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RCB1440 : ATN-1  update : 2018/07/06
CommentAdult T-cell leukemia. HTLV-1 pro-virus DNA(+).
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor Naoe, Tomoki
Originator Naoe, Tomoki
Year of deposit 1998
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 47 years
Tissue blood
Classification cancer
Year of origin 1982
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS + 0.1mM NEAA
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 5 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR (human) OK
Virus (HIV) LT 400
Virus (HTLV-1) DNA (+)
Isozyme LD, NP
Chromosome mode 83-89(50) : /84(5),85(8),86(17),87(13),88(4),89(1)
deposit info
lot info
Reference information Reference 1
User's Publication 5

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2349  Cytogenetic characterization of a T-cell line, ATN-1, derived from adult T-cell leukemia cells.  Naoe T, Akao Y, Yamada K, Utsumi, K R, Koike K, Shamoto M, Koie K, Kurosawa Y, Kato K, Abe M, et al.  Cancer Genet Cytogenet  1988  34:77-88  PubMed ID: 3260813

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User's Publication
9736  TIM-3 expression in lymphoma cells predicts chemoresistance in patients with adult T-cell leukemia/lymphoma.  Horlad H, Ohnishi K, Ma C, Fujiwara Y, Niino D, Ohshima K, Jinushi M, Matsuoka M, Takeya M, Komohara Y.  Oncol Lett  2016  12:1519-1524  PubMed ID: 27446463
10269  Cell adhesion molecule-1 (CADM1) expressed on adult T-cell leukemia/lymphoma cells is not involved in the interaction with macrophages.  Komohara Y, Ma C, Yano H, Pan C, Horlad H, Saito Y, Ohnishi K, Fujiwara Y, Okuno Y, Nosaka K, Shimosaki S, Morishita K, Matsuoka M, Wakayama T, Takeya M.  J Clin Exp Hematop  2017  57:15-20  PubMed ID: 28420814
4150  Quantitative Analysis of Interaction Between CADM1 and Its Binding Cell-Surface Proteins Using Surface Plasmon Resonance Imaging.  Ito T, Kasai Y, Kumagai Y, Suzuki D, Ochiai-Noguchi M, Irikura D, Miyake S, Murakami Y.  Front Cell Dev Biol  2018    PubMed ID: 30131958
11579  Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action.  Watanabe M, Sugawara A, Noguchi Y, Hirose T, Ōmura S, Sunazuka T, Horie R.  Eur J Med Chem  2019  178:636-647  PubMed ID: 31226655
6834  Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas.  Yamagishi M et al  Cell Rep  2019  29(8):2321-2337  PubMed ID: 31747604

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