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Cell No. : Cell Name
RCB1189 : THP-1  update : 2024/03/08
CommentHuman cell line derived from acute monocytic leukemia. Differentiate to macrophage-like cells by treatment of phorbol ester. The characteristics are somewhat different from THP-1 distributed from ATCC such as in cell size and drug sensitivities. Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order.Application consideration
Comment from the depositor
Terms and conditions1) There is no restriction regarding use for basic researches. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 16 prior to order. 2) In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor DSMZ
Year of deposit 1995
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 1 year
Tissue peripheral blood
Disease name acute monocytic leukemia
Classification cancer
History overseas, DSMZ (ACC16)
Lifespan infinite
Morphology lymphocyte-like
Cellosaurus(Expasy) CVCL_0006
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Culture medium RPMI1640 + 10% FBS
Culture method
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 8-10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Virus (HIV) Lot.1 : LT 400
Virus (HTLV-1) Lot.1 : (-)
Chromosome mode Lot.1 : 83-94(50) : /88(7), 89(3), 90(6), 91(8), 92(11)/
STR(human) OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 168


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Reference
4951  Tsuchiya S, Minegishi N, Minegishi M, Sato T, Konno T.  Adaptation of a human monocytic leukemia cell line (THP-1) in a protein-free chemically defined medium.  Tohoku J Exp Med  1986  150(4):455-65  PubMed ID: 3551191   DOI: 10.1620/tjem.150.455
4950  Tajima S, Hayashi R, Tsuchiya S, Miyake Y, Yamamoto A.  Cells of a human monocytic leukemia cell line (THP-1) synthesize and secrete apolipoprotein E and lipoprotein lipase.  Biochem Biophys Res Commun  1985  126(1):526-31  PubMed ID: 3855620   DOI: 10.1016/0006-291x(85)90637-0
4949  Tsuchiya S, Kobayashi Y, Goto Y, Okumura H, Nakae S, Konno T, Tada K.  Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.  Cancer Res  1982  42(4):1530-6  PubMed ID: 6949641  
720  Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T, Tada K.  Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).  Int J Cancer  1980  26(2):171-6  PubMed ID: 6970727   DOI: 10.1002/ijc.2910260208

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User's Publication
21574  Kawakami K, Fukuda T, Toyoda M, Nakao Y, Hayashi C, Watanabe Y, Aoki T, Shinjo T, Iwashita M, Yamashita A, Shida M, Sanui T, Uchiumi T, Nishimura F.  Luteolin Is a Potential Immunomodulating Natural Compound against Pulpal Inflammation.  Biomed Res Int  2024  2024:8864513  PubMed ID: 38304347   DOI: 10.1155/2024/8864513
21592  Ito F, Yanatori I, Kato K, Toyokuni S.  Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models.  STAR Protoc  2024  5(1):102892  PubMed ID: 38363686   DOI: 10.1016/j.xpro.2024.102892
17688  Washisaka T, Tabata Y.  Live Imaging of Monocyte/Macrophage Differentiation with Cationized Gelatin Nanospheres Incorporating a Molecular Beacon  ACS Biomater Sci Eng  2023  Apr 4  PubMed ID: 37014020   DOI: 10.1021/acsbiomaterials.2c01420
19871  Yamada M, Nitta Y, Uehara T, Suzuki H, Miya F, Takenouchi T, Tamura M, Ayabe S, Yoshiki A, Maeno A, Saga Y, Furuse T, Yamada I, Okamoto N, Kosaki K, Sugie A.  Heterozygous loss-of-function DHX9 variants are associated with neurodevelopmental disorders: Human genetic and experimental evidences  Eur J Med Genet  2023  66(8):104804  PubMed ID: 37369308   DOI: 10.1016/j.ejmg.2023.104804
21116  Komuro R, Honda Y, Yanaizu M, Nagahama M, Kino Y.  Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins.  Cells  2023  12(4)  PubMed ID: 36831269   DOI: 10.3390/cells12040602
21363  Unzai T, Washisaka T, Tabata Y.  An artificial silk elastin-like protein modifies the polarization of human macrophages line THP-1.  J Biomater Appl  2023  8853282231192186  PubMed ID: 37494553   DOI: 10.1177/08853282231192186
21394  Egusa K, Shibutani S, Iwata H.  IgG and insulin enhance endocytosis in THP-1 cells via activation of phosphatidylinositol 3-kinase (PI3K).  Biochem Biophys Res Commun  2023  679:160-166  PubMed ID: 37696069   DOI: 10.1016/j.bbrc.2023.09.008
21518  Hirata W, Itatani Y, Masui H, Kawada K, Mizuno R, Yamamoto T, Okamoto T, Ogawa R, Inamoto S, Maekawa H, Okamura R, Kiyasu Y, Hanada K, Okamoto M, Nishikawa Y, Sugimoto N, Tamura T, Hatano E, Sakai Y, Obama K.  Downregulation of osteoprotegerin in colorectal cancer cells promotes liver metastasis via activating tumor-associated macrophage.  Sci Rep  2023  13(1):22217  PubMed ID: 38097649   DOI: 10.1038/s41598-023-49312-w
17691  Ushio S, Wada Y, Nakamura M, Matsumoto D, Hoshika K, Shiromizu S, Iwata N, Esumi S, Kajizono M, Kitamura Y, Sendo T.  Anxiolytic-like effects of hochuekkito in lipopolysaccharide-treated mice involve interleukin-6 inhibition  Front Pharmacol  2022  13:890048  PubMed ID: 36034871   DOI: 10.3389/fphar.2022.890048
20632  Kasai F, Hirayama N, Fukushima M, Kohara A, Nakamura Y.  THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines.  Int J Cancer  2022    PubMed ID: 35373342   DOI: 10.1002/ijc.34019
16920  Ikegami H, Yamasaki K, Ogawa M, Nemoto K, Akata K, Noguchi S, Fukuda K, Kawanami T, Mukae H, Yatera K.  Reduced phagocytic activity of human alveolar macrophages infected with Mycobacterium avium complex  J Infect Chemother  2022  Aug 1  PubMed ID: 35926765   DOI: 10.1016/j.jiac.2022.07.018
16971  Kawase A, Takashima O, Tanaka S, Shimada H, Iwaki M.  Diclofenac-Induced Cytotoxicity in Direct and Indirect Co-Culture of HepG2 Cells with Differentiated THP-1 Cells  Int J Mol Sci  2022  23(15):8660  PubMed ID: 35955793   DOI: 10.3390/ijms23158660
20842  Tabata A, Matsumoto A, Fujimoto A, Ohkura K, Ikeda T, Oda H, Yokohata S, Kobayashi M, Tomoyasu T, Takao A, Ohkuni H, Nagamune H.  Dual functions of discoidinolysin, a cholesterol-dependent cytolysin with N-terminal discoidin domain produced from Streptococcus mitis strain Nm-76.  J Oral Microbiol  2022  14(1):2105013  PubMed ID: 35937899   DOI: 10.1080/20002297.2022.2105013
20897  Ito M, Maejima Y, Nishimura K, Nakae Y, Ono A, Iwaki-Egawa S.  A role for N-glycosylation in active adenosine deaminase 2 production.  Biochim Biophys Acta Gen Subj  2022  1866(12):130237  PubMed ID: 36029899   DOI: 10.1016/j.bbagen.2022.130237
20957  Yokohata S, Ohkura K, Nagamune H, Tomoyasu T, Tabata A.  Human serum albumin stabilizes streptolysin S activity secreted in the extracellular milieu by streptolysin S-producing streptococci.  Microbiol Immunol  2022    PubMed ID: 36478453   DOI: 10.1111/1348-0421.13042
13032  Kanai R, Nakashima A, Doi S, Kimura T, Yoshida K, Maeda S, Ishiuchi N, Yamada Y, Ike T, Doi T, Kato Y, Masaki T.  Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis.  Sci Rep  2021    PubMed ID: 33441701   DOI: 10.1038/s41598-020-79664-6
13296  Nakatani K, Matsuo H, Harata Y, Higashitani M, Koyama A, Noura M, Nishinaka-Arai Y, Kamikubo Y, Adachi S.  Inhibition of CDK4/6 and autophagy synergistically induces apoptosis in t(8;21) acute myeloid leukemia cells.  Int J Hematol  2021  113(2):243-253  PubMed ID: 33068248   DOI: 10.1007/s12185-020-03015-4
13347  Fujita M, Yamamoto H, Yoshida N, Ono R, Matsuoka T, Kihara S.  Atheroprotective Roles of Adiponectin via CCL2 Inhibition.  J Atheroscler Thromb  2021  28(11):1204-1213  PubMed ID: 33191365   DOI: 10.5551/jat.58875
13382  Li H, Somiya M, Kuroda S.  Enhancing antibody-dependent cellular phagocytosis by Re-education of tumor-associated macrophages with resiquimod-encapsulated liposomes.  Biomaterials  2021    PubMed ID: 33338932   DOI: 10.1016/j.biomaterials.2020.120601
13541  Itoh K, Shigemi H, Chihara K, Sada K, Yamauchi T, Iwasaki H.  Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: possible involvement of the spleen tyrosine kinase pathway  Transl Res  2021  227:53-63  PubMed ID: 32687976   DOI: 10.1016/j.trsl.2020.07.005
20199  Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S.  Extracellular mRNA transported to the nucleus exerts translation-independent function.  Nat Commun  2021  12(1):3655  PubMed ID: 34135341   DOI: 10.1038/s41467-021-23969-1
20239  Kawakatsu K, Maemura M, Seta Y, Nishikata T.  Involvement of Annexin A2 in Serum-MAF Dependent Phagocytic Activation of Macrophages.  Anticancer Res  2021  41(8):4089-4092  PubMed ID: 34281879   DOI: 10.21873/anticanres.15211
15109  Minoru Sasaki, Yu Shimoyama, Yoshitoyo Kodama, Taichi Ishikawa  Abiotrophia defectiva DnaK Promotes Fibronectin-Mediated Adherence to HUVECs and Induces a Proinflammatory Response  International Journal of Molecular Sciences  2021  22(8528)  PubMed ID: 34445234   DOI: 10.3390/ijms22168528
15492  Lee S, Ishitsuka A, Kuroki T, Lin YH, Shibuya A, Hongu T, Funakoshi Y, Kanaho Y, Nagata K, Kawaguchi A.  Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes  JCI Insight  2021  6(16):e139190  PubMed ID: 34423792   DOI: 10.1172/jci.insight.139190
20374  Kato S, Arasaki K, Tokutomi N, Imai Y, Inoshita T, Hattori N, Sasaki T, Sato M, Wakana Y, Inoue H, Tagaya M.  Syntaxin 17, an ancient SNARE paralog, plays different and conserved roles in different organisms.  J Cell Sci  2021    PubMed ID: 34704591   DOI: 10.1242/jcs.258699
20487  Sakamaki I, Fukushi M, Ohashi W, Tanaka Y, Itoh K, Tomihara K, Yamamoto Y, Iwasaki H.  Sitafloxacin reduces tumor necrosis factor alpha (TNFα) converting enzyme (TACE) phosphorylation and activity to inhibit TNFα release from lipopolysaccharide-stimulated THP-1 cells.  Sci Rep  2021  11(1):24154  PubMed ID: 34921186   DOI: 10.1038/s41598-021-03511-5
20490  Ito F, Kato K, Yanatori I, Murohara T, Toyokuni S.  Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.  Redox Biol  2021  47:102174  PubMed ID: 34700146   DOI: 10.1016/j.redox.2021.102174
20561  Sasaki M, Shimoyama Y, Kodama Y, Ishikawa T.  Tryptophanyl tRNA Synthetase from Human Macrophages Infected by Porphyromonas gingivalis Induces a Proinflammatory Response Associated with Atherosclerosis.  Pathogens  2021  10(12)  PubMed ID: 34959604   DOI: 10.3390/pathogens10121648
10948  Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura  Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages  Front Immunol  2020  11:709  PubMed ID: 32373130   DOI: 10.3389/fimmu.2020.00709
10952  Seiichi Sato, Kai Li, Nozomi Sakurai, Mei Hashizume, Sunanda Baidya, Hirotaka Nonaka, Koki Noguchi, Kozo Ishikawa, Chikashi Obuse, Akinori Takaoka  Regulation of an adaptor protein STING by Hsp90β to enhance innate immune responses against microbial infections  Cell Immunol  2020  356:104188  PubMed ID: 32763501   DOI: 10.1016/j.cellimm.2020.104188
12599  Kobayashi N, Oda T, Takizawa M, Ishizaki T, Tsukamoto N, Yokohama A, Takei H, Saitoh T, Shimizu H, Honma K, Kimura-Masuda K, Kuroda Y, Ishihara R, Murakami Y, Murakami H, Handa H.  Integrin α7 and Extracellular Matrix Laminin 211 Interaction Promotes Proliferation of Acute Myeloid Leukemia Cells and Is Associated with Granulocytic Sarcoma  Cancers (Basel)  2020  12(2):363  PubMed ID: 32033262   DOI: 10.3390/cancers12020363
13083  Matsushita M, Nakamura T, Moriizumi H, Miki H, Takekawa M.  Stress-responsive MTK1 SAPKKK serves as a redox sensor that mediates delayed and sustained activation of SAPKs by oxidative stress.  Sci Adv  2020    PubMed ID: 32637591   DOI: 10.1126/sciadv.aay9778
13133  Tabata A, Ohkuni H, Hino H, Saigo T, Kodama C, Tang Q, Tomoyasu T, Fukunaga Y, Itoh Y, Nagamune H.  Cytotoxic property of Streptococcus mitis strain producing two different types of cholesterol-dependent cytolysins.  Infect Genet Evol  2020    PubMed ID: 32731044   DOI: 10.1016/j.meegid.2020.104483
13143  Akamatsu M, Mashiba R, Kawakatsu K, Ishikawa M, Nishikata T.  Comparison of Macrophage Activation Using γ-Globulin and Serum-derived Macrophage Activating Factor.  Anticancer Res  2020    PubMed ID: 32727796   DOI: 10.21873/anticanres.14471
13307  Yanaizu M, Washizu C, Nukina N, Satoh JI, Kino Y.  CELF2 regulates the species-specific alternative splicing of TREM2.  Sci Rep  2020    PubMed ID: 33093587   DOI: 10.1038/s41598-020-75057-x
13354  Noura M, Morita K, Kiyose H, Matsuo H, Nishinaka-Arai Y, Kurokawa M, Kamikubo Y, Adachi S.  Pivotal role of DPYSL2A in KLF4-mediated monocytic differentiation of acute myeloid leukemia cells.  Sci Rep  2020    PubMed ID: 33219287   DOI: 10.1038/s41598-020-76951-0
13456  Hideo Kataoka, Ayumi Saeki, Akira Hasebe, Ken-ichiro Shibata, Takeshi Into  Naringenin suppresses Toll-like receptor 2-mediated inflammatory responses through inhibition of receptor clustering on lipid rafts  Food Sci Nutr  2020    PubMed ID: 33598179   DOI: 10.1002/fsn3.2063
4052  Kidoya H, Muramatsu F, Shimamura T, Jia W, Satoh T, Hayashi Y, Naito H, Kunisaki Y, Arai F, Seki M, Suzuki Y, Osawa T, Akira S, Takakura N.  Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis  Nat Commun  2019  10:1072  PubMed ID: 30842549   DOI: 10.1038/s41467-019-09028-w
11472  Suzuki S, Fukuda T, Nagayasu S, Nakanishi J, Yoshida K, Hirata-Tsuchiya S, Nakao Y, Sano T, Yamashita A, Yamada S, Ohta K, Shiba H, Nishimura F.  Dental pulp cell-derived powerful inducer of TNF-α comprises PKR containing stress granule rich microvesicles.  Sci Rep  2019    PubMed ID: 30846715   DOI: 10.1038/s41598-019-40046-2
6911  Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H.  β-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.  J Oral Microbiol  2019  11(1):1609839.   PubMed ID: 31105901   DOI: 10.1080/20002297.2019.1609839
6929  Minato KI, Laan LC, van Die I, Mizuno M.  Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation.  Int J Biol Macromol  2019  122:705-712  PubMed ID: 30392853   DOI: 10.1016/j.ijbiomac.2018.10.157
6943  Yamamoto M, Matsumura R, Hirata Y, Nagamune H.  A comparative study of skin irritation caused by novel bis-quaternary ammonium compounds and commonly used antiseptics by using cell culture methods.  Toxicol In Vitro  2019  54:75-81  PubMed ID: 30240708   DOI: 10.1016/j.tiv.2018.09.009
10946  Tsubasa Koga, Keiko Morotomi-Yano, Takashi Sakugawa, Hisato Saitoh, Ken-Ichi Yano  Nanosecond pulsed electric fields induce extracellular release of chromosomal DNA and histone citrullination in neutrophil-differentiated HL-60 cells  Sci Rep  2019  9(1):8451  PubMed ID: 31186478   DOI: 10.1038/s41598-019-44817-9
12329  Iwashima T, Kudome Y, Kishimoto Y, Saita E, Tanaka M, Taguchi C, Hirakawa S, Mitani N, Kondo K, Iida K.  Aronia berry extract inhibits TNF-α-induced vascular endothelial inflammation through the regulation of STAT3  Food Nutr Res  2019  16;63  PubMed ID: 31452653   DOI: 10.29219/fnr.v63.3361
12559  Li F, Kitajima S, Kohno S, Yoshida A, Tange S, Sasaki S, Okada N, Nishimoto Y, Muranaka H, Nagatani N, Suzuki M, Masuda S, Thai TC, Nishiuchi T, Tanaka T, Barbie DA, Mukaida N, Takahashi C.  Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion  Cancer Res  2019  79(15):3903-3915  PubMed ID: 31189648   DOI: 10.1158/0008-5472.CAN-18-3604
12597  Horiguchi Y, Ohta N, Yamamoto S, Koide M, Fujino Y.  Midazolam suppresses the lipopolysaccharide-stimulated immune responses of human macrophages via translocator protein signaling  Int Immunopharmacol  2019  66:373-382.  PubMed ID: 30530051   DOI: 10.1016/j.intimp.2018.11.050
12600  Giriwono PE, Shirakawa H, Ohsaki Y, Sato S, Aoyama Y, Ho HJ, Goto T, Komai M.  Geranylgeraniol Suppresses the Expression of IRAK1 and TRAF6 to Inhibit NFκB Activation in Lipopolysaccharide-Induced Inflammatory Responses in Human Macrophage-Like Cells  Int J Mol Sci  2019  20(9):2320  PubMed ID: 31083375   DOI: 10.3390/ijms20092320
10592  Yamazoe H.  Multifunctional protein microparticles for medical applications.  Biomaterials  2018  155:1-12  PubMed ID: 29154040   DOI: 10.1016/j.biomaterials.2017.10.045
11096  Sumide K, Matsuoka Y, Kawamura H, Nakatsuka R, Fujioka T, Asano H, Takihara Y, Sonoda Y.  A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.  Nat Commun  2018  9(1):2202  PubMed ID: 29875383   DOI: 10.1038/s41467-018-04441-z
11176  Watanabe K, Suzuki H, Nishida T, Mishima M, Tachibana M, Fujishima M, Shimizu T, Watarai M.  Identification of novel Legionella genes required for endosymbiosis in Paramecium based on comparative genome analysis with Holospora spp.  FEMS Microbiol. Ecol.  2018  94(11)  PubMed ID: 30124811   DOI: 10.1093/femsec/fiy162
11247  Zhitnyuk Y, Gee P, Lung MSY, Sasakawa N, Xu H, Saito H, Hotta A.  Efficient mRNA delivery system utilizing chimeric VSVG-L7Ae virus-like particles.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30316514   DOI: 10.1016/j.bbrc.2018.09.113
11288  Segawa S, Kondo Y, Nakai Y, Iizuka A, Kaneko S, Yokosawa M, Furuyama K, Tsuboi H, Goto D, Matsumoto I, Sumida T.  Placenta Specific 8 Suppresses IL-18 Production through Regulation of Autophagy and Is Associated with Adult Still Disease.  J. Immunol.  2018    PubMed ID: 30404814   DOI: 10.4049/jimmunol.1800667
4362  Nagai K, Domon H, Maekawa T, Oda M, Hiyoshi T, Tamura H, Yonezawa D, Arai Y, Yokoji M, Tabeta K, Habuka R, Saitoh A, Yamaguchi M, Kawabata S, Terao Y.  Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.  Cell. Immunol.  2018  325:14-22  PubMed ID: 29366563   DOI: 10.1016/j.cellimm.2018.01.006
4363  Yoshino H, Konno H, Ogura K, Sato Y, Kashiwakura I.  Relationship between the Regulation of Caspase-8-Mediated Apoptosis and Radioresistance in Human THP-1-Derived Macrophages.  Int J Mol Sci  2018    PubMed ID: 30322167   DOI: 10.3390/ijms19103154
4364  Mashiba R, Ishikawa M, Sumiya YU, Kawakatsu K, Tran NK, Nishikata T.  Phagocytic Activation of Macrophages with Serum MAF Depends on Engulfment Efficiency and Not Migratory Activity.  Anticancer Res.  2018  38(7):4295-4298  PubMed ID: 29970564   DOI: 10.21873/anticanres.12727
4365  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.  NF‑κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle‑induced interleukin‑1β production: Inhibition of the PM2.5‑induced inflammation model.  Mol Med Rep  2018  18(6):5279-5285  PubMed ID: 30320338   DOI: 10.3892/mmr.2018.9533
4366  Komoda H, Shiraki A, Oyama JI, Nishikido T, Node K.  Azelnidipine Inhibits the Differentiation and Activation of THP-1 Macrophages through the L-Type Calcium Channel.  J. Atheroscler. Thromb.  2018  25(8):690-69  PubMed ID: 29398679   DOI: 10.5551/jat.41798
4506  Ebe H, Matsumoto I, Kawaguchi H, Kurata I, Tanaka Y, Inoue A, Kondo Y, Tsuboi H, Sumida T.  Clinical and functional significance of STEAP4-splice variant in CD14+ monocytes in patients with rheumatoid arthritis.  Clin. Exp. Immunol.  2018  191(3):338-348  PubMed ID: 29080328   DOI: 10.1111/cei.13076
4507  Yoshida K, Nakashima A, Doi S, Ueno T, Okubo T, Kawano KI, Kanawa M, Kato Y, Higashi Y, Masaki T.  Serum-Free Medium Enhances the Immunosuppressive and Antifibrotic Abilities of Mesenchymal Stem Cells Utilized in Experimental Renal Fibrosis.  Stem Cells Transl Med  2018  7(12):893-905  PubMed ID: 30269426   DOI: 10.1002/sctm.17-0284
10181  Yoshino H, Kumai Y, Kashiwakura I.  Effects of endoplasmic reticulum stress on apoptosis induction in radioresistant macrophages.  Mol Med Rep  2017  15:2867-2872  PubMed ID: 28447729   DOI: 10.3892/mmr.2017.6298
4520  Ken-ichiro Minato, Akihiro Ohara, and Masashi Mizuno  A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action  Mediators of Inflammation  2017  9  PubMed ID: 28611507   DOI: 10.1155/2017/8402405
4546  Arasaki K, Mikami Y, Shames SR, Inoue H, Wakana Y, Tagaya M.  Legionella effector Lpg1137 shuts down ER-mitochondria communication through cleavage of syntaxin 17.  Nat Commun  2017  8:15406  PubMed ID: 28504273   DOI: 10.1038/ncomms15406
10964  Masataka Oda, Hisanori Domon, Mie Kurosawa, Toshihito Isono, Tomoki Maekawa, Masaya Yamaguchi, Shigetada Kawabata, Yutaka Terao   Streptococcus pyogenes Phospholipase A 2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice  Front Cell Infect Microbiol  2017  7:300  PubMed ID: 28713783   DOI: 10.3389/fcimb.2017.00300
14596  Yoshino H, Kashiwakura I.  Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells  J Radiat Res  2017  58(5):626-635  PubMed ID: 28369600   DOI: 10.1093/jrr/rrx011
14666  Tabei Y, Sugino S, Eguchi K, Tajika M, Abe H, Nakajima Y, Horie M.  Effect of calcium carbonate particle shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages  Biochem Biophys Res Commun  2017  490(2):499-505  PubMed ID: 28624457   DOI: 10.1016/j.bbrc.2017.06.069
14711  Hojo K, Tamai R, Kobayashi-Sakamoto M, Kiyoura Y.  Etidronate down-regulates Toll-like receptor (TLR) 2 ligand-induced proinflammatory cytokine production by inhibiting NF-κB activation  Pharmacol Rep  2017  69(4):773-778  PubMed ID: 28587938   DOI: 10.1016/j.pharep.2017.03.009
7107  Yamazoe H, Ichikawa T, Hagihara Y, Iwasaki Y.  Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.  Acta Biomater  2016  31:231-240  PubMed ID: 26685756   DOI: 10.1016/j.actbio.2015.12.016
9865  Seike S, Takehara M, Kobayashi K, Nagahama M.  Role of pannexin 1 in Clostridium perfringens beta-toxin-caused cell death.  Biochim. Biophys. Acta  2016  1858:3150-3156  PubMed ID: 27720686   DOI: 10.1016/j.bbamem.2016.10.003
9972  Uchida H, Hasegawa Y, Takahashi H, Makishima M.  1α-Dihydroxyvitamin D3 and Retinoic Acid Increase Nuclear Vitamin D Receptor Expression in Monocytic THP-1 Cells.  Anticancer Res.  2016  36:6297-6301  PubMed ID: 27919949   DOI: 10.21873/anticanres.11225
12919  Deo VK, Kato T, Park EY.  Virus-Like Particles Displaying Recombinant Short-Chain Fragment Region and Interleukin 2 for Targeting Colon Cancer Tumors and Attracting Macrophages  J Pharm Sci  2016  105(5):1614-1622  PubMed ID: 27037014   DOI: 10.1016/j.xphs.2016.02.011
12957  Kameoka S, Kameyama T, Hayashi T, Sato S, Ohnishi N, Hayashi T, Murata-Kamiya N, Higashi H, Hatakeyama M, Takaoka A.  Helicobacter pylori induces IL-1β protein through the inflammasome activation in differentiated macrophagic cells  Biomed Res  2016  37(1):21-7.  PubMed ID: 26912137   DOI: 10.2220/biomedres.37.21
13972  Tanaka M, Kishimoto Y, Saita E, Suzuki-Sugihara N, Kamiya T, Taguchi C, Iida K, Kondo K.  Terminalia bellirica Extract Inhibits Low-Density Lipoprotein Oxidation and Macrophage Inflammatory Response in Vitro  Antioxidants (Basel)  2016  5(2):20  PubMed ID: 27314393   DOI: 10.3390/antiox5020020
14035  Sumiya YU, Inoue T, Ishikawa M, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T.  Macrophages Exhibit a Large Repertoire of Activation States via Multiple Mechanisms of Macrophage-activating Factors  Anticancer Res  2016  36(7):3619-23.  PubMed ID: 27354632  
7231  Yoshida K, Maekawa T, Zhu Y, Renard-Guillet C, Chatton B, Inoue K, Uchiyama T, Ishibashi K, Yamada T, Ohno N, Shirahige K, Okada-Hatakeyama M, Ishii S.  The transcription factor ATF7 mediates lipopolysaccharide-induced epigenetic changes in macrophages involved in innate immunological memory.  Nat. Immunol.  2015  16:1034-43  PubMed ID: 26322480   DOI: 10.1038/ni.3257
7239  Nagahama M, Seike S, Shirai H, Takagishi T, Kobayashi K, Takehara M, Sakurai J.  Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury.  Biochim. Biophys. Acta  2015  1850:2159-67  PubMed ID: 26299247   DOI: 10.1016/j.bbagen.2015.08.011
7251  Yanagisawa K, Ogawa Y, Uchiumi H, Gohda F, Mawatari M, Ishizaki T, Mitsui T, Yokohama A, Handa H, Tsukamoto N, Nojima Y.  Gene polymorphisms of mannose-binding lectin confer susceptibility to Pneumocystis pneumonia in HIV-infected patients.  J. Infect. Chemother.  2015  21:769-75  PubMed ID: 26271591   DOI: 10.1016/j.jiac.2015.07.006
7288  Inoue T, Ishikawa M, Sumiya Y, Kohda H, Inui T, Kuchiike D, Kubo K, Uto Y, Nishikata T.  Establishment of a Macrophage-activating Factor Assay System Using the Human Monocytic Cell Line THP-1.  Anticancer Res.  2015  35:4441-5  PubMed ID: 26168484  
7316  Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, Morita R.  Bruton's tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury.  Nat Commun  2015  6:7360  PubMed ID: 26059659   DOI: 10.1038/ncomms8360
7533  Jian Sun, Hiroko Shigemi, Yukie Tanaka, Takahiro Yamauchi, Takanori Ueda, Hiromichi Iwasaki  Tetracyclines downregulate the production of LPS-induced cytokines and chemokines in THP-1 cells via ERK, p38, and nuclear factor-κB signaling pathways.  Biochemistry and Biophysics Reports  2015  4:397-404  PubMed ID: 29124230   DOI: 10.1016/j.bbrep.2015.11.003
7556  S Yoshimatsu, T Kato-Matsumaru, A Aono, K Chikamatsu, H Yamada, S Mitarai  Factors contribute to efficiency of specimen concentration of Mycobacterium tuberculosis by centrifugation and magnetic beads.  International Journal of Mycobacteriology  2015  4:245-249  PubMed ID: 27649873   DOI: 10.1016/j.ijmyco.2015.05.014
10969  Takuya Shimizu, Yusuke Masuo, Saki Takahashi, Noritaka Nakamichi, Yukio Kato  Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice  Drug Metab Pharmacokinet  2015  30(3):231-9  PubMed ID: 26003890   DOI: 10.1016/j.dmpk.2015.02.003
15006  Nakayama S, Kishimoto Y, Saita E, Sugihara N, Toyozaki M, Taguchi C, Tani M, Kamiya T, Kondo K.  Pine bark extract prevents low-density lipoprotein oxidation and regulates monocytic expression of antioxidant enzymes  Nutr Res  2015  35(1):56-64  PubMed ID: 25458248   DOI: 10.1016/j.nutres.2014.10.010
15028  Inaba H, Yoshigai E, Okuyama T, Murakoshi M, Sugiyama K, Nishino H, Nishizawa M.  Antipyretic analgesic drugs have different mechanisms for regulation of the expression of inducible nitric oxide synthase in hepatocytes and macrophages  Nitric Oxide  2015  44:61-70  PubMed ID: 25499030   DOI: 10.1016/j.niox.2014.12.001
15175  Matsubara K, Matsushita Y, Sakai K, Kano F, Kondo M, Noda M, Hashimoto N, Imagama S, Ishiguro N, Suzumura A, Ueda M, Furukawa K, Yamamoto A.  Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity  J Neurosci  2015  35(6):2452-64  PubMed ID: 25673840   DOI: 10.1523/JNEUROSCI.4088-14.2015
15442  Masanori Horie, Keiko Nishio, Haruhisa Kato, Shigehisa Endoh, Katsuhide Fujita, Ayako Nakamura, Arisa Miyauchi, Shinichi Kinugasa, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi  The Expression of Inflammatory Cytokine and Heme Oxygenase-1 Genes in THP-1 Cells Exposed to Metal Oxide Nanoparticles  Journal of Nano Research  2015  30:116-127    DOI: 10.4028/www.scientific.net/jnanor.30.116
15454  Masanori Horie, Haruhisa Kato, Shigehisa Endoh, Ayako Nakamura, Junko Maru, Naohide Shinohara, Katsuhide Fujita  Effects of Various Carbon Nanotube Suspensions on A549, THP-1, and Peritoneal Macrophage Cells  Journal of Biomimetics, Biomaterials and Biomedical Engineering  2015  24:1-13    DOI: 10.4028/www.scientific.net/jbbbe.24.1
15479  Ito S, Tanaka Y, Oshino R, Aiba K, Thanasegaran S, Nishio N, Isobe K.  GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy  Sci Rep  2015  5:8327  PubMed ID: 25659802   DOI: 10.1038/srep08327
12955  Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mouriño, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada  Synthesis, Biological Activities, and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds  Journal of Medicinal Chemistry  2015  58:9510-9521  PubMed ID: 26613420   DOI: 10.1021/acs.jmedchem.5b00792
3320  Yoshino H, Saitoh T, Kozakai M, Kashiwakura I.  Effects of ionizing radiation on retinoic acid-inducible gene-I-like receptors  Biomed Rep  2015  3(1):59-62  PubMed ID: 25469248   DOI: 10.3892/br.2014.377
18177  Okada M, Matsuzawa A, Yoshimura A, Ichijo H.  The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation  J Biol Chem  2014  289(47):32926-36  PubMed ID: 25288801   DOI: 10.1074/jbc.M114.579961
5633  Tung NH, Suzuki M, Uto T, Morinaga O, Kwofie KD, Ammah N, Koram KA, Aboagye F, Edoh D, Yamashita T, Yamaguchi Y, Setsu T, Yamaoka S, Ohta N, Shoyama Y.  Anti-trypanosomal activity of diarylheptanoids isolated from the bark of Alnus japonica.  Am J Chin Med  2014  42(5):1245-60  PubMed ID: 25178281   DOI: 10.1142/S0192415X14500785
6468  Takahashi H, Hatta Y, Iriyama N, Hasegawa Y, Uchida H, Nakagawa M, Makishima M, Takeuchi J, Takei M.  Induced differentiation of human myeloid leukemia cells into M2 macrophages by combined treatment with retinoic acid and 1α,25-dihydroxyvitamin D3.  PLoS One  2014  9(11):e113722  PubMed ID: 25409436   DOI: 10.1371/journal.pone.0113722
15308  Hayashi Y, Kuroda T, Kishimoto H, Wang C, Iwama A, Kimura K.  Downregulation of rRNA transcription triggers cell differentiation  PLoS One  2014  9(5):e98586  PubMed ID: 24879416   DOI: 10.1371/journal.pone.0098586
16008  Kawakami Y, Hirano S, Kinoshita M, Otsuki A, Suzuki-Yamamoto T, Suzuki M, Kimoto M, Sasabe S, Fukushima M, Kishimoto K, Izumi T, Oga T, Narumiya S, Sugahara M, Miyano M, Yamamoto S, Takahashi Y.  Neutralization of leukotriene C4 and D4 activity by monoclonal and single-chain antibodies  Biochim Biophys Acta  2014  1840(6):1625-33  PubMed ID: 24361619   DOI: 10.1016/j.bbagen.2013.12.016
17167  Fukushi Y , Yoshino H , Ishikawa J , Sagisaka M , Kashiwakura I , Yoshizawa A .  Synthesis and anticancer properties of phenyl benzoate derivatives possessing a terminal hydroxyl group  J Mater Chem B  2014  2(10):1335-1343  PubMed ID: 32261448   DOI: 10.1039/c3tb21736a
18663  Miyamoto-Sasaki M, Yasuda T, Monguchi T, Nakajima H, Mori K, Toh R, Ishida T, Hirata K.  Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients  J Atheroscler Thromb  2013  20(9):708-16  PubMed ID: 23739642   DOI: 10.5551/jat.17210
9097  Masahiro Nagahama, Masahiro Shibutani, Soshi Seike, Mami Yonezaki, Teruhisa Takagishi, Masataka Oda, Keiko Kobayashi, Jun Sakurai  The p38 MAPK and JNK Pathways Protect Host Cells Against Clostridium Perfringens Beta-Toxin  Infect Immun  2013  81 (10), 3703-8  PubMed ID: 23876806   DOI: 10.1128/IAI.00579-13
15772  Masanori Saito, Osamu Tsuzukibashi, Noriko Shinozaki-Kuwahara, Taira Kobayashi, Kazuko Takada  Anticytotoxic Effect of Green Tea Catechin on Lipopolysaccharide from Aggregatibacter actinomycetemcomitans  International Journal of Oral-Medical Sciences  2013  11:202-206    DOI: 10.5466/ijoms.11.202
15795  Wang X, Li X, Onuma K, Sogo Y, Ohno T, Ito A.  Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy  Sci Rep  2013  3:2203  PubMed ID: 23857555   DOI: 10.1038/srep02203
15933  Koyama T, Sun B, Tokunaga K, Tatsumi M, Ishizaka Y.  DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition  Retrovirology  2013  10:21  PubMed ID: 23432899   DOI: 10.1186/1742-4690-10-21
17159  Oya K, Sakamoto N, Sato M.  Hypoxia suppresses stretch-induced elongation and orientation of macrophages   Biomed Mater Eng  2013  23(6):463-71  PubMed ID: 24165549   DOI: 10.3233/BME-130770
7638  Satoh J, Shimamura Y, Tabunoki H.  Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease.  Cell. Mol. Neurobiol.  2012  32:337-43  PubMed ID: 22080356   DOI: 10.1007/s10571-011-9769-z
6091  Shimada E, Kataoka H, Miyazawa Y, Yamamoto M, Igarashi T.  Lipoproteins of Actinomyces viscosus induce inflammatory responses through TLR2 in human gingival epithelial cells and macrophages.  Microbes Infect  2012  14(11):916-21  PubMed ID: 22561467   DOI: 10.1016/j.micinf.2012.04.015
10968  Hiroharu Kobayashi, Yoriko Yamashita, Akira Iwase, Yutaka Yoshikawa, Hiroyuki Yasui, Yoshichika Kawai, Koji Uchida, Nozomi Uno, Shinya Akatsuka, Takashi Takahashi, Fumitaka Kikkawa, Shinya Toyokuni  The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis  Fertil Steril  2012  98(2):415-22.e1-12  PubMed ID: 22633261   DOI: 10.1016/j.fertnstert.2012.04.047
12723  Daniele E, Govoni S, Lograno MD.  The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation  Biochim Biophys Acta  2012  1820(11):1753-63  PubMed ID: 22842481   DOI: 10.1016/j.bbagen.2012.07.007
15343  Iizuka M, Ayaori M, Uto-Kondo H, Yakushiji E, Takiguchi S, Nakaya K, Hisada T, Sasaki M, Komatsu T, Yogo M, Kishimoto Y, Kondo K, Ikewaki K.  Astaxanthin enhances ATP-binding cassette transporter A1/G1 expressions and cholesterol efflux from macrophages  J Nutr Sci Vitaminol (Tokyo)  2012  58(2):96-104  PubMed ID: 22790567   DOI: 10.3177/jnsv.58.96
7695  Kanai Y, Hiroki S, Koshino H, Konoki K, Cho Y, Cayme M, Fukuyo Y, Yotsu-Yamashita M.  Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissue.  J. Lipid Res.  2011  52:2245-54  PubMed ID: 21893678   DOI: 10.1194/jlr.M017053
7701  Oya K, Sakamoto N, Ohashi T, Sato M.  Combined stimulation with cyclic stretching and hypoxia increases production of matrix metalloproteinase-9 and cytokines by macrophages.  Biochem. Biophys. Res. Commun.  2011  412:678-82  PubMed ID: 21867689   DOI: 10.1016/j.bbrc.2011.08.024
7813  Taira M, Shimoyama Y, Kagiya T, Sasaki M, Nezu T, Harada H, Kimura S.  Proteome analyses of human macrophages exposed to low cytotoxic IC90 copper (2+) ions.  Dent Mater J  2011  30:293-9  PubMed ID: 21597227   DOI: 10.4012/dmj.2010-088
7886  Saito Y, Nakahata S, Yamakawa N, Kaneda K, Ichihara E, Suekane A, Morishita K.  CD52 as a molecular target for immunotherapy to treat acute myeloid leukemia with high EVI1 expression.  Leukemia  2011  25:921-31  PubMed ID: 21394097   DOI: 10.1038/leu.2011.36
8120  Mizuno K, Toyoda Y, Fukami T, Nakajima M, Yokoi T.  Stimulation of pro-inflammatory responses by mebendazole in human monocytic THP-1 cells through an ERK signaling pathway.  Arch. Toxicol.  2011  85:199-207  PubMed ID: 20848085   DOI: 10.1007/s00204-010-0584-y
5413  Haniu H, Saito N, Matsuda Y, Kim YA, Park KC, Tsukahara T, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H.  Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines.  Int J Nanomedicine  2011  6:3487-97  PubMed ID: 22267932   DOI: 10.2147/IJN.S26689
9085  Takeshi Shimizu, Yuko Ohta, Hiroyasu Tsutsuki, Masatoshi Noda  Construction of a Novel Bioluminescent Reporter System for Investigating Shiga Toxin Expression of Enterohemorrhagic Escherichia Coli  Gene  2011  478 (1-2), 1-10  PubMed ID: 21262333   DOI: 10.1016/j.gene.2011.01.006
13999  Okahashi N, Okinaga T, Sakurai A, Terao Y, Nakata M, Nakashima K, Shintani S, Kawabata S, Ooshima T, Nishihara T.  Streptococcus sanguinis induces foam cell formation and cell death of macrophages in association with production of reactive oxygen species  FEMS Microbiol Lett  2011  323(2):164-70  PubMed ID: 22092716   DOI: 10.1111/j.1574-6968.2011.02375.x
16309  Haniu H, Tsukahara T, Matsuda Y, Usui Y, Aoki K, Shimizu M, Ogihara N, Hara K, Takanashi S, Okamoto M, Ishigaki N, Nakamura K, Kato H, Saito N.  DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes  Int J Nanomedicine  2011  6:2689-95  PubMed ID: 22114499   DOI: 10.2147/IJN.S25471
8130  Mizuno K, Fukami T, Toyoda Y, Nakajima M, Yokoi T.  Terbinafine stimulates the pro-inflammatory responses in human monocytic THP-1 cells through an ERK signaling pathway.  Life Sci.  2010  87:537-44  PubMed ID: 20816994   DOI: 10.1016/j.lfs.2010.08.010
8148  Nakaya K, Ayaori M, Uto-Kondo H, Hisada T, Ogura M, Yakushiji E, Takiguchi S, Terao Y, Ozasa H, Sasaki M, Komatsu T, Ohsuzu F, Ikewaki K.  Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo.  Atherosclerosis  2010  213:135-41  PubMed ID: 20723893   DOI: 10.1016/j.atherosclerosis.2010.07.024
8264  Yokoi H, Mizukami H, Nagatsu A, Tanabe H, Inoue M.  Hydroxy monounsaturated fatty acids as agonists for peroxisome proliferator-activated receptors.  Biol. Pharm. Bull.  2010  33:854-61  PubMed ID: 20460766   DOI: 10.1248/bpb.33.854
8393  Uto-Kondo H, Ayaori M, Ogura M, Nakaya K, Ito M, Suzuki A, Takiguchi S, Yakushiji E, Terao Y, Ozasa H, Hisada T, Sasaki M, Ohsuzu F, Ikewaki K.  Coffee consumption enhances high-density lipoprotein-mediated cholesterol efflux in macrophages.  Circ. Res.  2010  106:779-87  PubMed ID: 20075335   DOI: 10.1161/CIRCRESAHA.109.206615
8402  Iizuka M, Tani M, Kishimoto Y, Saita E, Toyozaki M, Kondo K.  Inhibitory effects of balsamic vinegar on LDL oxidation and lipid accumulation in THP-1 macrophages.  J. Nutr. Sci. Vitaminol.  2010  56:421-7  PubMed ID: 21422711   DOI: 10.3177/jnsv.56.421
8413  Lu X, Ohata K, Kondo Y, Espinoza JL, Qi Z, Nakao S.  Hydroxyurea upregulates NKG2D ligand expression in myeloid leukemia cells synergistically with valproic acid and potentially enhances susceptibility of leukemic cells to natural killer cell-mediated cytolysis.  Cancer Sci.  2010  101:609-15  PubMed ID: 20028385   DOI: 10.1111/j.1349-7006.2009.01439.x
8526  Taira M, Kagiya T, Harada H, Sasaki M, Kimura S, Narushima T, Nezu T, Araki Y.  Microscopic observations and inflammatory cytokine productions of human macrophage phagocytising submicron titanium particles.  J Mater Sci Mater Med  2010  21:267-75  PubMed ID: 19644653   DOI: 10.1007/s10856-009-3834-x
6125  Shimahara A, Yamakawa N, Nishikata I, Morishita K.  Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2.  J Biol Chem  2010  285(22):16967-77  PubMed ID: 20363750   DOI: 10.1074/jbc.M110.102046
9080  Akihiro Unno, Katsuya Kitoh, Yasuhiro Takashima  Up-regulation of Hyaluronan Receptors in Toxoplasma Gondii-Infected Monocytic Cells  Biochem Biophys Res Commun  2010  391 (1), 477-80  PubMed ID: 19914206   DOI: 10.1016/j.bbrc.2009.11.083
11006  Kaku Sawada, Shigeru Ariki, Takashi Kojima, Atsushi Saito, Masami Yamazoe, Chiaki Nishitani, Takeyuki Shimizu, Motoko Takahashi, Hiroaki Mitsuzawa, Shin-Ichi Yokota, Norimasa Sawada, Nobuhiro Fujii, Hiroki Takahashi, Yoshio Kuroki  Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth  J Biol Chem  2010  285(11):8434-43  PubMed ID: 20056602   DOI: 10.1074/jbc.M109.074765
8535  Watanabe T, Nishio H, Tanigawa T, Yamagami H, Okazaki H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Asahara T, Nomoto K, Higuchi K, Takeuchi K, Arakawa T.  Probiotic Lactobacillus casei strain Shirota prevents indomethacin-induced small intestinal injury: involvement of lactic acid.  Am. J. Physiol. Gastrointest. Liver Physiol.  2009  297:G506-13  PubMed ID: 19589943   DOI: 10.1152/ajpgi.90553.2008
8547  Hojo-Nakashima I, Sato R, Nakashima K, Hagiwara T, Yamada M.  Dynamic expression of peptidylarginine deiminase 2 in human monocytic leukaemia THP-1 cells during macrophage differentiation.  J. Biochem.  2009  146:471-9  PubMed ID: 19564157   DOI: 10.1093/jb/mvp097
8564  Ara T, Kurata K, Hirai K, Uchihashi T, Uematsu T, Imamura Y, Furusawa K, Kurihara S, Wang PL.  Human gingival fibroblasts are critical in sustaining inflammation in periodontal disease.  J. Periodont. Res.  2009  44:21-7  PubMed ID: 19515019   DOI: 10.1111/j.1600-0765.2007.01041.x
8579  Amano Y, Cho Y, Matsunawa M, Komiyama K, Makishima M.  Increased nuclear expression and transactivation of vitamin D receptor by the cardiotonic steroid bufalin in human myeloid leukemia cells.  J. Steroid Biochem. Mol. Biol.  2009  114:144-51  PubMed ID: 19429444   DOI: 10.1016/j.jsbmb.2009.01.022
8604  Matsuki K, Tamasawa N, Yamashita M, Tanabe J, Murakami H, Matsui J, Imaizumi T, Satoh K, Suda T.  Metformin restores impaired HDL-mediated cholesterol efflux due to glycation.  Atherosclerosis  2009  206:434-8  PubMed ID: 19376519   DOI: 10.1016/j.atherosclerosis.2009.03.003
8616  Miki Y, Itoh T, Hirano K, Eda S, Hayashi A, Yamanaka M, Beppu M.  Clearance of oxidatively damaged cells by macrophages: recognition of glycoprotein clusters by macrophage-surface nucleolin as early apoptotic cells.  Biol. Pharm. Bull.  2009  32:564-72  PubMed ID: 19336885   DOI: 10.1248/bpb.32.564
6132  Naito H, Kidoya H, Sato Y, Takakura N.  Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population.  J Biochem  2009  145(5):653-9  PubMed ID: 19179360   DOI: 10.1093/jb/mvp021
6303  Taira M, Nezu T, Sasaki M, Kimura S, Kagiya T, Harada H, Narushima T, Araki Y.  Gene expression analyses of human macrophage phagocytizing sub-micro titanium particles by allergy DNA chip (Genopal).  Biomed Mater Eng  2009  19(1):63-70  PubMed ID: 19458447   DOI: 10.3233/BME-2009-0564
16152  Ikegaya S, Inai K, Iwasaki H, Naiki H, Ueda T.  Azithromycin reduces tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells by modification of stress response and p38 MAPK pathway  J Chemother  2009  21(4):396-402  PubMed ID: 19622457   DOI: 10.1179/joc.2009.21.4.396
16561  Enomoto H, Hayashi Y, Li CP, Ohki S, Ohtomo H, Shiokawa M, Aoki T.  Glycation and phosphorylation of alpha-lactalbumin by dry heating: effect on protein structure and physiological functions  J Dairy Sci  2009  92(7):3057-68  PubMed ID: 19528583   DOI: 10.3168/jds.2009-2014
16562  Inafuku Y, Furuhata T, Tayama M, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K.  Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer  Cancer Sci  2009  100(5):852-8  PubMed ID: 19445018   DOI: 10.1111/j.1349-7006.2009.01116.x
8700  Ishii S, Katsumura T, Shiozuka C, Ooyauchi K, Kawasaki K, Takigawa S, Fukushima T, Tokuji Y, Kinoshita M, Ohnishi M, Kawahara M, Ohba K.  Anti-inflammatory effect of buckwheat sprouts in lipopolysaccharide-activated human colon cancer cells and mice.  Biosci. Biotechnol. Biochem.  2008  72:3148-57  PubMed ID: 19060399   DOI: 10.1271/bbb.80324
18734  Haraguchi G, Kosuge H, Maejima Y, Suzuki J, Imai T, Yoshida M, Isobe M.  Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis  Intensive Care Med  2008  34(7):1304-12  PubMed ID: 18283431   DOI: 10.1007/s00134-008-1024-9
5403  Hirasawa A, Itsubo C, Sadakane K, Hara T, Shinagawa S, Koga H, Nose H, Koshimizu TA, Tsujimoto G.  Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1).  Biochem Biophys Res Commun  2008  365:22-8  PubMed ID: 17980148   DOI: 10.1016/j.bbrc.2007.10.142
3586  Haga A, Funasaka T, Deyashiki Y, Raz A.  Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.  FEBS Lett.  2008  582(13):1877-82  PubMed ID: 18485900   DOI: 10.1016/j.febslet.2008.05.005
6804  Noman AS, Koide N, Khuda II, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T.  Thalidomide inhibits epidermal growth factor-induced cell growth in mouse and human monocytic leukemia cells via Ras inactivatio  Biochem Biophys Res Commun  2008  374(4):683-7  PubMed ID: 18662673   DOI: 10.1016/j.bbrc.2008.07.090
6296  Shimadoi S, Takami A, Kondo Y, Okumura H, Nakao S.  Macrophage colony-stimulating factor enhances rituximab-dependent cellular cytotoxicity by monocytes.  Cancer Sci  2007  98(9):1368-72  PubMed ID: 17640305   DOI: 10.1111/j.1349-7006.2007.00544.x
10072  Yoshinari Uehara 1, Shin-ichiro Miura, Arnold von Eckardstein, Satomi Abe, Akihiro Fujii, Yoshino Matsuo, Stephan Rust, Stefan Lorkowski, Gerd Assmann, Tatsuo Yamada, Keijiro Saku  Unsaturated fatty acids suppress the expression of the ATP-binding cassette transporter G1 (ABCG1) and ABCA1 genes via an LXR/RXR responsive element  Atherosclerosis  2007  191(1):11-21  PubMed ID: 16730733   DOI: 10.1016/j.atherosclerosis.2006.04.018
15379  Kentaro Harutsugu, Kyoko Watanabe, Michiharu Daito  The role of anti immune response on adenosine stimulated macrophages  Pediatric Dental Journal  2007  1:40-46    DOI: 10.11411/pdj.17.40
8818  Matsumoto E, Hatanaka M, Bohgaki M, Maeda S.  PKC pathway and ERK/MAPK pathway are required for induction of cyclin D1 and p21Waf1 during 12-o-tetradecanoylphorbol 13-acetate-induced differentiation of myeloleukemia cells.  Kobe J Med Sci  2006  52:181-94  PubMed ID: 17329956  
8914  Hisakage Funabashi, Riko Matsuzawaa, Makiko Nakamura, Masayasu Mie and Eiry Kobatake  Bioluminescent enumeration of surface antigen-specific cells using the streptavidin?luciferase fusion protein  Sensors and Actuators B: Chemical  2006  120:51-56    DOI: 10.1016/j.snb.2006.01.042
18569  Besson N, Hullin-Matsuda F, Makino A, Murate M, Lagarde M, Pageaux JF, Kobayashi T, Delton-Vandenbroucke I.  Selective incorporation of docosahexaenoic acid into lysobisphosphatidic acid in cultured THP-1 macrophages  Lipids  2006  41(2):189-96  PubMed ID: 17707985   DOI: 10.1007/s11745-006-5087-5
18802  Tachiwana H, Shimura M, Nakai-Murakami C, Tokunaga K, Takizawa Y, Sata T, Kurumizaka H, Ishizaka Y.  HIV-1 Vpr induces DNA double-strand breaks  Cancer Res  2006  66(2):627-31  PubMed ID: 16423988   DOI: 10.1158/0008-5472.CAN-05-3144
3538  Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H.  Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.  Toxicol In Vitro  2006  20(5):767-73  PubMed ID: 16311011   DOI: 10.1016/j.tiv.2005.10.012
3539  Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K, Hirota M, Itagaki H, Toyoda H, Suzuki H.  Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.  Toxicol In Vitro  2006  20(5):774-84  PubMed ID: 16337770   DOI: 10.1016/j.tiv.2005.10.014
3393  Isse, Kumiko, Harada, Kenichi, Zen, Yoh, Kamihira, Takashi, Shimoda, Shinji, Harada, Mine, Nakanuma, Yasuni  Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts.  Hepatology  2005  41:506-16  PubMed ID: 15726664   DOI: 10.1002/hep.20582
3270  Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, Kohgo Y.  Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.  Hepatol. Res.  2005  33:198-205  PubMed ID: 16198622   DOI: 10.1016/j.hepres.2005.08.005
18800  Mizoguchi I, Ooe Y, Hoshino S, Shimura M, Kasahara T, Kano S, Ohta T, Takaku F, Nakayama Y, Ishizaka Y.  Improved gene expression in resting macrophages using an oligopeptide derived from Vpr of human immunodeficiency virus type-1  Biochem Biophys Res Commun  2005  338(3):1499-506  PubMed ID: 16274667   DOI: 10.1016/j.bbrc.2005.10.112
2862  Liu Y, Yang H, Otaka K, Takatsuki H, Sakanishi A.  Effects of vascular endothelial growth factor (VEGF) and chondroitin sulfate A on human monocytic THP-1 cell migration.  Colloids Surf B Biointerfaces  2005  43(3-4):216-20  PubMed ID: 15978788   DOI: 10.1016/j.colsurfb.2005.04.011
2938  Harada H, Suzu S, Hayashi Y, Okada S.  BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule.  J Cell Physiol  2005  204(3):919-26  PubMed ID: 15795899   DOI: 10.1002/jcp.20361
3076  Sumita C, Yamane M, Matsuda T, Maeda M, Nariai T, Fujio Y, Azuma J.  Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages.  FEBS Lett  2005  579(18):4038-42.  PubMed ID: 16004986   DOI: 10.1016/j.febslet.2005.06.022
3349  Hirano K, Miki Y, Hirai Y, Sato R, Itoh T, Hayashi A, Yamanaka M, Eda S, Beppu M.  A multifunctional shuttling protein nucleolin is a macrophage receptor for apoptotic cells.  J Biol Chem  2005  280(47):39284-93  PubMed ID: 16135517   DOI: 10.1074/jbc.M505275200
16563  Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M.  Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells  J Immunol  2005  174(3):1566-73  PubMed ID: 15661917   DOI: 10.4049/jimmunol.174.3.1566
3075  Sumita C, Maeda M, Fujio Y, Kim J, Fujitsu J, Kasayama S, Yamamoto I, Azuma J.  Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage.  Biochim Biophys Acta  2004  1673(3):115-21  PubMed ID: 15279882   DOI: 10.1016/j.bbagen.2004.04.002
3195  Kumada M, Kihara S, Ouchi N, Kobayashi H, Okamoto Y, Ohashi K, Maeda K, Nagaretani H, Kishida K, Maeda N, Nagasawa A, Funahashi T, Matsuzawa Y.  Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.  Circulation  2004  109(17):2046-9  PubMed ID: 15096450   DOI: 10.1161/01.CIR.0000127953.98131.ED
3074  Maeda M, Yamamoto I, Fujio Y, Azuma J.  Homocysteine induces vascular endothelial growth factor expression in differentiated THP-1 macrophages.  Biochim Biophys Acta  2003  1623(1):41-6  PubMed ID: 12957716   DOI: 10.1016/s0304-4165(03)00161-2
15589  Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K.  An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis  Nat Genet   2003  35(4):341-8  PubMed ID: 14608356   DOI: 10.1038/ng1267
9032  N Kiyokawa, T Mori, T Taguchi, M Saito, K Mimori, T Suzuki, T Sekino, N Sato, H Nakajima, Y U Katagiri, T Takeda, J Fujimoto  Activation of the Caspase Cascade During Stx1-induced Apoptosis in Burkitt's Lymphoma Cells  J Cell Biochem  2001  81 (1), 128-42  PubMed ID: 11180403   DOI: 10.1002/1097-4644(20010401)81:1<128::aid-jcb1029>3.0.co;2-g
10997  K Fukuda, S Akao, Y Ohno, K Yamashita, H Fujiwara  Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1  Cancer Lett   2001  164(1):7-13  PubMed ID: 11166910   DOI: 10.1016/s0304-3835(00)00704-7
16967  Misumi S, Nakajima R, Takamune N, Shoji S.  A cyclic dodecapeptide-multiple-antigen peptide conjugate from the undecapeptidyl arch (from Arg(168) to Cys(178)) of extracellular loop 2 in CCR5 as a novel human immunodeficiency virus type 1 vaccine  J Virol   2001  11614-20  PubMed ID: 11689643   DOI: 10.1128/JVI.75.23.11614-11620.2001
11022  K Fukuda, Y Hibiya, M Mutoh, Y Ohno, K Yamashita, S Akao, H Fujiwara  Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1  Biochem Pharmacol  2000  60(4):595-600  PubMed ID: 10874135   DOI: 10.1016/s0006-2952(00)00340-3
2378  Yamasaki K, Sasaki T, Nemoto M, Eto Y, Tajima N  Differentiation-induced insulin secretion from nonendocrine cells with engineered human proinsulin cDNA.  Biochem Biophys Res Commun  1999  265:361-5  PubMed ID: 10558872   DOI: 10.1006/bbrc.1999.1698
17220  Fujii H, Nakajima M, Aoyagi T, Tsuruo T.  Inhibition of tumor cell invasion and matrix degradation by aminopeptidase inhibitors  Biol Pharm Bull  1996  19(1):6-10  PubMed ID: 8820902   DOI: 10.1248/bpb.19.6



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