Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.  J. Immunol. Methods  2015  428:30-6  PubMed ID: 26627984
7128  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.  Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.  J Pharm Pharm Sci  2015  18:316-27  PubMed ID: 26626238
7150  Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K.  PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.  Biochem. J.  2015  473:257-66  PubMed ID: 26574435
7210  Shimizu S, Yonezawa R, Negoro T, Yamamoto S, Numata T, Ishii M, Mori Y, Toda T.  Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.  Int. J. Biochem. Cell Biol.  2015  68:119-27  PubMed ID: 26386353
7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247
7244  Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.  Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.  Nat Commun  2015  6:8021  PubMed ID: 26282514
7289  Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C.  Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.  PLoS Negl Trop Dis  2015  9:e0003914  PubMed ID: 26162094
7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659
7319  Kato T, Yui M, Deo VK, Park EY.  Development of Rous sarcoma Virus-like Particles Displaying hCC49 scFv for Specific Targeted Drug Delivery to Human Colon Carcinoma Cells.  Pharm. Res.  2015  32:3699-707  PubMed ID: 26047779
7426  Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.  Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.  J. Cell. Physiol.  2015  230:2510-21  PubMed ID: 25802132
7438  Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M.  DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification.  J. Biosci. Bioeng.  2015  120:463-6  PubMed ID: 25772439
7489  Kamada Y, Kusakabe T, Sugimoto Y.  Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals.  Biochim. Biophys. Acta  2015  1850:1107-19  PubMed ID: 25659958
7567  Tamura M, Kunihiro S, Hamashima Y, Yoshioka Y, Tone S, Kameda K.  An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells.  Biotechnology Reports  2015  6:45-50 
7658  Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, Katsumata Y, Yoneda Y, Yamanaka H.  NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus.  Arthritis Rheum.  2011  63:3952-9  PubMed ID: 22012858
7731  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.  J Control Release  2011  156:195-202  PubMed ID: 21802461
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973
7833  Watanabe M, Itoh K.  Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1.  Biochim. Biophys. Acta  2011  1814:900-7  PubMed ID: 21545853
7891  Okano I, Miyazato M, Kangawa K.  A guanosine 3',5'-cyclic monophosphate (cGMP) reporter system based on the G-kinase/CREB/CRE signal transduction pathway.  Biochem. Biophys. Res. Commun.  2011  407:236-41  PubMed ID: 21382339
7914  Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, Iwata T, Takahashi M.  Modeling retinal degeneration using patient-specific induced pluripotent stem cells.  PLoS ONE  2011  6:e17084  PubMed ID: 21347327
8001  Ohtani M, Miyadai T.  Functional analysis of fish BCL-6 and Blimp-1 in vitro: transcriptional repressors for B-cell terminal differentiation in fugu (Takifugu rubripes).  Mol. Immunol.  2011  48:818-25  PubMed ID: 21216469
8047  Kohno M, Horibe T, Haramoto M, Yano Y, Ohara K, Nakajima O, Matsuzaki K, Kawakami K.  A novel hybrid peptide targeting EGFR-expressing cancers.  Eur. J. Cancer  2010  47:773-83  PubMed ID: 21112771
8059  Sugimoto M, Sasaki S, Watanabe T, Nishimura S, Ideta A, Yamazaki M, Matsuda K, Yuzaki M, Sakimura K, Aoyagi Y, Sugimoto Y.  Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate.  PLoS ONE  2010  5:e13817  PubMed ID: 21072200
8070  Hashimoto O, Yonezawa T, Sugiyama Y, Kawaminami M, Hasegawa Y.  Molecular cloning and expression of canine prolactin gene.  Exp. Anim.  2010  59:643-6  PubMed ID: 21030793
8100  Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T.  Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.  PLoS ONE  2010  5:  PubMed ID: 20927330
8126  Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H.  Salicylate restores transport function and anion exchanger activity of missense pendrin mutations.  Hear. Res.  2010  270:110-8  PubMed ID: 20826203
8133  Fukumori R, Takarada T, Nakamichi N, Kambe Y, Kawagoe H, Nakazato R, Yoneda Y.  Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria.  Neurochem. Int.  2010  57:730-7  PubMed ID: 20813147
8160  Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M.  Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.  J. Nat. Prod.  2010  73:1332-6  PubMed ID: 20695472
8244  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.  Bioconjug. Chem.  2010  21:1087-95  PubMed ID: 20499901
8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766
8323  Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N.  Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.  Biochem. Biophys. Res. Commun.  2010  394:153-7  PubMed ID: 20193664
8447  Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M.  Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.  J. Cell. Physiol.  2009  222:481-7  PubMed ID: 19937979
8487  Ishii M, Kobayashi S, Ohkura M, Yamamoto R, Shimizu S, Kiuchi Y.  Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.  J. Pharmacol. Sci.  2009  111:221-5  PubMed ID: 19783864
8531  Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K.  Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse.  Biol. Reprod.  2009  81:889-97  PubMed ID: 19605790
8536  Munekata K, Sakamoto K.  Forkhead transcription factor Foxo1 is essential for adipocyte differentiation.  In Vitro Cell. Dev. Biol. Anim.  2009  45:642-51  PubMed ID: 19585174
8571  Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T.  A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.  Clin. Cancer Res.  2009  15:3725-32  PubMed ID: 19458054
8573  Takarada T, Takahata Y, Iemata M, Hinoi E, Uno K, Hirai T, Yamamoto T, Yoneda Y.  Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.  J. Cell. Physiol.  2009  220:756-64  PubMed ID: 19452450
8574  Takarada T, Hojo H, Iemata M, Sahara K, Kodama A, Nakamura N, Hinoi E, Yoneda Y.  Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.  Bone  2009  45:568-78  PubMed ID: 19446054
8614  Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y.  Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.  Toxicol. Appl. Pharmacol.  2009  237:232-6  PubMed ID: 19341753
8616  Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M.  Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.  Biol. Pharm. Bull.  2009  32:564-72  PubMed ID: 19336885
8631  Uehara Y, Mochizuki M, Matsuno K, Haino T, Asai A.  Novel high-throughput screening system for identifying STAT3-SH2 antagonists.  Biochem. Biophys. Res. Commun.  2009  380:627-31  PubMed ID: 19285012
8690  Okamura H, Amorim BR, Wang J, Yoshida K, Haneji T.  Calcineurin regulates phosphorylation status of transcription factor osterix.  Biochem. Biophys. Res. Commun.  2008  379:440-4  PubMed ID: 19114031
8877  Kubo Y, Akiyama M, Fukada Y, Okano T.  Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.  J. Neurochem.  2006  97:1155-65  PubMed ID: 16686694
8903  Matsui K, Horiuchi S, Sando S, Sera T, Aoyama Y.  RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity.  Bioconjug. Chem.  2006  17:132-8  PubMed ID: 16417261
9358  Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M.  Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.  In Vitro Cell. Dev. Biol. Anim.  2003  39:80-8  PubMed ID: 12892531
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
9703  Toda T, Yamamoto S, Yonezawa R, Mori Y, Shimizu S.  Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.  Eur. J. Pharmacol.  2016  786:19-28  PubMed ID: 27238971
9708  Tohno M, Shinkai H, Toki D, Okumura N, Tajima K, Uenishi H.  Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin.  Immunogenetics  2016  68:693-701  PubMed ID: 27236661
9882  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020
9982  Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, Ito Y, Yamaguchi M, Yamazaki Y, Ikari A.  Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.  J. Cell. Physiol.  2017  232:2841-2850  PubMed ID: 27925186
9983  Imaizumi Y, Goda T, Schaffhauser DF, Okada JI, Matsumoto A, Miyahara Y.  Proton-sensing transistor systems for detecting ion leakage from plasma membranes under chemical stimuli.  Acta Biomater  2017  50:502-509  PubMed ID: 27956364
10079  Satou K, Mochimaru Y, Nakakura T, Kusada T, Negishi J, Musha S, Yoshimura N, Kato Y, Tomura H.  Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase.  J. Reprod. Dev.  2017  63:199-204  PubMed ID: 28090002
10393  Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K.  Genetic basis of calcifying cystic odontogenic tumors.  PLoS ONE  2017  12:e0180224  PubMed ID: 28658279
10416  Kubota Y, Fujioka K, Takekawa M.  WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins.  PLoS ONE  2017  12:e0180714  PubMed ID: 28686627
10433  Endo-Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, Makishima M.  1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators.  J. Steroid Biochem. Mol. Biol.  2017  172:136-148  PubMed ID: 28736297
10524  Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y.  L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.  JCI Insight  2017  2:  PubMed ID: 28931752
10620  Nakamura M, Fujita K, Toyoda Y, Takada T, Hasegawa H, Ichida K.  Investigation of the transport of xanthine dehydrogenase inhibitors by the urate transporter ABCG2.  Drug Metab. Pharmacokinet.  2018  33:77-81  PubMed ID: 29342419
10917    One-pot Synthesis of Water Soluble Highly Fluorescent Silica Nanoparticles  J. Mater. Chem. B  2017  5, 1363--1370  
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018    PubMed ID: 29763296
11083  Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M.  Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.  Nat Commun  2018    PubMed ID: 29799007
11158  Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K.  Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.  Nucleic Acids Res.  2018    PubMed ID: 30085309
11074  Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, Matsumoto Y, Nochi T, Watanabe K, Aso H, Tomioka Y.  Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation.  J. Biol. Chem.  2018    PubMed ID: 29760187
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018    PubMed ID: 30101880
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033
11268  Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.  Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.  Cell Rep  2018    PubMed ID: 30380411
11312  Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.  Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.  J. Cell. Physiol.  2019    PubMed ID: 30461012
11399  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Yuyama K, Nakamura H, Fu Q, Maehara O, Suda G, Sakamoto N.  Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.  Stem Cells Int  2018    PubMed ID: 30675167
11394  Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H.  Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.  Cell Metab.  2019    PubMed ID: 30661929
11402  Morita M, Hashimoto O.  Identification and expression of the medaka inhibin βE subunit.  Mol. Biol. Rep.  2019    PubMed ID: 30680594
11412  Zhang W, Matsuo R, Takahara T, Shibata H, Maki M.  High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins.  Methods Mol. Biol.  2019    PubMed ID: 30710293
11411  Zhang W, Takahara T, Achiha T, Shibata H, Maki M.  Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.  Methods Mol. Biol.  2019    PubMed ID: 30710269
4085    Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy  bioRxiv  2018   
4101  Takagi M, Kimura K, Nakashima KI, Inoue M.  Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.  Eur. J. Pharmacol.  2018    PubMed ID: 29248425
4102  Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H.  Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.  PLoS ONE  2018    PubMed ID: 30500824
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