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19811
Une S, Nakata R, Nonaka K, Akiyama J.
Antiproliferative and anti-inflammatory effects of fractionated crude lectins from boiled kidney beans (Phaseolus vulgaris)
J Food Sci
2024
89(1):671-683
PubMed ID: 37983860
DOI: 10.1111/1750-3841.16847
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21616
Sakuda T, Oda A, Furuta T, Johan MP, Sakaguchi T, Adachi N.
Synergistic VSV Virotherapy and Carbon Nanotube Photothermal Therapy for Osteosarcoma in Murine Models.
Anticancer Res
2024
44(1):99-105
PubMed ID: 38159977
DOI: 10.21873/anticanres.16792
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21875
Ota Y, Inagaki R, Nagai Y, Hirose Y, Murata M, Yamamoto S.
TLR7 agonist, DSP-0509, with radiation combination therapy enhances anti-tumor activity and modulates T cell dependent immune activation.
BMC Immunol
2024
25(1):48
PubMed ID: 39054418
DOI: 10.1186/s12865-024-00643-x
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22318
Ju M, Minami K, Katsuki S, Takenaka W, Tatekawa S, Tamari K, Koizumi M, Takahashi Y, Ogawa K.
Synergistic Effects of Melatonin on Radiosensitization in Carbon-ion Radiotherapy
Anticancer Res
2024
44(8):3295-3306
PubMed ID: 39060064
DOI: 10.21873/anticanres.17148
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19664
Nakamura K, Asanuma K, Okamoto T, Iino T, Hagi T, Nakamura T, Sudo A.
Combination of Everolimus and Bortezomib Inhibits the Growth and Metastasis of Bone and Soft Tissue Sarcomas via JNK/p38/ERK MAPK and AKT Pathways
Cancers (Basel)
2023
15(9):2468
PubMed ID: 37173935
DOI: 10.3390/cancers15092468
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19728
Quartieri M, Puspitasari A, Vitacchio T, Durante M, Tinganelli W.
The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
Front Cell Dev Biol
2023
11:1222809
PubMed ID: 38033871
DOI: 10.3389/fcell.2023.1222809
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19823
Nishimura E, Fukuda K, Matsuda S, Kobayashi R, Matsui K, Takeuchi M, Okubo K, Hirahashi J, Nakamura R, Kawakubo H, Kitagawa Y.
Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration
Surg Today
2023
53(8):973-983
PubMed ID: 36592222
DOI: 10.1007/s00595-022-02637-x
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21083
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N.
Oncolytic Effect of a Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA in an Osteosarcoma Mouse Model.
Anticancer Res
2023
43(3):1185-1191
PubMed ID: 36854523
DOI: 10.21873/anticanres.16264
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21134
Li Y, Katayama Y, Nie I, Nakano T, Sawaragi E, Sakamoto M, Yamanaka H, Tsuge I, Demura S, Yamada Y, Tsuchiya H, Morimoto N.
Development of a novel regenerative therapy for malignant bone tumors using an autograft containing tumor inactivated by high hydrostatic pressurization (HHP).
Regen Ther
2023
22:224-231
PubMed ID: 36923268
DOI: 10.1016/j.reth.2023.02.002
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16215
Manami Suzuki-Karasaki, Takashi Ando, Yushi Ochiai, Kenta Kawahara, Miki Suzuki-Karasaki, Hideki Nakayama, Yoshihiro Suzuki-Karasaki
Air Plasma-Activated Medium Evokes a Death-Associated Perinuclear Mitochondrial Clustering
Int J Mol Sci
2022
23(3):1124
PubMed ID: 35163042
DOI: 10.3390/ijms23031124
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16237
Inoue M, Horiuchi K, Susa M, Taguchi E, Ishizaka T, Rikitake H, Matsuhashi Y, Chiba K.
Trabectedin suppresses osteosarcoma pulmonary metastasis in a mouse tumor xenograft model
J Orthop Res
2022
May 31
PubMed ID: 34057747
DOI: 10.1002/jor.25105
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20656
Ogiwara Y, Nakagawa M, Nakatani F, Uemura Y, Zhang R, Kudo-Saito C.
Blocking FSTL1 boosts NK immunity in treatment of osteosarcoma.
Cancer Lett
2022
537:215690
PubMed ID: 35439537
DOI: 10.1016/j.canlet.2022.215690
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18103
Helm A, Tinganelli W, Simoniello P, Kurosawa F, Fournier C, Shimokawa T, Durante M.
Reduction of Lung Metastases in a Mouse Osteosarcoma Model Treated With Carbon Ions and Immune Checkpoint Inhibitors
Int J Radiat Oncol Biol Phys
2021
109(2):594-602
PubMed ID: 32980497
DOI: 10.1016/j.ijrobp.2020.09.041
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18214
Yurtsever A, Yoshida T, Badami Behjat A, Araki Y, Hanayama R, Fukuma T.
Structural and mechanical characteristics of exosomes from osteosarcoma cells explored by 3D-atomic force microscopy
Nanoscale
2021
13(13):6661-6677
PubMed ID: 33885545
DOI: 10.1039/d0nr09178b
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20032
Lin L, Wang H, Guo W, He E, Huang K, Zhao Q.
Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss.
Cell Signal
2021
82:109935
PubMed ID: 33529755
DOI: 10.1016/j.cellsig.2021.109935
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13630
Hennessy M, Wahba A, Felix K, Cabrera M, Segura MG, Kundra V, Ravoori MK, Stewart J, Kleinerman ES, Jensen VB, Gopalakrishnan V, Pena R, Quach P, Kim G, Kivimäe S, Madakamutil L, Overwijk WW, Zalevsky J, Gordon N.
Bempegaldesleukin (BEMPEG; NKTR-214) efficacy as a single agent and in combination with checkpoint-inhibitor therapy in mouse models of osteosarcoma
Int J Cancer
2021
148(8):1928-1937
PubMed ID: 33152115
DOI: 10.1002/ijc.33382
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14340
Fujiwara T, Yakoub MA, Chandler A, Christ AB, Yang G, Ouerfelli O, Rajasekhar VK, Yoshida A, Kondo H, Hata T, Tazawa H, Dogan Y, Moore MAS, Fujiwara T, Ozaki T, Purdue E, Healey JH.
CSF-1/CSF-1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-Cell Infiltration in the Sarcoma Microenvironment
Mol Cancer Ther
2021
PubMed ID: 34088832
DOI: 10.1158/1535-7163.MCT-20-0591
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14344
Araki Y, Aiba H, Yoshida T, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Igarashi K, Nguyen TD, Ishii KA, Nojima T, Takahashi S, Murakami H, Tsuchiya H, Hanayama R.
Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p
Front Oncol
2021
11:667109.
PubMed ID: 34017686
DOI: 10.3389/fonc.2021.667109
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15140
Matsusaka K, Fujiwara Y, Pan C, Esumi S, Saito Y, Bi J, Nakamura Y, Mukunoki A, Takeo T, Nakagata N, Yoshii D, Fukuda R, Nagasaki T, Tanaka R, Komori H, Maeda H, Watanabe H, Tamada K, Komohara Y, Maruyama T.
α1-acid glycoprotein enhances the immunosuppressive and protumor functions of tumor-associated macrophages
Cancer Res
2021
canres.3471.2020
PubMed ID: 34210751
DOI: 10.1158/0008-5472.CAN-20-3471
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20267
Maruyama K, Okada T, Ueha T, Isohashi K, Ikeda H, Kanai Y, Sasaki K, Gentsu T, Ueshima E, Sofue K, Nogami M, Yamaguchi M, Sugimoto K, Sakai Y, Hatazawa J, Murakami T.
In vivo evaluation of percutaneous carbon dioxide treatment for improving intratumoral hypoxia using 18F-fluoromisonidazole PET-CT.
Oncol Lett
2021
21(3):207
PubMed ID: 33574946
DOI: 10.3892/ol.2021.12468
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20272
Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.
Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.
Sci Rep
2021
11(1):13471
PubMed ID: 34188113
DOI: 10.1038/s41598-021-92860-2
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16104
Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Tsukanishi T, Ohtori S, Yonemoto T.
The Thioredoxin Reductase Inhibitor Auranofin Suppresses Pulmonary Metastasis of Osteosarcoma, But Not Local Progression
Anticancer Res
2021
41(10):4947-4955
PubMed ID: 34593442
DOI: 10.21873/anticanres.15308
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16109
Kinoshita H, Shimozato O, Ishii T, Kamoda H, Hagiwara Y, Ohtori S, Yonemoto T.
The Thioredoxin-1 Inhibitor, PX-12, Suppresses Local Osteosarcoma Progression
Anticancer Res
2021
41(12):6013-6021
PubMed ID: 34848455
DOI: 10.21873/anticanres.15420
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16389
Ideta H, Yoshida K, Okamoto M, Sasaki J, Kito M, Aoki K, Yoshimura Y, Suzuki S, Tanaka A, Takazawa A, Haniu H, Uemura T, Takizawa T, Sobajima A, Kamanaka T, Takahashi J, Kato H, Saito N.
Antitumor Effect of Sclerostin against Osteosarcoma
Cancers (Basel)
2021
13(23):6015
PubMed ID: 34885123
DOI: 10.3390/cancers13236015
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16865
Ando T, Suzuki-Karasaki M, Suzuki-Karasaki M, Ichikawa J, Ochiai T, Yoshida Y, Haro H, Suzuki-Karasaki Y.
Combined Anticancer Effect of Plasma-Activated Infusion and Salinomycin by Targeting Autophagy and Mitochondrial Morphology
Front Oncol
2021
11:593127
PubMed ID: 34150606
DOI: 10.3389/fonc.2021.593127
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11888
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
BMC Cancer
2020
20(1):25.
PubMed ID: 31914969
DOI: 10.1186/s12885-019-6499-y
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11888
Yoshida K, Okamoto M, Sasaki J, Kuroda C, Ishida H, Ueda K, Ideta H, Kamanaka T, Sobajima A, Takizawa T, Tanaka M, Aoki K, Uemura T, Kato H, Haniu H, Saito N.
Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells.
BMC Cancer
2020
20(1):25.
PubMed ID: 31914969
DOI: 10.1186/s12885-019-6499-y
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12049
Yahiro K, Matsumoto Y, Yamada H, Endo M, Setsu N, Fujiwara T, Nakagawa M, Kimura A, Shimada E, Okada S, Oda Y, Nakashima Y.
Activation of TLR4 signaling inhibits progression of osteosarcoma by stimulating CD8-positive cytotoxic lymphocytes.
Cancer Immunol. Immunother.
2020
PubMed ID: 32047957
DOI: 10.1007/s00262-020-02508-9
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13305
Wang X, Xue J, Ma B, Wu J, Chang J, Gelinsky M, Wu C.
Black Bioceramics: Combining Regeneration with Therapy.
Adv Mater
2020
PubMed ID: 33094493
DOI: 10.1002/adma.202005140
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13306
Ando T, Ichikawa J, Fujimaki T, Taniguchi N, Takayama Y, Haro H.
Gemcitabine and Rapamycin Exhibit Additive Effect against Osteosarcoma by Targeting Autophagy and Apoptosis.
Cancers (Basel)
2020
PubMed ID: 33114161
DOI: 10.3390/cancers12113097
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13310
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Adachi N.
Development of an Oncolytic Recombinant Vesicular Stomatitis Virus Encoding a Tumor-suppressor MicroRNA.
Anticancer Res
2020
PubMed ID: 33109569
DOI: 10.21873/anticanres.14652
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13532
Pan C, Fujiwara Y, Horlad H, Shiraishi D, Iriki T, Tsuboki J, Ikeda T, Komohara Y.
Flavonoid Compounds Contained in Epimedii Herba Inhibit Tumor Progression by Suppressing STAT3 Activation in the Tumor Microenvironment
Front Pharmacol
2020
11:262
PubMed ID: 32256354
DOI: 10.3389/fphar.2020.00262
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14872
Ma L, Sakamoto Y, Kanai A, Otsuka H, Takahashi A, Kakimi K, Imai T, Shimokawa T.
Characterization of a Novel Murine Colon Carcinoma Subline with High-Metastatic Activity Established by In Vivo Selection Method
J Mol Sci
2020
21(8):2829
PubMed ID: 32325684
DOI: 10.3390/ijms21082829
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15141
Takenaka W, Takahashi Y, Tamari K, Minami K, Katsuki S, Seo Y, Isohashi F, Koizumi M, Ogawa K.
Radiation Dose Escalation is Crucial in Anti-CTLA-4 Antibody Therapy to Enhance Local and Distant Antitumor Effect in Murine Osteosarcoma
Cancers (Basel)
2020
12(6):1546
PubMed ID: 32545427
DOI: 10.3390/cancers12061546
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12504
Takahashi Y, Yasui T, Minami K, Tamari K, Hayashi K, Otani K, Seo Y, Isohashi F, Koizumi M, Ogawa K.
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma
Oncotarget
2019
10(6):633-646
PubMed ID: 30774761
DOI: 10.18632/oncotarget.26551
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12505
Sakuda T, Kubo T, Johan MP, Furuta T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
Novel Near-Infrared Fluorescence-Guided Surgery With Vesicular Stomatitis Virus for Complete Surgical Resection of Osteosarcomas in Mice
J Orthop Res
2019
37(5):1192-1201
PubMed ID: 30839125
DOI: 10.1002/jor.24277
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11337
Takahashi A, Wakihata S, Ma L, Adachi T, Hirose H, Yoshida Y, Ohira Y.
Temporary Loading Prevents Cancer Progression and Immune Organ Atrophy Induced by Hind-Limb Unloading in Mice.
Int J Mol Sci
2018
PubMed ID: 30544854
DOI: 10.3390/ijms19123959
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4277
Shimizu T, Fuchimoto Y, Okita H, Fukuda K, Kitagawa Y, Ueno S, Kuroda T.
A curative treatment strategy using tumor debulking surgery combined with immune checkpoint inhibitors for advanced pediatric solid tumors: An in vivo study using a murine model of osteosarcoma.
J. Pediatr. Surg.
2018
PubMed ID: 30266483
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4278
Johan MP, Kubo T, Furuta T, Sakuda T, Sakaguchi T, Nakanishi M, Ochi M, Adachi N.
Metastatic tumor cells detection and anti-metastatic potential with vesicular stomatitis virus in immunocompetent murine model of osteosarcoma.
J. Orthop. Res.
2018
PubMed ID: 29637599
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9465
Tomohiko Tokunaga, Takashi Ando, Miki Suzuki-Karasaki, Tomohisa Ito, Asuka Onoe-Takahashi, Toyoko Ochiai, Masayoshi Soma , Yoshihiro Suzuki-Karasaki
Plasma-stimulated Medium Kills TRAIL-resistant Human Malignant Cells by Promoting Caspase-Independent Cell Death via Membrane Potential and Calcium Dynamics Modulation
Int J Oncol
2018
52(3):697-708
PubMed ID: 29393427
DOI: 10.3892/ijo.2018.4251
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14821
Shiraishi D, Fujiwara Y, Horlad H, Saito Y, Iriki T, Tsuboki J, Cheng P, Nakagata N, Mizuta H, Bekki H, Nakashima Y, Oda Y, Takeya M, Komohara Y.
CD163 Is Required for Protumoral Activation of Macrophages in Human and Murine Sarcoma
Cancer Res
2018
78(12):3255-3266
PubMed ID: 29610117
DOI: 10.1158/0008-5472.CAN-17-2011
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10239
Kidani T, Yasuda R, Miyawaki J, Oshima Y, Miura H, Masuno H.
Bisphenol A Inhibits Cell Proliferation and Reduces the Motile Potential of Murine LM8 Osteosarcoma Cells.
Anticancer Res.
2017
37:1711-1722
PubMed ID: 28373433
DOI: 10.21873/anticanres.11503
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10496
Shimizu T, Fuchimoto Y, Fukuda K, Okita H, Kitagawa Y, Kuroda T.
The effect of immune checkpoint inhibitors on lung metastases of osteosarcoma.
J. Pediatr. Surg.
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52:2047-2050
PubMed ID: 28954696
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14705
Tsuda Y, Tanikawa C, Miyamoto T, Hirata M, Yodsurang V, Zhang YZ, Imoto S, Yamaguchi R, Miyano S, Takayanagi H, Kawano H, Nakagawa H, Tanaka S, Matsuda K.
Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells
Sci Rep
2017
7(1):10739
PubMed ID: 28878391
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14753
Takahashi Y, Yasui T, Minami K, Tamari K, Otani K, Seo Y, Isohashi F, Koizumi M, Ogawa K.
Radiation Enhances the Efficacy of Antitumor Immunotherapy with an Immunocomplex of Interleukin-2 and Its Monoclonal Antibody
Anticancer Res
2017
37(12):6799-6806
PubMed ID: 29187458
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9693
Xing Y, Tian Y, Kurosawa T, Matsui S, Touma M, Yanai T, Wu Q, Sugimoto K.
CCL11-induced eosinophils inhibit the formation of blood vessels and cause tumor necrosis.
Genes Cells
2016
21:624-38
PubMed ID: 27169545
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9750
Fujiwara Y, Horlad H, Shiraishi D, Tsuboki J, Kudo R, Ikeda T, Nohara T, Takeya M, Komohara Y.
Onionin A, a sulfur-containing compound isolated from onions, impairs tumor development and lung metastasis by inhibiting the protumoral and immunosuppressive functions of myeloid cells.
Mol Nutr Food Res
2016
60:2467-2480
PubMed ID: 27393711
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Yang D, Okamura H, Morimoto H, Teramachi J, Haneji T.
Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells.
Lab. Invest.
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Kazuyuki Itoh
Basic Research for Osteosarcoma Lung Metastasis (LM8)
Osteosarcoma
2016
19-29
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Dovedi SJ, Adlard AL, Ota Y, Murata M, Sugaru E, Koga-Yamakawa E, Eguchi K, Hirose Y, Yamamoto S, Umehara H, Honeychurch J, Cheadle EJ, Hughes G, Jewsbury PJ, Wilkinson RW, Stratford IJ, Illidge TM.
Intravenous administration of the selective toll-like receptor 7 agonist DSR-29133 leads to anti-tumor efficacy in murine solid tumor models which can be potentiated by combination with fractionated radiotherapy
Oncotarget
2016
7(13):17035-46
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Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H.
Dendritic cells combined with doxorubicin induces immunogenic cell death and exhibits antitumor effects for osteosarcoma
Oncol Lett
2016
11(3):2169-2175
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Kato S, Mori S, Kodama T.
A Novel Treatment Method for Lymph Node Metastasis Using a Lymphatic Drug Delivery System with Nano/Microbubbles and Ultrasound.
J Cancer
2015
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Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H.
Dendritic cells combined with anti-GITR antibody produce antitumor effects in osteosarcoma.
Oncol. Rep.
2015
34:1995-2001
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Nakata H, Miyazaki T, Iwasaki T, Nakamura A, Kidani T, Sakayama K, Masumoto J, Miura H.
Development of tumor-specific caffeine-potentiated chemotherapy using a novel drug delivery system with Span 80 nano-vesicles.
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Fujiwara Y, Shiraishi D, Yoshitomi M, Ikeda T, Mizuta H, Takeya M, Komohara Y
Soyasapogenols contained in soybeans suppress tumour progression by regulating macrophage differentiation into the protumoural phenotype.
J Functional Foods
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Igarashi K, Yamamoto N, Hayashi K, Takeuchi A, Miwa S, Odani A, Tsuchiya H.
Effectiveness of two novel anionic and cationic platinum complexes in the treatment of osteosarcoma
Anticancer Agents Med Chem
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15(3):390-9
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Kawano M, Itonaga I, Iwasaki T, Tsumura H.
Enhancement of antitumor immunity by combining anti-cytotoxic T lymphocyte antigen-4 antibodies and cryotreated tumor lysate-pulsed dendritic cells in murine osteosarcoma
Oncol Rep
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Kawano M, Itonaga I, Iwasaki T, Tsuchiya H, Tsumura H.
Anti-TGF-β antibody combined with dendritic cells produce antitumor effects in osteosarcoma
Clin Orthop Relat Res
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No effects of pulsed electromagnetic fields on expression of cell adhesion molecules (integrin, CD44) and matrix metalloproteinase-2/9 in osteosarcoma cell lines.
Bioelectromagnetics
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Tsubaki M, Yamazoe Y, Yanae M, Satou T, Itoh T, Kaneko J, Kidera Y, Moriyama K, Nishida S.
Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma.
Cytokine
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The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis.
Cancer Res.
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Evidence of involvement of the receptor for advanced glycation end-products (RAGE) in the adhesion of Helicobacter pylori to gastric epithelial cells.
Microbes Infect
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Cryoimmunologic antitumor effects enhanced by dendritic cells in osteosarcoma.
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Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcoma
Oncol Rep
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22(5):1045-50
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Kamei S, Sakayama K, Tamashiro S, Aizawa J, Miyawaki J, Miyazaki T, Yamamoto H, Norimatsu Y, Masuno H.
Ketoprofen in topical formulation decreases the matrix metalloproteinase-2 expression and pulmonary metastatic incidence in nude mice with osteosarcoma.
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Gemcitabine inhibits viability, growth, and metastasis of osteosarcoma cell lines.
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