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Cell No. : Cell Name
RCB1165 : YAC-1  update : 2020/01/22
CommentNatural killer cell-sensitive mouse lymphoma.Since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 96 prior to order.
Comment from the depositor
Terms and conditionsBasically, there is no restriction regarding academic use. However, since “Terms and conditions” etc. for this cell line can be changed, the users of this cell line must refer to ACC 96 prior to order.
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC( regarding any kind of for-profit use.
Basic information Depositor DSMZ
Year of deposit 1995
Animal mouse < Mammals
Tissue lymphoma
Case history leukemia
Classification cancer
History DSMZ (ACC96)
Lifespan infinite
Morphology lymphocyte-like
deposit info
lot info
Medium Medium List
Culture type Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method dilution
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : once/3-4 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
SSLP(mouse) OK
Isozyme LD, NP
deposit info
lot info
Reference information Reference 4
User's Publication 10

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4942  Tsai L, Ohlén C, Ljunggren HG, Kärre K, Hansson M, Kiessling R.  Effect of IFN-gamma treatment and in vivo passage of murine tumor cell lines on their sensitivity to lymphokine-activated killer (LAK) cell lysis in vitro; association with H-2 expression on the target cells.  Int J Cancer  1989  44(4):669-74  PubMed ID: 2507452
4941  Klein GO, Grönberg A, Kiessling R, Klein G.  Decreased sensitivity of immunoselected and NK-selected YAC lymphoma sublines to hybrid resistance in vivo.  Eur J Cancer Clin Oncol  1982  18(2):191-8  PubMed ID: 6807680
982  Kiessling R, Klein E, Wigzell H.  "Natural" killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype.  Eur J Immunol  1975  5(2):112-7  PubMed ID: 1234049
4940  Lamon EW, Gatti RA, Kiessling R, Fenyö EM.  Comparison of the allospecific and viral-specific immune responses to irradiated versus formaldehyde-fixed allogeneic Moloney lymphoma cells in CBA mice.  Cancer Res  1975  35(4):962-9  PubMed ID: 1090367

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User's Publication
6934  Baba K, Kuwada S, Nakao A, Li X, Okuda N, Nishida A, Mitsuda S, Fukuoka N, Kakeya H, Kataoka T.  Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.  Histochem Cell Biol  2020    PubMed ID: 31907597
4374  Une S, Nonaka K, Akiyama J.  Lectin Isolated from Japanese Red Sword Beans (Canavalia gladiata) as a Potential Cancer Chemopreventive Agent.  J. Food Sci.  2018  83(3):837-843  PubMed ID: 29437230
9804  Kiniwa T, Enomoto Y, Terazawa N, Omi A, Miyata N, Ishiwata K, Miyajima A.  NK cells activated by Interleukin-4 in cooperation with Interleukin-15 exhibit distinctive characteristics.  Proc. Natl. Acad. Sci. U.S.A.  2016  113:10139-44  PubMed ID: 27551096
9095  N Meshii, G Takahashi, S Okunaga, M Hamada, S Iwai, A Takasu, Y Ogawa, Y Yura  Enhancement of Systemic Tumor Immunity for Squamous Cell Carcinoma Cells by an Oncolytic Herpes Simplex Virus  Cancer Gene Ther  2013  20 (9), 493-8  PubMed ID: 23887644
3329  Iinuma, Hisae, Okinaga, Kota, Fukushima, Ryoji, Inaba, Tsuyoshi, Iwasaki, Kota, Okinaga, Akira, Takahashi, Ichiro, Kaneko, Michio  Superior protective and therapeutic effects of IL-12 and IL-18 gene-transduced dendritic neuroblastoma fusion cells on liver metastasis of murine neuroblastoma.  J Immunol  2006  176:3461-9  PubMed ID: 16517714
3331  Ebata, Kazumi, Shimizu, Yukihiro, Nakayama, Yasuhiro, Minemura, Masami, Murakami, Jun, Kato, Tsutomu, Yasumura, Satoshi, Takahara, Terumi, Sugiyama, Toshiro, Saito, Shigeru  Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model.  J Immunol  2006  176:4113-24  PubMed ID: 16547247
3169  Koga, Tomoaki, Harada, Hideki, Shi, Tea Seow, Okada, Seiji, Suico, Mary Ann, Shuto, Tsuyoshi, Kai, Hirofumi  Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression.  Biochem Biophys Res Commun  2005  337:1319-23  PubMed ID: 16236268
6153  Misawa E, Sakurai T, Yamada M, Tamura Y, Motoyoshi K.  Administration of macrophage colony-stimulating factor mobilized both CD11b+CD11c+ cells and NK1.1+ cells into peripheral blood.  Int Immunopharmacol  2004  4(6):791-803  PubMed ID: 15135320
2637  Kasahara M, Watanabe Y, Sumasu M, Nagata T  A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.  Proc Natl Acad Sci U S A  2002  99:13687-92  PubMed ID: 12370446
4711  Tanji H, Yahata H, Hayamizu K, Shinozaki K, Okimoto T, Sakaguchi T, Asahara T.  Augmentation of local antitumor immunity in liver by interleukin-2 gene transfer via portal vein.  Cancer Gene Ther  2002  9(8):655-64  PubMed ID: 12136426

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