Search
CELL BANK Website

Back Back
RCB1637 : 293  update : 2019/12/16
CommentSheared human Ad5 DNA-transformed cell line. Widely used for production of manipulated adenovirus. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA 85120602 prior to order.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ECA85120602 prior to order.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor ECACC
Year of deposit 2000
Another name HEK293
Animal human < Mammals
Genus Homo
Species sapiens
Age at sampling embryo
Tissue kidney
Classification transformed
History overseas, ECACC -> Riken cell bank
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives MEM + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Isozyme LD, NP
Chromosome mode 63-71(50) : /65(5),66(5),67(8),68(10),69(10),70(8)/
Reference information Reference 3
User's Publication 120


To topTop
Reference
4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304

To topTop
User's Publication
9190  Rui Jiang, Ziyan Zhang, Zhiwei Zhong, Yuxuan Dai, Guangyao Liu, Chao Zhang  Phosphorylation of Histone H4 at Serine 1 Is Associated With GCN5 and Mediates Autophagy in Osteosarcoma Bone Cell Lines  J Cell Physiol   2020    PubMed ID: 31903552
9863  Naomi Matsumoto, Reina Matsukawa, Shohei Takahashi, Koshi Kudo, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui  V-ATPase a3 Isoform Mutations Identified in Osteopetrosis Patients Abolish Its Expression and Disrupt Osteoclast Function  Exp Cell Res  2020  389(2):111901  PubMed ID: 32045577
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549
11312  Manabe A, Furukawa C, Hasegawa H, Matsunaga T, Endo S, Ikari A.  Upregulation of transient receptor potential melastatin 6 channel expression by rosiglitazone and all-trans-retinoic acid in erlotinib-treated renal tubular epithelial cells.  J. Cell. Physiol.  2019    PubMed ID: 30461012
11394  Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H.  Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging.  Cell Metab.  2019    PubMed ID: 30661929
11402  Morita M, Hashimoto O.  Identification and expression of the medaka inhibin βE subunit.  Mol. Biol. Rep.  2019    PubMed ID: 30680594
11412  Zhang W, Matsuo R, Takahara T, Shibata H, Maki M.  High Sensitive Quantitative Binding Assays Using a Nanoluciferase-Fused Probe for Analysis of ALG-2-Interacting Proteins.  Methods Mol. Biol.  2019    PubMed ID: 30710293
11411  Zhang W, Takahara T, Achiha T, Shibata H, Maki M.  Cellular Ca2+-Responding Nanoluciferase Reporter Gene System Directed by Tandemly Repeated Pseudo-palindromic NFAT-Response Elements.  Methods Mol. Biol.  2019    PubMed ID: 30710269
6050  Yokota S, Kuramochi H, Okubo K, Iwaya A, Tsuchiya S, Ichiki T.  Extracellular vesicles nanoarray technology: Immobilization of individual extracellular vesicles on nanopatterned polyethylene glycol-lipid conjugate brushes.  PLoS One  2019  14(10):e0224091  PubMed ID: 31648253
11580  Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.  Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.  Exp. Cell Res.  2019    PubMed ID: 31153924
11586  Ikeda Y, Morita SY, Hatano R, Tsuji T, Terada T.  Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux.  Biochim Biophys Acta Mol Cell Biol Lipids  2019    PubMed ID: 31176036
11628  Mitsui E, Yoshida S, Shinoda Y, Matsumori Y, Tsujii H, Tsuchida M, Wada S, Hasegawa M, Ito A, Mino K, Onuki T, Yoshida M, Sasaki R, Mizukami T.  Identification of ryuvidine as a KDM5A inhibitor.  Sci Rep  2019    PubMed ID: 31289306
11800  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Sci Rep  2019    PubMed ID: 31520002
6899  Miyano K, Shiraishi S, Minami, Sudo Y, Suzuki M, Yokoyama T, Terawaki K, Nonaka M, Murata H, Higami Y, Uezono Y.  Carboplatin Enhances the Activity of Human Transient Receptor Potential Ankyrin 1 through the Cyclic AMP-Protein Kinase A-A-Kinase Anchoring Protein (AKAP) Pathways.  Int J Mol Sci  2019  20(13):3271.  PubMed ID: 31277262
6937  Ryo Muko et al  Cloning and Detection of Equine Histidine-Rich Glycoprotein  Journal of Equine Veterinary Science  2019  73:121-126 
7018  Uchida S, Yoshinaga N, Yanagihara K, Yuba E, Kataoka K, Itaka K.  Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination.  Biomaterials  2018  150:162-170  PubMed ID: 29031816
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781
10620  Nakamura M, Fujita K, Toyoda Y, Takada T, Hasegawa H, Ichida K.  Investigation of the transport of xanthine dehydrogenase inhibitors by the urate transporter ABCG2.  Drug Metab. Pharmacokinet.  2018  33:77-81  PubMed ID: 29342419
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296
11083  Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M.  Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.  Nat Commun  2018  9(1):2049  PubMed ID: 29799007
11158  Matsumoto S, Caliskan N, Rodnina MV, Murata A, Nakatani K.  Small synthetic molecule-stabilized RNA pseudoknot as an activator for -1 ribosomal frameshifting.  Nucleic Acids Res.  2018  46(16):8079-8089  PubMed ID: 30085309
11074  Tsukamoto H, Takeuchi S, Kubota K, Kobayashi Y, Kozakai S, Ukai I, Shichiku A, Okubo M, Numasaki M, Kanemitsu Y, Matsumoto Y, Nochi T, Watanabe K, Aso H, Tomioka Y.  Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKK?-IRF3 axis activation.  J. Biol. Chem.  2018  293(26):10186-10201  PubMed ID: 29760187
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880
11260  Fujita D, Arai T, Komori H, Shirasaki Y, Wakayama T, Nakanishi T, Tamai I.  Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells.  Mol. Pharm.  2018    PubMed ID: 30359033
11268  Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A.  Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.  Cell Rep  2018    PubMed ID: 30380411
11399  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Yuyama K, Nakamura H, Fu Q, Maehara O, Suda G, Sakamoto N.  Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats.  Stem Cells Int  2018    PubMed ID: 30675167
4085    Genome-wide silencing screen in mesothelioma cells reveals that loss of function of BAP1 induces chemoresistance to ribonucleotide reductase inhibition: implication for therapy  bioRxiv  2018   
4101  Takagi M, Kimura K, Nakashima KI, Inoue M.  Ameliorative effect of panaxynol on the reduction in high-molecular-weight adiponectin secretion from 3T3-L1 adipocytes treated with palmitic acids.  Eur. J. Pharmacol.  2018    PubMed ID: 29248425
4102  Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H.  Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.  PLoS ONE  2018    PubMed ID: 30500824
4103  Ohara M, Ohnishi S, Hosono H, Yamamoto K, Fu Q, Maehara O, Suda G, Sakamoto N.  Palmitoylethanolamide Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis in Rats.  Front Pharmacol  2018    PubMed ID: 30057547
4104  Mizuno H, Taketomi A.  MicroRNA-101 inhibits the expression of Rhes, a striatal-enriched small G-protein, at the post-transcriptional level in vitro.  BMC Res Notes  2018    PubMed ID: 30064488
4105  Takayama-Ito M, Lim CK, Yamaguchi Y, Posadas-Herrera G, Kato H, Iizuka I, Islam MT, Morimoto K, Saijo M.  Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge.  PLoS Negl Trop Dis  2018    PubMed ID: 29659579
4106  Saifullah, Tsukahara T.  Genotyping of single nucleotide polymorphisms using the SNP-RFLP method.  Biosci Trends  2018    PubMed ID: 30012914
4107  Nishiyama Y, Fujii S, Makishima M, Hashimoto Y, Ishikawa M.  Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.  Int J Mol Sci  2018    PubMed ID: 30021999
4108  Matsuura M, Ohshima M, Hiruta Y, Nishimura T, Nagase K, Kanazawa H.  LAT1-Targeting Thermoresponsive Fluorescent Polymer Probes for Cancer Cell Imaging.  Int J Mol Sci  2018    PubMed ID: 29865203
9982  Furukawa C, Fujii N, Manabe A, Matsunaga T, Endo S, Hasegawa H, Ito Y, Yamaguchi M, Yamazaki Y, Ikari A.  Up-Regulation of Transient Receptor Potential Melastatin 6 Channel Expression by Tumor Necrosis Factor-α in the Presence of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.  J. Cell. Physiol.  2017  232:2841-2850  PubMed ID: 27925186
9983  Imaizumi Y, Goda T, Schaffhauser DF, Okada JI, Matsumoto A, Miyahara Y.  Proton-sensing transistor systems for detecting ion leakage from plasma membranes under chemical stimuli.  Acta Biomater  2017  50:502-509  PubMed ID: 27956364
10079  Satou K, Mochimaru Y, Nakakura T, Kusada T, Negishi J, Musha S, Yoshimura N, Kato Y, Tomura H.  Easy detection of hormone secretion from LβT2 cells by using Gaussia luciferase.  J. Reprod. Dev.  2017  63:199-204  PubMed ID: 28090002
10393  Yukimori A, Oikawa Y, Morita KI, Nguyen CTK, Harada H, Yamaguchi S, Kayamori K, Yamaguchi A, Ikeda T, Sakamoto K.  Genetic basis of calcifying cystic odontogenic tumors.  PLoS ONE  2017  12:e0180224  PubMed ID: 28658279
10416  Kubota Y, Fujioka K, Takekawa M.  WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins.  PLoS ONE  2017  12:e0180714  PubMed ID: 28686627
10433  Endo-Umeda K, Aoyama A, Shimizu M, Ishikawa M, Hashimoto Y, Yamada S, Makishima M.  1α-Hydroxy derivatives of 7-dehydrocholesterol are selective liver X receptor modulators.  J. Steroid Biochem. Mol. Biol.  2017  172:136-148  PubMed ID: 28736297
10524  Masukawa D, Koga M, Sezaki A, Nakao Y, Kamikubo Y, Hashimoto T, Okuyama-Oki Y, Aladeokin AC, Nakamura F, Yokoyama U, Wakui H, Ichinose H, Sakurai T, Umemura S, Tamura K, Ishikawa Y, Goshima Y.  L-DOPA sensitizes vasomotor tone by modulating the vascular alpha1-adrenergic receptor.  JCI Insight  2017  2:  PubMed ID: 28931752
10917    One-pot Synthesis of Water Soluble Highly Fluorescent Silica Nanoparticles  J. Mater. Chem. B  2017  5, 1363--1370  
7056  Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M.  Forward-genetics analysis of sleep in randomly mutagenized mice.  Nature  2016  539:378-383  PubMed ID: 27806374
7062  Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, Kunieda T.  Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein.  Nat Commun  2016  7:12808  PubMed ID: 27649274
9703  Toda T, Yamamoto S, Yonezawa R, Mori Y, Shimizu S.  Inhibitory effects of Tyrphostin AG-related compounds on oxidative stress-sensitive transient receptor potential channel activation.  Eur. J. Pharmacol.  2016  786:19-28  PubMed ID: 27238971
9708  Tohno M, Shinkai H, Toki D, Okumura N, Tajima K, Uenishi H.  Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin.  Immunogenetics  2016  68:693-701  PubMed ID: 27236661
9882  Moriwaki S, Into T, Suzuki K, Miyauchi M, Takata T, Shibayama K, Niida S.  γ-Glutamyltranspeptidase is an endogenous activator of Toll-like receptor 4-mediated osteoclastogenesis.  Sci Rep  2016  6:35930  PubMed ID: 27775020
8922  Kashima H, Momose F, Umehara H, Miyoshi N, Ogo N, Muraoka D, Shiku H, Harada N, Asai A.  Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity.  PLoS One  2016  11(6):e0156643  PubMed ID: 27284967
7127  Mimura Y, Kelly RM, Unwin L, Albrecht S, Jefferis R, Goodall M, Mizukami Y, Mimura-Kimura Y, Matsumoto T, Ueoka H, Rudd PM.  Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines.  J. Immunol. Methods  2015  428:30-6  PubMed ID: 26627984
7128  Sato Y, Sasaki T, Takahashi S, Kumagai T, Nagata K.  Development of a highly reproducible system to evaluate inhibition of cytochrome P450 3A4 activity by natural medicines.  J Pharm Pharm Sci  2015  18:316-27  PubMed ID: 26626238
7150  Shizu R, Abe T, Benoki S, Takahashi M, Kodama S, Miayata M, Matsuzawa A, Yoshinari K.  PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor.  Biochem. J.  2015  473:257-66  PubMed ID: 26574435
7210  Shimizu S, Yonezawa R, Negoro T, Yamamoto S, Numata T, Ishii M, Mori Y, Toda T.  Sensitization of H2O2-induced TRPM2 activation and subsequent interleukin-8 (CXCL8) production by intracellular Fe(2+) in human monocytic U937 cells.  Int. J. Biochem. Cell Biol.  2015  68:119-27  PubMed ID: 26386353
7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247
7244  Ishii T, Sato K, Kakumoto T, Miura S, Touhara K, Takeuchi S, Nakata T.  Light generation of intracellular Ca(2+) signals by a genetically encoded protein BACCS.  Nat Commun  2015  6:8021  PubMed ID: 26282514
7289  Miura R, Kooriyama T, Yoneda M, Takenaka A, Doki M, Goto Y, Sanjoba C, Endo Y, Fujiyuki T, Sugai A, Tsukiyama-Kohara K, Matsumoto Y, Sato H, Kai C.  Efficacy of Recombinant Canine Distemper Virus Expressing Leishmania Antigen against Leishmania Challenge in Dogs.  PLoS Negl Trop Dis  2015  9:e0003914  PubMed ID: 26162094
7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659
7319  Kato T, Yui M, Deo VK, Park EY.  Development of Rous sarcoma Virus-like Particles Displaying hCC49 scFv for Specific Targeted Drug Delivery to Human Colon Carcinoma Cells.  Pharm. Res.  2015  32:3699-707  PubMed ID: 26047779
7426  Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y.  Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP.  J. Cell. Physiol.  2015  230:2510-21  PubMed ID: 25802132
7438  Ono A, Ito A, Suzuki T, Yamaguchi M, Kawabe Y, Kamihira M.  DNA damage-responsive transgene expression mediated by the p53 promoter with transcriptional amplification.  J. Biosci. Bioeng.  2015  120:463-6  PubMed ID: 25772439
7489  Kamada Y, Kusakabe T, Sugimoto Y.  Amyloidogenic lysozymes accumulate in the endoplasmic reticulum accompanied by the augmentation of ER stress signals.  Biochim. Biophys. Acta  2015  1850:1107-19  PubMed ID: 25659958
7567  Tamura M, Kunihiro S, Hamashima Y, Yoshioka Y, Tone S, Kameda K.  An improved superoxide-generating nanodevice for oxidative stress studies in cultured cells.  Biotechnology Reports  2015  6:45-50 
9407  Michiko Yoshida, Kenji Hata, Rikako Takashima, Koichiro Ono, Eriko Nakamura, Yoshifumi Takahata, Tomohiko Murakami, Sachiko Iseki, Teruko Takano-Yamamoto, Riko Nishimura, Toshiyuki Yoneda  The Transcription Factor Foxc1 Is Necessary for Ihh-Gli2-regulated Endochondral Ossification  Nat Commun  2015  6:6653  PubMed ID: 25808752
9473  Koichi Fujikawa, Ryo Fukumori, Saki Nakamura, Takaya Kutsukake, Takeshi Takarada, Yukio Yoneda  Potential Interactions of Calcium-Sensitive Reagents With Zinc Ion in Different Cultured Cells  PLoS One  2015  10(5):e0127421  PubMed ID: 26010609
6236  Xu H, Shen Z, Xiao J, Yang Y, Huang W, Zhou Z, Shen J, Zhu Y1, Liu XY, Chu L.  Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect.  BMC Cancer  2014  14:668  PubMed ID: 25220382
3443  Shimizu S, Yonezawa R, Hagiwara T, Yoshida T, Takahashi N, Hamano S, Negoro T, Toda T, Wakamori M, Mori Y, Ishii M.  Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca(2+) entry.  Eur J Pharmacol  2014  742:22-30  PubMed ID: 25179574
9113  Mutsuyo Takayama-Ito, Kazuo Nakamichi, Hitomi Kinoshita, Satsuki Kakiuchi, Ichiro Kurane, Masayuki Saijo, Chang-Kweng Lim  A Sensitive in Vitro Assay for the Detection of Residual Viable Rabies Virus in Inactivated Rabies Vaccines  Biologicals  2014  42 (1), 42-7  PubMed ID: 24321529
9475  Kazuhiro Shiozaki, Sena Ryuzono, Naoto Matsushita, Asami Ikeda, Kazuki Takeshita, Petros Kingstone Chigwechokha, Masaharu Komatsu, Taeko Miyagi  Molecular Cloning and Biochemical Characterization of Medaka (Oryzias Latipes) Lysosomal neu4 Sialidase  Fish Physiol Biochemc  2014  40(5):1461-72  PubMed ID: 24744226
9478  Petros Kingstone Chigwechokha, Masaharu Komatsu, Takao Itakura, Kazuhiro Shiozaki  Nile Tilapia Neu3 Sialidases: Molecular Cloning, Functional Characterization and Expression in Oreochromis Niloticus  Gene  2014  552(1):155-64  PubMed ID: 25234733
4392  Shiozaki K, Takeshita K, Ikeda M, Ikeda A, Harasaki Y, Komatsu M, Yamada S, Yamaguchi K, Miyagi T.  Molecular cloning and biochemical characterization of two novel Neu3 sialidases, neu3a and neu3b, from medaka (Oryzias latipes).  Biochimie  2013  95(2):280-9  PubMed ID: 23032629
9099  Syed Ahmed, Jinhua Dong, Megumi Yui, Tatsuya Kato, Jaebeom Lee, Enoch Y Park  Quantum Dots Incorporated Magnetic Nanoparticles for Imaging Colon Carcinoma Cells  J Nanobiotechnology  2013  11, 28  PubMed ID: 23957878
6313  Shen J, Maruyama IN.  Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells.  J Mol Signal  2012  7(1):2  PubMed ID: 22269274
7658  Gono T, Takarada T, Fukumori R, Kawaguchi Y, Kaneko H, Hanaoka M, Katsumata Y, Yoneda Y, Yamanaka H.  NR2-reactive antibody decreases cell viability through augmentation of Ca(2+) influx in systemic lupus erythematosus.  Arthritis Rheum.  2011  63:3952-9  PubMed ID: 22012858
7731  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.  J Control Release  2011  156:195-202  PubMed ID: 21802461
7817  Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N.  Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.  FEBS Lett.  2011  585:1741-7  PubMed ID: 21570973
7833  Watanabe M, Itoh K.  Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1.  Biochim. Biophys. Acta  2011  1814:900-7  PubMed ID: 21545853
7891  Okano I, Miyazato M, Kangawa K.  A guanosine 3',5'-cyclic monophosphate (cGMP) reporter system based on the G-kinase/CREB/CRE signal transduction pathway.  Biochem. Biophys. Res. Commun.  2011  407:236-41  PubMed ID: 21382339
7914  Jin ZB, Okamoto S, Osakada F, Homma K, Assawachananont J, Hirami Y, Iwata T, Takahashi M.  Modeling retinal degeneration using patient-specific induced pluripotent stem cells.  PLoS ONE  2011  6:e17084  PubMed ID: 21347327
8001  Ohtani M, Miyadai T.  Functional analysis of fish BCL-6 and Blimp-1 in vitro: transcriptional repressors for B-cell terminal differentiation in fugu (Takifugu rubripes).  Mol. Immunol.  2011  48:818-25  PubMed ID: 21216469
3516  Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S.  Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines.  BMC Mol Biol  2011  12:31  PubMed ID: 21771320
8047  Kohno M, Horibe T, Haramoto M, Yano Y, Ohara K, Nakajima O, Matsuzaki K, Kawakami K.  A novel hybrid peptide targeting EGFR-expressing cancers.  Eur. J. Cancer  2010  47:773-83  PubMed ID: 21112771
8059  Sugimoto M, Sasaki S, Watanabe T, Nishimura S, Ideta A, Yamazaki M, Matsuda K, Yuzaki M, Sakimura K, Aoyagi Y, Sugimoto Y.  Ionotropic glutamate receptor AMPA 1 is associated with ovulation rate.  PLoS ONE  2010  5:e13817  PubMed ID: 21072200
8070  Hashimoto O, Yonezawa T, Sugiyama Y, Kawaminami M, Hasegawa Y.  Molecular cloning and expression of canine prolactin gene.  Exp. Anim.  2010  59:643-6  PubMed ID: 21030793
8100  Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T.  Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.  PLoS ONE  2010  5:  PubMed ID: 20927330
8126  Ishihara K, Okuyama S, Kumano S, Iida K, Hamana H, Murakoshi M, Kobayashi T, Usami S, Ikeda K, Haga Y, Tsumoto K, Nakamura H, Hirasawa N, Wada H.  Salicylate restores transport function and anion exchanger activity of missense pendrin mutations.  Hear. Res.  2010  270:110-8  PubMed ID: 20826203
8133  Fukumori R, Takarada T, Nakamichi N, Kambe Y, Kawagoe H, Nakazato R, Yoneda Y.  Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria.  Neurochem. Int.  2010  57:730-7  PubMed ID: 20813147
8160  Kotani H, Tanabe H, Mizukami H, Makishima M, Inoue M.  Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.  J. Nat. Prod.  2010  73:1332-6  PubMed ID: 20695472
8244  Chang KL, Higuchi Y, Kawakami S, Yamashita F, Hashida M.  Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.  Bioconjug. Chem.  2010  21:1087-95  PubMed ID: 20499901
8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766
8323  Feng GG, Li C, Huang L, Tsunekawa K, Sato Y, Fujiwara Y, Komatsu T, Honda T, Fan JH, Goto H, Koide T, Hasegawa T, Ishikawa N.  Naofen, a novel WD40-repeat protein, mediates spontaneous and tumor necrosis factor-induced apoptosis.  Biochem. Biophys. Res. Commun.  2010  394:153-7  PubMed ID: 20193664
5869  Tatsuya Nodagashira,Hiroki Odagiri,Shojiro-Kazunori Ikenaga,Masaki Maruyama, Toshiyuki Sato and Kenichi Hakamada  Efficient gene transduction in HER2-expressing cancer cells by two recombinant adenovirus vectors with HER2 promoter and Cre/loxP system  Hirosaki Med J  2010  61:26―34 
9483  Kazunori Yamaguchi, Koichi Koseki, Momo Shiozaki, Yukiko Shimada, Tadashi Wada, Taeko Miyagi  Regulation of Plasma-Membrane-Associated Sialidase NEU3 Gene by Sp1/Sp3 Transcription Factors  Biochem J   2010  430(1):107-17  PubMed ID: 20518744
8447  Ikari A, Sanada A, Okude C, Sawada H, Yamazaki Y, Sugatani J, Miwa M.  Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells.  J. Cell. Physiol.  2009  222:481-7  PubMed ID: 19937979
8487  Ishii M, Kobayashi S, Ohkura M, Yamamoto R, Shimizu S, Kiuchi Y.  Inhibitory effect of lomerizine, a prophylactic drug for migraines, on serotonin-induced contraction of the basilar artery.  J. Pharmacol. Sci.  2009  111:221-5  PubMed ID: 19783864
8531  Yamatoya K, Yoshida K, Ito C, Maekawa M, Yanagida M, Takamori K, Ogawa H, Araki Y, Miyado K, Toyama Y, Toshimori K.  Equatorin: identification and characterization of the epitope of the MN9 antibody in the mouse.  Biol. Reprod.  2009  81:889-97  PubMed ID: 19605790
8536  Munekata K, Sakamoto K.  Forkhead transcription factor Foxo1 is essential for adipocyte differentiation.  In Vitro Cell. Dev. Biol. Anim.  2009  45:642-51  PubMed ID: 19585174
8571  Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T.  A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.  Clin. Cancer Res.  2009  15:3725-32  PubMed ID: 19458054
8573  Takarada T, Takahata Y, Iemata M, Hinoi E, Uno K, Hirai T, Yamamoto T, Yoneda Y.  Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes.  J. Cell. Physiol.  2009  220:756-64  PubMed ID: 19452450
8574  Takarada T, Hojo H, Iemata M, Sahara K, Kodama A, Nakamura N, Hinoi E, Yoneda Y.  Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.  Bone  2009  45:568-78  PubMed ID: 19446054
8614  Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y.  Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes.  Toxicol. Appl. Pharmacol.  2009  237:232-6  PubMed ID: 19341753
8616  Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M.  Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.  Biol. Pharm. Bull.  2009  32:564-72  PubMed ID: 19336885
8631  Uehara Y, Mochizuki M, Matsuno K, Haino T, Asai A.  Novel high-throughput screening system for identifying STAT3-SH2 antagonists.  Biochem. Biophys. Res. Commun.  2009  380:627-31  PubMed ID: 19285012
8690  Okamura H, Amorim BR, Wang J, Yoshida K, Haneji T.  Calcineurin regulates phosphorylation status of transcription factor osterix.  Biochem. Biophys. Res. Commun.  2008  379:440-4  PubMed ID: 19114031
4714  Sakurai M, Misawa T, Shiba H, Iida T, Ohashi T, Yanaga K.  A novel approach for gene transduction with adenovirus vector and the fibrin glue system.  Anticancer Res  2008  28(6A):3809-13  PubMed ID: 19189668
3438  Kira Y1, Nishikawa M.  The identification and characterization of a new GTP-binding protein (Gbp45) involved in cell proliferation and death related to mitochondrial function.  Cell Mol Biol Lett  2008  13(4):570-84  PubMed ID: 18536999
6519  Hata K, Nishimura R, Muramatsu S, Matsuda A, Matsubara T, Amano K, Ikeda F, Harley VR, Yoneda T.  Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice.  J Clin Invest  2008  118(9):3098-108  PubMed ID: 18677406
5983  Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T.  Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23).  Genes Chromosomes Cancer  2007  46(9):813-9  PubMed ID: 17551948
3431  Sugihara, Eiji, Kanai, Masayuki, Saito, Soichiro, Nitta, Takayuki, Toyoshima, Hideo, Nakayama, Keiko, Nakayama, Keiichi I, Fukasawa, Kenji, Schwab, Manfred, Saya, Hideyuki, Miwa, Masanao  Suppression of centrosome amplification after DNA damage depends on p27 accumulation.  Cancer Res  2006  66:4020-9  PubMed ID: 16618721
8877  Kubo Y, Akiyama M, Fukada Y, Okano T.  Molecular cloning, mRNA expression, and immunocytochemical localization of a putative blue-light photoreceptor CRY4 in the chicken pineal gland.  J. Neurochem.  2006  97:1155-65  PubMed ID: 16686694
8903  Matsui K, Horiuchi S, Sando S, Sera T, Aoyama Y.  RNAi silencing of exogenous and endogenous reporter genes using a macrocyclic octaamine as a "compact" siRNA carrier. Studies on the nonsilenced residual activity.  Bioconjug. Chem.  2006  17:132-8  PubMed ID: 16417261
6448  Takeuchi T, Adachi Y, Sonobe H, Furihata M, Ohtsuki Y.  A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion.  Oncogene  2006  25(53):7059-69  PubMed ID: 16715130
2993  Ikeno Y, Konno N, Cheon SH, Bolchi A, Ottonello S, Kitamoto K, Arioka M  Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.  J Biol Chem  2005  280:28044-52  PubMed ID: 15927955
3350  Nagayoshi, Ryusaku, Nagai, Taku, Matsushita, Kakushi, Sato, Katsuaki, Sunahara, Nobuhiko, Matsuda, Takemasa, Nakamura, Tadashi, Komiya, Setsuro, Onda, Masanori, Matsuyama, Takami  Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages.  Arthritis Rheum  2005  52:2666-75  PubMed ID: 16142741
3349  Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M.  A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells.  J Biol Chem  2005  280(47):39284-93  PubMed ID: 16135517
2515  Sugiura T, Nagano Y, Inoue T, Hirotani K.  A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma.  Biochem Biophys Res Commun  2004  315(1):204-11  PubMed ID: 15013446
9358  Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, Kurimoto M.  Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.  In Vitro Cell. Dev. Biol. Anim.  2003  39:80-8  PubMed ID: 12892531
3593  Matsuguchi T, Masuda A, Sugimoto K, Nagai Y, Yoshikai Y.  JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation.  EMBO J  2003  22(17):4455-64  PubMed ID: 12941697
9040  Byoung-Hee Lee, Kumiko Yoshimatsu, Akihiko Maeda, Kazuhiko Ochiai, Masami Morimatsu, Koichi Araki, Michiko Ogino, Shigeru Morikawa, Jiro Arikawa  Association of the Nucleocapsid Protein of the Seoul and Hantaan Hantaviruses With Small Ubiquitin-Like modifier-1-related Molecules  Virus Res  2003  98 (1), 83-91  PubMed ID: 14609633
3532  Murakami M, Kambe T, Shimbara S, Kudo I.  Functional coupling between various phospholipase A2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways.  J Biol Chem  1999  274(5):3103-15  PubMed ID: 9915849
3526  Murakami M, Shimbara S, Kambe T, Kuwata H, Winstead MV, Tischfield JA, Kudo I.  The functions of five distinct mammalian phospholipase A2S in regulating arachidonic acid release. Type IIa and type V secretory phospholipase A2S are functionally redundant and act in concert with cytosolic phospholipase A2.  J Biol Chem  1998  273(23):14411-23  PubMed ID: 9603953



Back Back Return Top Page