CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB1154 : KGN]

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4933 Wu Y, Ghosh S, Nishi Y, Yanase T, Nawata H, Hu Y. The orphan nuclear receptors NURR1 and NGFI-B modulate aromatase gene expression in ovarian granulosa cells: a possible mechanism for repression of aromatase expression upon luteinizing hormone surge. Endocrinology 2005 146(1):237-46 PubMed ID: 15486232 DOI: 10.1210/en.2004-0889

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19902 Chen Q, Chen Q, Song Y, Xiang Y, Li Q, Sang Y, Zhang L, Bai L, Zhu Y. Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction Mol Cell Endocrinol 2024 580:112084 PubMed ID: 37923054 DOI: 10.1016/j.mce.2023.112084

17738 Qin L, Sitticharoon C, Petyim S, Keadkraichaiwat I, Sririwichitchai R, Maikaew P, Churintaraphan M. A Longitudinal Study of the Relationship of Adiponectin with Reproduction in Infertile Women Undergoing IVF/ICSI Treatment, and an Experimental Study in Human Granulosa Cells Life (Basel) 2023 13(4):994 PubMed ID: 37109523 DOI: 10.3390/life13040994

19900 Wu Q, Chen M, Li Y, Zhao X, Fan C, Dai Y. Paeoniflorin Alleviates Cisplatin-Induced Diminished Ovarian Reserve by Restoring the Function of Ovarian Granulosa Cells via Activating FSHR/cAMP/PKA/CREB Signaling Pathway Molecules 2023 28(24):8123 PubMed ID: 38138611 DOI: 10.3390/molecules28248123

19901 Vann K, Weidner AE, Walczyk AC, Astapova O. Paxillin knockout in mouse granulosa cells increases fecundity† Biol Reprod 2023 109(5):669-683 PubMed ID: 37552051 DOI: 10.1093/biolre/ioad093

19903 Pierson Smela MD, Kramme CC, Fortuna PRJ, Adams JL, Su R, Dong E, Kobayashi M, Brixi G, Kavirayuni VS, Tysinger E, Kohman RE, Shioda T, Chatterjee P, Church GM. Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression Elife 2023 12:e83291 PubMed ID: 36803359 DOI: 10.7554/eLife.83291

19905 Lee DH, Park H, You JH, Seok J, Kwon DW, Kim YR, Kim GJ. Increased IGFBP2 Levels by Placenta-Derived Mesenchymal Stem Cells Enhance Glucose Metabolism in a TAA-Injured Rat Model via AMPK Signaling Pathway Int J Mol Sci 2023 24(22):16531 PubMed ID: 38003735 DOI: 10.3390/ijms242216531

19907 Ji R, Jia F, Chen X, Gao Y, Yang J. Carnosol inhibits KGN cells oxidative stress and apoptosis and attenuates polycystic ovary syndrome phenotypes in mice through Keap1-mediated Nrf2/HO-1 activation Phytother Res 2023 1405-1421 PubMed ID: 36786429 DOI: 10.1002/ptr.7749

19908 Bao D, Gao L, Xin H, Wang L. lncRNA-FMR6 directly binds SAV1 to increase apoptosis of granulosa cells in premature ovarian failure J Ovarian Res 2023 16(1):65 PubMed ID: 37005611 DOI: 10.1186/s13048-023-01121-5

19909 Yan MQ, Zhu BH, Liu XH, Yang YM, Duan XY, Wang Y, Sun H, Feng M, Li T, Liu XM. Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway Cell Death Dis 2023 14(11):779 PubMed ID: 38012141 DOI: 10.1038/s41419-023-06312-y

19910 Wan S, Chen Q, Xiang Y, Sang Y, Tang M, Song Y, Feng G, Ye B, Bai L, Zhu Y. Interleukin-1 increases cyclooxygenase-2 expression and prostaglandin E2 production in human granulosa-lutein cell via nuclear factor kappa B/P65 and extracellular signal-regulated kinase 1/2 signaling pathways Mol Cell Endocrinol 2023 566-567:111891 PubMed ID: 36801432 DOI: 10.1016/j.mce.2023.111891

19912 Chen YC, Yeh YC, Lin YF, Au HK, Hsia SM, Chen YH, Hsieh RH. Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk Int J Mol Sci 2023 23(21):12740 PubMed ID: 36361530 DOI: 10.3390/ijms232112740

20992 Li T, Vazakidou P, Leonards PEG, Damdimopoulos A, Panagiotou EM, Arnelo C, Jansson K, Pettersson K, Papaikonomou K, van Duursen M, Damdimopoulou P. Identification of Biomarkers and Outcomes of Endocrine Disruption in Human Ovarian Cortex Using In Vitro Models. Toxicology 2023 PubMed ID: 36621641 DOI: 10.1016/j.tox.2023.153425

21017 Gogola-Mruk J, Tworzydło W, Krawczyk K, Marynowicz W, Ptak A. Visfatin induces ovarian cancer resistance to anoikis by regulating mitochondrial activity. Endocrine 2023 PubMed ID: 36658296 DOI: 10.1007/s12020-023-03305-x

21099 Gogola-Mruk J, Marynowicz W, Krawczyk K, Ptak A. Visfatin increases the invasive potential of ovarian granulosa tumor spheroids by reprogramming glucose metabolism. Reproduction 2023 PubMed ID: 36880885 DOI: 10.1530/REP-22-0443

21157 Yan MQ, Wang Y, Wang Z, Liu XH, Yang YM, Duan XY, Sun H, Liu XM. Mitoguardin2 Is Associated With Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells. J Endocr Soc 2023 7(5):bvad034 PubMed ID: 36936714 DOI: 10.1210/jendso/bvad034

21201 Tarvainen I, Soto DA, Laws MJ, Björvang RD, Damdimopoulos A, Roos K, Li T, Kramer S, Li Z, Lavogina D, Visser N, Kallak TK, Lager S, Gidlöf S, Edlund E, Papaikonomou K, Öberg M, Olovsson M, Salumets A, Velthut-Meikas A, Flaws JA, Damdimopoulou P. Identification of phthalate mixture exposure targets in the human and mouse ovary in vitro. Reprod Toxicol 2023 119:108393 PubMed ID: 37160244 DOI: 10.1016/j.reprotox.2023.108393

21321 Marynowicz W, Borski N, Flis Z, Ptak A, Molik E. Orotic acid induces apoptotic death in ovarian adult granulosa tumour cells and increases mitochondrial activity in normal ovarian granulosa cells. Reprod Biol 2023 23(3):100790 PubMed ID: 37478515 DOI: 10.1016/j.repbio.2023.100790

21341 Zhou Y, Yuan F, Jia C, Chen F, Li F, Wang L. MiR-497-3p induces Premature ovarian failure by targeting KLF4 to inactivate Klotho/PI3K/AKT/mTOR signaling pathway. Cytokine 2023 170:156294 PubMed ID: 37549487 DOI: 10.1016/j.cyto.2023.156294

21372 Chiang YF, Lin IC, Huang KC, Chen HY, Ali M, Huang YJ, Hsia SM. Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress. Biomed Pharmacother 2023 166:115327 PubMed ID: 37619480 DOI: 10.1016/j.biopha.2023.115327

21438 Liu D, Guan X, Liu W, Jia Y, Zhou H, Xi C, Zhao M, Fang Y, Wu L, Li K. Identification of transcriptome characteristics of granulosa cells and the possible role of UBE2C in the pathogenesis of premature ovarian insufficiency. J Ovarian Res 2023 16(1):203 PubMed ID: 37848988 DOI: 10.1186/s13048-023-01266-3

21475 Zhang L, Liu K, Liu Z, Tao H, Fu X, Hou J, Jia G, Hou Y. Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin Subheading. J Adv Res 2023 PubMed ID: 37956860 DOI: 10.1016/j.jare.2023.11.008

21573 Park JE, Lee SG, Lee SJ, Yu WJ, Kim JM. Downregulation of the Expression of Steroidogenic Acute Regulatory Protein and Aromatase in Steroidogenic KGN Human Granulosa Cells after Exposure to Bisphenol A. Dev Reprod 2023 27(4):185-193 PubMed ID: 38292236 DOI: 10.12717/DR.2023.27.4.185

17625 Shi CY, Xu JJ, Li C, Yu JL, Wu YT, Huang HF. A PPARG Splice Variant in Granulosa Cells Is Associated with Polycystic Ovary Syndrome J Clin Med 2022 11(24):7285 PubMed ID: 36555903 DOI: 10.3390/jcm11247285

17690 Olivia Cardinal, Chloé Burlot, Yangxin Fu, Powel Crosley, Mary Hitt, Morgan Craig, Adrianne L. Jenner Establishing combination PAC‐1 and TRAIL regimens for treating ovarian cancer based on patient‐specific pharmacokinetic profiles usingin silicoclinical trials Computational and Systems Oncology 2022 2 DOI: 10.1002/cso2.1035

19904 Kaseder M, Schmid N, Eubler K, Goetz K, Müller-Taubenberger A, Dissen GA, Harner M, Wanner G, Imhof A, Forne I, Mayerhofer A. Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells Mol Hum Reprod 2022 28(10):gaac030 PubMed ID: 35944223 DOI: 10.1093/molehr/gaac030

20340 Niu Q, Shi J, Gao Q, Fu J. WNT5A Enhances LH-Mediated Expression of HAS2 in Granulosa Cells. Reprod Sci 2022 PubMed ID: 34542891 DOI: 10.1007/s43032-021-00736-7

20535 Zhang L, Mao B, Zhao X, Yuan Y, Wang W, Lin S. Translation regulatory long non-coding RNA 1 (TRERNA1) sponges microRNA-23a to suppress granulosa cell apoptosis in premature ovarian failure. Bioengineered 2022 13(2):2173-2180 PubMed ID: 35034562 DOI: 10.1080/21655979.2021.2023802

20543 Mi X, Jiao W, Yang Y, Qin Y, Chen ZJ, Zhao S. HGF Secreted by Mesenchymal Stromal Cells Promotes Primordial Follicle Activation by Increasing the Activity of the PI3K-AKT Signaling Pathway. Stem Cell Rev Rep 2022 PubMed ID: 35089464 DOI: 10.1007/s12015-022-10335-x

16239 Cluzet V, Devillers MM, Petit F, Pierre A, Giton F, Airaud E, L'Hôte D, Leary A, Genestie C, Treilleux I, Mayeur A, Katzenellenbogen JA, Kim SH, Cohen-Tannoudji J, Chauvin S, Guigon CJ. Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα-dependent mechanism J Pathol 2022 256(3):335-348 PubMed ID: 34860414 DOI: 10.1002/path.5843

20528 Shao T, Ke H, Liu R, Xu L, Han S, Zhang X, Dang Y, Jiao X, Li W, Chen ZJ, Qin Y, Zhao S. Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1. Autophagy 2022 1-15 PubMed ID: 35025698 DOI: 10.1080/15548627.2021.2005415

20651 Asma A, Marc-André S. Melatonin Signaling Pathways Implicated in Metabolic Processes in Human Granulosa Cells (KGN). Int J Mol Sci 2022 23(6) PubMed ID: 35328408 DOI: 10.3390/ijms23062988

16505 Nishigaki A, Tsubokura H, Ishida M, Hashimoto Y, Yoshida A, Hisamatsu Y, Tsuzuki-Nakao T, Murata H, Okada H. NDRG1 is expressed in human granulosa cells: An implicative role of NDRG1 in the ovary Reprod Med Biol 2022 21(1):e12437 PubMed ID: 35386369 DOI: 10.1002/rmb2.12437

16767 Chen H, Chen Q, Zhu Y, Yuan K, Li H, Zhang B, Jia Z, Zhou H, Fan M, Qiu Y, Zhuang Q, Lei Z, Li M, Huang W, Liang L, Yan Q, Wang C. MAP3K1 Variant Causes Hyperactivation of Wnt4/β-Catenin/FOXL2 Signaling Contributing to 46,XY Disorders/Differences of Sex Development Front Genet 2022 13:736988 PubMed ID: 35309143 DOI: 10.3389/fgene.2022.736988

20777 Panagiotou EM, Draskau MK, Li T, Hirschberg AL, Svingen T, Damdimopoulou P. AOP Key Event Relationship Report: Linking decreased androgen receptor activation with decreased granulosa cell proliferation of gonadotropin-independent follicles. Reprod Toxicol 2022 PubMed ID: 35868514 DOI: 10.1016/j.reprotox.2022.07.004

20804 Choi Y, Luo Y, Lee S, Jin H, Yoon HJ, Hahn Y, Bae J, Lee HH. FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res 2022 50(15):8929-8946 PubMed ID: 35920317 DOI: 10.1093/nar/gkac673

17003 Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J. Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN Arch Biochem Biophys 2022 715:109094 PubMed ID: 34813774 DOI: 10.1016/j.abb.2021.109094

17013 Zhang QY, Li X, Zhou XY, Li Y, Zhang J, Zhang XF, Liu YD, Chen YX, Wu XM, Ma LZ, Chen X, Chen SL. Study of differential proteomics in granulosa cells of premature ovarian insufficiency (POI) and the roles and mechanism of RAC1 in granulosa cells Mol Cell Endocrinol 2022 555:111719 PubMed ID: 35850487 DOI: 10.1016/j.mce.2022.111719

17015 Kang W, Ishida E, Amita M, Tatsumi K, Yonezawa H, Yohtsu M, Katano D, Onozawa K, Kaneko E, Iwasaki W, Naito N, Yamada M, Kawano N, Miyado M, Sato B, Saito H, Saito T, Miyado K. Trehalose Suppresses Lysosomal Anomalies in Supporting Cells of Oocytes and Maintains Female Fertility Nutrients 2022 14(10):2156 PubMed ID: 35631296 DOI: 10.3390/nu14102156

20854 Wang W, Hao J, Shi Y. IL23 suppresses proliferation and promotes apoptosis of human granulosa-like tumor cell line KGN by targeting the androgen receptor signal pathway. Gynecol Endocrinol 2022 1-6 PubMed ID: 36123810 DOI: 10.1080/09513590.2022.2123914

20902 Arjoune A, Sirard MA. The genomic response of human granulosa cells (KGN) to melatonin and specific agonists/antagonists to the melatonin receptors. Sci Rep 2022 12(1):17539 PubMed ID: 36266374 DOI: 10.1038/s41598-022-21162-y

20984 Gogola-Mruk J, Krawczyk K, Marynowicz W, Rokita M, Nimpsz S, Ptak A. Bisphenols S and F drive ovarian granulosa cell tumor invasion via a metabolic switch. Toxicol Lett 2022 PubMed ID: 36584861 DOI: 10.1016/j.toxlet.2022.12.011

21027 Zheng Q, Liu M, Fu J. ALG2 inhibits the epithelial-to-mesenchymal transition and stemness of ovarian granulosa cells through the Wnt/β-catenin signaling pathway in polycystic ovary syndrome. Reprod Biol 2022 22(4):100706 PubMed ID: 36327672 DOI: 10.1016/j.repbio.2022.100706

17383 Chen H, Fu Y, Guo Z, Zhou X. MicroRNA-29c-3p participates in insulin function to modulate polycystic ovary syndrome via targeting Forkhead box O 3 Bioengineered 2022 13(2):4361-4371 PubMed ID: 35142592 DOI: 10.1080/21655979.2022.2033014

13389 Li D, Wang X, Dang Y, Zhang X, Zhao S, Lu G, Chan WY, Leung PCK, Qin Y. lncRNA GCAT1 is involved in premature ovarian insufficiency by regulating p27 translation in GCs via competitive binding to PTBP1. Mol Ther Nucleic Acids 2021 PubMed ID: 33335798 DOI: 10.1016/j.omtn.2020.10.041

20143 Li D, Wang X, Li G, Dang Y, Zhao S, Qin Y. LncRNA ZNF674-AS1 regulates granulosa cell glycolysis and proliferation by interacting with ALDOA. Cell Death Discov 2021 7(1):107 PubMed ID: 33993190 DOI: 10.1038/s41420-021-00493-1

20306 Jiao X, Zhang X, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ, Chen W, Qin Y. Treg deficiency-mediated TH 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells. Clin Transl Med 2021 11(6):e448 PubMed ID: 34185428 DOI: 10.1002/ctm2.448

15496 Kotomura N, Harada N, Shimono Y, Ishihara S. Transcriptional regulation of CYP1 9 by cohesin-mediated chromosome tethering in human granulosa cells Biochem Biophys Rep 2021 27:101086 PubMed ID: 34368471 DOI: 10.1016/j.bbrep.2021.101086

15497 Xu X, Song X, Xu X, Zheng Y, Xu L, Shen L. Inhibition of sestrin 1 alleviates polycystic ovary syndrome by decreasing autophagy Aging (Albany NY) 2021 13(8):11774-11785 PubMed ID: 33883304 DOI: 10.18632/aging.202872

15513 Li Y, Liu YD, Zhou XY, Zhang J, Wu XM, Yang YZ, Chen YX, Zhang XF, Li X, Ma LZ, Wang Z, Chen SL. Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism Mol Cell Endocrinol 2021 535:111392 PubMed ID: 34246727 DOI: 10.1016/j.mce.2021.111392

20383 Xu L, Xiong F, Bai Y, Xiao J, Zhang Y, Chen J, Li Q. Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome. Reprod Biol Endocrinol 2021 19(1):167 PubMed ID: 34740363 DOI: 10.1186/s12958-021-00839-5

20386 Zheng C, Liu S, Qin Z, Zhang X, Song Y. LncRNA DLEU1 is overexpressed in premature ovarian failure and sponges miR-146b-5p to increase granulosa cell apoptosis. J Ovarian Res 2021 14(1):151 PubMed ID: 34740384 DOI: 10.1186/s13048-021-00905-x

20395 Li D, Xu W, Wang X, Dang Y, Xu L, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y. lncRNA DDGC participates in premature ovarian insufficiency through regulating RAD51 and WT1. Mol Ther Nucleic Acids 2021 26:1092-1106 PubMed ID: 34786213 DOI: 10.1016/j.omtn.2021.10.015

20429 Zhou XY, Zhang J, Li Y, Chen YX, Wu XM, Li X, Zhang XF, Ma LZ, Yang YZ, Zheng KM, Liu YD, Wang Z, Chen SL. Advanced Oxidation Protein Products Induce G1/G0-Phase Arrest in Ovarian Granulosa Cells via the ROS-JNK/p38 MAPK-p21 Pathway in Premature Ovarian Insufficiency. Oxid Med Cell Longev 2021 2021:6634718 PubMed ID: 34367464 DOI: 10.1155/2021/6634718

15886 Wu YX, Lin YS, Li SC, Yao X, Cheng M, Zhu L, Liu HY. microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor Reprod Biol Endocrinol 2021 19(1):170 PubMed ID: 34814928 DOI: 10.1186/s12958-021-00850-w

20485 Tremblay PG, Fortin C, Sirard MA. Gene cascade analysis in human granulosa tumor cells (KGN) following exposure to high levels of free fatty acids and insulin. J Ovarian Res 2021 14(1):178 PubMed ID: 34930403 DOI: 10.1186/s13048-021-00934-6

20719 Schmid N, Dietrich KG, Forne I, Burges A, Szymanska M, Meidan R, Mayr D, Mayerhofer A. Sirtuin 1 and Sirtuin 3 in Granulosa Cell Tumors. Int J Mol Sci 2021 22(4) PubMed ID: 33669567 DOI: 10.3390/ijms22042047

16858 J Gogola-Mruk, K Krawczyk, W Marynowicz, A Ptak 210 Visfatin increases invasion in human adult granulosa tumor cell line by stimulation of glucose metabolism reprogramming Ovarian cancer 2021 DOI: 10.1136/ijgc-2021-esgo.357

16859 I Rodolakis, A Prodromidou, M Sotiropoulou, M Liontos, D Haidopoulos, A Bamias, D Loutradis, N Thomakos, A Rodolakis 217 The impact of chemotherapy response score and lymphocytic infiltration in patients with ovarian cancer treated with neoadjuvant chemotherapy Ovarian cancer 2021 DOI: 10.1136/ijgc-2021-esgo.358

16872 G Cass, R Lewes, J Pawade, C Newton 219 Skin capillary density as a novel biomarker of cytotoxic and bevacizumab treatment in ovarian cancer: a prospective clinical trial Ovarian cancer 2021 DOI: 10.1136/ijgc-2021-esgo.359

16891 Liu H, Jin H, Kim G, Bae J. A low dose of bisphenol A stimulates estradiol production by regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells Biochem Biophys Res Commun 2021 583:192-198 PubMed ID: 34749236 DOI: 10.1016/j.bbrc.2021.10.070

17006 Crosley P, Farkkila A, Jenner AL, Burlot C, Cardinal O, Potts KG, Agopsowicz K, Pihlajoki M, Heikinheimo M, Craig M, Fu Y, Hitt MM. Procaspase-Activating Compound-1 Synergizes with TRAIL to Induce Apoptosis in Established Granulosa Cell Tumor Cell Line (KGN) and Explanted Patient Granulosa Cell Tumor Cells In Vitro Int J Mol Sci 2021 22(9):4699 PubMed ID: 33946730 DOI: 10.3390/ijms22094699

17024 Qin L, Sitticharoon C, Petyim S, Keadkraichaiwat I, Sririwichitchai R, Maikeaw P, Churintaraphan M, Sripong C. Roles of kisspeptin in IVF/ICSI-treated infertile women and in human granulosa cells Exp Biol Med (Maywood) 2021 246(8):996-1010 PubMed ID: 33327782 DOI: 10.1177/1535370220981006

19906 Huang X, Wu B, Chen M, Hong L, Kong P, Wei Z, Teng X. Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome Aging (Albany NY) 2020 12(15):15414-15435 PubMed ID: 32651991 DOI: 10.18632/aging.103602

11980 Gogola J, Hoffmann M, Nimpsz S, Ptak A. Disruption of 17β-estradiol secretion by persistent organic pollutants present in human follicular fluid is dependent on the potential of ovarian granulosa tumor cell lines to metabolize estrogen. Mol. Cell. Endocrinol. 2020 PubMed ID: 31891770 DOI: 10.1016/j.mce.2019.110698

11988 Gogola J, Hoffmann M, Ptak A. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate IGF1 secretion by adult ovarian granulosa cell tumor spheroids and thereby increase proliferation of non-cancer ovarian granulosa cells. Toxicol In Vitro 2020 PubMed ID: 31923581 DOI: 10.1016/j.tiv.2020.104769

12055 Wu G, Yang Z, Chen Y, Li X, Yang J, Yin T. Downregulation of Lnc-OC1 attenuates the pathogenesis of polycystic ovary syndrome. Mol. Cell. Endocrinol. 2020 PubMed ID: 32070768 DOI: 10.1016/j.mce.2020.110760

12068 Wang X, Zhang X, Dang Y, Li D, Lu G, Chan WY, Leung PCK, Zhao S, Qin Y, Chen ZJ. Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1. Nucleic Acids Res. 2020 PubMed ID: 32112110 DOI: 10.1093/nar/gkaa127

12093 Nishigaki A, Kido T, Kida N, Kakita-Kobayashi M, Tsubokura H, Hisamatsu Y, Okada H. Resveratrol protects mitochondrial quantity by activating SIRT1/PGC-1α expression during ovarian hypoxia. Reprod. Med. Biol. 2020 PubMed ID: 32273826 DOI: 10.1002/rmb2.12323

12161 Xiangmin Lv, Chunbo He, Cong Huang , Guohua Hua, Xingcheng Chen, Barbara K.Timm, Victoria M.Maclin, Abigail A.Haggerty, Shelly K.Aust, Denae M.Golden, Bhavana J.Dave, Yun-An Tseng, Li Chen, Hongbo Wang, Peichao Chen, David L.Klinkebiel, Adam R.Karpf, Jixin Dong, Ronny I.Drapkin, Bo R.Rueda, John S.Davis, Cheng Wang Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features Science Bulletin 2020 65(15):1281-1296 PubMed ID: 34888112 DOI: 10.1016/j.scib.2020.03.040

12495 Silber M, Miller I, Bar-Joseph H, Ben-Ami I, Shalgi R. Elucidating the role of pigment epithelium-derived factor (PEDF) in metabolic PCOS models J Endocrinol 2020 244(2):297-308 PubMed ID: 31661672 DOI: 10.1530/JOE-19-0297

12995 Jin H, Lee B, Luo Y, Choi Y, Choi EH, Jin H, Kim KB, Seo SB, Kim YH, Lee HH, Kim KP, Lee K, Bae J. FOXL2 directs DNA double-strand break repair pathways by differentially interacting with Ku. Nat Commun 2020 PubMed ID: 32332759 DOI: 10.1038/s41467-020-15748-1

13030 Zhang X, Dang Y, Liu R, Zhao S, Ma J, Qin Y. MicroRNA-127-5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency. J Cell Physiol 2020 PubMed ID: 32391592 DOI: 10.1002/jcp.29725

13187 Lin YY, Sun D, Wu YL. Novel regulation of PKC-induced inflammation by Akt and protein phosphatase 2A in ovarian granulosa cells. Chin J Physiol 2020 PubMed ID: 32859885 DOI: 10.4103/CJP.CJP_44_20

13507 Lee SY, Kang YJ, Kwon J, Nishi Y, Yanase T, Lee KA, Koong MK. miR-4463 regulates aromatase expression and activity for 17β-estradiol synthesis in response to follicle-stimulating hormone Clin Exp Reprod Med 2020 47(3):194-206 PubMed ID: 32854459 DOI: 10.5653/cerm.2019.03412

14808 Shin E, Jin H, Suh DS, Luo Y, Ha HJ, Kim TH, Hahn Y, Hyun S, Lee K, Bae J. An alternative miRISC targets a cancer-associated coding sequence mutation in FOXL2 EMBO J 2020 39(24):e104719. PubMed ID: 33215742 DOI: 10.15252/embj.2020104719

16122 Man Y, Zhao R, Gao X, Liu Y, Zhao S, Lu G, Chan WY, Leung PCK, Bian Y. TOX3 Promotes Ovarian Estrogen Synthesis: An RNA-Sequencing and Network Study Front Endocrinol (Lausanne) 2020 11:615846 PubMed ID: 33716953 DOI: 10.3389/fendo.2020.615846

17005 Du J, Lin X, Wu R, Gao Z, Du Y, Liao Y, Quan S. miR-424 suppresses proliferation and promotes apoptosis of human ovarian granulosa cells by targeting Apelin and APJ expression Am J Transl Res 2020 12(7):3660-3673 PubMed ID: 32774725

17009 Tremblay PG, Sirard MA. Gene analysis of major signaling pathways regulated by gonadotropins in human ovarian granulosa tumor cells (KGN) Biol Reprod 2020 103(3):583-598 PubMed ID: 32427331 DOI: 10.1093/biolre/ioaa079

17023 Li Y, Zhang J, Liu YD, Zhou XY, Chen X, Zhe J, Zhang QY, Zhang XF, Chen YX, Wang Z, Chen SL. Long non-coding RNA TUG1 and its molecular mechanisms in polycystic ovary syndrome RNA Biol 2020 17(12):1798-1810 PubMed ID: 32559120 DOI: 10.1080/15476286.2020.1783850

17026 Miller I, Bar-Joseph H, Nemerovsky L, Ben-Ami I, Shalgi R. Pigment epithelium-derived factor (PEDF) negates hyperandrogenic PCOS features J Endocrinol 2020 245(2):291-300 PubMed ID: 32171180 DOI: 10.1530/JOE-19-0603

21580 Haltia UM, Pihlajoki M, Andersson N, Mäkinen L, Tapper J, Cervera A, Horlings HM, Turpeinen U, Anttonen M, Bützow R, Unkila-Kallio L, Carpén O, Wilson DB, Heikinheimo M, Färkkilä A. Functional Profiling of FSH and Estradiol in Ovarian Granulosa Cell Tumors. J Endocr Soc 2020 4(4):bvaa034 PubMed ID: 32309755 DOI: 10.1210/jendso/bvaa034

11293 Gogola J, Hoffmann M, Ptak A. Persistent endocrine-disrupting chemicals found in human follicular fluid stimulate the proliferation of granulosa tumor spheroids via GPR30 and IGF1R but not via the classic estrogen receptors. Chemosphere 2019 PubMed ID: 30414542 DOI: 10.1016/j.chemosphere.2018.11.018

11466 Buck T, Hack CT, Berg D, Berg U, Kunz L, Mayerhofer A. The NADPH oxidase 4 is a major source of hydrogen peroxide in human granulosa-lutein and granulosa tumor cells. Sci Rep 2019 PubMed ID: 30837663 DOI: 10.1038/s41598-019-40329-8

11481 Li Y, Xiang Y, Song Y, Wan L, Yu G, Tan L. Dysregulated miR-142, -33b, and -423 in granulosa cells target TGFBR1 and SMAD7: a possible role in polycystic ovary syndrome. Mol. Hum. Reprod. 2019 PubMed ID: 30865275 DOI: 10.1093/molehr/gaz014

11596 Lv X, He C, Huang C, Wang H, Hua G, Wang Z, Zhou J, Chen X, Ma B, Timm BK, Maclin V, Dong J, Rueda BR, Davis JS, Wang C. Timely expression and activation of YAP1 in granulosa cells is essential for ovarian follicle development. FASEB J. 2019 PubMed ID: 31199671 DOI: 10.1096/fj.201900179RR

11734 Lin PH, Chang CC, Wu KH, Shih CK, Chiang W, Chen HY, Shih YH, Wang KL, Hong YH, Shieh TM, Hsia SM. Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-like Symptoms. Biomolecules 2019 PubMed ID: 31370285 DOI: 10.3390/biom9080327

11752 Li Y, Liu YD, Zhou XY, Chen SL, Chen X, Zhe J, Zhang J, Zhang QY, Chen YX. MiR-29a regulates the proliferation, aromatase expression, and estradiol biosynthesis of human granulosa cells in polycystic ovary syndrome. Mol. Cell. Endocrinol. 2019 PubMed ID: 31421163 DOI: 10.1016/j.mce.2019.110540

11753 Bagnjuk K, Kast VJ, Tiefenbacher A, Kaseder M, Yanase T, Burges A, Kunz L, Mayr D, Mayerhofer A. Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors - implications from studies in KGN. J Ovarian Res 2019 PubMed ID: 31412918 DOI: 10.1186/s13048-019-0549-6

11754 He T, Sun Y, Zhang Y, Zhao S, Zheng Y, Hao G, Shi Y. MicroRNA-200b and microRNA-200c are up-regulated in PCOS granulosa cell and inhibit KGN cell proliferation via targeting PTEN. Reprod. Biol. Endocrinol. 2019 PubMed ID: 31421682 DOI: 10.1186/s12958-019-0505-8

11876 Hack CT, Buck T, Bagnjuk K, Eubler K, Kunz L, Mayr D, Mayerhofer A. A Role for H2O2 and TRPM2 in the Induction of Cell Death: Studies in KGN Cells. Antioxidants (Basel) 2019 PubMed ID: 31671815 DOI: 10.3390/antiox8110518

11961 Jung DH, Hwang JT, Pyun BJ, Yu SY, Ko BS. Assessment of the Aromatase Inhibitory Activity of Ma-Huang-Tang (MHT) and Its Active Compounds. Evid Based Complement Alternat Med 2019 PubMed ID: 31929813 DOI: 10.1155/2019/4809846

12493 Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q. Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome J Cell Physiol 2019 234(5):7435-7447 PubMed ID: 30580448 DOI: 10.1002/jcp.27501

12494 Huang X, She L, Luo X, Huang S, Wu J. MiR-222 promotes the progression of polycystic ovary syndrome by targeting p27 Kip1 Pathol Res Pract 2019 215(5):918-923. PubMed ID: 30718101 DOI: 10.1016/j.prp.2019.01.038

12496 Liu Y, Wang Y, Wang F, Pan J, Xu J, Li J, Zhou C, Ding G, Wu Y, Liu X, Sheng J, Huang H. Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants Sci China Life Sci 2019 62(2):257-267 PubMed ID: 30267260 DOI: 10.1007/s11427-018-9379-x

14276 Chen H, Crosley P, Azad AK, Gupta N, Gokul N, Xu Z, Weinfeld M, Postovit LM, Pangas SA, Hitt MM, Fu Y. RUNX3 Promotes the Tumorigenic Phenotype in KGN, a Human Granulosa Cell Tumor-Derived Cell Line Int J Mol Sci 2019 20(14):3471 PubMed ID: 31311113 DOI: 10.3390/ijms20143471

17004 J Gogola, M Hoffmann, S Nimpsz, A Ptak EP859 Endocrine-disrupting chemicals present in human follicular fluid disrupt granulosa cell tumors E2 secretion dependent on estrogen metabolism potential ePoster 2019 DOI: 10.1136/ijgc-2019-esgo.908

17007 KR Gissum, S Drageset, I Vistad, J Hoel, R Strand, L Bjørge EP858 What you should know about tumor reductive surgery in advanced ovarian cancer – clinical recommendations from a patient perspective ePoster 2019 DOI: 10.1136/ijgc-2019-esgo.907

17010 P Giamougiannis, R Grabowska, CLM Morais, A Anagnostopoulos, L Whitham, E Tingi, G Owens, P Hadjiyiannakis, NJ Wood, PL Martin-Hirsch, FL Martin EP857 Distinguishing benign vs. cancer states in ovary based on spectrochemical analysis of ascites: a budget omics approach ePoster 2019 DOI: 10.1136/ijgc-2019-esgo.906

17025 Xu L, Wang W, Zhang X, Ke H, Qin Y, You L, Li W, Lu G, Chan WY, Leung PCK, Zhao S, Chen ZJ. Palmitic acid causes insulin resistance in granulosa cells via activation of JNK J Mol Endocrinol 2019 62(4):197-206 PubMed ID: 30913535 DOI: 10.1530/JME-18-0214

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10810 Hoffmann M, Rak A, Ptak A. Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells. Toxicol. Lett. 2018 291:61-69 PubMed ID: 29653259 DOI: 10.1016/j.toxlet.2018.04.004

11053 Leila Bouazzi, Mariangela Franco, Alexander Maret and Anna Biason-Lauber CBX2 and the Ovary: Novel Insights into Regulatory Networks in Humans J Gynecol Reprod Med 2018 2:1-9 DOI: 10.33140/jgrm/02/01/00002

11114 Hillman RT, Celestino J, Terranova C, Beird HC, Gumbs C, Little L, Nguyen T, Thornton R, Tippen S, Zhang J, Lu KH, Gershenson DM, Rai K, Broaddus RR, Futreal PA. KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary. Nat Commun 2018 9(1):2496 PubMed ID: 29950560 DOI: 10.1038/s41467-018-04950-x

4273 Hao J, Tuck AR, Sjödin MOD, Lindberg J, Sand A, Niklasson B, Argyraki M, Hovatta O, Damdimopoulou P. Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model. Toxicol. Appl. Pharmacol. 2018 PubMed ID: 29146461 DOI: 10.1016/j.taap.2017.11.009

14554 Huang X, Pan J, Wu B, Teng X. Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS Reprod Biol Endocrinol 2018 16(1):73 PubMed ID: 30075721 DOI: 10.1186/s12958-018-0392-4

14558 Zheng Q, Zhou F, Cui X, Liu M, Li Y, Liu S, Tan J, Yan Q. Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level Cell Physiol Biochem 2018 46(6):2297-2310 PubMed ID: 29734187 DOI: 10.1159/000489619

17008 Kandaraki EA, Chatzigeorgiou A, Papageorgiou E, Piperi C, Adamopoulos C, Papavassiliou AG, Koutsilieris M, Diamanti-Kandarakis E. Advanced glycation end products interfere in luteinizing hormone and follicle stimulating hormone signaling in human granulosa KGN cells Exp Biol Med (Maywood) 2018 243(1):29-33 PubMed ID: 28914097 DOI: 10.1177/1535370217731288

17018 Ciucci A, Ferrandina G, Mascilini F, Filippetti F, Scambia G, Zannoni GF, Gallo D. Estrogen receptor β: Potential target for therapy in adult granulosa cell tumors? Gynecol Oncol 2018 150(1):158-165 PubMed ID: 29786517 DOI: 10.1016/j.ygyno.2018.05.013

9709 Hirano M, Wada-Hiraike O, Fu H, Akino N, Isono W, Sakurabashi A, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Nishi Y, Yanase T, Harada M, Oishi H, Yano T, Koga K, Oda K, Kawana K, Fujii T, Osuga Y. The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis. Reprod Sci 2017 24(1):133-141 PubMed ID: 27252187 DOI: 10.1177/1933719116651150

10083 Hoffmann M, Fiedor E, Ptak A. Bisphenol A and its derivatives tetrabromobisphenol A and tetrachlorobisphenol A induce apelin expression and secretion in ovarian cancer cells through a peroxisome proliferator-activated receptor gamma-dependent mechanism. Toxicol. Lett. 2017 269:15-22 PubMed ID: 28111160 DOI: 10.1016/j.toxlet.2017.01.006

10221 Colombe S, Houllier L, Fleurot E, Levallet G, Benhaïm A, Bonnamy PJ, Levallet J. Syndecan 1 represses cell growth and FSH responsiveness in human granulosa cells. Reproduction 2017 153:797-808 PubMed ID: 28348070 DOI: 10.1530/REP-17-0074

10394 Ma X, Hayes E, Biswas A, Seger C, Prizant H, Hammes SR, Sen A. Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity. Endocrinology 2017 158:2944-2954 PubMed ID: 28666321 DOI: 10.1210/en.2017-00145

10465 Hoffmann M, Gogola J, Kotula-Balak M, Ptak A. Stimulation of ovarian cell proliferation by tetrabromobisphenol A but not tetrachlorobisphenol A through G protein-coupled receptor 30. Toxicol In Vitro 2017 45:54-59 PubMed ID: 28811233 DOI: 10.1016/j.tiv.2017.08.009

14259 Jin H, Won M, Shin E, Kim HM, Lee K, Bae J. EGR2 is a gonadotropin-induced survival factor that controls the expression of IER3 in ovarian granulosa cells Biochem Biophys Res Commun 2017 482(4):877-882 PubMed ID: 27890615 DOI: 10.1016/j.bbrc.2016.11.127

14260 Haltia UM, Andersson N, Yadav B, Färkkilä A, Kulesskiy E, Kankainen M, Tang J, Bützow R, Riska A, Leminen A, Heikinheimo M, Kallioniemi O, Unkila-Kallio L, Wennerberg K, Aittokallio T, Anttonen M. Systematic drug sensitivity testing reveals synergistic growth inhibition by dasatinib or mTOR inhibitors with paclitaxel in ovarian granulosa cell tumor cells Gynecol Oncol 2017 144(3):621-630 PubMed ID: 28104295 DOI: 10.1016/j.ygyno.2016.12.016

14262 Mathew L, Gaikwad A, Gonzalez A, Nugent EK, Smith JA. Evaluation of Active Hexose Correlated Compound (AHCC) in Combination With Anticancer Hormones in Orthotopic Breast Cancer Models Integr Cancer Ther 2017 16(3):300-307 PubMed ID: 28438054 DOI: 10.1177/1534735417704948

14567 Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q. ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats Cell Death Dis 2017 8(10):e3145 PubMed ID: 29072679 DOI: 10.1038/cddis.2017.494

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14707 Simon V, Avet C, Grange-Messent V, Wargnier R, Denoyelle C, Pierre A, Dairou J, Dupret JM, Cohen-Tannoudji J. Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway Endocrinology 2017 158(10):3200-3211 PubMed ID: 28977593 DOI: 10.1210/en.2017-00374

7361 Diamanti-Kandarakis E, Chatzigeorgiou A, Papageorgiou E, Koundouras D, Koutsilieris M. Advanced glycation end-products and insulin signaling in granulosa cells. Exp. Biol. Med. (Maywood) 2016 241:1438-45 PubMed ID: 25956684 DOI: 10.1177/1535370215584937

9513 Ernst J, Grabiec U, Greither T, Fischer B, Dehghani F. The endocannabinoid system in the human granulosa cell line KGN. Mol. Cell. Endocrinol. 2016 423:67-76 PubMed ID: 26773729 DOI: 10.1016/j.mce.2016.01.006

9719 Dou YD, Zhao H, Huang T, Zhao SG, Liu XM, Yu XC, Ma ZX, Zhang YC, Liu T, Gao X, Li L, Lu G, Chan WY, Gao F, Liu HB, Chen ZJ. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells. Sci Rep 2016 6:26691 PubMed ID: 27270953 DOI: 10.1038/srep26691

9805 Chao YN, Sun D, Peng YC, Wu YL. Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammation in Human Ovarian Granulosa Cells. Int J Mol Sci 2016 17: PubMed ID: 27548147 DOI: 10.3390/ijms17081359

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